-- dump date 20140619_122614 -- class Genbank::misc_feature -- table misc_feature_note -- id note 511437000001 Transposase, Mutator family; Region: Transposase_mut; pfam00872 511437000002 MULE transposase domain; Region: MULE; pfam10551 511437000003 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 511437000004 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 511437000005 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 511437000006 catalytic residues [active] 511437000007 catalytic nucleophile [active] 511437000008 Presynaptic Site I dimer interface [polypeptide binding]; other site 511437000009 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 511437000010 Synaptic Flat tetramer interface [polypeptide binding]; other site 511437000011 Synaptic Site I dimer interface [polypeptide binding]; other site 511437000012 DNA binding site [nucleotide binding] 511437000013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511437000014 dimerization interface [polypeptide binding]; other site 511437000015 putative DNA binding site [nucleotide binding]; other site 511437000016 putative Zn2+ binding site [ion binding]; other site 511437000017 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 511437000018 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 511437000019 P loop; other site 511437000020 Nucleotide binding site [chemical binding]; other site 511437000021 DTAP/Switch II; other site 511437000022 Switch I; other site 511437000023 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 511437000024 DTAP/Switch II; other site 511437000025 Switch I; other site 511437000026 arsenical pump membrane protein; Provisional; Region: PRK15445 511437000027 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 511437000028 transmembrane helices; other site 511437000029 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 511437000030 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 511437000031 Low molecular weight phosphatase family; Region: LMWPc; cd00115 511437000032 active site 511437000033 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 511437000034 DNA topoisomerase III; Provisional; Region: PRK07726 511437000035 active site 511437000036 putative interdomain interaction site [polypeptide binding]; other site 511437000037 putative metal-binding site [ion binding]; other site 511437000038 putative nucleotide binding site [chemical binding]; other site 511437000039 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 511437000040 domain I; other site 511437000041 DNA binding groove [nucleotide binding] 511437000042 phosphate binding site [ion binding]; other site 511437000043 domain II; other site 511437000044 domain III; other site 511437000045 nucleotide binding site [chemical binding]; other site 511437000046 catalytic site [active] 511437000047 domain IV; other site 511437000048 MobA/MobL family; Region: MobA_MobL; pfam03389 511437000049 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 511437000050 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 511437000051 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 511437000052 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 511437000053 Magnesium ion binding site [ion binding]; other site 511437000054 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437000055 Helix-turn-helix domain; Region: HTH_38; pfam13936 511437000056 Integrase core domain; Region: rve; pfam00665 511437000057 Helix-turn-helix domain; Region: HTH_38; pfam13936 511437000058 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437000059 Integrase core domain; Region: rve; pfam00665 511437000060 Integrase core domain; Region: rve_3; cl15866 511437000061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511437000062 Transposase; Region: HTH_Tnp_1; pfam01527 511437000063 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 511437000064 ArsC family; Region: ArsC; pfam03960 511437000065 putative catalytic residues [active] 511437000066 thiol/disulfide switch; other site 511437000067 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437000068 Helix-turn-helix domain; Region: HTH_38; pfam13936 511437000069 Integrase core domain; Region: rve; pfam00665 511437000070 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 511437000071 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 511437000072 substrate binding site [chemical binding]; other site 511437000073 dimer interface [polypeptide binding]; other site 511437000074 ATP binding site [chemical binding]; other site 511437000075 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 511437000076 active site 511437000077 catalytic residues [active] 511437000078 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 511437000079 intersubunit interface [polypeptide binding]; other site 511437000080 active site 511437000081 catalytic residue [active] 511437000082 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 511437000083 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 511437000084 DNA binding residues [nucleotide binding] 511437000085 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 511437000086 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 511437000087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000088 putative substrate translocation pore; other site 511437000089 D-ribose pyranase; Provisional; Region: PRK11797 511437000090 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 511437000091 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 511437000092 substrate binding site [chemical binding]; other site 511437000093 dimer interface [polypeptide binding]; other site 511437000094 ATP binding site [chemical binding]; other site 511437000095 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 511437000096 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511437000097 active site 511437000098 dimer interface [polypeptide binding]; other site 511437000099 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 511437000100 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511437000101 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 511437000102 Core-2/I-Branching enzyme; Region: Branch; pfam02485 511437000103 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511437000104 active site 511437000105 HIGH motif; other site 511437000106 nucleotide binding site [chemical binding]; other site 511437000107 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 511437000108 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511437000109 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 511437000110 Transposase, Mutator family; Region: Transposase_mut; pfam00872 511437000111 MULE transposase domain; Region: MULE; pfam10551 511437000112 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 511437000113 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 511437000114 active site 511437000115 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511437000116 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 511437000117 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 511437000118 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 511437000119 active site 511437000120 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 511437000121 Bacterial sugar transferase; Region: Bac_transf; pfam02397 511437000122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000123 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 511437000124 NAD(P) binding site [chemical binding]; other site 511437000125 active site 511437000126 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 511437000127 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 511437000128 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 511437000129 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 511437000130 Chain length determinant protein; Region: Wzz; cl15801 511437000131 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 511437000132 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 511437000133 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 511437000134 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511437000135 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 511437000136 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 511437000137 Int/Topo IB signature motif; other site 511437000138 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 511437000139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 511437000140 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 511437000141 Low molecular weight phosphatase family; Region: LMWPc; cd00115 511437000142 active site 511437000143 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437000144 Helix-turn-helix domain; Region: HTH_38; pfam13936 511437000145 Integrase core domain; Region: rve; pfam00665 511437000146 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 511437000147 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511437000148 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 511437000149 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511437000150 dimerization interface [polypeptide binding]; other site 511437000151 putative DNA binding site [nucleotide binding]; other site 511437000152 putative Zn2+ binding site [ion binding]; other site 511437000153 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 511437000154 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 511437000155 DnaA N-terminal domain; Region: DnaA_N; pfam11638 511437000156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437000157 Walker A motif; other site 511437000158 ATP binding site [chemical binding]; other site 511437000159 Walker B motif; other site 511437000160 arginine finger; other site 511437000161 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 511437000162 DnaA box-binding interface [nucleotide binding]; other site 511437000163 DNA polymerase III subunit beta; Validated; Region: PRK05643 511437000164 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 511437000165 putative DNA binding surface [nucleotide binding]; other site 511437000166 dimer interface [polypeptide binding]; other site 511437000167 beta-clamp/clamp loader binding surface; other site 511437000168 beta-clamp/translesion DNA polymerase binding surface; other site 511437000169 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 511437000170 recombination protein F; Reviewed; Region: recF; PRK00064 511437000171 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 511437000172 Walker A/P-loop; other site 511437000173 ATP binding site [chemical binding]; other site 511437000174 Q-loop/lid; other site 511437000175 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437000176 ABC transporter signature motif; other site 511437000177 Walker B; other site 511437000178 D-loop; other site 511437000179 H-loop/switch region; other site 511437000180 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 511437000181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437000182 Mg2+ binding site [ion binding]; other site 511437000183 G-X-G motif; other site 511437000184 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 511437000185 anchoring element; other site 511437000186 dimer interface [polypeptide binding]; other site 511437000187 ATP binding site [chemical binding]; other site 511437000188 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 511437000189 active site 511437000190 putative metal-binding site [ion binding]; other site 511437000191 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 511437000192 DNA gyrase subunit A; Validated; Region: PRK05560 511437000193 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 511437000194 CAP-like domain; other site 511437000195 active site 511437000196 primary dimer interface [polypeptide binding]; other site 511437000197 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511437000198 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511437000199 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511437000200 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511437000201 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511437000202 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511437000203 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 511437000204 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 511437000205 active site 511437000206 teramer interface [polypeptide binding]; other site 511437000207 FMN binding site [chemical binding]; other site 511437000208 catalytic residues [active] 511437000209 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 511437000210 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 511437000211 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 511437000212 dimer interface [polypeptide binding]; other site 511437000213 ssDNA binding site [nucleotide binding]; other site 511437000214 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511437000215 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 511437000216 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 511437000217 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 511437000218 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 511437000219 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 511437000220 DHH family; Region: DHH; pfam01368 511437000221 DHHA1 domain; Region: DHHA1; pfam02272 511437000222 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 511437000223 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 511437000224 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 511437000225 replicative DNA helicase; Provisional; Region: PRK05748 511437000226 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 511437000227 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 511437000228 Walker A motif; other site 511437000229 ATP binding site [chemical binding]; other site 511437000230 Walker B motif; other site 511437000231 DNA binding loops [nucleotide binding] 511437000232 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 511437000233 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511437000234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511437000235 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 511437000236 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 511437000237 Int/Topo IB signature motif; other site 511437000238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437000239 non-specific DNA binding site [nucleotide binding]; other site 511437000240 salt bridge; other site 511437000241 sequence-specific DNA binding site [nucleotide binding]; other site 511437000242 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 511437000243 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 511437000244 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 511437000245 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 511437000246 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511437000247 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 511437000248 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 511437000249 polymerase nucleotide-binding site; other site 511437000250 DNA-binding residues [nucleotide binding]; DNA binding site 511437000251 nucleotide binding site [chemical binding]; other site 511437000252 primase nucleotide-binding site [nucleotide binding]; other site 511437000253 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 511437000254 D5 N terminal like; Region: D5_N; smart00885 511437000255 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 511437000256 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 511437000257 HTH domain; Region: HTH_11; cl17392 511437000258 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 511437000259 Integrase core domain; Region: rve; pfam00665 511437000260 DDE domain; Region: DDE_Tnp_IS240; pfam13610 511437000261 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437000262 Helix-turn-helix domain; Region: HTH_38; pfam13936 511437000263 Integrase core domain; Region: rve; pfam00665 511437000264 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 511437000265 homodimer interface [polypeptide binding]; other site 511437000266 chemical substrate binding site [chemical binding]; other site 511437000267 oligomer interface [polypeptide binding]; other site 511437000268 metal binding site [ion binding]; metal-binding site 511437000269 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 511437000270 GIY-YIG motif/motif A; other site 511437000271 putative active site [active] 511437000272 putative metal binding site [ion binding]; other site 511437000273 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 511437000274 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 511437000275 Walker A motif; other site 511437000276 ATP binding site [chemical binding]; other site 511437000277 Uncharacterized conserved protein [Function unknown]; Region: COG3410 511437000278 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437000279 Helix-turn-helix domain; Region: HTH_38; pfam13936 511437000280 Integrase core domain; Region: rve; pfam00665 511437000281 conserved hypothetical protein; Region: TIGR02328 511437000282 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 511437000283 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 511437000284 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 511437000285 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511437000286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511437000287 active site 511437000288 phosphorylation site [posttranslational modification] 511437000289 intermolecular recognition site; other site 511437000290 dimerization interface [polypeptide binding]; other site 511437000291 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511437000292 DNA binding site [nucleotide binding] 511437000293 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 511437000294 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511437000295 dimerization interface [polypeptide binding]; other site 511437000296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511437000297 putative active site [active] 511437000298 heme pocket [chemical binding]; other site 511437000299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511437000300 dimer interface [polypeptide binding]; other site 511437000301 phosphorylation site [posttranslational modification] 511437000302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437000303 ATP binding site [chemical binding]; other site 511437000304 Mg2+ binding site [ion binding]; other site 511437000305 G-X-G motif; other site 511437000306 YycH protein; Region: YycH; pfam07435 511437000307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 511437000308 YycH protein; Region: YycI; pfam09648 511437000309 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 511437000310 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 511437000311 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 511437000312 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 511437000313 protein binding site [polypeptide binding]; other site 511437000314 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 511437000315 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 511437000316 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 511437000317 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511437000318 MarR family; Region: MarR_2; pfam12802 511437000319 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 511437000320 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 511437000321 putative ligand binding site [chemical binding]; other site 511437000322 putative NAD binding site [chemical binding]; other site 511437000323 catalytic site [active] 511437000324 Predicted transcriptional regulators [Transcription]; Region: COG1733 511437000325 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 511437000326 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 511437000327 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 511437000328 classical (c) SDRs; Region: SDR_c; cd05233 511437000329 NAD(P) binding site [chemical binding]; other site 511437000330 active site 511437000331 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 511437000332 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 511437000333 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511437000334 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511437000335 peptide binding site [polypeptide binding]; other site 511437000336 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 511437000337 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 511437000338 oligomer interface [polypeptide binding]; other site 511437000339 active site 511437000340 metal binding site [ion binding]; metal-binding site 511437000341 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 511437000342 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 511437000343 catalytic triad [active] 511437000344 putative alpha-glucosidase; Provisional; Region: PRK10658 511437000345 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 511437000346 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 511437000347 trimer interface [polypeptide binding]; other site 511437000348 active site 511437000349 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 511437000350 catalytic site [active] 511437000351 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 511437000352 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 511437000353 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 511437000354 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 511437000355 formate dehydrogenase; Provisional; Region: PRK07574 511437000356 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 511437000357 NAD binding site [chemical binding]; other site 511437000358 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 511437000359 acetolactate synthase; Reviewed; Region: PRK08617 511437000360 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 511437000361 PYR/PP interface [polypeptide binding]; other site 511437000362 dimer interface [polypeptide binding]; other site 511437000363 TPP binding site [chemical binding]; other site 511437000364 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 511437000365 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 511437000366 TPP-binding site [chemical binding]; other site 511437000367 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511437000368 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 511437000369 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 511437000370 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 511437000371 tetrameric interface [polypeptide binding]; other site 511437000372 activator binding site; other site 511437000373 NADP binding site [chemical binding]; other site 511437000374 substrate binding site [chemical binding]; other site 511437000375 catalytic residues [active] 511437000376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000377 acetoin reductases; Region: 23BDH; TIGR02415 511437000378 NAD(P) binding site [chemical binding]; other site 511437000379 active site 511437000380 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 511437000381 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 511437000382 Transcriptional regulator [Transcription]; Region: IclR; COG1414 511437000383 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 511437000384 Bacterial transcriptional regulator; Region: IclR; pfam01614 511437000385 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 511437000386 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 511437000387 NADP binding site [chemical binding]; other site 511437000388 homodimer interface [polypeptide binding]; other site 511437000389 active site 511437000390 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 511437000391 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 511437000392 substrate binding site [chemical binding]; other site 511437000393 ATP binding site [chemical binding]; other site 511437000394 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 511437000395 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 511437000396 active site 511437000397 intersubunit interface [polypeptide binding]; other site 511437000398 catalytic residue [active] 511437000399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437000400 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437000401 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 511437000402 peptidase domain interface [polypeptide binding]; other site 511437000403 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 511437000404 active site 511437000405 catalytic residues [active] 511437000406 SH3-like domain; Region: SH3_8; pfam13457 511437000407 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 511437000408 Beta-lactamase; Region: Beta-lactamase; pfam00144 511437000409 Beta-lactamase; Region: Beta-lactamase; pfam00144 511437000410 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 511437000411 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 511437000412 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 511437000413 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 511437000414 acyl-activating enzyme (AAE) consensus motif; other site 511437000415 AMP binding site [chemical binding]; other site 511437000416 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 511437000417 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 511437000418 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 511437000419 DltD N-terminal region; Region: DltD_N; pfam04915 511437000420 DltD central region; Region: DltD_M; pfam04918 511437000421 DltD C-terminal region; Region: DltD_C; pfam04914 511437000422 SH3-like domain; Region: SH3_8; pfam13457 511437000423 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 511437000424 Beta-lactamase; Region: Beta-lactamase; pfam00144 511437000425 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511437000426 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 511437000427 Walker A/P-loop; other site 511437000428 ATP binding site [chemical binding]; other site 511437000429 Q-loop/lid; other site 511437000430 ABC transporter signature motif; other site 511437000431 Walker B; other site 511437000432 D-loop; other site 511437000433 H-loop/switch region; other site 511437000434 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 511437000435 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 511437000436 NADP binding site [chemical binding]; other site 511437000437 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 511437000438 CrcB-like protein; Region: CRCB; cl09114 511437000439 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 511437000440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511437000441 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 511437000442 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 511437000443 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 511437000444 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511437000445 catalytic residue [active] 511437000446 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 511437000447 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511437000448 HIGH motif; other site 511437000449 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511437000450 active site 511437000451 KMSKS motif; other site 511437000452 hypothetical protein; Provisional; Region: PRK13690 511437000453 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 511437000454 Predicted membrane protein [Function unknown]; Region: COG1288 511437000455 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 511437000456 OsmC-like protein; Region: OsmC; pfam02566 511437000457 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511437000458 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511437000459 peptide binding site [polypeptide binding]; other site 511437000460 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 511437000461 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 511437000462 Ca binding site [ion binding]; other site 511437000463 active site 511437000464 catalytic site [active] 511437000465 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 511437000466 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437000467 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 511437000468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000469 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511437000470 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437000471 DNA binding site [nucleotide binding] 511437000472 domain linker motif; other site 511437000473 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 511437000474 dimerization interface [polypeptide binding]; other site 511437000475 ligand binding site [chemical binding]; other site 511437000476 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 511437000477 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 511437000478 catalytic Zn binding site [ion binding]; other site 511437000479 NAD binding site [chemical binding]; other site 511437000480 structural Zn binding site [ion binding]; other site 511437000481 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 511437000482 putative uracil binding site [chemical binding]; other site 511437000483 putative active site [active] 511437000484 Low molecular weight phosphatase family; Region: LMWPc; cd00115 511437000485 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 511437000486 active site 511437000487 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 511437000488 active site 511437000489 dimerization interface [polypeptide binding]; other site 511437000490 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 511437000491 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 511437000492 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 511437000493 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 511437000494 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 511437000495 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 511437000496 active site 511437000497 catalytic site [active] 511437000498 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 511437000499 peptidase domain interface [polypeptide binding]; other site 511437000500 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 511437000501 active site 511437000502 catalytic triad [active] 511437000503 calcium binding site [ion binding]; other site 511437000504 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437000505 sequence-specific DNA binding site [nucleotide binding]; other site 511437000506 salt bridge; other site 511437000507 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 511437000508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437000509 Walker A/P-loop; other site 511437000510 ATP binding site [chemical binding]; other site 511437000511 Q-loop/lid; other site 511437000512 ABC transporter signature motif; other site 511437000513 Walker B; other site 511437000514 D-loop; other site 511437000515 H-loop/switch region; other site 511437000516 TOBE domain; Region: TOBE_2; pfam08402 511437000517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437000518 dimer interface [polypeptide binding]; other site 511437000519 conserved gate region; other site 511437000520 putative PBP binding loops; other site 511437000521 ABC-ATPase subunit interface; other site 511437000522 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 511437000523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437000524 dimer interface [polypeptide binding]; other site 511437000525 conserved gate region; other site 511437000526 putative PBP binding loops; other site 511437000527 ABC-ATPase subunit interface; other site 511437000528 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 511437000529 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 511437000530 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 511437000531 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 511437000532 active site 511437000533 catalytic site [active] 511437000534 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511437000535 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511437000536 peptide binding site [polypeptide binding]; other site 511437000537 Ferrochelatase; Region: Ferrochelatase; pfam00762 511437000538 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 511437000539 C-terminal domain interface [polypeptide binding]; other site 511437000540 active site 511437000541 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 511437000542 active site 511437000543 N-terminal domain interface [polypeptide binding]; other site 511437000544 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 511437000545 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 511437000546 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 511437000547 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 511437000548 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 511437000549 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 511437000550 CAAX protease self-immunity; Region: Abi; pfam02517 511437000551 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 511437000552 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 511437000553 DNA binding residues [nucleotide binding] 511437000554 putative dimer interface [polypeptide binding]; other site 511437000555 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437000556 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437000557 active site 511437000558 catalytic tetrad [active] 511437000559 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 511437000560 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 511437000561 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 511437000562 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 511437000563 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511437000564 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511437000565 DNA binding residues [nucleotide binding] 511437000566 Phosphotransferase enzyme family; Region: APH; pfam01636 511437000567 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 511437000568 active site 511437000569 ATP binding site [chemical binding]; other site 511437000570 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 511437000571 substrate binding site [chemical binding]; other site 511437000572 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 511437000573 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 511437000574 putative active site [active] 511437000575 putative FMN binding site [chemical binding]; other site 511437000576 putative substrate binding site [chemical binding]; other site 511437000577 putative catalytic residue [active] 511437000578 L-aspartate oxidase; Provisional; Region: PRK06175 511437000579 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 511437000580 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 511437000581 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437000582 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437000583 active site 511437000584 catalytic tetrad [active] 511437000585 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 511437000586 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 511437000587 dimerization interface [polypeptide binding]; other site 511437000588 DPS ferroxidase diiron center [ion binding]; other site 511437000589 ion pore; other site 511437000590 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 511437000591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000592 putative substrate translocation pore; other site 511437000593 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 511437000594 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437000595 active site 511437000596 motif I; other site 511437000597 motif II; other site 511437000598 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 511437000599 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 511437000600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000601 putative substrate translocation pore; other site 511437000602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000603 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 511437000604 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 511437000605 potential catalytic triad [active] 511437000606 conserved cys residue [active] 511437000607 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511437000608 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437000609 Walker A/P-loop; other site 511437000610 ATP binding site [chemical binding]; other site 511437000611 Q-loop/lid; other site 511437000612 ABC transporter signature motif; other site 511437000613 Walker B; other site 511437000614 D-loop; other site 511437000615 H-loop/switch region; other site 511437000616 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 511437000617 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 511437000618 N-glycosyltransferase; Provisional; Region: PRK11204 511437000619 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 511437000620 DXD motif; other site 511437000621 Putative catalytic polysaccharide deacetylase domain of bacterial intercellular adhesion protein IcaB and similar proteins; Region: CE4_IcaB_5s; cd10965 511437000622 putative active site [active] 511437000623 putative metal binding site [ion binding]; other site 511437000624 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 511437000625 Helix-turn-helix domain; Region: HTH_38; pfam13936 511437000626 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437000627 Integrase core domain; Region: rve; pfam00665 511437000628 Integrase core domain; Region: rve_3; cl15866 511437000629 aromatic amino acid aminotransferase; Validated; Region: PRK07309 511437000630 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437000631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437000632 homodimer interface [polypeptide binding]; other site 511437000633 catalytic residue [active] 511437000634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437000636 putative substrate translocation pore; other site 511437000637 myosin-cross-reactive antigen; Provisional; Region: PRK13977 511437000638 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 511437000639 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511437000640 glutamate dehydrogenase; Provisional; Region: PRK09414 511437000641 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 511437000642 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 511437000643 NAD(P) binding site [chemical binding]; other site 511437000644 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511437000645 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511437000646 substrate binding pocket [chemical binding]; other site 511437000647 membrane-bound complex binding site; other site 511437000648 hinge residues; other site 511437000649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437000650 dimer interface [polypeptide binding]; other site 511437000651 conserved gate region; other site 511437000652 putative PBP binding loops; other site 511437000653 ABC-ATPase subunit interface; other site 511437000654 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 511437000655 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 511437000656 metal binding site [ion binding]; metal-binding site 511437000657 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 511437000658 Peptidase family M48; Region: Peptidase_M48; cl12018 511437000659 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 511437000660 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437000661 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 511437000662 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 511437000663 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 511437000664 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 511437000665 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 511437000666 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 511437000667 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 511437000668 Prephenate dehydratase; Region: PDT; pfam00800 511437000669 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 511437000670 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 511437000671 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 511437000672 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 511437000673 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 511437000674 NADP binding site [chemical binding]; other site 511437000675 substrate binding site [chemical binding]; other site 511437000676 active site 511437000677 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 511437000678 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 511437000679 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 511437000680 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 511437000681 putative ligand binding site [chemical binding]; other site 511437000682 putative NAD binding site [chemical binding]; other site 511437000683 catalytic site [active] 511437000684 Helix-turn-helix domain; Region: HTH_38; pfam13936 511437000685 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437000686 Integrase core domain; Region: rve; pfam00665 511437000687 Integrase core domain; Region: rve_3; cl15866 511437000688 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511437000689 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437000690 non-specific DNA binding site [nucleotide binding]; other site 511437000691 salt bridge; other site 511437000692 sequence-specific DNA binding site [nucleotide binding]; other site 511437000693 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 511437000694 Isochorismatase family; Region: Isochorismatase; pfam00857 511437000695 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 511437000696 catalytic triad [active] 511437000697 dimer interface [polypeptide binding]; other site 511437000698 conserved cis-peptide bond; other site 511437000699 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 511437000700 amidase catalytic site [active] 511437000701 Zn binding residues [ion binding]; other site 511437000702 substrate binding site [chemical binding]; other site 511437000703 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 511437000704 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 511437000705 metal binding site [ion binding]; metal-binding site 511437000706 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 511437000707 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 511437000708 active site 511437000709 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 511437000710 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 511437000711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511437000712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511437000713 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 511437000714 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 511437000715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 511437000716 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 511437000717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000718 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437000719 putative substrate translocation pore; other site 511437000720 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511437000721 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437000722 DNA binding site [nucleotide binding] 511437000723 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 511437000724 putative dimerization interface [polypeptide binding]; other site 511437000725 putative ligand binding site [chemical binding]; other site 511437000726 beta-D-glucuronidase; Provisional; Region: PRK10150 511437000727 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 511437000728 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 511437000729 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 511437000730 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 511437000731 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 511437000732 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437000733 Coenzyme A binding pocket [chemical binding]; other site 511437000734 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 511437000735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000736 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 511437000737 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 511437000738 catalytic triad [active] 511437000739 EamA-like transporter family; Region: EamA; pfam00892 511437000740 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 511437000741 EamA-like transporter family; Region: EamA; pfam00892 511437000742 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 511437000743 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 511437000744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000745 NADH(P)-binding; Region: NAD_binding_10; pfam13460 511437000746 NAD(P) binding site [chemical binding]; other site 511437000747 active site 511437000748 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437000749 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437000750 active site 511437000751 catalytic tetrad [active] 511437000752 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 511437000753 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 511437000754 DNA binding residues [nucleotide binding] 511437000755 putative dimer interface [polypeptide binding]; other site 511437000756 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 511437000757 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 511437000758 active site 511437000759 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 511437000760 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 511437000761 catalytic triad [active] 511437000762 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 511437000763 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 511437000764 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511437000765 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437000766 Walker A/P-loop; other site 511437000767 ATP binding site [chemical binding]; other site 511437000768 Q-loop/lid; other site 511437000769 ABC transporter signature motif; other site 511437000770 Walker B; other site 511437000771 D-loop; other site 511437000772 H-loop/switch region; other site 511437000773 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511437000774 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511437000775 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 511437000776 Walker A/P-loop; other site 511437000777 ATP binding site [chemical binding]; other site 511437000778 Q-loop/lid; other site 511437000779 ABC transporter signature motif; other site 511437000780 Walker B; other site 511437000781 D-loop; other site 511437000782 H-loop/switch region; other site 511437000783 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 511437000784 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 511437000785 putative dimer interface [polypeptide binding]; other site 511437000786 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 511437000787 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 511437000788 putative dimer interface [polypeptide binding]; other site 511437000789 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 511437000790 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 511437000791 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 511437000792 dimer interface [polypeptide binding]; other site 511437000793 FMN binding site [chemical binding]; other site 511437000794 NADPH bind site [chemical binding]; other site 511437000795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437000796 dimer interface [polypeptide binding]; other site 511437000797 conserved gate region; other site 511437000798 putative PBP binding loops; other site 511437000799 ABC-ATPase subunit interface; other site 511437000800 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511437000801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437000802 dimer interface [polypeptide binding]; other site 511437000803 conserved gate region; other site 511437000804 putative PBP binding loops; other site 511437000805 ABC-ATPase subunit interface; other site 511437000806 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511437000807 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 511437000808 Walker A/P-loop; other site 511437000809 ATP binding site [chemical binding]; other site 511437000810 Q-loop/lid; other site 511437000811 ABC transporter signature motif; other site 511437000812 Walker B; other site 511437000813 D-loop; other site 511437000814 H-loop/switch region; other site 511437000815 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 511437000816 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511437000817 substrate binding pocket [chemical binding]; other site 511437000818 membrane-bound complex binding site; other site 511437000819 hinge residues; other site 511437000820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000821 putative substrate translocation pore; other site 511437000822 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437000823 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 511437000824 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 511437000825 active site 511437000826 catalytic residue [active] 511437000827 dimer interface [polypeptide binding]; other site 511437000828 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 511437000829 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 511437000830 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511437000831 peptide binding site [polypeptide binding]; other site 511437000832 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 511437000833 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511437000834 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 511437000835 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 511437000836 active site 511437000837 Chorismate mutase type II; Region: CM_2; pfam01817 511437000838 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 511437000839 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 511437000840 Tetramer interface [polypeptide binding]; other site 511437000841 active site 511437000842 FMN-binding site [chemical binding]; other site 511437000843 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 511437000844 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 511437000845 hinge; other site 511437000846 active site 511437000847 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 511437000848 prephenate dehydrogenase; Validated; Region: PRK08507 511437000849 shikimate kinase; Reviewed; Region: aroK; PRK00131 511437000850 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 511437000851 ADP binding site [chemical binding]; other site 511437000852 magnesium binding site [ion binding]; other site 511437000853 putative shikimate binding site; other site 511437000854 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 511437000855 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 511437000856 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 511437000857 shikimate binding site; other site 511437000858 NAD(P) binding site [chemical binding]; other site 511437000859 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 511437000860 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 511437000861 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511437000862 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437000863 DNA binding site [nucleotide binding] 511437000864 domain linker motif; other site 511437000865 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 511437000866 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 511437000867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000868 putative substrate translocation pore; other site 511437000869 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 511437000870 HPr interaction site; other site 511437000871 glycerol kinase (GK) interaction site [polypeptide binding]; other site 511437000872 active site 511437000873 phosphorylation site [posttranslational modification] 511437000874 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 511437000875 Melibiase; Region: Melibiase; pfam02065 511437000876 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 511437000877 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 511437000878 active site 511437000879 substrate binding site [chemical binding]; other site 511437000880 trimer interface [polypeptide binding]; other site 511437000881 CoA binding site [chemical binding]; other site 511437000882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000883 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437000884 putative substrate translocation pore; other site 511437000885 EDD domain protein, DegV family; Region: DegV; TIGR00762 511437000886 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 511437000887 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 