-- dump date 20140619_122219 -- class Genbank::misc_feature -- table misc_feature_note -- id note 983544000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 983544000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 983544000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983544000004 Walker A motif; other site 983544000005 ATP binding site [chemical binding]; other site 983544000006 Walker B motif; other site 983544000007 arginine finger; other site 983544000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 983544000009 DnaA box-binding interface [nucleotide binding]; other site 983544000010 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 983544000011 Low molecular weight phosphatase family; Region: LMWPc; cd00115 983544000012 active site 983544000013 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 983544000014 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544000015 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 983544000016 putative SAM binding site [chemical binding]; other site 983544000017 homodimer interface [polypeptide binding]; other site 983544000018 YceG-like family; Region: YceG; pfam02618 983544000019 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 983544000020 dimerization interface [polypeptide binding]; other site 983544000021 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 983544000022 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 983544000023 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 983544000024 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 983544000025 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 983544000026 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 983544000027 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 983544000028 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 983544000029 protein binding site [polypeptide binding]; other site 983544000030 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 983544000031 protein binding site [polypeptide binding]; other site 983544000032 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 983544000033 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 983544000034 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 983544000035 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 983544000036 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983544000037 dimerization interface [polypeptide binding]; other site 983544000038 putative DNA binding site [nucleotide binding]; other site 983544000039 putative Zn2+ binding site [ion binding]; other site 983544000040 Low molecular weight phosphatase family; Region: LMWPc; cl00105 983544000041 active site 983544000042 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 983544000043 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 983544000044 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 983544000045 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 983544000046 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 983544000047 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 983544000048 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 983544000049 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 983544000050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983544000051 TPR motif; other site 983544000052 binding surface 983544000053 TPR repeat; Region: TPR_11; pfam13414 983544000054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544000055 binding surface 983544000056 TPR motif; other site 983544000057 WYL domain; Region: WYL; pfam13280 983544000058 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 983544000059 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544000060 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544000061 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983544000062 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 983544000063 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 983544000064 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 983544000065 putative active site [active] 983544000066 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 983544000067 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 983544000068 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 983544000069 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 983544000070 active site 983544000071 dimer interface [polypeptide binding]; other site 983544000072 motif 1; other site 983544000073 motif 2; other site 983544000074 motif 3; other site 983544000075 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 983544000076 anticodon binding site; other site 983544000077 translation initiation factor IF-3; Region: infC; TIGR00168 983544000078 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 983544000079 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 983544000080 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 983544000081 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 983544000082 23S rRNA binding site [nucleotide binding]; other site 983544000083 L21 binding site [polypeptide binding]; other site 983544000084 L13 binding site [polypeptide binding]; other site 983544000085 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 983544000086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983544000087 active site 983544000088 motif I; other site 983544000089 motif II; other site 983544000090 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 983544000091 cyclase homology domain; Region: CHD; cd07302 983544000092 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 983544000093 nucleotidyl binding site; other site 983544000094 metal binding site [ion binding]; metal-binding site 983544000095 dimer interface [polypeptide binding]; other site 983544000096 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 983544000097 EF-hand domain pair; Region: EF_hand_5; pfam13499 983544000098 Ca2+ binding site [ion binding]; other site 983544000099 Domain of unknown function DUF20; Region: UPF0118; pfam01594 983544000100 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 983544000101 replicative DNA helicase; Region: DnaB; TIGR00665 983544000102 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 983544000103 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 983544000104 Walker A motif; other site 983544000105 ATP binding site [chemical binding]; other site 983544000106 Walker B motif; other site 983544000107 DNA binding loops [nucleotide binding] 983544000108 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 983544000109 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 983544000110 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 983544000111 EamA-like transporter family; Region: EamA; cl17759 983544000112 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 983544000113 Predicted permeases [General function prediction only]; Region: COG0795 983544000114 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 983544000115 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 983544000116 transketolase; Reviewed; Region: PRK05899 983544000117 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 983544000118 TPP-binding site [chemical binding]; other site 983544000119 dimer interface [polypeptide binding]; other site 983544000120 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 983544000121 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 983544000122 PYR/PP interface [polypeptide binding]; other site 983544000123 dimer interface [polypeptide binding]; other site 983544000124 TPP binding site [chemical binding]; other site 983544000125 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 983544000126 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 983544000127 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983544000128 RNA binding surface [nucleotide binding]; other site 983544000129 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 983544000130 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983544000131 active site 983544000132 shikimate kinase; Reviewed; Region: aroK; PRK00131 983544000133 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 983544000134 ADP binding site [chemical binding]; other site 983544000135 magnesium binding site [ion binding]; other site 983544000136 putative shikimate binding site; other site 983544000137 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 983544000138 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 983544000139 DNA binding residues [nucleotide binding] 983544000140 B12 binding domain; Region: B12-binding_2; pfam02607 983544000141 phytoene desaturase; Region: crtI_fam; TIGR02734 983544000142 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 983544000143 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 983544000144 active site lid residues [active] 983544000145 substrate binding pocket [chemical binding]; other site 983544000146 catalytic residues [active] 983544000147 substrate-Mg2+ binding site; other site 983544000148 aspartate-rich region 1; other site 983544000149 aspartate-rich region 2; other site 983544000150 beta-carotene hydroxylase; Region: PLN02601 983544000151 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 983544000152 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 983544000153 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 983544000154 catalytic residues [active] 983544000155 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983544000156 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 983544000157 ligand binding site [chemical binding]; other site 983544000158 flexible hinge region; other site 983544000159 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 983544000160 putative switch regulator; other site 983544000161 non-specific DNA interactions [nucleotide binding]; other site 983544000162 DNA binding site [nucleotide binding] 983544000163 sequence specific DNA binding site [nucleotide binding]; other site 983544000164 putative cAMP binding site [chemical binding]; other site 983544000165 aconitate hydratase; Validated; Region: PRK07229 983544000166 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 983544000167 substrate binding site [chemical binding]; other site 983544000168 ligand binding site [chemical binding]; other site 983544000169 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 983544000170 substrate binding site [chemical binding]; other site 983544000171 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 983544000172 Aconitate hydratase 2 N-terminus; Region: Aconitase_2_N; pfam06434 983544000173 substrate binding site [chemical binding]; other site 983544000174 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 983544000175 substrate binding site [chemical binding]; other site 983544000176 ligand binding site [chemical binding]; other site 983544000177 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 983544000178 MoxR-like ATPases [General function prediction only]; Region: COG0714 983544000179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983544000180 Walker A motif; other site 983544000181 ATP binding site [chemical binding]; other site 983544000182 Walker B motif; other site 983544000183 arginine finger; other site 983544000184 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 983544000185 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 983544000186 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 983544000187 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 983544000188 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 983544000189 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 983544000190 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 983544000191 hydrophobic ligand binding site; other site 983544000192 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 983544000193 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 983544000194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983544000195 FeS/SAM binding site; other site 983544000196 GH3 auxin-responsive promoter; Region: GH3; pfam03321 983544000197 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 983544000198 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 983544000199 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 983544000200 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 983544000201 active site 983544000202 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544000203 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 983544000204 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544000205 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 983544000206 Imelysin; Region: Peptidase_M75; pfam09375 983544000207 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 983544000208 active site 983544000209 catalytic residues [active] 983544000210 metal binding site [ion binding]; metal-binding site 983544000211 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 983544000212 Spondin_N; Region: Spond_N; pfam06468 983544000213 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544000214 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 983544000215 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 983544000216 quinone interaction residues [chemical binding]; other site 983544000217 active site 983544000218 catalytic residues [active] 983544000219 FMN binding site [chemical binding]; other site 983544000220 substrate binding site [chemical binding]; other site 983544000221 peptidase T; Region: peptidase-T; TIGR01882 983544000222 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 983544000223 metal binding site [ion binding]; metal-binding site 983544000224 dimer interface [polypeptide binding]; other site 983544000225 TPR repeat; Region: TPR_11; pfam13414 983544000226 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 983544000227 active site 983544000228 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 983544000229 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 983544000230 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 983544000231 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983544000232 ATP binding site [chemical binding]; other site 983544000233 putative Mg++ binding site [ion binding]; other site 983544000234 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983544000235 nucleotide binding region [chemical binding]; other site 983544000236 ATP-binding site [chemical binding]; other site 983544000237 RQC domain; Region: RQC; pfam09382 983544000238 HRDC domain; Region: HRDC; pfam00570 983544000239 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 983544000240 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 983544000241 putative active site [active] 983544000242 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 983544000243 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 983544000244 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 983544000245 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 983544000246 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 983544000247 Walker A/P-loop; other site 983544000248 ATP binding site [chemical binding]; other site 983544000249 Q-loop/lid; other site 983544000250 ABC transporter signature motif; other site 983544000251 Walker B; other site 983544000252 D-loop; other site 983544000253 H-loop/switch region; other site 983544000254 Integral membrane protein TerC family; Region: TerC; cl10468 983544000255 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 983544000256 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 983544000257 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 983544000258 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 983544000259 Bacterial sugar transferase; Region: Bac_transf; pfam02397 983544000260 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983544000261 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 983544000262 O-Antigen ligase; Region: Wzy_C; pfam04932 983544000263 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983544000264 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 983544000265 putative ADP-binding pocket [chemical binding]; other site 983544000266 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983544000267 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 983544000268 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 983544000269 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983544000270 active site 983544000271 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 983544000272 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 983544000273 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 983544000274 active site 983544000275 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983544000276 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 983544000277 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 983544000278 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 983544000279 Ligand binding site; other site 983544000280 Putative Catalytic site; other site 983544000281 DXD motif; other site 983544000282 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983544000283 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983544000284 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 983544000285 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 983544000286 active site 983544000287 homodimer interface [polypeptide binding]; other site 983544000288 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 983544000289 NeuB family; Region: NeuB; pfam03102 983544000290 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 983544000291 NeuB binding interface [polypeptide binding]; other site 983544000292 putative substrate binding site [chemical binding]; other site 983544000293 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 983544000294 ligand binding site; other site 983544000295 tetramer interface; other site 983544000296 Methyltransferase domain; Region: Methyltransf_24; pfam13578 983544000297 S-adenosylmethionine binding site [chemical binding]; other site 983544000298 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 983544000299 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 983544000300 active site 983544000301 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 983544000302 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983544000303 active site 983544000304 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 983544000305 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983544000306 active site 983544000307 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 983544000308 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 983544000309 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 983544000310 Walker A/P-loop; other site 983544000311 ATP binding site [chemical binding]; other site 983544000312 Q-loop/lid; other site 983544000313 ABC transporter signature motif; other site 983544000314 Walker B; other site 983544000315 D-loop; other site 983544000316 H-loop/switch region; other site 983544000317 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 983544000318 putative carbohydrate binding site [chemical binding]; other site 983544000319 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 983544000320 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 983544000321 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 983544000322 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 983544000323 NAD binding site [chemical binding]; other site 983544000324 substrate binding site [chemical binding]; other site 983544000325 homodimer interface [polypeptide binding]; other site 983544000326 active site 983544000327 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 983544000328 Chain length determinant protein; Region: Wzz; cl15801 983544000329 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 983544000330 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 983544000331 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 983544000332 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 983544000333 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 983544000334 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 983544000335 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983544000336 Walker A/P-loop; other site 983544000337 ATP binding site [chemical binding]; other site 983544000338 Q-loop/lid; other site 983544000339 ABC transporter signature motif; other site 983544000340 Walker B; other site 983544000341 D-loop; other site 983544000342 H-loop/switch region; other site 983544000343 ABC transporter; Region: ABC_tran_2; pfam12848 983544000344 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983544000345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544000346 S-adenosylmethionine binding site [chemical binding]; other site 983544000347 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 983544000348 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 983544000349 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 983544000350 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 983544000351 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 983544000352 nucleotide binding region [chemical binding]; other site 983544000353 ATP-binding site [chemical binding]; other site 983544000354 Peptidase family M23; Region: Peptidase_M23; pfam01551 983544000355 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983544000356 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544000357 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983544000358 DNA binding residues [nucleotide binding] 983544000359 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 983544000360 membrane ATPase/protein kinase; Provisional; Region: PRK09435 983544000361 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 983544000362 Walker A; other site 983544000363 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 983544000364 active site 983544000365 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 983544000366 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 983544000367 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 983544000368 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 983544000369 active site 983544000370 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 983544000371 multidrug efflux protein; Reviewed; Region: PRK01766 983544000372 cation binding site [ion binding]; other site 983544000373 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983544000374 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 983544000375 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 983544000376 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 983544000377 FMN binding site [chemical binding]; other site 983544000378 substrate binding site [chemical binding]; other site 983544000379 putative catalytic residue [active] 983544000380 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 983544000381 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 983544000382 Ligand Binding Site [chemical binding]; other site 983544000383 Fasciclin domain; Region: Fasciclin; cl02663 983544000384 Fasciclin domain; Region: Fasciclin; pfam02469 983544000385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 983544000386 membrane protein insertase; Provisional; Region: PRK01318 983544000387 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cl15675 983544000388 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 983544000389 CTP synthetase; Validated; Region: pyrG; PRK05380 983544000390 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 983544000391 Catalytic site [active] 983544000392 active site 983544000393 UTP binding site [chemical binding]; other site 983544000394 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 983544000395 active site 983544000396 putative oxyanion hole; other site 983544000397 catalytic triad [active] 983544000398 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983544000399 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983544000400 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983544000401 dimerization interface [polypeptide binding]; other site 983544000402 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 983544000403 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 983544000404 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 983544000405 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 983544000406 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 983544000407 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 983544000408 ligand binding site [chemical binding]; other site 983544000409 GMP synthase; Reviewed; Region: guaA; PRK00074 983544000410 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 983544000411 AMP/PPi binding site [chemical binding]; other site 983544000412 candidate oxyanion hole; other site 983544000413 catalytic triad [active] 983544000414 potential glutamine specificity residues [chemical binding]; other site 983544000415 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 983544000416 ATP Binding subdomain [chemical binding]; other site 983544000417 Ligand Binding sites [chemical binding]; other site 983544000418 Dimerization subdomain; other site 983544000419 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 983544000420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 983544000421 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 983544000422 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 983544000423 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983544000424 FeS/SAM binding site; other site 983544000425 amidase; Provisional; Region: PRK06707 983544000426 Amidase; Region: Amidase; cl11426 983544000427 Beta-lactamase; Region: Beta-lactamase; pfam00144 983544000428 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 983544000429 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 983544000430 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 983544000431 Interdomain contacts; other site 983544000432 Cytokine receptor motif; other site 983544000433 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 983544000434 Interdomain contacts; other site 983544000435 Cytokine receptor motif; other site 983544000436 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 983544000437 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 983544000438 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 983544000439 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 983544000440 ribosomal protein L33; Region: rpl33; CHL00104 983544000441 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 983544000442 competence damage-inducible protein A; Provisional; Region: PRK00549 983544000443 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 983544000444 putative MPT binding site; other site 983544000445 Competence-damaged protein; Region: CinA; pfam02464 983544000446 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 983544000447 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 983544000448 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 983544000449 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 983544000450 active site 983544000451 catalytic site [active] 983544000452 substrate binding site [chemical binding]; other site 983544000453 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983544000454 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 983544000455 classical (c) SDRs; Region: SDR_c; cd05233 983544000456 NAD(P) binding site [chemical binding]; other site 983544000457 active site 983544000458 Putative esterase; Region: Esterase; pfam00756 983544000459 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 983544000460 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 983544000461 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983544000462 E3 interaction surface; other site 983544000463 lipoyl attachment site [posttranslational modification]; other site 983544000464 e3 binding domain; Region: E3_binding; pfam02817 983544000465 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 983544000466 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 983544000467 