-- dump date 20140619_122719 -- class Genbank::misc_feature -- table misc_feature_note -- id note 321967000001 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 321967000002 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 321967000003 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967000004 motif II; other site 321967000005 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 321967000006 Penicillinase repressor; Region: Pencillinase_R; pfam03965 321967000007 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 321967000008 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 321967000009 6-phospho-beta-galactosidase; Region: lacG; TIGR01233 321967000010 beta-galactosidase; Region: BGL; TIGR03356 321967000011 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 321967000012 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 321967000013 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 321967000014 active site 321967000015 P-loop; other site 321967000016 phosphorylation site [posttranslational modification] 321967000017 CAT RNA binding domain; Region: CAT_RBD; pfam03123 321967000018 transcriptional antiterminator BglG; Provisional; Region: PRK09772 321967000019 PRD domain; Region: PRD; pfam00874 321967000020 PRD domain; Region: PRD; pfam00874 321967000021 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 321967000022 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 321967000023 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 321967000024 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 321967000025 Integrase core domain; Region: rve; pfam00665 321967000026 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 321967000027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967000028 dimer interface [polypeptide binding]; other site 321967000029 conserved gate region; other site 321967000030 putative PBP binding loops; other site 321967000031 ABC-ATPase subunit interface; other site 321967000032 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 321967000033 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 321967000034 Walker A/P-loop; other site 321967000035 ATP binding site [chemical binding]; other site 321967000036 Q-loop/lid; other site 321967000037 ABC transporter signature motif; other site 321967000038 Walker B; other site 321967000039 D-loop; other site 321967000040 H-loop/switch region; other site 321967000041 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 321967000042 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 321967000043 substrate binding pocket [chemical binding]; other site 321967000044 membrane-bound complex binding site; other site 321967000045 hinge residues; other site 321967000046 MobA/MobL family; Region: MobA_MobL; pfam03389 321967000047 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 321967000048 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 321967000049 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 321967000050 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 321967000051 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 321967000052 P-loop; other site 321967000053 Magnesium ion binding site [ion binding]; other site 321967000054 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 321967000055 Magnesium ion binding site [ion binding]; other site 321967000056 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 321967000057 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 321967000058 multiple promoter invertase; Provisional; Region: mpi; PRK13413 321967000059 catalytic residues [active] 321967000060 catalytic nucleophile [active] 321967000061 Presynaptic Site I dimer interface [polypeptide binding]; other site 321967000062 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 321967000063 Synaptic Flat tetramer interface [polypeptide binding]; other site 321967000064 Synaptic Site I dimer interface [polypeptide binding]; other site 321967000065 DNA binding site [nucleotide binding] 321967000066 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 321967000067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 321967000068 Walker A motif; other site 321967000069 ATP binding site [chemical binding]; other site 321967000070 Walker B motif; other site 321967000071 arginine finger; other site 321967000072 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 321967000073 DnaA box-binding interface [nucleotide binding]; other site 321967000074 DNA polymerase III subunit beta; Validated; Region: PRK05643 321967000075 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 321967000076 putative DNA binding surface [nucleotide binding]; other site 321967000077 dimer interface [polypeptide binding]; other site 321967000078 beta-clamp/clamp loader binding surface; other site 321967000079 beta-clamp/translesion DNA polymerase binding surface; other site 321967000080 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 321967000081 recombination protein F; Reviewed; Region: recF; PRK00064 321967000082 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 321967000083 Walker A/P-loop; other site 321967000084 ATP binding site [chemical binding]; other site 321967000085 Q-loop/lid; other site 321967000086 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967000087 ABC transporter signature motif; other site 321967000088 Walker B; other site 321967000089 D-loop; other site 321967000090 H-loop/switch region; other site 321967000091 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 321967000092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 321967000093 Mg2+ binding site [ion binding]; other site 321967000094 G-X-G motif; other site 321967000095 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 321967000096 anchoring element; other site 321967000097 dimer interface [polypeptide binding]; other site 321967000098 ATP binding site [chemical binding]; other site 321967000099 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 321967000100 active site 321967000101 metal binding site [ion binding]; metal-binding site 321967000102 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 321967000103 DNA gyrase subunit A; Validated; Region: PRK05560 321967000104 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 321967000105 CAP-like domain; other site 321967000106 active site 321967000107 primary dimer interface [polypeptide binding]; other site 321967000108 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 321967000109 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 321967000110 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 321967000111 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 321967000112 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 321967000113 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 321967000114 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 321967000115 intersubunit interface [polypeptide binding]; other site 321967000116 active site 321967000117 catalytic residue [active] 321967000118 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 321967000119 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 321967000120 dimer interface [polypeptide binding]; other site 321967000121 ssDNA binding site [nucleotide binding]; other site 321967000122 tetramer (dimer of dimers) interface [polypeptide binding]; other site 321967000123 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 321967000124 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 321967000125 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 321967000126 dimer interface [polypeptide binding]; other site 321967000127 ssDNA binding site [nucleotide binding]; other site 321967000128 tetramer (dimer of dimers) interface [polypeptide binding]; other site 321967000129 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 321967000130 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 321967000131 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 321967000132 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 321967000133 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 321967000134 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 321967000135 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967000136 Integrase core domain; Region: rve; pfam00665 321967000137 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 321967000138 CHAP domain; Region: CHAP; pfam05257 321967000139 Surface antigen [General function prediction only]; Region: COG3942 321967000140 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 321967000141 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 321967000142 FtsX-like permease family; Region: FtsX; pfam02687 321967000143 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 321967000144 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 321967000145 Walker A/P-loop; other site 321967000146 ATP binding site [chemical binding]; other site 321967000147 Q-loop/lid; other site 321967000148 ABC transporter signature motif; other site 321967000149 Walker B; other site 321967000150 D-loop; other site 321967000151 H-loop/switch region; other site 321967000152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 321967000153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 321967000154 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967000155 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 321967000156 active site 321967000157 motif I; other site 321967000158 motif II; other site 321967000159 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 321967000160 hypothetical protein; Provisional; Region: PRK10621 321967000161 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 321967000162 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 321967000163 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 321967000164 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 321967000165 Cl binding site [ion binding]; other site 321967000166 oligomer interface [polypeptide binding]; other site 321967000167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 321967000168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 321967000169 manganese transport protein MntH; Reviewed; Region: PRK00701 321967000170 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 321967000171 Peptidase family C69; Region: Peptidase_C69; pfam03577 321967000172 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967000173 Integrase core domain; Region: rve; pfam00665 321967000174 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 321967000175 active site 321967000176 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 321967000177 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967000178 Integrase core domain; Region: rve; pfam00665 321967000179 Predicted membrane protein [Function unknown]; Region: COG4392 321967000180 CAAX protease self-immunity; Region: Abi; pfam02517 321967000181 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967000182 Integrase core domain; Region: rve; pfam00665 321967000183 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 321967000184 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 321967000185 active site 321967000186 intersubunit interface [polypeptide binding]; other site 321967000187 catalytic residue [active] 321967000188 Transcriptional regulators [Transcription]; Region: GntR; COG1802 321967000189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 321967000190 DNA-binding site [nucleotide binding]; DNA binding site 321967000191 FCD domain; Region: FCD; pfam07729 321967000192 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 321967000193 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 321967000194 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 321967000195 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 321967000196 Walker A/P-loop; other site 321967000197 ATP binding site [chemical binding]; other site 321967000198 Q-loop/lid; other site 321967000199 ABC transporter signature motif; other site 321967000200 Walker B; other site 321967000201 D-loop; other site 321967000202 H-loop/switch region; other site 321967000203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967000204 Major Facilitator Superfamily; Region: MFS_1; pfam07690 321967000205 putative substrate translocation pore; other site 321967000206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967000207 Predicted membrane protein [General function prediction only]; Region: COG4194 321967000208 MMPL family; Region: MMPL; pfam03176 321967000209 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 321967000210 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 321967000211 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 321967000212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967000213 putative PBP binding loops; other site 321967000214 dimer interface [polypeptide binding]; other site 321967000215 ABC-ATPase subunit interface; other site 321967000216 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 321967000217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967000218 dimer interface [polypeptide binding]; other site 321967000219 conserved gate region; other site 321967000220 putative PBP binding loops; other site 321967000221 ABC-ATPase subunit interface; other site 321967000222 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 321967000223 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 321967000224 Walker A/P-loop; other site 321967000225 ATP binding site [chemical binding]; other site 321967000226 Q-loop/lid; other site 321967000227 ABC transporter signature motif; other site 321967000228 Walker B; other site 321967000229 D-loop; other site 321967000230 H-loop/switch region; other site 321967000231 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 321967000232 CAAX protease self-immunity; Region: Abi; pfam02517 321967000233 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 321967000234 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 321967000235 Soluble P-type ATPase [General function prediction only]; Region: COG4087 321967000236 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 321967000237 metal-binding site [ion binding] 321967000238 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 321967000239 dinuclear metal binding motif [ion binding]; other site 321967000240 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 321967000241 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 321967000242 ligand binding site [chemical binding]; other site 321967000243 flexible hinge region; other site 321967000244 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 321967000245 putative switch regulator; other site 321967000246 non-specific DNA interactions [nucleotide binding]; other site 321967000247 DNA binding site [nucleotide binding] 321967000248 sequence specific DNA binding site [nucleotide binding]; other site 321967000249 putative cAMP binding site [chemical binding]; other site 321967000250 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 321967000251 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 321967000252 substrate binding site [chemical binding]; other site 321967000253 active site 321967000254 catalytic residues [active] 321967000255 heterodimer interface [polypeptide binding]; other site 321967000256 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 321967000257 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 321967000258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 321967000259 catalytic residue [active] 321967000260 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 321967000261 active site 321967000262 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 321967000263 active site 321967000264 ribulose/triose binding site [chemical binding]; other site 321967000265 phosphate binding site [ion binding]; other site 321967000266 substrate (anthranilate) binding pocket [chemical binding]; other site 321967000267 product (indole) binding pocket [chemical binding]; other site 321967000268 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 321967000269 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 321967000270 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 321967000271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967000272 Major Facilitator Superfamily; Region: MFS_1; pfam07690 321967000273 putative substrate translocation pore; other site 321967000274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967000275 putative substrate translocation pore; other site 321967000276 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 321967000277 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 321967000278 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 321967000279 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967000280 Walker A/P-loop; other site 321967000281 ATP binding site [chemical binding]; other site 321967000282 Q-loop/lid; other site 321967000283 ABC transporter signature motif; other site 321967000284 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967000285 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967000286 Integrase core domain; Region: rve; pfam00665 321967000287 dihydrodipicolinate reductase; Provisional; Region: PRK00048 321967000288 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 321967000289 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 321967000290 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 321967000291 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 321967000292 dimer interface [polypeptide binding]; other site 321967000293 active site 321967000294 catalytic residue [active] 321967000295 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 321967000296 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 321967000297 metal binding site [ion binding]; metal-binding site 321967000298 putative dimer interface [polypeptide binding]; other site 321967000299 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 321967000300 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 321967000301 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 321967000302 putative trimer interface [polypeptide binding]; other site 321967000303 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 321967000304 putative CoA binding site [chemical binding]; other site 321967000305 putative trimer interface [polypeptide binding]; other site 321967000306 putative CoA binding site [chemical binding]; other site 321967000307 diaminopimelate decarboxylase; Region: lysA; TIGR01048 321967000308 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 321967000309 active site 321967000310 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 321967000311 substrate binding site [chemical binding]; other site 321967000312 catalytic residues [active] 321967000313 dimer interface [polypeptide binding]; other site 321967000314 aspartate kinase; Reviewed; Region: PRK09034 321967000315 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 321967000316 putative catalytic residues [active] 321967000317 putative nucleotide binding site [chemical binding]; other site 321967000318 putative aspartate binding site [chemical binding]; other site 321967000319 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 321967000320 allosteric regulatory residue; other site 321967000321 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 321967000322 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 321967000323 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 321967000324 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 321967000325 Mediator complex subunit 23; Region: Med23; pfam11573 321967000326 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 321967000327 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 321967000328 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 321967000329 nudix motif; other site 321967000330 EamA-like transporter family; Region: EamA; pfam00892 321967000331 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 321967000332 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 321967000333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967000334 Walker A/P-loop; other site 321967000335 ATP binding site [chemical binding]; other site 321967000336 Q-loop/lid; other site 321967000337 ABC transporter signature motif; other site 321967000338 Walker B; other site 321967000339 D-loop; other site 321967000340 H-loop/switch region; other site 321967000341 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 321967000342 catalytic residues [active] 321967000343 glycoprotein BALF4; Provisional; Region: PHA03231 321967000344 Transposase domain (DUF772); Region: DUF772; pfam05598 321967000345 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 321967000346 tetracycline repressor protein TetR; Provisional; Region: PRK13756 321967000347 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 321967000348 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 321967000349 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 321967000350 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 321967000351 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 321967000352 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 321967000353 Walker A/P-loop; other site 321967000354 ATP binding site [chemical binding]; other site 321967000355 Q-loop/lid; other site 321967000356 ABC transporter signature motif; other site 321967000357 Walker B; other site 321967000358 D-loop; other site 321967000359 H-loop/switch region; other site 321967000360 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 321967000361 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 321967000362 DHH family; Region: DHH; pfam01368 321967000363 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 321967000364 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 321967000365 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 321967000366 replicative DNA helicase; Provisional; Region: PRK05748 321967000367 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 321967000368 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 321967000369 Walker A motif; other site 321967000370 ATP binding site [chemical binding]; other site 321967000371 Walker B motif; other site 321967000372 DNA binding loops [nucleotide binding] 321967000373 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 321967000374 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 321967000375 active site turn [active] 321967000376 phosphorylation site [posttranslational modification] 321967000377 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 321967000378 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 321967000379 HPr interaction site; other site 321967000380 glycerol kinase (GK) interaction site [polypeptide binding]; other site 321967000381 active site 321967000382 phosphorylation site [posttranslational modification] 321967000383 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 321967000384 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 321967000385 putative active site [active] 321967000386 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 321967000387 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 321967000388 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 321967000389 putative active site [active] 321967000390 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 321967000391 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 321967000392 GDP-binding site [chemical binding]; other site 321967000393 ACT binding site; other site 321967000394 IMP binding site; other site 321967000395 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 321967000396 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 321967000397 Soluble P-type ATPase [General function prediction only]; Region: COG4087 321967000398 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 321967000399 dimerization interface [polypeptide binding]; other site 321967000400 putative DNA binding site [nucleotide binding]; other site 321967000401 putative Zn2+ binding site [ion binding]; other site 321967000402 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 321967000403 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 321967000404 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 321967000405 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 321967000406 Transcriptional regulator [Transcription]; Region: LysR; COG0583 321967000407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 321967000408 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 321967000409 dimerization interface [polypeptide binding]; other site 321967000410 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 321967000411 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967000412 non-specific DNA binding site [nucleotide binding]; other site 321967000413 salt bridge; other site 321967000414 sequence-specific DNA binding site [nucleotide binding]; other site 321967000415 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 321967000416 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 321967000417 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 321967000418 Walker A/P-loop; other site 321967000419 ATP binding site [chemical binding]; other site 321967000420 Q-loop/lid; other site 321967000421 ABC transporter signature motif; other site 321967000422 Walker B; other site 321967000423 D-loop; other site 321967000424 H-loop/switch region; other site 321967000425 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 321967000426 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 321967000427 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 321967000428 ATP cone domain; Region: ATP-cone; pfam03477 321967000429 Class III ribonucleotide reductase; Region: RNR_III; cd01675 321967000430 effector binding site; other site 321967000431 active site 321967000432 Zn binding site [ion binding]; other site 321967000433 glycine loop; other site 321967000434 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 321967000435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967000436 non-specific DNA binding site [nucleotide binding]; other site 321967000437 salt bridge; other site 321967000438 sequence-specific DNA binding site [nucleotide binding]; other site 321967000439 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967000440 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967000441 Integrase core domain; Region: rve; pfam00665 321967000442 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 321967000443 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 321967000444 active site 321967000445 metal binding site [ion binding]; metal-binding site 321967000446 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 321967000447 FAD binding domain; Region: FAD_binding_4; pfam01565 321967000448 Transposase domain (DUF772); Region: DUF772; pfam05598 321967000449 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 321967000450 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 321967000451 active site 321967000452 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 321967000453 putative dimer interface [polypeptide binding]; other site 321967000454 catalytic triad [active] 321967000455 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 321967000456 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 321967000457 ATP-grasp domain; Region: ATP-grasp_4; cl17255 321967000458 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 321967000459 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 321967000460 DNA binding site [nucleotide binding] 321967000461 active site 321967000462 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 321967000463 D-lactate dehydrogenase; Validated; Region: PRK08605 321967000464 homodimer interface [polypeptide binding]; other site 321967000465 ligand binding site [chemical binding]; other site 321967000466 NAD binding site [chemical binding]; other site 321967000467 catalytic site [active] 321967000468 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 321967000469 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 321967000470 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 321967000471 NAD(P) binding site [chemical binding]; other site 321967000472 NAD(P) binding site [chemical binding]; other site 321967000473 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 321967000474 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 321967000475 Protein of unknown function (DUF1516); Region: DUF1516; pfam07457 321967000476 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 321967000477 DsrE/DsrF-like family; Region: DrsE; cl00672 321967000478 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 321967000479 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 321967000480 Zn binding site [ion binding]; other site 321967000481 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 321967000482 Zn binding site [ion binding]; other site 321967000483 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 321967000484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 321967000485 WxL domain surface cell wall-binding; Region: WxL; pfam13731 321967000486 WxL domain surface cell wall-binding; Region: WxL; pfam13731 321967000487 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 321967000488 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 321967000489 Mga helix-turn-helix domain; Region: Mga; pfam05043 321967000490 Protein of unknown function (DUF805); Region: DUF805; pfam05656 321967000491 Protein of unknown function (DUF805); Region: DUF805; pfam05656 321967000492 recombination factor protein RarA; Reviewed; Region: PRK13342 321967000493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 321967000494 Walker A motif; other site 321967000495 ATP binding site [chemical binding]; other site 321967000496 Walker B motif; other site 321967000497 arginine finger; other site 321967000498 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 321967000499 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 321967000500 propionate/acetate kinase; Provisional; Region: PRK12379 321967000501 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 321967000502 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 321967000503 active site 321967000504 metal binding site [ion binding]; metal-binding site 321967000505 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 321967000506 endonuclease III; Region: ENDO3c; smart00478 321967000507 minor groove reading motif; other site 321967000508 helix-hairpin-helix signature motif; other site 321967000509 substrate binding pocket [chemical binding]; other site 321967000510 active site 321967000511 Domain of unknown function DUF77; Region: DUF77; pfam01910 321967000512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 321967000513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 321967000514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967000515 Major Facilitator Superfamily; Region: MFS_1; pfam07690 321967000516 putative substrate translocation pore; other site 321967000517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967000518 putative phosphoketolase; Provisional; Region: PRK05261 321967000519 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 321967000520 TPP-binding site; other site 321967000521 XFP C-terminal domain; Region: XFP_C; pfam09363 321967000522 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 321967000523 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 321967000524 peptide binding site [polypeptide binding]; other site 321967000525 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 321967000526 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 321967000527 Walker A/P-loop; other site 321967000528 ATP binding site [chemical binding]; other site 321967000529 Q-loop/lid; other site 321967000530 ABC transporter signature motif; other site 321967000531 Walker B; other site 321967000532 D-loop; other site 321967000533 H-loop/switch region; other site 321967000534 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 321967000535 nudix motif; other site 321967000536 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 321967000537 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 321967000538 Walker A/P-loop; other site 321967000539 ATP binding site [chemical binding]; other site 321967000540 Q-loop/lid; other site 321967000541 ABC transporter signature motif; other site 321967000542 Walker B; other site 321967000543 D-loop; other site 321967000544 H-loop/switch region; other site 321967000545 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 321967000546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967000547 non-specific DNA binding site [nucleotide binding]; other site 321967000548 salt bridge; other site 321967000549 sequence-specific DNA binding site [nucleotide binding]; other site 321967000550 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 321967000551 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 321967000552 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 321967000553 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 321967000554 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 321967000555 Repair protein; Region: Repair_PSII; pfam04536 321967000556 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 321967000557 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 321967000558 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 321967000559 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 321967000560 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 321967000561 putative ligand binding site [chemical binding]; other site 321967000562 putative NAD binding site [chemical binding]; other site 321967000563 catalytic site [active] 321967000564 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 321967000565 Predicted membrane protein [Function unknown]; Region: COG2261 321967000566 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 321967000567 Asp23 family; Region: Asp23; pfam03780 321967000568 Asp23 family; Region: Asp23; pfam03780 321967000569 Protein of unknown function (DUF969); Region: DUF969; pfam06149 321967000570 Predicted membrane protein [Function unknown]; Region: COG3817 321967000571 Protein of unknown function (DUF979); Region: DUF979; pfam06166 321967000572 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 321967000573 putative substrate binding pocket [chemical binding]; other site 321967000574 AC domain interface; other site 321967000575 catalytic triad [active] 321967000576 AB domain interface; other site 321967000577 interchain disulfide; other site 321967000578 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 321967000579 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 321967000580 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 321967000581 catalytic triad [active] 321967000582 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 321967000583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967000584 S-adenosylmethionine binding site [chemical binding]; other site 321967000585 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 321967000586 ParB-like nuclease domain; Region: ParBc; pfam02195 321967000587 KorB domain; Region: KorB; pfam08535 321967000588 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 321967000589 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 321967000590 P-loop; other site 321967000591 Magnesium ion binding site [ion binding]; other site 321967000592 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 321967000593 Magnesium ion binding site [ion binding]; other site 321967000594 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 321967000595 ParB-like nuclease domain; Region: ParB; smart00470 321967000596 KorB domain; Region: KorB; pfam08535 321967000597 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 321967000598 GTP-binding protein YchF; Reviewed; Region: PRK09601 321967000599 YchF GTPase; Region: YchF; cd01900 321967000600 G1 box; other site 321967000601 GTP/Mg2+ binding site [chemical binding]; other site 321967000602 Switch I region; other site 321967000603 G2 box; other site 321967000604 Switch II region; other site 321967000605 G3 box; other site 321967000606 G4 box; other site 321967000607 G5 box; other site 321967000608 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 321967000609 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 321967000610 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 321967000611 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 321967000612 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 321967000613 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 321967000614 active site 321967000615 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 321967000616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 321967000617 active site 321967000618 phosphorylation site [posttranslational modification] 321967000619 intermolecular recognition site; other site 321967000620 dimerization interface [polypeptide binding]; other site 321967000621 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 321967000622 DNA binding site [nucleotide binding] 321967000623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 321967000624 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 321967000625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 321967000626 dimer interface [polypeptide binding]; other site 321967000627 phosphorylation site [posttranslational modification] 321967000628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 321967000629 ATP binding site [chemical binding]; other site 321967000630 Mg2+ binding site [ion binding]; other site 321967000631 G-X-G motif; other site 321967000632 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 321967000633 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 321967000634 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 321967000635 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 321967000636 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 321967000637 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 321967000638 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 321967000639 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 321967000640 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 321967000641 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 321967000642 aspartate racemase; Region: asp_race; TIGR00035 321967000643 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 321967000644 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 321967000645 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 321967000646 active site 321967000647 catalytic tetrad [active] 321967000648 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 321967000649 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 321967000650 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 321967000651 putative active site [active] 321967000652 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 321967000653 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 321967000654 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 321967000655 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 321967000656 N- and C-terminal domain interface [polypeptide binding]; other site 321967000657 active site 321967000658 catalytic site [active] 321967000659 metal binding site [ion binding]; metal-binding site 321967000660 carbohydrate binding site [chemical binding]; other site 321967000661 ATP binding site [chemical binding]; other site 321967000662 fructuronate transporter; Provisional; Region: PRK10034; cl15264 321967000663 Citrate transporter; Region: CitMHS; pfam03600 321967000664 Transposase domain (DUF772); Region: DUF772; pfam05598 321967000665 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 321967000666 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 321967000667 active site 321967000668 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 321967000669 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 321967000670 Probable Catalytic site; other site 321967000671 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 321967000672 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 321967000673 active site 321967000674 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 321967000675 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 321967000676 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 321967000677 active site 321967000678 SH3-like domain; Region: SH3_8; pfam13457 321967000679 SH3-like domain; Region: SH3_8; pfam13457 321967000680 SH3-like domain; Region: SH3_8; pfam13457 321967000681 SH3-like domain; Region: SH3_8; pfam13457 321967000682 SH3-like domain; Region: SH3_8; pfam13457 321967000683 SH3-like domain; Region: SH3_8; pfam13457 321967000684 SH3-like domain; Region: SH3_8; pfam13457 321967000685 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 321967000686 Homeodomain-like domain; Region: HTH_23; pfam13384 321967000687 Transposase; Region: DDE_Tnp_ISL3; pfam01610 321967000688 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 321967000689 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 321967000690 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 321967000691 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 321967000692 active site 321967000693 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 321967000694 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 321967000695 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 321967000696 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 321967000697 putative PBP binding regions; other site 321967000698 ABC-ATPase subunit interface; other site 321967000699 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 321967000700 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 321967000701 active site 321967000702 metal binding site [ion binding]; metal-binding site 321967000703 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 321967000704 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 321967000705 oligoendopeptidase F; Region: pepF; TIGR00181 321967000706 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 321967000707 active site 321967000708 Zn binding site [ion binding]; other site 321967000709 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 321967000710 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 321967000711 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 321967000712 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 321967000713 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 321967000714 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 321967000715 active site 321967000716 Protein of unknown function (DUF975); Region: DUF975; cl10504 321967000717 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 321967000718 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 321967000719 Catalytic site [active] 321967000720 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 321967000721 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 321967000722 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 321967000723 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 321967000724 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 321967000725 ABC transporter; Region: ABC_tran_2; pfam12848 321967000726 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 321967000727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967000728 S-adenosylmethionine binding site [chemical binding]; other site 321967000729 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 321967000730 catalytic residues [active] 321967000731 Uncharacterized conserved protein [Function unknown]; Region: COG2966 321967000732 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 321967000733 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 321967000734 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 321967000735 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 321967000736 putative ligand binding site [chemical binding]; other site 321967000737 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 321967000738 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 321967000739 TM-ABC transporter signature motif; other site 321967000740 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 321967000741 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 321967000742 TM-ABC transporter signature motif; other site 321967000743 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 321967000744 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 321967000745 Walker A/P-loop; other site 321967000746 ATP binding site [chemical binding]; other site 321967000747 Q-loop/lid; other site 321967000748 ABC transporter signature motif; other site 321967000749 Walker B; other site 321967000750 D-loop; other site 321967000751 H-loop/switch region; other site 321967000752 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 321967000753 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 321967000754 Walker A/P-loop; other site 321967000755 ATP binding site [chemical binding]; other site 321967000756 Q-loop/lid; other site 321967000757 ABC transporter signature motif; other site 321967000758 Walker B; other site 321967000759 D-loop; other site 321967000760 H-loop/switch region; other site 321967000761 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 321967000762 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 321967000763 conserved cys residue [active] 321967000764 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 321967000765 nudix motif; other site 321967000766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 321967000767 Transposase; Region: HTH_Tnp_1; pfam01527 321967000768 putative transposase OrfB; Reviewed; Region: PHA02517 321967000769 HTH-like domain; Region: HTH_21; pfam13276 321967000770 Integrase core domain; Region: rve; pfam00665 321967000771 Integrase core domain; Region: rve_3; pfam13683 321967000772 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 321967000773 metal binding site [ion binding]; metal-binding site 321967000774 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 321967000775 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 321967000776 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 321967000777 Class I aldolases; Region: Aldolase_Class_I; cl17187 321967000778 catalytic residue [active] 321967000779 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 321967000780 intersubunit interface [polypeptide binding]; other site 321967000781 active site 321967000782 catalytic residue [active] 321967000783 phosphopentomutase; Provisional; Region: PRK05362 321967000784 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 321967000785 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 321967000786 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 321967000787 NlpC/P60 family; Region: NLPC_P60; pfam00877 321967000788 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 321967000789 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 321967000790 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 321967000791 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 321967000792 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 321967000793 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 321967000794 DEAD/DEAH box helicase; Region: DEAD; pfam00270 321967000795 DEAD_2; Region: DEAD_2; pfam06733 321967000796 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 321967000797 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 321967000798 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 321967000799 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 321967000800 active site 321967000801 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 321967000802 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 321967000803 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967000804 Integrase core domain; Region: rve; pfam00665 321967000805 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 321967000806 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 321967000807 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 321967000808 Walker A/P-loop; other site 321967000809 ATP binding site [chemical binding]; other site 321967000810 Q-loop/lid; other site 321967000811 ABC transporter signature motif; other site 321967000812 Walker B; other site 321967000813 D-loop; other site 321967000814 H-loop/switch region; other site 321967000815 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 321967000816 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967000817 Walker A/P-loop; other site 321967000818 ATP binding site [chemical binding]; other site 321967000819 Q-loop/lid; other site 321967000820 ABC transporter signature motif; other site 321967000821 Walker B; other site 321967000822 D-loop; other site 321967000823 H-loop/switch region; other site 321967000824 Putative transcription activator [Transcription]; Region: TenA; COG0819 321967000825 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 321967000826 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 321967000827 substrate binding site [chemical binding]; other site 321967000828 multimerization interface [polypeptide binding]; other site 321967000829 ATP binding site [chemical binding]; other site 321967000830 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 321967000831 thiamine phosphate binding site [chemical binding]; other site 321967000832 active site 321967000833 pyrophosphate binding site [ion binding]; other site 321967000834 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 321967000835 dimer interface [polypeptide binding]; other site 321967000836 substrate binding site [chemical binding]; other site 321967000837 ATP binding site [chemical binding]; other site 321967000838 Amino acid permease; Region: AA_permease_2; pfam13520 321967000839 similar to hypothetical protein 321967000840 Transcriptional regulators [Transcription]; Region: PurR; COG1609 321967000841 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 321967000842 DNA binding site [nucleotide binding] 321967000843 domain linker motif; other site 321967000844 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 321967000845 ligand binding site [chemical binding]; other site 321967000846 dimerization interface [polypeptide binding]; other site 321967000847 D-ribose pyranase; Provisional; Region: PRK11797 321967000848 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 321967000849 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 321967000850 Walker A/P-loop; other site 321967000851 ATP binding site [chemical binding]; other site 321967000852 Q-loop/lid; other site 321967000853 ABC transporter signature motif; other site 321967000854 Walker B; other site 321967000855 D-loop; other site 321967000856 H-loop/switch region; other site 321967000857 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 321967000858 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 321967000859 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 321967000860 TM-ABC transporter signature motif; other site 321967000861 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 321967000862 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 321967000863 ligand binding site [chemical binding]; other site 321967000864 dimerization interface [polypeptide binding]; other site 321967000865 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967000866 Integrase core domain; Region: rve; pfam00665 321967000867 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 321967000868 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 321967000869 substrate binding site [chemical binding]; other site 321967000870 dimer interface [polypeptide binding]; other site 321967000871 ATP binding site [chemical binding]; other site 321967000872 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 321967000873 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 321967000874 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 321967000875 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 321967000876 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 321967000877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967000878 Major Facilitator Superfamily; Region: MFS_1; pfam07690 321967000879 putative substrate translocation pore; other site 321967000880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967000881 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 321967000882 MarR family; Region: MarR_2; pfam12802 321967000883 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967000884 Integrase core domain; Region: rve; pfam00665 321967000885 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 321967000886 L-aspartate oxidase; Provisional; Region: PRK06175 321967000887 Predicted oxidoreductase [General function prediction only]; Region: COG3573 321967000888 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 321967000889 Mga helix-turn-helix domain; Region: Mga; pfam05043 321967000890 PRD domain; Region: PRD; pfam00874 321967000891 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 321967000892 active site 321967000893 P-loop; other site 321967000894 phosphorylation site [posttranslational modification] 321967000895 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 321967000896 active site 321967000897 phosphorylation site [posttranslational modification] 321967000898 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 321967000899 active site 321967000900 P-loop; other site 321967000901 phosphorylation site [posttranslational modification] 321967000902 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 321967000903 Fructose-bisphosphate aldolase class-II; Region: F_bP_aldolase; pfam01116 321967000904 active site 321967000905 intersubunit interface [polypeptide binding]; other site 321967000906 zinc binding site [ion binding]; other site 321967000907 Na+ binding site [ion binding]; other site 321967000908 AAA domain; Region: AAA_17; pfam13207 321967000909 AAA domain; Region: AAA_18; pfam13238 321967000910 Predicted transcriptional regulators [Transcription]; Region: COG1378 321967000911 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 321967000912 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 321967000913 C-terminal domain interface [polypeptide binding]; other site 321967000914 sugar binding site [chemical binding]; other site 321967000915 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 321967000916 ornithine cyclodeaminase; Validated; Region: PRK08618 321967000917 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 321967000918 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967000919 Integrase core domain; Region: rve; pfam00665 321967000920 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 321967000921 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 321967000922 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 321967000923 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 321967000924 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 321967000925 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 321967000926 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 321967000927 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 321967000928 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 321967000929 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 321967000930 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 321967000931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 321967000932 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 321967000933 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967000934 Coenzyme A binding pocket [chemical binding]; other site 321967000935 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 321967000936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 321967000937 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 321967000938 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 321967000939 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 321967000940 Cl binding site [ion binding]; other site 321967000941 oligomer interface [polypeptide binding]; other site 321967000942 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 321967000943 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 321967000944 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 321967000945 catalytic residues [active] 321967000946 catalytic nucleophile [active] 321967000947 Presynaptic Site I dimer interface [polypeptide binding]; other site 321967000948 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 321967000949 Synaptic Flat tetramer interface [polypeptide binding]; other site 321967000950 Synaptic Site I dimer interface [polypeptide binding]; other site 321967000951 DNA binding site [nucleotide binding] 321967000952 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 321967000953 DNA-binding interface [nucleotide binding]; DNA binding site 321967000954 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 321967000955 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 321967000956 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 321967000957 DDE domain; Region: DDE_Tnp_IS240; pfam13610 321967000958 Integrase core domain; Region: rve; pfam00665 321967000959 helicase Cas3; Provisional; Region: PRK09694 321967000960 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 321967000961 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 321967000962 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 321967000963 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 321967000964 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 321967000965 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 321967000966 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 321967000967 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 321967000968 CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI; Region: cas1_ECOLI; TIGR03638 321967000969 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 321967000970 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 321967000971 active site 321967000972 catalytic site [active] 321967000973 substrate binding site [chemical binding]; other site 321967000974 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 321967000975 MobA/MobL family; Region: MobA_MobL; pfam03389 321967000976 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 321967000977 Homeodomain-like domain; Region: HTH_23; pfam13384 321967000978 Transposase; Region: DDE_Tnp_ISL3; pfam01610 321967000979 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967000980 Integrase core domain; Region: rve; pfam00665 321967000981 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 321967000982 conserved hypothetical protein; Region: TIGR02328 321967000983 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 321967000984 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967000985 Integrase core domain; Region: rve; pfam00665 321967000986 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 321967000987 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 321967000988 putative translaldolase; Provisional; Region: PRK12376 321967000989 catalytic residue [active] 321967000990 Transcriptional regulators [Transcription]; Region: PurR; COG1609 321967000991 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 321967000992 DNA binding site [nucleotide binding] 321967000993 domain linker motif; other site 321967000994 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 321967000995 dimerization interface [polypeptide binding]; other site 321967000996 ligand binding site [chemical binding]; other site 321967000997 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 321967000998 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 321967000999 NAD binding site [chemical binding]; other site 321967001000 sugar binding site [chemical binding]; other site 321967001001 divalent metal binding site [ion binding]; other site 321967001002 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 321967001003 dimer interface [polypeptide binding]; other site 321967001004 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 321967001005 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 321967001006 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 321967001007 active site turn [active] 321967001008 phosphorylation site [posttranslational modification] 321967001009 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 321967001010 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 321967001011 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 321967001012 putative active site [active] 321967001013 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 321967001014 HPr interaction site; other site 321967001015 glycerol kinase (GK) interaction site [polypeptide binding]; other site 321967001016 active site 321967001017 phosphorylation site [posttranslational modification] 321967001018 beta-phosphoglucomutase; Region: bPGM; TIGR01990 321967001019 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967001020 motif II; other site 321967001021 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 321967001022 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 321967001023 DNA-binding site [nucleotide binding]; DNA binding site 321967001024 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 321967001025 substrate binding pocket [chemical binding]; other site 321967001026 membrane-bound complex binding site; other site 321967001027 hinge residues; other site 321967001028 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 321967001029 Protein of unknown function; Region: YhfT; pfam10797 321967001030 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 321967001031 active site 321967001032 substrate binding pocket [chemical binding]; other site 321967001033 homodimer interaction site [polypeptide binding]; other site 321967001034 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 321967001035 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 321967001036 catalytic residue [active] 321967001037 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 321967001038 dimer interface [polypeptide binding]; other site 321967001039 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 321967001040 active site 321967001041 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 321967001042 substrate binding site [chemical binding]; other site 321967001043 catalytic residue [active] 321967001044 putative mutase; Provisional; Region: PRK12383 321967001045 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 321967001046 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 321967001047 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 321967001048 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 321967001049 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 321967001050 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 321967001051 inner membrane transporter YjeM; Provisional; Region: PRK15238 321967001052 lysine transporter; Provisional; Region: PRK10836 321967001053 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967001054 Integrase core domain; Region: rve; pfam00665 321967001055 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 321967001056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967001057 putative substrate translocation pore; other site 321967001058 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 321967001059 YvrJ protein family; Region: YvrJ; pfam12841 321967001060 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 321967001061 active site 321967001062 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 321967001063 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 321967001064 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 321967001065 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 321967001066 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 321967001067 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 321967001068 FtsX-like permease family; Region: FtsX; pfam02687 321967001069 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 321967001070 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 321967001071 Walker A/P-loop; other site 321967001072 ATP binding site [chemical binding]; other site 321967001073 Q-loop/lid; other site 321967001074 ABC transporter signature motif; other site 321967001075 Walker B; other site 321967001076 D-loop; other site 321967001077 H-loop/switch region; other site 321967001078 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 321967001079 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 321967001080 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967001081 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 321967001082 active site 321967001083 motif I; other site 321967001084 motif II; other site 321967001085 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 321967001086 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 321967001087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 321967001088 Transcriptional regulators [Transcription]; Region: PurR; COG1609 321967001089 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 321967001090 DNA binding site [nucleotide binding] 321967001091 domain linker motif; other site 321967001092 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 321967001093 putative dimerization interface [polypeptide binding]; other site 321967001094 putative ligand binding site [chemical binding]; other site 321967001095 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 321967001096 active site 321967001097 phosphorylation site [posttranslational modification] 321967001098 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 321967001099 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 321967001100 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 321967001101 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 321967001102 putative active site [active] 321967001103 putative catalytic site [active] 321967001104 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 321967001105 active pocket/dimerization site; other site 321967001106 active site 321967001107 phosphorylation site [posttranslational modification] 321967001108 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 321967001109 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 321967001110 Ca binding site [ion binding]; other site 321967001111 active site 321967001112 catalytic site [active] 321967001113 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 321967001114 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 321967001115 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 321967001116 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 321967001117 Walker A/P-loop; other site 321967001118 ATP binding site [chemical binding]; other site 321967001119 Q-loop/lid; other site 321967001120 ABC transporter signature motif; other site 321967001121 Walker B; other site 321967001122 D-loop; other site 321967001123 H-loop/switch region; other site 321967001124 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 321967001125 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 321967001126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967001127 Walker A/P-loop; other site 321967001128 ATP binding site [chemical binding]; other site 321967001129 Q-loop/lid; other site 321967001130 ABC transporter signature motif; other site 321967001131 Walker B; other site 321967001132 D-loop; other site 321967001133 H-loop/switch region; other site 321967001134 Predicted membrane protein [Function unknown]; Region: COG1511 321967001135 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 321967001136 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 321967001137 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 321967001138 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 321967001139 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 321967001140 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 321967001141 active site 321967001142 Winged helix-turn helix; Region: HTH_29; pfam13551 321967001143 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 321967001144 DNA-binding interface [nucleotide binding]; DNA binding site 321967001145 putative transposase OrfB; Reviewed; Region: PHA02517 321967001146 HTH-like domain; Region: HTH_21; pfam13276 321967001147 Integrase core domain; Region: rve; pfam00665 321967001148 Integrase core domain; Region: rve_2; pfam13333 321967001149 myosin-cross-reactive antigen; Provisional; Region: PRK13977 321967001150 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 321967001151 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 321967001152 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 321967001153 DAK2 domain; Region: Dak2; cl03685 321967001154 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 321967001155 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 321967001156 OsmC-like protein; Region: OsmC; cl00767 321967001157 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967001158 Integrase core domain; Region: rve; pfam00665 321967001159 Helix-turn-helix domain; Region: HTH_19; pfam12844 321967001160 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 321967001161 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 321967001162 active site 321967001163 catalytic site [active] 321967001164 substrate binding site [chemical binding]; other site 321967001165 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 321967001166 dimerization interface [polypeptide binding]; other site 321967001167 putative DNA binding site [nucleotide binding]; other site 321967001168 putative Zn2+ binding site [ion binding]; other site 321967001169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967001170 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 321967001171 putative substrate translocation pore; other site 321967001172 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 321967001173 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 321967001174 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 321967001175 intersubunit interface [polypeptide binding]; other site 321967001176 active site 321967001177 zinc binding site [ion binding]; other site 321967001178 Na+ binding site [ion binding]; other site 321967001179 pyruvate oxidase; Provisional; Region: PRK08611 321967001180 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 321967001181 PYR/PP interface [polypeptide binding]; other site 321967001182 dimer interface [polypeptide binding]; other site 321967001183 tetramer interface [polypeptide binding]; other site 321967001184 TPP binding site [chemical binding]; other site 321967001185 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 321967001186 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 321967001187 TPP-binding site [chemical binding]; other site 321967001188 Beta-lactamase; Region: Beta-lactamase; pfam00144 321967001189 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 321967001190 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 321967001191 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 321967001192 active site 321967001193 Methyltransferase domain; Region: Methyltransf_31; pfam13847 321967001194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967001195 S-adenosylmethionine binding site [chemical binding]; other site 321967001196 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 321967001197 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 321967001198 catalytic triad [active] 321967001199 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 321967001200 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 321967001201 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 321967001202 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 321967001203 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 321967001204 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 321967001205 DNA binding residues [nucleotide binding] 321967001206 putative dimer interface [polypeptide binding]; other site 321967001207 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 321967001208 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 321967001209 active site 321967001210 catalytic tetrad [active] 321967001211 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 321967001212 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 321967001213 putative NAD(P) binding site [chemical binding]; other site 321967001214 dimer interface [polypeptide binding]; other site 321967001215 Predicted transcriptional regulators [Transcription]; Region: COG1733 321967001216 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 321967001217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 321967001218 Homeodomain-like domain; Region: HTH_23; pfam13384 321967001219 Transposase; Region: DDE_Tnp_ISL3; pfam01610 321967001220 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 321967001221 beta-galactosidase; Region: BGL; TIGR03356 321967001222 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 321967001223 active site 321967001224 methionine cluster; other site 321967001225 phosphorylation site [posttranslational modification] 321967001226 metal binding site [ion binding]; metal-binding site 321967001227 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 321967001228 HTH domain; Region: HTH_11; cl17392 321967001229 Mga helix-turn-helix domain; Region: Mga; pfam05043 321967001230 PRD domain; Region: PRD; pfam00874 321967001231 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 321967001232 active site 321967001233 phosphorylation site [posttranslational modification] 321967001234 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 321967001235 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 321967001236 catalytic residues [active] 321967001237 catalytic nucleophile [active] 321967001238 Presynaptic Site I dimer interface [polypeptide binding]; other site 321967001239 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 321967001240 Synaptic Flat tetramer interface [polypeptide binding]; other site 321967001241 Synaptic Site I dimer interface [polypeptide binding]; other site 321967001242 DNA binding site [nucleotide binding] 321967001243 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 321967001244 metal ion-dependent adhesion site (MIDAS); other site 321967001245 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 321967001246 domain interaction interfaces [polypeptide binding]; other site 321967001247 Cna protein B-type domain; Region: Cna_B; pfam05738 321967001248 Cna protein B-type domain; Region: Cna_B; pfam05738 321967001249 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 321967001250 active site 321967001251 catalytic site [active] 321967001252 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 321967001253 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 321967001254 Walker A/P-loop; other site 321967001255 ATP binding site [chemical binding]; other site 321967001256 Q-loop/lid; other site 321967001257 ABC transporter signature motif; other site 321967001258 Walker B; other site 321967001259 D-loop; other site 321967001260 H-loop/switch region; other site 321967001261 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 321967001262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 321967001263 active site 321967001264 phosphorylation site [posttranslational modification] 321967001265 intermolecular recognition site; other site 321967001266 dimerization interface [polypeptide binding]; other site 321967001267 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 321967001268 DNA binding site [nucleotide binding] 321967001269 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 321967001270 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 321967001271 dimerization interface [polypeptide binding]; other site 321967001272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 321967001273 dimer interface [polypeptide binding]; other site 321967001274 phosphorylation site [posttranslational modification] 321967001275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 321967001276 ATP binding site [chemical binding]; other site 321967001277 Mg2+ binding site [ion binding]; other site 321967001278 G-X-G motif; other site 321967001279 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 321967001280 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 321967001281 Walker A/P-loop; other site 321967001282 ATP binding site [chemical binding]; other site 321967001283 Q-loop/lid; other site 321967001284 ABC transporter signature motif; other site 321967001285 Walker B; other site 321967001286 D-loop; other site 321967001287 H-loop/switch region; other site 321967001288 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 321967001289 RNA polymerase sigma factor; Provisional; Region: PRK05901 321967001290 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 321967001291 catalytic triad [active] 321967001292 putative active site [active] 321967001293 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 321967001294 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 321967001295 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 321967001296 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 321967001297 Zn binding site [ion binding]; other site 321967001298 inner membrane transporter YjeM; Provisional; Region: PRK15238 321967001299 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 321967001300 Transcriptional regulator [Transcription]; Region: LysR; COG0583 321967001301 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 321967001302 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 321967001303 putative dimerization interface [polypeptide binding]; other site 321967001304 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 321967001305 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 321967001306 classical (c) SDRs; Region: SDR_c; cd05233 321967001307 NAD(P) binding site [chemical binding]; other site 321967001308 active site 321967001309 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 321967001310 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 321967001311 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 321967001312 shikimate binding site; other site 321967001313 NAD(P) binding site [chemical binding]; other site 321967001314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967001315 putative substrate translocation pore; other site 321967001316 Major Facilitator Superfamily; Region: MFS_1; pfam07690 321967001317 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 321967001318 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 321967001319 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 321967001320 shikimate binding site; other site 321967001321 NAD(P) binding site [chemical binding]; other site 321967001322 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 321967001323 proposed active site lysine [active] 321967001324 conserved cys residue [active] 321967001325 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 321967001326 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 321967001327 dimer interface [polypeptide binding]; other site 321967001328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 321967001329 catalytic residue [active] 321967001330 Transposase; Region: HTH_Tnp_1; pfam01527 321967001331 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 321967001332 HTH-like domain; Region: HTH_21; pfam13276 321967001333 Integrase core domain; Region: rve; pfam00665 321967001334 Integrase core domain; Region: rve_3; cl15866 321967001335 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 321967001336 Int/Topo IB signature motif; other site 321967001337 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 321967001338 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 321967001339 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967001340 non-specific DNA binding site [nucleotide binding]; other site 321967001341 salt bridge; other site 321967001342 sequence-specific DNA binding site [nucleotide binding]; other site 321967001343 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 321967001344 ORF6N domain; Region: ORF6N; pfam10543 321967001345 ORF6C domain; Region: ORF6C; pfam10552 321967001346 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 321967001347 Domain of unknown function (DUF771); Region: DUF771; pfam05595 321967001348 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 321967001349 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967001350 Integrase core domain; Region: rve; pfam00665 321967001351 Helix-turn-helix domain; Region: HTH_36; pfam13730 321967001352 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 321967001353 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 321967001354 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 321967001355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 321967001356 Walker A motif; other site 321967001357 ATP binding site [chemical binding]; other site 321967001358 Walker B motif; other site 321967001359 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 321967001360 active site 321967001361 catalytic site [active] 321967001362 substrate binding site [chemical binding]; other site 321967001363 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 321967001364 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 321967001365 active site 321967001366 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967001367 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967001368 Integrase core domain; Region: rve; pfam00665 321967001369 GcrA cell cycle regulator; Region: GcrA; cl11564 321967001370 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 321967001371 Transposase; Region: HTH_Tnp_1; pfam01527 321967001372 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 321967001373 HTH-like domain; Region: HTH_21; pfam13276 321967001374 Integrase core domain; Region: rve; pfam00665 321967001375 Integrase core domain; Region: rve_3; cl15866 321967001376 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 321967001377 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 321967001378 generic binding surface II; other site 321967001379 generic binding surface I; other site 321967001380 AAA-like domain; Region: AAA_10; pfam12846 321967001381 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 321967001382 Walker A motif; other site 321967001383 ATP binding site [chemical binding]; other site 321967001384 Walker B motif; other site 321967001385 AAA-like domain; Region: AAA_10; pfam12846 321967001386 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 321967001387 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 321967001388 NlpC/P60 family; Region: NLPC_P60; cl17555 321967001389 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 321967001390 catalytic residues [active] 321967001391 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 321967001392 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 321967001393 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 321967001394 Toprim-like; Region: Toprim_2; pfam13155 321967001395 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 321967001396 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 321967001397 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 321967001398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 321967001399 Transcriptional antiterminator [Transcription]; Region: COG3933 321967001400 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 321967001401 active pocket/dimerization site; other site 321967001402 active site 321967001403 phosphorylation site [posttranslational modification] 321967001404 PRD domain; Region: PRD; pfam00874 321967001405 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 321967001406 active pocket/dimerization site; other site 321967001407 active site 321967001408 phosphorylation site [posttranslational modification] 321967001409 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 321967001410 active site 321967001411 phosphorylation site [posttranslational modification] 321967001412 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 321967001413 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 321967001414 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 321967001415 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 321967001416 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 321967001417 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 321967001418 substrate binding [chemical binding]; other site 321967001419 active site 321967001420 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 321967001421 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 321967001422 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 321967001423 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 321967001424 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967001425 Integrase core domain; Region: rve; pfam00665 321967001426 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967001427 Integrase core domain; Region: rve; pfam00665 321967001428 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 321967001429 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 321967001430 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 321967001431 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 321967001432 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 321967001433 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 321967001434 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 321967001435 catalytic residues [active] 321967001436 catalytic nucleophile [active] 321967001437 Presynaptic Site I dimer interface [polypeptide binding]; other site 321967001438 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 321967001439 Synaptic Flat tetramer interface [polypeptide binding]; other site 321967001440 Synaptic Site I dimer interface [polypeptide binding]; other site 321967001441 DNA binding site [nucleotide binding] 321967001442 Transposase domain (DUF772); Region: DUF772; pfam05598 321967001443 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 321967001444 dimer interface [polypeptide binding]; other site 321967001445 FMN binding site [chemical binding]; other site 321967001446 NADPH bind site [chemical binding]; other site 321967001447 Transposase domain (DUF772); Region: DUF772; pfam05598 321967001448 DEAD-like helicases superfamily; Region: DEXDc; smart00487 321967001449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 321967001450 ATP binding site [chemical binding]; other site 321967001451 putative Mg++ binding site [ion binding]; other site 321967001452 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 321967001453 DNA methylase; Region: N6_N4_Mtase; pfam01555 321967001454 DNA methylase; Region: N6_N4_Mtase; pfam01555 321967001455 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967001456 Integrase core domain; Region: rve; pfam00665 321967001457 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 321967001458 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 321967001459 transmembrane helices; other site 321967001460 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 321967001461 DDE domain; Region: DDE_Tnp_IS240; pfam13610 321967001462 Integrase core domain; Region: rve; pfam00665 321967001463 Integrase core domain; Region: rve_3; pfam13683 321967001464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 321967001465 Transposase; Region: HTH_Tnp_1; pfam01527 321967001466 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 321967001467 ApbE family; Region: ApbE; pfam02424 321967001468 Predicted flavoprotein [General function prediction only]; Region: COG0431 321967001469 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 321967001470 Predicted flavoprotein [General function prediction only]; Region: COG0431 321967001471 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 321967001472 PAS domain; Region: PAS_10; pfam13596 321967001473 Transposase; Region: HTH_Tnp_1; pfam01527 321967001474 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 321967001475 HTH-like domain; Region: HTH_21; pfam13276 321967001476 Integrase core domain; Region: rve; pfam00665 321967001477 Integrase core domain; Region: rve_3; cl15866 321967001478 Transposase domain (DUF772); Region: DUF772; pfam05598 321967001479 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 321967001480 active site 321967001481 Bacterial SH3 domain; Region: SH3_5; pfam08460 321967001482 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 321967001483 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 321967001484 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 321967001485 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 321967001486 homodimer interface [polypeptide binding]; other site 321967001487 substrate-cofactor binding pocket; other site 321967001488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 321967001489 catalytic residue [active] 321967001490 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 321967001491 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 321967001492 substrate binding pocket [chemical binding]; other site 321967001493 membrane-bound complex binding site; other site 321967001494 hinge residues; other site 321967001495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967001496 dimer interface [polypeptide binding]; other site 321967001497 conserved gate region; other site 321967001498 putative PBP binding loops; other site 321967001499 ABC-ATPase subunit interface; other site 321967001500 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 321967001501 WxL domain surface cell wall-binding; Region: WxL; pfam13731 321967001502 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 321967001503 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 321967001504 Transposase domain (DUF772); Region: DUF772; pfam05598 321967001505 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967001506 Integrase core domain; Region: rve; pfam00665 321967001507 WxL domain surface cell wall-binding; Region: WxL; pfam13731 321967001508 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 321967001509 WxL domain surface cell wall-binding; Region: WxL; pfam13731 321967001510 legume lectins; Region: lectin_L-type; cd01951 321967001511 homotetramer interaction site [polypeptide binding]; other site 321967001512 carbohydrate binding site [chemical binding]; other site 321967001513 metal binding site [ion binding]; metal-binding site 321967001514 WxL domain surface cell wall-binding; Region: WxL; pfam13731 321967001515 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 321967001516 EamA-like transporter family; Region: EamA; pfam00892 321967001517 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 321967001518 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 321967001519 Walker A/P-loop; other site 321967001520 ATP binding site [chemical binding]; other site 321967001521 Q-loop/lid; other site 321967001522 ABC transporter signature motif; other site 321967001523 Walker B; other site 321967001524 D-loop; other site 321967001525 H-loop/switch region; other site 321967001526 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 321967001527 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 321967001528 substrate binding site [chemical binding]; other site 321967001529 ATP binding site [chemical binding]; other site 321967001530 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 321967001531 FAD binding site [chemical binding]; other site 321967001532 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 321967001533 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 321967001534 THF binding site; other site 321967001535 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 321967001536 substrate binding site [chemical binding]; other site 321967001537 THF binding site; other site 321967001538 zinc-binding site [ion binding]; other site 321967001539 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 321967001540 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 321967001541 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967001542 Walker A/P-loop; other site 321967001543 ATP binding site [chemical binding]; other site 321967001544 Q-loop/lid; other site 321967001545 ABC transporter signature motif; other site 321967001546 Walker B; other site 321967001547 D-loop; other site 321967001548 H-loop/switch region; other site 321967001549 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 321967001550 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 321967001551 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 321967001552 Walker A/P-loop; other site 321967001553 ATP binding site [chemical binding]; other site 321967001554 Q-loop/lid; other site 321967001555 ABC transporter signature motif; other site 321967001556 Walker B; other site 321967001557 D-loop; other site 321967001558 H-loop/switch region; other site 321967001559 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 321967001560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967001561 putative substrate translocation pore; other site 321967001562 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 321967001563 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 321967001564 DNA-binding site [nucleotide binding]; DNA binding site 321967001565 UTRA domain; Region: UTRA; pfam07702 321967001566 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 321967001567 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 321967001568 Ca binding site [ion binding]; other site 321967001569 active site 321967001570 catalytic site [active] 321967001571 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 321967001572 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 321967001573 HPr interaction site; other site 321967001574 glycerol kinase (GK) interaction site [polypeptide binding]; other site 321967001575 active site 321967001576 phosphorylation site [posttranslational modification] 321967001577 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 321967001578 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 321967001579 active site turn [active] 321967001580 phosphorylation site [posttranslational modification] 321967001581 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 321967001582 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 321967001583 serine/threonine transporter SstT; Provisional; Region: PRK13628 321967001584 amino acid transporter; Region: 2A0306; TIGR00909 321967001585 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 321967001586 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 321967001587 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 321967001588 NAD binding site [chemical binding]; other site 321967001589 dimer interface [polypeptide binding]; other site 321967001590 tetramer (dimer of dimers) interface [polypeptide binding]; other site 321967001591 substrate binding site [chemical binding]; other site 321967001592 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 321967001593 DNA-binding site [nucleotide binding]; DNA binding site 321967001594 RNA-binding motif; other site 321967001595 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 321967001596 OsmC-like protein; Region: OsmC; pfam02566 321967001597 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 321967001598 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 321967001599 ABC transporter; Region: ABC_tran_2; pfam12848 321967001600 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 321967001601 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 321967001602 NADH(P)-binding; Region: NAD_binding_10; pfam13460 321967001603 NAD(P) binding site [chemical binding]; other site 321967001604 putative active site [active] 321967001605 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 321967001606 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 321967001607 active site 321967001608 catalytic tetrad [active] 321967001609 putative transport protein YifK; Provisional; Region: PRK10746 321967001610 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 321967001611 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 321967001612 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 321967001613 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 321967001614 LytTr DNA-binding domain; Region: LytTR; smart00850 321967001615 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 321967001616 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 321967001617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967001618 Walker A/P-loop; other site 321967001619 ATP binding site [chemical binding]; other site 321967001620 Q-loop/lid; other site 321967001621 ABC transporter signature motif; other site 321967001622 Walker B; other site 321967001623 D-loop; other site 321967001624 H-loop/switch region; other site 321967001625 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 321967001626 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 321967001627 active site 321967001628 zinc binding site [ion binding]; other site 321967001629 hypothetical protein; Provisional; Region: PRK00967 321967001630 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 321967001631 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 321967001632 putative NAD(P) binding site [chemical binding]; other site 321967001633 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 321967001634 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 321967001635 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 321967001636 MgtC family; Region: MgtC; pfam02308 321967001637 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 321967001638 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 321967001639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967001640 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 321967001641 Walker A/P-loop; other site 321967001642 ATP binding site [chemical binding]; other site 321967001643 Q-loop/lid; other site 321967001644 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 321967001645 ABC transporter; Region: ABC_tran_2; pfam12848 321967001646 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 321967001647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967001648 Walker A/P-loop; other site 321967001649 ATP binding site [chemical binding]; other site 321967001650 Q-loop/lid; other site 321967001651 ABC transporter signature motif; other site 321967001652 Walker B; other site 321967001653 D-loop; other site 321967001654 H-loop/switch region; other site 321967001655 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 321967001656 putative uracil binding site [chemical binding]; other site 321967001657 putative active site [active] 321967001658 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 321967001659 amphipathic channel; other site 321967001660 Asn-Pro-Ala signature motifs; other site 321967001661 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 321967001662 glycerol kinase; Provisional; Region: glpK; PRK00047 321967001663 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 321967001664 N- and C-terminal domain interface [polypeptide binding]; other site 321967001665 active site 321967001666 MgATP binding site [chemical binding]; other site 321967001667 catalytic site [active] 321967001668 metal binding site [ion binding]; metal-binding site 321967001669 glycerol binding site [chemical binding]; other site 321967001670 homotetramer interface [polypeptide binding]; other site 321967001671 homodimer interface [polypeptide binding]; other site 321967001672 FBP binding site [chemical binding]; other site 321967001673 protein IIAGlc interface [polypeptide binding]; other site 321967001674 galactokinase; Provisional; Region: PRK05322 321967001675 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 321967001676 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 321967001677 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 321967001678 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 321967001679 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 321967001680 NAD binding site [chemical binding]; other site 321967001681 homodimer interface [polypeptide binding]; other site 321967001682 active site 321967001683 substrate binding site [chemical binding]; other site 321967001684 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 321967001685 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 321967001686 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 321967001687 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 321967001688 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 321967001689 DNA binding site [nucleotide binding] 321967001690 domain linker motif; other site 321967001691 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 321967001692 putative dimerization interface [polypeptide binding]; other site 321967001693 putative ligand binding site [chemical binding]; other site 321967001694 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 321967001695 active site 321967001696 catalytic residues [active] 321967001697 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 321967001698 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 321967001699 active site 321967001700 phosphorylation site [posttranslational modification] 321967001701 Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414 321967001702 active site 321967001703 P-loop; other site 321967001704 phosphorylation site [posttranslational modification] 321967001705 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 321967001706 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 321967001707 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 321967001708 putative substrate binding site [chemical binding]; other site 321967001709 putative ATP binding site [chemical binding]; other site 321967001710 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 321967001711 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 321967001712 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 321967001713 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 321967001714 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 321967001715 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 321967001716 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 321967001717 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967001718 motif II; other site 321967001719 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 321967001720 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 321967001721 active site 321967001722 metal binding site [ion binding]; metal-binding site 321967001723 DNA binding site [nucleotide binding] 321967001724 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 321967001725 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 321967001726 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 321967001727 Walker A/P-loop; other site 321967001728 ATP binding site [chemical binding]; other site 321967001729 Q-loop/lid; other site 321967001730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967001731 ABC transporter signature motif; other site 321967001732 Walker B; other site 321967001733 D-loop; other site 321967001734 H-loop/switch region; other site 321967001735 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 321967001736 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 321967001737 putative dimer interface [polypeptide binding]; other site 321967001738 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 321967001739 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 321967001740 minor groove reading motif; other site 321967001741 helix-hairpin-helix signature motif; other site 321967001742 substrate binding pocket [chemical binding]; other site 321967001743 active site 321967001744 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 321967001745 DNA binding and oxoG recognition site [nucleotide binding] 321967001746 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 321967001747 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 321967001748 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 321967001749 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 321967001750 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 321967001751 dimer interface [polypeptide binding]; other site 321967001752 substrate binding site [chemical binding]; other site 321967001753 ATP binding site [chemical binding]; other site 321967001754 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 321967001755 NADH(P)-binding; Region: NAD_binding_10; pfam13460 321967001756 NAD binding site [chemical binding]; other site 321967001757 substrate binding site [chemical binding]; other site 321967001758 putative active site [active] 321967001759 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 321967001760 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 321967001761 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 321967001762 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 321967001763 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 321967001764 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 321967001765 zinc binding site [ion binding]; other site 321967001766 putative ligand binding site [chemical binding]; other site 321967001767 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 321967001768 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 321967001769 zinc binding site [ion binding]; other site 321967001770 putative ligand binding site [chemical binding]; other site 321967001771 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 321967001772 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 321967001773 TM-ABC transporter signature motif; other site 321967001774 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 321967001775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967001776 Walker A/P-loop; other site 321967001777 ATP binding site [chemical binding]; other site 321967001778 Q-loop/lid; other site 321967001779 ABC transporter signature motif; other site 321967001780 Walker B; other site 321967001781 D-loop; other site 321967001782 H-loop/switch region; other site 321967001783 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 321967001784 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 321967001785 NADP binding site [chemical binding]; other site 321967001786 dimer interface [polypeptide binding]; other site 321967001787 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 321967001788 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 321967001789 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 321967001790 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 321967001791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967001792 motif II; other site 321967001793 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 321967001794 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 321967001795 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 321967001796 Ligand binding site; other site 321967001797 Putative Catalytic site; other site 321967001798 DXD motif; other site 321967001799 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 321967001800 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 321967001801 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 321967001802 Predicted membrane protein [Function unknown]; Region: COG2246 321967001803 GtrA-like protein; Region: GtrA; pfam04138 321967001804 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 321967001805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 321967001806 active site 321967001807 phosphorylation site [posttranslational modification] 321967001808 intermolecular recognition site; other site 321967001809 dimerization interface [polypeptide binding]; other site 321967001810 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 321967001811 DNA binding site [nucleotide binding] 321967001812 Di-sulfide bridge nucleocytoplasmic transport domain; Region: Brr6_like_C_C; cl12377 321967001813 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 321967001814 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 321967001815 dimer interface [polypeptide binding]; other site 321967001816 phosphorylation site [posttranslational modification] 321967001817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 321967001818 ATP binding site [chemical binding]; other site 321967001819 Mg2+ binding site [ion binding]; other site 321967001820 G-X-G motif; other site 321967001821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 321967001822 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 321967001823 hypothetical protein; Provisional; Region: PRK06194 321967001824 classical (c) SDRs; Region: SDR_c; cd05233 321967001825 NAD(P) binding site [chemical binding]; other site 321967001826 active site 321967001827 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 321967001828 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 321967001829 dimer interface [polypeptide binding]; other site 321967001830 FMN binding site [chemical binding]; other site 321967001831 Predicted transcriptional regulators [Transcription]; Region: COG1695 321967001832 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 321967001833 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 321967001834 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 321967001835 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 321967001836 putative NAD(P) binding site [chemical binding]; other site 321967001837 dimer interface [polypeptide binding]; other site 321967001838 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 321967001839 Domain of unknown function DUF20; Region: UPF0118; pfam01594 321967001840 LexA repressor; Validated; Region: PRK00215 321967001841 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 321967001842 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 321967001843 Catalytic site [active] 321967001844 Membrane transport protein; Region: Mem_trans; pfam03547 321967001845 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 321967001846 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 321967001847 Uncharacterized conserved protein [Function unknown]; Region: COG3189 321967001848 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 321967001849 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 321967001850 Cl binding site [ion binding]; other site 321967001851 oligomer interface [polypeptide binding]; other site 321967001852 Transcriptional regulator [Transcription]; Region: LysR; COG0583 321967001853 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 321967001854 The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437 321967001855 putative dimerization interface [polypeptide binding]; other site 321967001856 malate dehydrogenase; Provisional; Region: PRK13529 321967001857 Malic enzyme, N-terminal domain; Region: malic; pfam00390 321967001858 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 321967001859 NAD(P) binding site [chemical binding]; other site 321967001860 Membrane transport protein; Region: Mem_trans; pfam03547 321967001861 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 321967001862 dimer interface [polypeptide binding]; other site 321967001863 catalytic triad [active] 321967001864 peroxidatic and resolving cysteines [active] 321967001865 Flavodoxin domain; Region: Flavodoxin_5; cl17428 321967001866 oligoendopeptidase F; Region: pepF; TIGR00181 321967001867 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 321967001868 active site 321967001869 Zn binding site [ion binding]; other site 321967001870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 321967001871 glucose-1-dehydrogenase; Provisional; Region: PRK06947 321967001872 NAD(P) binding site [chemical binding]; other site 321967001873 active site 321967001874 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 321967001875 active site 321967001876 multimer interface [polypeptide binding]; other site 321967001877 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 321967001878 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 321967001879 Soluble P-type ATPase [General function prediction only]; Region: COG4087 321967001880 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 321967001881 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 321967001882 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 321967001883 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 321967001884 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 321967001885 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967001886 motif II; other site 321967001887 Transcriptional regulators [Transcription]; Region: MarR; COG1846 321967001888 MarR family; Region: MarR_2; pfam12802 321967001889 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 321967001890 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 321967001891 flavoprotein NrdI; Provisional; Region: PRK02551 321967001892 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 321967001893 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 321967001894 active site 321967001895 catalytic tetrad [active] 321967001896 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 321967001897 Predicted membrane protein [Function unknown]; Region: COG2323 321967001898 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 321967001899 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 321967001900 substrate binding site [chemical binding]; other site 321967001901 THF binding site; other site 321967001902 zinc-binding site [ion binding]; other site 321967001903 S-ribosylhomocysteinase; Provisional; Region: PRK02260 321967001904 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967001905 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967001906 Integrase core domain; Region: rve; pfam00665 321967001907 Uncharacterized conserved protein [Function unknown]; Region: COG0398 321967001908 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 321967001909 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 321967001910 RuvA N terminal domain; Region: RuvA_N; pfam01330 321967001911 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 321967001912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 321967001913 Walker A motif; other site 321967001914 ATP binding site [chemical binding]; other site 321967001915 Walker B motif; other site 321967001916 arginine finger; other site 321967001917 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 321967001918 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 321967001919 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 321967001920 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 321967001921 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 321967001922 Preprotein translocase subunit; Region: YajC; pfam02699 321967001923 putative transposase OrfB; Reviewed; Region: PHA02517 321967001924 HTH-like domain; Region: HTH_21; pfam13276 321967001925 Integrase core domain; Region: rve; pfam00665 321967001926 Integrase core domain; Region: rve_3; pfam13683 321967001927 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 321967001928 Transposase; Region: HTH_Tnp_1; pfam01527 321967001929 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 321967001930 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 321967001931 putative catalytic cysteine [active] 321967001932 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 321967001933 putative active site [active] 321967001934 metal binding site [ion binding]; metal-binding site 321967001935 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 321967001936 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 321967001937 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 321967001938 FeoA domain; Region: FeoA; pfam04023 321967001939 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 321967001940 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 321967001941 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 321967001942 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 321967001943 active site 321967001944 DNA polymerase IV; Validated; Region: PRK02406 321967001945 DNA binding site [nucleotide binding] 321967001946 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 321967001947 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 321967001948 DNA-binding site [nucleotide binding]; DNA binding site 321967001949 DRTGG domain; Region: DRTGG; pfam07085 321967001950 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 321967001951 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 321967001952 DHH family; Region: DHH; pfam01368 321967001953 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 321967001954 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 321967001955 ATP binding site [chemical binding]; other site 321967001956 Mg++ binding site [ion binding]; other site 321967001957 motif III; other site 321967001958 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 321967001959 nucleotide binding region [chemical binding]; other site 321967001960 ATP-binding site [chemical binding]; other site 321967001961 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 321967001962 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 321967001963 motif 1; other site 321967001964 active site 321967001965 motif 2; other site 321967001966 motif 3; other site 321967001967 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 321967001968 DHHA1 domain; Region: DHHA1; pfam02272 321967001969 hypothetical protein; Provisional; Region: PRK05473 321967001970 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 321967001971 hypothetical protein; Provisional; Region: PRK13678 321967001972 Cell division protein ZapA; Region: ZapA; pfam05164 321967001973 Colicin V production protein; Region: Colicin_V; pfam02674 321967001974 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 321967001975 MutS domain III; Region: MutS_III; pfam05192 321967001976 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967001977 Walker A/P-loop; other site 321967001978 ATP binding site [chemical binding]; other site 321967001979 Q-loop/lid; other site 321967001980 ABC transporter signature motif; other site 321967001981 Walker B; other site 321967001982 D-loop; other site 321967001983 H-loop/switch region; other site 321967001984 V-type ATP synthase subunit H; Validated; Region: PRK06397 321967001985 Smr domain; Region: Smr; pfam01713 321967001986 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 321967001987 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 321967001988 catalytic residues [active] 321967001989 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 321967001990 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 321967001991 acyl-activating enzyme (AAE) consensus motif; other site 321967001992 AMP binding site [chemical binding]; other site 321967001993 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 321967001994 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 321967001995 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 321967001996 DltD