511437000888 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 511437000889 Putative amidase domain; Region: Amidase_6; pfam12671 511437000890 PemK-like protein; Region: PemK; cl00995 511437000891 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 511437000892 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 511437000893 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 511437000894 Catalytic site [active] 511437000895 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 511437000896 PemK-like protein; Region: PemK; pfam02452 511437000897 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 511437000898 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 511437000899 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 511437000900 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 511437000901 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 511437000902 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 511437000903 ATP-grasp domain; Region: ATP-grasp_4; cl17255 511437000904 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 511437000905 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 511437000906 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 511437000907 catalytic site [active] 511437000908 subunit interface [polypeptide binding]; other site 511437000909 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 511437000910 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 511437000911 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 511437000912 dihydroorotase; Validated; Region: pyrC; PRK09357 511437000913 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511437000914 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 511437000915 active site 511437000916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437000917 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437000918 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 511437000919 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 511437000920 dimer interface [polypeptide binding]; other site 511437000921 active site 511437000922 ADP-ribose binding site [chemical binding]; other site 511437000923 nudix motif; other site 511437000924 metal binding site [ion binding]; metal-binding site 511437000925 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 511437000926 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 511437000927 YcfA-like protein; Region: YcfA; cl00752 511437000928 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 511437000929 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 511437000930 putative ligand binding site [chemical binding]; other site 511437000931 putative NAD binding site [chemical binding]; other site 511437000932 putative catalytic site [active] 511437000933 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 511437000934 L-serine binding site [chemical binding]; other site 511437000935 ACT domain interface; other site 511437000936 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 511437000937 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511437000938 catalytic residue [active] 511437000939 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437000940 catalytic core [active] 511437000941 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511437000942 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511437000943 peptide binding site [polypeptide binding]; other site 511437000944 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 511437000945 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511437000946 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 511437000947 NAD binding site [chemical binding]; other site 511437000948 dimer interface [polypeptide binding]; other site 511437000949 substrate binding site [chemical binding]; other site 511437000950 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 511437000951 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 511437000952 UbiA prenyltransferase family; Region: UbiA; pfam01040 511437000953 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 511437000954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437000955 S-adenosylmethionine binding site [chemical binding]; other site 511437000956 aromatic amino acid aminotransferase; Validated; Region: PRK07309 511437000957 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437000958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437000959 homodimer interface [polypeptide binding]; other site 511437000960 catalytic residue [active] 511437000961 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 511437000962 D-lactate dehydrogenase; Validated; Region: PRK08605 511437000963 homodimer interface [polypeptide binding]; other site 511437000964 ligand binding site [chemical binding]; other site 511437000965 NAD binding site [chemical binding]; other site 511437000966 catalytic site [active] 511437000967 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 511437000968 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437000969 Helix-turn-helix domain; Region: HTH_38; pfam13936 511437000970 Integrase core domain; Region: rve; pfam00665 511437000971 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 511437000972 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511437000973 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 511437000974 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 511437000975 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437000976 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437000977 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 511437000978 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511437000979 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511437000980 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437000981 Walker A/P-loop; other site 511437000982 ATP binding site [chemical binding]; other site 511437000983 Q-loop/lid; other site 511437000984 ABC transporter signature motif; other site 511437000985 H-loop/switch region; other site 511437000986 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 511437000987 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511437000988 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 511437000989 Abi-like protein; Region: Abi_2; pfam07751 511437000990 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 511437000991 catalytic residues [active] 511437000992 dimer interface [polypeptide binding]; other site 511437000993 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 511437000994 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 511437000995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511437000996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511437000997 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 511437000998 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 511437000999 FtsX-like permease family; Region: FtsX; pfam02687 511437001000 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511437001001 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 511437001002 Walker A/P-loop; other site 511437001003 ATP binding site [chemical binding]; other site 511437001004 Q-loop/lid; other site 511437001005 ABC transporter signature motif; other site 511437001006 Walker B; other site 511437001007 D-loop; other site 511437001008 H-loop/switch region; other site 511437001009 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 511437001010 CoenzymeA binding site [chemical binding]; other site 511437001011 subunit interaction site [polypeptide binding]; other site 511437001012 PHB binding site; other site 511437001013 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 511437001014 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 511437001015 substrate binding site [chemical binding]; other site 511437001016 oxyanion hole (OAH) forming residues; other site 511437001017 trimer interface [polypeptide binding]; other site 511437001018 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 511437001019 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 511437001020 acyl-activating enzyme (AAE) consensus motif; other site 511437001021 putative AMP binding site [chemical binding]; other site 511437001022 putative active site [active] 511437001023 putative CoA binding site [chemical binding]; other site 511437001024 putrescine carbamoyltransferase; Provisional; Region: PRK02255 511437001025 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 511437001026 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 511437001027 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 511437001028 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 511437001029 agmatine deiminase; Provisional; Region: PRK13551 511437001030 agmatine deiminase; Region: agmatine_aguA; TIGR03380 511437001031 carbamate kinase; Reviewed; Region: PRK12686 511437001032 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 511437001033 putative substrate binding site [chemical binding]; other site 511437001034 nucleotide binding site [chemical binding]; other site 511437001035 nucleotide binding site [chemical binding]; other site 511437001036 homodimer interface [polypeptide binding]; other site 511437001037 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 511437001038 agmatine deiminase; Region: agmatine_aguA; TIGR03380 511437001039 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 511437001040 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 511437001041 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 511437001042 putative active site [active] 511437001043 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 511437001044 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 511437001045 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437001046 Soluble P-type ATPase [General function prediction only]; Region: COG4087 511437001047 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437001048 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437001049 active site 511437001050 catalytic tetrad [active] 511437001051 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 511437001052 HD domain; Region: HD; pfam01966 511437001053 polyphosphate kinase; Provisional; Region: PRK05443 511437001054 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 511437001055 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 511437001056 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 511437001057 putative domain interface [polypeptide binding]; other site 511437001058 putative active site [active] 511437001059 catalytic site [active] 511437001060 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 511437001061 putative domain interface [polypeptide binding]; other site 511437001062 putative active site [active] 511437001063 catalytic site [active] 511437001064 exopolyphosphatase; Region: exo_poly_only; TIGR03706 511437001065 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 511437001066 VanZ like family; Region: VanZ; pfam04892 511437001067 RDD family; Region: RDD; pfam06271 511437001068 Uncharacterized conserved protein [Function unknown]; Region: COG1434 511437001069 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 511437001070 putative active site [active] 511437001071 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 511437001072 ArsC family; Region: ArsC; pfam03960 511437001073 putative catalytic residues [active] 511437001074 thiol/disulfide switch; other site 511437001075 transaminase; Validated; Region: PRK07324 511437001076 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437001077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437001078 homodimer interface [polypeptide binding]; other site 511437001079 catalytic residue [active] 511437001080 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 511437001081 FAD binding site [chemical binding]; other site 511437001082 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 511437001083 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 511437001084 THF binding site; other site 511437001085 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 511437001086 substrate binding site [chemical binding]; other site 511437001087 THF binding site; other site 511437001088 zinc-binding site [ion binding]; other site 511437001089 S-ribosylhomocysteinase; Provisional; Region: PRK02260 511437001090 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511437001091 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511437001092 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 511437001093 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 511437001094 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 511437001095 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 511437001096 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 511437001097 Walker A/P-loop; other site 511437001098 ATP binding site [chemical binding]; other site 511437001099 Q-loop/lid; other site 511437001100 ABC transporter signature motif; other site 511437001101 Walker B; other site 511437001102 D-loop; other site 511437001103 H-loop/switch region; other site 511437001104 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 511437001105 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 511437001106 Na binding site [ion binding]; other site 511437001107 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 511437001108 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 511437001109 Cobalt transport protein; Region: CbiQ; cl00463 511437001110 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 511437001111 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 511437001112 Walker A/P-loop; other site 511437001113 ATP binding site [chemical binding]; other site 511437001114 Q-loop/lid; other site 511437001115 ABC transporter signature motif; other site 511437001116 Walker B; other site 511437001117 D-loop; other site 511437001118 H-loop/switch region; other site 511437001119 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 511437001120 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 511437001121 Walker A/P-loop; other site 511437001122 ATP binding site [chemical binding]; other site 511437001123 Q-loop/lid; other site 511437001124 ABC transporter signature motif; other site 511437001125 Walker B; other site 511437001126 D-loop; other site 511437001127 H-loop/switch region; other site 511437001128 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 511437001129 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 511437001130 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 511437001131 Ligand binding site [chemical binding]; other site 511437001132 Electron transfer flavoprotein domain; Region: ETF; pfam01012 511437001133 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 511437001134 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 511437001135 active site 511437001136 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511437001137 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437001138 non-specific DNA binding site [nucleotide binding]; other site 511437001139 salt bridge; other site 511437001140 sequence-specific DNA binding site [nucleotide binding]; other site 511437001141 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 511437001142 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 511437001143 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511437001144 MarR family; Region: MarR; pfam01047 511437001145 manganese transport protein MntH; Reviewed; Region: PRK00701 511437001146 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 511437001147 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511437001148 Ligand Binding Site [chemical binding]; other site 511437001149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437001150 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437001151 putative substrate translocation pore; other site 511437001152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437001153 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 511437001154 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 511437001155 NAD(P) binding site [chemical binding]; other site 511437001156 catalytic residues [active] 511437001157 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 511437001158 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 511437001159 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 511437001160 putative active site [active] 511437001161 nucleotide binding site [chemical binding]; other site 511437001162 nudix motif; other site 511437001163 putative metal binding site [ion binding]; other site 511437001164 Predicted transcriptional regulators [Transcription]; Region: COG1733 511437001165 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 511437001166 intracellular protease, PfpI family; Region: PfpI; TIGR01382 511437001167 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 511437001168 proposed catalytic triad [active] 511437001169 conserved cys residue [active] 511437001170 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 511437001171 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 511437001172 NADH(P)-binding; Region: NAD_binding_10; pfam13460 511437001173 NAD(P) binding site [chemical binding]; other site 511437001174 putative active site [active] 511437001175 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 511437001176 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437001177 Soluble P-type ATPase [General function prediction only]; Region: COG4087 511437001178 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 511437001179 metal-binding site [ion binding] 511437001180 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 511437001181 Ferritin-like domain; Region: Ferritin; pfam00210 511437001182 dinuclear metal binding motif [ion binding]; other site 511437001183 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 511437001184 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 511437001185 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 511437001186 NAD binding site [chemical binding]; other site 511437001187 ATP-grasp domain; Region: ATP-grasp; pfam02222 511437001188 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 511437001189 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 511437001190 ATP binding site [chemical binding]; other site 511437001191 active site 511437001192 substrate binding site [chemical binding]; other site 511437001193 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 511437001194 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 511437001195 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 511437001196 putative active site [active] 511437001197 catalytic triad [active] 511437001198 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 511437001199 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 511437001200 dimerization interface [polypeptide binding]; other site 511437001201 ATP binding site [chemical binding]; other site 511437001202 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 511437001203 dimerization interface [polypeptide binding]; other site 511437001204 ATP binding site [chemical binding]; other site 511437001205 amidophosphoribosyltransferase; Provisional; Region: PRK07272 511437001206 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 511437001207 active site 511437001208 tetramer interface [polypeptide binding]; other site 511437001209 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437001210 active site 511437001211 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 511437001212 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 511437001213 dimerization interface [polypeptide binding]; other site 511437001214 putative ATP binding site [chemical binding]; other site 511437001215 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 511437001216 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 511437001217 active site 511437001218 substrate binding site [chemical binding]; other site 511437001219 cosubstrate binding site; other site 511437001220 catalytic site [active] 511437001221 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 511437001222 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 511437001223 purine monophosphate binding site [chemical binding]; other site 511437001224 dimer interface [polypeptide binding]; other site 511437001225 putative catalytic residues [active] 511437001226 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 511437001227 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 511437001228 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 511437001229 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 511437001230 ATP-grasp domain; Region: ATP-grasp_4; cl17255 511437001231 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 511437001232 hypothetical protein; Validated; Region: PRK02101 511437001233 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 511437001234 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 511437001235 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 511437001236 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437001237 active site 511437001238 motif I; other site 511437001239 motif II; other site 511437001240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437001241 benzoate transport; Region: 2A0115; TIGR00895 511437001242 putative substrate translocation pore; other site 511437001243 PemK-like protein; Region: PemK; pfam02452 511437001244 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 511437001245 active site 511437001246 dimer interface [polypeptide binding]; other site 511437001247 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437001248 active site 511437001249 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 511437001250 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 511437001251 active site 511437001252 FMN binding site [chemical binding]; other site 511437001253 substrate binding site [chemical binding]; other site 511437001254 catalytic residues [active] 511437001255 homodimer interface [polypeptide binding]; other site 511437001256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437001257 Walker A/P-loop; other site 511437001258 ATP binding site [chemical binding]; other site 511437001259 Q-loop/lid; other site 511437001260 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437001261 ABC transporter signature motif; other site 511437001262 Walker B; other site 511437001263 D-loop; other site 511437001264 H-loop/switch region; other site 511437001265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437001266 AAA domain; Region: AAA_21; pfam13304 511437001267 Walker A/P-loop; other site 511437001268 ATP binding site [chemical binding]; other site 511437001269 Q-loop/lid; other site 511437001270 ABC transporter signature motif; other site 511437001271 Walker B; other site 511437001272 D-loop; other site 511437001273 H-loop/switch region; other site 511437001274 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 511437001275 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511437001276 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 511437001277 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511437001278 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 511437001279 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511437001280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437001281 putative substrate translocation pore; other site 511437001282 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 511437001283 xylose isomerase; Provisional; Region: PRK05474 511437001284 xylose isomerase; Region: xylose_isom_A; TIGR02630 511437001285 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 511437001286 N- and C-terminal domain interface [polypeptide binding]; other site 511437001287 D-xylulose kinase; Region: XylB; TIGR01312 511437001288 active site 511437001289 MgATP binding site [chemical binding]; other site 511437001290 catalytic site [active] 511437001291 metal binding site [ion binding]; metal-binding site 511437001292 xylulose binding site [chemical binding]; other site 511437001293 homodimer interface [polypeptide binding]; other site 511437001294 TIGR03987 family protein; Region: TIGR03987 511437001295 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 511437001296 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 511437001297 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511437001298 putative DNA binding site [nucleotide binding]; other site 511437001299 putative Zn2+ binding site [ion binding]; other site 511437001300 AsnC family; Region: AsnC_trans_reg; pfam01037 511437001301 drug efflux system protein MdtG; Provisional; Region: PRK09874 511437001302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437001303 putative substrate translocation pore; other site 511437001304 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437001305 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437001306 active site 511437001307 catalytic tetrad [active] 511437001308 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 511437001309 NADH(P)-binding; Region: NAD_binding_10; pfam13460 511437001310 putative NAD(P) binding site [chemical binding]; other site 511437001311 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 511437001312 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 511437001313 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 511437001314 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 511437001315 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 511437001316 Walker A/P-loop; other site 511437001317 ATP binding site [chemical binding]; other site 511437001318 Q-loop/lid; other site 511437001319 ABC transporter signature motif; other site 511437001320 Walker B; other site 511437001321 D-loop; other site 511437001322 H-loop/switch region; other site 511437001323 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 511437001324 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 511437001325 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437001326 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437001327 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437001328 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 511437001329 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 511437001330 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 511437001331 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 511437001332 Protein of unknown function (DUF1168); Region: DUF1168; pfam06658 511437001333 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 511437001334 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 511437001335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 511437001336 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 511437001337 active site 511437001338 Fe-S cluster binding site [ion binding]; other site 511437001339 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 511437001340 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 511437001341 lipoyl attachment site [posttranslational modification]; other site 511437001342 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 511437001343 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 511437001344 tetramer interface [polypeptide binding]; other site 511437001345 active site 511437001346 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 511437001347 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 511437001348 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 511437001349 lipoyl attachment site [posttranslational modification]; other site 511437001350 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437001351 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437001352 active site 511437001353 catalytic tetrad [active] 511437001354 Predicted membrane protein [Function unknown]; Region: COG3428 511437001355 Bacterial PH domain; Region: DUF304; pfam03703 511437001356 Bacterial PH domain; Region: DUF304; pfam03703 511437001357 Bacterial PH domain; Region: DUF304; pfam03703 511437001358 Uncharacterized conserved protein [Function unknown]; Region: COG3402 511437001359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437001360 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437001361 putative substrate translocation pore; other site 511437001362 acetoin reductase; Validated; Region: PRK08643 511437001363 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 511437001364 NAD binding site [chemical binding]; other site 511437001365 homotetramer interface [polypeptide binding]; other site 511437001366 homodimer interface [polypeptide binding]; other site 511437001367 active site 511437001368 substrate binding site [chemical binding]; other site 511437001369 Integral membrane protein DUF95; Region: DUF95; cl00572 511437001370 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437001371 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437001372 active site 511437001373 catalytic tetrad [active] 511437001374 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511437001375 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 511437001376 Walker A/P-loop; other site 511437001377 ATP binding site [chemical binding]; other site 511437001378 Q-loop/lid; other site 511437001379 ABC transporter signature motif; other site 511437001380 Walker B; other site 511437001381 D-loop; other site 511437001382 H-loop/switch region; other site 511437001383 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 511437001384 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 511437001385 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511437001386 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511437001387 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 511437001388 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 511437001389 3D domain; Region: 3D; cl01439 511437001390 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 511437001391 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 511437001392 ligand binding site [chemical binding]; other site 511437001393 flexible hinge region; other site 511437001394 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 511437001395 non-specific DNA interactions [nucleotide binding]; other site 511437001396 DNA binding site [nucleotide binding] 511437001397 sequence specific DNA binding site [nucleotide binding]; other site 511437001398 putative cAMP binding site [chemical binding]; other site 511437001399 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 511437001400 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 511437001401 putative N- and C-terminal domain interface [polypeptide binding]; other site 511437001402 putative active site [active] 511437001403 MgATP binding site [chemical binding]; other site 511437001404 catalytic site [active] 511437001405 metal binding site [ion binding]; metal-binding site 511437001406 putative carbohydrate binding site [chemical binding]; other site 511437001407 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 511437001408 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 511437001409 intersubunit interface [polypeptide binding]; other site 511437001410 active site 511437001411 Zn2+ binding site [ion binding]; other site 511437001412 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 511437001413 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 511437001414 active site 511437001415 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 511437001416 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 511437001417 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 511437001418 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 511437001419 active site 511437001420 metal binding site [ion binding]; metal-binding site 511437001421 hexamer interface [polypeptide binding]; other site 511437001422 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 511437001423 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 511437001424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437001425 Coenzyme A binding pocket [chemical binding]; other site 511437001426 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 511437001427 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 511437001428 active site 511437001429 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 511437001430 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511437001431 ABC transporter; Region: ABC_tran_2; pfam12848 511437001432 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511437001433 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 511437001434 catalytic triad [active] 511437001435 catalytic triad [active] 511437001436 oxyanion hole [active] 511437001437 Serine hydrolase; Region: Ser_hydrolase; cl17834 511437001438 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 511437001439 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 511437001440 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 511437001441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437001442 NAD(P) binding site [chemical binding]; other site 511437001443 active site 511437001444 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511437001445 Helix-turn-helix domain; Region: HTH_28; pfam13518 511437001446 Helix-turn-helix domain; Region: HTH_28; pfam13518 511437001447 putative transposase OrfB; Reviewed; Region: PHA02517 511437001448 HTH-like domain; Region: HTH_21; pfam13276 511437001449 Integrase core domain; Region: rve; pfam00665 511437001450 Integrase core domain; Region: rve_3; pfam13683 511437001451 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 511437001452 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437001453 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437001454 active site 511437001455 catalytic tetrad [active] 511437001456 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 511437001457 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 511437001458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437001459 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437001460 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 511437001461 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 511437001462 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 511437001463 xanthine permease; Region: pbuX; TIGR03173 511437001464 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511437001465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511437001466 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 511437001467 dimerization interface [polypeptide binding]; other site 511437001468 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 511437001469 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 511437001470 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 511437001471 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 511437001472 Arginine repressor [Transcription]; Region: ArgR; COG1438 511437001473 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 511437001474 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 511437001475 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 511437001476 arginine deiminase; Provisional; Region: PRK01388 511437001477 ornithine carbamoyltransferase; Validated; Region: PRK02102 511437001478 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 511437001479 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 511437001480 carbamate kinase; Reviewed; Region: PRK12686 511437001481 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 511437001482 putative substrate binding site [chemical binding]; other site 511437001483 nucleotide binding site [chemical binding]; other site 511437001484 nucleotide binding site [chemical binding]; other site 511437001485 homodimer interface [polypeptide binding]; other site 511437001486 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 511437001487 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 511437001488 ligand binding site [chemical binding]; other site 511437001489 flexible hinge region; other site 511437001490 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 511437001491 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 511437001492 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 511437001493 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 511437001494 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437001495 motif II; other site 511437001496 DsrE/DsrF-like family; Region: DrsE; cl00672 511437001497 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 511437001498 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 511437001499 DNA binding site [nucleotide binding] 511437001500 active site 511437001501 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511437001502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437001503 non-specific DNA binding site [nucleotide binding]; other site 511437001504 salt bridge; other site 511437001505 sequence-specific DNA binding site [nucleotide binding]; other site 511437001506 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 511437001507 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 511437001508 phosphodiesterase; Provisional; Region: PRK12704 511437001509 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511437001510 Zn2+ binding site [ion binding]; other site 511437001511 Mg2+ binding site [ion binding]; other site 511437001512 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 511437001513 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 511437001514 active site 511437001515 metal binding site [ion binding]; metal-binding site 511437001516 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 511437001517 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 511437001518 putative catalytic residues [active] 511437001519 thiol/disulfide switch; other site 511437001520 ArsC family; Region: ArsC; pfam03960 511437001521 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 511437001522 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437001523 active site 511437001524 motif I; other site 511437001525 motif II; other site 511437001526 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 511437001527 Helix-turn-helix domain; Region: HTH_38; pfam13936 511437001528 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437001529 Integrase core domain; Region: rve; pfam00665 511437001530 Integrase core domain; Region: rve_3; cl15866 511437001531 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 511437001532 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 511437001533 active site 511437001534 active site 511437001535 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 511437001536 active site 511437001537 Protease prsW family; Region: PrsW-protease; cl15823 511437001538 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 511437001539 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 511437001540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437001541 Walker A/P-loop; other site 511437001542 ATP binding site [chemical binding]; other site 511437001543 Q-loop/lid; other site 511437001544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437001545 ABC transporter signature motif; other site 511437001546 Walker B; other site 511437001547 D-loop; other site 511437001548 H-loop/switch region; other site 511437001549 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437001550 AAA domain; Region: AAA_21; pfam13304 511437001551 Walker A/P-loop; other site 511437001552 ATP binding site [chemical binding]; other site 511437001553 Q-loop/lid; other site 511437001554 ABC transporter signature motif; other site 511437001555 Walker B; other site 511437001556 D-loop; other site 511437001557 H-loop/switch region; other site 511437001558 Ion channel; Region: Ion_trans_2; pfam07885 511437001559 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 511437001560 Sulfatase; Region: Sulfatase; pfam00884 511437001561 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437001562 catalytic core [active] 511437001563 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 511437001564 Coenzyme A binding pocket [chemical binding]; other site 511437001565 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 511437001566 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 511437001567 Acyltransferase family; Region: Acyl_transf_3; pfam01757 511437001568 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437001569 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437001570 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 511437001571 NlpC/P60 family; Region: NLPC_P60; pfam00877 511437001572 Transport protein; Region: actII; TIGR00833 511437001573 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 511437001574 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 511437001575 active site 511437001576 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 511437001577 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 511437001578 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 511437001579 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 511437001580 catalytic residues [active] 511437001581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437001582 Coenzyme A binding pocket [chemical binding]; other site 511437001583 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 511437001584 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 511437001585 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 511437001586 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 511437001587 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 511437001588 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 511437001589 active site 511437001590 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 511437001591 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 511437001592 GDP-binding site [chemical binding]; other site 511437001593 ACT binding site; other site 511437001594 IMP binding site; other site 511437001595 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 511437001596 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 511437001597 tetramer interface [polypeptide binding]; other site 511437001598 active site 511437001599 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 511437001600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 511437001601 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 511437001602 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 511437001603 Predicted membrane protein [Function unknown]; Region: COG2364 511437001604 glycerol kinase; Provisional; Region: glpK; PRK00047 511437001605 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 511437001606 N- and C-terminal domain interface [polypeptide binding]; other site 511437001607 active site 511437001608 MgATP binding site [chemical binding]; other site 511437001609 catalytic site [active] 511437001610 metal binding site [ion binding]; metal-binding site 511437001611 glycerol binding site [chemical binding]; other site 511437001612 homotetramer interface [polypeptide binding]; other site 511437001613 homodimer interface [polypeptide binding]; other site 511437001614 FBP binding site [chemical binding]; other site 511437001615 protein IIAGlc interface [polypeptide binding]; other site 511437001616 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 511437001617 TRAM domain; Region: TRAM; pfam01938 511437001618 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 511437001619 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437001620 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437001621 active site 511437001622 catalytic tetrad [active] 511437001623 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 511437001624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437001625 Coenzyme A binding pocket [chemical binding]; other site 511437001626 short chain dehydrogenase; Validated; Region: PRK06182 511437001627 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 511437001628 NADP binding site [chemical binding]; other site 511437001629 active site 511437001630 steroid binding site; other site 511437001631 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 511437001632 substrate binding site [chemical binding]; other site 511437001633 multimerization interface [polypeptide binding]; other site 511437001634 ATP binding site [chemical binding]; other site 511437001635 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 511437001636 substrate binding site [chemical binding]; other site 511437001637 dimer interface [polypeptide binding]; other site 511437001638 ATP binding site [chemical binding]; other site 511437001639 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 511437001640 thiamine phosphate binding site [chemical binding]; other site 511437001641 active site 511437001642 pyrophosphate binding site [ion binding]; other site 511437001643 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 511437001644 active site 511437001645 Protein of unknown function (DUF1516); Region: DUF1516; pfam07457 511437001646 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 511437001647 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 511437001648 active site 511437001649 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 511437001650 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437001651 non-specific DNA binding site [nucleotide binding]; other site 511437001652 salt bridge; other site 511437001653 sequence-specific DNA binding site [nucleotide binding]; other site 511437001654 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511437001655 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 511437001656 Walker A/P-loop; other site 511437001657 ATP binding site [chemical binding]; other site 511437001658 Q-loop/lid; other site 511437001659 ABC transporter signature motif; other site 511437001660 Walker B; other site 511437001661 D-loop; other site 511437001662 H-loop/switch region; other site 511437001663 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 511437001664 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 511437001665 FtsX-like permease family; Region: FtsX; pfam02687 511437001666 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 511437001667 EDD domain protein, DegV family; Region: DegV; TIGR00762 511437001668 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 511437001669 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 511437001670 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 511437001671 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 511437001672 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 511437001673 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 511437001674 RelB antitoxin; Region: RelB; cl01171 511437001675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 511437001676 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 511437001677 NlpC/P60 family; Region: NLPC_P60; pfam00877 511437001678 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 511437001679 dimerization domain swap beta strand [polypeptide binding]; other site 511437001680 regulatory protein interface [polypeptide binding]; other site 511437001681 active site 511437001682 regulatory phosphorylation site [posttranslational modification]; other site 511437001683 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 511437001684 peptidase domain interface [polypeptide binding]; other site 511437001685 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 511437001686 active site 511437001687 catalytic triad [active] 511437001688 calcium binding site [ion binding]; other site 511437001689 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511437001690 Helix-turn-helix domain; Region: HTH_28; pfam13518 511437001691 Helix-turn-helix domain; Region: HTH_28; pfam13518 511437001692 putative transposase OrfB; Reviewed; Region: PHA02517 511437001693 HTH-like domain; Region: HTH_21; pfam13276 511437001694 Integrase core domain; Region: rve; pfam00665 511437001695 Integrase core domain; Region: rve_3; pfam13683 511437001696 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 511437001697 putative deacylase active site [active] 511437001698 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 511437001699 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511437001700 DNA binding residues [nucleotide binding] 511437001701 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 511437001702 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 511437001703 active site 511437001704 zinc binding site [ion binding]; other site 511437001705 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 511437001706 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 511437001707 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 511437001708 active site 511437001709 catalytic triad [active] 511437001710 oxyanion hole [active] 511437001711 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 511437001712 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 511437001713 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 511437001714 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 511437001715 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 511437001716 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 511437001717 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 511437001718 active site 511437001719 tetramer interface [polypeptide binding]; other site 511437001720 peptidase T; Region: peptidase-T; TIGR01882 511437001721 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 511437001722 metal binding site [ion binding]; metal-binding site 511437001723 dimer interface [polypeptide binding]; other site 511437001724 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 511437001725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437001726 S-adenosylmethionine binding site [chemical binding]; other site 511437001727 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 511437001728 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 511437001729 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 511437001730 Magnesium ion binding site [ion binding]; other site 511437001731 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 511437001732 ParB-like nuclease domain; Region: ParB; smart00470 511437001733 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 511437001734 GTP-binding protein YchF; Reviewed; Region: PRK09601 511437001735 YchF GTPase; Region: YchF; cd01900 511437001736 G1 box; other site 511437001737 GTP/Mg2+ binding site [chemical binding]; other site 511437001738 Switch I region; other site 511437001739 G2 box; other site 511437001740 Switch II region; other site 511437001741 G3 box; other site 511437001742 G4 box; other site 511437001743 G5 box; other site 511437001744 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 511437001745 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 511437001746 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 511437001747 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 511437001748 active site 511437001749 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 511437001750 nudix motif; other site 511437001751 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 511437001752 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 511437001753 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 511437001754 active site 511437001755 myosin-cross-reactive antigen; Provisional; Region: PRK13977 511437001756 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511437001757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511437001758 active site 511437001759 phosphorylation site [posttranslational modification] 511437001760 intermolecular recognition site; other site 511437001761 dimerization interface [polypeptide binding]; other site 511437001762 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511437001763 DNA binding site [nucleotide binding] 511437001764 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 511437001765 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511437001766 dimer interface [polypeptide binding]; other site 511437001767 phosphorylation site [posttranslational modification] 511437001768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437001769 ATP binding site [chemical binding]; other site 511437001770 Mg2+ binding site [ion binding]; other site 511437001771 G-X-G motif; other site 511437001772 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 511437001773 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 511437001774 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 511437001775 AzlC protein; Region: AzlC; pfam03591 511437001776 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 511437001777 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 511437001778 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 511437001779 Domain of unknown function DUF20; Region: UPF0118; pfam01594 511437001780 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437001781 catalytic core [active] 511437001782 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437001783 inner membrane transporter YjeM; Provisional; Region: PRK15238 511437001784 maltose