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 983544000468 Probable Catalytic site; other site 983544000469 metal-binding site 983544000470 recombination protein RecR; Reviewed; Region: recR; PRK00076 983544000471 RecR protein; Region: RecR; pfam02132 983544000472 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 983544000473 putative active site [active] 983544000474 putative metal-binding site [ion binding]; other site 983544000475 tetramer interface [polypeptide binding]; other site 983544000476 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 983544000477 Na binding site [ion binding]; other site 983544000478 CoA binding domain; Region: CoA_binding_2; pfam13380 983544000479 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544000480 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983544000481 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544000482 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 983544000483 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 983544000484 dimer interface [polypeptide binding]; other site 983544000485 active site 983544000486 CoA binding pocket [chemical binding]; other site 983544000487 heat shock protein 90; Provisional; Region: PRK05218 983544000488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544000489 ATP binding site [chemical binding]; other site 983544000490 Mg2+ binding site [ion binding]; other site 983544000491 G-X-G motif; other site 983544000492 Uncharacterized conserved protein [Function unknown]; Region: COG1284 983544000493 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 983544000494 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 983544000495 pyruvate carboxylase; Reviewed; Region: PRK12999 983544000496 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 983544000497 ATP-grasp domain; Region: ATP-grasp_4; cl17255 983544000498 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 983544000499 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 983544000500 active site 983544000501 catalytic residues [active] 983544000502 metal binding site [ion binding]; metal-binding site 983544000503 homodimer binding site [polypeptide binding]; other site 983544000504 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 983544000505 carboxyltransferase (CT) interaction site; other site 983544000506 biotinylation site [posttranslational modification]; other site 983544000507 Family of unknown function (DUF695); Region: DUF695; pfam05117 983544000508 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983544000509 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 983544000510 dimer interface [polypeptide binding]; other site 983544000511 putative metal binding site [ion binding]; other site 983544000512 DinB superfamily; Region: DinB_2; pfam12867 983544000513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983544000514 non-specific DNA binding site [nucleotide binding]; other site 983544000515 salt bridge; other site 983544000516 sequence-specific DNA binding site [nucleotide binding]; other site 983544000517 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 983544000518 Domain of unknown function (DUF955); Region: DUF955; cl01076 983544000519 malate synthase A; Region: malate_syn_A; TIGR01344 983544000520 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 983544000521 active site 983544000522 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 983544000523 tetramer interface [polypeptide binding]; other site 983544000524 active site 983544000525 Mg2+/Mn2+ binding site [ion binding]; other site 983544000526 isocitrate lyase; Region: PLN02892 983544000527 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 983544000528 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 983544000529 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 983544000530 helicase 45; Provisional; Region: PTZ00424 983544000531 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 983544000532 ATP binding site [chemical binding]; other site 983544000533 Mg++ binding site [ion binding]; other site 983544000534 motif III; other site 983544000535 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983544000536 nucleotide binding region [chemical binding]; other site 983544000537 ATP-binding site [chemical binding]; other site 983544000538 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 983544000539 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544000540 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 983544000541 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983544000542 Zn2+ binding site [ion binding]; other site 983544000543 Mg2+ binding site [ion binding]; other site 983544000544 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 983544000545 synthetase active site [active] 983544000546 NTP binding site [chemical binding]; other site 983544000547 metal binding site [ion binding]; metal-binding site 983544000548 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 983544000549 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 983544000550 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 983544000551 metal binding site 2 [ion binding]; metal-binding site 983544000552 putative DNA binding helix; other site 983544000553 metal binding site 1 [ion binding]; metal-binding site 983544000554 dimer interface [polypeptide binding]; other site 983544000555 structural Zn2+ binding site [ion binding]; other site 983544000556 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 983544000557 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 983544000558 GDP-binding site [chemical binding]; other site 983544000559 ACT binding site; other site 983544000560 IMP binding site; other site 983544000561 OstA-like protein; Region: OstA_2; pfam13100 983544000562 OstA-like protein; Region: OstA; cl00844 983544000563 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 983544000564 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 983544000565 inhibitor-cofactor binding pocket; inhibition site 983544000566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544000567 catalytic residue [active] 983544000568 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544000569 binding surface 983544000570 TPR motif; other site 983544000571 TPR repeat; Region: TPR_11; pfam13414 983544000572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544000573 binding surface 983544000574 TPR motif; other site 983544000575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544000576 binding surface 983544000577 TPR motif; other site 983544000578 TPR repeat; Region: TPR_11; pfam13414 983544000579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544000580 binding surface 983544000581 TPR repeat; Region: TPR_11; pfam13414 983544000582 TPR motif; other site 983544000583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544000584 binding surface 983544000585 TPR motif; other site 983544000586 Domain of unknown function (DUF368); Region: DUF368; pfam04018 983544000587 Domain of unknown function (DUF368); Region: DUF368; pfam04018 983544000588 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 983544000589 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 983544000590 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 983544000591 shikimate binding site; other site 983544000592 NAD(P) binding site [chemical binding]; other site 983544000593 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 983544000594 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 983544000595 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 983544000596 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 983544000597 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 983544000598 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 983544000599 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 983544000600 homodimer interface [polypeptide binding]; other site 983544000601 metal binding site [ion binding]; metal-binding site 983544000602 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 983544000603 homodimer interface [polypeptide binding]; other site 983544000604 active site 983544000605 putative chemical substrate binding site [chemical binding]; other site 983544000606 metal binding site [ion binding]; metal-binding site 983544000607 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 983544000608 active site 983544000609 catalytic residues [active] 983544000610 metal binding site [ion binding]; metal-binding site 983544000611 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 983544000612 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 983544000613 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 983544000614 trimer interface [polypeptide binding]; other site 983544000615 active site 983544000616 substrate binding site [chemical binding]; other site 983544000617 CoA binding site [chemical binding]; other site 983544000618 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 983544000619 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 983544000620 putative active site [active] 983544000621 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 983544000622 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 983544000623 Substrate binding site; other site 983544000624 metal-binding site 983544000625 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 983544000626 putative metal binding site; other site 983544000627 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 983544000628 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 983544000629 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 983544000630 Substrate binding site; other site 983544000631 metal-binding site 983544000632 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 983544000633 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983544000634 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 983544000635 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 983544000636 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 983544000637 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 983544000638 active site 983544000639 NTP binding site [chemical binding]; other site 983544000640 metal binding triad [ion binding]; metal-binding site 983544000641 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 983544000642 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983544000643 Zn2+ binding site [ion binding]; other site 983544000644 Mg2+ binding site [ion binding]; other site 983544000645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983544000646 Coenzyme A binding pocket [chemical binding]; other site 983544000647 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 983544000648 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 983544000649 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 983544000650 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 983544000651 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 983544000652 Walker A/P-loop; other site 983544000653 ATP binding site [chemical binding]; other site 983544000654 Q-loop/lid; other site 983544000655 ABC transporter signature motif; other site 983544000656 Walker B; other site 983544000657 D-loop; other site 983544000658 H-loop/switch region; other site 983544000659 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 983544000660 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 983544000661 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 983544000662 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 983544000663 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 983544000664 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 983544000665 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 983544000666 excinuclease ABC subunit B; Provisional; Region: PRK05298 983544000667 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983544000668 ATP binding site [chemical binding]; other site 983544000669 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983544000670 nucleotide binding region [chemical binding]; other site 983544000671 ATP-binding site [chemical binding]; other site 983544000672 Ultra-violet resistance protein B; Region: UvrB; pfam12344 983544000673 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 983544000674 putative hydrophobic ligand binding site [chemical binding]; other site 983544000675 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 983544000676 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 983544000677 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 983544000678 CoA-ligase; Region: Ligase_CoA; pfam00549 983544000679 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 983544000680 diaminopimelate decarboxylase; Region: lysA; TIGR01048 983544000681 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 983544000682 active site 983544000683 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 983544000684 substrate binding site [chemical binding]; other site 983544000685 catalytic residues [active] 983544000686 dimer interface [polypeptide binding]; other site 983544000687 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544000688 PAS fold; Region: PAS_3; pfam08447 983544000689 putative active site [active] 983544000690 heme pocket [chemical binding]; other site 983544000691 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983544000692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544000693 ATP binding site [chemical binding]; other site 983544000694 Mg2+ binding site [ion binding]; other site 983544000695 G-X-G motif; other site 983544000696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544000697 Response regulator receiver domain; Region: Response_reg; pfam00072 983544000698 active site 983544000699 phosphorylation site [posttranslational modification] 983544000700 intermolecular recognition site; other site 983544000701 dimerization interface [polypeptide binding]; other site 983544000702 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 983544000703 dimer interface [polypeptide binding]; other site 983544000704 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983544000705 ligand binding site [chemical binding]; other site 983544000706 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 983544000707 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 983544000708 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 983544000709 PA/protease or protease-like domain interface [polypeptide binding]; other site 983544000710 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 983544000711 Peptidase family M28; Region: Peptidase_M28; pfam04389 983544000712 metal binding site [ion binding]; metal-binding site 983544000713 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 983544000714 Response regulator receiver domain; Region: Response_reg; pfam00072 983544000715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544000716 active site 983544000717 phosphorylation site [posttranslational modification] 983544000718 intermolecular recognition site; other site 983544000719 dimerization interface [polypeptide binding]; other site 983544000720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983544000721 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 983544000722 Walker A motif; other site 983544000723 ATP binding site [chemical binding]; other site 983544000724 Walker B motif; other site 983544000725 arginine finger; other site 983544000726 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983544000727 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 983544000728 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 983544000729 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 983544000730 Walker A/P-loop; other site 983544000731 ATP binding site [chemical binding]; other site 983544000732 Q-loop/lid; other site 983544000733 ABC transporter signature motif; other site 983544000734 Walker B; other site 983544000735 D-loop; other site 983544000736 H-loop/switch region; other site 983544000737 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 983544000738 chaperone protein DnaJ; Provisional; Region: PRK14289 983544000739 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 983544000740 HSP70 interaction site [polypeptide binding]; other site 983544000741 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 983544000742 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 983544000743 dimer interface [polypeptide binding]; other site 983544000744 GrpE; Region: GrpE; pfam01025 983544000745 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 983544000746 dimer interface [polypeptide binding]; other site 983544000747 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 983544000748 YceI-like domain; Region: YceI; pfam04264 983544000749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983544000750 TIGR01777 family protein; Region: yfcH 983544000751 NAD(P) binding site [chemical binding]; other site 983544000752 active site 983544000753 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 983544000754 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 983544000755 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 983544000756 homodimer interface [polypeptide binding]; other site 983544000757 substrate-cofactor binding pocket; other site 983544000758 catalytic residue [active] 983544000759 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 983544000760 metal binding site [ion binding]; metal-binding site 983544000761 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 983544000762 putative hydrophobic ligand binding site [chemical binding]; other site 983544000763 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 983544000764 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 983544000765 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 983544000766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983544000767 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983544000768 putative substrate translocation pore; other site 983544000769 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983544000770 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983544000771 active site 983544000772 metal binding site [ion binding]; metal-binding site 983544000773 Predicted acyl esterases [General function prediction only]; Region: COG2936 983544000774 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 983544000775 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 983544000776 DJ-1 family protein; Region: not_thiJ; TIGR01383 983544000777 conserved cys residue [active] 983544000778 RES domain; Region: RES; pfam08808 983544000779 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 983544000780 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 983544000781 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 983544000782 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544000783 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983544000784 DNA binding residues [nucleotide binding] 983544000785 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983544000786 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983544000787 dimerization interface [polypeptide binding]; other site 983544000788 putative Zn2+ binding site [ion binding]; other site 983544000789 putative DNA binding site [nucleotide binding]; other site 983544000790 AsnC family; Region: AsnC_trans_reg; pfam01037 983544000791 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 983544000792 B12 binding site [chemical binding]; other site 983544000793 cobalt ligand [ion binding]; other site 983544000794 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 983544000795 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 983544000796 Walker A; other site 983544000797 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 983544000798 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 983544000799 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 983544000800 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 983544000801 putative active site [active] 983544000802 putative substrate binding site [chemical binding]; other site 983544000803 putative cosubstrate binding site; other site 983544000804 catalytic site [active] 983544000805 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 983544000806 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 983544000807 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 983544000808 intersubunit interface [polypeptide binding]; other site 983544000809 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 983544000810 active site 983544000811 dimer interface [polypeptide binding]; other site 983544000812 peptide chain release factor 1; Validated; Region: prfA; PRK00591 983544000813 This domain is found in peptide chain release factors; Region: PCRF; smart00937 983544000814 RF-1 domain; Region: RF-1; pfam00472 983544000815 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 983544000816 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 983544000817 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 983544000818 dimerization interface [polypeptide binding]; other site 983544000819 ATP binding site [chemical binding]; other site 983544000820 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 983544000821 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 983544000822 Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; pfam10614 983544000823 Curli assembly protein CsgE; Region: CsgE; cl08115 983544000824 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 983544000825 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 983544000826 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 983544000827 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 983544000828 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 983544000829 glutamine synthetase; Region: PLN02284 983544000830 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 983544000831 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 983544000832 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 983544000833 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 983544000834 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 983544000835 Endonuclease I; Region: Endonuclease_1; pfam04231 983544000836 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544000837 Helix-turn-helix domain; Region: HTH_17; pfam12728 983544000838 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983544000839 metal-binding site [ion binding] 983544000840 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983544000841 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 983544000842 HlyD family secretion protein; Region: HlyD_3; pfam13437 983544000843 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 983544000844 Domain of unknown function (DUF305); Region: DUF305; cl17794 983544000845 Heavy-metal-associated domain; Region: HMA; pfam00403 983544000846 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 983544000847 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983544000848 metal-binding site [ion binding] 983544000849 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 983544000850 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 983544000851 Soluble P-type ATPase [General function prediction only]; Region: COG4087 983544000852 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 983544000853 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983544000854 Haem-binding domain; Region: Haem_bd; pfam14376 983544000855 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 983544000856 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 983544000857 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 983544000858 Multicopper oxidase; Region: Cu-oxidase; pfam00394 983544000859 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 983544000860 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 983544000861 Outer membrane efflux protein; Region: OEP; pfam02321 983544000862 Outer membrane efflux protein; Region: OEP; pfam02321 983544000863 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 983544000864 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 983544000865 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 983544000866 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 983544000867 Soluble P-type ATPase [General function prediction only]; Region: COG4087 983544000868 DNA topoisomerase I; Validated; Region: PRK05582 983544000869 MerT mercuric transport protein; Region: MerT; cl03578 983544000870 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983544000871 metal-binding site [ion binding] 983544000872 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 983544000873 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 983544000874 metal binding site 2 [ion binding]; metal-binding site 983544000875 putative DNA binding helix; other site 983544000876 metal binding site 1 [ion binding]; metal-binding site 983544000877 dimer interface [polypeptide binding]; other site 983544000878 structural Zn2+ binding site [ion binding]; other site 983544000879 Cation efflux family; Region: Cation_efflux; cl00316 983544000880 HlyD family secretion protein; Region: HlyD_2; pfam12700 983544000881 HlyD family secretion protein; Region: HlyD_3; pfam13437 983544000882 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 983544000883 Outer membrane efflux protein; Region: OEP; pfam02321 983544000884 Outer membrane efflux protein; Region: OEP; pfam02321 983544000885 Phage associated DNA primase [General function prediction only]; Region: COG3378 983544000886 Helix-turn-helix domain; Region: HTH_17; pfam12728 983544000887 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 983544000888 active site 983544000889 catalytic residues [active] 983544000890 DNA binding site [nucleotide binding] 983544000891 Int/Topo IB signature motif; other site 983544000892 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 983544000893 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 983544000894 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 983544000895 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 983544000896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544000897 S-adenosylmethionine binding site [chemical binding]; other site 983544000898 triosephosphate isomerase; Provisional; Region: PRK14567 983544000899 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 983544000900 substrate binding site [chemical binding]; other site 983544000901 dimer interface [polypeptide binding]; other site 983544000902 catalytic triad [active] 983544000903 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 983544000904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 983544000905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983544000906 dimer interface [polypeptide binding]; other site 983544000907 conserved gate region; other site 983544000908 putative PBP binding loops; other site 983544000909 ABC-ATPase subunit interface; other site 983544000910 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 983544000911 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 983544000912 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 983544000913 dihydropteroate synthase; Region: DHPS; TIGR01496 983544000914 substrate binding pocket [chemical binding]; other site 983544000915 dimer interface [polypeptide binding]; other site 983544000916 inhibitor binding site; inhibition site 983544000917 Uncharacterized conserved protein [Function unknown]; Region: COG1624 983544000918 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 983544000919 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 983544000920 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 983544000921 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 983544000922 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 983544000923 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 983544000924 Walker A/P-loop; other site 983544000925 ATP binding site [chemical binding]; other site 983544000926 Q-loop/lid; other site 983544000927 ABC transporter signature motif; other site 983544000928 Walker B; other site 983544000929 D-loop; other site 983544000930 