N-terminal region; Region: DltD_N; pfam04915 321967001997 DltD central region; Region: DltD_M; pfam04918 321967001998 DltD C-terminal region; Region: DltD_C; pfam04914 321967001999 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 321967002000 glutamate racemase; Provisional; Region: PRK00865 321967002001 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 321967002002 active site 321967002003 dimerization interface [polypeptide binding]; other site 321967002004 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 321967002005 active site 321967002006 metal binding site [ion binding]; metal-binding site 321967002007 homotetramer interface [polypeptide binding]; other site 321967002008 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 321967002009 amphipathic channel; other site 321967002010 Asn-Pro-Ala signature motifs; other site 321967002011 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 321967002012 FOG: CBS domain [General function prediction only]; Region: COG0517 321967002013 Domain of unknown function (DUF368); Region: DUF368; pfam04018 321967002014 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 321967002015 Mechanosensitive ion channel; Region: MS_channel; pfam00924 321967002016 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 321967002017 YtxH-like protein; Region: YtxH; pfam12732 321967002018 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 321967002019 HTH domain; Region: HTH_11; pfam08279 321967002020 3H domain; Region: 3H; pfam02829 321967002021 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 321967002022 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 321967002023 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 321967002024 active site 321967002025 catabolite control protein A; Region: ccpA; TIGR01481 321967002026 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 321967002027 DNA binding site [nucleotide binding] 321967002028 domain linker motif; other site 321967002029 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 321967002030 dimerization interface [polypeptide binding]; other site 321967002031 effector binding site; other site 321967002032 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 321967002033 Transglycosylase; Region: Transgly; pfam00912 321967002034 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 321967002035 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 321967002036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967002037 motif II; other site 321967002038 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 321967002039 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 321967002040 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 321967002041 dipeptidase PepV; Reviewed; Region: PRK07318 321967002042 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 321967002043 active site 321967002044 metal binding site [ion binding]; metal-binding site 321967002045 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 321967002046 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 321967002047 active site 321967002048 catalytic site [active] 321967002049 metal binding site [ion binding]; metal-binding site 321967002050 YibE/F-like protein; Region: YibE_F; pfam07907 321967002051 YibE/F-like protein; Region: YibE_F; pfam07907 321967002052 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 321967002053 putative active site [active] 321967002054 putative metal binding site [ion binding]; other site 321967002055 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 321967002056 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 321967002057 active site 321967002058 metal binding site [ion binding]; metal-binding site 321967002059 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 321967002060 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 321967002061 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 321967002062 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967002063 active site 321967002064 motif I; other site 321967002065 motif II; other site 321967002066 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967002067 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 321967002068 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 321967002069 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 321967002070 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 321967002071 tetramer interfaces [polypeptide binding]; other site 321967002072 binuclear metal-binding site [ion binding]; other site 321967002073 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 321967002074 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 321967002075 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 321967002076 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 321967002077 active site 321967002078 general stress protein 13; Validated; Region: PRK08059 321967002079 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 321967002080 RNA binding site [nucleotide binding]; other site 321967002081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 321967002082 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 321967002083 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 321967002084 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 321967002085 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 321967002086 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 321967002087 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 321967002088 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 321967002089 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 321967002090 putative ADP-binding pocket [chemical binding]; other site 321967002091 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 321967002092 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 321967002093 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 321967002094 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 321967002095 aromatic amino acid aminotransferase; Validated; Region: PRK07309 321967002096 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 321967002097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 321967002098 homodimer interface [polypeptide binding]; other site 321967002099 catalytic residue [active] 321967002100 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 321967002101 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 321967002102 Sulfatase; Region: Sulfatase; pfam00884 321967002103 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 321967002104 metal binding site 2 [ion binding]; metal-binding site 321967002105 putative DNA binding helix; other site 321967002106 metal binding site 1 [ion binding]; metal-binding site 321967002107 dimer interface [polypeptide binding]; other site 321967002108 structural Zn2+ binding site [ion binding]; other site 321967002109 S-adenosylmethionine synthetase; Validated; Region: PRK05250 321967002110 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 321967002111 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 321967002112 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 321967002113 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 321967002114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967002115 putative substrate translocation pore; other site 321967002116 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 321967002117 DNA binding residues [nucleotide binding] 321967002118 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 321967002119 putative dimer interface [polypeptide binding]; other site 321967002120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967002121 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 321967002122 putative substrate translocation pore; other site 321967002123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967002124 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 321967002125 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 321967002126 active site 321967002127 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 321967002128 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 321967002129 HIGH motif; other site 321967002130 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 321967002131 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 321967002132 active site 321967002133 KMSKS motif; other site 321967002134 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 321967002135 tRNA binding surface [nucleotide binding]; other site 321967002136 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 321967002137 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 321967002138 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 321967002139 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 321967002140 RNA binding surface [nucleotide binding]; other site 321967002141 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 321967002142 active site 321967002143 uracil binding [chemical binding]; other site 321967002144 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 321967002145 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 321967002146 putative substrate binding site [chemical binding]; other site 321967002147 putative ATP binding site [chemical binding]; other site 321967002148 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 321967002149 nudix motif; other site 321967002150 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 321967002151 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 321967002152 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 321967002153 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 321967002154 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 321967002155 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 321967002156 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 321967002157 catalytic residues [active] 321967002158 dimer interface [polypeptide binding]; other site 321967002159 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 321967002160 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 321967002161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 321967002162 homodimer interface [polypeptide binding]; other site 321967002163 catalytic residue [active] 321967002164 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 321967002165 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 321967002166 active site 321967002167 metal binding site [ion binding]; metal-binding site 321967002168 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 321967002169 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 321967002170 Competence protein CoiA-like family; Region: CoiA; cl11541 321967002171 Thioredoxin; Region: Thioredoxin_5; pfam13743 321967002172 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 321967002173 putative active site [active] 321967002174 putative metal binding residues [ion binding]; other site 321967002175 signature motif; other site 321967002176 putative triphosphate binding site [ion binding]; other site 321967002177 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 321967002178 synthetase active site [active] 321967002179 NTP binding site [chemical binding]; other site 321967002180 metal binding site [ion binding]; metal-binding site 321967002181 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 321967002182 ATP-NAD kinase; Region: NAD_kinase; pfam01513 321967002183 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 321967002184 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 321967002185 RNA binding surface [nucleotide binding]; other site 321967002186 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 321967002187 active site 321967002188 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 321967002189 ApbE family; Region: ApbE; pfam02424 321967002190 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 321967002191 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 321967002192 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967002193 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967002194 Homeodomain-like domain; Region: HTH_32; pfam13565 321967002195 Integrase core domain; Region: rve; pfam00665 321967002196 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 321967002197 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 321967002198 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 321967002199 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 321967002200 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 321967002201 active site 321967002202 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 321967002203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967002204 S-adenosylmethionine binding site [chemical binding]; other site 321967002205 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 321967002206 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 321967002207 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 321967002208 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 321967002209 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 321967002210 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 321967002211 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 321967002212 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 321967002213 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 321967002214 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 321967002215 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 321967002216 classical (c) SDRs; Region: SDR_c; cd05233 321967002217 NAD(P) binding site [chemical binding]; other site 321967002218 active site 321967002219 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 321967002220 Helix-turn-helix domain; Region: HTH_25; pfam13413 321967002221 non-specific DNA binding site [nucleotide binding]; other site 321967002222 salt bridge; other site 321967002223 sequence-specific DNA binding site [nucleotide binding]; other site 321967002224 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 321967002225 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 321967002226 competence damage-inducible protein A; Provisional; Region: PRK00549 321967002227 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 321967002228 putative MPT binding site; other site 321967002229 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 321967002230 recombinase A; Provisional; Region: recA; PRK09354 321967002231 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 321967002232 hexamer interface [polypeptide binding]; other site 321967002233 Walker A motif; other site 321967002234 ATP binding site [chemical binding]; other site 321967002235 Walker B motif; other site 321967002236 ribonuclease Y; Region: RNase_Y; TIGR03319 321967002237 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 321967002238 Zn2+ binding site [ion binding]; other site 321967002239 Mg2+ binding site [ion binding]; other site 321967002240 Uncharacterized conserved protein [Function unknown]; Region: COG1739 321967002241 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 321967002242 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 321967002243 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 321967002244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 321967002245 ATP binding site [chemical binding]; other site 321967002246 putative Mg++ binding site [ion binding]; other site 321967002247 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 321967002248 nucleotide binding region [chemical binding]; other site 321967002249 ATP-binding site [chemical binding]; other site 321967002250 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 321967002251 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 321967002252 active site 321967002253 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 321967002254 30S subunit binding site; other site 321967002255 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 321967002256 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 321967002257 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 321967002258 nucleotide binding region [chemical binding]; other site 321967002259 ATP-binding site [chemical binding]; other site 321967002260 peptide chain release factor 2; Validated; Region: prfB; PRK00578 321967002261 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 321967002262 PCRF domain; Region: PCRF; pfam03462 321967002263 RF-1 domain; Region: RF-1; pfam00472 321967002264 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 321967002265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967002266 Walker A/P-loop; other site 321967002267 ATP binding site [chemical binding]; other site 321967002268 Q-loop/lid; other site 321967002269 ABC transporter signature motif; other site 321967002270 Walker B; other site 321967002271 D-loop; other site 321967002272 H-loop/switch region; other site 321967002273 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 321967002274 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 321967002275 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 321967002276 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 321967002277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 321967002278 active site 321967002279 phosphorylation site [posttranslational modification] 321967002280 intermolecular recognition site; other site 321967002281 dimerization interface [polypeptide binding]; other site 321967002282 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 321967002283 DNA binding site [nucleotide binding] 321967002284 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 321967002285 PAS domain; Region: PAS_8; pfam13188 321967002286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 321967002287 dimer interface [polypeptide binding]; other site 321967002288 phosphorylation site [posttranslational modification] 321967002289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 321967002290 ATP binding site [chemical binding]; other site 321967002291 Mg2+ binding site [ion binding]; other site 321967002292 G-X-G motif; other site 321967002293 phosphate binding protein; Region: ptsS_2; TIGR02136 321967002294 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 321967002295 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 321967002296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967002297 dimer interface [polypeptide binding]; other site 321967002298 conserved gate region; other site 321967002299 putative PBP binding loops; other site 321967002300 ABC-ATPase subunit interface; other site 321967002301 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 321967002302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967002303 dimer interface [polypeptide binding]; other site 321967002304 conserved gate region; other site 321967002305 putative PBP binding loops; other site 321967002306 ABC-ATPase subunit interface; other site 321967002307 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 321967002308 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 321967002309 Walker A/P-loop; other site 321967002310 ATP binding site [chemical binding]; other site 321967002311 Q-loop/lid; other site 321967002312 ABC transporter signature motif; other site 321967002313 Walker B; other site 321967002314 D-loop; other site 321967002315 H-loop/switch region; other site 321967002316 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14255 321967002317 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 321967002318 Walker A/P-loop; other site 321967002319 ATP binding site [chemical binding]; other site 321967002320 Q-loop/lid; other site 321967002321 ABC transporter signature motif; other site 321967002322 Walker B; other site 321967002323 D-loop; other site 321967002324 H-loop/switch region; other site 321967002325 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 321967002326 PhoU domain; Region: PhoU; pfam01895 321967002327 PhoU domain; Region: PhoU; pfam01895 321967002328 Uncharacterized conserved protein [Function unknown]; Region: COG3595 321967002329 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 321967002330 Membrane protein of unknown function; Region: DUF360; pfam04020 321967002331 HPr kinase/phosphorylase; Provisional; Region: PRK05428 321967002332 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 321967002333 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 321967002334 Hpr binding site; other site 321967002335 active site 321967002336 homohexamer subunit interaction site [polypeptide binding]; other site 321967002337 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 321967002338 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 321967002339 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 321967002340 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 321967002341 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 321967002342 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 321967002343 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 321967002344 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 321967002345 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 321967002346 active site 321967002347 substrate binding site [chemical binding]; other site 321967002348 metal binding site [ion binding]; metal-binding site 321967002349 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 321967002350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 321967002351 active site 321967002352 phosphorylation site [posttranslational modification] 321967002353 intermolecular recognition site; other site 321967002354 dimerization interface [polypeptide binding]; other site 321967002355 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 321967002356 DNA binding site [nucleotide binding] 321967002357 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 321967002358 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 321967002359 dimer interface [polypeptide binding]; other site 321967002360 phosphorylation site [posttranslational modification] 321967002361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 321967002362 ATP binding site [chemical binding]; other site 321967002363 Mg2+ binding site [ion binding]; other site 321967002364 G-X-G motif; other site 321967002365 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 321967002366 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 321967002367 Walker A/P-loop; other site 321967002368 ATP binding site [chemical binding]; other site 321967002369 Q-loop/lid; other site 321967002370 ABC transporter signature motif; other site 321967002371 Walker B; other site 321967002372 D-loop; other site 321967002373 H-loop/switch region; other site 321967002374 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 321967002375 FtsX-like permease family; Region: FtsX; pfam02687 321967002376 HD domain; Region: HD_3; cl17350 321967002377 excinuclease ABC subunit B; Provisional; Region: PRK05298 321967002378 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 321967002379 ATP binding site [chemical binding]; other site 321967002380 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 321967002381 nucleotide binding region [chemical binding]; other site 321967002382 ATP-binding site [chemical binding]; other site 321967002383 Ultra-violet resistance protein B; Region: UvrB; pfam12344 321967002384 UvrB/uvrC motif; Region: UVR; pfam02151 321967002385 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 321967002386 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 321967002387 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 321967002388 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 321967002389 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 321967002390 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 321967002391 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 321967002392 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 321967002393 phosphate binding site [ion binding]; other site 321967002394 putative substrate binding pocket [chemical binding]; other site 321967002395 dimer interface [polypeptide binding]; other site 321967002396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 321967002397 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 321967002398 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 321967002399 MarR family; Region: MarR; pfam01047 321967002400 Clp protease; Region: CLP_protease; pfam00574 321967002401 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 321967002402 oligomer interface [polypeptide binding]; other site 321967002403 active site residues [active] 321967002404 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 321967002405 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 321967002406 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 321967002407 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 321967002408 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 321967002409 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 321967002410 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 321967002411 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 321967002412 Phosphoglycerate kinase; Region: PGK; pfam00162 321967002413 substrate binding site [chemical binding]; other site 321967002414 hinge regions; other site 321967002415 ADP binding site [chemical binding]; other site 321967002416 catalytic site [active] 321967002417 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 321967002418 triosephosphate isomerase; Provisional; Region: PRK14567 321967002419 substrate binding site [chemical binding]; other site 321967002420 dimer interface [polypeptide binding]; other site 321967002421 catalytic triad [active] 321967002422 enolase; Provisional; Region: eno; PRK00077 321967002423 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 321967002424 dimer interface [polypeptide binding]; other site 321967002425 metal binding site [ion binding]; metal-binding site 321967002426 substrate binding pocket [chemical binding]; other site 321967002427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967002428 H+ Antiporter protein; Region: 2A0121; TIGR00900 321967002429 putative substrate translocation pore; other site 321967002430 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 321967002431 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 321967002432 Cl- selectivity filter; other site 321967002433 Cl- binding residues [ion binding]; other site 321967002434 pore gating glutamate residue; other site 321967002435 dimer interface [polypeptide binding]; other site 321967002436 H+/Cl- coupling transport residue; other site 321967002437 TrkA-C domain; Region: TrkA_C; pfam02080 321967002438 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 321967002439 Esterase/lipase [General function prediction only]; Region: COG1647 321967002440 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 321967002441 ribonuclease R; Region: RNase_R; TIGR02063 321967002442 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 321967002443 RNB domain; Region: RNB; pfam00773 321967002444 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 321967002445 RNA binding site [nucleotide binding]; other site 321967002446 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 321967002447 SmpB-tmRNA interface; other site 321967002448 Transposase domain (DUF772); Region: DUF772; pfam05598 321967002449 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 321967002450 Transcriptional regulators [Transcription]; Region: PurR; COG1609 321967002451 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 321967002452 DNA binding site [nucleotide binding] 321967002453 domain linker motif; other site 321967002454 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 321967002455 ligand binding site [chemical binding]; other site 321967002456 dimerization interface [polypeptide binding]; other site 321967002457 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 321967002458 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 321967002459 Ca binding site [ion binding]; other site 321967002460 active site 321967002461 catalytic site [active] 321967002462 maltose phosphorylase; Provisional; Region: PRK13807 321967002463 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 321967002464 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 321967002465 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 321967002466 beta-phosphoglucomutase; Region: bPGM; TIGR01990 321967002467 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967002468 motif II; other site 321967002469 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 321967002470 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967002471 non-specific DNA binding site [nucleotide binding]; other site 321967002472 salt bridge; other site 321967002473 sequence-specific DNA binding site [nucleotide binding]; other site 321967002474 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 321967002475 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 321967002476 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 321967002477 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 321967002478 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 321967002479 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 321967002480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967002481 dimer interface [polypeptide binding]; other site 321967002482 conserved gate region; other site 321967002483 putative PBP binding loops; other site 321967002484 ABC-ATPase subunit interface; other site 321967002485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967002486 dimer interface [polypeptide binding]; other site 321967002487 conserved gate region; other site 321967002488 putative PBP binding loops; other site 321967002489 ABC-ATPase subunit interface; other site 321967002490 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 321967002491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967002492 Walker A/P-loop; other site 321967002493 ATP binding site [chemical binding]; other site 321967002494 Q-loop/lid; other site 321967002495 ABC transporter signature motif; other site 321967002496 Walker B; other site 321967002497 D-loop; other site 321967002498 H-loop/switch region; other site 321967002499 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967002500 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 321967002501 Coenzyme A binding pocket [chemical binding]; other site 321967002502 Tubby C 2; Region: Tub_2; cl02043 321967002503 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967002504 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 321967002505 active site 321967002506 motif I; other site 321967002507 motif II; other site 321967002508 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 321967002509 ligand binding site [chemical binding]; other site 321967002510 active site 321967002511 UGI interface [polypeptide binding]; other site 321967002512 catalytic site [active] 321967002513 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 321967002514 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 321967002515 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 321967002516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967002517 Walker A/P-loop; other site 321967002518 ATP binding site [chemical binding]; other site 321967002519 Q-loop/lid; other site 321967002520 ABC transporter signature motif; other site 321967002521 Walker B; other site 321967002522 D-loop; other site 321967002523 H-loop/switch region; other site 321967002524 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 321967002525 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 321967002526 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 321967002527 active site 321967002528 catalytic site [active] 321967002529 substrate binding site [chemical binding]; other site 321967002530 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 321967002531 active site 321967002532 putative catalytic site [active] 321967002533 DNA binding site [nucleotide binding] 321967002534 putative phosphate binding site [ion binding]; other site 321967002535 metal binding site A [ion binding]; metal-binding site 321967002536 AP binding site [nucleotide binding]; other site 321967002537 metal binding site B [ion binding]; metal-binding site 321967002538 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 321967002539 FAD binding domain; Region: FAD_binding_4; pfam01565 321967002540 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 321967002541 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 321967002542 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 321967002543 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 321967002544 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967002545 non-specific DNA binding site [nucleotide binding]; other site 321967002546 salt bridge; other site 321967002547 sequence-specific DNA binding site [nucleotide binding]; other site 321967002548 Cupin domain; Region: Cupin_2; pfam07883 321967002549 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 321967002550 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 321967002551 Walker A/P-loop; other site 321967002552 ATP binding site [chemical binding]; other site 321967002553 Q-loop/lid; other site 321967002554 ABC transporter signature motif; other site 321967002555 Walker B; other site 321967002556 D-loop; other site 321967002557 H-loop/switch region; other site 321967002558 TOBE domain; Region: TOBE_2; pfam08402 321967002559 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 321967002560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967002561 dimer interface [polypeptide binding]; other site 321967002562 conserved gate region; other site 321967002563 putative PBP binding loops; other site 321967002564 ABC-ATPase subunit interface; other site 321967002565 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 321967002566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967002567 dimer interface [polypeptide binding]; other site 321967002568 conserved gate region; other site 321967002569 putative PBP binding loops; other site 321967002570 ABC-ATPase subunit interface; other site 321967002571 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 321967002572 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 321967002573 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 321967002574 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 321967002575 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 321967002576 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 321967002577 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967002578 motif II; other site 321967002579 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 321967002580 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 321967002581 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 321967002582 PXA domain; Region: PXA; cl02564 321967002583 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 321967002584 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 321967002585 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 321967002586 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 321967002587 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 321967002588 Walker A/P-loop; other site 321967002589 ATP binding site [chemical binding]; other site 321967002590 Q-loop/lid; other site 321967002591 ABC transporter signature motif; other site 321967002592 Walker B; other site 321967002593 D-loop; other site 321967002594 H-loop/switch region; other site 321967002595 Uncharacterized conserved protein [Function unknown]; Region: COG1624 321967002596 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 321967002597 YbbR-like protein; Region: YbbR; pfam07949 321967002598 YbbR-like protein; Region: YbbR; pfam07949 321967002599 YbbR-like protein; Region: YbbR; pfam07949 321967002600 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 321967002601 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 321967002602 active site 321967002603 substrate binding site [chemical binding]; other site 321967002604 metal binding site [ion binding]; metal-binding site 321967002605 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 321967002606 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 321967002607 glutaminase active site [active] 321967002608 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 321967002609 dimer interface [polypeptide binding]; other site 321967002610 active site 321967002611 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 321967002612 dimer interface [polypeptide binding]; other site 321967002613 active site 321967002614 hypothetical protein; Validated; Region: PRK00110 321967002615 Type II/IV secretion system protein; Region: T2SE; pfam00437 321967002616 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 321967002617 Walker A motif; other site 321967002618 ATP binding site [chemical binding]; other site 321967002619 Walker B motif; other site 321967002620 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 321967002621 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 321967002622 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 321967002623 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 321967002624 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 321967002625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967002626 S-adenosylmethionine binding site [chemical binding]; other site 321967002627 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 321967002628 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 321967002629 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 321967002630 putative acyl-acceptor binding pocket; other site 321967002631 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 321967002632 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 321967002633 Ligand binding site; other site 321967002634 metal-binding site 321967002635 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 321967002636 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 321967002637 Ligand binding site; other site 321967002638 metal-binding site 321967002639 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 321967002640 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 321967002641 putative acyl-acceptor binding pocket; other site 321967002642 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 321967002643 Melibiase; Region: Melibiase; pfam02065 321967002644 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 321967002645 SdpI/YhfL protein family; Region: SdpI; pfam13630 321967002646 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 321967002647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 321967002648 active site 321967002649 phosphorylation site [posttranslational modification] 321967002650 intermolecular recognition site; other site 321967002651 dimerization interface [polypeptide binding]; other site 321967002652 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 321967002653 DNA binding site [nucleotide binding] 321967002654 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 321967002655 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 321967002656 dimerization interface [polypeptide binding]; other site 321967002657 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 321967002658 dimer interface [polypeptide binding]; other site 321967002659 phosphorylation site [posttranslational modification] 321967002660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 321967002661 ATP binding site [chemical binding]; other site 321967002662 Mg2+ binding site [ion binding]; other site 321967002663 G-X-G motif; other site 321967002664 Predicted acetyltransferase [General function prediction only]; Region: COG3153 321967002665 Coenzyme A binding pocket [chemical binding]; other site 321967002666 hypothetical protein; Provisional; Region: PRK04435 321967002667 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 321967002668 DNA-binding interface [nucleotide binding]; DNA binding site 321967002669 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 321967002670 DNA polymerase IV; Reviewed; Region: PRK03103 321967002671 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 321967002672 active site 321967002673 DNA binding site [nucleotide binding] 321967002674 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 321967002675 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 321967002676 Double zinc ribbon; Region: DZR; pfam12773 321967002677 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 321967002678 active site 321967002679 catalytic triad [active] 321967002680 oxyanion hole [active] 321967002681 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 321967002682 Part of AAA domain; Region: AAA_19; pfam13245 321967002683 Family description; Region: UvrD_C_2; pfam13538 321967002684 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 321967002685 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 321967002686 nucleotide binding pocket [chemical binding]; other site 321967002687 K-X-D-G motif; other site 321967002688 catalytic site [active] 321967002689 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 321967002690 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 321967002691 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 321967002692 Dimer interface [polypeptide binding]; other site 321967002693 BRCT sequence motif; other site 321967002694 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 321967002695 putative dimer interface [polypeptide binding]; other site 321967002696 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 321967002697 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 321967002698 putative dimer interface [polypeptide binding]; other site 321967002699 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 321967002700 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 321967002701 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 321967002702 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 321967002703 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 321967002704 GatB domain; Region: GatB_Yqey; smart00845 321967002705 putative lipid kinase; Reviewed; Region: PRK13055 321967002706 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 321967002707 TRAM domain; Region: TRAM; pfam01938 321967002708 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 321967002709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967002710 S-adenosylmethionine binding site [chemical binding]; other site 321967002711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967002712 Major Facilitator Superfamily; Region: MFS_1; pfam07690 321967002713 putative substrate translocation pore; other site 321967002714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967002715 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 321967002716 active site 321967002717 motif I; other site 321967002718 motif II; other site 321967002719 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 321967002720 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 321967002721 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 321967002722 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 321967002723 active site 321967002724 Zn binding site [ion binding]; other site 321967002725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967002726 Major Facilitator Superfamily; Region: MFS_1; pfam07690 321967002727 putative substrate translocation pore; other site 321967002728 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967002729 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 321967002730 Coenzyme A binding pocket [chemical binding]; other site 321967002731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 321967002732 Homeodomain-like domain; Region: HTH_23; pfam13384 321967002733 Transposase; Region: DDE_Tnp_ISL3; pfam01610 321967002734 EDD domain protein, DegV family; Region: DegV; TIGR00762 321967002735 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 321967002736 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 321967002737 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 321967002738 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 321967002739 active site 321967002740 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 321967002741 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 321967002742 formate dehydrogenase; Provisional; Region: PRK07574 321967002743 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 321967002744 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 321967002745 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 321967002746 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 321967002747 ATP binding site [chemical binding]; other site 321967002748 putative Mg++ binding site [ion binding]; other site 321967002749 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 321967002750 nucleotide binding region [chemical binding]; other site 321967002751 ATP-binding site [chemical binding]; other site 321967002752 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 321967002753 active site 321967002754 methionine cluster; other site 321967002755 phosphorylation site [posttranslational modification] 321967002756 metal binding site [ion binding]; metal-binding site 321967002757 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 321967002758 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 321967002759 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 321967002760 ATP binding site [chemical binding]; other site 321967002761 putative Mg++ binding site [ion binding]; other site 321967002762 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 321967002763 nucleotide binding region [chemical binding]; other site 321967002764 ATP-binding site [chemical binding]; other site 321967002765 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 321967002766 HRDC domain; Region: HRDC; pfam00570 321967002767 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 321967002768 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 321967002769 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 321967002770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 321967002771 WHG domain; Region: WHG; pfam13305 321967002772 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 321967002773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 321967002774 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 321967002775 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 321967002776 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 321967002777 active site 321967002778 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 321967002779 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 321967002780 active site 321967002781 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 321967002782 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 321967002783 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 321967002784 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 321967002785 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 321967002786 active site 321967002787 tetramer interface; other site 321967002788 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 321967002789 active site 321967002790 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 321967002791 substrate binding site; other site 321967002792 dimer interface; other site 321967002793 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 321967002794 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 321967002795 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 321967002796 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 321967002797 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 321967002798 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 321967002799 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 321967002800 Homeodomain-like domain; Region: HTH_23; pfam13384 321967002801 Transposase; Region: DDE_Tnp_ISL3; pfam01610 321967002802 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 321967002803 beta-galactosidase; Region: BGL; TIGR03356 321967002804 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 321967002805 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 321967002806 active site turn [active] 321967002807 phosphorylation site [posttranslational modification] 321967002808 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 321967002809 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 321967002810 HPr interaction site; other site 321967002811 glycerol kinase (GK) interaction site [polypeptide binding]; other site 321967002812 active site 321967002813 phosphorylation site [posttranslational modification] 321967002814 transcriptional antiterminator BglG; Provisional; Region: PRK09772 321967002815 CAT RNA binding domain; Region: CAT_RBD; smart01061 321967002816 PRD domain; Region: PRD; pfam00874 321967002817 PRD domain; Region: PRD; pfam00874 321967002818 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 321967002819 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 321967002820 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 321967002821 Ligand binding site; other site 321967002822 Putative Catalytic site; other site 321967002823 DXD motif; other site 321967002824 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 321967002825 Predicted membrane protein [Function unknown]; Region: COG4129 321967002826 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 321967002827 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 321967002828 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 321967002829 DNA-binding site [nucleotide binding]; DNA binding site 321967002830 RNA-binding motif; other site 321967002831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 321967002832 Coenzyme A binding pocket [chemical binding]; other site 321967002833 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 321967002834 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 321967002835 active site 321967002836 xanthine permease; Region: pbuX; TIGR03173 321967002837 ATP-grasp domain; Region: ATP-grasp_4; cl17255 321967002838 adenylosuccinate lyase; Provisional; Region: PRK07492 321967002839 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 321967002840 tetramer interface [polypeptide binding]; other site 321967002841 active site 321967002842 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 321967002843 Sulfatase; Region: Sulfatase; pfam00884 321967002844 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 321967002845 Sugar transport protein; Region: Sugar_transport; pfam06800 321967002846 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 321967002847 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 321967002848 active site 321967002849 dimer interface [polypeptide binding]; other site 321967002850 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 321967002851 dimer interface [polypeptide binding]; other site 321967002852 active site 321967002853 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 321967002854 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 321967002855 Uncharacterized conserved protein [Function unknown]; Region: COG1359 321967002856 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 321967002857 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 321967002858 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967002859 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967002860 Integrase core domain; Region: rve; pfam00665 321967002861 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 321967002862 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 321967002863 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 321967002864 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 321967002865 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 321967002866 nucleoside/Zn binding site; other site 321967002867 dimer interface [polypeptide binding]; other site 321967002868 catalytic motif [active] 321967002869 TspO/MBR family; Region: TspO_MBR; pfam03073 321967002870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967002871 Major Facilitator Superfamily; Region: MFS_1; pfam07690 321967002872 putative substrate translocation pore; other site 321967002873 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 321967002874 Peptidase family C69; Region: Peptidase_C69; pfam03577 321967002875 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 321967002876 catalytic core [active] 321967002877 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 321967002878 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 321967002879 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 321967002880 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 321967002881 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 321967002882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967002883 Walker A/P-loop; other site 321967002884 ATP binding site [chemical binding]; other site 321967002885 Q-loop/lid; other site 321967002886 ABC transporter signature motif; other site 321967002887 Walker B; other site 321967002888 D-loop; other site 321967002889 H-loop/switch region; other site 321967002890 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 321967002891 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 321967002892 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 321967002893 Walker A/P-loop; other site 321967002894 ATP binding site [chemical binding]; other site 321967002895 Q-loop/lid; other site 321967002896 ABC transporter signature motif; other site 321967002897 Walker B; other site 321967002898 D-loop; other site 321967002899 H-loop/switch region; other site 321967002900 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 321967002901 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 321967002902 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 321967002903 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 321967002904 putative metal binding site [ion binding]; other site 321967002905 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 321967002906 active site 321967002907 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 321967002908 Beta-lactamase; Region: Beta-lactamase; pfam00144 321967002909 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 321967002910 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 321967002911 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 321967002912 peptide chain release factor 1; Validated; Region: prfA; PRK00591 321967002913 This domain is found in peptide chain release factors; Region: PCRF; smart00937 321967002914 RF-1 domain; Region: RF-1; pfam00472 321967002915 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 321967002916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967002917 S-adenosylmethionine binding site [chemical binding]; other site 321967002918 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 321967002919 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 321967002920 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 321967002921 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 321967002922 dimer interface [polypeptide binding]; other site 321967002923 active site 321967002924 glycine-pyridoxal phosphate binding site [chemical binding]; other site 321967002925 folate binding site [chemical binding]; other site 321967002926 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 321967002927 active site 321967002928 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 321967002929 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 321967002930 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 321967002931 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 321967002932 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 321967002933 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 321967002934 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 321967002935 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 321967002936 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 321967002937 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 321967002938 beta subunit interaction interface [polypeptide binding]; other site 321967002939 Walker A motif; other site 321967002940 ATP binding site [chemical binding]; other site 321967002941 Walker B motif; other site 321967002942 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 321967002943 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 321967002944 core domain interface [polypeptide binding]; other site 321967002945 delta subunit interface [polypeptide binding]; other site 321967002946 epsilon subunit interface [polypeptide binding]; other site 321967002947 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 321967002948 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 321967002949 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 321967002950 alpha subunit interaction interface [polypeptide binding]; other site 321967002951 Walker A motif; other site 321967002952 ATP binding site [chemical binding]; other site 321967002953 Walker B motif; other site 321967002954 inhibitor binding site; inhibition site 321967002955 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 321967002956 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 321967002957 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 321967002958 gamma subunit interface [polypeptide binding]; other site 321967002959 epsilon subunit interface [polypeptide binding]; other site 321967002960 LBP interface [polypeptide binding]; other site 321967002961 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 321967002962 rod shape-determining protein MreB; Provisional; Region: PRK13930 321967002963 MreB and similar proteins; Region: MreB_like; cd10225 321967002964 nucleotide binding site [chemical binding]; other site 321967002965 Mg binding site [ion binding]; other site 321967002966 putative protofilament interaction site [polypeptide binding]; other site 321967002967 RodZ interaction site [polypeptide binding]; other site 321967002968 Haemolytic domain; Region: Haemolytic; cl00506 321967002969 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 321967002970 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 321967002971 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 321967002972 lipoyl attachment site [posttranslational modification]; other site 321967002973 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 321967002974 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 321967002975 metal binding site [ion binding]; metal-binding site 321967002976 dimer interface [polypeptide binding]; other site 321967002977 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 321967002978 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 321967002979 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 321967002980 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 321967002981 Walker A/P-loop; other site 321967002982 ATP binding site [chemical binding]; other site 321967002983 Q-loop/lid; other site 321967002984 ABC transporter signature motif; other site 321967002985 Walker B; other site 321967002986 D-loop; other site 321967002987 H-loop/switch region; other site 321967002988 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 321967002989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967002990 dimer interface [polypeptide binding]; other site 321967002991 conserved gate region; other site 321967002992 ABC-ATPase subunit interface; other site 321967002993 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 321967002994 