O-acetyltransferase; Provisional; Region: PRK10092 511437001785 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 511437001786 active site 511437001787 substrate binding site [chemical binding]; other site 511437001788 trimer interface [polypeptide binding]; other site 511437001789 CoA binding site [chemical binding]; other site 511437001790 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 511437001791 endonuclease III; Region: ENDO3c; smart00478 511437001792 minor groove reading motif; other site 511437001793 helix-hairpin-helix signature motif; other site 511437001794 substrate binding pocket [chemical binding]; other site 511437001795 active site 511437001796 Sugar transport protein; Region: Sugar_transport; pfam06800 511437001797 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 511437001798 DNA-binding site [nucleotide binding]; DNA binding site 511437001799 RNA-binding motif; other site 511437001800 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 511437001801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511437001802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511437001803 manganese transport protein MntH; Reviewed; Region: PRK00701 511437001804 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 511437001805 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 511437001806 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 511437001807 Cl binding site [ion binding]; other site 511437001808 oligomer interface [polypeptide binding]; other site 511437001809 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 511437001810 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 511437001811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437001812 putative substrate translocation pore; other site 511437001813 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437001814 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 511437001815 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 511437001816 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 511437001817 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 511437001818 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 511437001819 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 511437001820 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 511437001821 CAAX protease self-immunity; Region: Abi; pfam02517 511437001822 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 511437001823 active site 511437001824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437001825 Coenzyme A binding pocket [chemical binding]; other site 511437001826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437001827 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437001828 putative substrate translocation pore; other site 511437001829 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 511437001830 nudix motif; other site 511437001831 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 511437001832 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 511437001833 putative ligand binding site [chemical binding]; other site 511437001834 putative NAD binding site [chemical binding]; other site 511437001835 catalytic site [active] 511437001836 Fic/DOC family; Region: Fic; pfam02661 511437001837 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 511437001838 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437001839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437001840 homodimer interface [polypeptide binding]; other site 511437001841 catalytic residue [active] 511437001842 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 511437001843 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 511437001844 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 511437001845 NAD(P) binding site [chemical binding]; other site 511437001846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437001847 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 511437001848 NAD(P) binding site [chemical binding]; other site 511437001849 active site 511437001850 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 511437001851 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 511437001852 Transcriptional regulators [Transcription]; Region: GntR; COG1802 511437001853 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511437001854 DNA-binding site [nucleotide binding]; DNA binding site 511437001855 FCD domain; Region: FCD; pfam07729 511437001856 mannonate dehydratase; Provisional; Region: PRK03906 511437001857 mannonate dehydratase; Region: uxuA; TIGR00695 511437001858 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 511437001859 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 511437001860 substrate binding site [chemical binding]; other site 511437001861 ATP binding site [chemical binding]; other site 511437001862 Protein of unknown function (DUF975); Region: DUF975; cl10504 511437001863 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 511437001864 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 511437001865 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 511437001866 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 511437001867 histidinol dehydrogenase; Region: hisD; TIGR00069 511437001868 NAD binding site [chemical binding]; other site 511437001869 dimerization interface [polypeptide binding]; other site 511437001870 product binding site; other site 511437001871 substrate binding site [chemical binding]; other site 511437001872 zinc binding site [ion binding]; other site 511437001873 catalytic residues [active] 511437001874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437001875 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437001876 putative substrate translocation pore; other site 511437001877 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 511437001878 amphipathic channel; other site 511437001879 Asn-Pro-Ala signature motifs; other site 511437001880 Protein of unknown function (DUF975); Region: DUF975; cl10504 511437001881 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 511437001882 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 511437001883 homodimer interface [polypeptide binding]; other site 511437001884 substrate-cofactor binding pocket; other site 511437001885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437001886 catalytic residue [active] 511437001887 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 511437001888 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 511437001889 dimer interface [polypeptide binding]; other site 511437001890 active site 511437001891 metal binding site [ion binding]; metal-binding site 511437001892 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 511437001893 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 511437001894 NAD binding site [chemical binding]; other site 511437001895 substrate binding site [chemical binding]; other site 511437001896 homodimer interface [polypeptide binding]; other site 511437001897 active site 511437001898 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 511437001899 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 511437001900 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 511437001901 DNA binding residues [nucleotide binding] 511437001902 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 511437001903 putative dimer interface [polypeptide binding]; other site 511437001904 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 511437001905 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 511437001906 active site 511437001907 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 511437001908 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 511437001909 active site 511437001910 HIGH motif; other site 511437001911 dimer interface [polypeptide binding]; other site 511437001912 KMSKS motif; other site 511437001913 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511437001914 RNA binding surface [nucleotide binding]; other site 511437001915 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 511437001916 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 511437001917 ArsC family; Region: ArsC; pfam03960 511437001918 putative catalytic residues [active] 511437001919 thiol/disulfide switch; other site 511437001920 adaptor protein; Provisional; Region: PRK02315 511437001921 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 511437001922 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 511437001923 Ligand binding site; other site 511437001924 Putative Catalytic site; other site 511437001925 DXD motif; other site 511437001926 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 511437001927 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 511437001928 GtrA-like protein; Region: GtrA; pfam04138 511437001929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511437001930 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511437001931 active site 511437001932 phosphorylation site [posttranslational modification] 511437001933 intermolecular recognition site; other site 511437001934 dimerization interface [polypeptide binding]; other site 511437001935 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511437001936 DNA binding site [nucleotide binding] 511437001937 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 511437001938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511437001939 dimer interface [polypeptide binding]; other site 511437001940 phosphorylation site [posttranslational modification] 511437001941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437001942 ATP binding site [chemical binding]; other site 511437001943 Mg2+ binding site [ion binding]; other site 511437001944 G-X-G motif; other site 511437001945 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 511437001946 Competence protein CoiA-like family; Region: CoiA; cl11541 511437001947 oligoendopeptidase F; Region: pepF; TIGR00181 511437001948 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 511437001949 active site 511437001950 Zn binding site [ion binding]; other site 511437001951 Thioredoxin; Region: Thioredoxin_5; pfam13743 511437001952 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 511437001953 synthetase active site [active] 511437001954 NTP binding site [chemical binding]; other site 511437001955 metal binding site [ion binding]; metal-binding site 511437001956 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 511437001957 ATP-NAD kinase; Region: NAD_kinase; pfam01513 511437001958 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 511437001959 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 511437001960 active site 511437001961 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 511437001962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437001963 S-adenosylmethionine binding site [chemical binding]; other site 511437001964 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 511437001965 TRF-binding motif region of TRF-Interacting Nuclear factor 2; Region: TIN2_TBM; cd11741 511437001966 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 511437001967 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 511437001968 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 511437001969 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 511437001970 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 511437001971 cell division protein MraZ; Reviewed; Region: PRK00326 511437001972 MraZ protein; Region: MraZ; pfam02381 511437001973 MraZ protein; Region: MraZ; pfam02381 511437001974 MraW methylase family; Region: Methyltransf_5; pfam01795 511437001975 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 511437001976 Cell division protein FtsL; Region: FtsL; cl11433 511437001977 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 511437001978 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 511437001979 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 511437001980 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 511437001981 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 511437001982 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 511437001983 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 511437001984 Mg++ binding site [ion binding]; other site 511437001985 putative catalytic motif [active] 511437001986 putative substrate binding site [chemical binding]; other site 511437001987 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 511437001988 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 511437001989 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511437001990 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511437001991 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 511437001992 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 511437001993 active site 511437001994 homodimer interface [polypeptide binding]; other site 511437001995 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 511437001996 Cell division protein FtsQ; Region: FtsQ; pfam03799 511437001997 cell division protein FtsA; Region: ftsA; TIGR01174 511437001998 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511437001999 nucleotide binding site [chemical binding]; other site 511437002000 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 511437002001 Cell division protein FtsA; Region: FtsA; pfam14450 511437002002 cell division protein FtsZ; Validated; Region: PRK09330 511437002003 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 511437002004 nucleotide binding site [chemical binding]; other site 511437002005 SulA interaction site; other site 511437002006 Protein of unknown function (DUF552); Region: DUF552; cl00775 511437002007 YGGT family; Region: YGGT; pfam02325 511437002008 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 511437002009 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511437002010 RNA binding surface [nucleotide binding]; other site 511437002011 DivIVA protein; Region: DivIVA; pfam05103 511437002012 DivIVA domain; Region: DivI1A_domain; TIGR03544 511437002013 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 511437002014 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511437002015 active site 511437002016 HIGH motif; other site 511437002017 nucleotide binding site [chemical binding]; other site 511437002018 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 511437002019 active site 511437002020 KMSKS motif; other site 511437002021 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 511437002022 tRNA binding surface [nucleotide binding]; other site 511437002023 anticodon binding site; other site 511437002024 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 511437002025 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 511437002026 DNA-binding site [nucleotide binding]; DNA binding site 511437002027 RNA-binding motif; other site 511437002028 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 511437002029 dimer interface [polypeptide binding]; other site 511437002030 ADP-ribose binding site [chemical binding]; other site 511437002031 active site 511437002032 nudix motif; other site 511437002033 metal binding site [ion binding]; metal-binding site 511437002034 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 511437002035 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 511437002036 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 511437002037 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 511437002038 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511437002039 catalytic residue [active] 511437002040 Putative amino acid metabolism; Region: DUF1831; pfam08866 511437002041 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 511437002042 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 511437002043 homodimer interface [polypeptide binding]; other site 511437002044 substrate-cofactor binding pocket; other site 511437002045 catalytic residue [active] 511437002046 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 511437002047 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 511437002048 homodimer interface [polypeptide binding]; other site 511437002049 substrate-cofactor binding pocket; other site 511437002050 catalytic residue [active] 511437002051 histidinol-phosphatase; Reviewed; Region: PRK08123 511437002052 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 511437002053 active site 511437002054 dimer interface [polypeptide binding]; other site 511437002055 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 511437002056 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 511437002057 dimer interface [polypeptide binding]; other site 511437002058 motif 1; other site 511437002059 active site 511437002060 motif 2; other site 511437002061 motif 3; other site 511437002062 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 511437002063 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 511437002064 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 511437002065 putative active site pocket [active] 511437002066 4-fold oligomerization interface [polypeptide binding]; other site 511437002067 metal binding residues [ion binding]; metal-binding site 511437002068 3-fold/trimer interface [polypeptide binding]; other site 511437002069 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 511437002070 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 511437002071 putative active site [active] 511437002072 oxyanion strand; other site 511437002073 catalytic triad [active] 511437002074 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 511437002075 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 511437002076 catalytic residues [active] 511437002077 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 511437002078 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 511437002079 substrate binding site [chemical binding]; other site 511437002080 glutamase interaction surface [polypeptide binding]; other site 511437002081 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 511437002082 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 511437002083 metal binding site [ion binding]; metal-binding site 511437002084 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 511437002085 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437002086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437002087 homodimer interface [polypeptide binding]; other site 511437002088 catalytic residue [active] 511437002089 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 511437002090 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 511437002091 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437002092 catalytic core [active] 511437002093 Tetratricopeptide repeat; Region: TPR_12; pfam13424 511437002094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511437002095 binding surface 511437002096 TPR motif; other site 511437002097 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 511437002098 binding surface 511437002099 TPR motif; other site 511437002100 TPR repeat; Region: TPR_11; pfam13414 511437002101 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 511437002102 AAA domain; Region: AAA_30; pfam13604 511437002103 Family description; Region: UvrD_C_2; pfam13538 511437002104 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 511437002105 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 511437002106 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437002107 active site 511437002108 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437002109 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437002110 active site 511437002111 catalytic tetrad [active] 511437002112 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511437002113 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437002114 DNA binding site [nucleotide binding] 511437002115 domain linker motif; other site 511437002116 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 511437002117 dimerization interface [polypeptide binding]; other site 511437002118 ligand binding site [chemical binding]; other site 511437002119 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 511437002120 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 511437002121 substrate binding site [chemical binding]; other site 511437002122 dimer interface [polypeptide binding]; other site 511437002123 ATP binding site [chemical binding]; other site 511437002124 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 511437002125 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 511437002126 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 511437002127 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 511437002128 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 511437002129 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 511437002130 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 511437002131 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437002132 non-specific DNA binding site [nucleotide binding]; other site 511437002133 salt bridge; other site 511437002134 sequence-specific DNA binding site [nucleotide binding]; other site 511437002135 H+ Antiporter protein; Region: 2A0121; TIGR00900 511437002136 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 511437002137 active site 511437002138 catalytic residues [active] 511437002139 metal binding site [ion binding]; metal-binding site 511437002140 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 511437002141 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 511437002142 TPP-binding site [chemical binding]; other site 511437002143 heterodimer interface [polypeptide binding]; other site 511437002144 tetramer interface [polypeptide binding]; other site 511437002145 phosphorylation loop region [posttranslational modification] 511437002146 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 511437002147 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 511437002148 alpha subunit interface [polypeptide binding]; other site 511437002149 TPP binding site [chemical binding]; other site 511437002150 heterodimer interface [polypeptide binding]; other site 511437002151 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 511437002152 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 511437002153 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 511437002154 E3 interaction surface; other site 511437002155 lipoyl attachment site [posttranslational modification]; other site 511437002156 e3 binding domain; Region: E3_binding; pfam02817 511437002157 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 511437002158 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 511437002159 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 511437002160 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511437002161 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 511437002162 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 511437002163 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 511437002164 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 511437002165 active site 511437002166 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 511437002167 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 511437002168 G1 box; other site 511437002169 putative GEF interaction site [polypeptide binding]; other site 511437002170 GTP/Mg2+ binding site [chemical binding]; other site 511437002171 Switch I region; other site 511437002172 G2 box; other site 511437002173 G3 box; other site 511437002174 Switch II region; other site 511437002175 G4 box; other site 511437002176 G5 box; other site 511437002177 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 511437002178 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 511437002179 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 511437002180 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 511437002181 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 511437002182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437002183 S-adenosylmethionine binding site [chemical binding]; other site 511437002184 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 511437002185 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 511437002186 active site 511437002187 (T/H)XGH motif; other site 511437002188 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 511437002189 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 511437002190 protein binding site [polypeptide binding]; other site 511437002191 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 511437002192 SLBB domain; Region: SLBB; pfam10531 511437002193 comEA protein; Region: comE; TIGR01259 511437002194 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 511437002195 catalytic motif [active] 511437002196 Zn binding site [ion binding]; other site 511437002197 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 511437002198 Competence protein; Region: Competence; pfam03772 511437002199 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 511437002200 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 511437002201 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 511437002202 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 511437002203 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 511437002204 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 511437002205 16S/18S rRNA binding site [nucleotide binding]; other site 511437002206 S13e-L30e interaction site [polypeptide binding]; other site 511437002207 25S rRNA binding site [nucleotide binding]; other site 511437002208 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 511437002209 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 511437002210 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 511437002211 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 511437002212 elongation factor Tu; Reviewed; Region: PRK00049 511437002213 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 511437002214 G1 box; other site 511437002215 GEF interaction site [polypeptide binding]; other site 511437002216 GTP/Mg2+ binding site [chemical binding]; other site 511437002217 Switch I region; other site 511437002218 G2 box; other site 511437002219 G3 box; other site 511437002220 Switch II region; other site 511437002221 G4 box; other site 511437002222 G5 box; other site 511437002223 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 511437002224 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 511437002225 Antibiotic Binding Site [chemical binding]; other site 511437002226 trigger factor; Provisional; Region: tig; PRK01490 511437002227 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 511437002228 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 511437002229 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 511437002230 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 511437002231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437002232 Walker A motif; other site 511437002233 ATP binding site [chemical binding]; other site 511437002234 Walker B motif; other site 511437002235 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 511437002236 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 511437002237 G1 box; other site 511437002238 GTP/Mg2+ binding site [chemical binding]; other site 511437002239 Switch I region; other site 511437002240 G2 box; other site 511437002241 G3 box; other site 511437002242 Switch II region; other site 511437002243 G4 box; other site 511437002244 G5 box; other site 511437002245 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 511437002246 putative metal binding site [ion binding]; other site 511437002247 argininosuccinate synthase; Provisional; Region: PRK13820 511437002248 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 511437002249 ANP binding site [chemical binding]; other site 511437002250 Substrate Binding Site II [chemical binding]; other site 511437002251 Substrate Binding Site I [chemical binding]; other site 511437002252 argininosuccinate lyase; Provisional; Region: PRK00855 511437002253 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 511437002254 active sites [active] 511437002255 tetramer interface [polypeptide binding]; other site 511437002256 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511437002257 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511437002258 substrate binding pocket [chemical binding]; other site 511437002259 membrane-bound complex binding site; other site 511437002260 hinge residues; other site 511437002261 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511437002262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437002263 dimer interface [polypeptide binding]; other site 511437002264 conserved gate region; other site 511437002265 putative PBP binding loops; other site 511437002266 ABC-ATPase subunit interface; other site 511437002267 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511437002268 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 511437002269 Walker A/P-loop; other site 511437002270 ATP binding site [chemical binding]; other site 511437002271 Q-loop/lid; other site 511437002272 ABC transporter signature motif; other site 511437002273 Walker B; other site 511437002274 D-loop; other site 511437002275 H-loop/switch region; other site 511437002276 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 511437002277 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 511437002278 GIY-YIG motif/motif A; other site 511437002279 active site 511437002280 catalytic site [active] 511437002281 putative DNA binding site [nucleotide binding]; other site 511437002282 metal binding site [ion binding]; metal-binding site 511437002283 UvrB/uvrC motif; Region: UVR; pfam02151 511437002284 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 511437002285 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 511437002286 DNA binding site [nucleotide binding] 511437002287 GTPase CgtA; Reviewed; Region: obgE; PRK12297 511437002288 GTP1/OBG; Region: GTP1_OBG; pfam01018 511437002289 Obg GTPase; Region: Obg; cd01898 511437002290 G1 box; other site 511437002291 GTP/Mg2+ binding site [chemical binding]; other site 511437002292 Switch I region; other site 511437002293 G2 box; other site 511437002294 G3 box; other site 511437002295 Switch II region; other site 511437002296 G4 box; other site 511437002297 G5 box; other site 511437002298 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 511437002299 Acyltransferase family; Region: Acyl_transf_3; pfam01757 511437002300 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 511437002301 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 511437002302 catalytic triad [active] 511437002303 catalytic triad [active] 511437002304 oxyanion hole [active] 511437002305 ribonuclease Z; Region: RNase_Z; TIGR02651 511437002306 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 511437002307 DHH family; Region: DHH; pfam01368 511437002308 DHHA1 domain; Region: DHHA1; pfam02272 511437002309 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 511437002310 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437002311 active site 511437002312 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 511437002313 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 511437002314 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 511437002315 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 511437002316 RNA binding site [nucleotide binding]; other site 511437002317 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 511437002318 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437002319 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437002320 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511437002321 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 511437002322 Walker A/P-loop; other site 511437002323 ATP binding site [chemical binding]; other site 511437002324 Q-loop/lid; other site 511437002325 ABC transporter signature motif; other site 511437002326 Walker B; other site 511437002327 D-loop; other site 511437002328 H-loop/switch region; other site 511437002329 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511437002330 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511437002331 substrate binding pocket [chemical binding]; other site 511437002332 membrane-bound complex binding site; other site 511437002333 hinge residues; other site 511437002334 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511437002335 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511437002336 substrate binding pocket [chemical binding]; other site 511437002337 membrane-bound complex binding site; other site 511437002338 hinge residues; other site 511437002339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437002340 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511437002341 dimer interface [polypeptide binding]; other site 511437002342 conserved gate region; other site 511437002343 putative PBP binding loops; other site 511437002344 ABC-ATPase subunit interface; other site 511437002345 transaminase; Reviewed; Region: PRK08068 511437002346 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437002347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437002348 homodimer interface [polypeptide binding]; other site 511437002349 catalytic residue [active] 511437002350 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 511437002351 active site 511437002352 DNA polymerase IV; Reviewed; Region: PRK03103 511437002353 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 511437002354 active site 511437002355 DNA binding site [nucleotide binding] 511437002356 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 511437002357 maltose O-acetyltransferase; Provisional; Region: PRK10092 511437002358 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 511437002359 active site 511437002360 substrate binding site [chemical binding]; other site 511437002361 trimer interface [polypeptide binding]; other site 511437002362 CoA binding site [chemical binding]; other site 511437002363 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 511437002364 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 511437002365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437002366 Coenzyme A binding pocket [chemical binding]; other site 511437002367 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 511437002368 putative deacylase active site [active] 511437002369 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 511437002370 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 511437002371 Tic20-like protein; Region: Tic20; pfam09685 511437002372 MMPL family; Region: MMPL; pfam03176 511437002373 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 511437002374 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511437002375 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511437002376 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 511437002377 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 511437002378 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 511437002379 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 511437002380 amidase catalytic site [active] 511437002381 Zn binding residues [ion binding]; other site 511437002382 substrate binding site [chemical binding]; other site 511437002383 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 511437002384 Aspartase; Region: Aspartase; cd01357 511437002385 active sites [active] 511437002386 tetramer interface [polypeptide binding]; other site 511437002387 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 511437002388 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 511437002389 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437002390 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 511437002391 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437002392 motif II; other site 511437002393 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 511437002394 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511437002395 MarR family; Region: MarR; pfam01047 511437002396 MarR family; Region: MarR_2; cl17246 511437002397 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 511437002398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437002399 Coenzyme A binding pocket [chemical binding]; other site 511437002400 B3/4 domain; Region: B3_4; smart00873 511437002401 B3/4 domain; Region: B3_4; pfam03483 511437002402 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 511437002403 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 511437002404 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 511437002405 trimer interface [polypeptide binding]; other site 511437002406 active site 511437002407 substrate binding site [chemical binding]; other site 511437002408 CoA binding site [chemical binding]; other site 511437002409 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 511437002410 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 511437002411 NAD binding site [chemical binding]; other site 511437002412 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 511437002413 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 511437002414 catalytic Zn binding site [ion binding]; other site 511437002415 NAD binding site [chemical binding]; other site 511437002416 structural Zn binding site [ion binding]; other site 511437002417 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 511437002418 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 511437002419 NAD binding site [chemical binding]; other site 511437002420 catalytic residues [active] 511437002421 substrate binding site [chemical binding]; other site 511437002422 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 511437002423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437002424 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437002425 putative substrate translocation pore; other site 511437002426 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 511437002427 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 511437002428 putative active site [active] 511437002429 putative FMN binding site [chemical binding]; other site 511437002430 putative substrate binding site [chemical binding]; other site 511437002431 putative catalytic residue [active] 511437002432 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 511437002433 FMN binding site [chemical binding]; other site 511437002434 dimer interface [polypeptide binding]; other site 511437002435 Peptidase family C69; Region: Peptidase_C69; pfam03577 511437002436 phosphoenolpyruvate carboxylase; Provisional; Region: PRK13655 511437002437 phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751 511437002438 Uncharacterized conserved protein [Function unknown]; Region: COG1359 511437002439 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 511437002440 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 511437002441 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 511437002442 nucleotide binding site/active site [active] 511437002443 HIT family signature motif; other site 511437002444 catalytic residue [active] 511437002445 VanZ like family; Region: VanZ; pfam04892 511437002446 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 511437002447 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 511437002448 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 511437002449 peptidase domain interface [polypeptide binding]; other site 511437002450 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 511437002451 active site 511437002452 catalytic triad [active] 511437002453 calcium binding site [ion binding]; other site 511437002454 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 511437002455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437002456 putative substrate translocation pore; other site 511437002457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437002458 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 511437002459 active site 511437002460 motif I; other site 511437002461 motif II; other site 511437002462 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 511437002463 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 511437002464 putative active site [active] 511437002465 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511437002466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511437002467 active site 511437002468 phosphorylation site [posttranslational modification] 511437002469 intermolecular recognition site; other site 511437002470 dimerization interface [polypeptide binding]; other site 511437002471 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511437002472 DNA binding site [nucleotide binding] 511437002473 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 511437002474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 511437002475 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511437002476 dimerization interface [polypeptide binding]; other site 511437002477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511437002478 dimer interface [polypeptide binding]; other site 511437002479 phosphorylation site [posttranslational modification] 511437002480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437002481 ATP binding site [chemical binding]; other site 511437002482 Mg2+ binding site [ion binding]; other site 511437002483 G-X-G motif; other site 511437002484 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 511437002485 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 511437002486 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 511437002487 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 511437002488 Protein of unknown function (DUF419); Region: DUF419; pfam04237 511437002489 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 511437002490 Beta-lactamase; Region: Beta-lactamase; pfam00144 511437002491 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 511437002492 catalytic triad [active] 511437002493 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 511437002494 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511437002495 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 511437002496 thymidine kinase; Provisional; Region: PRK04296 511437002497 peptide chain release factor 1; Validated; Region: prfA; PRK00591 511437002498 This domain is found in peptide chain release factors; Region: PCRF; smart00937 511437002499 RF-1 domain; Region: RF-1; pfam00472 511437002500 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 511437002501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437002502 S-adenosylmethionine binding site [chemical binding]; other site 511437002503 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 511437002504 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 511437002505 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 511437002506 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 511437002507 dimer interface [polypeptide binding]; other site 511437002508 active site 511437002509 glycine-pyridoxal phosphate binding site [chemical binding]; other site 511437002510 folate binding site [chemical binding]; other site 511437002511 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437002512 active site 511437002513 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 511437002514 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 511437002515 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 511437002516 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 511437002517 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 511437002518 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 511437002519 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 511437002520 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 511437002521 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 511437002522 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 511437002523 beta subunit interaction interface [polypeptide binding]; other site 511437002524 Walker A motif; other site 511437002525 ATP binding site [chemical binding]; other site 511437002526 Walker B motif; other site 511437002527 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 511437002528 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 511437002529 core domain interface [polypeptide binding]; other site 511437002530 delta subunit interface [polypeptide binding]; other site 511437002531 epsilon subunit interface [polypeptide binding]; other site 511437002532 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 511437002533 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 511437002534 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 511437002535 alpha subunit interaction interface [polypeptide binding]; other site 511437002536 Walker A motif; other site 511437002537 ATP binding site [chemical binding]; other site 511437002538 Walker B motif; other site 511437002539 inhibitor binding site; inhibition site 511437002540 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 511437002541 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 511437002542 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 511437002543 gamma subunit interface [polypeptide binding]; other site 511437002544 epsilon subunit interface [polypeptide binding]; other site 511437002545 LBP interface [polypeptide binding]; other site 511437002546 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 511437002547 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 511437002548 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 511437002549 hinge; other site 511437002550 active site 511437002551 rod shape-determining protein MreB; Provisional; Region: PRK13930 511437002552 MreB and similar proteins; Region: MreB_like; cd10225 511437002553 nucleotide binding site [chemical binding]; other site 511437002554 Mg binding site [ion binding]; other site 511437002555 putative protofilament interaction site [polypeptide binding]; other site 511437002556 RodZ interaction site [polypeptide binding]; other site 511437002557 Haemolytic domain; Region: Haemolytic; pfam01809 511437002558 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 511437002559 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 511437002560 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 511437002561 lipoyl attachment site [posttranslational modification]; other site 511437002562 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 511437002563 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 511437002564 Walker A/P-loop; other site 511437002565 ATP binding site [chemical binding]; other site 511437002566 Q-loop/lid; other site 511437002567 ABC transporter signature motif; other site 511437002568 Walker B; other site 511437002569 D-loop; other site 511437002570 H-loop/switch region; other site 511437002571 NIL domain; Region: NIL; pfam09383 511437002572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437002573 dimer interface [polypeptide binding]; other site 511437002574 conserved gate region; other site 511437002575 ABC-ATPase subunit interface; other site 511437002576 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 511437002577 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 511437002578 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 511437002579 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 511437002580 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511437002581 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 511437002582 Walker A/P-loop; other site 511437002583 ATP binding site [chemical binding]; other site 511437002584 Q-loop/lid; other site 511437002585 ABC transporter signature motif; other site 511437002586 Walker B; other site 511437002587 D-loop; other site 511437002588 H-loop/switch region; other site 511437002589 Predicted transcriptional regulators [Transcription]; Region: COG1725 511437002590 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511437002591 DNA-binding site [nucleotide binding]; DNA binding site 511437002592 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 511437002593 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 511437002594 Walker A/P-loop; other site 511437002595 ATP binding site [chemical binding]; other site 511437002596 Q-loop/lid; other site 511437002597 ABC transporter signature motif; other site 511437002598 Walker B; other site 511437002599 D-loop; other site 511437002600 H-loop/switch region; other site 511437002601 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 511437002602 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 511437002603 ATP-grasp domain; Region: ATP-grasp_4; cl17255 511437002604 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 511437002605 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 511437002606 active site 511437002607 catalytic site [active] 511437002608 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 511437002609 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511437002610 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437002611 non-specific DNA binding site [nucleotide binding]; other site 511437002612 salt bridge; other site 511437002613 sequence-specific DNA binding site [nucleotide binding]; other site 511437002614 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511437002615 Ligand Binding Site [chemical binding]; other site 511437002616 recombination factor protein RarA; Reviewed; Region: PRK13342 511437002617 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437002618 Walker A motif; other site 511437002619 ATP binding site [chemical binding]; other site 511437002620 Walker B motif; other site 511437002621 arginine finger; other site 511437002622 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 511437002623 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 511437002624 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 511437002625 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511437002626 RNA binding surface [nucleotide binding]; other site 511437002627 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 511437002628 GAF domain; Region: GAF_2; pfam13185 511437002629 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 511437002630 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 511437002631 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 511437002632 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511437002633 catalytic residue [active] 511437002634 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 511437002635 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 511437002636 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 511437002637 Ligand Binding Site [chemical binding]; other site 511437002638 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 511437002639 dimer interface [polypeptide binding]; other site 511437002640 catalytic triad [active] 511437002641 peroxidatic and resolving cysteines [active] 511437002642 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 511437002643 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511437002644 active site 511437002645 HIGH motif; other site 511437002646 nucleotide binding site [chemical binding]; other site 511437002647 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 511437002648 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 511437002649 active site 511437002650 KMSKS motif; other site 511437002651 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 511437002652 tRNA binding surface [nucleotide binding]; other site 511437002653 anticodon binding site; other site 511437002654 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 511437002655 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 511437002656 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511437002657 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511437002658 rod shape-determining protein MreB; Provisional; Region: PRK13927 511437002659 MreB and similar proteins; Region: MreB_like; cd10225 511437002660 nucleotide binding site [chemical binding]; other site 511437002661 Mg binding site [ion binding]; other site 511437002662 putative protofilament interaction site [polypeptide binding]; other site 511437002663 RodZ interaction site [polypeptide binding]; other site 511437002664 rod shape-determining protein MreC; Provisional; Region: PRK13922 511437002665 rod shape-determining protein MreC; Region: MreC; pfam04085 511437002666 rod shape-determining protein MreD; Region: MreD; cl01087 511437002667 septum formation inhibitor; Reviewed; Region: minC; PRK00513 511437002668 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 511437002669 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 511437002670 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 511437002671 Switch I; other site 511437002672 Switch II; other site 511437002673 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511437002674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437002675 dimer interface [polypeptide binding]; other site 511437002676 conserved gate region; other site 511437002677 putative PBP binding loops; other site 511437002678 ABC-ATPase subunit interface; other site 511437002679 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511437002680 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437002681 Walker