H-loop/switch region; other site 983544000931 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 983544000932 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 983544000933 dimerization interface 3.5A [polypeptide binding]; other site 983544000934 active site 983544000935 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 983544000936 active site 983544000937 metal binding site [ion binding]; metal-binding site 983544000938 homotetramer interface [polypeptide binding]; other site 983544000939 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 983544000940 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 983544000941 transcription termination factor Rho; Provisional; Region: PRK12608 983544000942 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 983544000943 RNA binding site [nucleotide binding]; other site 983544000944 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 983544000945 multimer interface [polypeptide binding]; other site 983544000946 Walker A motif; other site 983544000947 ATP binding site [chemical binding]; other site 983544000948 Walker B motif; other site 983544000949 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 983544000950 prolyl-tRNA synthetase; Provisional; Region: PRK08661 983544000951 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 983544000952 dimer interface [polypeptide binding]; other site 983544000953 motif 1; other site 983544000954 active site 983544000955 motif 2; other site 983544000956 motif 3; other site 983544000957 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 983544000958 anticodon binding site; other site 983544000959 zinc-binding site [ion binding]; other site 983544000960 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 983544000961 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041 983544000962 heterodimerization interface [polypeptide binding]; other site 983544000963 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 983544000964 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 983544000965 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 983544000966 GTP cyclohydrolase I; Provisional; Region: PLN03044 983544000967 active site 983544000968 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 983544000969 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 983544000970 active site 983544000971 HIGH motif; other site 983544000972 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 983544000973 KMSKS motif; other site 983544000974 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 983544000975 tRNA binding surface [nucleotide binding]; other site 983544000976 anticodon binding site; other site 983544000977 Haemolytic domain; Region: Haemolytic; pfam01809 983544000978 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 983544000979 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 983544000980 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 983544000981 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 983544000982 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 983544000983 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 983544000984 Protein export membrane protein; Region: SecD_SecF; pfam02355 983544000985 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 983544000986 malate dehydrogenase; Reviewed; Region: PRK06223 983544000987 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 983544000988 dimer interface [polypeptide binding]; other site 983544000989 NAD(P) binding site [chemical binding]; other site 983544000990 tetramer (dimer of dimers) interface [polypeptide binding]; other site 983544000991 substrate binding site [chemical binding]; other site 983544000992 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 983544000993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544000994 ATP binding site [chemical binding]; other site 983544000995 Mg2+ binding site [ion binding]; other site 983544000996 G-X-G motif; other site 983544000997 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 983544000998 anchoring element; other site 983544000999 dimer interface [polypeptide binding]; other site 983544001000 ATP binding site [chemical binding]; other site 983544001001 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 983544001002 active site 983544001003 putative metal-binding site [ion binding]; other site 983544001004 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 983544001005 asparagine synthetase B; Provisional; Region: asnB; PRK09431 983544001006 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 983544001007 active site 983544001008 dimer interface [polypeptide binding]; other site 983544001009 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 983544001010 Ligand Binding Site [chemical binding]; other site 983544001011 Molecular Tunnel; other site 983544001012 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 983544001013 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 983544001014 AAA-like domain; Region: AAA_10; pfam12846 983544001015 Uncharacterized conserved protein [Function unknown]; Region: COG1284 983544001016 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 983544001017 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 983544001018 Cupin domain; Region: Cupin_2; pfam07883 983544001019 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 983544001020 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983544001021 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 983544001022 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983544001023 RNA binding surface [nucleotide binding]; other site 983544001024 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 983544001025 probable active site [active] 983544001026 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 983544001027 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983544001028 putative metal binding site [ion binding]; other site 983544001029 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 983544001030 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 983544001031 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 983544001032 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 983544001033 homodimer interface [polypeptide binding]; other site 983544001034 NADP binding site [chemical binding]; other site 983544001035 substrate binding site [chemical binding]; other site 983544001036 signal recognition particle protein; Provisional; Region: PRK10867 983544001037 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 983544001038 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 983544001039 P loop; other site 983544001040 GTP binding site [chemical binding]; other site 983544001041 Signal peptide binding domain; Region: SRP_SPB; pfam02978 983544001042 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 983544001043 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544001044 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983544001045 DNA binding residues [nucleotide binding] 983544001046 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 983544001047 FecR protein; Region: FecR; pfam04773 983544001048 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 983544001049 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 983544001050 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 983544001051 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983544001052 Amidinotransferase; Region: Amidinotransf; cl12043 983544001053 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 983544001054 dimer interface [polypeptide binding]; other site 983544001055 Citrate synthase; Region: Citrate_synt; pfam00285 983544001056 active site 983544001057 citrylCoA binding site [chemical binding]; other site 983544001058 NADH binding [chemical binding]; other site 983544001059 cationic pore residues; other site 983544001060 oxalacetate/citrate binding site [chemical binding]; other site 983544001061 coenzyme A binding site [chemical binding]; other site 983544001062 catalytic triad [active] 983544001063 enolase; Provisional; Region: eno; PRK00077 983544001064 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 983544001065 dimer interface [polypeptide binding]; other site 983544001066 metal binding site [ion binding]; metal-binding site 983544001067 substrate binding pocket [chemical binding]; other site 983544001068 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 983544001069 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 983544001070 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 983544001071 catalytic site [active] 983544001072 subunit interface [polypeptide binding]; other site 983544001073 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 983544001074 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 983544001075 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 983544001076 alphaNTD homodimer interface [polypeptide binding]; other site 983544001077 alphaNTD - beta interaction site [polypeptide binding]; other site 983544001078 alphaNTD - beta' interaction site [polypeptide binding]; other site 983544001079 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 983544001080 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 983544001081 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 983544001082 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983544001083 RNA binding surface [nucleotide binding]; other site 983544001084 30S ribosomal protein S11; Validated; Region: PRK05309 983544001085 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 983544001086 30S ribosomal protein S13; Region: bact_S13; TIGR03631 983544001087 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 983544001088 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 983544001089 rRNA binding site [nucleotide binding]; other site 983544001090 predicted 30S ribosome binding site; other site 983544001091 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 983544001092 SecY translocase; Region: SecY; pfam00344 983544001093 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 983544001094 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 983544001095 23S rRNA binding site [nucleotide binding]; other site 983544001096 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 983544001097 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 983544001098 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 983544001099 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 983544001100 23S rRNA interface [nucleotide binding]; other site 983544001101 L21e interface [polypeptide binding]; other site 983544001102 5S rRNA interface [nucleotide binding]; other site 983544001103 L27 interface [polypeptide binding]; other site 983544001104 L5 interface [polypeptide binding]; other site 983544001105 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 983544001106 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 983544001107 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 983544001108 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 983544001109 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 983544001110 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 983544001111 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 983544001112 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 983544001113 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 983544001114 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 983544001115 RNA binding site [nucleotide binding]; other site 983544001116 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 983544001117 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 983544001118 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 983544001119 23S rRNA interface [nucleotide binding]; other site 983544001120 putative translocon interaction site; other site 983544001121 signal recognition particle (SRP54) interaction site; other site 983544001122 L23 interface [polypeptide binding]; other site 983544001123 trigger factor interaction site; other site 983544001124 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 983544001125 23S rRNA interface [nucleotide binding]; other site 983544001126 5S rRNA interface [nucleotide binding]; other site 983544001127 putative antibiotic binding site [chemical binding]; other site 983544001128 L25 interface [polypeptide binding]; other site 983544001129 L27 interface [polypeptide binding]; other site 983544001130 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 983544001131 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 983544001132 G-X-X-G motif; other site 983544001133 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 983544001134 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 983544001135 putative translocon binding site; other site 983544001136 protein-rRNA interface [nucleotide binding]; other site 983544001137 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 983544001138 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 983544001139 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 983544001140 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 983544001141 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 983544001142 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 983544001143 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 983544001144 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 983544001145 elongation factor G; Reviewed; Region: PRK12739 983544001146 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 983544001147 G1 box; other site 983544001148 putative GEF interaction site [polypeptide binding]; other site 983544001149 GTP/Mg2+ binding site [chemical binding]; other site 983544001150 Switch I region; other site 983544001151 G2 box; other site 983544001152 G3 box; other site 983544001153 Switch II region; other site 983544001154 G4 box; other site 983544001155 G5 box; other site 983544001156 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 983544001157 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 983544001158 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 983544001159 30S ribosomal protein S7; Validated; Region: PRK05302 983544001160 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 983544001161 S17 interaction site [polypeptide binding]; other site 983544001162 S8 interaction site; other site 983544001163 16S rRNA interaction site [nucleotide binding]; other site 983544001164 streptomycin interaction site [chemical binding]; other site 983544001165 23S rRNA interaction site [nucleotide binding]; other site 983544001166 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 983544001167 Surface antigen; Region: Bac_surface_Ag; pfam01103 983544001168 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 983544001169 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544001170 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 983544001171 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 983544001172 starch binding outer membrane protein SusD; Region: SusD; cl17845 983544001173 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 983544001174 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544001175 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 983544001176 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544001177 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 983544001178 SusD family; Region: SusD; pfam07980 983544001179 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 983544001180 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 983544001181 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 983544001182 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 983544001183 recombination factor protein RarA; Reviewed; Region: PRK13342 983544001184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983544001185 Walker A motif; other site 983544001186 ATP binding site [chemical binding]; other site 983544001187 Walker B motif; other site 983544001188 arginine finger; other site 983544001189 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 983544001190 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 983544001191 active site 983544001192 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544001193 dUMP phosphatase; Provisional; Region: PRK09449 983544001194 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983544001195 motif II; other site 983544001196 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 983544001197 putative active site [active] 983544001198 hypothetical protein; Reviewed; Region: PRK00024 983544001199 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 983544001200 MPN+ (JAMM) motif; other site 983544001201 Zinc-binding site [ion binding]; other site 983544001202 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 983544001203 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 983544001204 gliding motility-associated protein GldC; Region: GldC; TIGR03515 983544001205 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 983544001206 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 983544001207 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 983544001208 homodimer interface [polypeptide binding]; other site 983544001209 NAD binding pocket [chemical binding]; other site 983544001210 ATP binding pocket [chemical binding]; other site 983544001211 Mg binding site [ion binding]; other site 983544001212 active-site loop [active] 983544001213 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983544001214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544001215 active site 983544001216 phosphorylation site [posttranslational modification] 983544001217 intermolecular recognition site; other site 983544001218 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983544001219 DNA binding residues [nucleotide binding] 983544001220 dimerization interface [polypeptide binding]; other site 983544001221 DNA primase; Validated; Region: dnaG; PRK05667 983544001222 CHC2 zinc finger; Region: zf-CHC2; cl17510 983544001223 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 983544001224 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 983544001225 active site 983544001226 metal binding site [ion binding]; metal-binding site 983544001227 interdomain interaction site; other site 983544001228 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 983544001229 Double zinc ribbon; Region: DZR; pfam12773 983544001230 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 983544001231 putative catalytic residues [active] 983544001232 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 983544001233 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 983544001234 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 983544001235 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544001236 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983544001237 DNA binding residues [nucleotide binding] 983544001238 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 983544001239 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 983544001240 substrate binding pocket [chemical binding]; other site 983544001241 chain length determination region; other site 983544001242 substrate-Mg2+ binding site; other site 983544001243 catalytic residues [active] 983544001244 aspartate-rich region 1; other site 983544001245 active site lid residues [active] 983544001246 aspartate-rich region 2; other site 983544001247 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544001248 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 983544001249 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983544001250 FeS/SAM binding site; other site 983544001251 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 983544001252 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 983544001253 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 983544001254 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 983544001255 hinge; other site 983544001256 active site 983544001257 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 983544001258 homodimer interface [polypeptide binding]; other site 983544001259 metal binding site [ion binding]; metal-binding site 983544001260 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 983544001261 putative active site [active] 983544001262 dimerization interface [polypeptide binding]; other site 983544001263 putative tRNAtyr binding site [nucleotide binding]; other site 983544001264 GTPase RsgA; Reviewed; Region: PRK00098 983544001265 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 983544001266 RNA binding site [nucleotide binding]; other site 983544001267 homodimer interface [polypeptide binding]; other site 983544001268 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 983544001269 GTPase/Zn-binding domain interface [polypeptide binding]; other site 983544001270 GTP/Mg2+ binding site [chemical binding]; other site 983544001271 G4 box; other site 983544001272 G5 box; other site 983544001273 G1 box; other site 983544001274 Switch I region; other site 983544001275 G2 box; other site 983544001276 G3 box; other site 983544001277 Switch II region; other site 983544001278 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 983544001279 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 983544001280 Chorismate mutase type II; Region: CM_2; smart00830 983544001281 prephenate dehydrogenase; Validated; Region: PRK08507 983544001282 Prephenate dehydrogenase; Region: PDH; pfam02153 983544001283 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 983544001284 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983544001285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544001286 homodimer interface [polypeptide binding]; other site 983544001287 catalytic residue [active] 983544001288 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 983544001289 Prephenate dehydratase; Region: PDT; pfam00800 983544001290 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 983544001291 putative L-Phe binding site [chemical binding]; other site 983544001292 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 983544001293 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 983544001294 Walker A/P-loop; other site 983544001295 ATP binding site [chemical binding]; other site 983544001296 Q-loop/lid; other site 983544001297 ABC transporter signature motif; other site 983544001298 Walker B; other site 983544001299 D-loop; other site 983544001300 H-loop/switch region; other site 983544001301 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 983544001302 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 983544001303 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 983544001304 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 983544001305 CysD dimerization site [polypeptide binding]; other site 983544001306 G1 box; other site 983544001307 putative GEF interaction site [polypeptide binding]; other site 983544001308 GTP/Mg2+ binding site [chemical binding]; other site 983544001309 Switch I region; other site 983544001310 G2 box; other site 983544001311 G3 box; other site 983544001312 Switch II region; other site 983544001313 G4 box; other site 983544001314 G5 box; other site 983544001315 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 983544001316 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 983544001317 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 983544001318 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 983544001319 Active Sites [active] 983544001320 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 983544001321 Active Sites [active] 983544001322 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 983544001323 Rrf2 family protein; Region: rrf2_super; TIGR00738 983544001324 Transcriptional regulator; Region: Rrf2; pfam02082 983544001325 S-adenosylmethionine synthetase; Validated; Region: PRK05250 983544001326 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 983544001327 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 983544001328 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 983544001329 tRNA-specific 2-thiouridylase MnmA; Reviewed; Region: mnmA; PRK00143 983544001330 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 983544001331 Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903 983544001332 Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903 983544001333 GLPGLI family protein; Region: GLPGLI; TIGR01200 983544001334 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983544001335 dimer interface [polypeptide binding]; other site 983544001336 phosphorylation site [posttranslational modification] 983544001337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544001338 ATP binding site [chemical binding]; other site 983544001339 Mg2+ binding site [ion binding]; other site 983544001340 G-X-G motif; other site 983544001341 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983544001342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544001343 active site 983544001344 phosphorylation site [posttranslational modification] 983544001345 intermolecular recognition site; other site 983544001346 dimerization interface [polypeptide binding]; other site 983544001347 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983544001348 DNA binding site [nucleotide binding] 983544001349 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983544001350 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983544001351 dimer interface [polypeptide binding]; other site 983544001352 phosphorylation site [posttranslational modification] 983544001353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544001354 ATP binding site [chemical binding]; other site 983544001355 Mg2+ binding site [ion binding]; other site 983544001356 G-X-G motif; other site 983544001357 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983544001358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544001359 active site 983544001360 phosphorylation site [posttranslational modification] 983544001361 intermolecular recognition site; other site 983544001362 dimerization interface [polypeptide binding]; other site 983544001363 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983544001364 DNA binding site [nucleotide binding] 983544001365 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 983544001366 Interdomain contacts; other site 983544001367 Cytokine receptor motif; other site 983544001368 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544001369 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544001370 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 983544001371 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 983544001372 Substrate-binding site [chemical binding]; other site 983544001373 Substrate specificity [chemical binding]; other site 983544001374 polyphosphate kinase; Provisional; Region: PRK05443 983544001375 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 983544001376 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 983544001377 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 983544001378 domain interface [polypeptide binding]; other site 983544001379 active site 983544001380 catalytic site [active] 983544001381 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 983544001382 domain interface [polypeptide binding]; other site 983544001383 active site 983544001384 catalytic site [active] 983544001385 Uncharacterized conserved protein [Function unknown]; Region: COG4850 983544001386 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 983544001387 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 983544001388 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 983544001389 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 983544001390 Zn binding site [ion binding]; other site 983544001391 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544001392 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544001393 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 983544001394 active site pocket [active] 983544001395 oxyanion hole [active] 983544001396 catalytic triad [active] 983544001397 active site nucleophile [active] 983544001398 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 