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 321967002995 Walker A/P-loop; other site 321967002996 ATP binding site [chemical binding]; other site 321967002997 Q-loop/lid; other site 321967002998 ABC transporter signature motif; other site 321967002999 Walker B; other site 321967003000 D-loop; other site 321967003001 H-loop/switch region; other site 321967003002 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 321967003003 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 321967003004 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 321967003005 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 321967003006 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 321967003007 catalytic residue [active] 321967003008 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 321967003009 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 321967003010 trimerization site [polypeptide binding]; other site 321967003011 active site 321967003012 FeS assembly protein SufB; Region: sufB; TIGR01980 321967003013 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 321967003014 Transposase domain (DUF772); Region: DUF772; pfam05598 321967003015 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 321967003016 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 321967003017 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 321967003018 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967003019 active site 321967003020 motif I; other site 321967003021 motif II; other site 321967003022 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 321967003023 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967003024 non-specific DNA binding site [nucleotide binding]; other site 321967003025 salt bridge; other site 321967003026 sequence-specific DNA binding site [nucleotide binding]; other site 321967003027 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 321967003028 Ligand Binding Site [chemical binding]; other site 321967003029 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967003030 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967003031 Integrase core domain; Region: rve; pfam00665 321967003032 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 321967003033 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 321967003034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 321967003035 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 321967003036 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 321967003037 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 321967003038 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 321967003039 putative L-serine binding site [chemical binding]; other site 321967003040 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 321967003041 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 321967003042 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 321967003043 catalytic core [active] 321967003044 methionine sulfoxide reductase A; Provisional; Region: PRK14054 321967003045 short chain dehydrogenase; Provisional; Region: PRK06197 321967003046 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 321967003047 putative NAD(P) binding site [chemical binding]; other site 321967003048 active site 321967003049 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 321967003050 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 321967003051 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 321967003052 active site 321967003053 hypothetical protein; Provisional; Region: PRK07329 321967003054 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 321967003055 active site 321967003056 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 321967003057 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 321967003058 peptide binding site [polypeptide binding]; other site 321967003059 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 321967003060 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 321967003061 dimer interface [polypeptide binding]; other site 321967003062 phosphorylation site [posttranslational modification] 321967003063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 321967003064 ATP binding site [chemical binding]; other site 321967003065 Mg2+ binding site [ion binding]; other site 321967003066 G-X-G motif; other site 321967003067 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 321967003068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 321967003069 active site 321967003070 phosphorylation site [posttranslational modification] 321967003071 intermolecular recognition site; other site 321967003072 dimerization interface [polypeptide binding]; other site 321967003073 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 321967003074 DNA binding site [nucleotide binding] 321967003075 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 321967003076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967003077 Walker A/P-loop; other site 321967003078 ATP binding site [chemical binding]; other site 321967003079 Q-loop/lid; other site 321967003080 ABC transporter signature motif; other site 321967003081 Walker B; other site 321967003082 D-loop; other site 321967003083 H-loop/switch region; other site 321967003084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 321967003085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 321967003086 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 321967003087 dimerization interface [polypeptide binding]; other site 321967003088 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 321967003089 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 321967003090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 321967003091 NADH(P)-binding; Region: NAD_binding_10; pfam13460 321967003092 NAD(P) binding site [chemical binding]; other site 321967003093 active site 321967003094 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967003095 Coenzyme A binding pocket [chemical binding]; other site 321967003096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967003097 Coenzyme A binding pocket [chemical binding]; other site 321967003098 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967003099 Integrase core domain; Region: rve; pfam00665 321967003100 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 321967003101 EDD domain protein, DegV family; Region: DegV; TIGR00762 321967003102 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 321967003103 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 321967003104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 321967003105 active site 321967003106 phosphorylation site [posttranslational modification] 321967003107 intermolecular recognition site; other site 321967003108 dimerization interface [polypeptide binding]; other site 321967003109 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 321967003110 DNA binding residues [nucleotide binding] 321967003111 dimerization interface [polypeptide binding]; other site 321967003112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 321967003113 Histidine kinase; Region: HisKA_3; pfam07730 321967003114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 321967003115 ATP binding site [chemical binding]; other site 321967003116 Mg2+ binding site [ion binding]; other site 321967003117 G-X-G motif; other site 321967003118 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 321967003119 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 321967003120 Walker A/P-loop; other site 321967003121 ATP binding site [chemical binding]; other site 321967003122 Q-loop/lid; other site 321967003123 ABC transporter signature motif; other site 321967003124 Walker B; other site 321967003125 D-loop; other site 321967003126 H-loop/switch region; other site 321967003127 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 321967003128 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 321967003129 DNA binding residues [nucleotide binding] 321967003130 dimer interface [polypeptide binding]; other site 321967003131 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 321967003132 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 321967003133 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 321967003134 Transposase domain (DUF772); Region: DUF772; pfam05598 321967003135 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 321967003136 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 321967003137 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 321967003138 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 321967003139 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 321967003140 RNA binding site [nucleotide binding]; other site 321967003141 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 321967003142 Transposase; Region: HTH_Tnp_1; pfam01527 321967003143 putative transposase OrfB; Reviewed; Region: PHA02517 321967003144 HTH-like domain; Region: HTH_21; pfam13276 321967003145 Integrase core domain; Region: rve; pfam00665 321967003146 Integrase core domain; Region: rve_3; pfam13683 321967003147 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 321967003148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967003149 non-specific DNA binding site [nucleotide binding]; other site 321967003150 salt bridge; other site 321967003151 sequence-specific DNA binding site [nucleotide binding]; other site 321967003152 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 321967003153 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 321967003154 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 321967003155 RNA binding surface [nucleotide binding]; other site 321967003156 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 321967003157 GAF domain; Region: GAF_2; pfam13185 321967003158 septation ring formation regulator EzrA; Provisional; Region: PRK04778 321967003159 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 321967003160 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 321967003161 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 321967003162 Ligand Binding Site [chemical binding]; other site 321967003163 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 321967003164 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 321967003165 CoA binding domain; Region: CoA_binding; pfam02629 321967003166 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 321967003167 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 321967003168 active site 321967003169 HIGH motif; other site 321967003170 nucleotide binding site [chemical binding]; other site 321967003171 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 321967003172 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 321967003173 active site 321967003174 KMSKS motif; other site 321967003175 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 321967003176 tRNA binding surface [nucleotide binding]; other site 321967003177 anticodon binding site; other site 321967003178 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 321967003179 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 321967003180 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 321967003181 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 321967003182 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967003183 motif II; other site 321967003184 hypothetical protein; Reviewed; Region: PRK00024 321967003185 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 321967003186 MPN+ (JAMM) motif; other site 321967003187 Zinc-binding site [ion binding]; other site 321967003188 rod shape-determining protein MreB; Provisional; Region: PRK13927 321967003189 MreB and similar proteins; Region: MreB_like; cd10225 321967003190 nucleotide binding site [chemical binding]; other site 321967003191 Mg binding site [ion binding]; other site 321967003192 putative protofilament interaction site [polypeptide binding]; other site 321967003193 RodZ interaction site [polypeptide binding]; other site 321967003194 rod shape-determining protein MreC; Provisional; Region: PRK13922 321967003195 rod shape-determining protein MreC; Region: MreC; pfam04085 321967003196 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 321967003197 septum formation inhibitor; Reviewed; Region: minC; PRK00513 321967003198 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 321967003199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967003200 dimer interface [polypeptide binding]; other site 321967003201 conserved gate region; other site 321967003202 putative PBP binding loops; other site 321967003203 ABC-ATPase subunit interface; other site 321967003204 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 321967003205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967003206 Walker A/P-loop; other site 321967003207 ATP binding site [chemical binding]; other site 321967003208 Q-loop/lid; other site 321967003209 ABC transporter signature motif; other site 321967003210 Walker B; other site 321967003211 D-loop; other site 321967003212 H-loop/switch region; other site 321967003213 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 321967003214 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 321967003215 substrate binding pocket [chemical binding]; other site 321967003216 membrane-bound complex binding site; other site 321967003217 hinge residues; other site 321967003218 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 321967003219 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 321967003220 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 321967003221 putative active site [active] 321967003222 catalytic site [active] 321967003223 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 321967003224 putative active site [active] 321967003225 catalytic site [active] 321967003226 cell division protein MraZ; Reviewed; Region: PRK00326 321967003227 MraZ protein; Region: MraZ; pfam02381 321967003228 MraZ protein; Region: MraZ; pfam02381 321967003229 MraW methylase family; Region: Methyltransf_5; pfam01795 321967003230 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 321967003231 Cell division protein FtsL; Region: FtsL; cl11433 321967003232 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 321967003233 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 321967003234 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 321967003235 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 321967003236 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 321967003237 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 321967003238 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 321967003239 Mg++ binding site [ion binding]; other site 321967003240 putative catalytic motif [active] 321967003241 putative substrate binding site [chemical binding]; other site 321967003242 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 321967003243 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 321967003244 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 321967003245 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 321967003246 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 321967003247 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 321967003248 active site 321967003249 homodimer interface [polypeptide binding]; other site 321967003250 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 321967003251 Cell division protein FtsQ; Region: FtsQ; pfam03799 321967003252 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 321967003253 Cell division protein FtsA; Region: FtsA; smart00842 321967003254 Cell division protein FtsA; Region: FtsA; pfam14450 321967003255 cell division protein FtsZ; Validated; Region: PRK09330 321967003256 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 321967003257 nucleotide binding site [chemical binding]; other site 321967003258 SulA interaction site; other site 321967003259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 321967003260 YGGT family; Region: YGGT; pfam02325 321967003261 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 321967003262 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 321967003263 RNA binding surface [nucleotide binding]; other site 321967003264 DivIVA protein; Region: DivIVA; pfam05103 321967003265 DivIVA domain; Region: DivI1A_domain; TIGR03544 321967003266 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 321967003267 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 321967003268 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 321967003269 active site 321967003270 HIGH motif; other site 321967003271 nucleotide binding site [chemical binding]; other site 321967003272 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 321967003273 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 321967003274 active site 321967003275 KMSKS motif; other site 321967003276 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 321967003277 tRNA binding surface [nucleotide binding]; other site 321967003278 anticodon binding site; other site 321967003279 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 321967003280 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 321967003281 DNA-binding site [nucleotide binding]; DNA binding site 321967003282 RNA-binding motif; other site 321967003283 PBP superfamily domain; Region: PBP_like_2; cl17296 321967003284 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 321967003285 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 321967003286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967003287 putative substrate translocation pore; other site 321967003288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967003289 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 321967003290 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 321967003291 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 321967003292 dimer interface [polypeptide binding]; other site 321967003293 ADP-ribose binding site [chemical binding]; other site 321967003294 active site 321967003295 nudix motif; other site 321967003296 metal binding site [ion binding]; metal-binding site 321967003297 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 321967003298 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 321967003299 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 321967003300 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 321967003301 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 321967003302 catalytic residue [active] 321967003303 Putative amino acid metabolism; Region: DUF1831; pfam08866 321967003304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967003305 Walker A/P-loop; other site 321967003306 ATP binding site [chemical binding]; other site 321967003307 Q-loop/lid; other site 321967003308 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967003309 ABC transporter signature motif; other site 321967003310 Walker B; other site 321967003311 D-loop; other site 321967003312 H-loop/switch region; other site 321967003313 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967003314 AAA domain; Region: AAA_21; pfam13304 321967003315 Walker A/P-loop; other site 321967003316 ATP binding site [chemical binding]; other site 321967003317 Q-loop/lid; other site 321967003318 ABC transporter signature motif; other site 321967003319 Walker B; other site 321967003320 D-loop; other site 321967003321 H-loop/switch region; other site 321967003322 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 321967003323 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 321967003324 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 321967003325 catalytic core [active] 321967003326 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 321967003327 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 321967003328 AAA domain; Region: AAA_30; pfam13604 321967003329 Family description; Region: UvrD_C_2; pfam13538 321967003330 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 321967003331 Sterol carrier protein domain; Region: SCP2_2; pfam13530 321967003332 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 321967003333 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 321967003334 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 321967003335 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 321967003336 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 321967003337 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 321967003338 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 321967003339 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 321967003340 active site 321967003341 catalytic residues [active] 321967003342 metal binding site [ion binding]; metal-binding site 321967003343 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 321967003344 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 321967003345 TPP-binding site [chemical binding]; other site 321967003346 tetramer interface [polypeptide binding]; other site 321967003347 heterodimer interface [polypeptide binding]; other site 321967003348 phosphorylation loop region [posttranslational modification] 321967003349 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 321967003350 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 321967003351 alpha subunit interface [polypeptide binding]; other site 321967003352 TPP binding site [chemical binding]; other site 321967003353 heterodimer interface [polypeptide binding]; other site 321967003354 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 321967003355 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 321967003356 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 321967003357 E3 interaction surface; other site 321967003358 lipoyl attachment site [posttranslational modification]; other site 321967003359 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 321967003360 E3 interaction surface; other site 321967003361 lipoyl attachment site [posttranslational modification]; other site 321967003362 e3 binding domain; Region: E3_binding; pfam02817 321967003363 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 321967003364 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 321967003365 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 321967003366 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 321967003367 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 321967003368 Winged helix-turn helix; Region: HTH_29; pfam13551 321967003369 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 321967003370 DNA-binding interface [nucleotide binding]; DNA binding site 321967003371 putative transposase OrfB; Reviewed; Region: PHA02517 321967003372 HTH-like domain; Region: HTH_21; pfam13276 321967003373 Integrase core domain; Region: rve; pfam00665 321967003374 Integrase core domain; Region: rve_2; pfam13333 321967003375 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 321967003376 NAD(P) binding site [chemical binding]; other site 321967003377 substrate binding site [chemical binding]; other site 321967003378 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 321967003379 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 321967003380 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 321967003381 active site 321967003382 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 321967003383 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 321967003384 G1 box; other site 321967003385 putative GEF interaction site [polypeptide binding]; other site 321967003386 GTP/Mg2+ binding site [chemical binding]; other site 321967003387 Switch I region; other site 321967003388 G2 box; other site 321967003389 G3 box; other site 321967003390 Switch II region; other site 321967003391 G4 box; other site 321967003392 G5 box; other site 321967003393 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 321967003394 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 321967003395 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 321967003396 pyruvate carboxylase; Reviewed; Region: PRK12999 321967003397 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 321967003398 ATP-grasp domain; Region: ATP-grasp_4; cl17255 321967003399 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 321967003400 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 321967003401 active site 321967003402 catalytic residues [active] 321967003403 metal binding site [ion binding]; metal-binding site 321967003404 homodimer binding site [polypeptide binding]; other site 321967003405 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 321967003406 carboxyltransferase (CT) interaction site; other site 321967003407 biotinylation site [posttranslational modification]; other site 321967003408 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 321967003409 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 321967003410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967003411 S-adenosylmethionine binding site [chemical binding]; other site 321967003412 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 321967003413 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 321967003414 active site 321967003415 (T/H)XGH motif; other site 321967003416 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 321967003417 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 321967003418 protein binding site [polypeptide binding]; other site 321967003419 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 321967003420 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 321967003421 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 321967003422 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 321967003423 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 321967003424 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 321967003425 SLBB domain; Region: SLBB; pfam10531 321967003426 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 321967003427 Helix-hairpin-helix motif; Region: HHH; pfam00633 321967003428 Competence protein; Region: Competence; pfam03772 321967003429 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 321967003430 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 321967003431 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 321967003432 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 321967003433 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 321967003434 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 321967003435 16S/18S rRNA binding site [nucleotide binding]; other site 321967003436 S13e-L30e interaction site [polypeptide binding]; other site 321967003437 25S rRNA binding site [nucleotide binding]; other site 321967003438 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 321967003439 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 321967003440 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 321967003441 elongation factor Tu; Reviewed; Region: PRK00049 321967003442 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 321967003443 G1 box; other site 321967003444 GEF interaction site [polypeptide binding]; other site 321967003445 GTP/Mg2+ binding site [chemical binding]; other site 321967003446 Switch I region; other site 321967003447 G2 box; other site 321967003448 G3 box; other site 321967003449 Switch II region; other site 321967003450 G4 box; other site 321967003451 G5 box; other site 321967003452 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 321967003453 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 321967003454 Antibiotic Binding Site [chemical binding]; other site 321967003455 Homeodomain-like domain; Region: HTH_23; cl17451 321967003456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 321967003457 Transposase; Region: DDE_Tnp_ISL3; pfam01610 321967003458 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967003459 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967003460 Integrase core domain; Region: rve; pfam00665 321967003461 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 321967003462 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967003463 Walker A/P-loop; other site 321967003464 ATP binding site [chemical binding]; other site 321967003465 Q-loop/lid; other site 321967003466 ABC transporter signature motif; other site 321967003467 Walker B; other site 321967003468 D-loop; other site 321967003469 H-loop/switch region; other site 321967003470 trigger factor; Provisional; Region: tig; PRK01490 321967003471 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 321967003472 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 321967003473 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 321967003474 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 321967003475 G1 box; other site 321967003476 GTP/Mg2+ binding site [chemical binding]; other site 321967003477 Switch I region; other site 321967003478 G2 box; other site 321967003479 G3 box; other site 321967003480 Switch II region; other site 321967003481 G4 box; other site 321967003482 G5 box; other site 321967003483 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 321967003484 putative metal binding site [ion binding]; other site 321967003485 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 321967003486 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 321967003487 substrate binding pocket [chemical binding]; other site 321967003488 membrane-bound complex binding site; other site 321967003489 hinge residues; other site 321967003490 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 321967003491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967003492 dimer interface [polypeptide binding]; other site 321967003493 conserved gate region; other site 321967003494 putative PBP binding loops; other site 321967003495 ABC-ATPase subunit interface; other site 321967003496 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 321967003497 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 321967003498 Walker A/P-loop; other site 321967003499 ATP binding site [chemical binding]; other site 321967003500 Q-loop/lid; other site 321967003501 ABC transporter signature motif; other site 321967003502 Walker B; other site 321967003503 D-loop; other site 321967003504 H-loop/switch region; other site 321967003505 Pleckstrin homology-like domain; Region: PH-like; cl17171 321967003506 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 321967003507 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 321967003508 GIY-YIG motif/motif A; other site 321967003509 active site 321967003510 catalytic site [active] 321967003511 putative DNA binding site [nucleotide binding]; other site 321967003512 metal binding site [ion binding]; metal-binding site 321967003513 UvrB/uvrC motif; Region: UVR; pfam02151 321967003514 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 321967003515 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 321967003516 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 321967003517 active site 321967003518 phosphorylation site [posttranslational modification] 321967003519 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 321967003520 active site 321967003521 P-loop; other site 321967003522 phosphorylation site [posttranslational modification] 321967003523 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 321967003524 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 321967003525 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 321967003526 putative substrate binding site [chemical binding]; other site 321967003527 putative ATP binding site [chemical binding]; other site 321967003528 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 321967003529 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 321967003530 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 321967003531 GTPase CgtA; Reviewed; Region: obgE; PRK12297 321967003532 GTP1/OBG; Region: GTP1_OBG; pfam01018 321967003533 Obg GTPase; Region: Obg; cd01898 321967003534 G1 box; other site 321967003535 GTP/Mg2+ binding site [chemical binding]; other site 321967003536 Switch I region; other site 321967003537 G2 box; other site 321967003538 G3 box; other site 321967003539 Switch II region; other site 321967003540 G4 box; other site 321967003541 G5 box; other site 321967003542 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 321967003543 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 321967003544 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 321967003545 catalytic triad [active] 321967003546 catalytic triad [active] 321967003547 oxyanion hole [active] 321967003548 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 321967003549 Putative transposase; Region: Y2_Tnp; pfam04986 321967003550 ribonuclease Z; Region: RNase_Z; TIGR02651 321967003551 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 321967003552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 321967003553 NAD(P) binding site [chemical binding]; other site 321967003554 active site 321967003555 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 321967003556 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 321967003557 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 321967003558 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 321967003559 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 321967003560 active site 321967003561 metal binding site [ion binding]; metal-binding site 321967003562 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 321967003563 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 321967003564 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 321967003565 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 321967003566 active site 321967003567 PHP Thumb interface [polypeptide binding]; other site 321967003568 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 321967003569 generic binding surface I; other site 321967003570 generic binding surface II; other site 321967003571 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 321967003572 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 321967003573 active site 321967003574 ADP/pyrophosphate binding site [chemical binding]; other site 321967003575 dimerization interface [polypeptide binding]; other site 321967003576 allosteric effector site; other site 321967003577 fructose-1,6-bisphosphate binding site; other site 321967003578 pyruvate kinase; Provisional; Region: PRK06354 321967003579 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 321967003580 domain interfaces; other site 321967003581 active site 321967003582 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 321967003583 Protein of unknown function (DUF441); Region: DUF441; pfam04284 321967003584 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 321967003585 S1 domain; Region: S1_2; pfam13509 321967003586 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 321967003587 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 321967003588 active site 321967003589 Int/Topo IB signature motif; other site 321967003590 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 321967003591 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 321967003592 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 321967003593 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 321967003594 RNA binding surface [nucleotide binding]; other site 321967003595 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 321967003596 active site 321967003597 Predicted membrane protein [Function unknown]; Region: COG3601 321967003598 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 321967003599 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 321967003600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 321967003601 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 321967003602 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 321967003603 ATP binding site [chemical binding]; other site 321967003604 putative Mg++ binding site [ion binding]; other site 321967003605 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 321967003606 nucleotide binding region [chemical binding]; other site 321967003607 ATP-binding site [chemical binding]; other site 321967003608 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 321967003609 cytidylate kinase; Provisional; Region: cmk; PRK00023 321967003610 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 321967003611 CMP-binding site; other site 321967003612 The sites determining sugar specificity; other site 321967003613 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 321967003614 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 321967003615 RNA binding site [nucleotide binding]; other site 321967003616 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 321967003617 RNA binding site [nucleotide binding]; other site 321967003618 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 321967003619 RNA binding site [nucleotide binding]; other site 321967003620 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 321967003621 RNA binding site [nucleotide binding]; other site 321967003622 GTP-binding protein Der; Reviewed; Region: PRK00093 321967003623 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 321967003624 G1 box; other site 321967003625 GTP/Mg2+ binding site [chemical binding]; other site 321967003626 Switch I region; other site 321967003627 G2 box; other site 321967003628 Switch II region; other site 321967003629 G3 box; other site 321967003630 G4 box; other site 321967003631 G5 box; other site 321967003632 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 321967003633 G1 box; other site 321967003634 GTP/Mg2+ binding site [chemical binding]; other site 321967003635 Switch I region; other site 321967003636 G2 box; other site 321967003637 G3 box; other site 321967003638 Switch II region; other site 321967003639 G4 box; other site 321967003640 G5 box; other site 321967003641 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 321967003642 IHF dimer interface [polypeptide binding]; other site 321967003643 IHF - DNA interface [nucleotide binding]; other site 321967003644 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 321967003645 TPR motif; other site 321967003646 binding surface 321967003647 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 321967003648 binding surface 321967003649 TPR motif; other site 321967003650 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 321967003651 binding surface 321967003652 TPR motif; other site 321967003653 TPR repeat; Region: TPR_11; pfam13414 321967003654 Uncharacterized conserved protein [Function unknown]; Region: COG1284 321967003655 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 321967003656 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 321967003657 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 321967003658 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 321967003659 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 321967003660 active site 321967003661 NTP binding site [chemical binding]; other site 321967003662 metal binding triad [ion binding]; metal-binding site 321967003663 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 321967003664 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 321967003665 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 321967003666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967003667 Walker A/P-loop; other site 321967003668 ATP binding site [chemical binding]; other site 321967003669 Q-loop/lid; other site 321967003670 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 321967003671 ABC transporter signature motif; other site 321967003672 Walker B; other site 321967003673 D-loop; other site 321967003674 ABC transporter; Region: ABC_tran_2; pfam12848 321967003675 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 321967003676 thymidylate synthase; Region: thym_sym; TIGR03284 321967003677 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 321967003678 dimerization interface [polypeptide binding]; other site 321967003679 active site 321967003680 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 321967003681 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 321967003682 folate binding site [chemical binding]; other site 321967003683 NADP+ binding site [chemical binding]; other site 321967003684 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 321967003685 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 321967003686 EDD domain protein, DegV family; Region: DegV; TIGR00762 321967003687 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 321967003688 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 321967003689 active site 321967003690 catalytic triad [active] 321967003691 oxyanion hole [active] 321967003692 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 321967003693 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 321967003694 hypothetical protein; Provisional; Region: PRK13672 321967003695 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 321967003696 C-terminal peptidase (prc); Region: prc; TIGR00225 321967003697 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 321967003698 protein binding site [polypeptide binding]; other site 321967003699 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 321967003700 Catalytic dyad [active] 321967003701 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 321967003702 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 321967003703 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 321967003704 GTP/Mg2+ binding site [chemical binding]; other site 321967003705 G4 box; other site 321967003706 G5 box; other site 321967003707 G1 box; other site 321967003708 Switch I region; other site 321967003709 G2 box; other site 321967003710 G3 box; other site 321967003711 Switch II region; other site 321967003712 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 321967003713 RNA/DNA hybrid binding site [nucleotide binding]; other site 321967003714 active site 321967003715 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 321967003716 DNA protecting protein DprA; Region: dprA; TIGR00732 321967003717 DNA topoisomerase I; Validated; Region: PRK05582 321967003718 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 321967003719 active site 321967003720 interdomain interaction site; other site 321967003721 putative metal-binding site [ion binding]; other site 321967003722 nucleotide binding site [chemical binding]; other site 321967003723 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 321967003724 domain I; other site 321967003725 DNA binding groove [nucleotide binding] 321967003726 phosphate binding site [ion binding]; other site 321967003727 domain II; other site 321967003728 domain III; other site 321967003729 nucleotide binding site [chemical binding]; other site 321967003730 catalytic site [active] 321967003731 domain IV; other site 321967003732 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 321967003733 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 321967003734 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 321967003735 Glucose inhibited division protein A; Region: GIDA; pfam01134 321967003736 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 321967003737 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 321967003738 active site 321967003739 Int/Topo IB signature motif; other site 321967003740 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 321967003741 active site 321967003742 HslU subunit interaction site [polypeptide binding]; other site 321967003743 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 321967003744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 321967003745 Walker A motif; other site 321967003746 ATP binding site [chemical binding]; other site 321967003747 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 321967003748 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 321967003749 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 321967003750 active site 321967003751 catalytic residues [active] 321967003752 membrane protein; Provisional; Region: PRK14392 321967003753 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 321967003754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 321967003755 Mg2+ binding site [ion binding]; other site 321967003756 G-X-G motif; other site 321967003757 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 321967003758 anchoring element; other site 321967003759 dimer interface [polypeptide binding]; other site 321967003760 ATP binding site [chemical binding]; other site 321967003761 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 321967003762 active site 321967003763 putative metal-binding site [ion binding]; other site 321967003764 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 321967003765 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 321967003766 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 321967003767 CAP-like domain; other site 321967003768 active site 321967003769 primary dimer interface [polypeptide binding]; other site 321967003770 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 321967003771 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 321967003772 Pyruvate formate lyase 1; Region: PFL1; cd01678 321967003773 coenzyme A binding site [chemical binding]; other site 321967003774 active site 321967003775 catalytic residues [active] 321967003776 glycine loop; other site 321967003777 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 321967003778 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 321967003779 FeS/SAM binding site; other site 321967003780 Transcriptional regulator [Transcription]; Region: LysR; COG0583 321967003781 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 321967003782 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 321967003783 dimerization interface [polypeptide binding]; other site 321967003784 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 321967003785 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 321967003786 DHHA2 domain; Region: DHHA2; pfam02833 321967003787 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 321967003788 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 321967003789 active site 321967003790 DNA binding site [nucleotide binding] 321967003791 Int/Topo IB signature motif; other site 321967003792 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 321967003793 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 321967003794 Walker A/P-loop; other site 321967003795 ATP binding site [chemical binding]; other site 321967003796 Q-loop/lid; other site 321967003797 ABC transporter signature motif; other site 321967003798 Walker B; other site 321967003799 D-loop; other site 321967003800 H-loop/switch region; other site 321967003801 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 321967003802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 321967003803 ATP binding site [chemical binding]; other site 321967003804 Mg2+ binding site [ion binding]; other site 321967003805 G-X-G motif; other site 321967003806 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 321967003807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 321967003808 active site 321967003809 phosphorylation site [posttranslational modification] 321967003810 intermolecular recognition site; other site 321967003811 dimerization interface [polypeptide binding]; other site 321967003812 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 321967003813 DNA binding site [nucleotide binding] 321967003814 H+ Antiporter protein; Region: 2A0121; TIGR00900 321967003815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967003816 putative substrate translocation pore; other site 321967003817 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967003818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 321967003819 Coenzyme A binding pocket [chemical binding]; other site 321967003820 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 321967003821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967003822 Coenzyme A binding pocket [chemical binding]; other site 321967003823 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 321967003824 dimer interface [polypeptide binding]; other site 321967003825 FMN binding site [chemical binding]; other site 321967003826 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 321967003827 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 321967003828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 321967003829 homodimer interface [polypeptide binding]; other site 321967003830 catalytic residue [active] 321967003831 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 321967003832 metal binding site [ion binding]; metal-binding site 321967003833 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 321967003834 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 321967003835 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 321967003836 substrate binding site [chemical binding]; other site 321967003837 glutamase interaction surface [polypeptide binding]; other site 321967003838 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 321967003839 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 321967003840 catalytic residues [active] 321967003841 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 321967003842 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 321967003843 putative active site [active] 321967003844 oxyanion strand; other site 321967003845 catalytic triad [active] 321967003846 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 321967003847 4-fold oligomerization interface [polypeptide binding]; other site 321967003848 putative active site pocket [active] 321967003849 metal binding residues [ion binding]; metal-binding site 321967003850 3-fold/trimer interface [polypeptide binding]; other site 321967003851 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 321967003852 histidinol dehydrogenase; Region: hisD; TIGR00069 321967003853 NAD binding site [chemical binding]; other site 321967003854 dimerization interface [polypeptide binding]; other site 321967003855 product binding site; other site 321967003856 substrate binding site [chemical binding]; other site 321967003857 zinc binding site [ion binding]; other site 321967003858 catalytic residues [active] 321967003859 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 321967003860 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 321967003861 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 321967003862 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 321967003863 dimer interface [polypeptide binding]; other site 321967003864 motif 1; other site 321967003865 active site 321967003866 motif 2; other site 321967003867 motif 3; other site 321967003868 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 321967003869 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 321967003870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 321967003871 homodimer interface [polypeptide binding]; other site 321967003872 catalytic residue [active] 321967003873 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 321967003874 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 321967003875 dimer interface [polypeptide binding]; other site 321967003876 ADP-ribose binding site [chemical binding]; other site 321967003877 active site 321967003878 nudix motif; other site 321967003879 metal binding site [ion binding]; metal-binding site 321967003880 EDD domain protein, DegV family; Region: DegV; TIGR00762 321967003881 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 321967003882 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 321967003883 Domain of unknown function (DUF814); Region: DUF814; pfam05670 321967003884 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535 321967003885 metal binding site [ion binding]; metal-binding site 321967003886 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 321967003887 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 321967003888 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 321967003889 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 321967003890 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 321967003891 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 321967003892 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 321967003893 E3 interaction surface; other site 321967003894 lipoyl attachment site [posttranslational modification]; other site 321967003895 e3 binding domain; Region: E3_binding; pfam02817 321967003896 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 321967003897 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 321967003898 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 321967003899 alpha subunit interface [polypeptide binding]; other site 321967003900 TPP binding site [chemical binding]; other site 321967003901 heterodimer interface [polypeptide binding]; other site 321967003902 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 321967003903 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 321967003904 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 321967003905 tetramer interface [polypeptide binding]; other site 321967003906 TPP-binding site [chemical binding]; other site 321967003907 heterodimer interface [polypeptide binding]; other site 321967003908 phosphorylation loop region [posttranslational modification] 321967003909 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 321967003910 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 321967003911 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 321967003912 butyrate kinase; Provisional; Region: PRK03011 321967003913 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 321967003914 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 321967003915 active site 321967003916 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 321967003917 active site 321967003918 dimer interface [polypeptide binding]; other site 321967003919 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 321967003920 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 321967003921 heterodimer interface [polypeptide binding]; other site 321967003922 active site 321967003923 FMN binding site [chemical binding]; other site 321967003924 homodimer interface [polypeptide binding]; other site 321967003925 substrate binding site [chemical binding]; other site 321967003926 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 321967003927 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 321967003928 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 321967003929 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 321967003930 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 321967003931 ATP-grasp domain; Region: ATP-grasp_4; cl17255 321967003932 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 321967003933 IMP binding site; other site 321967003934 dimer interface [polypeptide binding]; other site 321967003935 interdomain contacts; other site 321967003936 partial ornithine binding site; other site 321967003937 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 321967003938 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 321967003939 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 321967003940 catalytic site [active] 321967003941 subunit interface [polypeptide binding]; other site 321967003942 dihydroorotase; Validated; Region: pyrC; PRK09357 321967003943 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 321967003944 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 321967003945 active site 321967003946 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 321967003947 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 321967003948 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 321967003949 uracil transporter; Provisional; Region: PRK10720 321967003950 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 321967003951 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 321967003952 active site 321967003953 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 321967003954 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 321967003955 RNA binding surface [nucleotide binding]; other site 321967003956 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 321967003957 active site 321967003958 lipoprotein signal peptidase; Provisional; Region: PRK14797 321967003959 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 321967003960 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 321967003961 Potassium binding sites [ion binding]; other site 321967003962 Cesium cation binding sites [ion binding]; other site 321967003963 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 321967003964 RNA/DNA hybrid binding site [nucleotide binding]; other site 321967003965 active site 321967003966 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 321967003967 dimer interface [polypeptide binding]; other site 321967003968 FMN binding site [chemical binding]; other site 321967003969 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 321967003970 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 321967003971 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 321967003972 putative active site [active] 321967003973 catalytic site [active] 321967003974 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 321967003975 putative active site [active] 321967003976 catalytic site [active] 321967003977 cytochrome c-550; Provisional; Region: psbV; cl17239 321967003978 Mga helix-turn-helix domain; Region: Mga; pfam05043 321967003979 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 321967003980 catalytic residues [active] 321967003981 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 321967003982 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 321967003983 Class I ribonucleotide reductase; Region: RNR_I; cd01679 321967003984 active site 321967003985 dimer interface [polypeptide binding]; other site 321967003986 catalytic residues [active] 321967003987 effector binding site; other site 321967003988 R2 peptide binding site; other site 321967003989 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 321967003990 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 321967003991 dimer interface [polypeptide binding]; other site 321967003992 putative radical transfer pathway; other site 321967003993 diiron center [ion binding]; other site 321967003994 tyrosyl radical; other site 321967003995 Transcriptional regulator [Transcription]; Region: LysR; COG0583 321967003996 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 321967003997 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 321967003998 dimerization interface [polypeptide binding]; other site 321967003999 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 321967004000 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 321967004001 active site 321967004002 Zn binding site [ion binding]; other site 321967004003 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 321967004004 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 321967004005 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 321967004006 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 321967004007 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 321967004008 putative ligand binding site [chemical binding]; other site 321967004009 NAD binding site [chemical binding]; other site 321967004010 catalytic site [active] 321967004011 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 321967004012 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 321967004013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 321967004014 cell division protein GpsB; Provisional; Region: PRK14127 321967004015 DivIVA domain; Region: DivI1A_domain; TIGR03544 321967004016 hypothetical protein; Provisional; Region: PRK13660 321967004017 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 321967004018 