A/P-loop; other site 511437002682 ATP binding site [chemical binding]; other site 511437002683 Q-loop/lid; other site 511437002684 ABC transporter signature motif; other site 511437002685 Walker B; other site 511437002686 D-loop; other site 511437002687 H-loop/switch region; other site 511437002688 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511437002689 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511437002690 substrate binding pocket [chemical binding]; other site 511437002691 membrane-bound complex binding site; other site 511437002692 hinge residues; other site 511437002693 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 511437002694 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 511437002695 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 511437002696 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 511437002697 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 511437002698 Helix-turn-helix domain; Region: HTH_25; pfam13413 511437002699 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 511437002700 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 511437002701 Competence-damaged protein; Region: CinA; pfam02464 511437002702 recombinase A; Provisional; Region: recA; PRK09354 511437002703 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 511437002704 hexamer interface [polypeptide binding]; other site 511437002705 Walker A motif; other site 511437002706 ATP binding site [chemical binding]; other site 511437002707 Walker B motif; other site 511437002708 phosphodiesterase; Provisional; Region: PRK12704 511437002709 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511437002710 Zn2+ binding site [ion binding]; other site 511437002711 Mg2+ binding site [ion binding]; other site 511437002712 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 511437002713 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 511437002714 putative active site [active] 511437002715 metal binding site [ion binding]; metal-binding site 511437002716 homodimer binding site [polypeptide binding]; other site 511437002717 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 511437002718 MutS domain I; Region: MutS_I; pfam01624 511437002719 MutS domain II; Region: MutS_II; pfam05188 511437002720 MutS domain III; Region: MutS_III; pfam05192 511437002721 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 511437002722 Walker A/P-loop; other site 511437002723 ATP binding site [chemical binding]; other site 511437002724 Q-loop/lid; other site 511437002725 ABC transporter signature motif; other site 511437002726 Walker B; other site 511437002727 D-loop; other site 511437002728 H-loop/switch region; other site 511437002729 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 511437002730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437002731 ATP binding site [chemical binding]; other site 511437002732 Mg2+ binding site [ion binding]; other site 511437002733 G-X-G motif; other site 511437002734 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 511437002735 ATP binding site [chemical binding]; other site 511437002736 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 511437002737 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 511437002738 RuvA N terminal domain; Region: RuvA_N; pfam01330 511437002739 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 511437002740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437002741 Walker A motif; other site 511437002742 ATP binding site [chemical binding]; other site 511437002743 Walker B motif; other site 511437002744 arginine finger; other site 511437002745 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 511437002746 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 511437002747 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 511437002748 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 511437002749 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 511437002750 Preprotein translocase subunit; Region: YajC; pfam02699 511437002751 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 511437002752 active site 511437002753 DNA polymerase IV; Validated; Region: PRK02406 511437002754 DNA binding site [nucleotide binding] 511437002755 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 511437002756 DHH family; Region: DHH; pfam01368 511437002757 DHHA1 domain; Region: DHHA1; pfam02272 511437002758 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 511437002759 DEAD-like helicases superfamily; Region: DEXDc; smart00487 511437002760 ATP binding site [chemical binding]; other site 511437002761 Mg++ binding site [ion binding]; other site 511437002762 motif III; other site 511437002763 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437002764 nucleotide binding region [chemical binding]; other site 511437002765 ATP-binding site [chemical binding]; other site 511437002766 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 511437002767 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 511437002768 motif 1; other site 511437002769 active site 511437002770 motif 2; other site 511437002771 motif 3; other site 511437002772 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 511437002773 DHHA1 domain; Region: DHHA1; pfam02272 511437002774 hypothetical protein; Provisional; Region: PRK05473 511437002775 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 511437002776 hypothetical protein; Provisional; Region: PRK13678 511437002777 Cell division protein ZapA; Region: ZapA; pfam05164 511437002778 Colicin V production protein; Region: Colicin_V; pfam02674 511437002779 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 511437002780 MutS domain III; Region: MutS_III; pfam05192 511437002781 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 511437002782 Walker A/P-loop; other site 511437002783 ATP binding site [chemical binding]; other site 511437002784 Q-loop/lid; other site 511437002785 ABC transporter signature motif; other site 511437002786 Walker B; other site 511437002787 D-loop; other site 511437002788 H-loop/switch region; other site 511437002789 Domain of unknown function DUF148; Region: DUF148; pfam02520 511437002790 Smr domain; Region: Smr; pfam01713 511437002791 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 511437002792 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 511437002793 catalytic residues [active] 511437002794 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437002795 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437002796 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 511437002797 glutamate racemase; Provisional; Region: PRK00865 511437002798 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 511437002799 active site 511437002800 dimerization interface [polypeptide binding]; other site 511437002801 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 511437002802 active site 511437002803 metal binding site [ion binding]; metal-binding site 511437002804 homotetramer interface [polypeptide binding]; other site 511437002805 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 511437002806 FOG: CBS domain [General function prediction only]; Region: COG0517 511437002807 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 511437002808 Mechanosensitive ion channel; Region: MS_channel; pfam00924 511437002809 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 511437002810 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 511437002811 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 511437002812 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 511437002813 active site 511437002814 catabolite control protein A; Region: ccpA; TIGR01481 511437002815 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437002816 DNA binding site [nucleotide binding] 511437002817 domain linker motif; other site 511437002818 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 511437002819 dimerization interface [polypeptide binding]; other site 511437002820 effector binding site; other site 511437002821 hypothetical protein; Validated; Region: PRK00110 511437002822 Type II/IV secretion system protein; Region: T2SE; pfam00437 511437002823 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 511437002824 Walker A motif; other site 511437002825 ATP binding site [chemical binding]; other site 511437002826 Walker B motif; other site 511437002827 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 511437002828 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 511437002829 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 511437002830 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 511437002831 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 511437002832 Methyltransferase domain; Region: Methyltransf_26; pfam13659 511437002833 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 511437002834 propionate/acetate kinase; Provisional; Region: PRK12379 511437002835 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 511437002836 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 511437002837 putative active site [active] 511437002838 putative metal binding site [ion binding]; other site 511437002839 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 511437002840 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 511437002841 active site 511437002842 metal binding site [ion binding]; metal-binding site 511437002843 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 511437002844 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 511437002845 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 511437002846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437002847 active site 511437002848 motif I; other site 511437002849 motif II; other site 511437002850 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437002851 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 511437002852 PspC domain; Region: PspC; pfam04024 511437002853 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 511437002854 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 511437002855 dimer interface [polypeptide binding]; other site 511437002856 active site 511437002857 LexA repressor; Validated; Region: PRK00215 511437002858 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511437002859 putative DNA binding site [nucleotide binding]; other site 511437002860 putative Zn2+ binding site [ion binding]; other site 511437002861 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 511437002862 Catalytic site [active] 511437002863 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 511437002864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 511437002865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437002866 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437002867 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 511437002868 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 511437002869 putative acyl-acceptor binding pocket; other site 511437002870 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 511437002871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437002872 S-adenosylmethionine binding site [chemical binding]; other site 511437002873 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 511437002874 GIY-YIG motif/motif A; other site 511437002875 putative active site [active] 511437002876 putative metal binding site [ion binding]; other site 511437002877 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 511437002878 D-lactate dehydrogenase; Validated; Region: PRK08605 511437002879 homodimer interface [polypeptide binding]; other site 511437002880 ligand binding site [chemical binding]; other site 511437002881 NAD binding site [chemical binding]; other site 511437002882 catalytic site [active] 511437002883 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437002884 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437002885 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 511437002886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437002887 motif II; other site 511437002888 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 511437002889 rRNA interaction site [nucleotide binding]; other site 511437002890 S8 interaction site; other site 511437002891 putative laminin-1 binding site; other site 511437002892 elongation factor Ts; Provisional; Region: tsf; PRK09377 511437002893 UBA/TS-N domain; Region: UBA; pfam00627 511437002894 Elongation factor TS; Region: EF_TS; pfam00889 511437002895 Elongation factor TS; Region: EF_TS; pfam00889 511437002896 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 511437002897 putative nucleotide binding site [chemical binding]; other site 511437002898 uridine monophosphate binding site [chemical binding]; other site 511437002899 homohexameric interface [polypeptide binding]; other site 511437002900 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 511437002901 ribosome recycling factor; Reviewed; Region: frr; PRK00083 511437002902 hinge region; other site 511437002903 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 511437002904 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 511437002905 catalytic residue [active] 511437002906 putative FPP diphosphate binding site; other site 511437002907 putative FPP binding hydrophobic cleft; other site 511437002908 dimer interface [polypeptide binding]; other site 511437002909 putative IPP diphosphate binding site; other site 511437002910 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 511437002911 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 511437002912 RIP metalloprotease RseP; Region: TIGR00054 511437002913 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 511437002914 active site 511437002915 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 511437002916 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 511437002917 protein binding site [polypeptide binding]; other site 511437002918 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 511437002919 prolyl-tRNA synthetase; Provisional; Region: PRK09194 511437002920 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 511437002921 dimer interface [polypeptide binding]; other site 511437002922 motif 1; other site 511437002923 active site 511437002924 motif 2; other site 511437002925 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 511437002926 putative deacylase active site [active] 511437002927 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 511437002928 active site 511437002929 motif 3; other site 511437002930 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 511437002931 anticodon binding site; other site 511437002932 DNA polymerase III PolC; Validated; Region: polC; PRK00448 511437002933 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 511437002934 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 511437002935 generic binding surface I; other site 511437002936 generic binding surface II; other site 511437002937 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 511437002938 active site 511437002939 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 511437002940 active site 511437002941 catalytic site [active] 511437002942 substrate binding site [chemical binding]; other site 511437002943 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 511437002944 ribosome maturation protein RimP; Reviewed; Region: PRK00092 511437002945 Sm and related proteins; Region: Sm_like; cl00259 511437002946 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 511437002947 putative oligomer interface [polypeptide binding]; other site 511437002948 putative RNA binding site [nucleotide binding]; other site 511437002949 transcription termination factor NusA; Region: NusA; TIGR01953 511437002950 NusA N-terminal domain; Region: NusA_N; pfam08529 511437002951 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 511437002952 RNA binding site [nucleotide binding]; other site 511437002953 homodimer interface [polypeptide binding]; other site 511437002954 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 511437002955 G-X-X-G motif; other site 511437002956 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 511437002957 G-X-X-G motif; other site 511437002958 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 511437002959 putative RNA binding cleft [nucleotide binding]; other site 511437002960 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 511437002961 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 511437002962 translation initiation factor IF-2; Region: IF-2; TIGR00487 511437002963 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 511437002964 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 511437002965 G1 box; other site 511437002966 putative GEF interaction site [polypeptide binding]; other site 511437002967 GTP/Mg2+ binding site [chemical binding]; other site 511437002968 Switch I region; other site 511437002969 G2 box; other site 511437002970 G3 box; other site 511437002971 Switch II region; other site 511437002972 G4 box; other site 511437002973 G5 box; other site 511437002974 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 511437002975 Translation-initiation factor 2; Region: IF-2; pfam11987 511437002976 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 511437002977 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 511437002978 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 511437002979 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 511437002980 RNA binding site [nucleotide binding]; other site 511437002981 active site 511437002982 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 511437002983 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 511437002984 active site 511437002985 Riboflavin kinase; Region: Flavokinase; smart00904 511437002986 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 511437002987 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 511437002988 GrpE; Region: GrpE; pfam01025 511437002989 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 511437002990 dimer interface [polypeptide binding]; other site 511437002991 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 511437002992 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 511437002993 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 511437002994 nucleotide binding site [chemical binding]; other site 511437002995 chaperone protein DnaJ; Provisional; Region: PRK14276 511437002996 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 511437002997 HSP70 interaction site [polypeptide binding]; other site 511437002998 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 511437002999 substrate binding site [polypeptide binding]; other site 511437003000 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 511437003001 Zn binding sites [ion binding]; other site 511437003002 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 511437003003 dimer interface [polypeptide binding]; other site 511437003004 GTP-binding protein LepA; Provisional; Region: PRK05433 511437003005 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 511437003006 G1 box; other site 511437003007 putative GEF interaction site [polypeptide binding]; other site 511437003008 GTP/Mg2+ binding site [chemical binding]; other site 511437003009 Switch I region; other site 511437003010 G2 box; other site 511437003011 G3 box; other site 511437003012 Switch II region; other site 511437003013 G4 box; other site 511437003014 G5 box; other site 511437003015 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 511437003016 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 511437003017 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 511437003018 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 511437003019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437003020 S-adenosylmethionine binding site [chemical binding]; other site 511437003021 RNA methyltransferase, RsmE family; Region: TIGR00046 511437003022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 511437003023 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 511437003024 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511437003025 Zn2+ binding site [ion binding]; other site 511437003026 Mg2+ binding site [ion binding]; other site 511437003027 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 511437003028 synthetase active site [active] 511437003029 NTP binding site [chemical binding]; other site 511437003030 metal binding site [ion binding]; metal-binding site 511437003031 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 511437003032 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 511437003033 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 511437003034 putative active site [active] 511437003035 dimerization interface [polypeptide binding]; other site 511437003036 putative tRNAtyr binding site [nucleotide binding]; other site 511437003037 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 511437003038 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437003039 motif II; other site 511437003040 Bacterial SH3 domain; Region: SH3_3; pfam08239 511437003041 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 511437003042 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 511437003043 active site 511437003044 metal binding site [ion binding]; metal-binding site 511437003045 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 511437003046 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 511437003047 dimer interface [polypeptide binding]; other site 511437003048 motif 1; other site 511437003049 active site 511437003050 motif 2; other site 511437003051 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 511437003052 anticodon binding site; other site 511437003053 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 511437003054 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 511437003055 dimer interface [polypeptide binding]; other site 511437003056 anticodon binding site; other site 511437003057 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 511437003058 homodimer interface [polypeptide binding]; other site 511437003059 motif 1; other site 511437003060 active site 511437003061 motif 2; other site 511437003062 GAD domain; Region: GAD; pfam02938 511437003063 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 511437003064 active site 511437003065 motif 3; other site 511437003066 Uncharacterized conserved protein [Function unknown]; Region: COG1284 511437003067 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 511437003068 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 511437003069 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 511437003070 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 511437003071 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 511437003072 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 511437003073 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 511437003074 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 511437003075 endonuclease IV; Provisional; Region: PRK01060 511437003076 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 511437003077 AP (apurinic/apyrimidinic) site pocket; other site 511437003078 DNA interaction; other site 511437003079 Metal-binding active site; metal-binding site 511437003080 PEP synthetase regulatory protein; Provisional; Region: PRK05339 511437003081 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 511437003082 Yqey-like protein; Region: YqeY; pfam09424 511437003083 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 511437003084 PhoH-like protein; Region: PhoH; pfam02562 511437003085 metal-binding heat shock protein; Provisional; Region: PRK00016 511437003086 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 511437003087 GTPase Era; Reviewed; Region: era; PRK00089 511437003088 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 511437003089 G1 box; other site 511437003090 GTP/Mg2+ binding site [chemical binding]; other site 511437003091 Switch I region; other site 511437003092 G2 box; other site 511437003093 Switch II region; other site 511437003094 G3 box; other site 511437003095 G4 box; other site 511437003096 G5 box; other site 511437003097 KH domain; Region: KH_2; pfam07650 511437003098 DNA repair protein RecO; Region: reco; TIGR00613 511437003099 Recombination protein O N terminal; Region: RecO_N; pfam11967 511437003100 Recombination protein O C terminal; Region: RecO_C; pfam02565 511437003101 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 511437003102 dimer interface [polypeptide binding]; other site 511437003103 motif 1; other site 511437003104 active site 511437003105 motif 2; other site 511437003106 motif 3; other site 511437003107 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 511437003108 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 511437003109 DNA primase, catalytic core; Region: dnaG; TIGR01391 511437003110 CHC2 zinc finger; Region: zf-CHC2; pfam01807 511437003111 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 511437003112 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 511437003113 active site 511437003114 metal binding site [ion binding]; metal-binding site 511437003115 interdomain interaction site; other site 511437003116 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 511437003117 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 511437003118 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 511437003119 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511437003120 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 511437003121 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511437003122 DNA binding residues [nucleotide binding] 511437003123 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 511437003124 Family of unknown function (DUF633); Region: DUF633; pfam04816 511437003125 Uncharacterized conserved protein [Function unknown]; Region: COG0327 511437003126 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 511437003127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 511437003128 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 511437003129 Uncharacterized conserved protein [Function unknown]; Region: COG0327 511437003130 peptidase T; Region: peptidase-T; TIGR01882 511437003131 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 511437003132 metal binding site [ion binding]; metal-binding site 511437003133 dimer interface [polypeptide binding]; other site 511437003134 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 511437003135 Clp amino terminal domain; Region: Clp_N; pfam02861 511437003136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437003137 Walker A motif; other site 511437003138 ATP binding site [chemical binding]; other site 511437003139 Walker B motif; other site 511437003140 arginine finger; other site 511437003141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437003142 Walker A motif; other site 511437003143 ATP binding site [chemical binding]; other site 511437003144 Walker B motif; other site 511437003145 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 511437003146 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 511437003147 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 511437003148 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 511437003149 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 511437003150 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 511437003151 active site 511437003152 PHP Thumb interface [polypeptide binding]; other site 511437003153 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 511437003154 generic binding surface I; other site 511437003155 generic binding surface II; other site 511437003156 pyruvate kinase; Provisional; Region: PRK06354 511437003157 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 511437003158 domain interfaces; other site 511437003159 active site 511437003160 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 511437003161 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 511437003162 S1 domain; Region: S1_2; pfam13509 511437003163 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 511437003164 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 511437003165 active site 511437003166 Int/Topo IB signature motif; other site 511437003167 ScpA/B protein; Region: ScpA_ScpB; cl00598 511437003168 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 511437003169 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 511437003170 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511437003171 RNA binding surface [nucleotide binding]; other site 511437003172 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 511437003173 active site 511437003174 Predicted membrane protein [Function unknown]; Region: COG3601 511437003175 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 511437003176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 511437003177 DEAD-like helicases superfamily; Region: DEXDc; smart00487 511437003178 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511437003179 ATP binding site [chemical binding]; other site 511437003180 putative Mg++ binding site [ion binding]; other site 511437003181 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437003182 nucleotide binding region [chemical binding]; other site 511437003183 ATP-binding site [chemical binding]; other site 511437003184 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 511437003185 cytidylate kinase; Provisional; Region: cmk; PRK00023 511437003186 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 511437003187 CMP-binding site; other site 511437003188 The sites determining sugar specificity; other site 511437003189 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 511437003190 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 511437003191 RNA binding site [nucleotide binding]; other site 511437003192 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 511437003193 RNA binding site [nucleotide binding]; other site 511437003194 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 511437003195 RNA binding site [nucleotide binding]; other site 511437003196 GTP-binding protein Der; Reviewed; Region: PRK00093 511437003197 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 511437003198 G1 box; other site 511437003199 GTP/Mg2+ binding site [chemical binding]; other site 511437003200 Switch I region; other site 511437003201 G2 box; other site 511437003202 Switch II region; other site 511437003203 G3 box; other site 511437003204 G4 box; other site 511437003205 G5 box; other site 511437003206 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 511437003207 G1 box; other site 511437003208 GTP/Mg2+ binding site [chemical binding]; other site 511437003209 Switch I region; other site 511437003210 G2 box; other site 511437003211 G3 box; other site 511437003212 Switch II region; other site 511437003213 G4 box; other site 511437003214 G5 box; other site 511437003215 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 511437003216 IHF dimer interface [polypeptide binding]; other site 511437003217 IHF - DNA interface [nucleotide binding]; other site 511437003218 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511437003219 binding surface 511437003220 TPR motif; other site 511437003221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511437003222 TPR motif; other site 511437003223 binding surface 511437003224 TPR repeat; Region: TPR_11; pfam13414 511437003225 Tetratricopeptide repeat; Region: TPR_16; pfam13432 511437003226 Uncharacterized conserved protein [Function unknown]; Region: COG1284 511437003227 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 511437003228 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 511437003229 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 511437003230 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 511437003231 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 511437003232 active site 511437003233 NTP binding site [chemical binding]; other site 511437003234 metal binding triad [ion binding]; metal-binding site 511437003235 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 511437003236 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 511437003237 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 511437003238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437003239 Walker A/P-loop; other site 511437003240 ATP binding site [chemical binding]; other site 511437003241 Q-loop/lid; other site 511437003242 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511437003243 ABC transporter signature motif; other site 511437003244 Walker B; other site 511437003245 D-loop; other site 511437003246 ABC transporter; Region: ABC_tran_2; pfam12848 511437003247 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511437003248 thymidylate synthase; Region: thym_sym; TIGR03284 511437003249 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 511437003250 dimerization interface [polypeptide binding]; other site 511437003251 active site 511437003252 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 511437003253 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 511437003254 folate binding site [chemical binding]; other site 511437003255 NADP+ binding site [chemical binding]; other site 511437003256 EDD domain protein, DegV family; Region: DegV; TIGR00762 511437003257 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 511437003258 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 511437003259 active site 511437003260 catalytic triad [active] 511437003261 oxyanion hole [active] 511437003262 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 511437003263 hypothetical protein; Provisional; Region: PRK13672 511437003264 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 511437003265 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 511437003266 GTP/Mg2+ binding site [chemical binding]; other site 511437003267 G4 box; other site 511437003268 G5 box; other site 511437003269 G1 box; other site 511437003270 Switch I region; other site 511437003271 G2 box; other site 511437003272 G3 box; other site 511437003273 Switch II region; other site 511437003274 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 511437003275 RNA/DNA hybrid binding site [nucleotide binding]; other site 511437003276 active site 511437003277 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 511437003278 DNA protecting protein DprA; Region: dprA; TIGR00732 511437003279 DNA topoisomerase I; Validated; Region: PRK05582 511437003280 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 511437003281 active site 511437003282 interdomain interaction site; other site 511437003283 putative metal-binding site [ion binding]; other site 511437003284 nucleotide binding site [chemical binding]; other site 511437003285 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 511437003286 domain I; other site 511437003287 DNA binding groove [nucleotide binding] 511437003288 phosphate binding site [ion binding]; other site 511437003289 domain II; other site 511437003290 domain III; other site 511437003291 nucleotide binding site [chemical binding]; other site 511437003292 catalytic site [active] 511437003293 domain IV; other site 511437003294 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 511437003295 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 511437003296 Peptidase family C69; Region: Peptidase_C69; pfam03577 511437003297 Peptidase family C69; Region: Peptidase_C69; pfam03577 511437003298 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 511437003299 active site 1 [active] 511437003300 dimer interface [polypeptide binding]; other site 511437003301 hexamer interface [polypeptide binding]; other site 511437003302 active site 2 [active] 511437003303 glycerol kinase; Provisional; Region: glpK; PRK00047 511437003304 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 511437003305 N- and C-terminal domain interface [polypeptide binding]; other site 511437003306 active site 511437003307 MgATP binding site [chemical binding]; other site 511437003308 catalytic site [active] 511437003309 metal binding site [ion binding]; metal-binding site 511437003310 glycerol binding site [chemical binding]; other site 511437003311 homotetramer interface [polypeptide binding]; other site 511437003312 homodimer interface [polypeptide binding]; other site 511437003313 FBP binding site [chemical binding]; other site 511437003314 protein IIAGlc interface [polypeptide binding]; other site 511437003315 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437003316 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 511437003317 active site 511437003318 motif I; other site 511437003319 motif II; other site 511437003320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 511437003321 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 511437003322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437003323 S-adenosylmethionine binding site [chemical binding]; other site 511437003324 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 511437003325 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 511437003326 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 511437003327 homotetramer interface [polypeptide binding]; other site 511437003328 FMN binding site [chemical binding]; other site 511437003329 homodimer contacts [polypeptide binding]; other site 511437003330 putative active site [active] 511437003331 putative substrate binding site [chemical binding]; other site 511437003332 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 511437003333 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511437003334 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 511437003335 diphosphomevalonate decarboxylase; Region: PLN02407 511437003336 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 511437003337 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511437003338 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 511437003339 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 511437003340 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 511437003341 active site 511437003342 catalytic site [active] 511437003343 substrate binding site [chemical binding]; other site 511437003344 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 511437003345 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 511437003346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 511437003347 aspartate aminotransferase; Provisional; Region: PRK05764 511437003348 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437003349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437003350 homodimer interface [polypeptide binding]; other site 511437003351 catalytic residue [active] 511437003352 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 511437003353 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 511437003354 putative dimer interface [polypeptide binding]; other site 511437003355 putative anticodon binding site; other site 511437003356 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 511437003357 homodimer interface [polypeptide binding]; other site 511437003358 motif 1; other site 511437003359 motif 2; other site 511437003360 active site 511437003361 motif 3; other site 511437003362 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 511437003363 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 511437003364 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 511437003365 Transglycosylase; Region: Transgly; pfam00912 511437003366 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 511437003367 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 511437003368 hypothetical protein; Provisional; Region: PRK13660 511437003369 cell division protein GpsB; Provisional; Region: PRK14127 511437003370 DivIVA domain; Region: DivI1A_domain; TIGR03544 511437003371 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 511437003372 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 511437003373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 511437003374 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 511437003375 RNA/DNA hybrid binding site [nucleotide binding]; other site 511437003376 active site 511437003377 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 511437003378 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 511437003379 Potassium binding sites [ion binding]; other site 511437003380 Cesium cation binding sites [ion binding]; other site 511437003381 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 511437003382 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 511437003383 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511437003384 RNA binding surface [nucleotide binding]; other site 511437003385 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 511437003386 active site 511437003387 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 511437003388 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437003389 active site 511437003390 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 511437003391 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 511437003392 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 511437003393 catalytic site [active] 511437003394 subunit interface [polypeptide binding]; other site 511437003395 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 511437003396 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 511437003397 ATP-grasp domain; Region: ATP-grasp_4; cl17255 511437003398 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 511437003399 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 511437003400 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 511437003401 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 511437003402 Domain of unknown function (DUF814); Region: DUF814; pfam05670 511437003403 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511437003404 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 511437003405 EDD domain protein, DegV family; Region: DegV; TIGR00762 511437003406 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 511437003407 hypothetical protein; Provisional; Region: PRK09609 511437003408 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 511437003409 active site 511437003410 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 511437003411 catalytic center binding site [active] 511437003412 ATP binding site [chemical binding]; other site 511437003413 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 511437003414 GTP cyclohydrolase I; Provisional; Region: PLN03044 511437003415 active site 511437003416 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 511437003417 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511437003418 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511437003419 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 511437003420 dihydropteroate synthase; Region: DHPS; TIGR01496 511437003421 substrate binding pocket [chemical binding]; other site 511437003422 dimer interface [polypeptide binding]; other site 511437003423 inhibitor binding site; inhibition site 511437003424 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 511437003425 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511437003426 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 511437003427 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 511437003428 nudix motif; other site 511437003429 putative acetyltransferase; Provisional; Region: PRK03624 511437003430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437003431 Coenzyme A binding pocket [chemical binding]; other site 511437003432 LicD family; Region: LicD; cl01378 511437003433 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 511437003434 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 511437003435 active site 511437003436 DNA binding site [nucleotide binding] 511437003437 Int/Topo IB signature motif; other site 511437003438 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 511437003439 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 511437003440 minor groove reading motif; other site 511437003441 helix-hairpin-helix signature motif; other site 511437003442 substrate binding pocket [chemical binding]; other site 511437003443 active site 511437003444 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 511437003445 DNA binding and oxoG recognition site [nucleotide binding] 511437003446 methionine sulfoxide reductase A; Provisional; Region: PRK14054 511437003447 methionine sulfoxide reductase B; Provisional; Region: PRK00222 511437003448 SelR domain; Region: SelR; pfam01641 511437003449 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 511437003450 DHH family; Region: DHH; pfam01368 511437003451 DHHA2 domain; Region: DHHA2; pfam02833 511437003452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511437003453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511437003454 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 511437003455 dimerization interface [polypeptide binding]; other site 511437003456 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 511437003457 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 511437003458 CAP-like domain; other site 511437003459 active site 511437003460 primary dimer interface [polypeptide binding]; other site 511437003461 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511437003462 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 511437003463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437003464 ATP binding site [chemical binding]; other site 511437003465 Mg2+ binding site [ion binding]; other site 511437003466 G-X-G motif; other site 511437003467 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 511437003468 anchoring element; other site 511437003469 dimer interface [polypeptide binding]; other site 511437003470 ATP binding site [chemical binding]; other site 511437003471 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 511437003472 active site 511437003473 putative metal-binding site [ion binding]; other site 511437003474 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 511437003475 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 511437003476 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 511437003477 active site 511437003478 catalytic residues [active] 511437003479 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 511437003480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437003481 Walker A motif; other site 511437003482 ATP binding site [chemical binding]; other site 511437003483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437003484 Walker B motif; other site 511437003485 arginine finger; other site 511437003486 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 511437003487 ATP-dependent protease subunit HslV; Provisional; Region: PRK05456 511437003488 active site 511437003489 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 511437003490 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 511437003491 active site 511437003492 DNA binding site [nucleotide binding] 511437003493 Int/Topo IB signature motif; other site 511437003494 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 511437003495 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 511437003496 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 511437003497 RimM N-terminal domain; Region: RimM; pfam01782 511437003498 PRC-barrel domain; Region: PRC; pfam05239 511437003499 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 511437003500 KH domain; Region: KH_4; pfam13083 511437003501 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 511437003502 signal recognition particle protein; Provisional; Region: PRK10867 511437003503 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 511437003504 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 511437003505 P loop; other site 511437003506 GTP binding site [chemical binding]; other site 511437003507 Signal peptide binding domain; Region: SRP_SPB; pfam02978 511437003508 putative DNA-binding protein; Validated; Region: PRK00118 511437003509 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 511437003510 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 511437003511 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 511437003512 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 511437003513 P loop; other site 511437003514 GTP binding site [chemical binding]; other site 511437003515 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 511437003516 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 511437003517 Walker A/P-loop; other site 511437003518 ATP binding site [chemical binding]; other site 511437003519 Q-loop/lid; other site 511437003520 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 511437003521 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 511437003522 ABC transporter signature motif; other site 511437003523 Walker B; other site 511437003524 D-loop; other site 511437003525 H-loop/switch region; other site 511437003526 ribonuclease III; Reviewed; Region: rnc; PRK00102 511437003527 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 511437003528 dimerization interface [polypeptide binding]; other site 511437003529 active site 511437003530 metal binding site [ion binding]; metal-binding site 511437003531 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 511437003532 acyl carrier protein; Provisional; Region: acpP; PRK00982 511437003533 putative phosphate acyltransferase; Provisional; Region: PRK05331 511437003534 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 511437003535 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 511437003536 generic binding surface II; other site 511437003537 ssDNA binding site; other site 511437003538 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511437003539 ATP binding site [chemical binding]; other site 511437003540 putative Mg++ binding site [ion binding]; other site 511437003541 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437003542 nucleotide binding region [chemical binding]; other site 511437003543 ATP-binding site [chemical binding]; other site 511437003544 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 511437003545 DAK2 domain; Region: Dak2; pfam02734 511437003546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 511437003547 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 511437003548 Thiamine pyrophosphokinase; Region: TPK; cd07995 511437003549 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 511437003550 active site 511437003551 dimerization interface [polypeptide binding]; other site 511437003552 thiamine binding site [chemical binding]; other site 511437003553 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 511437003554 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 511437003555 substrate binding site [chemical binding]; other site 511437003556 hexamer interface [polypeptide binding]; other site 511437003557 metal binding site [ion binding]; metal-binding site 511437003558 GTPase RsgA; Reviewed; Region: PRK00098 511437003559 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 511437003560 RNA binding site [nucleotide binding]; other site 511437003561 homodimer interface [polypeptide binding]; other site 511437003562 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 511437003563 GTPase/Zn-binding domain interface [polypeptide binding]; other site 511437003564 GTP/Mg2+ binding site [chemical binding]; other site 511437003565 G4 box; other site 511437003566 G5 box; other site 511437003567 G1 box; other site 511437003568 Switch I region; other site 511437003569 G2 box; other site 511437003570 G3 box; other site 511437003571 Switch II region; other site 511437003572 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 511437003573 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 511437003574 active site 511437003575 ATP binding site [chemical binding]; other site 511437003576 substrate binding site [chemical binding]; other site 511437003577 activation loop (A-loop); other site 511437003578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 511437003579 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 511437003580 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 511437003581 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 511437003582 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 511437003583 Protein phosphatase 2C; Region: PP2C; pfam00481 511437003584 active site 511437003585 16S rRNA methyltransferase B; Provisional; Region: PRK14902 511437003586 NusB family; Region: NusB; pfam01029 511437003587 putative RNA binding site [nucleotide binding]; other site 511437003588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437003589 S-adenosylmethionine binding site [chemical binding]; other site 511437003590 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 511437003591 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 511437003592 putative active site [active] 511437003593 substrate binding site [chemical binding]; other site 511437003594 putative cosubstrate binding site; other site 511437003595 catalytic site [active] 511437003596 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 511437003597 substrate binding site [chemical binding]; other site 511437003598 