983544001399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983544001400 Coenzyme A binding pocket [chemical binding]; other site 983544001401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983544001402 Coenzyme A binding pocket [chemical binding]; other site 983544001403 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 983544001404 Peptidase family M48; Region: Peptidase_M48; pfam01435 983544001405 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 983544001406 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 983544001407 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 983544001408 phosphoglyceromutase; Provisional; Region: PRK05434 983544001409 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 983544001410 active site 983544001411 motif I; other site 983544001412 motif II; other site 983544001413 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 983544001414 active site 983544001415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544001416 Protein of unknown function (DUF423); Region: DUF423; pfam04241 983544001417 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 983544001418 ApbE family; Region: ApbE; pfam02424 983544001419 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 983544001420 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983544001421 catalytic loop [active] 983544001422 iron binding site [ion binding]; other site 983544001423 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 983544001424 FAD binding pocket [chemical binding]; other site 983544001425 FAD binding motif [chemical binding]; other site 983544001426 phosphate binding motif [ion binding]; other site 983544001427 beta-alpha-beta structure motif; other site 983544001428 NAD binding pocket [chemical binding]; other site 983544001429 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 983544001430 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 983544001431 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 983544001432 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 983544001433 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 983544001434 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 983544001435 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 983544001436 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 983544001437 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 983544001438 NRDE protein; Region: NRDE; cl01315 983544001439 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 983544001440 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 983544001441 Glutamate binding site [chemical binding]; other site 983544001442 NAD binding site [chemical binding]; other site 983544001443 catalytic residues [active] 983544001444 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 983544001445 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 983544001446 Fatty acid desaturase; Region: FA_desaturase; pfam00487 983544001447 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 983544001448 putative di-iron ligands [ion binding]; other site 983544001449 aspartate aminotransferase; Provisional; Region: PRK05764 983544001450 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983544001451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544001452 homodimer interface [polypeptide binding]; other site 983544001453 catalytic residue [active] 983544001454 Cation transport protein; Region: TrkH; cl17365 983544001455 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 983544001456 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 983544001457 TrkA-N domain; Region: TrkA_N; pfam02254 983544001458 TrkA-C domain; Region: TrkA_C; pfam02080 983544001459 TrkA-N domain; Region: TrkA_N; pfam02254 983544001460 TrkA-C domain; Region: TrkA_C; pfam02080 983544001461 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 983544001462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544001463 S-adenosylmethionine binding site [chemical binding]; other site 983544001464 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 983544001465 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 983544001466 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 983544001467 Surface antigen; Region: Bac_surface_Ag; pfam01103 983544001468 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 983544001469 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 983544001470 active site 983544001471 intersubunit interface [polypeptide binding]; other site 983544001472 zinc binding site [ion binding]; other site 983544001473 Na+ binding site [ion binding]; other site 983544001474 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 983544001475 active site 983544001476 catalytic residues [active] 983544001477 metal binding site [ion binding]; metal-binding site 983544001478 CheB methylesterase; Region: CheB_methylest; pfam01339 983544001479 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 983544001480 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 983544001481 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 983544001482 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 983544001483 PAS domain; Region: PAS_10; pfam13596 983544001484 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 983544001485 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983544001486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983544001487 dimer interface [polypeptide binding]; other site 983544001488 phosphorylation site [posttranslational modification] 983544001489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544001490 ATP binding site [chemical binding]; other site 983544001491 Mg2+ binding site [ion binding]; other site 983544001492 G-X-G motif; other site 983544001493 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983544001494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544001495 active site 983544001496 phosphorylation site [posttranslational modification] 983544001497 intermolecular recognition site; other site 983544001498 dimerization interface [polypeptide binding]; other site 983544001499 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 983544001500 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 983544001501 PAS domain S-box; Region: sensory_box; TIGR00229 983544001502 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544001503 putative active site [active] 983544001504 heme pocket [chemical binding]; other site 983544001505 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983544001506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544001507 ATP binding site [chemical binding]; other site 983544001508 Mg2+ binding site [ion binding]; other site 983544001509 G-X-G motif; other site 983544001510 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 983544001511 16S/18S rRNA binding site [nucleotide binding]; other site 983544001512 S13e-L30e interaction site [polypeptide binding]; other site 983544001513 25S rRNA binding site [nucleotide binding]; other site 983544001514 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 983544001515 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 983544001516 RNase E interface [polypeptide binding]; other site 983544001517 trimer interface [polypeptide binding]; other site 983544001518 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 983544001519 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 983544001520 RNase E interface [polypeptide binding]; other site 983544001521 trimer interface [polypeptide binding]; other site 983544001522 active site 983544001523 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 983544001524 putative nucleic acid binding region [nucleotide binding]; other site 983544001525 G-X-X-G motif; other site 983544001526 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 983544001527 RNA binding site [nucleotide binding]; other site 983544001528 domain interface; other site 983544001529 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 983544001530 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 983544001531 DXD motif; other site 983544001532 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 983544001533 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544001534 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983544001535 DNA binding residues [nucleotide binding] 983544001536 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 983544001537 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 983544001538 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 983544001539 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 983544001540 nucleotide binding site [chemical binding]; other site 983544001541 homotetrameric interface [polypeptide binding]; other site 983544001542 putative phosphate binding site [ion binding]; other site 983544001543 putative allosteric binding site; other site 983544001544 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 983544001545 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 983544001546 putative catalytic cysteine [active] 983544001547 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 983544001548 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 983544001549 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544001550 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 983544001551 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983544001552 DNA binding residues [nucleotide binding] 983544001553 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 983544001554 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 983544001555 substrate binding site [chemical binding]; other site 983544001556 hexamer interface [polypeptide binding]; other site 983544001557 metal binding site [ion binding]; metal-binding site 983544001558 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 983544001559 Yqey-like protein; Region: YqeY; pfam09424 983544001560 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 983544001561 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 983544001562 nucleotide binding site [chemical binding]; other site 983544001563 SulA interaction site; other site 983544001564 cell division protein FtsA; Region: ftsA; TIGR01174 983544001565 Cell division protein FtsA; Region: FtsA; smart00842 983544001566 Cell division protein FtsA; Region: FtsA; pfam14450 983544001567 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 983544001568 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 983544001569 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983544001570 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983544001571 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 983544001572 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 983544001573 active site 983544001574 homodimer interface [polypeptide binding]; other site 983544001575 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 983544001576 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 983544001577 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 983544001578 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983544001579 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983544001580 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 983544001581 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 983544001582 Mg++ binding site [ion binding]; other site 983544001583 putative catalytic motif [active] 983544001584 putative substrate binding site [chemical binding]; other site 983544001585 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 983544001586 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 983544001587 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 983544001588 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983544001589 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 983544001590 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 983544001591 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 983544001592 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 983544001593 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 983544001594 MraW methylase family; Region: Methyltransf_5; cl17771 983544001595 cell division protein MraZ; Reviewed; Region: PRK00326 983544001596 MraZ protein; Region: MraZ; pfam02381 983544001597 MraZ protein; Region: MraZ; pfam02381 983544001598 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983544001599 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 983544001600 G1 box; other site 983544001601 GTP/Mg2+ binding site [chemical binding]; other site 983544001602 Switch I region; other site 983544001603 G2 box; other site 983544001604 G3 box; other site 983544001605 Switch II region; other site 983544001606 G4 box; other site 983544001607 G5 box; other site 983544001608 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 983544001609 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 983544001610 active site 983544001611 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 983544001612 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 983544001613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983544001614 dimer interface [polypeptide binding]; other site 983544001615 conserved gate region; other site 983544001616 putative PBP binding loops; other site 983544001617 ABC-ATPase subunit interface; other site 983544001618 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 983544001619 C-terminal peptidase (prc); Region: prc; TIGR00225 983544001620 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 983544001621 protein binding site [polypeptide binding]; other site 983544001622 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 983544001623 Catalytic dyad [active] 983544001624 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 983544001625 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 983544001626 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 983544001627 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 983544001628 NlpC/P60 family; Region: NLPC_P60; pfam00877 983544001629 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 983544001630 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 983544001631 Competence protein; Region: Competence; pfam03772 983544001632 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 983544001633 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 983544001634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983544001635 putative substrate translocation pore; other site 983544001636 POT family; Region: PTR2; cl17359 983544001637 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 983544001638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983544001639 putative substrate translocation pore; other site 983544001640 POT family; Region: PTR2; cl17359 983544001641 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 983544001642 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 983544001643 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 983544001644 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 983544001645 homodimer interface [polypeptide binding]; other site 983544001646 catalytic residues [active] 983544001647 NAD binding site [chemical binding]; other site 983544001648 substrate binding pocket [chemical binding]; other site 983544001649 flexible flap; other site 983544001650 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 983544001651 SurA N-terminal domain; Region: SurA_N_3; cl07813 983544001652 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 983544001653 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 983544001654 Domain of unknown function DUF21; Region: DUF21; pfam01595 983544001655 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 983544001656 Transporter associated domain; Region: CorC_HlyC; smart01091 983544001657 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 983544001658 TPR repeat; Region: TPR_11; pfam13414 983544001659 pantothenate kinase; Reviewed; Region: PRK13320 983544001660 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 983544001661 Transposase; Region: HTH_Tnp_1; cl17663 983544001662 putative transposase OrfB; Reviewed; Region: PHA02517 983544001663 Integrase core domain; Region: rve; pfam00665 983544001664 Integrase core domain; Region: rve_3; pfam13683 983544001665 Beta-lactamase; Region: Beta-lactamase; pfam00144 983544001666 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 983544001667 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544001668 TPR repeat; Region: TPR_11; pfam13414 983544001669 binding surface 983544001670 TPR motif; other site 983544001671 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 983544001672 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983544001673 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983544001674 Amidohydrolase; Region: Amidohydro_4; pfam13147 983544001675 active site 983544001676 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 983544001677 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 983544001678 OsmC-like protein; Region: OsmC; pfam02566 983544001679 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 983544001680 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 983544001681 homodimer interface [polypeptide binding]; other site 983544001682 substrate-cofactor binding pocket; other site 983544001683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544001684 catalytic residue [active] 983544001685 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 983544001686 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 983544001687 active site 983544001688 catalytic residues [active] 983544001689 metal binding site [ion binding]; metal-binding site 983544001690 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 983544001691 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 983544001692 substrate binding site [chemical binding]; other site 983544001693 ligand binding site [chemical binding]; other site 983544001694 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 983544001695 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 983544001696 hypothetical protein; Provisional; Region: PRK14812 983544001697 substrate binding site [chemical binding]; other site 983544001698 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 983544001699 tartrate dehydrogenase; Region: TTC; TIGR02089 983544001700 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 983544001701 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 983544001702 Nitrogen regulatory protein P-II; Region: P-II; smart00938 983544001703 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 983544001704 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 983544001705 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 983544001706 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 983544001707 active site 983544001708 dimer interface [polypeptide binding]; other site 983544001709 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 983544001710 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 983544001711 active site 983544001712 FMN binding site [chemical binding]; other site 983544001713 substrate binding site [chemical binding]; other site 983544001714 3Fe-4S cluster binding site [ion binding]; other site 983544001715 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 983544001716 domain interface; other site 983544001717 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 983544001718 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 983544001719 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 983544001720 argininosuccinate lyase; Provisional; Region: PRK00855 983544001721 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 983544001722 active sites [active] 983544001723 tetramer interface [polypeptide binding]; other site 983544001724 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 983544001725 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 983544001726 metal binding site [ion binding]; metal-binding site 983544001727 dimer interface [polypeptide binding]; other site 983544001728 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 983544001729 nucleotide binding site [chemical binding]; other site 983544001730 N-acetyl-L-glutamate binding site [chemical binding]; other site 983544001731 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 983544001732 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 983544001733 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 983544001734 acetylornithine aminotransferase; Provisional; Region: PRK02627 983544001735 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 983544001736 inhibitor-cofactor binding pocket; inhibition site 983544001737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544001738 catalytic residue [active] 983544001739 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 983544001740 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 983544001741 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 983544001742 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 983544001743 argininosuccinate synthase; Provisional; Region: PRK13820 983544001744 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 983544001745 Ligand Binding Site [chemical binding]; other site 983544001746 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 983544001747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983544001748 Coenzyme A binding pocket [chemical binding]; other site 983544001749 threonine dehydratase; Validated; Region: PRK08639 983544001750 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 983544001751 tetramer interface [polypeptide binding]; other site 983544001752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544001753 catalytic residue [active] 983544001754 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 983544001755 ketol-acid reductoisomerase; Validated; Region: PRK05225 983544001756 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 983544001757 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 983544001758 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 983544001759 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 983544001760 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 983544001761 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 983544001762 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 983544001763 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 983544001764 PYR/PP interface [polypeptide binding]; other site 983544001765 dimer interface [polypeptide binding]; other site 983544001766 TPP binding site [chemical binding]; other site 983544001767 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 983544001768 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 983544001769 TPP-binding site [chemical binding]; other site 983544001770 dimer interface [polypeptide binding]; other site 983544001771 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 983544001772 Family of unknown function (DUF490); Region: DUF490; pfam04357 983544001773 Surface antigen; Region: Bac_surface_Ag; pfam01103 983544001774 Protein of unknown function (DUF2452); Region: DUF2452; pfam10504 983544001775 alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169 983544001776 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 983544001777 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983544001778 FeS/SAM binding site; other site 983544001779 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 983544001780 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; pfam09837 983544001781 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 983544001782 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544001783 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 983544001784 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544001785 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 983544001786 starch binding outer membrane protein SusD; Region: SusD; cd08977 983544001787 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 983544001788 Na binding site [ion binding]; other site 983544001789 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 983544001790 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 983544001791 active site residue [active] 983544001792 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 983544001793 purine nucleoside phosphorylase; Provisional; Region: PRK08202 983544001794 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 983544001795 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 983544001796 Protein of unknown function, DUF547; Region: DUF547; pfam04784 983544001797 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 983544001798 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 983544001799 Probable Catalytic site; other site 983544001800 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 983544001801 active site 983544001802 metal binding site [ion binding]; metal-binding site 983544001803 Surface antigen; Region: Bac_surface_Ag; pfam01103 983544001804 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 983544001805 Protein of unknown function, DUF547; Region: DUF547; pfam04784 983544001806 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 983544001807 4Fe-4S binding domain; Region: Fer4_5; pfam12801 983544001808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 983544001809 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 983544001810 Ligand binding site; other site 983544001811 DXD motif; other site 983544001812 Putative Catalytic site; other site 983544001813 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 983544001814 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 983544001815 DXD motif; other site 983544001816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 983544001817 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 983544001818 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 983544001819 deoxyhypusine synthase; Region: dhys; TIGR00321 983544001820 Deoxyhypusine synthase; Region: DS; cl00826 983544001821 Deoxyhypusine synthase; Region: DS; cl00826 983544001822 agmatinase; Region: agmatinase; TIGR01230 983544001823 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 983544001824 putative active site [active] 983544001825 Mn binding site [ion binding]; other site 983544001826 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 983544001827 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 983544001828 dimer interface [polypeptide binding]; other site 983544001829 active site 983544001830 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 983544001831 catalytic residues [active] 983544001832 substrate binding site [chemical binding]; other site 983544001833 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 983544001834 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 983544001835 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983544001836 RNA binding surface [nucleotide binding]; other site 983544001837 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 983544001838 active site 983544001839 Predicted amidohydrolase [General function prediction only]; Region: COG0388 983544001840 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 983544001841 putative active site [active] 983544001842 catalytic triad [active] 983544001843 putative dimer interface [polypeptide binding]; other site 983544001844 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 983544001845 UbiA prenyltransferase family; Region: UbiA; pfam01040 983544001846 mevalonate kinase; Region: mevalon_kin; TIGR00549 983544001847 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 983544001848 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 983544001849 diphosphomevalonate decarboxylase; Region: PLN02407 983544001850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983544001851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983544001852 flavoprotein, HI0933 family; Region: TIGR00275 983544001853 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 983544001854 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 983544001855 active site 983544001856 catalytic site [active] 983544001857 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 