Transglycosylase; Region: Transgly; pfam00912 321967004019 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 321967004020 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 321967004021 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 321967004022 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 321967004023 minor groove reading motif; other site 321967004024 helix-hairpin-helix signature motif; other site 321967004025 substrate binding pocket [chemical binding]; other site 321967004026 active site 321967004027 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 321967004028 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 321967004029 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 321967004030 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 321967004031 putative dimer interface [polypeptide binding]; other site 321967004032 putative anticodon binding site; other site 321967004033 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 321967004034 homodimer interface [polypeptide binding]; other site 321967004035 motif 1; other site 321967004036 motif 2; other site 321967004037 active site 321967004038 motif 3; other site 321967004039 aspartate aminotransferase; Provisional; Region: PRK05764 321967004040 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 321967004041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 321967004042 homodimer interface [polypeptide binding]; other site 321967004043 catalytic residue [active] 321967004044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 321967004045 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 321967004046 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 321967004047 active site 321967004048 catalytic site [active] 321967004049 substrate binding site [chemical binding]; other site 321967004050 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 321967004051 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 321967004052 DEAD/DEAH box helicase; Region: DEAD; pfam00270 321967004053 ATP binding site [chemical binding]; other site 321967004054 Family description; Region: UvrD_C_2; pfam13538 321967004055 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 321967004056 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 321967004057 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 321967004058 mevalonate kinase; Region: mevalon_kin; TIGR00549 321967004059 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 321967004060 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 321967004061 diphosphomevalonate decarboxylase; Region: PLN02407 321967004062 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 321967004063 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 321967004064 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 321967004065 homotetramer interface [polypeptide binding]; other site 321967004066 FMN binding site [chemical binding]; other site 321967004067 homodimer contacts [polypeptide binding]; other site 321967004068 putative active site [active] 321967004069 putative substrate binding site [chemical binding]; other site 321967004070 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 321967004071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967004072 S-adenosylmethionine binding site [chemical binding]; other site 321967004073 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 321967004074 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 321967004075 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 321967004076 active site 1 [active] 321967004077 dimer interface [polypeptide binding]; other site 321967004078 hexamer interface [polypeptide binding]; other site 321967004079 active site 2 [active] 321967004080 Uncharacterized conserved protein [Function unknown]; Region: COG0327 321967004081 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 321967004082 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 321967004083 Family of unknown function (DUF633); Region: DUF633; pfam04816 321967004084 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 321967004085 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 321967004086 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 321967004087 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 321967004088 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 321967004089 DNA binding residues [nucleotide binding] 321967004090 DNA primase; Validated; Region: dnaG; PRK05667 321967004091 CHC2 zinc finger; Region: zf-CHC2; pfam01807 321967004092 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 321967004093 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 321967004094 active site 321967004095 metal binding site [ion binding]; metal-binding site 321967004096 interdomain interaction site; other site 321967004097 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 321967004098 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 321967004099 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 321967004100 dimer interface [polypeptide binding]; other site 321967004101 motif 1; other site 321967004102 active site 321967004103 motif 2; other site 321967004104 motif 3; other site 321967004105 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967004106 non-specific DNA binding site [nucleotide binding]; other site 321967004107 salt bridge; other site 321967004108 sequence-specific DNA binding site [nucleotide binding]; other site 321967004109 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 321967004110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 321967004111 Transposase; Region: DDE_Tnp_ISL3; pfam01610 321967004112 Recombination protein O N terminal; Region: RecO_N; pfam11967 321967004113 DNA repair protein RecO; Region: reco; TIGR00613 321967004114 Recombination protein O C terminal; Region: RecO_C; pfam02565 321967004115 GTPase Era; Reviewed; Region: era; PRK00089 321967004116 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 321967004117 G1 box; other site 321967004118 GTP/Mg2+ binding site [chemical binding]; other site 321967004119 Switch I region; other site 321967004120 G2 box; other site 321967004121 Switch II region; other site 321967004122 G3 box; other site 321967004123 G4 box; other site 321967004124 G5 box; other site 321967004125 KH domain; Region: KH_2; pfam07650 321967004126 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 321967004127 active site 321967004128 catalytic motif [active] 321967004129 Zn binding site [ion binding]; other site 321967004130 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 321967004131 metal-binding heat shock protein; Provisional; Region: PRK00016 321967004132 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 321967004133 PhoH-like protein; Region: PhoH; pfam02562 321967004134 Yqey-like protein; Region: YqeY; pfam09424 321967004135 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 321967004136 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 321967004137 endonuclease IV; Provisional; Region: PRK01060 321967004138 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 321967004139 AP (apurinic/apyrimidinic) site pocket; other site 321967004140 DNA interaction; other site 321967004141 Metal-binding active site; metal-binding site 321967004142 Uncharacterized conserved protein [Function unknown]; Region: COG1284 321967004143 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 321967004144 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 321967004145 methionine sulfoxide reductase B; Provisional; Region: PRK00222 321967004146 SelR domain; Region: SelR; pfam01641 321967004147 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 321967004148 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 321967004149 dimer interface [polypeptide binding]; other site 321967004150 anticodon binding site; other site 321967004151 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 321967004152 homodimer interface [polypeptide binding]; other site 321967004153 motif 1; other site 321967004154 active site 321967004155 motif 2; other site 321967004156 GAD domain; Region: GAD; pfam02938 321967004157 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 321967004158 motif 3; other site 321967004159 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 321967004160 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 321967004161 dimer interface [polypeptide binding]; other site 321967004162 motif 1; other site 321967004163 active site 321967004164 motif 2; other site 321967004165 motif 3; other site 321967004166 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 321967004167 anticodon binding site; other site 321967004168 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 321967004169 metal binding sites [ion binding]; metal-binding site 321967004170 dimer interface [polypeptide binding]; other site 321967004171 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 321967004172 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 321967004173 putative NAD(P) binding site [chemical binding]; other site 321967004174 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 321967004175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967004176 non-specific DNA binding site [nucleotide binding]; other site 321967004177 salt bridge; other site 321967004178 sequence-specific DNA binding site [nucleotide binding]; other site 321967004179 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 321967004180 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 321967004181 Walker A/P-loop; other site 321967004182 ATP binding site [chemical binding]; other site 321967004183 Q-loop/lid; other site 321967004184 ABC transporter signature motif; other site 321967004185 Walker B; other site 321967004186 D-loop; other site 321967004187 H-loop/switch region; other site 321967004188 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 321967004189 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 321967004190 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 321967004191 Bacterial SH3 domain; Region: SH3_3; pfam08239 321967004192 Bacterial SH3 domain; Region: SH3_3; pfam08239 321967004193 Bacterial SH3 domain homologues; Region: SH3b; smart00287 321967004194 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 321967004195 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 321967004196 active site 321967004197 metal binding site [ion binding]; metal-binding site 321967004198 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 321967004199 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967004200 motif II; other site 321967004201 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 321967004202 putative active site [active] 321967004203 dimerization interface [polypeptide binding]; other site 321967004204 putative tRNAtyr binding site [nucleotide binding]; other site 321967004205 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 321967004206 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 321967004207 Zn2+ binding site [ion binding]; other site 321967004208 Mg2+ binding site [ion binding]; other site 321967004209 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 321967004210 synthetase active site [active] 321967004211 NTP binding site [chemical binding]; other site 321967004212 metal binding site [ion binding]; metal-binding site 321967004213 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 321967004214 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 321967004215 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 321967004216 RNA methyltransferase, RsmE family; Region: TIGR00046 321967004217 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 321967004218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967004219 S-adenosylmethionine binding site [chemical binding]; other site 321967004220 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 321967004221 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 321967004222 active site 321967004223 DNA binding site [nucleotide binding] 321967004224 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 321967004225 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 321967004226 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 321967004227 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 321967004228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 321967004229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 321967004230 WHG domain; Region: WHG; pfam13305 321967004231 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 321967004232 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 321967004233 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 321967004234 putative deacylase active site [active] 321967004235 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 321967004236 active site 321967004237 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 321967004238 DHH family; Region: DHH; pfam01368 321967004239 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 321967004240 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 321967004241 GTP-binding protein LepA; Provisional; Region: PRK05433 321967004242 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 321967004243 G1 box; other site 321967004244 putative GEF interaction site [polypeptide binding]; other site 321967004245 GTP/Mg2+ binding site [chemical binding]; other site 321967004246 Switch I region; other site 321967004247 G2 box; other site 321967004248 G3 box; other site 321967004249 Switch II region; other site 321967004250 G4 box; other site 321967004251 G5 box; other site 321967004252 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 321967004253 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 321967004254 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 321967004255 chaperone protein DnaJ; Provisional; Region: PRK14276 321967004256 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 321967004257 HSP70 interaction site [polypeptide binding]; other site 321967004258 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 321967004259 substrate binding site [polypeptide binding]; other site 321967004260 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 321967004261 Zn binding sites [ion binding]; other site 321967004262 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 321967004263 dimer interface [polypeptide binding]; other site 321967004264 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 321967004265 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 321967004266 nucleotide binding site [chemical binding]; other site 321967004267 NEF interaction site [polypeptide binding]; other site 321967004268 SBD interface [polypeptide binding]; other site 321967004269 GrpE; Region: GrpE; pfam01025 321967004270 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 321967004271 dimer interface [polypeptide binding]; other site 321967004272 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 321967004273 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 321967004274 HTH domain; Region: HTH_11; pfam08279 321967004275 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 321967004276 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 321967004277 FeS/SAM binding site; other site 321967004278 HemN C-terminal domain; Region: HemN_C; pfam06969 321967004279 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 321967004280 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 321967004281 active site 321967004282 Riboflavin kinase; Region: Flavokinase; smart00904 321967004283 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 321967004284 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 321967004285 RNA binding site [nucleotide binding]; other site 321967004286 active site 321967004287 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 321967004288 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 321967004289 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 321967004290 translation initiation factor IF-2; Region: IF-2; TIGR00487 321967004291 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 321967004292 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 321967004293 G1 box; other site 321967004294 putative GEF interaction site [polypeptide binding]; other site 321967004295 GTP/Mg2+ binding site [chemical binding]; other site 321967004296 Switch I region; other site 321967004297 G2 box; other site 321967004298 G3 box; other site 321967004299 Switch II region; other site 321967004300 G4 box; other site 321967004301 G5 box; other site 321967004302 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 321967004303 Translation-initiation factor 2; Region: IF-2; pfam11987 321967004304 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 321967004305 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 321967004306 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 321967004307 putative RNA binding cleft [nucleotide binding]; other site 321967004308 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 321967004309 NusA N-terminal domain; Region: NusA_N; pfam08529 321967004310 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 321967004311 RNA binding site [nucleotide binding]; other site 321967004312 homodimer interface [polypeptide binding]; other site 321967004313 NusA-like KH domain; Region: KH_5; pfam13184 321967004314 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 321967004315 G-X-X-G motif; other site 321967004316 ribosome maturation protein RimP; Reviewed; Region: PRK00092 321967004317 Sm and related proteins; Region: Sm_like; cl00259 321967004318 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 321967004319 putative oligomer interface [polypeptide binding]; other site 321967004320 putative RNA binding site [nucleotide binding]; other site 321967004321 DNA polymerase III PolC; Validated; Region: polC; PRK00448 321967004322 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 321967004323 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 321967004324 generic binding surface II; other site 321967004325 generic binding surface I; other site 321967004326 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 321967004327 active site 321967004328 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 321967004329 active site 321967004330 catalytic site [active] 321967004331 substrate binding site [chemical binding]; other site 321967004332 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 321967004333 prolyl-tRNA synthetase; Provisional; Region: PRK09194 321967004334 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 321967004335 dimer interface [polypeptide binding]; other site 321967004336 motif 1; other site 321967004337 active site 321967004338 motif 2; other site 321967004339 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 321967004340 putative deacylase active site [active] 321967004341 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 321967004342 active site 321967004343 motif 3; other site 321967004344 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 321967004345 anticodon binding site; other site 321967004346 RIP metalloprotease RseP; Region: TIGR00054 321967004347 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 321967004348 active site 321967004349 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 321967004350 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 321967004351 protein binding site [polypeptide binding]; other site 321967004352 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 321967004353 putative substrate binding region [chemical binding]; other site 321967004354 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 321967004355 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 321967004356 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 321967004357 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 321967004358 catalytic residue [active] 321967004359 putative FPP diphosphate binding site; other site 321967004360 putative FPP binding hydrophobic cleft; other site 321967004361 dimer interface [polypeptide binding]; other site 321967004362 putative IPP diphosphate binding site; other site 321967004363 ribosome recycling factor; Reviewed; Region: frr; PRK00083 321967004364 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 321967004365 hinge region; other site 321967004366 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 321967004367 putative nucleotide binding site [chemical binding]; other site 321967004368 uridine monophosphate binding site [chemical binding]; other site 321967004369 homohexameric interface [polypeptide binding]; other site 321967004370 elongation factor Ts; Provisional; Region: tsf; PRK09377 321967004371 UBA/TS-N domain; Region: UBA; pfam00627 321967004372 Elongation factor TS; Region: EF_TS; pfam00889 321967004373 Elongation factor TS; Region: EF_TS; pfam00889 321967004374 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 321967004375 rRNA interaction site [nucleotide binding]; other site 321967004376 S8 interaction site; other site 321967004377 putative laminin-1 binding site; other site 321967004378 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 321967004379 GIY-YIG motif/motif A; other site 321967004380 putative active site [active] 321967004381 putative metal binding site [ion binding]; other site 321967004382 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 321967004383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967004384 S-adenosylmethionine binding site [chemical binding]; other site 321967004385 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 321967004386 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 321967004387 putative acyl-acceptor binding pocket; other site 321967004388 amino acid transporter; Region: 2A0306; TIGR00909 321967004389 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 321967004390 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 321967004391 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 321967004392 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 321967004393 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 321967004394 Walker A/P-loop; other site 321967004395 ATP binding site [chemical binding]; other site 321967004396 Q-loop/lid; other site 321967004397 ABC transporter signature motif; other site 321967004398 Walker B; other site 321967004399 D-loop; other site 321967004400 H-loop/switch region; other site 321967004401 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 321967004402 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 321967004403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967004404 Walker A/P-loop; other site 321967004405 ATP binding site [chemical binding]; other site 321967004406 Q-loop/lid; other site 321967004407 ABC transporter signature motif; other site 321967004408 Walker B; other site 321967004409 D-loop; other site 321967004410 H-loop/switch region; other site 321967004411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 321967004412 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 321967004413 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 321967004414 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 321967004415 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 321967004416 RimM N-terminal domain; Region: RimM; pfam01782 321967004417 PRC-barrel domain; Region: PRC; pfam05239 321967004418 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 321967004419 KH domain; Region: KH_4; pfam13083 321967004420 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 321967004421 signal recognition particle protein; Provisional; Region: PRK10867 321967004422 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 321967004423 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 321967004424 P loop; other site 321967004425 GTP binding site [chemical binding]; other site 321967004426 Signal peptide binding domain; Region: SRP_SPB; pfam02978 321967004427 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 321967004428 putative DNA-binding protein; Validated; Region: PRK00118 321967004429 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 321967004430 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 321967004431 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 321967004432 P loop; other site 321967004433 GTP binding site [chemical binding]; other site 321967004434 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 321967004435 AAA domain; Region: AAA_23; pfam13476 321967004436 Walker A/P-loop; other site 321967004437 ATP binding site [chemical binding]; other site 321967004438 Q-loop/lid; other site 321967004439 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 321967004440 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 321967004441 ABC transporter signature motif; other site 321967004442 Walker B; other site 321967004443 D-loop; other site 321967004444 H-loop/switch region; other site 321967004445 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 321967004446 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 321967004447 dimerization interface [polypeptide binding]; other site 321967004448 active site 321967004449 metal binding site [ion binding]; metal-binding site 321967004450 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 321967004451 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 321967004452 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 321967004453 peptide binding site [polypeptide binding]; other site 321967004454 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 321967004455 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 321967004456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967004457 dimer interface [polypeptide binding]; other site 321967004458 conserved gate region; other site 321967004459 putative PBP binding loops; other site 321967004460 ABC-ATPase subunit interface; other site 321967004461 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 321967004462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967004463 dimer interface [polypeptide binding]; other site 321967004464 conserved gate region; other site 321967004465 putative PBP binding loops; other site 321967004466 ABC-ATPase subunit interface; other site 321967004467 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 321967004468 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 321967004469 Walker A/P-loop; other site 321967004470 ATP binding site [chemical binding]; other site 321967004471 Q-loop/lid; other site 321967004472 ABC transporter signature motif; other site 321967004473 Walker B; other site 321967004474 D-loop; other site 321967004475 H-loop/switch region; other site 321967004476 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 321967004477 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 321967004478 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 321967004479 Walker A/P-loop; other site 321967004480 ATP binding site [chemical binding]; other site 321967004481 Q-loop/lid; other site 321967004482 ABC transporter signature motif; other site 321967004483 Walker B; other site 321967004484 D-loop; other site 321967004485 H-loop/switch region; other site 321967004486 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 321967004487 acyl carrier protein; Provisional; Region: acpP; PRK00982 321967004488 putative phosphate acyltransferase; Provisional; Region: PRK05331 321967004489 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 321967004490 Y-family of DNA polymerases; Region: PolY; cl12025 321967004491 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 321967004492 generic binding surface II; other site 321967004493 ssDNA binding site; other site 321967004494 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 321967004495 ATP binding site [chemical binding]; other site 321967004496 putative Mg++ binding site [ion binding]; other site 321967004497 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 321967004498 nucleotide binding region [chemical binding]; other site 321967004499 ATP-binding site [chemical binding]; other site 321967004500 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 321967004501 DAK2 domain; Region: Dak2; pfam02734 321967004502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 321967004503 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 321967004504 Thiamine pyrophosphokinase; Region: TPK; cd07995 321967004505 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 321967004506 active site 321967004507 dimerization interface [polypeptide binding]; other site 321967004508 thiamine binding site [chemical binding]; other site 321967004509 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 321967004510 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 321967004511 substrate binding site [chemical binding]; other site 321967004512 hexamer interface [polypeptide binding]; other site 321967004513 metal binding site [ion binding]; metal-binding site 321967004514 GTPase RsgA; Reviewed; Region: PRK00098 321967004515 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 321967004516 RNA binding site [nucleotide binding]; other site 321967004517 homodimer interface [polypeptide binding]; other site 321967004518 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 321967004519 GTPase/Zn-binding domain interface [polypeptide binding]; other site 321967004520 GTP/Mg2+ binding site [chemical binding]; other site 321967004521 G4 box; other site 321967004522 G5 box; other site 321967004523 G1 box; other site 321967004524 Switch I region; other site 321967004525 G2 box; other site 321967004526 G3 box; other site 321967004527 Switch II region; other site 321967004528 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 321967004529 Catalytic domain of Protein Kinases; Region: PKc; cd00180 321967004530 active site 321967004531 ATP binding site [chemical binding]; other site 321967004532 substrate binding site [chemical binding]; other site 321967004533 activation loop (A-loop); other site 321967004534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 321967004535 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 321967004536 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 321967004537 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 321967004538 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 321967004539 active site 321967004540 16S rRNA methyltransferase B; Provisional; Region: PRK14902 321967004541 NusB family; Region: NusB; pfam01029 321967004542 putative RNA binding site [nucleotide binding]; other site 321967004543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967004544 S-adenosylmethionine binding site [chemical binding]; other site 321967004545 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 321967004546 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 321967004547 putative active site [active] 321967004548 substrate binding site [chemical binding]; other site 321967004549 putative cosubstrate binding site; other site 321967004550 catalytic site [active] 321967004551 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 321967004552 substrate binding site [chemical binding]; other site 321967004553 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 321967004554 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 321967004555 ATP binding site [chemical binding]; other site 321967004556 putative Mg++ binding site [ion binding]; other site 321967004557 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 321967004558 nucleotide binding region [chemical binding]; other site 321967004559 ATP-binding site [chemical binding]; other site 321967004560 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 321967004561 Flavoprotein; Region: Flavoprotein; pfam02441 321967004562 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 321967004563 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 321967004564 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 321967004565 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 321967004566 catalytic site [active] 321967004567 G-X2-G-X-G-K; other site 321967004568 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 321967004569 nucleophile elbow; other site 321967004570 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 321967004571 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 321967004572 Walker A/P-loop; other site 321967004573 ATP binding site [chemical binding]; other site 321967004574 Q-loop/lid; other site 321967004575 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 321967004576 ABC transporter signature motif; other site 321967004577 Walker B; other site 321967004578 D-loop; other site 321967004579 H-loop/switch region; other site 321967004580 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 321967004581 arginine repressor; Provisional; Region: PRK04280 321967004582 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 321967004583 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 321967004584 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 321967004585 RNA binding surface [nucleotide binding]; other site 321967004586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967004587 S-adenosylmethionine binding site [chemical binding]; other site 321967004588 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 321967004589 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 321967004590 substrate binding pocket [chemical binding]; other site 321967004591 chain length determination region; other site 321967004592 substrate-Mg2+ binding site; other site 321967004593 catalytic residues [active] 321967004594 aspartate-rich region 1; other site 321967004595 active site lid residues [active] 321967004596 aspartate-rich region 2; other site 321967004597 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 321967004598 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 321967004599 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 321967004600 generic binding surface II; other site 321967004601 generic binding surface I; other site 321967004602 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14169 321967004603 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 321967004604 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 321967004605 homodimer interface [polypeptide binding]; other site 321967004606 NADP binding site [chemical binding]; other site 321967004607 substrate binding site [chemical binding]; other site 321967004608 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 321967004609 putative RNA binding site [nucleotide binding]; other site 321967004610 Asp23 family; Region: Asp23; pfam03780 321967004611 elongation factor P; Validated; Region: PRK00529 321967004612 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 321967004613 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 321967004614 RNA binding site [nucleotide binding]; other site 321967004615 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 321967004616 RNA binding site [nucleotide binding]; other site 321967004617 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 321967004618 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 321967004619 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 321967004620 active site 321967004621 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 321967004622 Protein of unknown function (DUF464); Region: DUF464; pfam04327 321967004623 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 321967004624 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 321967004625 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 321967004626 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 321967004627 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 321967004628 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 321967004629 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 321967004630 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 321967004631 DNA binding residues [nucleotide binding] 321967004632 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 321967004633 putative dimer interface [polypeptide binding]; other site 321967004634 ornithine decarboxylase; Provisional; Region: PRK13578 321967004635 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 321967004636 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 321967004637 catalytic residue [active] 321967004638 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 321967004639 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 321967004640 Aluminium resistance protein; Region: Alum_res; pfam06838 321967004641 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 321967004642 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 321967004643 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 321967004644 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 321967004645 active site residue [active] 321967004646 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 321967004647 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 321967004648 nucleotide binding site [chemical binding]; other site 321967004649 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 321967004650 Rhomboid family; Region: Rhomboid; pfam01694 321967004651 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 321967004652 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 321967004653 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 321967004654 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 321967004655 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 321967004656 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 321967004657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 321967004658 active site 321967004659 phosphorylation site [posttranslational modification] 321967004660 intermolecular recognition site; other site 321967004661 dimerization interface [polypeptide binding]; other site 321967004662 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 321967004663 DNA binding residues [nucleotide binding] 321967004664 dimerization interface [polypeptide binding]; other site 321967004665 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 321967004666 Histidine kinase; Region: HisKA_3; pfam07730 321967004667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 321967004668 ATP binding site [chemical binding]; other site 321967004669 Mg2+ binding site [ion binding]; other site 321967004670 G-X-G motif; other site 321967004671 Predicted membrane protein [Function unknown]; Region: COG4758 321967004672 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 321967004673 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 321967004674 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 321967004675 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 321967004676 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 321967004677 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 321967004678 ATP-binding site [chemical binding]; other site 321967004679 Sugar specificity; other site 321967004680 Pyrimidine base specificity; other site 321967004681 YceG-like family; Region: YceG; pfam02618 321967004682 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 321967004683 dimerization interface [polypeptide binding]; other site 321967004684 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 321967004685 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 321967004686 putative tRNA-binding site [nucleotide binding]; other site 321967004687 B3/4 domain; Region: B3_4; pfam03483 321967004688 tRNA synthetase B5 domain; Region: B5; smart00874 321967004689 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 321967004690 dimer interface [polypeptide binding]; other site 321967004691 motif 1; other site 321967004692 motif 3; other site 321967004693 motif 2; other site 321967004694 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 321967004695 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 321967004696 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 321967004697 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 321967004698 dimer interface [polypeptide binding]; other site 321967004699 motif 1; other site 321967004700 active site 321967004701 motif 2; other site 321967004702 motif 3; other site 321967004703 Predicted transcriptional regulators [Transcription]; Region: COG1733 321967004704 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 321967004705 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 321967004706 Zn2+ binding site [ion binding]; other site 321967004707 Mg2+ binding site [ion binding]; other site 321967004708 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 321967004709 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 321967004710 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 321967004711 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 321967004712 OxaA-like protein precursor; Provisional; Region: PRK02463 321967004713 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 321967004714 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 321967004715 HAMP domain; Region: HAMP; pfam00672 321967004716 dimerization interface [polypeptide binding]; other site 321967004717 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 321967004718 dimer interface [polypeptide binding]; other site 321967004719 phosphorylation site [posttranslational modification] 321967004720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 321967004721 ATP binding site [chemical binding]; other site 321967004722 Mg2+ binding site [ion binding]; other site 321967004723 G-X-G motif; other site 321967004724 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 321967004725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 321967004726 active site 321967004727 phosphorylation site [posttranslational modification] 321967004728 intermolecular recognition site; other site 321967004729 dimerization interface [polypeptide binding]; other site 321967004730 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 321967004731 DNA binding site [nucleotide binding] 321967004732 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967004733 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967004734 Integrase core domain; Region: rve; pfam00665 321967004735 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 321967004736 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 321967004737 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 321967004738 Protein of unknown function (DUF3781); Region: DUF3781; pfam12636 321967004739 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 321967004740 hypothetical protein; Provisional; Region: PRK13670 321967004741 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 321967004742 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 321967004743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967004744 S-adenosylmethionine binding site [chemical binding]; other site 321967004745 Oligomerisation domain; Region: Oligomerisation; pfam02410 321967004746 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 321967004747 Zn2+ binding site [ion binding]; other site 321967004748 Mg2+ binding site [ion binding]; other site 321967004749 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 321967004750 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 321967004751 active site 321967004752 (T/H)XGH motif; other site 321967004753 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 321967004754 GTPase YqeH; Provisional; Region: PRK13796 321967004755 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 321967004756 GTP/Mg2+ binding site [chemical binding]; other site 321967004757 G4 box; other site 321967004758 G5 box; other site 321967004759 G1 box; other site 321967004760 Switch I region; other site 321967004761 G2 box; other site 321967004762 G3 box; other site 321967004763 Switch II region; other site 321967004764 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 321967004765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967004766 active site 321967004767 motif I; other site 321967004768 motif II; other site 321967004769 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 321967004770 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 321967004771 Zn binding site [ion binding]; other site 321967004772 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 321967004773 Zn binding site [ion binding]; other site 321967004774 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 321967004775 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 321967004776 Zn binding site [ion binding]; other site 321967004777 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 321967004778 Zn binding site [ion binding]; other site 321967004779 Predicted esterase [General function prediction only]; Region: COG0400 321967004780 putative hydrolase; Provisional; Region: PRK11460 321967004781 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 321967004782 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 321967004783 putative NAD(P) binding site [chemical binding]; other site 321967004784 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 321967004785 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 321967004786 23S rRNA binding site [nucleotide binding]; other site 321967004787 L21 binding site [polypeptide binding]; other site 321967004788 L13 binding site [polypeptide binding]; other site 321967004789 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 321967004790 translation initiation factor IF-3; Region: infC; TIGR00168 321967004791 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 321967004792 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 321967004793 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 321967004794 catalytic core [active] 321967004795 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 321967004796 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 321967004797 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 321967004798 active site 321967004799 dimer interface [polypeptide binding]; other site 321967004800 motif 1; other site 321967004801 motif 2; other site 321967004802 motif 3; other site 321967004803 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 321967004804 anticodon binding site; other site 321967004805 primosomal protein DnaI; Reviewed; Region: PRK08939 321967004806 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 321967004807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 321967004808 Walker A motif; other site 321967004809 ATP binding site [chemical binding]; other site 321967004810 Walker B motif; other site 321967004811 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 321967004812 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 321967004813 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 321967004814 ATP cone domain; Region: ATP-cone; pfam03477 321967004815 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 321967004816 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 321967004817 CoA-binding site [chemical binding]; other site 321967004818 ATP-binding [chemical binding]; other site 321967004819 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 321967004820 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 321967004821 DNA binding site [nucleotide binding] 321967004822 catalytic residue [active] 321967004823 H2TH interface [polypeptide binding]; other site 321967004824 putative catalytic residues [active] 321967004825 turnover-facilitating residue; other site 321967004826 intercalation triad [nucleotide binding]; other site 321967004827 8OG recognition residue [nucleotide binding]; other site 321967004828 putative reading head residues; other site 321967004829 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 321967004830 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 321967004831 DNA polymerase I; Provisional; Region: PRK05755 321967004832 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 321967004833 active site 321967004834 metal binding site 1 [ion binding]; metal-binding site 321967004835 putative 5' ssDNA interaction site; other site 321967004836 metal binding site 3; metal-binding site 321967004837 metal binding site 2 [ion binding]; metal-binding site 321967004838 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 321967004839 putative DNA binding site [nucleotide binding]; other site 321967004840 putative metal binding site [ion binding]; other site 321967004841 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 321967004842 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 321967004843 active site 321967004844 DNA binding site [nucleotide binding] 321967004845 catalytic site [active] 321967004846 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 321967004847 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 321967004848 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 321967004849 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 321967004850 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 321967004851 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 321967004852 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 321967004853 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 321967004854 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 321967004855 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 321967004856 putative tRNA-binding site [nucleotide binding]; other site 321967004857 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 321967004858 catalytic residues [active] 321967004859 Predicted small secreted protein [Function unknown]; Region: COG5584 321967004860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967004861 S-adenosylmethionine binding site [chemical binding]; other site 321967004862 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 321967004863 Phosphotransferase enzyme family; Region: APH; pfam01636 321967004864 substrate binding site [chemical binding]; other site 321967004865 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 321967004866 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 321967004867 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 321967004868 Walker A/P-loop; other site 321967004869 ATP binding site [chemical binding]; other site 321967004870 Q-loop/lid; other site 321967004871 ABC transporter signature motif; other site 321967004872 Walker B; other site 321967004873 D-loop; other site 321967004874 H-loop/switch region; other site 321967004875 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 321967004876 HIT family signature motif; other site 321967004877 catalytic residue [active] 321967004878 YtxH-like protein; Region: YtxH; pfam12732 321967004879 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 321967004880 SurA N-terminal domain; Region: SurA_N_3; cl07813 321967004881 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 321967004882 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 321967004883 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 321967004884 generic binding surface I; other site 321967004885 generic binding surface II; other site 321967004886 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 321967004887 Zn2+ binding site [ion binding]; other site 321967004888 Mg2+ binding site [ion binding]; other site 321967004889 Protein of unknown function (DUF964); Region: DUF964; cl01483 321967004890 Transglycosylase; Region: Transgly; pfam00912 321967004891 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 321967004892 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 321967004893 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 321967004894 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 321967004895 active site 321967004896 Arginine repressor [Transcription]; Region: ArgR; COG1438 321967004897 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 321967004898 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 321967004899 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 321967004900 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 321967004901 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 321967004902 active site 321967004903 HIGH motif; other site 321967004904 KMSK motif region; other site 321967004905 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 321967004906 tRNA binding surface [nucleotide binding]; other site 321967004907 anticodon binding site; other site 321967004908 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 321967004909 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 321967004910 active site 321967004911 FMN binding site [chemical binding]; other site 321967004912 substrate binding site [chemical binding]; other site 321967004913 catalytic residues [active] 321967004914 homodimer interface [polypeptide binding]; other site 321967004915 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 321967004916 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 321967004917 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 321967004918 putative active site [active] 321967004919 catalytic site [active] 321967004920 putative metal binding site [ion binding]; other site 321967004921 adaptor protein; Provisional; Region: PRK02315 321967004922 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 321967004923 ArsC family; Region: ArsC; pfam03960 321967004924 putative catalytic residues [active] 321967004925 thiol/disulfide switch; other site 321967004926 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 321967004927 FtsX-like permease family; Region: FtsX; pfam02687 321967004928 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 321967004929 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 321967004930 Walker A/P-loop; other site 321967004931 ATP binding site [chemical binding]; other site 321967004932 Q-loop/lid; other site 321967004933 ABC transporter signature motif; other site 321967004934 Walker B; other site 321967004935 D-loop; other site 321967004936 H-loop/switch region; other site 321967004937 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 321967004938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 321967004939 active site 321967004940 phosphorylation site [posttranslational modification] 321967004941 intermolecular recognition site; other site 321967004942 dimerization interface [polypeptide binding]; other site 321967004943 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 321967004944 DNA binding site [nucleotide binding] 321967004945 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 321967004946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 321967004947 ATP binding site [chemical binding]; other site 321967004948 Mg2+ binding site [ion binding]; other site 321967004949 G-X-G motif; other site 321967004950 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 321967004951 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 321967004952 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 321967004953 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 321967004954 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 321967004955 Penicillinase repressor; Region: Pencillinase_R; pfam03965 321967004956 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 321967004957 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 321967004958 ATP-grasp domain; Region: ATP-grasp_4; cl17255 321967004959 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 321967004960 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 321967004961 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 321967004962 purine monophosphate binding site [chemical binding]; other site 321967004963 dimer interface [polypeptide binding]; other site 321967004964 putative catalytic residues [active] 321967004965 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 321967004966 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 321967004967 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 321967004968 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 321967004969 active site 321967004970 substrate binding site [chemical binding]; other site 321967004971 cosubstrate binding site; other site 321967004972 catalytic site [active] 321967004973 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 321967004974 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 321967004975 dimerization interface [polypeptide binding]; other site 321967004976 putative ATP binding site [chemical binding]; other site 321967004977 amidophosphoribosyltransferase; Provisional; Region: PRK07272 321967004978 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 321967004979 active site 321967004980 tetramer interface [polypeptide binding]; other site 321967004981 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 321967004982 active site 321967004983 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 321967004984 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 321967004985 dimerization interface [polypeptide binding]; other site 321967004986 ATP binding site [chemical binding]; other site 321967004987 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 321967004988 dimerization interface [polypeptide binding]; other site 321967004989 ATP binding site [chemical binding]; other site 321967004990 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 321967004991 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 321967004992 putative active site [active] 321967004993 catalytic triad [active] 321967004994 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 321967004995 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 321967004996 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 321967004997 ATP binding site [chemical binding]; other site 321967004998 active site 321967004999 substrate binding site [chemical binding]; other site 321967005000 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 321967005001 ATP-grasp domain; Region: ATP-grasp; pfam02222 321967005002 AIR carboxylase; Region: AIRC; pfam00731 321967005003 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 321967005004 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 321967005005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967005006 putative substrate translocation pore; other site 321967005007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967005008 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 321967005009 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 321967005010 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 321967005011 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 321967005012 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 321967005013 dimerization domain swap beta strand [polypeptide binding]; other site 321967005014 regulatory protein interface [polypeptide binding]; other site 321967005015 active site 321967005016 regulatory phosphorylation site [posttranslational modification]; other site 321967005017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 321967005018 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 321967005019 Walker A motif; other site 321967005020 ATP binding site [chemical binding]; other site 321967005021 Walker B motif; other site 321967005022 arginine finger; other site 321967005023 UvrB/uvrC motif; Region: UVR; pfam02151 321967005024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 321967005025 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 321967005026 Walker A motif; other site 321967005027 ATP binding site [chemical binding]; other site 321967005028 Walker B motif; other site 321967005029 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 321967005030 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 321967005031 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 