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 511437003599 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511437003600 ATP binding site [chemical binding]; other site 511437003601 putative Mg++ binding site [ion binding]; other site 511437003602 FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764 511437003603 Zn binding sites [ion binding]; other site 511437003604 phosphatidylinositol 3-phosphate binding site [chemical binding]; other site 511437003605 helicase superfamily c-terminal domain; Region: HELICc; smart00490 511437003606 ATP-binding site [chemical binding]; other site 511437003607 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 511437003608 Flavoprotein; Region: Flavoprotein; pfam02441 511437003609 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 511437003610 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 511437003611 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 511437003612 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 511437003613 catalytic site [active] 511437003614 G-X2-G-X-G-K; other site 511437003615 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 511437003616 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 511437003617 Walker A/P-loop; other site 511437003618 ATP binding site [chemical binding]; other site 511437003619 Q-loop/lid; other site 511437003620 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 511437003621 ABC transporter signature motif; other site 511437003622 Walker B; other site 511437003623 D-loop; other site 511437003624 H-loop/switch region; other site 511437003625 Arginine repressor [Transcription]; Region: ArgR; COG1438 511437003626 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 511437003627 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 511437003628 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 511437003629 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511437003630 RNA binding surface [nucleotide binding]; other site 511437003631 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 511437003632 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 511437003633 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 511437003634 substrate binding pocket [chemical binding]; other site 511437003635 chain length determination region; other site 511437003636 substrate-Mg2+ binding site; other site 511437003637 catalytic residues [active] 511437003638 aspartate-rich region 1; other site 511437003639 active site lid residues [active] 511437003640 aspartate-rich region 2; other site 511437003641 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 511437003642 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 511437003643 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 511437003644 generic binding surface II; other site 511437003645 generic binding surface I; other site 511437003646 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 511437003647 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 511437003648 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 511437003649 homodimer interface [polypeptide binding]; other site 511437003650 NADP binding site [chemical binding]; other site 511437003651 substrate binding site [chemical binding]; other site 511437003652 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 511437003653 putative RNA binding site [nucleotide binding]; other site 511437003654 Asp23 family; Region: Asp23; pfam03780 511437003655 elongation factor P; Validated; Region: PRK00529 511437003656 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 511437003657 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 511437003658 RNA binding site [nucleotide binding]; other site 511437003659 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 511437003660 RNA binding site [nucleotide binding]; other site 511437003661 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 511437003662 Protein of unknown function (DUF464); Region: DUF464; pfam04327 511437003663 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 511437003664 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 511437003665 dUTPase; Region: dUTPase_2; pfam08761 511437003666 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 511437003667 active site 511437003668 homodimer interface [polypeptide binding]; other site 511437003669 metal binding site [ion binding]; metal-binding site 511437003670 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 511437003671 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511437003672 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511437003673 peptide binding site [polypeptide binding]; other site 511437003674 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 511437003675 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 511437003676 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 511437003677 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 511437003678 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 511437003679 DNA binding residues [nucleotide binding] 511437003680 putative dimer interface [polypeptide binding]; other site 511437003681 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 511437003682 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 511437003683 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 511437003684 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 511437003685 active site 511437003686 catalytic site [active] 511437003687 metal binding site [ion binding]; metal-binding site 511437003688 dimer interface [polypeptide binding]; other site 511437003689 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 511437003690 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 511437003691 active site residue [active] 511437003692 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 511437003693 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511437003694 nucleotide binding site [chemical binding]; other site 511437003695 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 511437003696 Rhomboid family; Region: Rhomboid; pfam01694 511437003697 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 511437003698 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 511437003699 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 511437003700 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 511437003701 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 511437003702 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 511437003703 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 511437003704 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 511437003705 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 511437003706 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437003707 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437003708 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 511437003709 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 511437003710 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 511437003711 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 511437003712 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 511437003713 Sugar specificity; other site 511437003714 Pyrimidine base specificity; other site 511437003715 ATP-binding site [chemical binding]; other site 511437003716 YceG-like family; Region: YceG; pfam02618 511437003717 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 511437003718 dimerization interface [polypeptide binding]; other site 511437003719 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 511437003720 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 511437003721 putative tRNA-binding site [nucleotide binding]; other site 511437003722 B3/4 domain; Region: B3_4; pfam03483 511437003723 tRNA synthetase B5 domain; Region: B5; smart00874 511437003724 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 511437003725 dimer interface [polypeptide binding]; other site 511437003726 motif 1; other site 511437003727 motif 3; other site 511437003728 motif 2; other site 511437003729 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 511437003730 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 511437003731 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 511437003732 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 511437003733 dimer interface [polypeptide binding]; other site 511437003734 motif 1; other site 511437003735 active site 511437003736 motif 2; other site 511437003737 motif 3; other site 511437003738 Predicted transcriptional regulators [Transcription]; Region: COG1733 511437003739 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 511437003740 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 511437003741 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 511437003742 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 511437003743 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 511437003744 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 511437003745 OxaA-like protein precursor; Provisional; Region: PRK02463 511437003746 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 511437003747 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 511437003748 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 511437003749 TrkA-N domain; Region: TrkA_N; pfam02254 511437003750 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 511437003751 TrkA-C domain; Region: TrkA_C; pfam02080 511437003752 Helix-turn-helix domain; Region: HTH_38; pfam13936 511437003753 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437003754 Integrase core domain; Region: rve; pfam00665 511437003755 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437003756 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 511437003757 Walker A motif; other site 511437003758 ATP binding site [chemical binding]; other site 511437003759 Walker B motif; other site 511437003760 arginine finger; other site 511437003761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437003762 Walker A motif; other site 511437003763 ATP binding site [chemical binding]; other site 511437003764 Walker B motif; other site 511437003765 arginine finger; other site 511437003766 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 511437003767 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437003768 Integrase core domain; Region: rve; pfam00665 511437003769 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 511437003770 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 511437003771 Cl binding site [ion binding]; other site 511437003772 oligomer interface [polypeptide binding]; other site 511437003773 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 511437003774 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511437003775 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 511437003776 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 511437003777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511437003778 dimerization interface [polypeptide binding]; other site 511437003779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511437003780 dimer interface [polypeptide binding]; other site 511437003781 phosphorylation site [posttranslational modification] 511437003782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437003783 ATP binding site [chemical binding]; other site 511437003784 Mg2+ binding site [ion binding]; other site 511437003785 G-X-G motif; other site 511437003786 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511437003787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511437003788 active site 511437003789 phosphorylation site [posttranslational modification] 511437003790 intermolecular recognition site; other site 511437003791 dimerization interface [polypeptide binding]; other site 511437003792 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511437003793 DNA binding site [nucleotide binding] 511437003794 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 511437003795 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 511437003796 NAD binding site [chemical binding]; other site 511437003797 substrate binding site [chemical binding]; other site 511437003798 catalytic Zn binding site [ion binding]; other site 511437003799 tetramer interface [polypeptide binding]; other site 511437003800 structural Zn binding site [ion binding]; other site 511437003801 Helix-turn-helix domain; Region: HTH_38; pfam13936 511437003802 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437003803 Integrase core domain; Region: rve; pfam00665 511437003804 Integrase core domain; Region: rve_3; cl15866 511437003805 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 511437003806 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 511437003807 hypothetical protein; Provisional; Region: PRK13670 511437003808 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 511437003809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437003810 S-adenosylmethionine binding site [chemical binding]; other site 511437003811 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 511437003812 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511437003813 Zn2+ binding site [ion binding]; other site 511437003814 Mg2+ binding site [ion binding]; other site 511437003815 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 511437003816 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 511437003817 active site 511437003818 (T/H)XGH motif; other site 511437003819 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 511437003820 GTPase YqeH; Provisional; Region: PRK13796 511437003821 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 511437003822 GTP/Mg2+ binding site [chemical binding]; other site 511437003823 G4 box; other site 511437003824 G5 box; other site 511437003825 G1 box; other site 511437003826 Switch I region; other site 511437003827 G2 box; other site 511437003828 G3 box; other site 511437003829 Switch II region; other site 511437003830 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 511437003831 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437003832 active site 511437003833 motif I; other site 511437003834 motif II; other site 511437003835 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 511437003836 23S rRNA binding site [nucleotide binding]; other site 511437003837 L21 binding site [polypeptide binding]; other site 511437003838 L13 binding site [polypeptide binding]; other site 511437003839 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 511437003840 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 511437003841 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 511437003842 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 511437003843 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 511437003844 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 511437003845 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 511437003846 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 511437003847 active site 511437003848 dimer interface [polypeptide binding]; other site 511437003849 motif 1; other site 511437003850 motif 2; other site 511437003851 motif 3; other site 511437003852 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 511437003853 anticodon binding site; other site 511437003854 primosomal protein DnaI; Reviewed; Region: PRK08939 511437003855 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 511437003856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437003857 Walker A motif; other site 511437003858 ATP binding site [chemical binding]; other site 511437003859 Walker B motif; other site 511437003860 arginine finger; other site 511437003861 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 511437003862 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 511437003863 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 511437003864 ATP cone domain; Region: ATP-cone; pfam03477 511437003865 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 511437003866 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 511437003867 CoA-binding site [chemical binding]; other site 511437003868 ATP-binding [chemical binding]; other site 511437003869 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 511437003870 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 511437003871 DNA binding site [nucleotide binding] 511437003872 catalytic residue [active] 511437003873 H2TH interface [polypeptide binding]; other site 511437003874 putative catalytic residues [active] 511437003875 turnover-facilitating residue; other site 511437003876 intercalation triad [nucleotide binding]; other site 511437003877 8OG recognition residue [nucleotide binding]; other site 511437003878 putative reading head residues; other site 511437003879 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 511437003880 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 511437003881 DNA polymerase I; Provisional; Region: PRK05755 511437003882 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 511437003883 active site 511437003884 metal binding site 1 [ion binding]; metal-binding site 511437003885 putative 5' ssDNA interaction site; other site 511437003886 metal binding site 3; metal-binding site 511437003887 metal binding site 2 [ion binding]; metal-binding site 511437003888 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 511437003889 putative DNA binding site [nucleotide binding]; other site 511437003890 putative metal binding site [ion binding]; other site 511437003891 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 511437003892 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 511437003893 active site 511437003894 DNA binding site [nucleotide binding] 511437003895 catalytic site [active] 511437003896 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 511437003897 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 511437003898 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 511437003899 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511437003900 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511437003901 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511437003902 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 511437003903 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 511437003904 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 511437003905 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 511437003906 putative tRNA-binding site [nucleotide binding]; other site 511437003907 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 511437003908 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 511437003909 catalytic residues [active] 511437003910 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 511437003911 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 511437003912 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 511437003913 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 511437003914 Walker A/P-loop; other site 511437003915 ATP binding site [chemical binding]; other site 511437003916 Q-loop/lid; other site 511437003917 ABC transporter signature motif; other site 511437003918 Walker B; other site 511437003919 D-loop; other site 511437003920 H-loop/switch region; other site 511437003921 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 511437003922 HIT family signature motif; other site 511437003923 catalytic residue [active] 511437003924 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 511437003925 SurA N-terminal domain; Region: SurA_N_3; cl07813 511437003926 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 511437003927 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437003928 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437003929 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 511437003930 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 511437003931 generic binding surface I; other site 511437003932 generic binding surface II; other site 511437003933 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 511437003934 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511437003935 Zn2+ binding site [ion binding]; other site 511437003936 Mg2+ binding site [ion binding]; other site 511437003937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437003938 Walker A/P-loop; other site 511437003939 ATP binding site [chemical binding]; other site 511437003940 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 511437003941 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 511437003942 active site 511437003943 metal binding site [ion binding]; metal-binding site 511437003944 DNA binding site [nucleotide binding] 511437003945 Protein of unknown function (DUF964); Region: DUF964; cl01483 511437003946 Transglycosylase; Region: Transgly; pfam00912 511437003947 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 511437003948 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 511437003949 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 511437003950 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 511437003951 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 511437003952 active site 511437003953 HIGH motif; other site 511437003954 KMSK motif region; other site 511437003955 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 511437003956 tRNA binding surface [nucleotide binding]; other site 511437003957 anticodon binding site; other site 511437003958 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 511437003959 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 511437003960 aspartate racemase; Region: asp_race; TIGR00035 511437003961 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 511437003962 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 511437003963 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 511437003964 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511437003965 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511437003966 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511437003967 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 511437003968 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 511437003969 active site 511437003970 dimer interface [polypeptide binding]; other site 511437003971 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 511437003972 Ligand Binding Site [chemical binding]; other site 511437003973 Molecular Tunnel; other site 511437003974 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511437003975 Ligand Binding Site [chemical binding]; other site 511437003976 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 511437003977 peptidase domain interface [polypeptide binding]; other site 511437003978 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 511437003979 active site 511437003980 catalytic triad [active] 511437003981 calcium binding site [ion binding]; other site 511437003982 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511437003983 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511437003984 putative Zn2+ binding site [ion binding]; other site 511437003985 putative DNA binding site [nucleotide binding]; other site 511437003986 MarR family; Region: MarR_2; cl17246 511437003987 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 511437003988 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 511437003989 NlpC/P60 family; Region: NLPC_P60; pfam00877 511437003990 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 511437003991 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 511437003992 active site 511437003993 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511437003994 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511437003995 peptide binding site [polypeptide binding]; other site 511437003996 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 511437003997 putative active site [active] 511437003998 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 511437003999 homodimer interface [polypeptide binding]; other site 511437004000 homotetramer interface [polypeptide binding]; other site 511437004001 active site pocket [active] 511437004002 cleavage site 511437004003 CAAX protease self-immunity; Region: Abi; pfam02517 511437004004 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 511437004005 peptidase domain interface [polypeptide binding]; other site 511437004006 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 511437004007 active site 511437004008 catalytic triad [active] 511437004009 calcium binding site [ion binding]; other site 511437004010 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 511437004011 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 511437004012 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 511437004013 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 511437004014 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 511437004015 beta-phosphoglucomutase; Region: bPGM; TIGR01990 511437004016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437004017 motif II; other site 511437004018 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 511437004019 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437004020 active site 511437004021 motif I; other site 511437004022 motif II; other site 511437004023 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 511437004024 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 511437004025 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 511437004026 Substrate-binding site [chemical binding]; other site 511437004027 Substrate specificity [chemical binding]; other site 511437004028 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 511437004029 Protein of unknown function; Region: DUF3658; pfam12395 511437004030 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437004031 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437004032 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511437004033 Ligand Binding Site [chemical binding]; other site 511437004034 dipeptidase PepV; Reviewed; Region: PRK07318 511437004035 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 511437004036 active site 511437004037 metal binding site [ion binding]; metal-binding site 511437004038 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 511437004039 putative substrate binding site [chemical binding]; other site 511437004040 putative ATP binding site [chemical binding]; other site 511437004041 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 511437004042 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 511437004043 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 511437004044 Acyltransferase family; Region: Acyl_transf_3; pfam01757 511437004045 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 511437004046 DNA translocase FtsK; Provisional; Region: PRK10263 511437004047 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 511437004048 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 511437004049 HIGH motif; other site 511437004050 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 511437004051 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 511437004052 active site 511437004053 KMSKS motif; other site 511437004054 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 511437004055 tRNA binding surface [nucleotide binding]; other site 511437004056 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 511437004057 active site 511437004058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437004059 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437004060 putative substrate translocation pore; other site 511437004061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437004062 S-adenosylmethionine synthetase; Validated; Region: PRK05250 511437004063 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 511437004064 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 511437004065 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 511437004066 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 511437004067 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 511437004068 Cl binding site [ion binding]; other site 511437004069 oligomer interface [polypeptide binding]; other site 511437004070 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 511437004071 Isochorismatase family; Region: Isochorismatase; pfam00857 511437004072 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 511437004073 catalytic triad [active] 511437004074 conserved cis-peptide bond; other site 511437004075 Asp23 family; Region: Asp23; pfam03780 511437004076 Asp23 family; Region: Asp23; pfam03780 511437004077 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 511437004078 Uncharacterized conserved protein [Function unknown]; Region: COG1434 511437004079 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 511437004080 putative active site [active] 511437004081 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511437004082 MarR family; Region: MarR_2; pfam12802 511437004083 LicD family; Region: LicD; pfam04991 511437004084 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 511437004085 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 511437004086 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 511437004087 Walker A/P-loop; other site 511437004088 ATP binding site [chemical binding]; other site 511437004089 Q-loop/lid; other site 511437004090 ABC transporter signature motif; other site 511437004091 Walker B; other site 511437004092 D-loop; other site 511437004093 H-loop/switch region; other site 511437004094 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 511437004095 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 511437004096 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 511437004097 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 511437004098 glutaminase active site [active] 511437004099 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 511437004100 dimer interface [polypeptide binding]; other site 511437004101 active site 511437004102 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 511437004103 dimer interface [polypeptide binding]; other site 511437004104 active site 511437004105 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 511437004106 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 511437004107 active site 511437004108 substrate binding site [chemical binding]; other site 511437004109 metal binding site [ion binding]; metal-binding site 511437004110 YbbR-like protein; Region: YbbR; pfam07949 511437004111 YbbR-like protein; Region: YbbR; pfam07949 511437004112 Uncharacterized conserved protein [Function unknown]; Region: COG1624 511437004113 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 511437004114 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 511437004115 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 511437004116 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 511437004117 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 511437004118 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 511437004119 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 511437004120 FAD binding domain; Region: FAD_binding_4; pfam01565 511437004121 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 511437004122 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 511437004123 active site 511437004124 catalytic site [active] 511437004125 substrate binding site [chemical binding]; other site 511437004126 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 511437004127 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 511437004128 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 511437004129 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 511437004130 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 511437004131 ligand binding site [chemical binding]; other site 511437004132 active site 511437004133 UGI interface [polypeptide binding]; other site 511437004134 catalytic site [active] 511437004135 Tubby C 2; Region: Tub_2; cl02043 511437004136 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 511437004137 SmpB-tmRNA interface; other site 511437004138 ribonuclease R; Region: RNase_R; TIGR02063 511437004139 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 511437004140 RNB domain; Region: RNB; pfam00773 511437004141 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 511437004142 RNA binding site [nucleotide binding]; other site 511437004143 Esterase/lipase [General function prediction only]; Region: COG1647 511437004144 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 511437004145 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 511437004146 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 511437004147 Cl- selectivity filter; other site 511437004148 Cl- binding residues [ion binding]; other site 511437004149 pore gating glutamate residue; other site 511437004150 dimer interface [polypeptide binding]; other site 511437004151 H+/Cl- coupling transport residue; other site 511437004152 TrkA-C domain; Region: TrkA_C; pfam02080 511437004153 enolase; Provisional; Region: eno; PRK00077 511437004154 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 511437004155 dimer interface [polypeptide binding]; other site 511437004156 metal binding site [ion binding]; metal-binding site 511437004157 substrate binding pocket [chemical binding]; other site 511437004158 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 511437004159 triosephosphate isomerase; Provisional; Region: PRK14565 511437004160 substrate binding site [chemical binding]; other site 511437004161 dimer interface [polypeptide binding]; other site 511437004162 catalytic triad [active] 511437004163 Phosphoglycerate kinase; Region: PGK; pfam00162 511437004164 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 511437004165 substrate binding site [chemical binding]; other site 511437004166 hinge regions; other site 511437004167 ADP binding site [chemical binding]; other site 511437004168 catalytic site [active] 511437004169 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 511437004170 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 511437004171 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 511437004172 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 511437004173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437004174 Coenzyme A binding pocket [chemical binding]; other site 511437004175 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 511437004176 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 511437004177 Zn binding site [ion binding]; other site 511437004178 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 511437004179 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 511437004180 Zn binding site [ion binding]; other site 511437004181 Clp protease; Region: CLP_protease; pfam00574 511437004182 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 511437004183 oligomer interface [polypeptide binding]; other site 511437004184 active site residues [active] 511437004185 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 511437004186 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 511437004187 putative NAD(P) binding site [chemical binding]; other site 511437004188 putative substrate binding site [chemical binding]; other site 511437004189 catalytic Zn binding site [ion binding]; other site 511437004190 structural Zn binding site [ion binding]; other site 511437004191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 511437004192 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 511437004193 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 511437004194 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 511437004195 phosphate binding site [ion binding]; other site 511437004196 putative substrate binding pocket [chemical binding]; other site 511437004197 dimer interface [polypeptide binding]; other site 511437004198 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 511437004199 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 511437004200 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 511437004201 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 511437004202 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 511437004203 excinuclease ABC subunit B; Provisional; Region: PRK05298 511437004204 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511437004205 ATP binding site [chemical binding]; other site 511437004206 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437004207 nucleotide binding region [chemical binding]; other site 511437004208 ATP-binding site [chemical binding]; other site 511437004209 Ultra-violet resistance protein B; Region: UvrB; pfam12344 511437004210 UvrB/uvrC motif; Region: UVR; pfam02151 511437004211 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511437004212 Zn2+ binding site [ion binding]; other site 511437004213 Mg2+ binding site [ion binding]; other site 511437004214 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 511437004215 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 511437004216 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511437004217 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 511437004218 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 511437004219 active site 511437004220 tetramer interface; other site 511437004221 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 511437004222 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 511437004223 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 511437004224 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 511437004225 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 511437004226 HPr kinase/phosphorylase; Provisional; Region: PRK05428 511437004227 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 511437004228 Hpr binding site; other site 511437004229 active site 511437004230 homohexamer subunit interaction site [polypeptide binding]; other site 511437004231 Predicted membrane protein [Function unknown]; Region: COG1950 511437004232 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 511437004233 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 511437004234 PhoU domain; Region: PhoU; pfam01895 511437004235 PhoU domain; Region: PhoU; pfam01895 511437004236 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 511437004237 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 511437004238 Walker A/P-loop; other site 511437004239 ATP binding site [chemical binding]; other site 511437004240 Q-loop/lid; other site 511437004241 ABC transporter signature motif; other site 511437004242 Walker B; other site 511437004243 D-loop; other site 511437004244 H-loop/switch region; other site 511437004245 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 511437004246 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 511437004247 Walker A/P-loop; other site 511437004248 ATP binding site [chemical binding]; other site 511437004249 Q-loop/lid; other site 511437004250 ABC transporter signature motif; other site 511437004251 Walker B; other site 511437004252 D-loop; other site 511437004253 H-loop/switch region; other site 511437004254 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 511437004255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437004256 dimer interface [polypeptide binding]; other site 511437004257 conserved gate region; other site 511437004258 putative PBP binding loops; other site 511437004259 ABC-ATPase subunit interface; other site 511437004260 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 511437004261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437004262 dimer interface [polypeptide binding]; other site 511437004263 conserved gate region; other site 511437004264 putative PBP binding loops; other site 511437004265 ABC-ATPase subunit interface; other site 511437004266 PBP superfamily domain; Region: PBP_like_2; cl17296 511437004267 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 511437004268 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 511437004269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511437004270 dimer interface [polypeptide binding]; other site 511437004271 phosphorylation site [posttranslational modification] 511437004272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437004273 ATP binding site [chemical binding]; other site 511437004274 Mg2+ binding site [ion binding]; other site 511437004275 G-X-G motif; other site 511437004276 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511437004277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511437004278 active site 511437004279 phosphorylation site [posttranslational modification] 511437004280 intermolecular recognition site; other site 511437004281 dimerization interface [polypeptide binding]; other site 511437004282 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511437004283 DNA binding site [nucleotide binding] 511437004284 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 511437004285 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 511437004286 peptide chain release factor 2; Validated; Region: prfB; PRK00578 511437004287 This domain is found in peptide chain release factors; Region: PCRF; smart00937 511437004288 RF-1 domain; Region: RF-1; pfam00472 511437004289 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 511437004290 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 511437004291 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437004292 nucleotide binding region [chemical binding]; other site 511437004293 ATP-binding site [chemical binding]; other site 511437004294 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 511437004295 30S subunit binding site; other site 511437004296 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 511437004297 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437004298 active site 511437004299 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 511437004300 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511437004301 ATP binding site [chemical binding]; other site 511437004302 putative Mg++ binding site [ion binding]; other site 511437004303 helicase superfamily c-terminal domain; Region: HELICc; smart00490 511437004304 ATP-binding site [chemical binding]; other site 511437004305 Uncharacterized conserved protein [Function unknown]; Region: COG1739 511437004306 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 511437004307 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 511437004308 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437004309 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437004310 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 511437004311 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 511437004312 Mg++ binding site [ion binding]; other site 511437004313 putative catalytic motif [active] 511437004314 substrate binding site [chemical binding]; other site 511437004315 LrgA family; Region: LrgA; pfam03788 511437004316 LrgB-like family; Region: LrgB; cl00596 511437004317 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 511437004318 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 511437004319 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 511437004320 ring oligomerisation interface [polypeptide binding]; other site 511437004321 ATP/Mg binding site [chemical binding]; other site 511437004322 stacking interactions; other site 511437004323 hinge regions; other site 511437004324 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 511437004325 oligomerisation interface [polypeptide binding]; other site 511437004326 mobile loop; other site 511437004327 roof hairpin; other site 511437004328 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 511437004329 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 511437004330 CoA binding domain; Region: CoA_binding; pfam02629 511437004331 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 511437004332 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511437004333 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511437004334 ABC transporter; Region: ABC_tran_2; pfam12848 511437004335 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511437004336 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511437004337 Helix-turn-helix domain; Region: HTH_28; pfam13518 511437004338 Helix-turn-helix domain; Region: HTH_28; pfam13518 511437004339 putative transposase OrfB; Reviewed; Region: PHA02517 511437004340 HTH-like domain; Region: HTH_21; pfam13276 511437004341 Integrase core domain; Region: rve; pfam00665 511437004342 Integrase core domain; Region: rve_3; pfam13683 511437004343 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437004344 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437004345 UGMP family protein; Validated; Region: PRK09604 511437004346 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 511437004347 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 511437004348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437004349 Coenzyme A binding pocket [chemical binding]; other site 511437004350 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 511437004351 Glycoprotease family; Region: Peptidase_M22; pfam00814 511437004352 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 511437004353 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 511437004354 active site 511437004355 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 511437004356 active site 511437004357 Predicted methyltransferases [General function prediction only]; Region: COG0313 511437004358 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 511437004359 putative SAM binding site [chemical binding]; other site 511437004360 putative homodimer interface [polypeptide binding]; other site 511437004361 Protein of unknown function (DUF972); Region: DUF972; pfam06156 511437004362 DNA polymerase III subunit delta'; Validated; Region: PRK08058 511437004363 DNA polymerase III subunit delta'; Validated; Region: PRK08485 511437004364 Protein of unknown function (DUF970); Region: DUF970; cl17525 511437004365 thymidylate kinase; Validated; Region: tmk; PRK00698 511437004366 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 511437004367 TMP-binding site; other site 511437004368 ATP-binding site [chemical binding]; other site 511437004369 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 511437004370 recombination protein RecR; Reviewed; Region: recR; PRK00076 511437004371 RecR protein; Region: RecR; pfam02132 511437004372 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 511437004373 putative active site [active] 511437004374 putative metal-binding site [ion binding]; other site 511437004375 tetramer interface [polypeptide binding]; other site 511437004376 hypothetical protein; Validated; Region: PRK00153 511437004377 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 511437004378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437004379 Walker A motif; other site 511437004380 ATP binding site [chemical binding]; other site 511437004381 Walker B motif; other site 511437004382 arginine finger; other site 511437004383 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 511437004384 nucleoside/Zn binding site; other site 511437004385 dimer interface [polypeptide binding]; other site 511437004386 catalytic motif [active] 511437004387 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 511437004388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437004389 S-adenosylmethionine binding site [chemical binding]; other site 511437004390 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 511437004391 catalytic residues [active] 511437004392 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 511437004393 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 511437004394 Class I ribonucleotide reductase; Region: RNR_I; cd01679 511437004395 active site 511437004396 dimer interface [polypeptide binding]; other site 511437004397 catalytic residues [active] 511437004398 effector binding site; other site 511437004399 R2 peptide binding site; other site 511437004400 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 511437004401 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 511437004402 dimer interface [polypeptide binding]; other site 511437004403 putative radical transfer pathway; other site 511437004404 diiron center [ion binding]; other site 511437004405 tyrosyl radical; other site 511437004406 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 511437004407 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 511437004408 homodimer interface [polypeptide binding]; other site 511437004409 ligand binding site [chemical binding]; other site 511437004410 NAD binding site [chemical binding]; other site 511437004411 catalytic site [active] 511437004412 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 511437004413 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 511437004414 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 511437004415 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 511437004416 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 511437004417 NAD binding site [chemical binding]; other site 511437004418 homodimer interface [polypeptide binding]; other site 511437004419 active site 511437004420 substrate binding site [chemical binding]; other site 511437004421 galactokinase; Provisional; Region: PRK05322 511437004422 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 511437004423 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511437004424 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 511437004425 Predicted integral membrane protein [Function unknown]; Region: COG0392 511437004426 Uncharacterized conserved protein [Function unknown]; Region: COG2898 511437004427 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 511437004428 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437004429 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437004430 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 511437004431 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 511437004432 active site 511437004433 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 511437004434 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 511437004435 Peptidase family M23; Region: Peptidase_M23; pfam01551 511437004436 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 511437004437 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 511437004438 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 511437004439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 511437004440 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 511437004441 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 511437004442 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 511437004443 Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369 511437004444 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 511437004445 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 511437004446 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 511437004447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 511437004448 Terminase-like family; Region: Terminase_6; pfam03237 511437004449 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 511437004450 Homeodomain-like domain; Region: HTH_23; pfam13384 511437004451 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 511437004452 YopX protein; Region: YopX; pfam09643 511437004453 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 511437004454 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 511437004455 AntA/AntB antirepressor; Region: AntA; cl01430 511437004456 ORF6C domain; Region: ORF6C; pfam10552 511437004457 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 511437004458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437004459 Walker A motif; other site 511437004460 ATP binding site [chemical binding]; other site 511437004461 Walker B motif; other site 511437004462 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 511437004463 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 511437004464 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 511437004465 RecT family; Region: RecT; pfam03837 511437004466 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511437004467 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437004468 non-specific DNA binding site [nucleotide binding]; other site 511437004469 salt bridge; other site 511437004470 sequence-specific DNA binding site [nucleotide binding]; other site 511437004471 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437004472 non-specific DNA binding site [nucleotide binding]; other site 511437004473 salt bridge; other site 511437004474 sequence-specific DNA binding site [nucleotide binding]; other site 511437004475 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511437004476 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437004477 non-specific DNA binding site [nucleotide binding]; other site 511437004478 salt bridge; other site 511437004479 sequence-specific DNA binding site [nucleotide binding]; other site 511437004480 Domain of unknown function (DUF955); Region: DUF955; pfam06114 511437004481 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 511437004482 active site 511437004483 DNA binding site [nucleotide binding] 511437004484 Int/Topo IB signature motif; other site 511437004485 