983544001858 active site 983544001859 metal binding site [ion binding]; metal-binding site 983544001860 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 983544001861 Surface antigen; Region: Bac_surface_Ag; pfam01103 983544001862 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983544001863 Zn2+ binding site [ion binding]; other site 983544001864 Mg2+ binding site [ion binding]; other site 983544001865 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 983544001866 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 983544001867 active site 983544001868 catalytic site [active] 983544001869 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 983544001870 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 983544001871 active site 983544001872 catalytic site [active] 983544001873 Putative esterase; Region: Esterase; pfam00756 983544001874 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 983544001875 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 983544001876 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 983544001877 CtsZ (cyclic tetrasaccharide-synthesizing enzyme Z) is a bacterial 6-alpha-glucosyltransferase, first identified in Arthrobacter globiformis, that produces cyclic tetrasaccharides together with a closely related enzyme CtsY. CtsZ and CtsY both have a...; Region: GH31_transferase_CtsZ; cd06598 983544001878 putative active site [active] 983544001879 putative catalytic site [active] 983544001880 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 983544001881 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 983544001882 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 983544001883 Ca binding site [ion binding]; other site 983544001884 active site 983544001885 homodimer interface [polypeptide binding]; other site 983544001886 catalytic site [active] 983544001887 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 983544001888 maltose phosphorylase; Provisional; Region: PRK13807 983544001889 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 983544001890 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 983544001891 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 983544001892 beta-phosphoglucomutase; Region: bPGM; TIGR01990 983544001893 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983544001894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983544001895 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983544001896 putative substrate translocation pore; other site 983544001897 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983544001898 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983544001899 DNA binding site [nucleotide binding] 983544001900 domain linker motif; other site 983544001901 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 983544001902 dimerization interface [polypeptide binding]; other site 983544001903 ligand binding site [chemical binding]; other site 983544001904 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 983544001905 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544001906 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 983544001907 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544001908 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 983544001909 starch binding outer membrane protein SusD; Region: SusD; cd08977 983544001910 SusE outer membrane protein; Region: SusE; pfam14292 983544001911 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 983544001912 starch binding site [chemical binding]; other site 983544001913 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 983544001914 starch binding site [chemical binding]; other site 983544001915 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 983544001916 starch binding site [chemical binding]; other site 983544001917 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 983544001918 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 983544001919 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 983544001920 active site 983544001921 catalytic site [active] 983544001922 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544001923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983544001924 Predicted permeases [General function prediction only]; Region: COG0730 983544001925 ABC-2 type transporter; Region: ABC2_membrane; cl17235 983544001926 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 983544001927 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 983544001928 NodB motif; other site 983544001929 active site 983544001930 catalytic site [active] 983544001931 metal binding site [ion binding]; metal-binding site 983544001932 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 983544001933 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 983544001934 catalytic residues [active] 983544001935 phosphodiesterase YaeI; Provisional; Region: PRK11340 983544001936 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 983544001937 putative active site [active] 983544001938 putative metal binding site [ion binding]; other site 983544001939 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 983544001940 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 983544001941 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 983544001942 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 983544001943 L-fucose transporter; Provisional; Region: PRK10133; cl17665 983544001944 L-fucose transporter; Provisional; Region: PRK10133; cl17665 983544001945 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 983544001946 active site 983544001947 dimer interface [polypeptide binding]; other site 983544001948 catalytic nucleophile [active] 983544001949 DNA polymerase I; Region: pola; TIGR00593 983544001950 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 983544001951 active site 983544001952 metal binding site 1 [ion binding]; metal-binding site 983544001953 putative 5' ssDNA interaction site; other site 983544001954 metal binding site 3; metal-binding site 983544001955 metal binding site 2 [ion binding]; metal-binding site 983544001956 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 983544001957 putative DNA binding site [nucleotide binding]; other site 983544001958 putative metal binding site [ion binding]; other site 983544001959 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 983544001960 active site 983544001961 catalytic site [active] 983544001962 substrate binding site [chemical binding]; other site 983544001963 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 983544001964 active site 983544001965 DNA binding site [nucleotide binding] 983544001966 catalytic site [active] 983544001967 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 983544001968 active site 983544001969 8-oxo-dGMP binding site [chemical binding]; other site 983544001970 nudix motif; other site 983544001971 metal binding site [ion binding]; metal-binding site 983544001972 PLD-like domain; Region: PLDc_2; pfam13091 983544001973 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 983544001974 putative homodimer interface [polypeptide binding]; other site 983544001975 putative active site [active] 983544001976 catalytic site [active] 983544001977 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 983544001978 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983544001979 ATP binding site [chemical binding]; other site 983544001980 putative Mg++ binding site [ion binding]; other site 983544001981 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983544001982 nucleotide binding region [chemical binding]; other site 983544001983 ATP-binding site [chemical binding]; other site 983544001984 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 983544001985 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 983544001986 hypothetical protein; Provisional; Region: PRK00955 983544001987 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 983544001988 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 983544001989 23S rRNA interface [nucleotide binding]; other site 983544001990 L3 interface [polypeptide binding]; other site 983544001991 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 983544001992 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 983544001993 rRNA interaction site [nucleotide binding]; other site 983544001994 S8 interaction site; other site 983544001995 putative laminin-1 binding site; other site 983544001996 elongation factor Ts; Provisional; Region: tsf; PRK09377 983544001997 UBA/TS-N domain; Region: UBA; pfam00627 983544001998 Elongation factor TS; Region: EF_TS; pfam00889 983544001999 Elongation factor TS; Region: EF_TS; pfam00889 983544002000 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 983544002001 putative nucleotide binding site [chemical binding]; other site 983544002002 uridine monophosphate binding site [chemical binding]; other site 983544002003 homohexameric interface [polypeptide binding]; other site 983544002004 ribosome recycling factor; Reviewed; Region: frr; PRK00083 983544002005 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 983544002006 hinge region; other site 983544002007 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 983544002008 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 983544002009 catalytic residues [active] 983544002010 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 983544002011 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 983544002012 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 983544002013 putative dimer interface [polypeptide binding]; other site 983544002014 putative anticodon binding site; other site 983544002015 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 983544002016 homodimer interface [polypeptide binding]; other site 983544002017 motif 1; other site 983544002018 motif 2; other site 983544002019 active site 983544002020 motif 3; other site 983544002021 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 983544002022 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 983544002023 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 983544002024 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 983544002025 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 983544002026 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 983544002027 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 983544002028 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 983544002029 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 983544002030 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 983544002031 active site 983544002032 homodimer interface [polypeptide binding]; other site 983544002033 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 983544002034 active site 983544002035 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983544002036 CHAT domain; Region: CHAT; pfam12770 983544002037 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 983544002038 catalytic motif [active] 983544002039 Catalytic residue [active] 983544002040 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983544002041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544002042 active site 983544002043 phosphorylation site [posttranslational modification] 983544002044 intermolecular recognition site; other site 983544002045 dimerization interface [polypeptide binding]; other site 983544002046 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983544002047 DNA binding residues [nucleotide binding] 983544002048 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 983544002049 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983544002050 E3 interaction surface; other site 983544002051 lipoyl attachment site [posttranslational modification]; other site 983544002052 e3 binding domain; Region: E3_binding; pfam02817 983544002053 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 983544002054 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 983544002055 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 983544002056 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 983544002057 TPP-binding site [chemical binding]; other site 983544002058 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 983544002059 dimer interface [polypeptide binding]; other site 983544002060 PYR/PP interface [polypeptide binding]; other site 983544002061 TPP binding site [chemical binding]; other site 983544002062 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 983544002063 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 983544002064 substrate binding pocket [chemical binding]; other site 983544002065 chain length determination region; other site 983544002066 substrate-Mg2+ binding site; other site 983544002067 catalytic residues [active] 983544002068 aspartate-rich region 1; other site 983544002069 active site lid residues [active] 983544002070 aspartate-rich region 2; other site 983544002071 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983544002072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983544002073 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 983544002074 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983544002075 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 983544002076 HlyD family secretion protein; Region: HlyD_3; pfam13437 983544002077 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983544002078 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 983544002079 starch binding outer membrane protein SusD; Region: SusD; cd08977 983544002080 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544002081 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 983544002082 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 983544002083 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544002084 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 983544002085 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 983544002086 dimer interface [polypeptide binding]; other site 983544002087 anticodon binding site; other site 983544002088 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 983544002089 homodimer interface [polypeptide binding]; other site 983544002090 motif 1; other site 983544002091 active site 983544002092 motif 2; other site 983544002093 GAD domain; Region: GAD; pfam02938 983544002094 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 983544002095 active site 983544002096 motif 3; other site 983544002097 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544002098 TPR motif; other site 983544002099 binding surface 983544002100 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 983544002101 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 983544002102 Cl- selectivity filter; other site 983544002103 Cl- binding residues [ion binding]; other site 983544002104 pore gating glutamate residue; other site 983544002105 dimer interface [polypeptide binding]; other site 983544002106 FOG: CBS domain [General function prediction only]; Region: COG0517 983544002107 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 983544002108 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 983544002109 nucleoside/Zn binding site; other site 983544002110 dimer interface [polypeptide binding]; other site 983544002111 catalytic motif [active] 983544002112 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 983544002113 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 983544002114 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 983544002115 PA/protease or protease-like domain interface [polypeptide binding]; other site 983544002116 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 983544002117 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 983544002118 Zn binding site [ion binding]; other site 983544002119 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544002120 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 983544002121 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 983544002122 TPP-binding site; other site 983544002123 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 983544002124 PYR/PP interface [polypeptide binding]; other site 983544002125 dimer interface [polypeptide binding]; other site 983544002126 TPP binding site [chemical binding]; other site 983544002127 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 983544002128 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 983544002129 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544002130 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983544002131 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544002132 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544002133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 983544002134 Phosphate transporter family; Region: PHO4; pfam01384 983544002135 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 983544002136 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983544002137 ligand binding site [chemical binding]; other site 983544002138 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 983544002139 ATP cone domain; Region: ATP-cone; pfam03477 983544002140 Class I ribonucleotide reductase; Region: RNR_I; cd01679 983544002141 active site 983544002142 dimer interface [polypeptide binding]; other site 983544002143 catalytic residues [active] 983544002144 effector binding site; other site 983544002145 R2 peptide binding site; other site 983544002146 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 983544002147 dimer interface [polypeptide binding]; other site 983544002148 putative radical transfer pathway; other site 983544002149 diiron center [ion binding]; other site 983544002150 tyrosyl radical; other site 983544002151 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 983544002152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544002153 active site 983544002154 phosphorylation site [posttranslational modification] 983544002155 intermolecular recognition site; other site 983544002156 dimerization interface [polypeptide binding]; other site 983544002157 LytTr DNA-binding domain; Region: LytTR; smart00850 983544002158 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983544002159 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983544002160 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544002161 binding surface 983544002162 TPR motif; other site 983544002163 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983544002164 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983544002165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544002166 binding surface 983544002167 TPR motif; other site 983544002168 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983544002169 Histidine kinase; Region: His_kinase; pfam06580 983544002170 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 983544002171 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 983544002172 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 983544002173 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 983544002174 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 983544002175 C-terminal peptidase (prc); Region: prc; TIGR00225 983544002176 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 983544002177 protein binding site [polypeptide binding]; other site 983544002178 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 983544002179 Catalytic dyad [active] 983544002180 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 983544002181 catalytic motif [active] 983544002182 Zn binding site [ion binding]; other site 983544002183 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 983544002184 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 983544002185 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 983544002186 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983544002187 active site 983544002188 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 983544002189 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 983544002190 5S rRNA interface [nucleotide binding]; other site 983544002191 CTC domain interface [polypeptide binding]; other site 983544002192 L16 interface [polypeptide binding]; other site 983544002193 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 983544002194 putative active site [active] 983544002195 catalytic residue [active] 983544002196 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 983544002197 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 983544002198 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 983544002199 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544002200 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 983544002201 active site 983544002202 Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675 983544002203 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544002204 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 983544002205 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 983544002206 active site 983544002207 Riboflavin kinase; Region: Flavokinase; pfam01687 983544002208 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 983544002209 seryl-tRNA synthetase; Provisional; Region: PRK05431 983544002210 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 983544002211 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 983544002212 motif 1; other site 983544002213 dimer interface [polypeptide binding]; other site 983544002214 active site 983544002215 motif 2; other site 983544002216 motif 3; other site 983544002217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983544002218 binding surface 983544002219 TPR motif; other site 983544002220 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 983544002221 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 983544002222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544002223 S-adenosylmethionine binding site [chemical binding]; other site 983544002224 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 983544002225 MgtE intracellular N domain; Region: MgtE_N; pfam03448 983544002226 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 983544002227 Divalent cation transporter; Region: MgtE; pfam01769 983544002228 Cupin domain; Region: Cupin_2; cl17218 983544002229 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 983544002230 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_14; cd12179 983544002231 putative ligand binding site [chemical binding]; other site 983544002232 putative NAD binding site [chemical binding]; other site 983544002233 catalytic site [active] 983544002234 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 983544002235 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983544002236 active site 983544002237 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983544002238 YtxH-like protein; Region: YtxH; pfam12732 983544002239 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983544002240 putative DNA binding site [nucleotide binding]; other site 983544002241 dimerization interface [polypeptide binding]; other site 983544002242 putative Zn2+ binding site [ion binding]; other site 983544002243 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544002244 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 983544002245 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 983544002246 putative acyl-acceptor binding pocket; other site 983544002247 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 983544002248 Pyrococcus aspartate kinase subunit, putative; Region: AspKin_pair; TIGR02078 983544002249 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 983544002250 nucleotide binding site [chemical binding]; other site 983544002251 substrate binding site [chemical binding]; other site 983544002252 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 983544002253 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 983544002254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983544002255 Coenzyme A binding pocket [chemical binding]; other site 983544002256 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 983544002257 AMP binding site [chemical binding]; other site 983544002258 metal binding site [ion binding]; metal-binding site 983544002259 active site 983544002260 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 983544002261 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 983544002262 Rab subfamily motif 1 (RabSF1); other site 983544002263 G1 box; other site 983544002264 GTP/Mg2+ binding site [chemical binding]; other site 983544002265 Rab subfamily motif 2 (RabSF2); other site 983544002266 Switch I region; other site 983544002267 G2 box; other site 983544002268 effector interaction site; other site 983544002269 GDI interaction site; other site 983544002270 Rab family motif 1 (RabF1); other site 983544002271 GEF interaction site [polypeptide binding]; other site 983544002272 Rab family motif 2 (RabF2); other site 983544002273 G3 box; other site 983544002274 Switch II region; other site 983544002275 Rab family motif 3 (RabF3); other site 983544002276 Rab family motif 4 (RabF4); other site 983544002277 Rab family motif 5 (RabF5); other site 983544002278 Rab subfamily motif 3 (RabSF3); other site 983544002279 G4 box; other site 983544002280 G5 box; other site 983544002281 Rab subfamily motif 4 (RabSF4); other site 983544002282 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983544002283 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983544002284 dimer interface [polypeptide binding]; other site 983544002285 phosphorylation site [posttranslational modification] 983544002286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544002287 ATP binding site [chemical binding]; other site 983544002288 Mg2+ binding site [ion binding]; other site 983544002289 G-X-G motif; other site 983544002290 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983544002291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544002292 active site 983544002293 phosphorylation site [posttranslational modification] 983544002294 intermolecular recognition site; other site 983544002295 dimerization interface [polypeptide binding]; other site 983544002296 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983544002297 dimer interface [polypeptide binding]; other site 983544002298 phosphorylation site [posttranslational modification] 983544002299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544002300 ATP binding site [chemical binding]; other site 983544002301 Mg2+ binding site [ion binding]; other site 983544002302 G-X-G motif; other site 983544002303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544002304 active site 983544002305 phosphorylation site [posttranslational modification] 983544002306 intermolecular recognition site; other site 983544002307 dimerization interface [polypeptide binding]; other site 983544002308 tellurium resistance terB-like protein; Region: terB_like; cd07177 983544002309 metal binding site [ion binding]; metal-binding site 983544002310 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 983544002311 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 983544002312 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983544002313 ATP binding site [chemical binding]; other site 983544002314 putative Mg++ binding site [ion binding]; other site 983544002315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983544002316 nucleotide binding region [chemical binding]; other site 983544002317 ATP-binding site [chemical binding]; other site 983544002318 TRCF domain; Region: TRCF; pfam03461 983544002319 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 983544002320 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 983544002321 catalytic residues [active] 983544002322 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 983544002323 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 983544002324 dimer interface [polypeptide binding]; other site 983544002325 catalytic triad [active] 983544002326 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 983544002327 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 983544002328 active site 983544002329 HIGH motif; other site 983544002330 KMSKS motif; other site 983544002331 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 983544002332 tRNA binding surface [nucleotide binding]; other