321967005032 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 321967005033 G1 box; other site 321967005034 putative GEF interaction site [polypeptide binding]; other site 321967005035 GTP/Mg2+ binding site [chemical binding]; other site 321967005036 Switch I region; other site 321967005037 G2 box; other site 321967005038 G3 box; other site 321967005039 Switch II region; other site 321967005040 G4 box; other site 321967005041 G5 box; other site 321967005042 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 321967005043 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 321967005044 Domain of unknown function DUF21; Region: DUF21; pfam01595 321967005045 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 321967005046 Transporter associated domain; Region: CorC_HlyC; pfam03471 321967005047 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 321967005048 Domain of unknown function DUF20; Region: UPF0118; pfam01594 321967005049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967005050 Coenzyme A binding pocket [chemical binding]; other site 321967005051 hypothetical protein; Provisional; Region: PRK13662 321967005052 RecX family; Region: RecX; cl00936 321967005053 Mga helix-turn-helix domain; Region: Mga; pfam05043 321967005054 TRAM domain; Region: TRAM; pfam01938 321967005055 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 321967005056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967005057 S-adenosylmethionine binding site [chemical binding]; other site 321967005058 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 321967005059 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 321967005060 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 321967005061 DNA-binding site [nucleotide binding]; DNA binding site 321967005062 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 321967005063 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 321967005064 beta-galactosidase; Region: BGL; TIGR03356 321967005065 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 321967005066 active site 321967005067 methionine cluster; other site 321967005068 phosphorylation site [posttranslational modification] 321967005069 metal binding site [ion binding]; metal-binding site 321967005070 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 321967005071 active site 321967005072 P-loop; other site 321967005073 phosphorylation site [posttranslational modification] 321967005074 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 321967005075 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 321967005076 PYR/PP interface [polypeptide binding]; other site 321967005077 dimer interface [polypeptide binding]; other site 321967005078 tetramer interface [polypeptide binding]; other site 321967005079 TPP binding site [chemical binding]; other site 321967005080 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 321967005081 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 321967005082 TPP-binding site [chemical binding]; other site 321967005083 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 321967005084 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 321967005085 dimer interface [polypeptide binding]; other site 321967005086 active site 321967005087 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 321967005088 homodimer interface [polypeptide binding]; other site 321967005089 catalytic residues [active] 321967005090 NAD binding site [chemical binding]; other site 321967005091 substrate binding pocket [chemical binding]; other site 321967005092 flexible flap; other site 321967005093 putative acyltransferase; Provisional; Region: PRK05790 321967005094 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 321967005095 dimer interface [polypeptide binding]; other site 321967005096 active site 321967005097 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 321967005098 Restriction endonuclease; Region: Mrr_cat; pfam04471 321967005099 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 321967005100 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 321967005101 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 321967005102 metal binding site [ion binding]; metal-binding site 321967005103 dimer interface [polypeptide binding]; other site 321967005104 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 321967005105 Predicted membrane protein [Function unknown]; Region: COG4684 321967005106 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 321967005107 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967005108 Coenzyme A binding pocket [chemical binding]; other site 321967005109 hypothetical protein; Provisional; Region: PRK04351 321967005110 SprT homologues; Region: SprT; cl01182 321967005111 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 321967005112 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967005113 Walker A/P-loop; other site 321967005114 ATP binding site [chemical binding]; other site 321967005115 Q-loop/lid; other site 321967005116 ABC transporter signature motif; other site 321967005117 Walker B; other site 321967005118 D-loop; other site 321967005119 H-loop/switch region; other site 321967005120 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 321967005121 TM-ABC transporter signature motif; other site 321967005122 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 321967005123 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 321967005124 zinc binding site [ion binding]; other site 321967005125 putative ligand binding site [chemical binding]; other site 321967005126 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 321967005127 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 321967005128 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 321967005129 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 321967005130 Soluble P-type ATPase [General function prediction only]; Region: COG4087 321967005131 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 321967005132 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 321967005133 Beta-lactamase; Region: Beta-lactamase; pfam00144 321967005134 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967005135 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967005136 Integrase core domain; Region: rve; pfam00665 321967005137 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 321967005138 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 321967005139 homodimer interface [polypeptide binding]; other site 321967005140 NAD binding pocket [chemical binding]; other site 321967005141 ATP binding pocket [chemical binding]; other site 321967005142 Mg binding site [ion binding]; other site 321967005143 active-site loop [active] 321967005144 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 321967005145 Beta-lactamase; Region: Beta-lactamase; pfam00144 321967005146 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 321967005147 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 321967005148 active site 321967005149 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 321967005150 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 321967005151 DNA-binding site [nucleotide binding]; DNA binding site 321967005152 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 321967005153 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 321967005154 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 321967005155 active site 321967005156 dimer interface [polypeptide binding]; other site 321967005157 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 321967005158 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 321967005159 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 321967005160 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 321967005161 putative phosphoesterase; Region: acc_ester; TIGR03729 321967005162 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 321967005163 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 321967005164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967005165 putative substrate translocation pore; other site 321967005166 POT family; Region: PTR2; pfam00854 321967005167 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 321967005168 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 321967005169 Walker A/P-loop; other site 321967005170 ATP binding site [chemical binding]; other site 321967005171 Q-loop/lid; other site 321967005172 ABC transporter signature motif; other site 321967005173 Walker B; other site 321967005174 D-loop; other site 321967005175 H-loop/switch region; other site 321967005176 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 321967005177 FtsX-like permease family; Region: FtsX; pfam02687 321967005178 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 321967005179 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 321967005180 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 321967005181 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 321967005182 active site 321967005183 nucleotide-binding site [chemical binding]; other site 321967005184 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 321967005185 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 321967005186 G1 box; other site 321967005187 GTP/Mg2+ binding site [chemical binding]; other site 321967005188 Switch I region; other site 321967005189 G2 box; other site 321967005190 G3 box; other site 321967005191 Switch II region; other site 321967005192 G4 box; other site 321967005193 G5 box; other site 321967005194 Nucleoside recognition; Region: Gate; pfam07670 321967005195 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 321967005196 Nucleoside recognition; Region: Gate; pfam07670 321967005197 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 321967005198 catalytic triad [active] 321967005199 catalytic triad [active] 321967005200 oxyanion hole [active] 321967005201 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 321967005202 NADH(P)-binding; Region: NAD_binding_10; pfam13460 321967005203 NAD binding site [chemical binding]; other site 321967005204 substrate binding site [chemical binding]; other site 321967005205 putative active site [active] 321967005206 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 321967005207 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 321967005208 seryl-tRNA synthetase; Provisional; Region: PRK05431 321967005209 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 321967005210 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 321967005211 dimer interface [polypeptide binding]; other site 321967005212 active site 321967005213 motif 1; other site 321967005214 motif 2; other site 321967005215 motif 3; other site 321967005216 Mga helix-turn-helix domain; Region: Mga; pfam05043 321967005217 Mga helix-turn-helix domain; Region: Mga; pfam05043 321967005218 lysine transporter; Provisional; Region: PRK10836 321967005219 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 321967005220 acetolactate synthase; Reviewed; Region: PRK08617 321967005221 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 321967005222 PYR/PP interface [polypeptide binding]; other site 321967005223 dimer interface [polypeptide binding]; other site 321967005224 TPP binding site [chemical binding]; other site 321967005225 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 321967005226 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 321967005227 TPP-binding site [chemical binding]; other site 321967005228 dimer interface [polypeptide binding]; other site 321967005229 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 321967005230 Homeodomain-like domain; Region: HTH_23; pfam13384 321967005231 Transposase; Region: DDE_Tnp_ISL3; pfam01610 321967005232 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 321967005233 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 321967005234 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 321967005235 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 321967005236 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 321967005237 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 321967005238 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 321967005239 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 321967005240 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 321967005241 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 321967005242 active site 321967005243 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 321967005244 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 321967005245 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 321967005246 Transcriptional regulators [Transcription]; Region: GntR; COG1802 321967005247 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 321967005248 DNA-binding site [nucleotide binding]; DNA binding site 321967005249 FCD domain; Region: FCD; pfam07729 321967005250 oxaloacetate decarboxylase; Provisional; Region: PRK12331 321967005251 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 321967005252 active site 321967005253 catalytic residues [active] 321967005254 metal binding site [ion binding]; metal-binding site 321967005255 homodimer binding site [polypeptide binding]; other site 321967005256 2'-(5''-triphosphoribosyl)-3'- dephospho-CoA:apo-citrate lyase; Reviewed; Region: citX; PRK01392 321967005257 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 321967005258 Coenzyme A transferase; Region: CoA_trans; cl17247 321967005259 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 321967005260 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 321967005261 citrate lyase subunit gamma; Provisional; Region: PRK13253 321967005262 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 321967005263 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 321967005264 active site 321967005265 nucleotide binding site [chemical binding]; other site 321967005266 HIGH motif; other site 321967005267 KMSKS motif; other site 321967005268 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 321967005269 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 321967005270 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 321967005271 carboxyltransferase (CT) interaction site; other site 321967005272 biotinylation site [posttranslational modification]; other site 321967005273 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 321967005274 Citrate transporter; Region: CitMHS; pfam03600 321967005275 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 321967005276 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 321967005277 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 321967005278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967005279 Coenzyme A binding pocket [chemical binding]; other site 321967005280 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 321967005281 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 321967005282 Predicted transcriptional regulators [Transcription]; Region: COG1695 321967005283 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 321967005284 Cytochrome C biogenesis protein; Region: CcmH; cl01179 321967005285 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 321967005286 dimer interface [polypeptide binding]; other site 321967005287 FMN binding site [chemical binding]; other site 321967005288 NADPH bind site [chemical binding]; other site 321967005289 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 321967005290 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 321967005291 Walker A/P-loop; other site 321967005292 ATP binding site [chemical binding]; other site 321967005293 Q-loop/lid; other site 321967005294 ABC transporter signature motif; other site 321967005295 Walker B; other site 321967005296 D-loop; other site 321967005297 H-loop/switch region; other site 321967005298 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 321967005299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 321967005300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 321967005301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967005302 Major Facilitator Superfamily; Region: MFS_1; pfam07690 321967005303 putative substrate translocation pore; other site 321967005304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967005305 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 321967005306 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 321967005307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967005308 non-specific DNA binding site [nucleotide binding]; other site 321967005309 salt bridge; other site 321967005310 sequence-specific DNA binding site [nucleotide binding]; other site 321967005311 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 321967005312 Predicted transcriptional regulators [Transcription]; Region: COG1725 321967005313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 321967005314 DNA-binding site [nucleotide binding]; DNA binding site 321967005315 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 321967005316 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967005317 Walker A/P-loop; other site 321967005318 ATP binding site [chemical binding]; other site 321967005319 Q-loop/lid; other site 321967005320 ABC transporter signature motif; other site 321967005321 Walker B; other site 321967005322 D-loop; other site 321967005323 H-loop/switch region; other site 321967005324 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 321967005325 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 321967005326 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 321967005327 Walker A/P-loop; other site 321967005328 ATP binding site [chemical binding]; other site 321967005329 Q-loop/lid; other site 321967005330 ABC transporter signature motif; other site 321967005331 Walker B; other site 321967005332 D-loop; other site 321967005333 H-loop/switch region; other site 321967005334 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 321967005335 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 321967005336 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 321967005337 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 321967005338 Walker A/P-loop; other site 321967005339 ATP binding site [chemical binding]; other site 321967005340 Q-loop/lid; other site 321967005341 ABC transporter signature motif; other site 321967005342 Walker B; other site 321967005343 D-loop; other site 321967005344 H-loop/switch region; other site 321967005345 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 321967005346 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 321967005347 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 321967005348 Walker A/P-loop; other site 321967005349 ATP binding site [chemical binding]; other site 321967005350 Q-loop/lid; other site 321967005351 ABC transporter signature motif; other site 321967005352 Walker B; other site 321967005353 D-loop; other site 321967005354 H-loop/switch region; other site 321967005355 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 321967005356 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 321967005357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967005358 dimer interface [polypeptide binding]; other site 321967005359 conserved gate region; other site 321967005360 putative PBP binding loops; other site 321967005361 ABC-ATPase subunit interface; other site 321967005362 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 321967005363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967005364 dimer interface [polypeptide binding]; other site 321967005365 conserved gate region; other site 321967005366 putative PBP binding loops; other site 321967005367 ABC-ATPase subunit interface; other site 321967005368 Winged helix-turn helix; Region: HTH_29; pfam13551 321967005369 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 321967005370 DNA-binding interface [nucleotide binding]; DNA binding site 321967005371 putative transposase OrfB; Reviewed; Region: PHA02517 321967005372 HTH-like domain; Region: HTH_21; pfam13276 321967005373 Integrase core domain; Region: rve; pfam00665 321967005374 Integrase core domain; Region: rve_2; pfam13333 321967005375 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 321967005376 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 321967005377 peptide binding site [polypeptide binding]; other site 321967005378 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 321967005379 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 321967005380 potential catalytic triad [active] 321967005381 conserved cys residue [active] 321967005382 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 321967005383 putative DNA binding site [nucleotide binding]; other site 321967005384 putative Zn2+ binding site [ion binding]; other site 321967005385 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 321967005386 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 321967005387 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 321967005388 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 321967005389 active site 321967005390 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 321967005391 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 321967005392 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 321967005393 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 321967005394 Transposase; Region: HTH_Tnp_1; pfam01527 321967005395 HTH-like domain; Region: HTH_21; pfam13276 321967005396 DDE domain; Region: DDE_Tnp_IS240; pfam13610 321967005397 Integrase core domain; Region: rve; pfam00665 321967005398 Integrase core domain; Region: rve_3; pfam13683 321967005399 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 321967005400 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 321967005401 active site 321967005402 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 321967005403 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 321967005404 Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890 321967005405 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 321967005406 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 321967005407 Phage tail protein; Region: Sipho_tail; pfam05709 321967005408 Phage tail protein; Region: Sipho_tail; cl17486 321967005409 Phage tail protein; Region: Sipho_tail; cl17486 321967005410 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967005411 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967005412 Integrase core domain; Region: rve; pfam00665 321967005413 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 321967005414 Phage-related protein [Function unknown]; Region: COG5412 321967005415 Phage protein; Region: DUF3647; pfam12363 321967005416 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 321967005417 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 321967005418 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 321967005419 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 321967005420 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 321967005421 Transposase; Region: HTH_Tnp_1; pfam01527 321967005422 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 321967005423 HTH-like domain; Region: HTH_21; pfam13276 321967005424 Integrase core domain; Region: rve; pfam00665 321967005425 Integrase core domain; Region: rve_3; cl15866 321967005426 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 321967005427 Minimal MMP-like domain found in Thermus thermophilus TTHA0227, Acidothermus cellulolyticus ACEL2062 and similar proteins; Region: MMP_TTHA0227_like; cl01577 321967005428 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 321967005429 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 321967005430 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 321967005431 Phage terminase large subunit; Region: Terminase_3; cl12054 321967005432 Terminase-like family; Region: Terminase_6; pfam03237 321967005433 Terminase small subunit; Region: Terminase_2; pfam03592 321967005434 GcrA cell cycle regulator; Region: GcrA; cl11564 321967005435 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 321967005436 active site 321967005437 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 321967005438 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967005439 non-specific DNA binding site [nucleotide binding]; other site 321967005440 salt bridge; other site 321967005441 sequence-specific DNA binding site [nucleotide binding]; other site 321967005442 YopX protein; Region: YopX; pfam09643 321967005443 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 321967005444 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 321967005445 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 321967005446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 321967005447 Walker A motif; other site 321967005448 ATP binding site [chemical binding]; other site 321967005449 Walker B motif; other site 321967005450 arginine finger; other site 321967005451 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 321967005452 Protein of unknown function (DUF669); Region: DUF669; pfam05037 321967005453 AAA domain; Region: AAA_25; pfam13481 321967005454 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352 321967005455 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 321967005456 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967005457 non-specific DNA binding site [nucleotide binding]; other site 321967005458 salt bridge; other site 321967005459 sequence-specific DNA binding site [nucleotide binding]; other site 321967005460 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967005461 non-specific DNA binding site [nucleotide binding]; other site 321967005462 salt bridge; other site 321967005463 sequence-specific DNA binding site [nucleotide binding]; other site 321967005464 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 321967005465 Catalytic site [active] 321967005466 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 321967005467 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 321967005468 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 321967005469 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 321967005470 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 321967005471 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 321967005472 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 321967005473 P-loop; other site 321967005474 Magnesium ion binding site [ion binding]; other site 321967005475 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 321967005476 Magnesium ion binding site [ion binding]; other site 321967005477 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 321967005478 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 321967005479 active site 321967005480 DNA binding site [nucleotide binding] 321967005481 Int/Topo IB signature motif; other site 321967005482 GMP synthase; Reviewed; Region: guaA; PRK00074 321967005483 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 321967005484 AMP/PPi binding site [chemical binding]; other site 321967005485 candidate oxyanion hole; other site 321967005486 catalytic triad [active] 321967005487 potential glutamine specificity residues [chemical binding]; other site 321967005488 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 321967005489 ATP Binding subdomain [chemical binding]; other site 321967005490 Dimerization subdomain; other site 321967005491 pantothenate kinase; Provisional; Region: PRK05439 321967005492 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 321967005493 ATP-binding site [chemical binding]; other site 321967005494 CoA-binding site [chemical binding]; other site 321967005495 Mg2+-binding site [ion binding]; other site 321967005496 Peptidase family C69; Region: Peptidase_C69; pfam03577 321967005497 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 321967005498 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 321967005499 Part of AAA domain; Region: AAA_19; pfam13245 321967005500 Family description; Region: UvrD_C_2; pfam13538 321967005501 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 321967005502 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 321967005503 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 321967005504 TrkA-C domain; Region: TrkA_C; pfam02080 321967005505 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 321967005506 manganese transport protein MntH; Reviewed; Region: PRK00701 321967005507 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 321967005508 Ferrochelatase; Region: Ferrochelatase; pfam00762 321967005509 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 321967005510 C-terminal domain interface [polypeptide binding]; other site 321967005511 active site 321967005512 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 321967005513 active site 321967005514 N-terminal domain interface [polypeptide binding]; other site 321967005515 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 321967005516 catalytic core [active] 321967005517 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 321967005518 FtsX-like permease family; Region: FtsX; pfam02687 321967005519 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 321967005520 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 321967005521 Walker A/P-loop; other site 321967005522 ATP binding site [chemical binding]; other site 321967005523 Q-loop/lid; other site 321967005524 ABC transporter signature motif; other site 321967005525 Walker B; other site 321967005526 D-loop; other site 321967005527 H-loop/switch region; other site 321967005528 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967005529 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967005530 Integrase core domain; Region: rve; pfam00665 321967005531 Amino acid permease; Region: AA_permease_2; pfam13520 321967005532 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 321967005533 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 321967005534 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 321967005535 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 321967005536 HflX GTPase family; Region: HflX; cd01878 321967005537 G1 box; other site 321967005538 GTP/Mg2+ binding site [chemical binding]; other site 321967005539 Switch I region; other site 321967005540 G2 box; other site 321967005541 G3 box; other site 321967005542 Switch II region; other site 321967005543 G4 box; other site 321967005544 G5 box; other site 321967005545 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 321967005546 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 321967005547 NodB motif; other site 321967005548 active site 321967005549 catalytic site [active] 321967005550 Zn binding site [ion binding]; other site 321967005551 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 321967005552 putative active site [active] 321967005553 conserved hypothetical integral membrane protein; Region: TIGR03766 321967005554 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 321967005555 Winged helix-turn helix; Region: HTH_29; pfam13551 321967005556 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 321967005557 DNA-binding interface [nucleotide binding]; DNA binding site 321967005558 putative transposase OrfB; Reviewed; Region: PHA02517 321967005559 HTH-like domain; Region: HTH_21; pfam13276 321967005560 Integrase core domain; Region: rve; pfam00665 321967005561 Integrase core domain; Region: rve_2; pfam13333 321967005562 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967005563 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967005564 Integrase core domain; Region: rve; pfam00665 321967005565 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967005566 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967005567 Integrase core domain; Region: rve; pfam00665 321967005568 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 321967005569 putative active site [active] 321967005570 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967005571 Integrase core domain; Region: rve; pfam00665 321967005572 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 321967005573 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 321967005574 NADP binding site [chemical binding]; other site 321967005575 active site 321967005576 putative substrate binding site [chemical binding]; other site 321967005577 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 321967005578 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 321967005579 NAD binding site [chemical binding]; other site 321967005580 substrate binding site [chemical binding]; other site 321967005581 homodimer interface [polypeptide binding]; other site 321967005582 active site 321967005583 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 321967005584 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 321967005585 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 321967005586 substrate binding site; other site 321967005587 tetramer interface; other site 321967005588 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 321967005589 Bacterial sugar transferase; Region: Bac_transf; pfam02397 321967005590 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 321967005591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 321967005592 NAD(P) binding site [chemical binding]; other site 321967005593 active site 321967005594 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 321967005595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967005596 dimer interface [polypeptide binding]; other site 321967005597 conserved gate region; other site 321967005598 putative PBP binding loops; other site 321967005599 ABC-ATPase subunit interface; other site 321967005600 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 321967005601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967005602 dimer interface [polypeptide binding]; other site 321967005603 conserved gate region; other site 321967005604 putative PBP binding loops; other site 321967005605 ABC-ATPase subunit interface; other site 321967005606 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 321967005607 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 321967005608 substrate binding pocket [chemical binding]; other site 321967005609 membrane-bound complex binding site; other site 321967005610 hinge residues; other site 321967005611 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 321967005612 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 321967005613 Walker A/P-loop; other site 321967005614 ATP binding site [chemical binding]; other site 321967005615 Q-loop/lid; other site 321967005616 ABC transporter signature motif; other site 321967005617 Walker B; other site 321967005618 D-loop; other site 321967005619 H-loop/switch region; other site 321967005620 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 321967005621 metal binding site 2 [ion binding]; metal-binding site 321967005622 putative DNA binding helix; other site 321967005623 metal binding site 1 [ion binding]; metal-binding site 321967005624 dimer interface [polypeptide binding]; other site 321967005625 structural Zn2+ binding site [ion binding]; other site 321967005626 Guanylate kinase; Region: Guanylate_kin; pfam00625 321967005627 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 321967005628 active site 321967005629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967005630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 321967005631 Coenzyme A binding pocket [chemical binding]; other site 321967005632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 321967005633 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 321967005634 NlpC/P60 family; Region: NLPC_P60; pfam00877 321967005635 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967005636 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967005637 Integrase core domain; Region: rve; pfam00665 321967005638 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 321967005639 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 321967005640 active site 321967005641 HIGH motif; other site 321967005642 dimer interface [polypeptide binding]; other site 321967005643 KMSKS motif; other site 321967005644 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 321967005645 RNA binding surface [nucleotide binding]; other site 321967005646 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 321967005647 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 321967005648 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 321967005649 dimerization interface [polypeptide binding]; other site 321967005650 putative DNA binding site [nucleotide binding]; other site 321967005651 putative Zn2+ binding site [ion binding]; other site 321967005652 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 321967005653 ApbE family; Region: ApbE; pfam02424 321967005654 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 321967005655 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 321967005656 active site 321967005657 homodimer interface [polypeptide binding]; other site 321967005658 catalytic site [active] 321967005659 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 321967005660 homodimer interface [polypeptide binding]; other site 321967005661 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 321967005662 active site pocket [active] 321967005663 glycogen synthase; Provisional; Region: glgA; PRK00654 321967005664 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 321967005665 ADP-binding pocket [chemical binding]; other site 321967005666 homodimer interface [polypeptide binding]; other site 321967005667 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 321967005668 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 321967005669 active site 321967005670 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 321967005671 dimer interface [polypeptide binding]; other site 321967005672 N-terminal domain interface [polypeptide binding]; other site 321967005673 sulfate 1 binding site; other site 321967005674 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 321967005675 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 321967005676 ligand binding site; other site 321967005677 oligomer interface; other site 321967005678 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 321967005679 dimer interface [polypeptide binding]; other site 321967005680 N-terminal domain interface [polypeptide binding]; other site 321967005681 sulfate 1 binding site; other site 321967005682 glycogen branching enzyme; Provisional; Region: PRK12313 321967005683 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 321967005684 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 321967005685 active site 321967005686 catalytic site [active] 321967005687 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 321967005688 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 321967005689 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 321967005690 homodimer interface [polypeptide binding]; other site 321967005691 substrate-cofactor binding pocket; other site 321967005692 catalytic residue [active] 321967005693 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 321967005694 Uncharacterized conserved protein [Function unknown]; Region: COG1284 321967005695 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 321967005696 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 321967005697 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 321967005698 ArsC family; Region: ArsC; pfam03960 321967005699 putative catalytic residues [active] 321967005700 thiol/disulfide switch; other site 321967005701 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967005702 Integrase core domain; Region: rve; pfam00665 321967005703 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 321967005704 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 321967005705 Walker A motif; other site 321967005706 ATP binding site [chemical binding]; other site 321967005707 Walker B motif; other site 321967005708 arginine finger; other site 321967005709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 321967005710 Walker A motif; other site 321967005711 ATP binding site [chemical binding]; other site 321967005712 Walker B motif; other site 321967005713 arginine finger; other site 321967005714 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 321967005715 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 321967005716 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 321967005717 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967005718 Integrase core domain; Region: rve; pfam00665 321967005719 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 321967005720 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 321967005721 NAD binding site [chemical binding]; other site 321967005722 substrate binding site [chemical binding]; other site 321967005723 homodimer interface [polypeptide binding]; other site 321967005724 active site 321967005725 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 321967005726 catalytic triad [active] 321967005727 catalytic triad [active] 321967005728 oxyanion hole [active] 321967005729 QueT transporter; Region: QueT; pfam06177 321967005730 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 321967005731 classical (c) SDRs; Region: SDR_c; cd05233 321967005732 NAD(P) binding site [chemical binding]; other site 321967005733 active site 321967005734 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 321967005735 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 321967005736 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967005737 non-specific DNA binding site [nucleotide binding]; other site 321967005738 salt bridge; other site 321967005739 sequence-specific DNA binding site [nucleotide binding]; other site 321967005740 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 321967005741 catalytic core [active] 321967005742 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 321967005743 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 321967005744 Walker A/P-loop; other site 321967005745 ATP binding site [chemical binding]; other site 321967005746 Q-loop/lid; other site 321967005747 ABC transporter signature motif; other site 321967005748 Walker B; other site 321967005749 D-loop; other site 321967005750 H-loop/switch region; other site 321967005751 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 321967005752 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 321967005753 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 321967005754 Walker A/P-loop; other site 321967005755 ATP binding site [chemical binding]; other site 321967005756 Q-loop/lid; other site 321967005757 ABC transporter signature motif; other site 321967005758 Walker B; other site 321967005759 D-loop; other site 321967005760 H-loop/switch region; other site 321967005761 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 321967005762 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 321967005763 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 321967005764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967005765 dimer interface [polypeptide binding]; other site 321967005766 conserved gate region; other site 321967005767 putative PBP binding loops; other site 321967005768 ABC-ATPase subunit interface; other site 321967005769 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 321967005770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967005771 dimer interface [polypeptide binding]; other site 321967005772 conserved gate region; other site 321967005773 putative PBP binding loops; other site 321967005774 ABC-ATPase subunit interface; other site 321967005775 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 321967005776 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 321967005777 peptide binding site [polypeptide binding]; other site 321967005778 elongation factor P; Validated; Region: PRK00529 321967005779 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 321967005780 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 321967005781 RNA binding site [nucleotide binding]; other site 321967005782 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 321967005783 RNA binding site [nucleotide binding]; other site 321967005784 Uncharacterized conserved protein [Function unknown]; Region: COG1556 321967005785 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 321967005786 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 321967005787 4Fe-4S binding domain; Region: Fer4; pfam00037 321967005788 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 321967005789 Cysteine-rich domain; Region: CCG; pfam02754 321967005790 Cysteine-rich domain; Region: CCG; pfam02754 321967005791 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 321967005792 active site 321967005793 methionine cluster; other site 321967005794 phosphorylation site [posttranslational modification] 321967005795 metal binding site [ion binding]; metal-binding site 321967005796 Uncharacterized conserved protein [Function unknown]; Region: COG3589 321967005797 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 321967005798 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 321967005799 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 321967005800 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 321967005801 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 321967005802 Melibiase; Region: Melibiase; pfam02065 321967005803 hypothetical protein; Validated; Region: PRK02101 321967005804 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 321967005805 DNA binding residues [nucleotide binding] 321967005806 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 321967005807 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 321967005808 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 321967005809 AAA domain; Region: AAA_30; pfam13604 321967005810 Family description; Region: UvrD_C_2; pfam13538 321967005811 WxL domain surface cell wall-binding; Region: WxL; pfam13731 321967005812 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 321967005813 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 321967005814 substrate binding site [chemical binding]; other site 321967005815 ATP binding site [chemical binding]; other site 321967005816 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 321967005817 Protein of unknown function DUF262; Region: DUF262; pfam03235 321967005818 Uncharacterized conserved protein [Function unknown]; Region: COG1479 321967005819 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 321967005820 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 321967005821 Int/Topo IB signature motif; other site 321967005822 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967005823 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967005824 Integrase core domain; Region: rve; pfam00665 321967005825 HsdM N-terminal domain; Region: HsdM_N; pfam12161 321967005826 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 321967005827 Methyltransferase domain; Region: Methyltransf_26; pfam13659 321967005828 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 321967005829 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 321967005830 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 321967005831 ATP binding site [chemical binding]; other site 321967005832 putative Mg++ binding site [ion binding]; other site 321967005833 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967005834 Integrase core domain; Region: rve; pfam00665 321967005835 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 321967005836 Protein of unknown function (DUF998); Region: DUF998; pfam06197 321967005837 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 321967005838 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 321967005839 active site turn [active] 321967005840 phosphorylation site [posttranslational modification] 321967005841 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 321967005842 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 321967005843 HPr interaction site; other site 321967005844 glycerol kinase (GK) interaction site [polypeptide binding]; other site 321967005845 active site 321967005846 phosphorylation site [posttranslational modification] 321967005847 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 321967005848 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 321967005849 Ca binding site [ion binding]; other site 321967005850 active site 321967005851 catalytic site [active] 321967005852 Transcriptional regulators [Transcription]; Region: PurR; COG1609 321967005853 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 321967005854 DNA binding site [nucleotide binding] 321967005855 domain linker motif; other site 321967005856 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 321967005857 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 321967005858 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 321967005859 substrate binding [chemical binding]; other site 321967005860 active site 321967005861 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 321967005862 similar to hypothetical protein 321967005863 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 321967005864 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 321967005865 NADP binding site [chemical binding]; other site 321967005866 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 321967005867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967005868 S-adenosylmethionine binding site [chemical binding]; other site 321967005869 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 321967005870 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 321967005871 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 321967005872 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 321967005873 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 321967005874 ATP-grasp domain; Region: ATP-grasp_4; cl17255 321967005875 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 321967005876 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 321967005877 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 321967005878 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 321967005879 carboxyltransferase (CT) interaction site; other site 321967005880 biotinylation site [posttranslational modification]; other site 321967005881 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 321967005882 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 321967005883 dimer interface [polypeptide binding]; other site 321967005884 active site 321967005885 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 321967005886 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 321967005887 NAD(P) binding site [chemical binding]; other site 321967005888 homotetramer interface [polypeptide binding]; other site 321967005889 homodimer interface [polypeptide binding]; other site 321967005890 active site 321967005891 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 321967005892 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 321967005893 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 321967005894 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 321967005895 FMN binding site [chemical binding]; other site 321967005896 substrate binding site [chemical binding]; other site 321967005897 putative catalytic residue [active] 321967005898 acyl carrier protein; Provisional; Region: acpP; PRK00982 321967005899 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 321967005900 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 321967005901 dimer interface [polypeptide binding]; other site 321967005902 active site 321967005903 CoA binding pocket [chemical binding]; other site 321967005904 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 321967005905 MarR family; Region: MarR_2; pfam12802 321967005906 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 321967005907 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 321967005908 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 321967005909 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 321967005910 dimer interface [polypeptide binding]; other site 321967005911 active site 321967005912 metal binding site [ion binding]; metal-binding site 321967005913 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 321967005914 Transcriptional regulators [Transcription]; Region: MarR; COG1846 321967005915 MarR family; Region: MarR_2; pfam12802 321967005916 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 321967005917 Putative esterase; Region: Esterase; pfam00756 321967005918 S-formylglutathione hydrolase; Region: PLN02442 321967005919 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 321967005920 Double zinc ribbon; Region: DZR; pfam12773 321967005921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 321967005922 putative DNA binding site [nucleotide binding]; other site 321967005923 putative Zn2+ binding site [ion binding]; other site 321967005924 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 321967005925 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 321967005926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967005927 Walker A/P-loop; other site 321967005928 ATP binding site [chemical binding]; other site 321967005929 Q-loop/lid; other site 321967005930 ABC transporter signature motif; other site 321967005931 Walker B; other site 321967005932 D-loop; other site 321967005933 H-loop/switch region; other site 321967005934 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 321967005935 nudix motif; other site 321967005936 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 321967005937 catalytic core [active] 321967005938 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 321967005939 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 321967005940 Double zinc ribbon; Region: DZR; pfam12773 321967005941 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 321967005942 Beta-lactamase; Region: Beta-lactamase; pfam00144 321967005943 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 321967005944 Domain of unknown function DUF20; Region: UPF0118; pfam01594 321967005945 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 321967005946 active site 321967005947 catalytic site [active] 321967005948 Predicted membrane protein [Function unknown]; Region: COG2246 321967005949 GtrA-like protein; Region: GtrA; pfam04138 321967005950 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 321967005951 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 321967005952 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 321967005953 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 321967005954 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 321967005955 PYR/PP interface [polypeptide binding]; other site 321967005956 dimer interface [polypeptide binding]; other site 321967005957 TPP binding site [chemical binding]; other site 321967005958 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 321967005959 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 321967005960 TPP-binding site [chemical binding]; other site 321967005961 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 321967005962 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 321967005963 Walker A/P-loop; other site 321967005964 ATP binding site [chemical binding]; other site 321967005965 Q-loop/lid; other site 321967005966 ABC transporter signature motif; other site 321967005967 Walker B; other site 321967005968 D-loop; other site 321967005969 H-loop/switch region; other site 321967005970 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 321967005971 DNA-binding protein, stimulates sugar fermentation [General function prediction only]; Region: SfsA; COG1489 321967005972 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 321967005973 Ligand Binding Site [chemical binding]; other site 321967005974 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 321967005975 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 321967005976 homoserine kinase; Provisional; Region: PRK01212 321967005977 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 321967005978 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 321967005979 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 321967005980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 321967005981 catalytic residue [active] 321967005982 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 321967005983 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 321967005984 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 321967005985 aspartate kinase; Reviewed; Region: PRK09034 321967005986 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 321967005987 putative catalytic residues [active] 321967005988 putative nucleotide binding site [chemical binding]; other site 321967005989 putative aspartate binding site [chemical binding]; other site 321967005990 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 321967005991 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 321967005992 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 321967005993 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 321967005994 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 321967005995 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 321967005996 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 321967005997 homodimer interface [polypeptide binding]; other site 321967005998 ligand binding site [chemical binding]; other site 321967005999 NAD binding site [chemical binding]; other site 321967006000 catalytic site [active] 321967006001 aromatic amino acid aminotransferase; Validated; Region: PRK07309 321967006002 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 321967006003 pyridoxal 5'-phosphate binding site [chemical binding]; other site 321967006004 homodimer interface [polypeptide binding]; other site 321967006005 catalytic residue [active] 321967006006 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 321967006007 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 321967006008 nucleotide binding site/active site [active] 321967006009 HIT family signature motif; other site 321967006010 catalytic residue [active] 321967006011 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 321967006012 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 321967006013 active site 321967006014 dimer interface [polypeptide binding]; other site 321967006015 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 321967006016 Ligand Binding Site [chemical binding]; other site 321967006017 Molecular Tunnel; other site 321967006018 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 321967006019 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 321967006020 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 321967006021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 321967006022 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 321967006023 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 321967006024 UbiA prenyltransferase family; Region: UbiA; pfam01040 321967006025 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 321967006026 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 321967006027 substrate binding pocket [chemical binding]; other site 321967006028 chain length determination region; other site 321967006029 substrate-Mg2+ binding site; other site 321967006030 catalytic residues [active] 321967006031 aspartate-rich region 1; other site 321967006032 active site lid residues [active] 321967006033 aspartate-rich region 2; other site 321967006034 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 321967006035 propionate/acetate kinase; Provisional; Region: PRK12379 321967006036 