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 511437004486 peripheral dimer interface [polypeptide binding]; other site 511437004487 core dimer interface [polypeptide binding]; other site 511437004488 L10 interface [polypeptide binding]; other site 511437004489 L11 interface [polypeptide binding]; other site 511437004490 putative EF-Tu interaction site [polypeptide binding]; other site 511437004491 putative EF-G interaction site [polypeptide binding]; other site 511437004492 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 511437004493 23S rRNA interface [nucleotide binding]; other site 511437004494 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 511437004495 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 511437004496 mRNA/rRNA interface [nucleotide binding]; other site 511437004497 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 511437004498 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 511437004499 23S rRNA interface [nucleotide binding]; other site 511437004500 L7/L12 interface [polypeptide binding]; other site 511437004501 putative thiostrepton binding site; other site 511437004502 L25 interface [polypeptide binding]; other site 511437004503 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 511437004504 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 511437004505 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 511437004506 putative homodimer interface [polypeptide binding]; other site 511437004507 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 511437004508 heterodimer interface [polypeptide binding]; other site 511437004509 homodimer interface [polypeptide binding]; other site 511437004510 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 511437004511 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 511437004512 RNA polymerase factor sigma-70; Validated; Region: PRK08295 511437004513 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511437004514 YacP-like NYN domain; Region: NYN_YacP; pfam05991 511437004515 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 511437004516 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 511437004517 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 511437004518 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 511437004519 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 511437004520 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 511437004521 active site 511437004522 HIGH motif; other site 511437004523 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 511437004524 KMSKS motif; other site 511437004525 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 511437004526 tRNA binding surface [nucleotide binding]; other site 511437004527 anticodon binding site; other site 511437004528 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437004529 Helix-turn-helix domain; Region: HTH_38; pfam13936 511437004530 Integrase core domain; Region: rve; pfam00665 511437004531 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 511437004532 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511437004533 active site 511437004534 HIGH motif; other site 511437004535 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511437004536 active site 511437004537 KMSKS motif; other site 511437004538 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 511437004539 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 511437004540 putative active site [active] 511437004541 DNA repair protein RadA; Provisional; Region: PRK11823 511437004542 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 511437004543 Walker A motif/ATP binding site; other site 511437004544 ATP binding site [chemical binding]; other site 511437004545 Walker B motif; other site 511437004546 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 511437004547 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 511437004548 trimer interface [polypeptide binding]; other site 511437004549 active site 511437004550 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 511437004551 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511437004552 active site 511437004553 dimer interface [polypeptide binding]; other site 511437004554 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 511437004555 trimer interface [polypeptide binding]; other site 511437004556 active site 511437004557 G bulge; other site 511437004558 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437004559 catalytic core [active] 511437004560 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437004561 Predicted permeases [General function prediction only]; Region: COG0679 511437004562 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 511437004563 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 511437004564 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 511437004565 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 511437004566 active site 511437004567 phosphorylation site [posttranslational modification] 511437004568 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 511437004569 active pocket/dimerization site; other site 511437004570 active site 511437004571 phosphorylation site [posttranslational modification] 511437004572 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 511437004573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437004574 active site 511437004575 motif I; other site 511437004576 motif II; other site 511437004577 homoserine kinase; Provisional; Region: PRK01212 511437004578 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511437004579 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 511437004580 hypothetical protein; Provisional; Region: PRK04351 511437004581 SprT homologues; Region: SprT; cl01182 511437004582 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 511437004583 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 511437004584 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 511437004585 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 511437004586 RNA binding site [nucleotide binding]; other site 511437004587 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 511437004588 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 511437004589 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437004590 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 511437004591 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437004592 motif II; other site 511437004593 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 511437004594 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 511437004595 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 511437004596 homodimer interface [polypeptide binding]; other site 511437004597 NAD binding pocket [chemical binding]; other site 511437004598 ATP binding pocket [chemical binding]; other site 511437004599 Mg binding site [ion binding]; other site 511437004600 active-site loop [active] 511437004601 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 511437004602 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 511437004603 active site 511437004604 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 511437004605 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 511437004606 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 511437004607 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511437004608 DNA-binding site [nucleotide binding]; DNA binding site 511437004609 UTRA domain; Region: UTRA; pfam07702 511437004610 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 511437004611 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 511437004612 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 511437004613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437004614 putative substrate translocation pore; other site 511437004615 POT family; Region: PTR2; cl17359 511437004616 methionine cluster; other site 511437004617 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 511437004618 active site 511437004619 phosphorylation site [posttranslational modification] 511437004620 metal binding site [ion binding]; metal-binding site 511437004621 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 511437004622 active site 511437004623 P-loop; other site 511437004624 phosphorylation site [posttranslational modification] 511437004625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437004626 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437004627 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 511437004628 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 511437004629 active site 511437004630 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 511437004631 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 511437004632 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 511437004633 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 511437004634 NlpC/P60 family; Region: NLPC_P60; cl17555 511437004635 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 511437004636 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 511437004637 Phage major tail protein; Region: Phage_tail; pfam04630 511437004638 Protein of unknown function (DUF806); Region: DUF806; pfam05657 511437004639 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 511437004640 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 511437004641 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 511437004642 Phage capsid family; Region: Phage_capsid; pfam05065 511437004643 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 511437004644 oligomer interface [polypeptide binding]; other site 511437004645 active site residues [active] 511437004646 Phage-related protein [Function unknown]; Region: COG4695; cl01923 511437004647 Phage portal protein; Region: Phage_portal; pfam04860 511437004648 Phage Terminase; Region: Terminase_1; pfam03354 511437004649 Phage terminase, small subunit; Region: Terminase_4; pfam05119 511437004650 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 511437004651 active site 511437004652 YopX protein; Region: YopX; pfam09643 511437004653 VRR-NUC domain; Region: VRR_NUC; pfam08774 511437004654 Uncharacterized conserved protein [Function unknown]; Region: COG4983 511437004655 D5 N terminal like; Region: D5_N; pfam08706 511437004656 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 511437004657 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 511437004658 Protein of unknown function (DUF669); Region: DUF669; pfam05037 511437004659 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 511437004660 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511437004661 ATP binding site [chemical binding]; other site 511437004662 putative Mg++ binding site [ion binding]; other site 511437004663 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437004664 nucleotide binding region [chemical binding]; other site 511437004665 ATP-binding site [chemical binding]; other site 511437004666 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 511437004667 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 511437004668 AAA domain; Region: AAA_24; pfam13479 511437004669 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 511437004670 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 511437004671 Domain of unknown function (DUF771); Region: DUF771; cl09962 511437004672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437004673 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 511437004674 non-specific DNA binding site [nucleotide binding]; other site 511437004675 salt bridge; other site 511437004676 sequence-specific DNA binding site [nucleotide binding]; other site 511437004677 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 511437004678 Catalytic site [active] 511437004679 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 511437004680 Int/Topo IB signature motif; other site 511437004681 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 511437004682 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 511437004683 dimer interface [polypeptide binding]; other site 511437004684 putative anticodon binding site; other site 511437004685 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 511437004686 motif 1; other site 511437004687 active site 511437004688 motif 2; other site 511437004689 motif 3; other site 511437004690 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 511437004691 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 511437004692 FMN binding site [chemical binding]; other site 511437004693 active site 511437004694 catalytic residues [active] 511437004695 substrate binding site [chemical binding]; other site 511437004696 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 511437004697 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 511437004698 dimerization interface [polypeptide binding]; other site 511437004699 domain crossover interface; other site 511437004700 redox-dependent activation switch; other site 511437004701 FtsH Extracellular; Region: FtsH_ext; pfam06480 511437004702 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 511437004703 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437004704 Walker A motif; other site 511437004705 ATP binding site [chemical binding]; other site 511437004706 Walker B motif; other site 511437004707 arginine finger; other site 511437004708 Peptidase family M41; Region: Peptidase_M41; pfam01434 511437004709 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 511437004710 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437004711 active site 511437004712 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 511437004713 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 511437004714 Ligand Binding Site [chemical binding]; other site 511437004715 TilS substrate C-terminal domain; Region: TilS_C; smart00977 511437004716 hypothetical protein; Provisional; Region: PRK08582 511437004717 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 511437004718 RNA binding site [nucleotide binding]; other site 511437004719 Septum formation initiator; Region: DivIC; cl17659 511437004720 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511437004721 RNA binding surface [nucleotide binding]; other site 511437004722 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 511437004723 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 511437004724 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 511437004725 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 511437004726 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511437004727 ATP binding site [chemical binding]; other site 511437004728 putative Mg++ binding site [ion binding]; other site 511437004729 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437004730 nucleotide binding region [chemical binding]; other site 511437004731 ATP-binding site [chemical binding]; other site 511437004732 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 511437004733 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 511437004734 putative active site [active] 511437004735 catalytic residue [active] 511437004736 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 511437004737 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 511437004738 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511437004739 NAD binding site [chemical binding]; other site 511437004740 dimer interface [polypeptide binding]; other site 511437004741 substrate binding site [chemical binding]; other site 511437004742 FOG: CBS domain [General function prediction only]; Region: COG0517 511437004743 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 511437004744 PemK-like protein; Region: PemK; pfam02452 511437004745 alanine racemase; Reviewed; Region: alr; PRK00053 511437004746 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 511437004747 active site 511437004748 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511437004749 dimer interface [polypeptide binding]; other site 511437004750 substrate binding site [chemical binding]; other site 511437004751 catalytic residues [active] 511437004752 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 511437004753 helicase 45; Provisional; Region: PTZ00424 511437004754 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 511437004755 ATP binding site [chemical binding]; other site 511437004756 Mg++ binding site [ion binding]; other site 511437004757 motif III; other site 511437004758 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437004759 nucleotide binding region [chemical binding]; other site 511437004760 ATP-binding site [chemical binding]; other site 511437004761 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 511437004762 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511437004763 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511437004764 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511437004765 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 511437004766 Low molecular weight phosphatase family; Region: LMWPc; cd00115 511437004767 active site 511437004768 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 511437004769 active site 511437004770 catalytic site [active] 511437004771 drug efflux system protein MdtG; Provisional; Region: PRK09874 511437004772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437004773 putative substrate translocation pore; other site 511437004774 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 511437004775 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 511437004776 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 511437004777 hinge; other site 511437004778 active site 511437004779 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 511437004780 Protein export membrane protein; Region: SecD_SecF; cl14618 511437004781 CTP synthetase; Validated; Region: pyrG; PRK05380 511437004782 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 511437004783 Catalytic site [active] 511437004784 active site 511437004785 UTP binding site [chemical binding]; other site 511437004786 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 511437004787 active site 511437004788 putative oxyanion hole; other site 511437004789 catalytic triad [active] 511437004790 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 511437004791 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 511437004792 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 511437004793 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 511437004794 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511437004795 Zn2+ binding site [ion binding]; other site 511437004796 Mg2+ binding site [ion binding]; other site 511437004797 sugar phosphate phosphatase; Provisional; Region: PRK10513 511437004798 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437004799 active site 511437004800 motif I; other site 511437004801 motif II; other site 511437004802 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 511437004803 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 511437004804 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 511437004805 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 511437004806 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437004807 active site 511437004808 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 511437004809 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 511437004810 Substrate binding site; other site 511437004811 Mg++ binding site; other site 511437004812 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 511437004813 active site 511437004814 substrate binding site [chemical binding]; other site 511437004815 CoA binding site [chemical binding]; other site 511437004816 pur operon repressor; Provisional; Region: PRK09213 511437004817 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 511437004818 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437004819 active site 511437004820 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 511437004821 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 511437004822 ABC-ATPase subunit interface; other site 511437004823 dimer interface [polypeptide binding]; other site 511437004824 putative PBP binding regions; other site 511437004825 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 511437004826 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 511437004827 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 511437004828 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511437004829 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 511437004830 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 511437004831 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 511437004832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437004833 S-adenosylmethionine binding site [chemical binding]; other site 511437004834 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 511437004835 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 511437004836 putative active site [active] 511437004837 putative metal binding site [ion binding]; other site 511437004838 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 511437004839 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 511437004840 active site 511437004841 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 511437004842 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 511437004843 active site 511437004844 HIGH motif; other site 511437004845 KMSKS motif; other site 511437004846 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 511437004847 tRNA binding surface [nucleotide binding]; other site 511437004848 anticodon binding site; other site 511437004849 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 511437004850 putative tRNA-binding site [nucleotide binding]; other site 511437004851 dimer interface [polypeptide binding]; other site 511437004852 Protein of unknown function DUF72; Region: DUF72; pfam01904 511437004853 NAD-dependent deacetylase; Provisional; Region: PRK00481 511437004854 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 511437004855 NAD+ binding site [chemical binding]; other site 511437004856 substrate binding site [chemical binding]; other site 511437004857 putative Zn binding site [ion binding]; other site 511437004858 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 511437004859 homodimer interface [polypeptide binding]; other site 511437004860 catalytic residues [active] 511437004861 NAD binding site [chemical binding]; other site 511437004862 substrate binding pocket [chemical binding]; other site 511437004863 flexible flap; other site 511437004864 exopolyphosphatase; Region: exo_poly_only; TIGR03706 511437004865 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 511437004866 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 511437004867 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 511437004868 active site 511437004869 HIGH motif; other site 511437004870 dimer interface [polypeptide binding]; other site 511437004871 KMSKS motif; other site 511437004872 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 511437004873 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 511437004874 putative ligand binding site [chemical binding]; other site 511437004875 NAD binding site [chemical binding]; other site 511437004876 catalytic site [active] 511437004877 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 511437004878 Part of AAA domain; Region: AAA_19; pfam13245 511437004879 Family description; Region: UvrD_C_2; pfam13538 511437004880 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 511437004881 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 511437004882 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511437004883 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 511437004884 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 511437004885 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 511437004886 substrate binding pocket [chemical binding]; other site 511437004887 chain length determination region; other site 511437004888 substrate-Mg2+ binding site; other site 511437004889 catalytic residues [active] 511437004890 aspartate-rich region 1; other site 511437004891 active site lid residues [active] 511437004892 aspartate-rich region 2; other site 511437004893 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 511437004894 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511437004895 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 511437004896 Walker A/P-loop; other site 511437004897 ATP binding site [chemical binding]; other site 511437004898 Q-loop/lid; other site 511437004899 ABC transporter signature motif; other site 511437004900 Walker B; other site 511437004901 D-loop; other site 511437004902 H-loop/switch region; other site 511437004903 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 511437004904 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511437004905 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437004906 Walker A/P-loop; other site 511437004907 ATP binding site [chemical binding]; other site 511437004908 Q-loop/lid; other site 511437004909 ABC transporter signature motif; other site 511437004910 Walker B; other site 511437004911 D-loop; other site 511437004912 H-loop/switch region; other site 511437004913 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 511437004914 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 511437004915 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 511437004916 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 511437004917 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 511437004918 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 511437004919 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 511437004920 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 511437004921 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 511437004922 Walker A/P-loop; other site 511437004923 ATP binding site [chemical binding]; other site 511437004924 Q-loop/lid; other site 511437004925 ABC transporter signature motif; other site 511437004926 Walker B; other site 511437004927 D-loop; other site 511437004928 H-loop/switch region; other site 511437004929 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 511437004930 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 511437004931 ABC-ATPase subunit interface; other site 511437004932 dimer interface [polypeptide binding]; other site 511437004933 putative PBP binding regions; other site 511437004934 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 511437004935 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 511437004936 intersubunit interface [polypeptide binding]; other site 511437004937 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 511437004938 heme-binding site [chemical binding]; other site 511437004939 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 511437004940 heme-binding site [chemical binding]; other site 511437004941 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 511437004942 heme-binding site [chemical binding]; other site 511437004943 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 511437004944 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 511437004945 Sulfatase; Region: Sulfatase; pfam00884 511437004946 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 511437004947 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 511437004948 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511437004949 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511437004950 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 511437004951 putative ADP-binding pocket [chemical binding]; other site 511437004952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437004953 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437004954 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 511437004955 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 511437004956 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 511437004957 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 511437004958 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 511437004959 dimerization domain swap beta strand [polypeptide binding]; other site 511437004960 regulatory protein interface [polypeptide binding]; other site 511437004961 active site 511437004962 regulatory phosphorylation site [posttranslational modification]; other site 511437004963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437004964 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 511437004965 Walker A motif; other site 511437004966 ATP binding site [chemical binding]; other site 511437004967 Walker B motif; other site 511437004968 arginine finger; other site 511437004969 UvrB/uvrC motif; Region: UVR; pfam02151 511437004970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437004971 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 511437004972 Walker A motif; other site 511437004973 ATP binding site [chemical binding]; other site 511437004974 Walker B motif; other site 511437004975 arginine finger; other site 511437004976 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 511437004977 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437004978 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437004979 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511437004980 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437004981 non-specific DNA binding site [nucleotide binding]; other site 511437004982 salt bridge; other site 511437004983 sequence-specific DNA binding site [nucleotide binding]; other site 511437004984 Peptidase family C69; Region: Peptidase_C69; pfam03577 511437004985 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 511437004986 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 511437004987 G1 box; other site 511437004988 putative GEF interaction site [polypeptide binding]; other site 511437004989 GTP/Mg2+ binding site [chemical binding]; other site 511437004990 Switch I region; other site 511437004991 G2 box; other site 511437004992 G3 box; other site 511437004993 Switch II region; other site 511437004994 G4 box; other site 511437004995 G5 box; other site 511437004996 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 511437004997 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 511437004998 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 511437004999 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 511437005000 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 511437005001 active site 511437005002 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 511437005003 Domain of unknown function DUF20; Region: UPF0118; pfam01594 511437005004 hypothetical protein; Provisional; Region: PRK13662 511437005005 RecX family; Region: RecX; cl00936 511437005006 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 511437005007 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 511437005008 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 511437005009 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 511437005010 active site 511437005011 homodimer interface [polypeptide binding]; other site 511437005012 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 511437005013 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 511437005014 Ligand binding site; other site 511437005015 Putative Catalytic site; other site 511437005016 DXD motif; other site 511437005017 Photosystem II protein; Region: PSII; cl08223 511437005018 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 511437005019 Predicted membrane protein [Function unknown]; Region: COG2246 511437005020 GtrA-like protein; Region: GtrA; pfam04138 511437005021 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511437005022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437005023 dimer interface [polypeptide binding]; other site 511437005024 conserved gate region; other site 511437005025 putative PBP binding loops; other site 511437005026 ABC-ATPase subunit interface; other site 511437005027 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511437005028 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511437005029 substrate binding pocket [chemical binding]; other site 511437005030 membrane-bound complex binding site; other site 511437005031 hinge residues; other site 511437005032 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 511437005033 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 511437005034 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 511437005035 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 511437005036 ATP binding site [chemical binding]; other site 511437005037 putative Mg++ binding site [ion binding]; other site 511437005038 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437005039 nucleotide binding region [chemical binding]; other site 511437005040 ATP-binding site [chemical binding]; other site 511437005041 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 511437005042 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 511437005043 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 511437005044 active site 511437005045 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 511437005046 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 511437005047 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 511437005048 putative active site [active] 511437005049 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 511437005050 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 511437005051 N- and C-terminal domain interface [polypeptide binding]; other site 511437005052 active site 511437005053 catalytic site [active] 511437005054 metal binding site [ion binding]; metal-binding site 511437005055 carbohydrate binding site [chemical binding]; other site 511437005056 ATP binding site [chemical binding]; other site 511437005057 GntP family permease; Region: GntP_permease; pfam02447 511437005058 fructuronate transporter; Provisional; Region: PRK10034; cl15264 511437005059 BioY family; Region: BioY; pfam02632 511437005060 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 511437005061 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511437005062 putative DNA binding site [nucleotide binding]; other site 511437005063 putative Zn2+ binding site [ion binding]; other site 511437005064 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 511437005065 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 511437005066 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 511437005067 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 511437005068 NAD binding site [chemical binding]; other site 511437005069 homotetramer interface [polypeptide binding]; other site 511437005070 homodimer interface [polypeptide binding]; other site 511437005071 substrate binding site [chemical binding]; other site 511437005072 active site 511437005073 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 511437005074 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 511437005075 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 511437005076 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 511437005077 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 511437005078 ATP-grasp domain; Region: ATP-grasp_4; cl17255 511437005079 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 511437005080 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 511437005081 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 511437005082 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 511437005083 carboxyltransferase (CT) interaction site; other site 511437005084 biotinylation site [posttranslational modification]; other site 511437005085 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 511437005086 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 511437005087 dimer interface [polypeptide binding]; other site 511437005088 active site 511437005089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437005090 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 511437005091 NAD(P) binding site [chemical binding]; other site 511437005092 active site 511437005093 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 511437005094 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 511437005095 acyl carrier protein; Provisional; Region: acpP; PRK00982 511437005096 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 511437005097 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 511437005098 dimer interface [polypeptide binding]; other site 511437005099 active site 511437005100 CoA binding pocket [chemical binding]; other site 511437005101 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511437005102 MarR family; Region: MarR_2; pfam12802 511437005103 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 511437005104 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 511437005105 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 511437005106 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 511437005107 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 511437005108 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 511437005109 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511437005110 DNA binding residues [nucleotide binding] 511437005111 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 511437005112 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 511437005113 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 511437005114 phosphopentomutase; Provisional; Region: PRK05362 511437005115 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 511437005116 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 511437005117 intersubunit interface [polypeptide binding]; other site 511437005118 active site 511437005119 catalytic residue [active] 511437005120 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 511437005121 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 511437005122 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 511437005123 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 511437005124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437005125 dimer interface [polypeptide binding]; other site 511437005126 conserved gate region; other site 511437005127 putative PBP binding loops; other site 511437005128 ABC-ATPase subunit interface; other site 511437005129 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 511437005130 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 511437005131 Walker A/P-loop; other site 511437005132 ATP binding site [chemical binding]; other site 511437005133 Q-loop/lid; other site 511437005134 ABC transporter signature motif; other site 511437005135 Walker B; other site 511437005136 D-loop; other site 511437005137 H-loop/switch region; other site 511437005138 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 511437005139 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 511437005140 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 511437005141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437005142 S-adenosylmethionine binding site [chemical binding]; other site 511437005143 putative lipid kinase; Reviewed; Region: PRK13055 511437005144 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 511437005145 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 511437005146 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 511437005147 GatB domain; Region: GatB_Yqey; smart00845 511437005148 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 511437005149 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 511437005150 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 511437005151 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 511437005152 putative dimer interface [polypeptide binding]; other site 511437005153 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 511437005154 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 511437005155 putative dimer interface [polypeptide binding]; other site 511437005156 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 511437005157 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 511437005158 nucleotide binding pocket [chemical binding]; other site 511437005159 K-X-D-G motif; other site 511437005160 catalytic site [active] 511437005161 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 511437005162 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 511437005163 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 511437005164 Dimer interface [polypeptide binding]; other site 511437005165 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 511437005166 Part of AAA domain; Region: AAA_19; pfam13245 511437005167 Family description; Region: UvrD_C_2; pfam13538 511437005168 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 511437005169 ATP-grasp domain; Region: ATP-grasp_4; cl17255 511437005170 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437005171 active site 511437005172 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 511437005173 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 511437005174 Predicted membrane protein [Function unknown]; Region: COG4684 511437005175 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 511437005176 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 511437005177 23S rRNA interface [nucleotide binding]; other site 511437005178 L3 interface [polypeptide binding]; other site 511437005179 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 511437005180 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 511437005181 dimerization interface 3.5A [polypeptide binding]; other site 511437005182 active site 511437005183 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 511437005184 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 511437005185 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 511437005186 Walker A/P-loop; other site 511437005187 ATP binding site [chemical binding]; other site 511437005188 Q-loop/lid; other site 511437005189 ABC transporter signature motif; other site 511437005190 Walker B; other site 511437005191 D-loop; other site 511437005192 H-loop/switch region; other site 511437005193 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 511437005194 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 511437005195 Walker A/P-loop; other site 511437005196 ATP binding site [chemical binding]; other site 511437005197 Q-loop/lid; other site 511437005198 ABC transporter signature motif; other site 511437005199 Walker B; other site 511437005200 D-loop; other site 511437005201 H-loop/switch region; other site 511437005202 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 511437005203 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 511437005204 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 511437005205 alphaNTD homodimer interface [polypeptide binding]; other site 511437005206 alphaNTD - beta interaction site [polypeptide binding]; other site 511437005207 alphaNTD - beta' interaction site [polypeptide binding]; other site 511437005208 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 511437005209 30S ribosomal protein S11; Validated; Region: PRK05309 511437005210 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 511437005211 30S ribosomal protein S13; Region: bact_S13; TIGR03631 511437005212 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 511437005213 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 511437005214 rRNA binding site [nucleotide binding]; other site 511437005215 predicted 30S ribosome binding site; other site 511437005216 adenylate kinase; Reviewed; Region: adk; PRK00279 511437005217 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 511437005218 AMP-binding site [chemical binding]; other site 511437005219 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 511437005220 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 511437005221 SecY translocase; Region: SecY; pfam00344 511437005222 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 511437005223 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 511437005224 23S rRNA binding site [nucleotide binding]; other site 511437005225 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 511437005226 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 511437005227 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 511437005228 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 511437005229 23S rRNA interface [nucleotide binding]; other site 511437005230 5S rRNA interface [nucleotide binding]; other site 511437005231 L27 interface [polypeptide binding]; other site 511437005232 L5 interface [polypeptide binding]; other site 511437005233 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 511437005234 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 511437005235 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 511437005236 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 511437005237 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 511437005238 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 511437005239 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 511437005240 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 511437005241 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 511437005242 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 511437005243 RNA binding site [nucleotide binding]; other site 511437005244 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 511437005245 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 511437005246 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 511437005247 23S rRNA interface [nucleotide binding]; other site 511437005248 putative translocon interaction site; other site 511437005249 signal recognition particle (SRP54) interaction site; other site 511437005250 L23 interface [polypeptide binding]; other site 511437005251 trigger factor interaction site; other site 511437005252 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 511437005253 23S rRNA interface [nucleotide binding]; other site 511437005254 5S rRNA interface [nucleotide binding]; other site 511437005255 putative antibiotic binding site [chemical binding]; other site 511437005256 L25 interface [polypeptide binding]; other site 511437005257 L27 interface [polypeptide binding]; other site 511437005258 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 511437005259 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 511437005260 G-X-X-G motif; other site 511437005261 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 511437005262 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 511437005263 putative translocon binding site; other site 511437005264 protein-rRNA interface [nucleotide binding]; other site 511437005265 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 511437005266 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 511437005267 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 511437005268 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 511437005269 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 511437005270 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 511437005271 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 511437005272 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 511437005273 elongation factor G; Reviewed; Region: PRK12739 511437005274 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 511437005275 G1 box; other site 511437005276 putative GEF interaction site [polypeptide binding]; other site 511437005277 GTP/Mg2+ binding site [chemical binding]; other site 511437005278 Switch I region; other site 511437005279 G2 box; other site 511437005280 G3 box; other site 511437005281 Switch II region; other site 511437005282 G4 box; other site 511437005283 G5 box; other site 511437005284 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 511437005285 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 511437005286 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 511437005287 30S ribosomal protein S7; Validated; Region: PRK05302 511437005288 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 511437005289 S17 interaction site [polypeptide binding]; other site 511437005290 S8 interaction site; other site 511437005291 16S rRNA interaction site [nucleotide binding]; other site 511437005292 streptomycin interaction site [chemical binding]; other site 511437005293 23S rRNA interaction site [nucleotide binding]; other site 511437005294 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 511437005295 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 511437005296 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 511437005297 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 511437005298 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 511437005299 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 511437005300 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 511437005301 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 511437005302 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 511437005303 cleft; other site 511437005304 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 511437005305 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 511437005306 DNA binding site [nucleotide binding] 511437005307 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 511437005308 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 511437005309 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 511437005310 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 511437005311 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 511437005312 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 511437005313 RPB1 interaction site [polypeptide binding]; other site 511437005314 RPB10 interaction site [polypeptide binding]; other site 511437005315 RPB11 interaction site [polypeptide binding]; other site 511437005316 RPB3 interaction site [polypeptide binding]; other site 511437005317 RPB12 interaction site [polypeptide binding]; other site 511437005318 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 511437005319 Clp amino terminal domain; Region: Clp_N; pfam02861 511437005320 Clp amino terminal domain; Region: Clp_N; pfam02861 511437005321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437005322 Walker A motif; other site 511437005323 ATP binding site [chemical binding]; other site 511437005324 Walker B motif; other site 511437005325 arginine finger; other site 511437005326 UvrB/uvrC motif; Region: UVR; pfam02151 511437005327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437005328 Walker A motif; other site 511437005329 ATP binding site [chemical binding]; other site 511437005330 Walker B motif; other site 511437005331 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 511437005332 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 511437005333 seryl-tRNA synthetase; Provisional; Region: PRK05431 511437005334 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 511437005335 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 511437005336 dimer interface [polypeptide binding]; other site 511437005337 active site 511437005338 motif 1; other site 511437005339 motif 2; other site 511437005340 motif 3; other site 511437005341 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 511437005342 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 511437005343 Substrate-binding site [chemical binding]; other site 511437005344 Substrate specificity [chemical binding]; other site 511437005345 Class I aldolases; Region: Aldolase_Class_I; cl17187 511437005346 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 511437005347 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 511437005348 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 511437005349 Coenzyme A binding pocket [chemical binding]; other site 511437005350 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 511437005351 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 511437005352 active site 511437005353 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 511437005354 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 511437005355 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 511437005356 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 511437005357 Predicted membrane protein [Function unknown]; Region: COG4709 511437005358 Predicted transcriptional regulators [Transcription]; Region: COG1695 511437005359 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 511437005360 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 511437005361 Uncharacterized conserved protein [Function unknown]; Region: COG2966 511437005362 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 511437005363 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 511437005364 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 511437005365 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 511437005366 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 511437005367 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 511437005368 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 511437005369 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 511437005370 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 511437005371 DNA binding residues [nucleotide binding] 511437005372 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 