site 983544002333 anticodon binding site; other site 983544002334 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 983544002335 dimer interface [polypeptide binding]; other site 983544002336 putative tRNA-binding site [nucleotide binding]; other site 983544002337 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 983544002338 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983544002339 ligand binding site [chemical binding]; other site 983544002340 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 983544002341 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 983544002342 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 983544002343 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 983544002344 RNA binding site [nucleotide binding]; other site 983544002345 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544002346 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983544002347 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544002348 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 983544002349 putative catalytic site [active] 983544002350 putative metal binding site [ion binding]; other site 983544002351 putative phosphate binding site [ion binding]; other site 983544002352 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544002353 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983544002354 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544002355 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 983544002356 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 983544002357 active site 983544002358 dimer interface [polypeptide binding]; other site 983544002359 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 983544002360 dimer interface [polypeptide binding]; other site 983544002361 active site 983544002362 putative peptidase; Provisional; Region: PRK11649 983544002363 Peptidase family M23; Region: Peptidase_M23; pfam01551 983544002364 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 983544002365 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 983544002366 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 983544002367 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 983544002368 dimer interface [polypeptide binding]; other site 983544002369 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 983544002370 active site 983544002371 Fe binding site [ion binding]; other site 983544002372 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 983544002373 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 983544002374 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 983544002375 active site 983544002376 nucleophile elbow; other site 983544002377 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 983544002378 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 983544002379 GIY-YIG motif/motif A; other site 983544002380 active site 983544002381 catalytic site [active] 983544002382 putative DNA binding site [nucleotide binding]; other site 983544002383 metal binding site [ion binding]; metal-binding site 983544002384 UvrB/uvrC motif; Region: UVR; pfam02151 983544002385 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 983544002386 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 983544002387 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 983544002388 ATP-grasp domain; Region: ATP-grasp_4; cl17255 983544002389 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 983544002390 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 983544002391 putative active site [active] 983544002392 Zn binding site [ion binding]; other site 983544002393 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 983544002394 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 983544002395 Response regulator receiver domain; Region: Response_reg; pfam00072 983544002396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544002397 active site 983544002398 phosphorylation site [posttranslational modification] 983544002399 intermolecular recognition site; other site 983544002400 dimerization interface [polypeptide binding]; other site 983544002401 lipoprotein signal peptidase; Provisional; Region: PRK14788 983544002402 lipoprotein signal peptidase; Provisional; Region: PRK14787 983544002403 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 983544002404 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 983544002405 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983544002406 active site 983544002407 HIGH motif; other site 983544002408 nucleotide binding site [chemical binding]; other site 983544002409 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983544002410 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983544002411 active site 983544002412 KMSKS motif; other site 983544002413 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 983544002414 tRNA binding surface [nucleotide binding]; other site 983544002415 anticodon binding site; other site 983544002416 DNA repair protein RadA; Provisional; Region: PRK11823 983544002417 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 983544002418 Walker A motif/ATP binding site; other site 983544002419 ATP binding site [chemical binding]; other site 983544002420 Walker B motif; other site 983544002421 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 983544002422 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 983544002423 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 983544002424 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 983544002425 tetramerization interface [polypeptide binding]; other site 983544002426 active site 983544002427 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 983544002428 pantoate--beta-alanine ligase; Region: panC; TIGR00018 983544002429 active site 983544002430 nucleotide binding site [chemical binding]; other site 983544002431 HIGH motif; other site 983544002432 KMSKS motif; other site 983544002433 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 983544002434 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 983544002435 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 983544002436 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 983544002437 glutaminase active site [active] 983544002438 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 983544002439 dimer interface [polypeptide binding]; other site 983544002440 active site 983544002441 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 983544002442 dimer interface [polypeptide binding]; other site 983544002443 active site 983544002444 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544002445 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983544002446 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 983544002447 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544002448 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 983544002449 catalytic triad [active] 983544002450 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 983544002451 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 983544002452 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 983544002453 alpha subunit interaction interface [polypeptide binding]; other site 983544002454 Walker A motif; other site 983544002455 ATP binding site [chemical binding]; other site 983544002456 Walker B motif; other site 983544002457 inhibitor binding site; inhibition site 983544002458 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 983544002459 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 983544002460 gamma subunit interface [polypeptide binding]; other site 983544002461 LBP interface [polypeptide binding]; other site 983544002462 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 983544002463 Catalytic site [active] 983544002464 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 983544002465 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 983544002466 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983544002467 catalytic residue [active] 983544002468 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 983544002469 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 983544002470 AAA domain; Region: AAA_26; pfam13500 983544002471 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 983544002472 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 983544002473 inhibitor-cofactor binding pocket; inhibition site 983544002474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544002475 catalytic residue [active] 983544002476 Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695 983544002477 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 983544002478 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 983544002479 active site 983544002480 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 983544002481 biotin synthase; Region: bioB; TIGR00433 983544002482 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983544002483 FeS/SAM binding site; other site 983544002484 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 983544002485 Cupin-like domain; Region: Cupin_8; pfam13621 983544002486 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 983544002487 RecX family; Region: RecX; pfam02631 983544002488 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544002489 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 983544002490 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544002491 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 983544002492 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983544002493 N-terminal plug; other site 983544002494 ligand-binding site [chemical binding]; other site 983544002495 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 983544002496 Recombination protein O N terminal; Region: RecO_N; pfam11967 983544002497 Recombination protein O C terminal; Region: RecO_C; pfam02565 983544002498 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 983544002499 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 983544002500 glutamate dehydrogenase; Provisional; Region: PRK09414 983544002501 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 983544002502 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 983544002503 NAD(P) binding site [chemical binding]; other site 983544002504 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 983544002505 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 983544002506 homodimer interface [polypeptide binding]; other site 983544002507 substrate-cofactor binding pocket; other site 983544002508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544002509 catalytic residue [active] 983544002510 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 983544002511 DinB superfamily; Region: DinB_2; pfam12867 983544002512 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983544002513 ArsC family; Region: ArsC; pfam03960 983544002514 EamA-like transporter family; Region: EamA; pfam00892 983544002515 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 983544002516 EamA-like transporter family; Region: EamA; pfam00892 983544002517 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 983544002518 active site 983544002519 hypothetical protein; Provisional; Region: PRK11820 983544002520 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 983544002521 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 983544002522 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 983544002523 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 983544002524 catalytic site [active] 983544002525 G-X2-G-X-G-K; other site 983544002526 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 983544002527 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 983544002528 active site 983544002529 (T/H)XGH motif; other site 983544002530 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 983544002531 CheB methylesterase; Region: CheB_methylest; pfam01339 983544002532 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 983544002533 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 983544002534 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 983544002535 PAS domain; Region: PAS_10; pfam13596 983544002536 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 983544002537 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 983544002538 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983544002539 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983544002540 dimer interface [polypeptide binding]; other site 983544002541 phosphorylation site [posttranslational modification] 983544002542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544002543 ATP binding site [chemical binding]; other site 983544002544 Mg2+ binding site [ion binding]; other site 983544002545 G-X-G motif; other site 983544002546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544002547 Response regulator receiver domain; Region: Response_reg; pfam00072 983544002548 active site 983544002549 phosphorylation site [posttranslational modification] 983544002550 intermolecular recognition site; other site 983544002551 dimerization interface [polypeptide binding]; other site 983544002552 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 983544002553 BON domain; Region: BON; pfam04972 983544002554 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 983544002555 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 983544002556 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 983544002557 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 983544002558 Flavodoxin; Region: Flavodoxin_1; pfam00258 983544002559 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 983544002560 FAD binding pocket [chemical binding]; other site 983544002561 conserved FAD binding motif [chemical binding]; other site 983544002562 phosphate binding motif [ion binding]; other site 983544002563 beta-alpha-beta structure motif; other site 983544002564 NAD binding pocket [chemical binding]; other site 983544002565 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 983544002566 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 983544002567 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 983544002568 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 983544002569 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 983544002570 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 983544002571 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 983544002572 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 983544002573 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 983544002574 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 983544002575 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983544002576 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544002577 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 983544002578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983544002579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983544002580 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 983544002581 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983544002582 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983544002583 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 983544002584 HlyD family secretion protein; Region: HlyD_3; pfam13437 983544002585 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 983544002586 dimerization interface [polypeptide binding]; other site 983544002587 putative DNA binding site [nucleotide binding]; other site 983544002588 putative Zn2+ binding site [ion binding]; other site 983544002589 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 983544002590 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 983544002591 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 983544002592 dimer interface [polypeptide binding]; other site 983544002593 motif 1; other site 983544002594 active site 983544002595 motif 2; other site 983544002596 motif 3; other site 983544002597 Colicin V production protein; Region: Colicin_V; pfam02674 983544002598 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 983544002599 active site clefts [active] 983544002600 zinc binding site [ion binding]; other site 983544002601 dimer interface [polypeptide binding]; other site 983544002602 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 983544002603 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 983544002604 Sulfate transporter family; Region: Sulfate_transp; pfam00916 983544002605 Sulfate transporter family; Region: Sulfate_transp; pfam00916 983544002606 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 983544002607 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 983544002608 Conotoxin; Region: Conotoxin; pfam02950 983544002609 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 983544002610 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983544002611 Ligand Binding Site [chemical binding]; other site 983544002612 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 983544002613 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 983544002614 Sulfate transporter family; Region: Sulfate_transp; pfam00916 983544002615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544002616 binding surface 983544002617 TPR repeat; Region: TPR_11; pfam13414 983544002618 TPR motif; other site 983544002619 Bacterial SH3 domain homologues; Region: SH3b; smart00287 983544002620 Oxygen tolerance; Region: BatD; pfam13584 983544002621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544002622 TPR motif; other site 983544002623 binding surface 983544002624 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983544002625 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 983544002626 metal ion-dependent adhesion site (MIDAS); other site 983544002627 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 983544002628 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 983544002629 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 983544002630 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 983544002631 metal ion-dependent adhesion site (MIDAS); other site 983544002632 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 983544002633 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 983544002634 metal ion-dependent adhesion site (MIDAS); other site 983544002635 MoxR-like ATPases [General function prediction only]; Region: COG0714 983544002636 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 983544002637 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 983544002638 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 983544002639 active site 983544002640 catalytic tetrad [active] 983544002641 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 983544002642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983544002643 NAD(P) binding site [chemical binding]; other site 983544002644 active site 983544002645 Divergent AAA domain; Region: AAA_4; pfam04326 983544002646 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 983544002647 Uncharacterized conserved protein [Function unknown]; Region: COG3743 983544002648 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 983544002649 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983544002650 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 983544002651 ligand binding site [chemical binding]; other site 983544002652 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 983544002653 aldehyde dehydrogenase family 7 member; Region: PLN02315 983544002654 tetrameric interface [polypeptide binding]; other site 983544002655 NAD binding site [chemical binding]; other site 983544002656 catalytic residues [active] 983544002657 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 983544002658 catalytic nucleophile [active] 983544002659 Bacterial Ig-like domain; Region: Big_5; pfam13205 983544002660 MG2 domain; Region: A2M_N; pfam01835 983544002661 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 983544002662 Alpha-2-macroglobulin family; Region: A2M; pfam00207 983544002663 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 983544002664 surface patch; other site 983544002665 thioester region; other site 983544002666 specificity defining residues; other site 983544002667 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 983544002668 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 983544002669 Transglycosylase; Region: Transgly; pfam00912 983544002670 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 983544002671 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 983544002672 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 983544002673 Interdomain contacts; other site 983544002674 Cytokine receptor motif; other site 983544002675 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 983544002676 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 983544002677 TPR repeat; Region: TPR_11; pfam13414 983544002678 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544002679 TPR motif; other site 983544002680 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983544002681 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 983544002682 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983544002683 ligand binding site [chemical binding]; other site 983544002684 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 983544002685 hydroxyglutarate oxidase; Provisional; Region: PRK11728 983544002686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983544002687 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 983544002688 Walker A/P-loop; other site 983544002689 ATP binding site [chemical binding]; other site 983544002690 Q-loop/lid; other site 983544002691 ABC transporter signature motif; other site 983544002692 Walker B; other site 983544002693 D-loop; other site 983544002694 H-loop/switch region; other site 983544002695 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 983544002696 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 983544002697 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 983544002698 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 983544002699 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 983544002700 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 983544002701 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 983544002702 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 983544002703 active site 983544002704 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 983544002705 dimer interface [polypeptide binding]; other site 983544002706 substrate binding site [chemical binding]; other site 983544002707 catalytic residues [active] 983544002708 thymidine kinase; Provisional; Region: PRK04296 983544002709 DoxX-like family; Region: DoxX_2; pfam13564 983544002710 Predicted methyltransferases [General function prediction only]; Region: COG0313 983544002711 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 983544002712 putative SAM binding site [chemical binding]; other site 983544002713 putative homodimer interface [polypeptide binding]; other site 983544002714 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 983544002715 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 983544002716 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 983544002717 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983544002718 NRDE protein; Region: NRDE; cl01315 983544002719 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 983544002720 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 983544002721 putative uracil binding site [chemical binding]; other site 983544002722 putative active site [active] 983544002723 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 983544002724 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 983544002725 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 983544002726 DHH family; Region: DHH; pfam01368 983544002727 DHHA1 domain; Region: DHHA1; pfam02272 983544002728 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 983544002729 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983544002730 ligand binding site [chemical binding]; other site 983544002731 H+ Antiporter protein; Region: 2A0121; TIGR00900 983544002732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983544002733 putative substrate translocation pore; other site 983544002734 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 983544002735 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 983544002736 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 983544002737 putative active site [active] 983544002738 putative metal binding site [ion binding]; other site 983544002739 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 983544002740 active site 983544002741 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 983544002742 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 983544002743 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 983544002744 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 983544002745 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983544002746 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983544002747 dimer interface [polypeptide binding]; other site 983544002748 phosphorylation site [posttranslational modification] 983544002749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544002750 ATP binding site [chemical binding]; other site 983544002751 Mg2+ binding site [ion binding]; other site 983544002752 G-X-G motif; other site 983544002753 Response regulator receiver domain; Region: Response_reg; pfam00072 983544002754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544002755 active site 983544002756 phosphorylation site [posttranslational modification] 983544002757 intermolecular recognition site; other site 983544002758 dimerization interface [polypeptide binding]; other site 983544002759 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 983544002760 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 983544002761 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 983544002762 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 983544002763 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983544002764 ligand binding site [chemical binding]; other site 983544002765 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 983544002766 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 983544002767 substrate-cofactor binding pocket; other site 983544002768 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544002769 catalytic residue [active] 983544002770 putative recombination protein RecB; Provisional; Region: PRK13909 983544002771 Family description; Region: UvrD_C_2; pfam13538 983544002772 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 983544002773 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 983544002774 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 983544002775 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 983544002776 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 983544002777 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 983544002778 active site 983544002779 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 983544002780 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 983544002781 substrate binding site [chemical binding]; other site 983544002782 ATP binding site [chemical binding]; other site 983544002783 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 983544002784 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 983544002785 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 983544002786 RNA/DNA hybrid binding site [nucleotide binding]; other site 983544002787 active site 983544002788 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 983544002789 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 983544002790 active site 983544002791 substrate binding site [chemical binding]; other site 983544002792 cosubstrate binding site; other site 983544002793 catalytic site [active] 983544002794 acyl carrier protein; Provisional; Region: acpP; PRK00982 983544002795 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 983544002796 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 983544002797 dimer interface [polypeptide binding]; other site 983544002798 active site 983544002799 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 