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 321967006037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967006038 Walker A/P-loop; other site 321967006039 ATP binding site [chemical binding]; other site 321967006040 Q-loop/lid; other site 321967006041 ABC transporter signature motif; other site 321967006042 Walker B; other site 321967006043 D-loop; other site 321967006044 H-loop/switch region; other site 321967006045 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 321967006046 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 321967006047 Predicted transcriptional regulators [Transcription]; Region: COG1725 321967006048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 321967006049 DNA-binding site [nucleotide binding]; DNA binding site 321967006050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967006051 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 321967006052 Walker A/P-loop; other site 321967006053 ATP binding site [chemical binding]; other site 321967006054 Q-loop/lid; other site 321967006055 ABC transporter signature motif; other site 321967006056 Walker B; other site 321967006057 D-loop; other site 321967006058 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967006059 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967006060 Integrase core domain; Region: rve; pfam00665 321967006061 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 321967006062 glucose-1-dehydrogenase; Provisional; Region: PRK08936 321967006063 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 321967006064 NAD binding site [chemical binding]; other site 321967006065 homodimer interface [polypeptide binding]; other site 321967006066 active site 321967006067 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967006068 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967006069 Integrase core domain; Region: rve; pfam00665 321967006070 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 321967006071 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 321967006072 hexamer interface [polypeptide binding]; other site 321967006073 ligand binding site [chemical binding]; other site 321967006074 putative active site [active] 321967006075 NAD(P) binding site [chemical binding]; other site 321967006076 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 321967006077 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 321967006078 tetramer interface [polypeptide binding]; other site 321967006079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 321967006080 catalytic residue [active] 321967006081 OPT oligopeptide transporter protein; Region: OPT; cl14607 321967006082 OPT oligopeptide transporter protein; Region: OPT; cl14607 321967006083 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 321967006084 Peptidase family C69; Region: Peptidase_C69; pfam03577 321967006085 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 321967006086 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 321967006087 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 321967006088 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 321967006089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967006090 Major Facilitator Superfamily; Region: MFS_1; pfam07690 321967006091 putative substrate translocation pore; other site 321967006092 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 321967006093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 321967006094 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967006095 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967006096 Homeodomain-like domain; Region: HTH_32; pfam13565 321967006097 Integrase core domain; Region: rve; pfam00665 321967006098 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 321967006099 beta-galactosidase; Region: BGL; TIGR03356 321967006100 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 321967006101 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 321967006102 active site turn [active] 321967006103 phosphorylation site [posttranslational modification] 321967006104 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 321967006105 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 321967006106 HPr interaction site; other site 321967006107 glycerol kinase (GK) interaction site [polypeptide binding]; other site 321967006108 active site 321967006109 phosphorylation site [posttranslational modification] 321967006110 transcriptional antiterminator BglG; Provisional; Region: PRK09772 321967006111 CAT RNA binding domain; Region: CAT_RBD; smart01061 321967006112 PRD domain; Region: PRD; pfam00874 321967006113 PRD domain; Region: PRD; pfam00874 321967006114 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 321967006115 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 321967006116 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 321967006117 Walker A/P-loop; other site 321967006118 ATP binding site [chemical binding]; other site 321967006119 Q-loop/lid; other site 321967006120 ABC transporter signature motif; other site 321967006121 Walker B; other site 321967006122 D-loop; other site 321967006123 H-loop/switch region; other site 321967006124 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 321967006125 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 321967006126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967006127 Walker A/P-loop; other site 321967006128 ATP binding site [chemical binding]; other site 321967006129 Q-loop/lid; other site 321967006130 ABC transporter signature motif; other site 321967006131 Walker B; other site 321967006132 D-loop; other site 321967006133 H-loop/switch region; other site 321967006134 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 321967006135 trimer interface [polypeptide binding]; other site 321967006136 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 321967006137 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 321967006138 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 321967006139 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 321967006140 Walker A/P-loop; other site 321967006141 ATP binding site [chemical binding]; other site 321967006142 Q-loop/lid; other site 321967006143 ABC transporter signature motif; other site 321967006144 Walker B; other site 321967006145 D-loop; other site 321967006146 H-loop/switch region; other site 321967006147 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 321967006148 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 321967006149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967006150 Walker A/P-loop; other site 321967006151 ATP binding site [chemical binding]; other site 321967006152 Q-loop/lid; other site 321967006153 ABC transporter signature motif; other site 321967006154 Walker B; other site 321967006155 D-loop; other site 321967006156 H-loop/switch region; other site 321967006157 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 321967006158 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 321967006159 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 321967006160 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 321967006161 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 321967006162 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 321967006163 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 321967006164 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 321967006165 adenosine deaminase; Provisional; Region: PRK09358 321967006166 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 321967006167 active site 321967006168 Protein of unknown function (DUF460); Region: DUF460; pfam04312 321967006169 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 321967006170 EamA-like transporter family; Region: EamA; pfam00892 321967006171 EamA-like transporter family; Region: EamA; pfam00892 321967006172 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 321967006173 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 321967006174 Ligand Binding Site [chemical binding]; other site 321967006175 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 321967006176 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967006177 non-specific DNA binding site [nucleotide binding]; other site 321967006178 salt bridge; other site 321967006179 sequence-specific DNA binding site [nucleotide binding]; other site 321967006180 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 321967006181 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 321967006182 epoxyqueuosine reductase; Region: TIGR00276 321967006183 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 321967006184 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 321967006185 protein binding surface [polypeptide binding]; other site 321967006186 HEAT repeats; Region: HEAT_2; pfam13646 321967006187 BioY family; Region: BioY; pfam02632 321967006188 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 321967006189 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 321967006190 DNA binding residues [nucleotide binding] 321967006191 putative dimer interface [polypeptide binding]; other site 321967006192 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 321967006193 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 321967006194 NADH(P)-binding; Region: NAD_binding_10; pfam13460 321967006195 putative NAD(P) binding site [chemical binding]; other site 321967006196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967006197 S-adenosylmethionine binding site [chemical binding]; other site 321967006198 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 321967006199 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 321967006200 catalytic triad [active] 321967006201 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 321967006202 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 321967006203 Domain of unknown function DUF21; Region: DUF21; pfam01595 321967006204 FOG: CBS domain [General function prediction only]; Region: COG0517 321967006205 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 321967006206 Transporter associated domain; Region: CorC_HlyC; smart01091 321967006207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967006208 Major Facilitator Superfamily; Region: MFS_1; pfam07690 321967006209 Maf-like protein; Region: Maf; pfam02545 321967006210 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 321967006211 active site 321967006212 dimer interface [polypeptide binding]; other site 321967006213 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 321967006214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 321967006215 ATP binding site [chemical binding]; other site 321967006216 Mg2+ binding site [ion binding]; other site 321967006217 G-X-G motif; other site 321967006218 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 321967006219 ATP binding site [chemical binding]; other site 321967006220 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 321967006221 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 321967006222 MutS domain I; Region: MutS_I; pfam01624 321967006223 MutS domain II; Region: MutS_II; pfam05188 321967006224 MutS domain III; Region: MutS_III; pfam05192 321967006225 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 321967006226 Walker A/P-loop; other site 321967006227 ATP binding site [chemical binding]; other site 321967006228 Q-loop/lid; other site 321967006229 ABC transporter signature motif; other site 321967006230 Walker B; other site 321967006231 D-loop; other site 321967006232 H-loop/switch region; other site 321967006233 Amino acid permease; Region: AA_permease_2; pfam13520 321967006234 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 321967006235 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 321967006236 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 321967006237 ring oligomerisation interface [polypeptide binding]; other site 321967006238 ATP/Mg binding site [chemical binding]; other site 321967006239 stacking interactions; other site 321967006240 hinge regions; other site 321967006241 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 321967006242 oligomerisation interface [polypeptide binding]; other site 321967006243 mobile loop; other site 321967006244 roof hairpin; other site 321967006245 CAAX protease self-immunity; Region: Abi; pfam02517 321967006246 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 321967006247 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 321967006248 DNA-binding site [nucleotide binding]; DNA binding site 321967006249 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 321967006250 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 321967006251 CoA binding domain; Region: CoA_binding; pfam02629 321967006252 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 321967006253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967006254 Walker A/P-loop; other site 321967006255 ATP binding site [chemical binding]; other site 321967006256 Q-loop/lid; other site 321967006257 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 321967006258 ABC transporter signature motif; other site 321967006259 Walker B; other site 321967006260 D-loop; other site 321967006261 ABC transporter; Region: ABC_tran_2; pfam12848 321967006262 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 321967006263 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 321967006264 active site 321967006265 P-loop; other site 321967006266 phosphorylation site [posttranslational modification] 321967006267 UGMP family protein; Validated; Region: PRK09604 321967006268 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 321967006269 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 321967006270 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 321967006271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967006272 Coenzyme A binding pocket [chemical binding]; other site 321967006273 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 321967006274 Glycoprotease family; Region: Peptidase_M22; pfam00814 321967006275 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 321967006276 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 321967006277 active site 321967006278 homotetramer interface [polypeptide binding]; other site 321967006279 homodimer interface [polypeptide binding]; other site 321967006280 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 321967006281 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 321967006282 active site 321967006283 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 321967006284 active site 2 [active] 321967006285 active site 1 [active] 321967006286 Predicted methyltransferases [General function prediction only]; Region: COG0313 321967006287 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 321967006288 putative SAM binding site [chemical binding]; other site 321967006289 putative homodimer interface [polypeptide binding]; other site 321967006290 Protein of unknown function (DUF972); Region: DUF972; pfam06156 321967006291 DNA polymerase III subunit delta'; Validated; Region: PRK08058 321967006292 DNA polymerase III subunit delta'; Validated; Region: PRK08485 321967006293 Protein of unknown function (DUF970); Region: DUF970; pfam06153 321967006294 thymidylate kinase; Validated; Region: tmk; PRK00698 321967006295 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 321967006296 TMP-binding site; other site 321967006297 ATP-binding site [chemical binding]; other site 321967006298 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 321967006299 recombination protein RecR; Reviewed; Region: recR; PRK00076 321967006300 RecR protein; Region: RecR; pfam02132 321967006301 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 321967006302 putative active site [active] 321967006303 putative metal-binding site [ion binding]; other site 321967006304 tetramer interface [polypeptide binding]; other site 321967006305 hypothetical protein; Validated; Region: PRK00153 321967006306 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 321967006307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 321967006308 Walker A motif; other site 321967006309 ATP binding site [chemical binding]; other site 321967006310 Walker B motif; other site 321967006311 arginine finger; other site 321967006312 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 321967006313 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 321967006314 nucleoside/Zn binding site; other site 321967006315 dimer interface [polypeptide binding]; other site 321967006316 catalytic motif [active] 321967006317 Methyltransferase domain; Region: Methyltransf_31; pfam13847 321967006318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967006319 S-adenosylmethionine binding site [chemical binding]; other site 321967006320 Predicted integral membrane protein [Function unknown]; Region: COG0392 321967006321 Uncharacterized conserved protein [Function unknown]; Region: COG2898 321967006322 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 321967006323 Transcriptional regulators [Transcription]; Region: PurR; COG1609 321967006324 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 321967006325 DNA binding site [nucleotide binding] 321967006326 domain linker motif; other site 321967006327 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 321967006328 putative dimerization interface [polypeptide binding]; other site 321967006329 putative ligand binding site [chemical binding]; other site 321967006330 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 321967006331 putative active site [active] 321967006332 catalytic triad [active] 321967006333 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 321967006334 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 321967006335 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 321967006336 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 321967006337 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 321967006338 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 321967006339 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 321967006340 core dimer interface [polypeptide binding]; other site 321967006341 peripheral dimer interface [polypeptide binding]; other site 321967006342 L10 interface [polypeptide binding]; other site 321967006343 L11 interface [polypeptide binding]; other site 321967006344 putative EF-Tu interaction site [polypeptide binding]; other site 321967006345 putative EF-G interaction site [polypeptide binding]; other site 321967006346 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 321967006347 23S rRNA interface [nucleotide binding]; other site 321967006348 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 321967006349 drug efflux system protein MdtG; Provisional; Region: PRK09874 321967006350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967006351 putative substrate translocation pore; other site 321967006352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967006353 putative substrate translocation pore; other site 321967006354 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 321967006355 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 321967006356 NAD(P) binding site [chemical binding]; other site 321967006357 catalytic residues [active] 321967006358 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 321967006359 mRNA/rRNA interface [nucleotide binding]; other site 321967006360 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 321967006361 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 321967006362 23S rRNA interface [nucleotide binding]; other site 321967006363 L7/L12 interface [polypeptide binding]; other site 321967006364 putative thiostrepton binding site; other site 321967006365 L25 interface [polypeptide binding]; other site 321967006366 magnesium-transporting ATPase; Provisional; Region: PRK15122 321967006367 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 321967006368 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 321967006369 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 321967006370 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967006371 motif II; other site 321967006372 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 321967006373 amidase; Provisional; Region: PRK06529 321967006374 Amidase; Region: Amidase; cl11426 321967006375 Domain of unknown function (DU1801); Region: DUF1801; cl17490 321967006376 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 321967006377 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 321967006378 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 321967006379 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 321967006380 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 321967006381 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 321967006382 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 321967006383 putative homodimer interface [polypeptide binding]; other site 321967006384 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 321967006385 heterodimer interface [polypeptide binding]; other site 321967006386 homodimer interface [polypeptide binding]; other site 321967006387 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 321967006388 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 321967006389 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 321967006390 UbiA prenyltransferase family; Region: UbiA; pfam01040 321967006391 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 321967006392 UbiA prenyltransferase family; Region: UbiA; pfam01040 321967006393 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 321967006394 ApbE family; Region: ApbE; pfam02424 321967006395 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 321967006396 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 321967006397 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 321967006398 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 321967006399 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 321967006400 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 321967006401 trimer interface [polypeptide binding]; other site 321967006402 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 321967006403 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 321967006404 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 321967006405 substrate binding pocket [chemical binding]; other site 321967006406 chain length determination region; other site 321967006407 substrate-Mg2+ binding site; other site 321967006408 catalytic residues [active] 321967006409 aspartate-rich region 1; other site 321967006410 active site lid residues [active] 321967006411 aspartate-rich region 2; other site 321967006412 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 321967006413 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 321967006414 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 321967006415 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 321967006416 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 321967006417 YacP-like NYN domain; Region: NYN_YacP; pfam05991 321967006418 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 321967006419 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 321967006420 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 321967006421 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 321967006422 active site 321967006423 metal binding site [ion binding]; metal-binding site 321967006424 dimerization interface [polypeptide binding]; other site 321967006425 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 321967006426 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 321967006427 active site 321967006428 HIGH motif; other site 321967006429 nucleotide binding site [chemical binding]; other site 321967006430 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 321967006431 KMSKS motif; other site 321967006432 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 321967006433 tRNA binding surface [nucleotide binding]; other site 321967006434 anticodon binding site; other site 321967006435 FAD binding domain; Region: FAD_binding_4; pfam01565 321967006436 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 321967006437 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 321967006438 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 321967006439 active site 321967006440 HIGH motif; other site 321967006441 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 321967006442 active site 321967006443 KMSKS motif; other site 321967006444 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 321967006445 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 321967006446 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 321967006447 tetramer (dimer of dimers) interface [polypeptide binding]; other site 321967006448 active site 321967006449 dimer interface [polypeptide binding]; other site 321967006450 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 321967006451 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 321967006452 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 321967006453 putative active site [active] 321967006454 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 321967006455 Predicted membrane protein [General function prediction only]; Region: COG4194 321967006456 Predicted transcriptional regulators [Transcription]; Region: COG1725 321967006457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 321967006458 DNA-binding site [nucleotide binding]; DNA binding site 321967006459 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 321967006460 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 321967006461 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 321967006462 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 321967006463 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 321967006464 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 321967006465 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 321967006466 Walker A/P-loop; other site 321967006467 ATP binding site [chemical binding]; other site 321967006468 Q-loop/lid; other site 321967006469 ABC transporter signature motif; other site 321967006470 Walker B; other site 321967006471 D-loop; other site 321967006472 H-loop/switch region; other site 321967006473 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 321967006474 putative active site [active] 321967006475 DNA repair protein RadA; Provisional; Region: PRK11823 321967006476 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 321967006477 Walker A motif/ATP binding site; other site 321967006478 ATP binding site [chemical binding]; other site 321967006479 Walker B motif; other site 321967006480 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 321967006481 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 321967006482 trimer interface [polypeptide binding]; other site 321967006483 active site 321967006484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967006485 Coenzyme A binding pocket [chemical binding]; other site 321967006486 Protein of unknown function (DUF805); Region: DUF805; pfam05656 321967006487 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 321967006488 trimer interface [polypeptide binding]; other site 321967006489 active site 321967006490 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 321967006491 trimer interface [polypeptide binding]; other site 321967006492 active site 321967006493 G bulge; other site 321967006494 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 321967006495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967006496 Walker A/P-loop; other site 321967006497 ATP binding site [chemical binding]; other site 321967006498 Q-loop/lid; other site 321967006499 ABC transporter signature motif; other site 321967006500 Walker B; other site 321967006501 D-loop; other site 321967006502 H-loop/switch region; other site 321967006503 K+ potassium transporter; Region: K_trans; pfam02705 321967006504 pyruvate phosphate dikinase; Provisional; Region: PRK09279 321967006505 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 321967006506 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 321967006507 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 321967006508 HTH domain; Region: HTH_11; pfam08279 321967006509 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 321967006510 FOG: CBS domain [General function prediction only]; Region: COG0517 321967006511 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 321967006512 catalytic core [active] 321967006513 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 321967006514 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 321967006515 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 321967006516 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 321967006517 teramer interface [polypeptide binding]; other site 321967006518 active site 321967006519 FMN binding site [chemical binding]; other site 321967006520 catalytic residues [active] 321967006521 CsbD-like; Region: CsbD; pfam05532 321967006522 phosphopentomutase; Provisional; Region: PRK05362 321967006523 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 321967006524 benzoate transport; Region: 2A0115; TIGR00895 321967006525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967006526 putative substrate translocation pore; other site 321967006527 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 321967006528 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 321967006529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 321967006530 Transposase; Region: HTH_Tnp_1; pfam01527 321967006531 DDE domain; Region: DDE_Tnp_IS240; pfam13610 321967006532 Integrase core domain; Region: rve; pfam00665 321967006533 Integrase core domain; Region: rve_3; pfam13683 321967006534 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967006535 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967006536 Integrase core domain; Region: rve; pfam00665 321967006537 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 321967006538 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967006539 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967006540 Integrase core domain; Region: rve; pfam00665 321967006541 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 321967006542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967006543 H+ Antiporter protein; Region: 2A0121; TIGR00900 321967006544 putative substrate translocation pore; other site 321967006545 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 321967006546 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 321967006547 putative catalytic cysteine [active] 321967006548 gamma-glutamyl kinase; Provisional; Region: PRK05429 321967006549 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 321967006550 nucleotide binding site [chemical binding]; other site 321967006551 homotetrameric interface [polypeptide binding]; other site 321967006552 putative phosphate binding site [ion binding]; other site 321967006553 putative allosteric binding site; other site 321967006554 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 321967006555 active site 321967006556 catalytic site [active] 321967006557 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 321967006558 Cna protein B-type domain; Region: Cna_B; pfam05738 321967006559 Cna protein B-type domain; Region: Cna_B; pfam05738 321967006560 Cna protein B-type domain; Region: Cna_B; pfam05738 321967006561 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 321967006562 Uncharacterized conserved protein [Function unknown]; Region: COG3410 321967006563 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 321967006564 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 321967006565 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967006566 non-specific DNA binding site [nucleotide binding]; other site 321967006567 salt bridge; other site 321967006568 sequence-specific DNA binding site [nucleotide binding]; other site 321967006569 Predicted transcriptional regulators [Transcription]; Region: COG1695 321967006570 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 321967006571 hypothetical protein; Validated; Region: PRK07668 321967006572 Enterocin A Immunity; Region: EntA_Immun; pfam08951 321967006573 Enterocin A Immunity; Region: EntA_Immun; pfam08951 321967006574 Enterocin A Immunity; Region: EntA_Immun; pfam08951 321967006575 Uncharacterized conserved protein [Function unknown]; Region: COG2966 321967006576 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 321967006577 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 321967006578 similar to hypothetical protein 321967006579 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 321967006580 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 321967006581 HlyD family secretion protein; Region: HlyD_3; pfam13437 321967006582 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 321967006583 putative active site [active] 321967006584 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 321967006585 Transposase domain (DUF772); Region: DUF772; pfam05598 321967006586 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967006587 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967006588 Integrase core domain; Region: rve; pfam00665 321967006589 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 321967006590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 321967006591 active site 321967006592 phosphorylation site [posttranslational modification] 321967006593 intermolecular recognition site; other site 321967006594 dimerization interface [polypeptide binding]; other site 321967006595 LytTr DNA-binding domain; Region: LytTR; pfam04397 321967006596 CAAX protease self-immunity; Region: Abi; pfam02517 321967006597 CAAX protease self-immunity; Region: Abi; pfam02517 321967006598 Enterocin A Immunity; Region: EntA_Immun; pfam08951 321967006599 maltose O-acetyltransferase; Provisional; Region: PRK10092 321967006600 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 321967006601 active site 321967006602 substrate binding site [chemical binding]; other site 321967006603 trimer interface [polypeptide binding]; other site 321967006604 CoA binding site [chemical binding]; other site 321967006605 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967006606 Integrase core domain; Region: rve; pfam00665 321967006607 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 321967006608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 321967006609 NAD(P) binding site [chemical binding]; other site 321967006610 active site 321967006611 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 321967006612 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 321967006613 putative active site [active] 321967006614 putative FMN binding site [chemical binding]; other site 321967006615 putative substrate binding site [chemical binding]; other site 321967006616 putative catalytic residue [active] 321967006617 fumarate hydratase; Reviewed; Region: fumC; PRK00485 321967006618 Class II fumarases; Region: Fumarase_classII; cd01362 321967006619 active site 321967006620 tetramer interface [polypeptide binding]; other site 321967006621 manganese transport protein MntH; Reviewed; Region: PRK00701 321967006622 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 321967006623 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 321967006624 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 321967006625 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 321967006626 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 321967006627 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967006628 motif II; other site 321967006629 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 321967006630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967006631 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 321967006632 putative substrate translocation pore; other site 321967006633 multicopper oxidase; Provisional; Region: PRK10965 321967006634 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 321967006635 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 321967006636 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 321967006637 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 321967006638 metal binding site [ion binding]; metal-binding site 321967006639 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 321967006640 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 321967006641 ABC-ATPase subunit interface; other site 321967006642 dimer interface [polypeptide binding]; other site 321967006643 putative PBP binding regions; other site 321967006644 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 321967006645 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 321967006646 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 321967006647 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 321967006648 NAD binding site [chemical binding]; other site 321967006649 catalytic residues [active] 321967006650 substrate binding site [chemical binding]; other site 321967006651 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 321967006652 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 321967006653 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 321967006654 metal binding site [ion binding]; metal-binding site 321967006655 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 321967006656 NADH(P)-binding; Region: NAD_binding_10; pfam13460 321967006657 putative NAD(P) binding site [chemical binding]; other site 321967006658 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 321967006659 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 321967006660 nudix motif; other site 321967006661 Collagen binding domain; Region: Collagen_bind; pfam05737 321967006662 Cna protein B-type domain; Region: Cna_B; pfam05738 321967006663 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 321967006664 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 321967006665 metal binding site [ion binding]; metal-binding site 321967006666 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 321967006667 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 321967006668 Enolase, N-terminal domain; Region: Enolase_N; pfam03952 321967006669 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 321967006670 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 321967006671 membrane-bound complex binding site; other site 321967006672 hinge residues; other site 321967006673 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 321967006674 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 321967006675 Walker A/P-loop; other site 321967006676 ATP binding site [chemical binding]; other site 321967006677 Q-loop/lid; other site 321967006678 ABC transporter signature motif; other site 321967006679 Walker B; other site 321967006680 D-loop; other site 321967006681 H-loop/switch region; other site 321967006682 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 321967006683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967006684 dimer interface [polypeptide binding]; other site 321967006685 conserved gate region; other site 321967006686 putative PBP binding loops; other site 321967006687 ABC-ATPase subunit interface; other site 321967006688 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 321967006689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967006690 dimer interface [polypeptide binding]; other site 321967006691 conserved gate region; other site 321967006692 putative PBP binding loops; other site 321967006693 ABC-ATPase subunit interface; other site 321967006694 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 321967006695 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 321967006696 substrate binding pocket [chemical binding]; other site 321967006697 membrane-bound complex binding site; other site 321967006698 hinge residues; other site 321967006699 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 321967006700 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 321967006701 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 321967006702 acyl-activating enzyme (AAE) consensus motif; other site 321967006703 acyl-activating enzyme (AAE) consensus motif; other site 321967006704 putative AMP binding site [chemical binding]; other site 321967006705 putative active site [active] 321967006706 putative CoA binding site [chemical binding]; other site 321967006707 Acyltransferase family; Region: Acyl_transf_3; pfam01757 321967006708 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 321967006709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967006710 Walker A/P-loop; other site 321967006711 ATP binding site [chemical binding]; other site 321967006712 Q-loop/lid; other site 321967006713 ABC transporter signature motif; other site 321967006714 Walker B; other site 321967006715 D-loop; other site 321967006716 H-loop/switch region; other site 321967006717 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 321967006718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967006719 putative PBP binding loops; other site 321967006720 dimer interface [polypeptide binding]; other site 321967006721 ABC-ATPase subunit interface; other site 321967006722 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 321967006723 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 321967006724 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 321967006725 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 321967006726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967006727 Walker A/P-loop; other site 321967006728 ATP binding site [chemical binding]; other site 321967006729 Q-loop/lid; other site 321967006730 ABC transporter signature motif; other site 321967006731 Walker B; other site 321967006732 D-loop; other site 321967006733 H-loop/switch region; other site 321967006734 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 321967006735 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 321967006736 Transposase; Region: DDE_Tnp_ISL3; pfam01610 321967006737 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 321967006738 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 321967006739 23S rRNA interface [nucleotide binding]; other site 321967006740 L3 interface [polypeptide binding]; other site 321967006741 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 321967006742 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 321967006743 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 321967006744 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 321967006745 Walker A/P-loop; other site 321967006746 ATP binding site [chemical binding]; other site 321967006747 Q-loop/lid; other site 321967006748 ABC transporter signature motif; other site 321967006749 Walker B; other site 321967006750 D-loop; other site 321967006751 H-loop/switch region; other site 321967006752 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 321967006753 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 321967006754 DNA binding residues [nucleotide binding] 321967006755 dimer interface [polypeptide binding]; other site 321967006756 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 321967006757 hypothetical protein; Validated; Region: PRK07668 321967006758 Predicted transcriptional regulators [Transcription]; Region: COG1695 321967006759 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 321967006760 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 321967006761 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 321967006762 dimerization interface 3.5A [polypeptide binding]; other site 321967006763 active site 321967006764 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 321967006765 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 321967006766 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 321967006767 Walker A/P-loop; other site 321967006768 ATP binding site [chemical binding]; other site 321967006769 Q-loop/lid; other site 321967006770 ABC transporter signature motif; other site 321967006771 Walker B; other site 321967006772 D-loop; other site 321967006773 H-loop/switch region; other site 321967006774 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 321967006775 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 321967006776 Walker A/P-loop; other site 321967006777 ATP binding site [chemical binding]; other site 321967006778 Q-loop/lid; other site 321967006779 ABC transporter signature motif; other site 321967006780 Walker B; other site 321967006781 D-loop; other site 321967006782 H-loop/switch region; other site 321967006783 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 321967006784 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 321967006785 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 321967006786 alphaNTD homodimer interface [polypeptide binding]; other site 321967006787 alphaNTD - beta interaction site [polypeptide binding]; other site 321967006788 alphaNTD - beta' interaction site [polypeptide binding]; other site 321967006789 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 321967006790 30S ribosomal protein S11; Validated; Region: PRK05309 321967006791 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 321967006792 30S ribosomal protein S13; Region: bact_S13; TIGR03631 321967006793 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 321967006794 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 321967006795 rRNA binding site [nucleotide binding]; other site 321967006796 predicted 30S ribosome binding site; other site 321967006797 adenylate kinase; Reviewed; Region: adk; PRK00279 321967006798 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 321967006799 AMP-binding site [chemical binding]; other site 321967006800 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 321967006801 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 321967006802 SecY translocase; Region: SecY; pfam00344 321967006803 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 321967006804 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 321967006805 23S rRNA binding site [nucleotide binding]; other site 321967006806 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 321967006807 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 321967006808 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 321967006809 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 321967006810 5S rRNA interface [nucleotide binding]; other site 321967006811 L27 interface [polypeptide binding]; other site 321967006812 23S rRNA interface [nucleotide binding]; other site 321967006813 L5 interface [polypeptide binding]; other site 321967006814 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 321967006815 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 321967006816 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 321967006817 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 321967006818 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 321967006819 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 321967006820 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 321967006821 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 321967006822 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 321967006823 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 321967006824 RNA binding site [nucleotide binding]; other site 321967006825 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 321967006826 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 321967006827 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 321967006828 23S rRNA interface [nucleotide binding]; other site 321967006829 putative translocon interaction site; other site 321967006830 signal recognition particle (SRP54) interaction site; other site 321967006831 L23 interface [polypeptide binding]; other site 321967006832 trigger factor interaction site; other site 321967006833 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 321967006834 23S rRNA interface [nucleotide binding]; other site 321967006835 5S rRNA interface [nucleotide binding]; other site 321967006836 putative antibiotic binding site [chemical binding]; other site 321967006837 L25 interface [polypeptide binding]; other site 321967006838 L27 interface [polypeptide binding]; other site 321967006839 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 321967006840 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 321967006841 G-X-X-G motif; other site 321967006842 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 321967006843 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 321967006844 putative translocon binding site; other site 321967006845 protein-rRNA interface [nucleotide binding]; other site 321967006846 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 321967006847 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 321967006848 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 321967006849 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 321967006850 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 321967006851 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 321967006852 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 321967006853 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 321967006854 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 321967006855 peroxiredoxin; Region: AhpC; TIGR03137 321967006856 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 321967006857 dimer interface [polypeptide binding]; other site 321967006858 decamer (pentamer of dimers) interface [polypeptide binding]; other site 321967006859 catalytic triad [active] 321967006860 peroxidatic and resolving cysteines [active] 321967006861 Predicted transcriptional regulator [Transcription]; Region: COG2378 321967006862 WYL domain; Region: WYL; pfam13280 321967006863 elongation factor G; Reviewed; Region: PRK12739 321967006864 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 321967006865 G1 box; other site 321967006866 putative GEF interaction site [polypeptide binding]; other site 321967006867 GTP/Mg2+ binding site [chemical binding]; other site 321967006868 Switch I region; other site 321967006869 G2 box; other site 321967006870 G3 box; other site 321967006871 Switch II region; other site 321967006872 G4 box; other site 321967006873 G5 box; other site 321967006874 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 321967006875 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 321967006876 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 321967006877 30S ribosomal protein S7; Validated; Region: PRK05302 321967006878 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 321967006879 S17 interaction site [polypeptide binding]; other site 321967006880 S8 interaction site; other site 321967006881 16S rRNA interaction site [nucleotide binding]; other site 321967006882 streptomycin interaction site [chemical binding]; other site 321967006883 23S rRNA interaction site [nucleotide binding]; other site 321967006884 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 321967006885 Cna protein B-type domain; Region: Cna_B; pfam05738 321967006886 Cna protein B-type domain; Region: Cna_B; pfam05738 321967006887 Cna protein B-type domain; Region: Cna_B; pfam05738 321967006888 Cna protein B-type domain; Region: Cna_B; pfam05738 321967006889 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 321967006890 Cna protein B-type domain; Region: Cna_B; pfam05738 321967006891 Cna protein B-type domain; Region: Cna_B; pfam05738 321967006892 Cna protein B-type domain; Region: Cna_B; pfam05738 321967006893 Cna protein B-type domain; Region: Cna_B; pfam05738 321967006894 Cna protein B-type domain; Region: Cna_B; pfam05738 321967006895 Cna protein B-type domain; Region: Cna_B; pfam05738 321967006896 Cna protein B-type domain; Region: Cna_B; pfam05738 321967006897 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967006898 Integrase core domain; Region: rve; pfam00665 321967006899 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 321967006900 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 321967006901 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 321967006902 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 321967006903 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 321967006904 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 321967006905 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 321967006906 DNA binding site [nucleotide binding] 321967006907 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 321967006908 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 321967006909 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 321967006910 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 321967006911 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 321967006912 RPB1 interaction site [polypeptide binding]; other site 321967006913 RPB10 interaction site [polypeptide binding]; other site 321967006914 RPB11 interaction site [polypeptide binding]; other site 321967006915 RPB3 interaction site [polypeptide binding]; other site 321967006916 RPB12 interaction site [polypeptide binding]; other site 321967006917 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 321967006918 Clp amino terminal domain; Region: Clp_N; pfam02861 321967006919 Clp amino terminal domain; Region: Clp_N; pfam02861 321967006920 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 321967006921 Walker A motif; other site 321967006922 ATP binding site [chemical binding]; other site 321967006923 Walker B motif; other site 321967006924 arginine finger; other site 321967006925 UvrB/uvrC motif; Region: UVR; pfam02151 321967006926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 321967006927 Walker A motif; other site 321967006928 ATP binding site [chemical binding]; other site 321967006929 Walker B motif; other site 321967006930 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 321967006931 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 321967006932 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 321967006933 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 321967006934 dimer interface [polypeptide binding]; other site 321967006935 putative anticodon binding site; other site 321967006936 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 321967006937 motif 1; other site 321967006938 active site 321967006939 motif 2; other site 321967006940 motif 3; other site 321967006941 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 321967006942 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 321967006943 FMN binding site [chemical binding]; other site 321967006944 active site 321967006945 catalytic residues [active] 321967006946 substrate binding site [chemical binding]; other site 321967006947 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 321967006948 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 321967006949 dimerization interface [polypeptide binding]; other site 321967006950 domain crossover interface; other site 321967006951 redox-dependent activation switch; other site 321967006952 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 321967006953 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 321967006954 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 321967006955 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 321967006956 legume lectins; Region: lectin_L-type; cl14058 321967006957 homotetramer interaction site [polypeptide binding]; other site 321967006958 homodimer interaction site [polypeptide binding]; other site 321967006959 carbohydrate binding site [chemical binding]; other site 321967006960 metal binding site [ion binding]; metal-binding site 321967006961 WxL domain surface cell wall-binding; Region: WxL; pfam13731 321967006962 FtsH Extracellular; Region: FtsH_ext; pfam06480 321967006963 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 321967006964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 321967006965 Walker A motif; other site 321967006966 ATP binding site [chemical binding]; other site 321967006967 Walker B motif; other site 321967006968 arginine finger; other site 321967006969 Peptidase family M41; Region: Peptidase_M41; pfam01434 321967006970 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 321967006971 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 321967006972 active site 321967006973 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 321967006974 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 321967006975 Ligand Binding Site [chemical binding]; other site 321967006976 TilS substrate C-terminal domain; Region: TilS_C; smart00977 321967006977 hypothetical protein; Provisional; Region: PRK08582 321967006978 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 321967006979 RNA binding site [nucleotide binding]; other site 321967006980 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 321967006981 Septum formation initiator; Region: DivIC; pfam04977 321967006982 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 321967006983 RNA binding surface [nucleotide binding]; other site 321967006984 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 321967006985 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 321967006986 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 321967006987 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 321967006988 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 321967006989 ATP binding site [chemical binding]; other site 321967006990 putative Mg++ binding site [ion binding]; other site 321967006991 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 321967006992 nucleotide binding region [chemical binding]; other site 321967006993 ATP-binding site [chemical binding]; other site 321967006994 TRCF domain; Region: TRCF; pfam03461 321967006995 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 321967006996 putative active site [active] 321967006997 catalytic residue [active] 321967006998 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 321967006999 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 321967007000 tetramer (dimer of dimers) interface [polypeptide binding]; other site 321967007001 NAD binding site [chemical binding]; other site 321967007002 dimer interface [polypeptide binding]; other site 321967007003 substrate binding site [chemical binding]; other site 321967007004 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 321967007005 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 321967007006 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 321967007007 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 321967007008 FOG: CBS domain [General function prediction only]; Region: COG0517 321967007009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 321967007010 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 321967007011 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 321967007012 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 321967007013 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 321967007014 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 321967007015 active site 321967007016 dimer interface [polypeptide binding]; other site 321967007017 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 321967007018 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 321967007019 active site 321967007020 FMN binding site [chemical binding]; other site 321967007021 substrate binding site [chemical binding]; other site 321967007022 3Fe-4S cluster binding site [ion binding]; other site 321967007023 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 321967007024 domain interface; other site 321967007025 QueT transporter; Region: QueT; pfam06177 321967007026 