511437005373 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 511437005374 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 511437005375 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511437005376 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437005377 non-specific DNA binding site [nucleotide binding]; other site 511437005378 salt bridge; other site 511437005379 sequence-specific DNA binding site [nucleotide binding]; other site 511437005380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437005381 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 511437005382 Coenzyme A binding pocket [chemical binding]; other site 511437005383 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 511437005384 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 511437005385 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 511437005386 active site 511437005387 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 511437005388 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 511437005389 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511437005390 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 511437005391 hypothetical protein; Provisional; Region: PRK00967 511437005392 chromosome segregation protein; Provisional; Region: PRK03918 511437005393 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 511437005394 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 511437005395 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 511437005396 inhibitor-cofactor binding pocket; inhibition site 511437005397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437005398 catalytic residue [active] 511437005399 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 511437005400 nucleotide binding site [chemical binding]; other site 511437005401 N-acetyl-L-glutamate binding site [chemical binding]; other site 511437005402 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 511437005403 heterotetramer interface [polypeptide binding]; other site 511437005404 active site pocket [active] 511437005405 cleavage site 511437005406 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 511437005407 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 511437005408 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 511437005409 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 511437005410 homodimer interface [polypeptide binding]; other site 511437005411 substrate-cofactor binding pocket; other site 511437005412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437005413 catalytic residue [active] 511437005414 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 511437005415 proposed active site lysine [active] 511437005416 conserved cys residue [active] 511437005417 Uncharacterized conserved protein [Function unknown]; Region: COG2966 511437005418 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 511437005419 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 511437005420 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 511437005421 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 511437005422 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511437005423 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 511437005424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437005425 NADH(P)-binding; Region: NAD_binding_10; pfam13460 511437005426 NAD(P) binding site [chemical binding]; other site 511437005427 active site 511437005428 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 511437005429 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 511437005430 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 511437005431 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 511437005432 DNA binding residues [nucleotide binding] 511437005433 putative dimer interface [polypeptide binding]; other site 511437005434 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511437005435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511437005436 active site 511437005437 phosphorylation site [posttranslational modification] 511437005438 intermolecular recognition site; other site 511437005439 dimerization interface [polypeptide binding]; other site 511437005440 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511437005441 DNA binding site [nucleotide binding] 511437005442 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 511437005443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511437005444 dimer interface [polypeptide binding]; other site 511437005445 phosphorylation site [posttranslational modification] 511437005446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437005447 ATP binding site [chemical binding]; other site 511437005448 Mg2+ binding site [ion binding]; other site 511437005449 G-X-G motif; other site 511437005450 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 511437005451 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 511437005452 active site 511437005453 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 511437005454 EamA-like transporter family; Region: EamA; pfam00892 511437005455 EamA-like transporter family; Region: EamA; pfam00892 511437005456 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 511437005457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437005458 S-adenosylmethionine binding site [chemical binding]; other site 511437005459 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 511437005460 DNA binding residues [nucleotide binding] 511437005461 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 511437005462 putative dimer interface [polypeptide binding]; other site 511437005463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005464 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437005465 putative substrate translocation pore; other site 511437005466 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 511437005467 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437005468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437005469 homodimer interface [polypeptide binding]; other site 511437005470 catalytic residue [active] 511437005471 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 511437005472 active site 511437005473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005474 H+ Antiporter protein; Region: 2A0121; TIGR00900 511437005475 putative substrate translocation pore; other site 511437005476 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 511437005477 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 511437005478 catalytic Zn binding site [ion binding]; other site 511437005479 NAD(P) binding site [chemical binding]; other site 511437005480 structural Zn binding site [ion binding]; other site 511437005481 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 511437005482 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 511437005483 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 511437005484 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 511437005485 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437005486 Soluble P-type ATPase [General function prediction only]; Region: COG4087 511437005487 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 511437005488 Penicillinase repressor; Region: Pencillinase_R; pfam03965 511437005489 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 511437005490 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437005491 Coenzyme A binding pocket [chemical binding]; other site 511437005492 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 511437005493 active site 511437005494 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 511437005495 Peptidase family M1; Region: Peptidase_M1; pfam01433 511437005496 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 511437005497 Zn binding site [ion binding]; other site 511437005498 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 511437005499 short chain dehydrogenase; Validated; Region: PRK06182 511437005500 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 511437005501 NADP binding site [chemical binding]; other site 511437005502 active site 511437005503 steroid binding site; other site 511437005504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511437005505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511437005506 Predicted membrane protein [Function unknown]; Region: COG2364 511437005507 Sugar transport protein; Region: Sugar_transport; pfam06800 511437005508 Predicted membrane protein [Function unknown]; Region: COG1511 511437005509 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 511437005510 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 511437005511 Predicted membrane protein [Function unknown]; Region: COG1511 511437005512 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 511437005513 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 511437005514 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 511437005515 Uncharacterized conserved protein [Function unknown]; Region: COG1284 511437005516 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 511437005517 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 511437005518 GMP synthase; Reviewed; Region: guaA; PRK00074 511437005519 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 511437005520 AMP/PPi binding site [chemical binding]; other site 511437005521 candidate oxyanion hole; other site 511437005522 catalytic triad [active] 511437005523 potential glutamine specificity residues [chemical binding]; other site 511437005524 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 511437005525 ATP Binding subdomain [chemical binding]; other site 511437005526 Dimerization subdomain; other site 511437005527 pantothenate kinase; Provisional; Region: PRK05439 511437005528 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 511437005529 ATP-binding site [chemical binding]; other site 511437005530 CoA-binding site [chemical binding]; other site 511437005531 Mg2+-binding site [ion binding]; other site 511437005532 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 511437005533 Part of AAA domain; Region: AAA_19; pfam13245 511437005534 Family description; Region: UvrD_C_2; pfam13538 511437005535 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437005536 catalytic core [active] 511437005537 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437005538 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 511437005539 metal binding site [ion binding]; metal-binding site 511437005540 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 511437005541 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 511437005542 DNA binding residues [nucleotide binding] 511437005543 putative dimer interface [polypeptide binding]; other site 511437005544 maltose O-acetyltransferase; Provisional; Region: PRK10092 511437005545 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 511437005546 active site 511437005547 substrate binding site [chemical binding]; other site 511437005548 trimer interface [polypeptide binding]; other site 511437005549 CoA binding site [chemical binding]; other site 511437005550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437005551 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 511437005552 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 511437005553 DNA binding residues [nucleotide binding] 511437005554 putative dimer interface [polypeptide binding]; other site 511437005555 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511437005556 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 511437005557 Walker A/P-loop; other site 511437005558 ATP binding site [chemical binding]; other site 511437005559 Q-loop/lid; other site 511437005560 ABC transporter signature motif; other site 511437005561 Walker B; other site 511437005562 D-loop; other site 511437005563 H-loop/switch region; other site 511437005564 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511437005565 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 511437005566 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511437005567 Walker A/P-loop; other site 511437005568 ATP binding site [chemical binding]; other site 511437005569 Q-loop/lid; other site 511437005570 ABC transporter signature motif; other site 511437005571 Walker B; other site 511437005572 D-loop; other site 511437005573 H-loop/switch region; other site 511437005574 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511437005575 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 511437005576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437005577 dimer interface [polypeptide binding]; other site 511437005578 conserved gate region; other site 511437005579 putative PBP binding loops; other site 511437005580 ABC-ATPase subunit interface; other site 511437005581 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 511437005582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 511437005583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437005584 dimer interface [polypeptide binding]; other site 511437005585 ABC-ATPase subunit interface; other site 511437005586 putative PBP binding loops; other site 511437005587 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511437005588 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511437005589 peptide binding site [polypeptide binding]; other site 511437005590 GTPases [General function prediction only]; Region: HflX; COG2262 511437005591 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 511437005592 HflX GTPase family; Region: HflX; cd01878 511437005593 G1 box; other site 511437005594 GTP/Mg2+ binding site [chemical binding]; other site 511437005595 Switch I region; other site 511437005596 G2 box; other site 511437005597 G3 box; other site 511437005598 Switch II region; other site 511437005599 G4 box; other site 511437005600 G5 box; other site 511437005601 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 511437005602 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 511437005603 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 511437005604 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 511437005605 putative NAD(P) binding site [chemical binding]; other site 511437005606 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511437005607 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437005608 DNA binding site [nucleotide binding] 511437005609 domain linker motif; other site 511437005610 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 511437005611 dimerization interface [polypeptide binding]; other site 511437005612 ligand binding site [chemical binding]; other site 511437005613 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 511437005614 MgtC family; Region: MgtC; pfam02308 511437005615 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511437005616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437005617 dimer interface [polypeptide binding]; other site 511437005618 conserved gate region; other site 511437005619 putative PBP binding loops; other site 511437005620 ABC-ATPase subunit interface; other site 511437005621 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511437005622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437005623 dimer interface [polypeptide binding]; other site 511437005624 conserved gate region; other site 511437005625 putative PBP binding loops; other site 511437005626 ABC-ATPase subunit interface; other site 511437005627 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511437005628 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511437005629 substrate binding pocket [chemical binding]; other site 511437005630 membrane-bound complex binding site; other site 511437005631 hinge residues; other site 511437005632 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511437005633 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 511437005634 Walker A/P-loop; other site 511437005635 ATP binding site [chemical binding]; other site 511437005636 Q-loop/lid; other site 511437005637 ABC transporter signature motif; other site 511437005638 Walker B; other site 511437005639 D-loop; other site 511437005640 H-loop/switch region; other site 511437005641 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 511437005642 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 511437005643 catalytic triad [active] 511437005644 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 511437005645 metal binding site 2 [ion binding]; metal-binding site 511437005646 putative DNA binding helix; other site 511437005647 metal binding site 1 [ion binding]; metal-binding site 511437005648 dimer interface [polypeptide binding]; other site 511437005649 structural Zn2+ binding site [ion binding]; other site 511437005650 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 511437005651 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 511437005652 catalytic site [active] 511437005653 G-X2-G-X-G-K; other site 511437005654 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 511437005655 active site 511437005656 Ap4A binding cleft/pocket [chemical binding]; other site 511437005657 P4 phosphate binding site; other site 511437005658 nudix motif; other site 511437005659 putative P2/P3 phosphate binding site [ion binding]; other site 511437005660 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 511437005661 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 511437005662 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 511437005663 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437005664 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 511437005665 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 511437005666 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 511437005667 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 511437005668 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 511437005669 ligand binding site [chemical binding]; other site 511437005670 homodimer interface [polypeptide binding]; other site 511437005671 NAD(P) binding site [chemical binding]; other site 511437005672 trimer interface B [polypeptide binding]; other site 511437005673 trimer interface A [polypeptide binding]; other site 511437005674 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 511437005675 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 511437005676 beta-D-glucuronidase; Provisional; Region: PRK10150 511437005677 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 511437005678 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 511437005679 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 511437005680 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511437005681 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 511437005682 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511437005683 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 511437005684 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 511437005685 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 511437005686 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 511437005687 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511437005688 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437005689 DNA binding site [nucleotide binding] 511437005690 domain linker motif; other site 511437005691 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 511437005692 dimerization interface [polypeptide binding]; other site 511437005693 ligand binding site [chemical binding]; other site 511437005694 sodium binding site [ion binding]; other site 511437005695 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 511437005696 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 511437005697 Ca binding site [ion binding]; other site 511437005698 active site 511437005699 catalytic site [active] 511437005700 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 511437005701 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 511437005702 active site 511437005703 homodimer interface [polypeptide binding]; other site 511437005704 catalytic site [active] 511437005705 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 511437005706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005707 hypothetical protein; Provisional; Region: PRK10621 511437005708 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 511437005709 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 511437005710 galactonate dehydratase; Provisional; Region: PRK14017 511437005711 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 511437005712 active site pocket [active] 511437005713 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 511437005714 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 511437005715 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 511437005716 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511437005717 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511437005718 peptide binding site [polypeptide binding]; other site 511437005719 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 511437005720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437005721 Walker A/P-loop; other site 511437005722 ATP binding site [chemical binding]; other site 511437005723 Q-loop/lid; other site 511437005724 ABC transporter signature motif; other site 511437005725 Walker B; other site 511437005726 D-loop; other site 511437005727 H-loop/switch region; other site 511437005728 ABC transporter; Region: ABC_tran_2; pfam12848 511437005729 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511437005730 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 511437005731 active site 511437005732 CAAX protease self-immunity; Region: Abi; pfam02517 511437005733 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 511437005734 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 511437005735 Uncharacterized conserved protein [Function unknown]; Region: COG3410 511437005736 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 511437005737 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 511437005738 active site 511437005739 galactoside permease; Reviewed; Region: lacY; PRK09528 511437005740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005741 putative substrate translocation pore; other site 511437005742 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 511437005743 active site 511437005744 Predicted transcriptional regulator [Transcription]; Region: COG4189 511437005745 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511437005746 putative DNA binding site [nucleotide binding]; other site 511437005747 dimerization interface [polypeptide binding]; other site 511437005748 putative Zn2+ binding site [ion binding]; other site 511437005749 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 511437005750 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 511437005751 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 511437005752 active site 511437005753 catalytic triad [active] 511437005754 oxyanion hole [active] 511437005755 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd12218 511437005756 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 511437005757 tetramer interface [polypeptide binding]; other site 511437005758 putative DNA binding site [nucleotide binding]; other site 511437005759 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 511437005760 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 511437005761 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 511437005762 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 511437005763 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 511437005764 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 511437005765 DNA binding residues [nucleotide binding] 511437005766 putative dimer interface [polypeptide binding]; other site 511437005767 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 511437005768 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 511437005769 NADP binding site [chemical binding]; other site 511437005770 putative substrate binding site [chemical binding]; other site 511437005771 active site 511437005772 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 511437005773 zinc binding site [ion binding]; other site 511437005774 putative ligand binding site [chemical binding]; other site 511437005775 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 511437005776 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 511437005777 TM-ABC transporter signature motif; other site 511437005778 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 511437005779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437005780 Walker A/P-loop; other site 511437005781 ATP binding site [chemical binding]; other site 511437005782 Q-loop/lid; other site 511437005783 ABC transporter signature motif; other site 511437005784 Walker B; other site 511437005785 D-loop; other site 511437005786 H-loop/switch region; other site 511437005787 Predicted membrane protein [Function unknown]; Region: COG1288 511437005788 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 511437005789 hypothetical protein; Provisional; Region: PRK07205 511437005790 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 511437005791 active site 511437005792 metal binding site [ion binding]; metal-binding site 511437005793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005794 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 511437005795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005796 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511437005797 MarR family; Region: MarR; pfam01047 511437005798 pyruvate phosphate dikinase; Provisional; Region: PRK09279 511437005799 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 511437005800 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 511437005801 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 511437005802 HTH domain; Region: HTH_11; pfam08279 511437005803 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 511437005804 FOG: CBS domain [General function prediction only]; Region: COG0517 511437005805 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 511437005806 Acyltransferase family; Region: Acyl_transf_3; pfam01757 511437005807 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 511437005808 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437005809 Coenzyme A binding pocket [chemical binding]; other site 511437005810 uracil transporter; Provisional; Region: PRK10720 511437005811 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437005812 Coenzyme A binding pocket [chemical binding]; other site 511437005813 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 511437005814 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 511437005815 substrate binding site [chemical binding]; other site 511437005816 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511437005817 Ligand Binding Site [chemical binding]; other site 511437005818 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 511437005819 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 511437005820 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511437005821 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 511437005822 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 511437005823 active site residue [active] 511437005824 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 511437005825 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 511437005826 hypothetical protein; Provisional; Region: PRK10621 511437005827 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 511437005828 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 511437005829 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 511437005830 Walker A/P-loop; other site 511437005831 ATP binding site [chemical binding]; other site 511437005832 Q-loop/lid; other site 511437005833 ABC transporter signature motif; other site 511437005834 Walker B; other site 511437005835 D-loop; other site 511437005836 H-loop/switch region; other site 511437005837 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 511437005838 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 511437005839 Walker A/P-loop; other site 511437005840 ATP binding site [chemical binding]; other site 511437005841 Q-loop/lid; other site 511437005842 ABC transporter signature motif; other site 511437005843 Walker B; other site 511437005844 D-loop; other site 511437005845 H-loop/switch region; other site 511437005846 Cobalt transport protein; Region: CbiQ; cl00463 511437005847 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 511437005848 NlpC/P60 family; Region: NLPC_P60; pfam00877 511437005849 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 511437005850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005851 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437005852 putative substrate translocation pore; other site 511437005853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005854 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 511437005855 Cadmium resistance transporter; Region: Cad; pfam03596 511437005856 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 511437005857 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511437005858 ATP binding site [chemical binding]; other site 511437005859 putative Mg++ binding site [ion binding]; other site 511437005860 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437005861 nucleotide binding region [chemical binding]; other site 511437005862 ATP-binding site [chemical binding]; other site 511437005863 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 511437005864 HRDC domain; Region: HRDC; pfam00570 511437005865 Domain of unknown function (DUF389); Region: DUF389; pfam04087 511437005866 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 511437005867 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 511437005868 catalytic Zn binding site [ion binding]; other site 511437005869 NAD binding site [chemical binding]; other site 511437005870 structural Zn binding site [ion binding]; other site 511437005871 flavodoxin; Provisional; Region: PRK06242 511437005872 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 511437005873 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 511437005874 PYR/PP interface [polypeptide binding]; other site 511437005875 dimer interface [polypeptide binding]; other site 511437005876 tetramer interface [polypeptide binding]; other site 511437005877 TPP binding site [chemical binding]; other site 511437005878 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 511437005879 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 511437005880 TPP-binding site [chemical binding]; other site 511437005881 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 511437005882 active site 511437005883 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 511437005884 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 511437005885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437005886 dimer interface [polypeptide binding]; other site 511437005887 conserved gate region; other site 511437005888 putative PBP binding loops; other site 511437005889 ABC-ATPase subunit interface; other site 511437005890 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 511437005891 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 511437005892 Walker A/P-loop; other site 511437005893 ATP binding site [chemical binding]; other site 511437005894 Q-loop/lid; other site 511437005895 ABC transporter signature motif; other site 511437005896 Walker B; other site 511437005897 D-loop; other site 511437005898 H-loop/switch region; other site 511437005899 NIL domain; Region: NIL; pfam09383 511437005900 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 511437005901 substrate binding site [chemical binding]; other site 511437005902 THF binding site; other site 511437005903 zinc-binding site [ion binding]; other site 511437005904 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 511437005905 putative active site [active] 511437005906 Amidohydrolase; Region: Amidohydro_5; pfam13594 511437005907 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511437005908 guanine deaminase; Region: guan_deamin; TIGR02967 511437005909 active site 511437005910 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 511437005911 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 511437005912 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 511437005913 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 511437005914 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 511437005915 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 511437005916 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 511437005917 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 511437005918 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 511437005919 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 511437005920 metal binding site [ion binding]; metal-binding site 511437005921 dimer interface [polypeptide binding]; other site 511437005922 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 511437005923 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 511437005924 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 511437005925 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 511437005926 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 511437005927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005928 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437005929 putative substrate translocation pore; other site 511437005930 Protein of unknown function, DUF606; Region: DUF606; pfam04657 511437005931 Protein of unknown function, DUF606; Region: DUF606; pfam04657 511437005932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437005933 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 511437005934 NAD(P) binding site [chemical binding]; other site 511437005935 active site 511437005936 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 511437005937 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437005938 catalytic core [active] 511437005939 L-arabinose isomerase; Provisional; Region: PRK02929 511437005940 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 511437005941 hexamer (dimer of trimers) interface [polypeptide binding]; other site 511437005942 trimer interface [polypeptide binding]; other site 511437005943 substrate binding site [chemical binding]; other site 511437005944 Mn binding site [ion binding]; other site 511437005945 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 511437005946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511437005947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511437005948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005949 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437005950 putative substrate translocation pore; other site 511437005951 AAA domain; Region: AAA_14; pfam13173 511437005952 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 511437005953 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 511437005954 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 511437005955 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 511437005956 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437005957 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437005958 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437005959 Uncharacterized conserved protein [Function unknown]; Region: COG0062 511437005960 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 511437005961 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 511437005962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 511437005963 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 511437005964 alpha-galactosidase; Region: PLN02808; cl17638 511437005965 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 511437005966 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 511437005967 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 511437005968 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 511437005969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005970 MFS/sugar transport protein; Region: MFS_2; pfam13347 511437005971 putative substrate translocation pore; other site 511437005972 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 511437005973 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 511437005974 Predicted transcriptional regulator [Transcription]; Region: COG4189 511437005975 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511437005976 dimerization interface [polypeptide binding]; other site 511437005977 putative DNA binding site [nucleotide binding]; other site 511437005978 putative Zn2+ binding site [ion binding]; other site 511437005979 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 511437005980 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 511437005981 active site 511437005982 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 511437005983 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 511437005984 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 511437005985 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 511437005986 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 511437005987 Walker A/P-loop; other site 511437005988 ATP binding site [chemical binding]; other site 511437005989 Q-loop/lid; other site 511437005990 ABC transporter signature motif; other site 511437005991 Walker B; other site 511437005992 D-loop; other site 511437005993 H-loop/switch region; other site 511437005994 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 511437005995 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 511437005996 Walker A/P-loop; other site 511437005997 ATP binding site [chemical binding]; other site 511437005998 Q-loop/lid; other site 511437005999 ABC transporter signature motif; other site 511437006000 Walker B; other site 511437006001 D-loop; other site 511437006002 H-loop/switch region; other site 511437006003 Cobalt transport protein; Region: CbiQ; cl00463 511437006004 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 511437006005 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 511437006006 active site 511437006007 homotetramer interface [polypeptide binding]; other site 511437006008 homodimer interface [polypeptide binding]; other site 511437006009 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 511437006010 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 511437006011 Walker A/P-loop; other site 511437006012 ATP binding site [chemical binding]; other site 511437006013 Q-loop/lid; other site 511437006014 ABC transporter signature motif; other site 511437006015 Walker B; other site 511437006016 D-loop; other site 511437006017 H-loop/switch region; other site 511437006018 TOBE domain; Region: TOBE_2; pfam08402 511437006019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437006020 dimer interface [polypeptide binding]; other site 511437006021 conserved gate region; other site 511437006022 putative PBP binding loops; other site 511437006023 ABC-ATPase subunit interface; other site 511437006024 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 511437006025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437006026 dimer interface [polypeptide binding]; other site 511437006027 conserved gate region; other site 511437006028 putative PBP binding loops; other site 511437006029 ABC-ATPase subunit interface; other site 511437006030 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 511437006031 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 511437006032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006033 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006034 putative substrate translocation pore; other site 511437006035 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 511437006036 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 511437006037 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437006038 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 511437006039 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437006040 motif II; other site 511437006041 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 511437006042 putative phosphoketolase; Provisional; Region: PRK05261 511437006043 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 511437006044 TPP-binding site; other site 511437006045 XFP C-terminal domain; Region: XFP_C; pfam09363 511437006046 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 511437006047 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 511437006048 active site 511437006049 metal binding site [ion binding]; metal-binding site 511437006050 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 511437006051 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 511437006052 aromatic amino acid aminotransferase; Validated; Region: PRK07309 511437006053 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437006054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437006055 homodimer interface [polypeptide binding]; other site 511437006056 catalytic residue [active] 511437006057 dihydrodipicolinate reductase; Provisional; Region: PRK00048 511437006058 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 511437006059 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 511437006060 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 511437006061 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 511437006062 dimer interface [polypeptide binding]; other site 511437006063 active site 511437006064 catalytic residue [active] 511437006065 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 511437006066 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 511437006067 metal binding site [ion binding]; metal-binding site 511437006068 putative dimer interface [polypeptide binding]; other site 511437006069 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 511437006070 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 511437006071 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 511437006072 putative trimer interface [polypeptide binding]; other site 511437006073 putative CoA binding site [chemical binding]; other site 511437006074 diaminopimelate decarboxylase; Region: lysA; TIGR01048 511437006075 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 511437006076 active site 511437006077 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511437006078 substrate binding site [chemical binding]; other site 511437006079 catalytic residues [active] 511437006080 dimer interface [polypeptide binding]; other site 511437006081 aspartate kinase; Reviewed; Region: PRK09034 511437006082 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 511437006083 putative catalytic residues [active] 511437006084 putative nucleotide binding site [chemical binding]; other site 511437006085 putative aspartate binding site [chemical binding]; other site 511437006086 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 511437006087 allosteric regulatory residue; other site 511437006088 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 511437006089 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 511437006090 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 511437006091 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 511437006092 6-phosphofructokinase 2; Provisional; Region: PRK10294 511437006093 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 511437006094 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 511437006095 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 511437006096 DEAD_2; Region: DEAD_2; pfam06733 511437006097 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 511437006098 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 511437006099 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 511437006100 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 511437006101 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 511437006102 metal binding site 2 [ion binding]; metal-binding site 511437006103 putative DNA binding helix; other site 511437006104 metal binding site 1 [ion binding]; metal-binding site 511437006105 dimer interface [polypeptide binding]; other site 511437006106 structural Zn2+ binding site [ion binding]; other site 511437006107 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 511437006108 amidase catalytic site [active] 511437006109 Zn binding residues [ion binding]; other site 511437006110 substrate binding site [chemical binding]; other site 511437006111 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 511437006112 nucleotide binding site [chemical binding]; other site 511437006113 homotetrameric interface [polypeptide binding]; other site 511437006114 putative phosphate binding site [ion binding]; other site 511437006115 putative allosteric binding site; other site 511437006116 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 511437006117 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 511437006118 putative catalytic cysteine [active] 511437006119 Transcriptional regulators [Transcription]; Region: MarR; COG1846 511437006120 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511437006121 putative DNA binding site [nucleotide binding]; other site 511437006122 putative Zn2+ binding site [ion binding]; other site 511437006123 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 511437006124 active site residue [active] 511437006125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437006126 dimer interface [polypeptide binding]; other site 511437006127 conserved gate region; other site 511437006128 ABC-ATPase subunit interface; other site 511437006129 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 511437006130 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 511437006131 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511437006132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437006133 Walker A/P-loop; other site 511437006134 ATP binding site [chemical binding]; other site 511437006135 Q-loop/lid; other site 511437006136 ABC transporter signature motif; other site 511437006137 Walker B; other site 511437006138 D-loop; other site 511437006139 H-loop/switch region; other site 511437006140 YibE/F-like protein; Region: YibE_F; pfam07907 511437006141 YibE/F-like protein; Region: YibE_F; pfam07907 511437006142 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511437006143 Ligand Binding Site [chemical binding]; other site 511437006144 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 511437006145 active site 2 [active] 511437006146 active site 1 [active] 511437006147 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 511437006148 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 511437006149 putative NAD(P) binding site [chemical binding]; other site 511437006150 catalytic Zn binding site [ion binding]; other site 511437006151 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511437006152 dimerization interface [polypeptide binding]; other site 511437006153 putative DNA binding site [nucleotide binding]; other site 511437006154 putative Zn2+ binding site [ion binding]; other site 511437006155 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 511437006156 Predicted membrane protein [Function unknown]; Region: COG4392 511437006157 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 511437006158 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 511437006159 putative ADP-ribose binding site [chemical binding]; other site 511437006160 putative active site [active] 511437006161 recombination factor protein RarA; Reviewed; Region: PRK13342 511437006162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437006163 Walker A motif; other site 511437006164 ATP binding site [chemical binding]; other site 511437006165 Walker B motif; other site 511437006166 arginine finger; other site 511437006167 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 511437006168 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 511437006169 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 511437006170 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 511437006171 active site 511437006172 Zn binding site [ion binding]; other site 511437006173 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 511437006174 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511437006175 nucleotide binding site [chemical binding]; other site 511437006176 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 511437006177 active site 511437006178 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 511437006179 tetramer interfaces [polypeptide binding]; other site 511437006180 binuclear metal-binding site [ion binding]; other site 511437006181 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 511437006182 active site 511437006183 DNA binding site [nucleotide binding] 511437006184 Uncharacterized conserved protein [Function unknown]; Region: COG3189 511437006185 beta-phosphoglucomutase; Region: bPGM; TIGR01990 511437006186 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437006187 motif II; other site 511437006188 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 511437006189 dimer interface [polypeptide binding]; other site 511437006190 hypothetical protein; Provisional; Region: PRK04164 511437006191 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 511437006192 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 511437006193 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 511437006194 RNA/DNA hybrid binding site [nucleotide binding]; other site 511437006195 active site 511437006196 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 511437006197 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 511437006198 putative acyl-acceptor binding pocket; other site 511437006199 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 511437006200 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 511437006201 Ligand binding site; other site 511437006202 metal-binding site 511437006203 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 511437006204 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 511437006205 putative acyl-acceptor binding pocket; other site 511437006206 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511437006207 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511437006208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437006209 Walker A/P-loop; other site 511437006210 ATP binding site [chemical binding]; other site 511437006211 Q-loop/lid; other site 511437006212 ABC transporter signature motif; other site 511437006213 Walker B; other site 511437006214 D-loop; other site 511437006215 H-loop/switch region; other site 511437006216 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 511437006217 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 511437006218 active site 511437006219 cytosine deaminase; Provisional; Region: PRK09230 511437006220 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 511437006221 active site 511437006222 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 511437006223 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 511437006224 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 511437006225 TrkA-N domain; Region: TrkA_N; pfam02254 511437006226 TrkA-C domain; Region: TrkA_C; pfam02080 511437006227 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 511437006228 dimer interface [polypeptide binding]; other site 511437006229 substrate binding site [chemical binding]; other site 511437006230 ATP binding site [chemical binding]; other site 511437006231 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437006232 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437006233 active site 511437006234 catalytic tetrad [active] 511437006235 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 511437006236 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 511437006237 OsmC-like protein; Region: OsmC; pfam02566 511437006238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437006239 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 511437006240 Walker A motif; other site 511437006241 ATP binding site [chemical binding]; other site 511437006242 Walker B motif; other site 511437006243 arginine finger; other site 511437006244 UvrB/uvrC motif; Region: UVR; pfam02151 511437006245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437006246 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 511437006247 Walker A motif; other site 511437006248 ATP binding site [chemical binding]; other site 511437006249 Walker B motif; other site 511437006250 arginine finger; other site 511437006251 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 511437006252 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 511437006253 DNA-binding site [nucleotide binding]; DNA binding site 511437006254 RNA-binding motif; other site 511437006255 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 511437006256 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 511437006257 dimer interface [polypeptide binding]; other site 511437006258 FMN binding site [chemical binding]; other site 511437006259 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 511437006260 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 511437006261 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 511437006262 HPr interaction site; other site 511437006263 glycerol kinase (GK) interaction site [polypeptide binding]; other site 511437006264 active site 511437006265 phosphorylation site [posttranslational modification] 511437006266 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511437006267 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511437006268 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 511437006269 Walker A/P-loop; other site 511437006270 ATP binding site [chemical binding]; other site 511437006271 Q-loop/lid; other site 511437006272 ABC transporter signature motif; other site 511437006273 Walker B; other site 511437006274 D-loop; other site 511437006275 H-loop/switch region; other site 511437006276 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511437006277 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511437006278 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437006279 Walker A/P-loop; other site 511437006280 ATP binding site [chemical binding]; other site 511437006281 Q-loop/lid; other site 511437006282 ABC transporter signature motif; other site 511437006283 Walker B; other site 511437006284 D-loop; other site 511437006285 H-loop/switch region; other site 511437006286 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 511437006287 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 511437006288 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 511437006289 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 511437006290 PemK-like protein; Region: PemK; pfam02452 511437006291 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 511437006292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437006293 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 511437006294 NAD(P) binding site [chemical binding]; other site 511437006295 active site 511437006296 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 511437006297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511437006298 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 511437006299 dimerization interface [polypeptide binding]; other site 511437006300 substrate binding pocket [chemical binding]; other site 511437006301 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 511437006302 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 511437006303 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 511437006304 active site 511437006305 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 511437006306 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 511437006307 lipoyl attachment site [posttranslational modification]; other site 511437006308 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511437006309 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437006310 DNA binding site [nucleotide binding] 511437006311 domain linker motif; other site 511437006312 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 511437006313 putative dimerization interface [polypeptide binding]; other site 511437006314 putative ligand binding site [chemical binding]; other site 511437006315 fructuronate transporter; Provisional; Region: PRK10034; cl15264 511437006316 Citrate transporter; Region: CitMHS; pfam03600 511437006317 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 511437006318 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 511437006319 NADP binding site [chemical binding]; other site 511437006320 homodimer interface [polypeptide binding]; other site 511437006321 active site 511437006322 EDD domain protein, DegV family; Region: DegV; TIGR00762 511437006323 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 511437006324 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 511437006325 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437006326 DNA binding site [nucleotide binding] 511437006327 domain linker motif; other site 511437006328 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 511437006329 putative dimerization interface [polypeptide binding]; other site 511437006330 putative ligand binding site [chemical binding]; other site 511437006331 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 511437006332 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 511437006333 active site 511437006334 substrate binding site [chemical binding]; other site 511437006335 metal binding site [ion binding]; metal-binding site 511437006336 CAAX protease self-immunity; Region: Abi; pfam02517 511437006337 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 511437006338 active site 511437006339 putative catalytic site [active] 511437006340 DNA binding site [nucleotide binding] 511437006341 putative phosphate binding site [ion binding]; other site 511437006342 metal binding site A [ion binding]; metal-binding site 511437006343 AP binding site [nucleotide binding]; other site 511437006344 metal binding site B [ion binding]; metal-binding site 511437006345 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 511437006346 EDD domain protein, DegV family; Region: DegV; TIGR00762 511437006347 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 511437006348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006349 putative substrate translocation pore; other site 511437006350 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006351 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 511437006352 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 511437006353 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 511437006354 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437006355 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437006356 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 511437006357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437006358 Walker A/P-loop; other site 511437006359 ATP binding site [chemical binding]; other site 511437006360 Q-loop/lid; other site 511437006361 ABC transporter signature motif; other site 511437006362 Walker B; other site 511437006363 D-loop; other site 511437006364 H-loop/switch region; other site 511437006365 ABC transporter; Region: ABC_tran_2; pfam12848 511437006366 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511437006367 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437006368 catalytic core [active] 511437006369 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 511437006370 ZIP Zinc transporter; Region: Zip; pfam02535 511437006371 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437006372 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437006373 active site 511437006374 catalytic tetrad [active] 511437006375 maltose O-acetyltransferase; Provisional; Region: PRK10092 511437006376 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 511437006377 active site 511437006378 substrate binding site [chemical binding]; other site 511437006379 trimer interface [polypeptide binding]; other site 511437006380 CoA binding site [chemical binding]; other site 511437006381 L-arabinose isomerase; Provisional; Region: PRK02929 511437006382 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 511437006383 hexamer (dimer of trimers) interface [polypeptide binding]; other site 511437006384 substrate binding site [chemical binding]; other site 511437006385 trimer interface [polypeptide binding]; other site 511437006386 Mn binding site [ion binding]; other site 511437006387 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 511437006388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006389 putative substrate translocation pore; other site 511437006390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006391 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511437006392 DNA-binding site [nucleotide binding]; DNA binding site 511437006393 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511437006394 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 511437006395 putative dimerization interface [polypeptide binding]; other site 511437006396 putative ligand binding site [chemical binding]; other site 511437006397 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 511437006398 active site 511437006399 catalytic residues [active] 511437006400 Acetokinase family; Region: Acetate_kinase; cl17229 511437006401 propionate/acetate kinase; Provisional; Region: PRK12379 511437006402 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 511437006403 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 511437006404 N- and C-terminal domain interface [polypeptide binding]; other site 511437006405 active site 511437006406 catalytic site [active] 511437006407 metal binding site [ion binding]; metal-binding site 511437006408 carbohydrate binding site [chemical binding]; other site 511437006409 ATP binding site [chemical binding]; other site 511437006410 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_12; cd12177 511437006411 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 511437006412 putative ligand binding site [chemical binding]; other site 511437006413 putative NAD binding site [chemical binding]; other site 511437006414 catalytic site [active] 511437006415 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 511437006416 Glucuronate isomerase; Region: UxaC; pfam02614 511437006417 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 511437006418 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 511437006419 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 511437006420 Transcriptional regulators [Transcription]; Region: GntR; COG1802 511437006421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511437006422 DNA-binding site [nucleotide binding]; DNA binding site 511437006423 FCD domain; Region: FCD; pfam07729 511437006424 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 511437006425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006426 putative substrate translocation pore; other site 511437006427 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006428 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 511437006429 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 511437006430 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 511437006431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006432 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 511437006433 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 511437006434 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 511437006435 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 511437006436 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 511437006437 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 511437006438 active site 511437006439 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 511437006440 NlpC/P60 family; Region: NLPC_P60; pfam00877 511437006441 OsmC-like protein; Region: OsmC; cl00767 511437006442 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006444 amino acid transporter; Region: 2A0306; TIGR00909 511437006445 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 511437006446 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 511437006447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 511437006448 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 511437006449 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 511437006450 putative NAD(P) binding site [chemical binding]; other site 511437006451 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 511437006452 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 511437006453 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 511437006454 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511437006455 Ligand Binding Site [chemical binding]; other site 511437006456 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 511437006457 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 511437006458 active site 511437006459 amidase; Provisional; Region: PRK06529 511437006460 Amidase; Region: Amidase; cl11426 511437006461 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 511437006462 catalytic triad [active] 511437006463 putative active site [active] 511437006464 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 511437006465 putative phosphoketolase; Provisional; Region: PRK05261 511437006466 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 511437006467 TPP-binding site; other site 511437006468 XFP C-terminal domain; Region: XFP_C; pfam09363 511437006469 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 511437006470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006471 putative substrate translocation pore; other site 511437006472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511437006473 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 511437006474 DNA-binding site [nucleotide binding]; DNA binding site 511437006475 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 511437006476 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 511437006477 putative deacylase active site [active] 511437006478 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 511437006479 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511437006480 Zn2+ binding site [ion binding]; other site 511437006481 Mg2+ binding site [ion binding]; other site 511437006482 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 511437006483 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 511437006484 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 511437006485 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 511437006486 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 511437006487 putative catalytic cysteine [active] 511437006488 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 511437006489 putative active site [active] 511437006490 metal binding site [ion binding]; metal-binding site 511437006491 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 511437006492 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437006493 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 511437006494 Soluble P-type ATPase [General function prediction only]; Region: COG4087 511437006495 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437006496 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437006497 active site 511437006498 catalytic tetrad [active] 511437006499 maltose O-acetyltransferase; Provisional; Region: PRK10092 511437006500 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 511437006501 active site 511437006502 substrate binding site [chemical binding]; other site 511437006503 trimer interface [polypeptide binding]; other site 511437006504 CoA binding site [chemical binding]; other site 511437006505 Predicted permeases [General function prediction only]; Region: COG0679 511437006506 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 511437006507 Domain of unknown function DUF21; Region: DUF21; pfam01595 511437006508 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 511437006509 Transporter associated domain; Region: CorC_HlyC; smart01091 511437006510 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 511437006511 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 511437006512 flavoprotein NrdI; Provisional; Region: PRK02551 511437006513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006514 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006515 putative substrate translocation pore; other site 511437006516 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 511437006517 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 511437006518 active site 511437006519 substrate binding site [chemical binding]; other site 511437006520 trimer interface [polypeptide binding]; other site 511437006521 CoA binding site [chemical binding]; other site 511437006522 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 511437006523 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 511437006524 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 511437006525 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 511437006526 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 511437006527 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 511437006528 PemK-like protein; Region: PemK; cl00995 511437006529 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 511437006530 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 511437006531 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511437006532 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 511437006533 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 511437006534 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 511437006535 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 511437006536 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 511437006537 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 511437006538 Abi-like protein; Region: Abi_2; pfam07751 511437006539 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437006540 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437006541 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 511437006542 thiamine phosphate binding site [chemical binding]; other site 511437006543 active site 511437006544 pyrophosphate binding site [ion binding]; other site 511437006545 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 511437006546 thiS-thiF/thiG interaction site; other site 511437006547 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 511437006548 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 511437006549 putative ATP binding site [chemical binding]; other site 511437006550 putative substrate interface [chemical binding]; other site 511437006551 thiazole synthase; Reviewed; Region: thiG; PRK00208 511437006552 phosphate binding site [ion binding]; other site 511437006553 allantoate amidohydrolase; Reviewed; Region: PRK09290 511437006554 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 511437006555 active site 511437006556 metal binding site [ion binding]; metal-binding site 511437006557 dimer interface [polypeptide binding]; other site 511437006558 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 511437006559 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 511437006560 multicopper oxidase; Provisional; Region: PRK10965 511437006561 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 511437006562 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 511437006563 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437006564 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437006565 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 511437006566 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 511437006567 putative acyltransferase; Provisional; Region: PRK05790 511437006568 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 511437006569 dimer interface [polypeptide binding]; other site 511437006570 active site 511437006571 CsbD-like; Region: CsbD; cl17424 511437006572 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 511437006573 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 511437006574 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 511437006575 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 511437006576 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 511437006577 homodimer interface [polypeptide binding]; other site 511437006578 substrate-cofactor binding pocket; other site 511437006579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437006580 catalytic residue [active] 511437006581 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 511437006582 Part of AAA domain; Region: AAA_19; pfam13245 511437006583 Family description; Region: UvrD_C_2; pfam13538 511437006584 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 511437006585 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 511437006586 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 511437006587 NADH(P)-binding; Region: NAD_binding_10; pfam13460 511437006588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437006589 NAD(P) binding site [chemical binding]; other site 511437006590 active site 511437006591 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437006592 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437006593 active site 511437006594 catalytic tetrad [active] 511437006595 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437006596 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 511437006597 NAD(P) binding site [chemical binding]; other site 511437006598 active site 511437006599 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 511437006600 QueT transporter; Region: QueT; pfam06177 511437006601 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 511437006602 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 511437006603 dimer interface [polypeptide binding]; other site 511437006604 active site 511437006605 metal binding site [ion binding]; metal-binding site 511437006606 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 511437006607 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 511437006608 putative NAD(P) binding site [chemical binding]; other site 511437006609 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 511437006610 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 511437006611 synthetase active site [active] 511437006612 NTP binding site [chemical binding]; other site 511437006613 metal binding site [ion binding]; metal-binding site 511437006614 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 511437006615 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 511437006616 putative active site [active] 511437006617 catalytic site [active] 511437006618 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 511437006619 putative active site [active] 511437006620 catalytic site [active] 511437006621 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 511437006622 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 511437006623 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511437006624 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 511437006625 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 511437006626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006627 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006628 putative substrate translocation pore; other site 511437006629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006630 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006631 putative substrate translocation pore; other site 511437006632 Methyltransferase domain; Region: Methyltransf_31; pfam13847 511437006633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437006634 S-adenosylmethionine binding site [chemical binding]; other site 511437006635 Predicted amidohydrolase [General function prediction only]; Region: COG0388 511437006636 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 511437006637 putative active site [active] 511437006638 catalytic triad [active] 511437006639 putative dimer interface [polypeptide binding]; other site 511437006640 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 511437006641 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 511437006642 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 511437006643 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 511437006644 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 511437006645 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 511437006646 active site 511437006647 ribulose/triose binding site [chemical binding]; other site 511437006648 phosphate binding site [ion binding]; other site 511437006649 substrate (anthranilate) binding pocket [chemical binding]; other site 511437006650 product (indole) binding pocket [chemical binding]; other site 511437006651 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 511437006652 active site 511437006653 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 511437006654 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 511437006655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437006656 catalytic residue [active] 511437006657 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 511437006658 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 511437006659 substrate binding site [chemical binding]; other site 511437006660 active site 511437006661 catalytic residues [active] 511437006662 heterodimer interface [polypeptide binding]; other site 511437006663 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 511437006664 Predicted flavoprotein [General function prediction only]; Region: COG0431 511437006665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437006666 non-specific DNA binding site [nucleotide binding]; other site 511437006667 salt bridge; other site 511437006668 sequence-specific DNA binding site [nucleotide binding]; other site 511437006669 stage V sporulation protein B; Region: spore_V_B; TIGR02900 511437006670 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 511437006671 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437006672 non-specific DNA binding site [nucleotide binding]; other site 511437006673 salt bridge; other site 511437006674 sequence-specific DNA binding site [nucleotide binding]; other site 511437006675 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 511437006676 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 511437006677 N-terminal domain interface [polypeptide binding]; other site 511437006678 dimer interface [polypeptide binding]; other site 511437006679 substrate binding pocket (H-site) [chemical binding]; other site 511437006680 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 511437006681 peptidase domain interface [polypeptide binding]; other site 511437006682 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 511437006683 active site 511437006684 catalytic triad [active] 511437006685 calcium binding site [ion binding]; other site 511437006686 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 511437006687 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 511437006688 peptide binding site [polypeptide binding]; other site 511437006689 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 511437006690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437006691 dimer interface [polypeptide binding]; other site 511437006692 conserved gate region; other site 511437006693 putative PBP binding loops; other site 511437006694 ABC-ATPase subunit interface; other site 511437006695 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 511437006696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437006697 dimer interface [polypeptide binding]; other site 511437006698 conserved gate region; other site 511437006699 putative PBP binding loops; other site 511437006700 ABC-ATPase subunit interface; other site 511437006701 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 511437006702 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511437006703 Walker A/P-loop; other site 511437006704 ATP binding site [chemical binding]; other site 511437006705 Q-loop/lid; other site 511437006706 ABC transporter signature motif; other site 511437006707 Walker B; other site 511437006708 D-loop; other site 511437006709 H-loop/switch region; other site 511437006710 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511437006711 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 511437006712 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511437006713 Walker A/P-loop; other site 511437006714 ATP binding site [chemical binding]; other site 511437006715 Q-loop/lid; other site 511437006716 ABC transporter signature motif; other site 511437006717 Walker B; other site 511437006718 D-loop; other site 511437006719 H-loop/switch region; other site 511437006720 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511437006721 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437006722 Helix-turn-helix domain; Region: HTH_38; pfam13936 511437006723 Integrase core domain; Region: rve; pfam00665 511437006724 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 511437006725 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 511437006726 active site 511437006727 Collagen binding domain; Region: Collagen_bind; pfam05737 511437006728 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 511437006729 domain interaction interfaces [polypeptide binding]; other site 511437006730 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 511437006731 domain interaction interfaces [polypeptide binding]; other site 511437006732 conserved hypothetical integral membrane protein; Region: TIGR03766 511437006733 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 511437006734 NADH(P)-binding; Region: NAD_binding_10; pfam13460 511437006735 NAD binding site [chemical binding]; other site 511437006736 substrate binding site [chemical binding]; other site 511437006737 putative active site [active] 511437006738 maltose phosphorylase; Provisional; Region: PRK13807 511437006739 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 511437006740 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 511437006741 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 511437006742 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006744 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 511437006745 ROK family; Region: ROK; pfam00480 511437006746 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 511437006747 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 511437006748 putative NAD(P) binding site [chemical binding]; other site 511437006749 catalytic Zn binding site [ion binding]; other site 511437006750 Predicted membrane protein [Function unknown]; Region: COG2364 511437006751 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 511437006752 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 511437006753 active site 511437006754 metal binding site [ion binding]; metal-binding site 511437006755 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 511437006756 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 511437006757 active site 511437006758 dimer interface [polypeptide binding]; other site 511437006759 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 511437006760 dimer interface [polypeptide binding]; other site 511437006761 active site 511437006762 H+ Antiporter protein; Region: 2A0121; TIGR00900 511437006763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511437006764 Helix-turn-helix domain; Region: HTH_28; pfam13518 511437006765 Helix-turn-helix domain; Region: HTH_28; pfam13518 511437006766 putative transposase OrfB; Reviewed; Region: PHA02517 511437006767 HTH-like domain; Region: HTH_21; pfam13276 511437006768 Integrase core domain; Region: rve; pfam00665 511437006769 Integrase core domain; Region: rve_3; pfam13683 511437006770 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511437006771 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437006772 DNA binding site [nucleotide binding] 511437006773 domain linker motif; other site 511437006774 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 511437006775 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 511437006776 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 511437006777 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 511437006778 putative active site [active] 511437006779 catalytic site [active] 511437006780 putative metal binding site [ion binding]; other site 511437006781 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 511437006782 trimer interface [polypeptide binding]; other site 511437006783 active site 511437006784 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 511437006785 hypothetical protein; Provisional; Region: PRK13690 511437006786 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 511437006787 substrate binding site [chemical binding]; other site 511437006788 ATP binding site [chemical binding]; other site 511437006789 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 511437006790 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 511437006791 substrate binding site [chemical binding]; other site 511437006792 THF binding site; other site 511437006793 zinc-binding site [ion binding]; other site 511437006794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006795 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006796 putative substrate translocation pore; other site 511437006797 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 511437006798 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 511437006799 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437006800 Walker A/P-loop; other site 511437006801 ATP binding site [chemical binding]; other site 511437006802 Q-loop/lid; other site 511437006803 ABC transporter signature motif; other site 511437006804 Walker B; other site 511437006805 D-loop; other site 511437006806 H-loop/switch region; other site 511437006807 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 511437006808 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437006809 active site 511437006810 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 511437006811 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 511437006812 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 511437006813 D-lactate dehydrogenase; Validated; Region: PRK08605 511437006814 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 511437006815 homodimer interface [polypeptide binding]; other site 511437006816 ligand binding site [chemical binding]; other site 511437006817 NAD binding site [chemical binding]; other site 511437006818 catalytic site [active] 511437006819 malate dehydrogenase; Provisional; Region: PRK13529 511437006820 Malic enzyme, N-terminal domain; Region: malic; pfam00390 511437006821 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 511437006822 NAD(P) binding site [chemical binding]; other site 511437006823 fumarate hydratase; Reviewed; Region: fumC; PRK00485 511437006824 Class II fumarases; Region: Fumarase_classII; cd01362 511437006825 active site 511437006826 tetramer interface [polypeptide binding]; other site 511437006827 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 511437006828 active site residue [active] 511437006829 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 511437006830 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 511437006831 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511437006832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437006833 non-specific DNA binding site [nucleotide binding]; other site 511437006834 salt bridge; other site 511437006835 sequence-specific DNA binding site [nucleotide binding]; other site 511437006836 CAAX protease self-immunity; Region: Abi; pfam02517 511437006837 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 511437006838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511437006839 Walker A/P-loop; other site 511437006840 ATP binding site [chemical binding]; other site 511437006841 Q-loop/lid; other site 511437006842 ABC transporter signature motif; other site 511437006843 Walker B; other site 511437006844 D-loop; other site 511437006845 H-loop/switch region; other site 511437006846 Predicted transcriptional regulators [Transcription]; Region: COG1725 511437006847 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511437006848 DNA-binding site [nucleotide binding]; DNA binding site 511437006849 Helix-turn-helix domain; Region: HTH_38; pfam13936 511437006850 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437006851 Integrase core domain; Region: rve; pfam00665 511437006852 Integrase core domain; Region: rve_3; cl15866 511437006853 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 511437006854 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511437006855 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 511437006856 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437006857 Helix-turn-helix domain; Region: HTH_38; pfam13936 511437006858 Integrase core domain; Region: rve; pfam00665 511437006859 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511437006860 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437006861 non-specific DNA binding site [nucleotide binding]; other site 511437006862 salt bridge; other site 511437006863 sequence-specific DNA binding site [nucleotide binding]; other site 511437006864 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 511437006865 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437006866 non-specific DNA binding site [nucleotide binding]; other site 511437006867 salt bridge; other site 511437006868 sequence-specific DNA binding site [nucleotide binding]; other site 511437006869 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 511437006870 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 511437006871 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 511437006872 Predicted transcriptional regulator [Transcription]; Region: COG3655 511437006873 non-specific DNA binding site [nucleotide binding]; other site 511437006874 salt bridge; other site 511437006875 sequence-specific DNA binding site [nucleotide binding]; other site 511437006876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006877 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006878 putative substrate translocation pore; other site 511437006879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006880 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 511437006881 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 511437006882 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437006883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437006884 homodimer interface [polypeptide binding]; other site 511437006885 catalytic residue [active] 511437006886 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 511437006887 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 511437006888 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 511437006889 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 511437006890 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 511437006891 gating phenylalanine in ion channel; other site 511437006892 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511437006893 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511437006894 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511437006895 dimerization interface [polypeptide binding]; other site 511437006896 aspartate kinase; Reviewed; Region: PRK09034 511437006897 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 511437006898 nucleotide binding site [chemical binding]; other site 511437006899 substrate binding site [chemical binding]; other site 511437006900 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 511437006901 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 511437006902 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 511437006903 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 511437006904 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 511437006905 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 511437006906 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 511437006907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437006908 catalytic residue [active] 511437006909 homoserine kinase; Provisional; Region: PRK01212 511437006910 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511437006911 hypothetical protein; Provisional; Region: PRK04435 511437006912 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 511437006913 DNA-binding interface [nucleotide binding]; DNA binding site 511437006914 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 511437006915 Uncharacterized conserved protein [Function unknown]; Region: COG2966 511437006916 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 511437006917 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 511437006918 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 511437006919 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 511437006920 putative NAD(P) binding site [chemical binding]; other site 511437006921 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 511437006922 Putative esterase; Region: Esterase; pfam00756 511437006923 S-formylglutathione hydrolase; Region: PLN02442 511437006924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 511437006925 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 511437006926 HTH domain; Region: HTH_11; cl17392 511437006927 amino acid transporter; Region: 2A0306; TIGR00909 511437006928 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 511437006929 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 511437006930 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 511437006931 inhibitor-cofactor binding pocket; inhibition site 511437006932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437006933 catalytic residue [active] 511437006934 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 511437006935 putative catalytic site [active] 511437006936 putative metal binding site [ion binding]; other site 511437006937 putative phosphate binding site [ion binding]; other site 511437006938 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437006939 catalytic core [active] 511437006940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006941 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006942 putative substrate translocation pore; other site 511437006943 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 511437006944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437006945 Coenzyme A binding pocket [chemical binding]; other site 511437006946 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 511437006947 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 511437006948 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 511437006949 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 511437006950 Helix-turn-helix domain; Region: HTH_38; pfam13936 511437006951 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437006952 Integrase core domain; Region: rve; pfam00665 511437006953 Integrase core domain; Region: rve_3; cl15866 511437006954 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 511437006955 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 511437006956 active site 511437006957 pyruvate oxidase; Provisional; Region: PRK08611 511437006958 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 511437006959 PYR/PP interface [polypeptide binding]; other site 511437006960 dimer interface [polypeptide binding]; other site 511437006961 tetramer interface [polypeptide binding]; other site 511437006962 TPP binding site [chemical binding]; other site 511437006963 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 511437006964 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 511437006965 TPP-binding site [chemical binding]; other site 511437006966 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 511437006967 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 511437006968 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 511437006969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006970 putative substrate translocation pore; other site 511437006971 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 511437006972 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 511437006973 putative NAD(P) binding site [chemical binding]; other site 511437006974 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 511437006975 PhoU domain; Region: PhoU; pfam01895 511437006976 PhoU domain; Region: PhoU; pfam01895 511437006977 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 511437006978 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 511437006979 Walker A/P-loop; other site 511437006980 ATP binding site [chemical binding]; other site 511437006981 Q-loop/lid; other site 511437006982 ABC transporter signature motif; other site 511437006983 Walker B; other site 511437006984 D-loop; other site 511437006985 H-loop/switch region; other site 511437006986 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 511437006987 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 511437006988 Walker A/P-loop; other site 511437006989 ATP binding site [chemical binding]; other site 511437006990 Q-loop/lid; other site 511437006991 ABC transporter signature motif; other site 511437006992 Walker B; other site 511437006993 D-loop; other site 511437006994 H-loop/switch region; other site 511437006995 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 511437006996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437006997 dimer interface [polypeptide binding]; other site 511437006998 conserved gate region; other site 511437006999 putative PBP binding loops; other site 511437007000 ABC-ATPase subunit interface; other site 511437007001 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 511437007002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437007003 dimer interface [polypeptide binding]; other site 511437007004 conserved gate region; other site 511437007005 putative PBP binding loops; other site 511437007006 ABC-ATPase subunit interface; other site 511437007007 PBP superfamily domain; Region: PBP_like_2; cl17296 511437007008 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 511437007009 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511437007010 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511437007011 DNA binding site [nucleotide binding] 511437007012 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 511437007013 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 511437007014 active site 511437007015 dimer interface [polypeptide binding]; other site 511437007016 metal binding site [ion binding]; metal-binding site 511437007017 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 511437007018 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 511437007019 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 511437007020 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 511437007021 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 511437007022 Glutamine amidotransferase class-I; Region: GATase; pfam00117 511437007023 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 511437007024 glutamine binding [chemical binding]; other site 511437007025 catalytic triad [active] 511437007026 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 511437007027 acetylornithine deacetylase; Validated; Region: PRK08596 511437007028 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 511437007029 metal binding site [ion binding]; metal-binding site 511437007030 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 511437007031 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 511437007032 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437007033 catalytic core [active] 511437007034 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 511437007035 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 511437007036 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 511437007037 Catalytic site [active] 511437007038 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 511437007039 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 511437007040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437007041 putative substrate translocation pore; other site 511437007042 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 511437007043 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 511437007044 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 511437007045 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 511437007046 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 511437007047 trmE is a tRNA modification GTPase; Region: trmE; cd04164 511437007048 G1 box; other site 511437007049 GTP/Mg2+ binding site [chemical binding]; other site 511437007050 Switch I region; other site 511437007051 G2 box; other site 511437007052 Switch II region; other site 511437007053 G3 box; other site 511437007054 G4 box; other site 511437007055 G5 box; other site 511437007056 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 511437007057 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 511437007058 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 511437007059 G-X-X-G motif; other site 511437007060 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 511437007061 RxxxH motif; other site 511437007062 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 511437007063 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 511437007064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437007065 acetoin reductases; Region: 23BDH; TIGR02415 511437007066 NAD(P) binding site [chemical binding]; other site 511437007067 active site 511437007068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511437007069 Helix-turn-helix domain; Region: HTH_28; pfam13518 511437007070 Helix-turn-helix domain; Region: HTH_28; pfam13518 511437007071 putative transposase OrfB; Reviewed; Region: PHA02517 511437007072 HTH-like domain; Region: HTH_21; pfam13276 511437007073 Integrase core domain; Region: rve; pfam00665 511437007074 Integrase core domain; Region: rve_3; pfam13683 511437007075 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 511437007076 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 511437007077 putative NAD(P) binding site [chemical binding]; other site 511437007078 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511437007079 dimerization interface [polypeptide binding]; other site 511437007080 putative DNA binding site [nucleotide binding]; other site 511437007081 putative Zn2+ binding site [ion binding]; other site 511437007082 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 511437007083 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 511437007084 potential catalytic triad [active] 511437007085 conserved cys residue [active] 511437007086 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 511437007087 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 511437007088 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 511437007089 ribonuclease P; Reviewed; Region: rnpA; PRK00499 511437007090 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 511437007091 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 511437007092 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 511437007093 P-loop; other site 511437007094 Magnesium ion binding site [ion binding]; other site 511437007095 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 511437007096 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 511437007097 Magnesium ion binding site [ion binding]; other site 511437007098 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 511437007099 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 511437007100 catalytic residues [active] 511437007101 catalytic nucleophile [active] 511437007102 Presynaptic Site I dimer interface [polypeptide binding]; other site 511437007103 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 511437007104 Synaptic Flat tetramer interface [polypeptide binding]; other site 511437007105 Synaptic Site I dimer interface [polypeptide binding]; other site 511437007106 DNA binding site [nucleotide binding] 511437007107 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 511437007108 DNA-binding interface [nucleotide binding]; DNA binding site 511437007109 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511437007110 dimerization interface [polypeptide binding]; other site 511437007111 putative DNA binding site [nucleotide binding]; other site 511437007112 putative Zn2+ binding site [ion binding]; other site 511437007113 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 511437007114 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437007115 Soluble P-type ATPase [General function prediction only]; Region: COG4087 511437007116 DDE domain; Region: DDE_Tnp_IS240; pfam13610 511437007117 Integrase core domain; Region: rve; pfam00665 511437007118 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 511437007119 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437007120 Soluble P-type ATPase [General function prediction only]; Region: COG4087 511437007121 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437007122 Helix-turn-helix domain; Region: HTH_38; pfam13936 511437007123 Integrase core domain; Region: rve; pfam00665 511437007124 putative transposase OrfB; Reviewed; Region: PHA02517 511437007125 HTH-like domain; Region: HTH_21; pfam13276 511437007126 Integrase core domain; Region: rve; pfam00665 511437007127 Integrase core domain; Region: rve_3; pfam13683 511437007128 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511437007129 Transposase; Region: HTH_Tnp_1; pfam01527 511437007130 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 511437007131 active site 511437007132 putative interdomain interaction site [polypeptide binding]; other site 511437007133 putative metal-binding site [ion binding]; other site 511437007134 putative nucleotide binding site [chemical binding]; other site 511437007135 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 511437007136 domain I; other site 511437007137 MobA/MobL family; Region: MobA_MobL; pfam03389 511437007138 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 511437007139 Zeta toxin; Region: Zeta_toxin; pfam06414 511437007140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 511437007141 RelB antitoxin; Region: RelB; cl01171 511437007142 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970