PemK-like protein; Region: PemK; pfam02452 321967007027 hypothetical protein; Region: PHA01623 321967007028 alanine racemase; Reviewed; Region: alr; PRK00053 321967007029 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 321967007030 active site 321967007031 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 321967007032 dimer interface [polypeptide binding]; other site 321967007033 substrate binding site [chemical binding]; other site 321967007034 catalytic residues [active] 321967007035 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 321967007036 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 321967007037 DEAD-like helicases superfamily; Region: DEXDc; smart00487 321967007038 ATP binding site [chemical binding]; other site 321967007039 Mg++ binding site [ion binding]; other site 321967007040 motif III; other site 321967007041 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 321967007042 nucleotide binding region [chemical binding]; other site 321967007043 ATP-binding site [chemical binding]; other site 321967007044 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 321967007045 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 321967007046 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 321967007047 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 321967007048 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 321967007049 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 321967007050 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 321967007051 hinge; other site 321967007052 active site 321967007053 CTP synthetase; Validated; Region: pyrG; PRK05380 321967007054 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 321967007055 Catalytic site [active] 321967007056 active site 321967007057 UTP binding site [chemical binding]; other site 321967007058 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 321967007059 active site 321967007060 putative oxyanion hole; other site 321967007061 catalytic triad [active] 321967007062 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 321967007063 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 321967007064 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 321967007065 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 321967007066 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 321967007067 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 321967007068 Zn2+ binding site [ion binding]; other site 321967007069 Mg2+ binding site [ion binding]; other site 321967007070 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 321967007071 nudix motif; other site 321967007072 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 321967007073 putative active site [active] 321967007074 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 321967007075 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 321967007076 hypothetical protein; Provisional; Region: PRK06446 321967007077 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 321967007078 metal binding site [ion binding]; metal-binding site 321967007079 dimer interface [polypeptide binding]; other site 321967007080 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 321967007081 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 321967007082 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 321967007083 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 321967007084 active site 321967007085 VanZ like family; Region: VanZ; pfam04892 321967007086 RDD family; Region: RDD; pfam06271 321967007087 pur operon repressor; Provisional; Region: PRK09213 321967007088 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 321967007089 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 321967007090 active site 321967007091 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 321967007092 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 321967007093 Walker A/P-loop; other site 321967007094 ATP binding site [chemical binding]; other site 321967007095 Q-loop/lid; other site 321967007096 ABC transporter signature motif; other site 321967007097 Walker B; other site 321967007098 D-loop; other site 321967007099 H-loop/switch region; other site 321967007100 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 321967007101 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 321967007102 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 321967007103 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 321967007104 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 321967007105 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 321967007106 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 321967007107 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 321967007108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967007109 S-adenosylmethionine binding site [chemical binding]; other site 321967007110 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 321967007111 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 321967007112 putative active site [active] 321967007113 putative metal binding site [ion binding]; other site 321967007114 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 321967007115 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 321967007116 active site 321967007117 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 321967007118 active site 321967007119 phosphorylation site [posttranslational modification] 321967007120 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 321967007121 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 321967007122 active site 321967007123 catalytic residues [active] 321967007124 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 321967007125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 321967007126 active site 321967007127 phosphorylation site [posttranslational modification] 321967007128 intermolecular recognition site; other site 321967007129 dimerization interface [polypeptide binding]; other site 321967007130 LytTr DNA-binding domain; Region: LytTR; smart00850 321967007131 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 321967007132 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 321967007133 ATP binding site [chemical binding]; other site 321967007134 Mg2+ binding site [ion binding]; other site 321967007135 G-X-G motif; other site 321967007136 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 321967007137 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967007138 Walker A/P-loop; other site 321967007139 ATP binding site [chemical binding]; other site 321967007140 Q-loop/lid; other site 321967007141 ABC transporter signature motif; other site 321967007142 Walker B; other site 321967007143 D-loop; other site 321967007144 H-loop/switch region; other site 321967007145 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 321967007146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967007147 Walker A/P-loop; other site 321967007148 ATP binding site [chemical binding]; other site 321967007149 Q-loop/lid; other site 321967007150 ABC transporter signature motif; other site 321967007151 Walker B; other site 321967007152 D-loop; other site 321967007153 H-loop/switch region; other site 321967007154 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 321967007155 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 321967007156 active site 321967007157 HIGH motif; other site 321967007158 KMSKS motif; other site 321967007159 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 321967007160 tRNA binding surface [nucleotide binding]; other site 321967007161 anticodon binding site; other site 321967007162 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 321967007163 dimer interface [polypeptide binding]; other site 321967007164 putative tRNA-binding site [nucleotide binding]; other site 321967007165 Protein of unknown function DUF72; Region: DUF72; pfam01904 321967007166 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 321967007167 putative active site [active] 321967007168 nucleotide binding site [chemical binding]; other site 321967007169 nudix motif; other site 321967007170 putative metal binding site [ion binding]; other site 321967007171 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 321967007172 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 321967007173 LDH/MDH dimer interface [polypeptide binding]; other site 321967007174 NAD(P) binding site [chemical binding]; other site 321967007175 substrate binding site [chemical binding]; other site 321967007176 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 321967007177 NAD-dependent deacetylase; Provisional; Region: PRK00481 321967007178 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 321967007179 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 321967007180 substrate binding site [chemical binding]; other site 321967007181 Predicted secreted protein [Function unknown]; Region: COG4086 321967007182 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 321967007183 exopolyphosphatase; Region: exo_poly_only; TIGR03706 321967007184 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 321967007185 polyphosphate kinase; Provisional; Region: PRK05443 321967007186 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 321967007187 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 321967007188 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 321967007189 putative domain interface [polypeptide binding]; other site 321967007190 putative active site [active] 321967007191 catalytic site [active] 321967007192 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 321967007193 putative domain interface [polypeptide binding]; other site 321967007194 putative active site [active] 321967007195 catalytic site [active] 321967007196 exopolyphosphatase; Region: exo_poly_only; TIGR03706 321967007197 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 321967007198 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 321967007199 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 321967007200 active site 321967007201 catalytic tetrad [active] 321967007202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 321967007203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 321967007204 S-adenosylmethionine binding site [chemical binding]; other site 321967007205 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 321967007206 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 321967007207 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 321967007208 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 321967007209 Repair protein; Region: Repair_PSII; pfam04536 321967007210 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 321967007211 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 321967007212 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 321967007213 active site 321967007214 HIGH motif; other site 321967007215 dimer interface [polypeptide binding]; other site 321967007216 KMSKS motif; other site 321967007217 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 321967007218 FtsX-like permease family; Region: FtsX; pfam02687 321967007219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967007220 Walker A/P-loop; other site 321967007221 ATP binding site [chemical binding]; other site 321967007222 ABC transporter; Region: ABC_tran; pfam00005 321967007223 Q-loop/lid; other site 321967007224 ABC transporter signature motif; other site 321967007225 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 321967007226 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 321967007227 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 321967007228 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 321967007229 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967007230 Walker A/P-loop; other site 321967007231 ATP binding site [chemical binding]; other site 321967007232 Q-loop/lid; other site 321967007233 ABC transporter signature motif; other site 321967007234 Walker B; other site 321967007235 D-loop; other site 321967007236 H-loop/switch region; other site 321967007237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967007238 conserved gate region; other site 321967007239 ABC-ATPase subunit interface; other site 321967007240 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 321967007241 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 321967007242 Part of AAA domain; Region: AAA_19; pfam13245 321967007243 Family description; Region: UvrD_C_2; pfam13538 321967007244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 321967007245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 321967007246 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 321967007247 dimerization interface [polypeptide binding]; other site 321967007248 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 321967007249 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 321967007250 gating phenylalanine in ion channel; other site 321967007251 CAAX protease self-immunity; Region: Abi; pfam02517 321967007252 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 321967007253 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 321967007254 Zn2+ binding site [ion binding]; other site 321967007255 Mg2+ binding site [ion binding]; other site 321967007256 Transcriptional regulators [Transcription]; Region: MarR; COG1846 321967007257 MarR family; Region: MarR_2; pfam12802 321967007258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967007259 Walker A/P-loop; other site 321967007260 ATP binding site [chemical binding]; other site 321967007261 Q-loop/lid; other site 321967007262 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 321967007263 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 321967007264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967007265 ABC transporter signature motif; other site 321967007266 Walker B; other site 321967007267 D-loop; other site 321967007268 H-loop/switch region; other site 321967007269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967007270 Walker A/P-loop; other site 321967007271 ATP binding site [chemical binding]; other site 321967007272 Q-loop/lid; other site 321967007273 ABC transporter signature motif; other site 321967007274 Walker B; other site 321967007275 D-loop; other site 321967007276 H-loop/switch region; other site 321967007277 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 321967007278 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 321967007279 active site 321967007280 catalytic tetrad [active] 321967007281 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 321967007282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967007283 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 321967007284 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 321967007285 catalytic core [active] 321967007286 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 321967007287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967007288 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 321967007289 active site 321967007290 motif I; other site 321967007291 motif II; other site 321967007292 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 321967007293 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 321967007294 RNA/DNA hybrid binding site [nucleotide binding]; other site 321967007295 active site 321967007296 Transcriptional regulator [Transcription]; Region: LysR; COG0583 321967007297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 321967007298 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 321967007299 dimerization interface [polypeptide binding]; other site 321967007300 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 321967007301 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 321967007302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 321967007303 homodimer interface [polypeptide binding]; other site 321967007304 catalytic residue [active] 321967007305 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 321967007306 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 321967007307 hexamer interface [polypeptide binding]; other site 321967007308 Walker A motif; other site 321967007309 ATP binding site [chemical binding]; other site 321967007310 Walker B motif; other site 321967007311 Protein of unknown function (DUF554); Region: DUF554; pfam04474 321967007312 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 321967007313 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 321967007314 active site 321967007315 P-loop; other site 321967007316 phosphorylation site [posttranslational modification] 321967007317 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 321967007318 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 321967007319 active site 321967007320 phosphorylation site [posttranslational modification] 321967007321 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 321967007322 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 321967007323 putative substrate binding site [chemical binding]; other site 321967007324 putative ATP binding site [chemical binding]; other site 321967007325 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 321967007326 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 321967007327 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 321967007328 putative active site [active] 321967007329 glycerol kinase; Provisional; Region: glpK; PRK00047 321967007330 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 321967007331 N- and C-terminal domain interface [polypeptide binding]; other site 321967007332 active site 321967007333 MgATP binding site [chemical binding]; other site 321967007334 catalytic site [active] 321967007335 metal binding site [ion binding]; metal-binding site 321967007336 glycerol binding site [chemical binding]; other site 321967007337 homotetramer interface [polypeptide binding]; other site 321967007338 homodimer interface [polypeptide binding]; other site 321967007339 FBP binding site [chemical binding]; other site 321967007340 protein IIAGlc interface [polypeptide binding]; other site 321967007341 Transposase; Region: DEDD_Tnp_IS110; pfam01548 321967007342 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 321967007343 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 321967007344 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 321967007345 Right handed beta helix region; Region: Beta_helix; pfam13229 321967007346 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 321967007347 Preprotein translocase subunit; Region: YajC; pfam02699 321967007348 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 321967007349 active pocket/dimerization site; other site 321967007350 active site 321967007351 phosphorylation site [posttranslational modification] 321967007352 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 321967007353 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 321967007354 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 321967007355 active site 321967007356 phosphorylation site [posttranslational modification] 321967007357 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 321967007358 Transcriptional regulator [Transcription]; Region: IclR; COG1414 321967007359 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 321967007360 Bacterial transcriptional regulator; Region: IclR; pfam01614 321967007361 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 321967007362 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 321967007363 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 321967007364 NADP binding site [chemical binding]; other site 321967007365 homodimer interface [polypeptide binding]; other site 321967007366 active site 321967007367 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 321967007368 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 321967007369 active site 321967007370 intersubunit interface [polypeptide binding]; other site 321967007371 catalytic residue [active] 321967007372 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 321967007373 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 321967007374 substrate binding site [chemical binding]; other site 321967007375 ATP binding site [chemical binding]; other site 321967007376 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 321967007377 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 321967007378 active site 321967007379 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 321967007380 tetramer (dimer of dimers) interface [polypeptide binding]; other site 321967007381 active site 321967007382 dimer interface [polypeptide binding]; other site 321967007383 conserved hypothetical integral membrane protein; Region: TIGR03766 321967007384 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 321967007385 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 321967007386 Ligand binding site; other site 321967007387 Putative Catalytic site; other site 321967007388 DXD motif; other site 321967007389 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 321967007390 active site 321967007391 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 321967007392 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 321967007393 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 321967007394 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 321967007395 HAMP domain; Region: HAMP; pfam00672 321967007396 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 321967007397 dimer interface [polypeptide binding]; other site 321967007398 phosphorylation site [posttranslational modification] 321967007399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 321967007400 ATP binding site [chemical binding]; other site 321967007401 Mg2+ binding site [ion binding]; other site 321967007402 G-X-G motif; other site 321967007403 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 321967007404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 321967007405 active site 321967007406 phosphorylation site [posttranslational modification] 321967007407 intermolecular recognition site; other site 321967007408 dimerization interface [polypeptide binding]; other site 321967007409 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 321967007410 DNA binding site [nucleotide binding] 321967007411 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 321967007412 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 321967007413 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 321967007414 NAD binding site [chemical binding]; other site 321967007415 sugar binding site [chemical binding]; other site 321967007416 divalent metal binding site [ion binding]; other site 321967007417 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 321967007418 dimer interface [polypeptide binding]; other site 321967007419 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706 321967007420 Polysaccharide lyase family 8, N terminal alpha-helical domain; Region: Lyase_8_N; pfam08124 321967007421 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967007422 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967007423 Integrase core domain; Region: rve; pfam00665 321967007424 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967007425 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967007426 Integrase core domain; Region: rve; pfam00665 321967007427 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 321967007428 HTH domain; Region: HTH_11; cl17392 321967007429 Mga helix-turn-helix domain; Region: Mga; pfam05043 321967007430 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967007431 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967007432 Integrase core domain; Region: rve; pfam00665 321967007433 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 321967007434 HPr interaction site; other site 321967007435 glycerol kinase (GK) interaction site [polypeptide binding]; other site 321967007436 active site 321967007437 phosphorylation site [posttranslational modification] 321967007438 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 321967007439 triosephosphate isomerase; Provisional; Region: PRK04302 321967007440 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 321967007441 intersubunit interface [polypeptide binding]; other site 321967007442 active site 321967007443 zinc binding site [ion binding]; other site 321967007444 Na+ binding site [ion binding]; other site 321967007445 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 321967007446 active site 321967007447 P-loop; other site 321967007448 phosphorylation site [posttranslational modification] 321967007449 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 321967007450 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 321967007451 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 321967007452 active site 321967007453 phosphorylation site [posttranslational modification] 321967007454 HTH domain; Region: HTH_11; cl17392 321967007455 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 321967007456 PRD domain; Region: PRD; pfam00874 321967007457 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 321967007458 active site 321967007459 P-loop; other site 321967007460 phosphorylation site [posttranslational modification] 321967007461 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 321967007462 Uncharacterized conserved protein [Function unknown]; Region: COG1434 321967007463 putative active site [active] 321967007464 Protein of unknown function (DUF1341); Region: DUF1341; pfam07071 321967007465 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 321967007466 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 321967007467 dihydroorotase; Provisional; Region: PRK09237 321967007468 active site 321967007469 Domain of unknown function (DUF4310); Region: DUF4310; pfam14187 321967007470 Domain of unknown function (DUF4311); Region: DUF4311; cl11919 321967007471 Domain of unknown function (DUF4312); Region: DUF4312; cl11917 321967007472 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 321967007473 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 321967007474 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 321967007475 HTH domain; Region: HTH_11; pfam08279 321967007476 HTH domain; Region: HTH_11; pfam08279 321967007477 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 321967007478 active site 321967007479 P-loop; other site 321967007480 phosphorylation site [posttranslational modification] 321967007481 Class I aldolases; Region: Aldolase_Class_I; cl17187 321967007482 catalytic residue [active] 321967007483 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 321967007484 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 321967007485 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 321967007486 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 321967007487 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 321967007488 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 321967007489 PRD domain; Region: PRD; pfam00874 321967007490 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 321967007491 active site 321967007492 phosphorylation site [posttranslational modification] 321967007493 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967007494 Integrase core domain; Region: rve; pfam00665 321967007495 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 321967007496 HTH domain; Region: HTH_11; pfam08279 321967007497 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 321967007498 classical (c) SDRs; Region: SDR_c; cd05233 321967007499 NAD(P) binding site [chemical binding]; other site 321967007500 active site 321967007501 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 321967007502 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 321967007503 intersubunit interface [polypeptide binding]; other site 321967007504 active site 321967007505 Zn2+ binding site [ion binding]; other site 321967007506 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967007507 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 321967007508 active site 321967007509 motif I; other site 321967007510 motif II; other site 321967007511 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967007512 motif II; other site 321967007513 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 321967007514 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 321967007515 AP (apurinic/apyrimidinic) site pocket; other site 321967007516 DNA interaction; other site 321967007517 Metal-binding active site; metal-binding site 321967007518 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 321967007519 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 321967007520 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 321967007521 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 321967007522 active site 321967007523 dimer interface [polypeptide binding]; other site 321967007524 magnesium binding site [ion binding]; other site 321967007525 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 321967007526 active site 321967007527 P-loop; other site 321967007528 phosphorylation site [posttranslational modification] 321967007529 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 321967007530 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 321967007531 active site 321967007532 phosphorylation site [posttranslational modification] 321967007533 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 321967007534 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 321967007535 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 321967007536 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 321967007537 active site 321967007538 phosphorylation site [posttranslational modification] 321967007539 Mga helix-turn-helix domain; Region: Mga; pfam05043 321967007540 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 321967007541 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 321967007542 nucleotide binding site [chemical binding]; other site 321967007543 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 321967007544 active site 321967007545 dimer interface [polypeptide binding]; other site 321967007546 catalytic nucleophile [active] 321967007547 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 321967007548 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 321967007549 active site 321967007550 metal binding site [ion binding]; metal-binding site 321967007551 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 321967007552 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 321967007553 DNA-binding site [nucleotide binding]; DNA binding site 321967007554 UTRA domain; Region: UTRA; pfam07702 321967007555 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 321967007556 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 321967007557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 321967007558 homodimer interface [polypeptide binding]; other site 321967007559 catalytic residue [active] 321967007560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967007561 Major Facilitator Superfamily; Region: MFS_1; pfam07690 321967007562 putative substrate translocation pore; other site 321967007563 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 321967007564 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 321967007565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967007566 Coenzyme A binding pocket [chemical binding]; other site 321967007567 Predicted transcriptional regulators [Transcription]; Region: COG1695 321967007568 Transcriptional regulator PadR-like family; Region: PadR; cl17335 321967007569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967007570 Major Facilitator Superfamily; Region: MFS_1; pfam07690 321967007571 putative substrate translocation pore; other site 321967007572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967007573 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967007574 Coenzyme A binding pocket [chemical binding]; other site 321967007575 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 321967007576 Isochorismatase family; Region: Isochorismatase; pfam00857 321967007577 catalytic triad [active] 321967007578 conserved cis-peptide bond; other site 321967007579 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 321967007580 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 321967007581 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967007582 non-specific DNA binding site [nucleotide binding]; other site 321967007583 salt bridge; other site 321967007584 sequence-specific DNA binding site [nucleotide binding]; other site 321967007585 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 321967007586 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 321967007587 active site 321967007588 catalytic site [active] 321967007589 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 321967007590 Low molecular weight phosphatase family; Region: LMWPc; cd00115 321967007591 active site 321967007592 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 321967007593 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 321967007594 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 321967007595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967007596 dimer interface [polypeptide binding]; other site 321967007597 conserved gate region; other site 321967007598 putative PBP binding loops; other site 321967007599 ABC-ATPase subunit interface; other site 321967007600 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 321967007601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967007602 dimer interface [polypeptide binding]; other site 321967007603 conserved gate region; other site 321967007604 putative PBP binding loops; other site 321967007605 ABC-ATPase subunit interface; other site 321967007606 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 321967007607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 321967007608 Walker A/P-loop; other site 321967007609 ATP binding site [chemical binding]; other site 321967007610 Q-loop/lid; other site 321967007611 ABC transporter signature motif; other site 321967007612 Walker B; other site 321967007613 D-loop; other site 321967007614 H-loop/switch region; other site 321967007615 TOBE domain; Region: TOBE_2; pfam08402 321967007616 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 321967007617 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 321967007618 active site 321967007619 Isochorismatase family; Region: Isochorismatase; pfam00857 321967007620 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 321967007621 catalytic triad [active] 321967007622 conserved cis-peptide bond; other site 321967007623 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 321967007624 nudix motif; other site 321967007625 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 321967007626 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 321967007627 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 321967007628 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 321967007629 active site 321967007630 catalytic site [active] 321967007631 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 321967007632 Cohesin domain, interaction partner of dockerin; Region: Type_III_cohesin_like; cd08759 321967007633 putative dockerin binding interface; other site 321967007634 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 321967007635 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 321967007636 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 321967007637 active site 321967007638 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 321967007639 Beta-lactamase; Region: Beta-lactamase; pfam00144 321967007640 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 321967007641 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 321967007642 putative active site [active] 321967007643 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 321967007644 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 321967007645 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 321967007646 putative active site [active] 321967007647 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 321967007648 active site 321967007649 phosphorylation site [posttranslational modification] 321967007650 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 321967007651 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 321967007652 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 321967007653 putative phosphate binding site [ion binding]; other site 321967007654 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 321967007655 DHH family; Region: DHH; pfam01368 321967007656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 321967007657 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 321967007658 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967007659 Coenzyme A binding pocket [chemical binding]; other site 321967007660 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 321967007661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967007662 Coenzyme A binding pocket [chemical binding]; other site 321967007663 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 321967007664 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967007665 active site 321967007666 motif I; other site 321967007667 motif II; other site 321967007668 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 321967007669 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 321967007670 putative NAD(P) binding site [chemical binding]; other site 321967007671 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 321967007672 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 321967007673 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 321967007674 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 321967007675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967007676 Coenzyme A binding pocket [chemical binding]; other site 321967007677 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 321967007678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967007679 Coenzyme A binding pocket [chemical binding]; other site 321967007680 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 321967007681 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 321967007682 Coenzyme A binding pocket [chemical binding]; other site 321967007683 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 321967007684 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 321967007685 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 321967007686 transmembrane helices; other site 321967007687 hypothetical protein; Provisional; Region: PRK06446 321967007688 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 321967007689 metal binding site [ion binding]; metal-binding site 321967007690 dimer interface [polypeptide binding]; other site 321967007691 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 321967007692 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 321967007693 peptide binding site [polypeptide binding]; other site 321967007694 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 321967007695 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 321967007696 Soluble P-type ATPase [General function prediction only]; Region: COG4087 321967007697 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 321967007698 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 321967007699 putative dimer interface [polypeptide binding]; other site 321967007700 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 321967007701 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 321967007702 protein binding site [polypeptide binding]; other site 321967007703 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 321967007704 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 321967007705 YycH protein; Region: YycI; pfam09648 321967007706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 321967007707 YycH protein; Region: YycH; pfam07435 321967007708 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 321967007709 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 321967007710 dimerization interface [polypeptide binding]; other site 321967007711 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 321967007712 putative active site [active] 321967007713 heme pocket [chemical binding]; other site 321967007714 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 321967007715 dimer interface [polypeptide binding]; other site 321967007716 phosphorylation site [posttranslational modification] 321967007717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 321967007718 ATP binding site [chemical binding]; other site 321967007719 Mg2+ binding site [ion binding]; other site 321967007720 G-X-G motif; other site 321967007721 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 321967007722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 321967007723 active site 321967007724 phosphorylation site [posttranslational modification] 321967007725 intermolecular recognition site; other site 321967007726 dimerization interface [polypeptide binding]; other site 321967007727 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 321967007728 DNA binding site [nucleotide binding] 321967007729 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 321967007730 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 321967007731 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 321967007732 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 321967007733 substrate binding pocket [chemical binding]; other site 321967007734 membrane-bound complex binding site; other site 321967007735 hinge residues; other site 321967007736 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 321967007737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967007738 dimer interface [polypeptide binding]; other site 321967007739 conserved gate region; other site 321967007740 putative PBP binding loops; other site 321967007741 ABC-ATPase subunit interface; other site 321967007742 argininosuccinate synthase; Provisional; Region: PRK13820 321967007743 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 321967007744 ANP binding site [chemical binding]; other site 321967007745 Substrate Binding Site II [chemical binding]; other site 321967007746 Substrate Binding Site I [chemical binding]; other site 321967007747 argininosuccinate lyase; Provisional; Region: PRK00855 321967007748 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 321967007749 active sites [active] 321967007750 tetramer interface [polypeptide binding]; other site 321967007751 Uncharacterized conserved protein [Function unknown]; Region: COG3589 321967007752 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 321967007753 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 321967007754 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 321967007755 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 321967007756 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 321967007757 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 321967007758 DNA-binding site [nucleotide binding]; DNA binding site 321967007759 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 321967007760 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 321967007761 active site 321967007762 P-loop; other site 321967007763 phosphorylation site [posttranslational modification] 321967007764 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 321967007765 active site 321967007766 methionine cluster; other site 321967007767 phosphorylation site [posttranslational modification] 321967007768 metal binding site [ion binding]; metal-binding site 321967007769 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 321967007770 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 321967007771 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 321967007772 nudix motif; other site 321967007773 Isochorismatase family; Region: Isochorismatase; pfam00857 321967007774 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 321967007775 catalytic triad [active] 321967007776 dimer interface [polypeptide binding]; other site 321967007777 conserved cis-peptide bond; other site 321967007778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967007779 Major Facilitator Superfamily; Region: MFS_1; pfam07690 321967007780 putative substrate translocation pore; other site 321967007781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967007782 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 321967007783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 321967007784 putative substrate translocation pore; other site 321967007785 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 321967007786 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 321967007787 active site 321967007788 catalytic tetrad [active] 321967007789 Domain of unknown function (DUF956); Region: DUF956; pfam06115 321967007790 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 321967007791 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 321967007792 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 321967007793 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 321967007794 active pocket/dimerization site; other site 321967007795 active site 321967007796 phosphorylation site [posttranslational modification] 321967007797 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 321967007798 active site 321967007799 phosphorylation site [posttranslational modification] 321967007800 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967007801 Integrase core domain; Region: rve; pfam00665 321967007802 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967007803 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 321967007804 non-specific DNA binding site [nucleotide binding]; other site 321967007805 salt bridge; other site 321967007806 sequence-specific DNA binding site [nucleotide binding]; other site 321967007807 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 321967007808 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 321967007809 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 321967007810 non-specific DNA binding site [nucleotide binding]; other site 321967007811 salt bridge; other site 321967007812 sequence-specific DNA binding site [nucleotide binding]; other site 321967007813 Helix-turn-helix domain; Region: HTH_19; pfam12844 321967007814 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 321967007815 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 321967007816 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 321967007817 substrate binding pocket [chemical binding]; other site 321967007818 membrane-bound complex binding site; other site 321967007819 hinge residues; other site 321967007820 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 321967007821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967007822 dimer interface [polypeptide binding]; other site 321967007823 conserved gate region; other site 321967007824 putative PBP binding loops; other site 321967007825 ABC-ATPase subunit interface; other site 321967007826 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 321967007827 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 321967007828 Walker A/P-loop; other site 321967007829 ATP binding site [chemical binding]; other site 321967007830 Q-loop/lid; other site 321967007831 ABC transporter signature motif; other site 321967007832 Walker B; other site 321967007833 D-loop; other site 321967007834 H-loop/switch region; other site 321967007835 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 321967007836 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 321967007837 Protein of unknown function (DUF975); Region: DUF975; cl10504 321967007838 Uncharacterized conserved protein [Function unknown]; Region: COG3402 321967007839 Predicted membrane protein [Function unknown]; Region: COG3428 321967007840 Bacterial PH domain; Region: DUF304; pfam03703 321967007841 Bacterial PH domain; Region: DUF304; pfam03703 321967007842 Bacterial PH domain; Region: DUF304; cl01348 321967007843 Predicted ATPase [General function prediction only]; Region: COG3910 321967007844 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 321967007845 Walker A/P-loop; other site 321967007846 ATP binding site [chemical binding]; other site 321967007847 Q-loop/lid; other site 321967007848 ABC transporter signature motif; other site 321967007849 Walker B; other site 321967007850 D-loop; other site 321967007851 H-loop/switch region; other site 321967007852 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 321967007853 Phosphotransferase enzyme family; Region: APH; pfam01636 321967007854 active site 321967007855 ATP binding site [chemical binding]; other site 321967007856 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 321967007857 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 321967007858 Walker A/P-loop; other site 321967007859 ATP binding site [chemical binding]; other site 321967007860 Q-loop/lid; other site 321967007861 ABC transporter signature motif; other site 321967007862 Walker B; other site 321967007863 D-loop; other site 321967007864 H-loop/switch region; other site 321967007865 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 321967007866 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 321967007867 substrate binding pocket [chemical binding]; other site 321967007868 membrane-bound complex binding site; other site 321967007869 hinge residues; other site 321967007870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967007871 dimer interface [polypeptide binding]; other site 321967007872 conserved gate region; other site 321967007873 putative PBP binding loops; other site 321967007874 ABC-ATPase subunit interface; other site 321967007875 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 321967007876 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 321967007877 substrate binding pocket [chemical binding]; other site 321967007878 membrane-bound complex binding site; other site 321967007879 hinge residues; other site 321967007880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 321967007881 dimer interface [polypeptide binding]; other site 321967007882 conserved gate region; other site 321967007883 putative PBP binding loops; other site 321967007884 ABC-ATPase subunit interface; other site 321967007885 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 321967007886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 321967007887 Integral membrane protein DUF95; Region: DUF95; pfam01944 321967007888 MoxR-like ATPases [General function prediction only]; Region: COG0714 321967007889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 321967007890 Walker A motif; other site 321967007891 ATP binding site [chemical binding]; other site 321967007892 Walker B motif; other site 321967007893 arginine finger; other site 321967007894 Protein of unknown function DUF58; Region: DUF58; pfam01882 321967007895 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 321967007896 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 321967007897 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967007898 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967007899 Integrase core domain; Region: rve; pfam00665 321967007900 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 321967007901 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 321967007902 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967007903 Helix-turn-helix domain; Region: HTH_38; pfam13936 321967007904 Integrase core domain; Region: rve; pfam00665 321967007905 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 321967007906 putative ADP-binding pocket [chemical binding]; other site 321967007907 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 321967007908 maltose O-acetyltransferase; Provisional; Region: PRK10092 321967007909 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 321967007910 active site 321967007911 substrate binding site [chemical binding]; other site 321967007912 trimer interface [polypeptide binding]; other site 321967007913 CoA binding site [chemical binding]; other site 321967007914 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967007915 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 321967007916 active site 321967007917 motif I; other site 321967007918 motif II; other site 321967007919 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967007920 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 321967007921 Aspartase; Region: Aspartase; cd01357 321967007922 active sites [active] 321967007923 tetramer interface [polypeptide binding]; other site 321967007924 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 321967007925 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 321967007926 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 321967007927 Malic enzyme, N-terminal domain; Region: malic; pfam00390 321967007928 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 321967007929 putative NAD(P) binding site [chemical binding]; other site 321967007930 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 321967007931 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 321967007932 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 321967007933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 321967007934 active site 321967007935 phosphorylation site [posttranslational modification] 321967007936 intermolecular recognition site; other site 321967007937 dimerization interface [polypeptide binding]; other site 321967007938 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 321967007939 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 321967007940 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 321967007941 amino acid transporter; Region: 2A0306; TIGR00909 321967007942 Agrin NtA domain; Region: NtA; pfam03146 321967007943 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 321967007944 Integrase core domain; Region: rve; pfam00665 321967007945 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 321967007946 Predicted membrane protein [Function unknown]; Region: COG2261 321967007947 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 321967007948 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 321967007949 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 321967007950 active site 321967007951 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 321967007952 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 321967007953 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 321967007954 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 321967007955 substrate binding pocket [chemical binding]; other site 321967007956 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 321967007957 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 321967007958 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 321967007959 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 321967007960 active site 321967007961 phosphorylation site [posttranslational modification] 321967007962 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 321967007963 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 321967007964 Mga helix-turn-helix domain; Region: Mga; pfam05043 321967007965 DNA-binding interface [nucleotide binding]; DNA binding site 321967007966 PRD domain; Region: PRD; pfam00874 321967007967 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 321967007968 active site 321967007969 P-loop; other site 321967007970 phosphorylation site [posttranslational modification] 321967007971 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 321967007972 active site 321967007973 phosphorylation site [posttranslational modification] 321967007974 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 321967007975 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 321967007976 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 321967007977 active site 321967007978 P-loop; other site 321967007979 phosphorylation site [posttranslational modification] 321967007980 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 321967007981 active site 321967007982 P-loop; other site 321967007983 phosphorylation site [posttranslational modification] 321967007984 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 321967007985 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 321967007986 active site 321967007987 trimer interface [polypeptide binding]; other site 321967007988 allosteric site; other site 321967007989 active site lid [active] 321967007990 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 321967007991 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 321967007992 active site 321967007993 motif I; other site 321967007994 motif II; other site 321967007995 HlyD family secretion protein; Region: HlyD_2; pfam12700 321967007996 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 321967007997 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 321967007998 Walker A/P-loop; other site 321967007999 ATP binding site [chemical binding]; other site 321967008000 Q-loop/lid; other site 321967008001 ABC transporter signature motif; other site 321967008002 Walker B; other site 321967008003 D-loop; other site 321967008004 H-loop/switch region; other site 321967008005 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 321967008006 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 321967008007 FtsX-like permease family; Region: FtsX; pfam02687 321967008008 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 321967008009 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 321967008010 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 321967008011 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 321967008012 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 321967008013 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 321967008014 putative active site [active] 321967008015 metal binding site [ion binding]; metal-binding site 321967008016 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 321967008017 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 321967008018 metal binding site [ion binding]; metal-binding site 321967008019 dimer interface [polypeptide binding]; other site 321967008020 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 321967008021 Uncharacterized conserved protein [Function unknown]; Region: COG2966 321967008022 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 321967008023 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 321967008024 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 321967008025 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 321967008026 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 321967008027 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 321967008028 trmE is a tRNA modification GTPase; Region: trmE; cd04164 321967008029 G1 box; other site 321967008030 GTP/Mg2+ binding site [chemical binding]; other site 321967008031 Switch I region; other site 321967008032 G2 box; other site 321967008033 Switch II region; other site 321967008034 G3 box; other site 321967008035 G4 box; other site 321967008036 G5 box; other site 321967008037 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 321967008038 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 321967008039 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 321967008040 G-X-X-G motif; other site 321967008041 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 321967008042 RxxxH motif; other site 321967008043 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 321967008044 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 321967008045 ribonuclease P; Reviewed; Region: rnpA; PRK00499 321967008046 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399