983544002800 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 983544002801 dimerization interface [polypeptide binding]; other site 983544002802 active site 983544002803 metal binding site [ion binding]; metal-binding site 983544002804 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 983544002805 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 983544002806 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 983544002807 domain interfaces; other site 983544002808 active site 983544002809 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 983544002810 active site 983544002811 DNA polymerase IV; Validated; Region: PRK02406 983544002812 DNA binding site [nucleotide binding] 983544002813 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 983544002814 putative active site [active] 983544002815 putative metal binding residues [ion binding]; other site 983544002816 signature motif; other site 983544002817 putative dimer interface [polypeptide binding]; other site 983544002818 putative phosphate binding site [ion binding]; other site 983544002819 YCII-related domain; Region: YCII; cl00999 983544002820 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 983544002821 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 983544002822 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544002823 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 983544002824 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 983544002825 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 983544002826 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 983544002827 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 983544002828 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 983544002829 carboxyltransferase (CT) interaction site; other site 983544002830 biotinylation site [posttranslational modification]; other site 983544002831 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 983544002832 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 983544002833 dimer interface [polypeptide binding]; other site 983544002834 active site 983544002835 CoA binding pocket [chemical binding]; other site 983544002836 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 983544002837 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 983544002838 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 983544002839 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 983544002840 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 983544002841 Lumazine binding domain; Region: Lum_binding; pfam00677 983544002842 Lumazine binding domain; Region: Lum_binding; pfam00677 983544002843 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983544002844 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 983544002845 dimer interface [polypeptide binding]; other site 983544002846 substrate binding site [chemical binding]; other site 983544002847 metal binding site [ion binding]; metal-binding site 983544002848 Ribosome-binding factor A; Region: RBFA; pfam02033 983544002849 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 983544002850 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983544002851 FtsX-like permease family; Region: FtsX; pfam02687 983544002852 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 983544002853 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 983544002854 FMN binding site [chemical binding]; other site 983544002855 active site 983544002856 catalytic residues [active] 983544002857 substrate binding site [chemical binding]; other site 983544002858 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 983544002859 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 983544002860 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983544002861 FeS/SAM binding site; other site 983544002862 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544002863 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544002864 GTP-binding protein LepA; Provisional; Region: PRK05433 983544002865 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 983544002866 G1 box; other site 983544002867 putative GEF interaction site [polypeptide binding]; other site 983544002868 GTP/Mg2+ binding site [chemical binding]; other site 983544002869 Switch I region; other site 983544002870 G2 box; other site 983544002871 G3 box; other site 983544002872 Switch II region; other site 983544002873 G4 box; other site 983544002874 G5 box; other site 983544002875 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 983544002876 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 983544002877 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 983544002878 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 983544002879 TrkA-N domain; Region: TrkA_N; pfam02254 983544002880 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983544002881 Ligand Binding Site [chemical binding]; other site 983544002882 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 983544002883 Sulfate transporter family; Region: Sulfate_transp; pfam00916 983544002884 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 983544002885 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 983544002886 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 983544002887 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 983544002888 active site 983544002889 catalytic residues [active] 983544002890 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 983544002891 Zn binding site [ion binding]; other site 983544002892 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 983544002893 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 983544002894 active site 983544002895 HIGH motif; other site 983544002896 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 983544002897 active site 983544002898 KMSKS motif; other site 983544002899 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 983544002900 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 983544002901 Zn binding site [ion binding]; other site 983544002902 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544002903 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 983544002904 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 983544002905 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 983544002906 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 983544002907 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 983544002908 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983544002909 active site 983544002910 HIGH motif; other site 983544002911 nucleotide binding site [chemical binding]; other site 983544002912 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983544002913 active site 983544002914 KMSKS motif; other site 983544002915 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 983544002916 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 983544002917 Dihydroneopterin aldolase; Region: FolB; pfam02152 983544002918 active site 983544002919 LysE type translocator; Region: LysE; cl00565 983544002920 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 983544002921 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 983544002922 ribonuclease R; Region: RNase_R; TIGR02063 983544002923 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 983544002924 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 983544002925 RNB domain; Region: RNB; pfam00773 983544002926 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 983544002927 RNA binding site [nucleotide binding]; other site 983544002928 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 983544002929 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 983544002930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 983544002931 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 983544002932 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983544002933 ligand binding site [chemical binding]; other site 983544002934 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983544002935 ligand binding site [chemical binding]; other site 983544002936 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 983544002937 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 983544002938 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 983544002939 protein binding site [polypeptide binding]; other site 983544002940 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 983544002941 Catalytic dyad [active] 983544002942 ribonuclease P; Reviewed; Region: rnpA; PRK01903 983544002943 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983544002944 non-specific DNA binding site [nucleotide binding]; other site 983544002945 salt bridge; other site 983544002946 sequence-specific DNA binding site [nucleotide binding]; other site 983544002947 Predicted transcriptional regulator [Transcription]; Region: COG2932 983544002948 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 983544002949 Catalytic site [active] 983544002950 Frag1/DRAM/Sfk1 family; Region: Frag1; pfam10277 983544002951 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 983544002952 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 983544002953 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 983544002954 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 983544002955 Methyltransferase domain; Region: Methyltransf_23; pfam13489 983544002956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544002957 S-adenosylmethionine binding site [chemical binding]; other site 983544002958 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 983544002959 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 983544002960 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 983544002961 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 983544002962 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 983544002963 DNA polymerase III subunit delta'; Validated; Region: PRK05564 983544002964 DNA polymerase III subunit delta'; Validated; Region: PRK08485 983544002965 Phosphoglycerate kinase; Region: PGK; pfam00162 983544002966 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 983544002967 substrate binding site [chemical binding]; other site 983544002968 hinge regions; other site 983544002969 ADP binding site [chemical binding]; other site 983544002970 catalytic site [active] 983544002971 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 983544002972 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983544002973 catalytic residue [active] 983544002974 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 983544002975 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 983544002976 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 983544002977 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 983544002978 Peptidase family M23; Region: Peptidase_M23; pfam01551 983544002979 GH3 auxin-responsive promoter; Region: GH3; pfam03321 983544002980 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 983544002981 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 983544002982 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 983544002983 NAD binding site [chemical binding]; other site 983544002984 substrate binding site [chemical binding]; other site 983544002985 homodimer interface [polypeptide binding]; other site 983544002986 active site 983544002987 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 983544002988 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 983544002989 substrate binding site; other site 983544002990 tetramer interface; other site 983544002991 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 983544002992 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 983544002993 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 983544002994 NADP binding site [chemical binding]; other site 983544002995 active site 983544002996 putative substrate binding site [chemical binding]; other site 983544002997 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 983544002998 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 983544002999 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 983544003000 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 983544003001 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 983544003002 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 983544003003 NAD binding site [chemical binding]; other site 983544003004 substrate binding site [chemical binding]; other site 983544003005 homodimer interface [polypeptide binding]; other site 983544003006 active site 983544003007 O-Antigen ligase; Region: Wzy_C; pfam04932 983544003008 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 983544003009 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 983544003010 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 983544003011 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 983544003012 trimer interface [polypeptide binding]; other site 983544003013 active site 983544003014 substrate binding site [chemical binding]; other site 983544003015 CoA binding site [chemical binding]; other site 983544003016 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983544003017 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 983544003018 putative ADP-binding pocket [chemical binding]; other site 983544003019 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983544003020 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 983544003021 putative ADP-binding pocket [chemical binding]; other site 983544003022 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u5; cd10929 983544003023 putative active site [active] 983544003024 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 983544003025 putative active site [active] 983544003026 putative cosubstrate binding site; other site 983544003027 putative substrate binding site [chemical binding]; other site 983544003028 catalytic site [active] 983544003029 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983544003030 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 983544003031 putative ADP-binding pocket [chemical binding]; other site 983544003032 Bacterial sugar transferase; Region: Bac_transf; pfam02397 983544003033 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 983544003034 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 983544003035 putative trimer interface [polypeptide binding]; other site 983544003036 putative CoA binding site [chemical binding]; other site 983544003037 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 983544003038 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 983544003039 inhibitor-cofactor binding pocket; inhibition site 983544003040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544003041 catalytic residue [active] 983544003042 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 983544003043 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 983544003044 NAD(P) binding site [chemical binding]; other site 983544003045 homodimer interface [polypeptide binding]; other site 983544003046 substrate binding site [chemical binding]; other site 983544003047 active site 983544003048 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 983544003049 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 983544003050 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 983544003051 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 983544003052 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 983544003053 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 983544003054 NAD binding site [chemical binding]; other site 983544003055 putative substrate binding site 2 [chemical binding]; other site 983544003056 putative substrate binding site 1 [chemical binding]; other site 983544003057 active site 983544003058 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 983544003059 Bacterial sugar transferase; Region: Bac_transf; pfam02397 983544003060 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983544003061 active site 983544003062 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 983544003063 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 983544003064 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 983544003065 AMP binding site [chemical binding]; other site 983544003066 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 983544003067 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 983544003068 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 983544003069 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 983544003070 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983544003071 active site 983544003072 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 983544003073 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 983544003074 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983544003075 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983544003076 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 983544003077 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 983544003078 FAD binding pocket [chemical binding]; other site 983544003079 FAD binding motif [chemical binding]; other site 983544003080 phosphate binding motif [ion binding]; other site 983544003081 beta-alpha-beta structure motif; other site 983544003082 NAD(p) ribose binding residues [chemical binding]; other site 983544003083 NAD binding pocket [chemical binding]; other site 983544003084 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 983544003085 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983544003086 catalytic loop [active] 983544003087 iron binding site [ion binding]; other site 983544003088 Predicted transcriptional regulators [Transcription]; Region: COG1695 983544003089 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 983544003090 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 983544003091 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 983544003092 Walker A/P-loop; other site 983544003093 ATP binding site [chemical binding]; other site 983544003094 Q-loop/lid; other site 983544003095 ABC transporter signature motif; other site 983544003096 Walker B; other site 983544003097 D-loop; other site 983544003098 H-loop/switch region; other site 983544003099 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 983544003100 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 983544003101 ATP synthase A chain; Region: ATP-synt_A; cl00413 983544003102 ATP synthase subunit C; Region: ATP-synt_C; cl00466 983544003103 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 983544003104 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 983544003105 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 983544003106 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 983544003107 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 983544003108 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 983544003109 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 983544003110 beta subunit interaction interface [polypeptide binding]; other site 983544003111 Walker A motif; other site 983544003112 ATP binding site [chemical binding]; other site 983544003113 Walker B motif; other site 983544003114 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 983544003115 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 983544003116 core domain interface [polypeptide binding]; other site 983544003117 delta subunit interface [polypeptide binding]; other site 983544003118 epsilon subunit interface [polypeptide binding]; other site 983544003119 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 983544003120 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 983544003121 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 983544003122 trimer interface [polypeptide binding]; other site 983544003123 active site 983544003124 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 983544003125 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 983544003126 active site 983544003127 Substrate binding site; other site 983544003128 Mg++ binding site; other site 983544003129 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 983544003130 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 983544003131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544003132 binding surface 983544003133 TPR repeat; Region: TPR_11; pfam13414 983544003134 TPR motif; other site 983544003135 Tetratricopeptide repeat; Region: TPR_16; pfam13432 983544003136 Tetratricopeptide repeat; Region: TPR_9; pfam13371 983544003137 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 983544003138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544003139 binding surface 983544003140 TPR motif; other site 983544003141 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 983544003142 Peptidase family M23; Region: Peptidase_M23; pfam01551 983544003143 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 983544003144 Sporulation related domain; Region: SPOR; pfam05036 983544003145 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 983544003146 DNA protecting protein DprA; Region: dprA; TIGR00732 983544003147 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 983544003148 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 983544003149 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 983544003150 active site 983544003151 HIGH motif; other site 983544003152 dimer interface [polypeptide binding]; other site 983544003153 KMSKS motif; other site 983544003154 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 983544003155 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 983544003156 putative acyl-acceptor binding pocket; other site 983544003157 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983544003158 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544003159 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983544003160 DNA binding residues [nucleotide binding] 983544003161 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 983544003162 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 983544003163 hexamer interface [polypeptide binding]; other site 983544003164 Walker A motif; other site 983544003165 ATP binding site [chemical binding]; other site 983544003166 Walker B motif; other site 983544003167 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 983544003168 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 983544003169 active site residue [active] 983544003170 PSP1 C-terminal conserved region; Region: PSP1; cl00770 983544003171 GldH lipoprotein; Region: GldH_lipo; pfam14109 983544003172 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 983544003173 Transglycosylase; Region: Transgly; pfam00912 983544003174 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 983544003175 GLPGLI family protein; Region: GLPGLI; TIGR01200 983544003176 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 983544003177 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544003178 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 983544003179 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 983544003180 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 983544003181 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 983544003182 Walker A/P-loop; other site 983544003183 ATP binding site [chemical binding]; other site 983544003184 Q-loop/lid; other site 983544003185 ABC transporter signature motif; other site 983544003186 Walker B; other site 983544003187 D-loop; other site 983544003188 H-loop/switch region; other site 983544003189 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 983544003190 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 983544003191 Walker A/P-loop; other site 983544003192 ATP binding site [chemical binding]; other site 983544003193 Q-loop/lid; other site 983544003194 ABC transporter signature motif; other site 983544003195 Walker B; other site 983544003196 D-loop; other site 983544003197 H-loop/switch region; other site 983544003198 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 983544003199 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 983544003200 active site 983544003201 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 983544003202 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 983544003203 aromatic chitin/cellulose binding site residues [chemical binding]; other site 983544003204 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544003205 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 983544003206 active site 983544003207 catalytic site [active] 983544003208 substrate binding site [chemical binding]; other site 983544003209 Beta-lactamase; Region: Beta-lactamase; pfam00144 983544003210 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 983544003211 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; cl17557 983544003212 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 983544003213 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 983544003214 DNA binding site [nucleotide binding] 983544003215 active site 983544003216 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 983544003217 Domain of unknown function DUF21; Region: DUF21; pfam01595 983544003218 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 983544003219 cytochrome c-550; Provisional; Region: psbV; cl17239 983544003220 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 983544003221 Cytochrome c; Region: Cytochrom_C; pfam00034 983544003222 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 983544003223 dimer interface [polypeptide binding]; other site 983544003224 allosteric magnesium binding site [ion binding]; other site 983544003225 active site 983544003226 aspartate-rich active site metal binding site; other site 983544003227 Schiff base residues; other site 983544003228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 983544003229 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 983544003230 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 983544003231 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 983544003232 putative substrate binding pocket [chemical binding]; other site 983544003233 trimer interface [polypeptide binding]; other site 983544003234 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 983544003235 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 983544003236 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 983544003237 substrate binding site [chemical binding]; other site 983544003238 active site 983544003239 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 983544003240 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 983544003241 domain interfaces; other site 983544003242 active site 983544003243 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 983544003244 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 983544003245 active site 983544003246 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 983544003247 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 983544003248 tRNA; other site 983544003249 putative tRNA binding site [nucleotide binding]; other site 983544003250 putative NADP binding site [chemical binding]; other site 983544003251 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 983544003252 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 983544003253 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983544003254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983544003255 TraB family; Region: TraB; pfam01963 983544003256 ferrochelatase; Reviewed; Region: hemH; PRK00035 983544003257 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 983544003258 C-terminal domain interface [polypeptide binding]; other site 983544003259 active site 983544003260 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 983544003261 active site 983544003262 N-terminal domain interface [polypeptide binding]; other site 983544003263 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 983544003264 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 983544003265 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 983544003266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983544003267 HAMP domain; Region: HAMP; pfam00672 983544003268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983544003269 dimer interface [polypeptide binding]; other site 983544003270 phosphorylation site [posttranslational modification] 983544003271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544003272 ATP binding site [chemical binding]; other site 983544003273 Mg2+ binding site [ion binding]; other site 983544003274 G-X-G motif; other site 983544003275 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 983544003276 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983544003277 substrate binding site [chemical binding]; other site 983544003278 oxyanion hole (OAH) forming residues; other site 983544003279 trimer interface [polypeptide binding]; other site 983544003280 Helix-turn-helix domain; Region: HTH_18; pfam12833 983544003281 TraB family; Region: TraB; pfam01963 983544003282 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 983544003283 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 983544003284 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983544003285 FeS/SAM binding site; other site 983544003286 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983544003287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983544003288 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 983544003289 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 983544003290 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 983544003291 homodimer interface [polypeptide binding]; other site 983544003292 putative substrate binding pocket [chemical binding]; other site 983544003293 diiron center [ion binding]; other site 983544003294 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 983544003295 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 983544003296 putative acyl-acceptor binding pocket; other site 983544003297 Disulphide isomerase; Region: Disulph_isomer; pfam06491 983544003298 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 983544003299 putative metal binding site [ion binding]; other site 983544003300 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 983544003301 HSP70 interaction site [polypeptide binding]; other site 983544003302 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983544003303 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544003304 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 983544003305 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 983544003306 ABC-ATPase subunit interface; other site 983544003307 dimer interface [polypeptide binding]; other site 983544003308 putative PBP binding regions; other site 983544003309 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 983544003310 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 983544003311 ABC-ATPase subunit interface; other site 983544003312 dimer interface [polypeptide binding]; other site 983544003313 putative PBP binding regions; other site 983544003314 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 983544003315 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 983544003316 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 983544003317 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 983544003318 intersubunit interface [polypeptide binding]; other site 983544003319 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 983544003320 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 983544003321 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 983544003322 FeoA domain; Region: FeoA; pfam04023 983544003323 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 983544003324 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 983544003325 G1 box; other site 983544003326 GTP/Mg2+ binding site [chemical binding]; other site 983544003327 Switch I region; other site 983544003328 G2 box; other site 983544003329 G3 box; other site 983544003330 Switch II region; other site 983544003331 G4 box; other site 983544003332 G5 box; other site 983544003333 Nucleoside recognition; Region: Gate; pfam07670 983544003334 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 983544003335 Nucleoside recognition; Region: Gate; pfam07670 983544003336 FeoA domain; Region: FeoA; pfam04023 983544003337 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 983544003338 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 983544003339 Cu(I) binding site [ion binding]; other site 983544003340 RIP metalloprotease RseP; Region: TIGR00054 983544003341 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 983544003342 active site 983544003343 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 983544003344 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 983544003345 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 983544003346 putative substrate binding region [chemical binding]; other site 983544003347 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 983544003348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983544003349 NAD(P) binding site [chemical binding]; other site 983544003350 active site 983544003351 SnoaL-like domain; Region: SnoaL_3; pfam13474 983544003352 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 983544003353 Asp-box motif; other site 983544003354 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544003355 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 983544003356 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 983544003357 active site 983544003358 Zn binding site [ion binding]; other site 983544003359 Domain of unknown function DUF11; Region: DUF11; pfam01345 983544003360 Domain of unknown function DUF11; Region: DUF11; pfam01345 983544003361 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 983544003362 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 983544003363 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 983544003364 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983544003365 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 983544003366 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 983544003367 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983544003368 ligand binding site [chemical binding]; other site 983544003369 FOG: CBS domain [General function prediction only]; Region: COG0517 983544003370 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 983544003371 E3 Ubiquitin ligase; Region: GIDE; pfam12483 983544003372 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 983544003373 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 983544003374 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 983544003375 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 983544003376 dimer interface [polypeptide binding]; other site 983544003377 ssDNA binding site [nucleotide binding]; other site 983544003378 tetramer (dimer of dimers) interface [polypeptide binding]; other site 983544003379 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 983544003380 putative catalytic site [active] 983544003381 putative metal binding site [ion binding]; other site 983544003382 putative phosphate binding site [ion binding]; other site 983544003383 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 983544003384 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 983544003385 HflX GTPase family; Region: HflX; cd01878 983544003386 G1 box; other site 983544003387 GTP/Mg2+ binding site [chemical binding]; other site 983544003388 Switch I region; other site 983544003389 G2 box; other site 983544003390 G3 box; other site 983544003391 Switch II region; other site 983544003392 G4 box; other site 983544003393 G5 box; other site 983544003394 Transglycosylase; Region: Transgly; pfam00912 983544003395 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 983544003396 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 983544003397 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 983544003398 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 983544003399 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 983544003400 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983544003401 Walker A/P-loop; other site 983544003402 ATP binding site [chemical binding]; other site 983544003403 Q-loop/lid; other site 983544003404 ABC transporter signature motif; other site 983544003405 Walker B; other site 983544003406 D-loop; other site 983544003407 H-loop/switch region; other site 983544003408 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 983544003409 Fe-S metabolism associated domain; Region: SufE; cl00951 983544003410 META domain; Region: META; pfam03724 983544003411 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 983544003412 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 983544003413 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983544003414 catalytic residue [active] 983544003415 FeS assembly protein SufD; Region: sufD; TIGR01981 983544003416 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 983544003417 FeS assembly ATPase SufC; Region: sufC; TIGR01978 983544003418 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 983544003419 Walker A/P-loop; other site 983544003420 ATP binding site [chemical binding]; other site 983544003421 Q-loop/lid; other site 983544003422 ABC transporter signature motif; other site 983544003423 Walker B; other site 983544003424 D-loop; other site 983544003425 H-loop/switch region; other site 983544003426 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 983544003427 putative ABC transporter; Region: ycf24; CHL00085 983544003428 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 983544003429 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 983544003430 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 983544003431 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 983544003432 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 983544003433 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544003434 thiamine-monophosphate kinase; Region: thiL; TIGR01379 983544003435 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 983544003436 ATP binding site [chemical binding]; other site 983544003437 dimerization interface [polypeptide binding]; other site 983544003438 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 983544003439 PGAP1-like protein; Region: PGAP1; pfam07819 983544003440 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 983544003441 Helix-turn-helix domain; Region: HTH_18; pfam12833 983544003442 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983544003443 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 983544003444 Uncharacterized conserved protein [Function unknown]; Region: COG2128 983544003445 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 983544003446 aspartate kinase III; Validated; Region: PRK09084 983544003447 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 983544003448 nucleotide binding site [chemical binding]; other site 983544003449 substrate binding site [chemical binding]; other site 983544003450 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 983544003451 dimer interface [polypeptide binding]; other site 983544003452 allosteric regulatory binding pocket; other site 983544003453 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 983544003454 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 983544003455 proline aminopeptidase P II; Provisional; Region: PRK10879 983544003456 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 983544003457 active site 983544003458 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 983544003459 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 983544003460 putative Iron-sulfur protein interface [polypeptide binding]; other site 983544003461 proximal heme binding site [chemical binding]; other site 983544003462 distal heme binding site [chemical binding]; other site 983544003463 putative dimer interface [polypeptide binding]; other site 983544003464 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 983544003465 L-aspartate oxidase; Provisional; Region: PRK06175 983544003466 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 983544003467 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 983544003468 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 983544003469 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 983544003470 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 983544003471 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983544003472 Walker A/P-loop; other site 983544003473 ATP binding site [chemical binding]; other site 983544003474 Q-loop/lid; other site 983544003475 ABC transporter signature motif; other site 983544003476 Walker B; other site 983544003477 D-loop; other site 983544003478 H-loop/switch region; other site 983544003479 Histidine kinase; Region: His_kinase; pfam06580 983544003480 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 983544003481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544003482 active site 983544003483 phosphorylation site [posttranslational modification] 983544003484 intermolecular recognition site; other site 983544003485 dimerization interface [polypeptide binding]; other site 983544003486 LytTr DNA-binding domain; Region: LytTR; smart00850 983544003487 Peptidase S46; Region: Peptidase_S46; pfam10459 983544003488 methionine aminotransferase; Validated; Region: PRK09082 983544003489 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983544003490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544003491 homodimer interface [polypeptide binding]; other site 983544003492 catalytic residue [active] 983544003493 C-N hydrolase family amidase; Provisional; Region: PRK10438 983544003494 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 983544003495 putative active site [active] 983544003496 catalytic triad [active] 983544003497 dimer interface [polypeptide binding]; other site 983544003498 multimer interface [polypeptide binding]; other site 983544003499 Bacterial Ig-like domain; Region: Big_5; pfam13205 983544003500 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 983544003501 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 983544003502 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983544003503 active site 983544003504 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 983544003505 glycyl-tRNA synthetase; Provisional; Region: PRK04173 983544003506 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 983544003507 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 983544003508 motif 1; other site 983544003509 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 983544003510 motif 1; other site 983544003511 dimer interface [polypeptide binding]; other site 983544003512 active site 983544003513 motif 2; other site 983544003514 motif 3; other site 983544003515 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 983544003516 anticodon binding site; other site 983544003517 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268 983544003518 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 983544003519 putative active site [active] 983544003520 putative catalytic site [active] 983544003521 putative DNA binding site [nucleotide binding]; other site 983544003522 putative phosphate binding site [ion binding]; other site 983544003523 metal binding site A [ion binding]; metal-binding site 983544003524 putative AP binding site [nucleotide binding]; other site 983544003525 putative metal binding site B [ion binding]; other site 983544003526 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 983544003527 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 983544003528 active site 983544003529 catalytic tetrad [active] 983544003530 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 983544003531 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 983544003532 TPR repeat; Region: TPR_11; pfam13414 983544003533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544003534 TPR motif; other site 983544003535 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983544003536 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983544003537 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 983544003538 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983544003539 ligand binding site [chemical binding]; other site 983544003540 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 983544003541 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 983544003542 homodimer interface [polypeptide binding]; other site 983544003543 oligonucleotide binding site [chemical binding]; other site 983544003544 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 983544003545 IHF - DNA interface [nucleotide binding]; other site 983544003546 IHF dimer interface [polypeptide binding]; other site 983544003547 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 983544003548 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 983544003549 minor groove reading motif; other site 983544003550 helix-hairpin-helix signature motif; other site 983544003551 substrate binding pocket [chemical binding]; other site 983544003552 active site 983544003553 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 983544003554 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 983544003555 DNA binding and oxoG recognition site [nucleotide binding] 983544003556 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 983544003557 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 983544003558 dimer interface [polypeptide binding]; other site 983544003559 ssDNA binding site [nucleotide binding]; other site 983544003560 tetramer (dimer of dimers) interface [polypeptide binding]; other site 983544003561 Domain of unknown function DUF21; Region: DUF21; pfam01595 983544003562 gliding motility-associated protein GldE; Region: GldE; TIGR03520 983544003563 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 983544003564 Transporter associated domain; Region: CorC_HlyC; smart01091 983544003565 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 983544003566 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983544003567 metal-binding site [ion binding] 983544003568 EamA-like transporter family; Region: EamA; pfam00892 983544003569 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 983544003570 EamA-like transporter family; Region: EamA; pfam00892 983544003571 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 983544003572 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 983544003573 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 983544003574 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 983544003575 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 983544003576 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 983544003577 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 983544003578 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 983544003579 Uncharacterized conserved protein [Function unknown]; Region: COG3743 983544003580 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 983544003581 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 983544003582 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 983544003583 active site 983544003584 DNA binding site [nucleotide binding] 983544003585 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 983544003586 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 983544003587 Catalytic site [active] 983544003588 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 983544003589 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 983544003590 homotetramer interface [polypeptide binding]; other site 983544003591 ligand binding site [chemical binding]; other site 983544003592 catalytic site [active] 983544003593 NAD binding site [chemical binding]; other site 983544003594 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 983544003595 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 983544003596 geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169 983544003597 phosphate binding site [ion binding]; other site 983544003598 Domain of unknown function DUF77; Region: DUF77; cl00307 983544003599 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 983544003600 AAA domain; Region: AAA_28; pfam13521 983544003601 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 983544003602 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 983544003603 hypothetical protein; Provisional; Region: PRK09256 983544003604 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983544003605 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544003606 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 983544003607 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 983544003608 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 983544003609 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 983544003610 nucleotide binding site/active site [active] 983544003611 HIT family signature motif; other site 983544003612 catalytic residue [active] 983544003613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983544003614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983544003615 phosphorylation site [posttranslational modification] 983544003616 dimer interface [polypeptide binding]; other site 983544003617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544003618 ATP binding site [chemical binding]; other site 983544003619 Mg2+ binding site [ion binding]; other site 983544003620 G-X-G motif; other site 983544003621 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 983544003622 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 983544003623 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 983544003624 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 983544003625 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 983544003626 Thioredoxin (TRX) superfamily; a large, diverse group of proteins containing a TRX-fold. Many members contain a classic TRX domain with a redox active CXXC motif. They function as protein disulfide oxidoreductases (PDOs), altering the redox state of...; Region: TRX_superfamily; cd01659 983544003627 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 983544003628 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 983544003629 RNA binding site [nucleotide binding]; other site 983544003630 active site 983544003631 Bacitracin resistance protein BacA; Region: BacA; pfam02673 983544003632 SnoaL-like domain; Region: SnoaL_3; pfam13474 983544003633 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 983544003634 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 983544003635 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 983544003636 Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: LeuS; COG0495 983544003637 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983544003638 active site 983544003639 HIGH motif; other site 983544003640 nucleotide binding site [chemical binding]; other site 983544003641 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983544003642 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 983544003643 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983544003644 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983544003645 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983544003646 active site 983544003647 KMSKS motif; other site 983544003648 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 983544003649 tRNA binding surface [nucleotide binding]; other site 983544003650 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 983544003651 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 983544003652 Rhodococcus equi virulence-associated protein; Region: R_equi_Vir; pfam05526 983544003653 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983544003654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544003655 active site 983544003656 phosphorylation site [posttranslational modification] 983544003657 intermolecular recognition site; other site 983544003658 dimerization interface [polypeptide binding]; other site 983544003659 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983544003660 DNA binding residues [nucleotide binding] 983544003661 dimerization interface [polypeptide binding]; other site 983544003662 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 983544003663 Histidine kinase; Region: HisKA_3; pfam07730 983544003664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544003665 ATP binding site [chemical binding]; other site 983544003666 Mg2+ binding site [ion binding]; other site 983544003667 G-X-G motif; other site 983544003668 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 983544003669 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 983544003670 Phage Tail Collar Domain; Region: Collar; pfam07484 983544003671 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544003672 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 983544003673 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983544003674 putative DNA binding site [nucleotide binding]; other site 983544003675 putative Zn2+ binding site [ion binding]; other site 983544003676 AsnC family; Region: AsnC_trans_reg; pfam01037 983544003677 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 983544003678 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 983544003679 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 983544003680 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 983544003681 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 983544003682 active site 983544003683 substrate-binding site [chemical binding]; other site 983544003684 metal-binding site [ion binding] 983544003685 ATP binding site [chemical binding]; other site 983544003686 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 983544003687 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 983544003688 active site 983544003689 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 983544003690 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 983544003691 Putative Catalytic site; other site 983544003692 DXD motif; other site 983544003693 dihydroorotase; Reviewed; Region: PRK09236 983544003694 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983544003695 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 983544003696 active site 983544003697 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 983544003698 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 983544003699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983544003700 NAD(P) binding site [chemical binding]; other site 983544003701 active site 983544003702 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 983544003703 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 983544003704 active site 983544003705 HIGH motif; other site 983544003706 dimer interface [polypeptide binding]; other site 983544003707 KMSKS motif; other site 983544003708 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 983544003709 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 983544003710 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544003711 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544003712 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983544003713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544003714 active site 983544003715 phosphorylation site [posttranslational modification] 983544003716 intermolecular recognition site; other site 983544003717 dimerization interface [polypeptide binding]; other site 983544003718 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983544003719 DNA binding site [nucleotide binding] 983544003720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983544003721 dimer interface [polypeptide binding]; other site 983544003722 phosphorylation site [posttranslational modification] 983544003723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544003724 ATP binding site [chemical binding]; other site 983544003725 Mg2+ binding site [ion binding]; other site 983544003726 G-X-G motif; other site 983544003727 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 983544003728 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 983544003729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544003730 S-adenosylmethionine binding site [chemical binding]; other site 983544003731 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 983544003732 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 983544003733 DNA binding site [nucleotide binding] 983544003734 active site 983544003735 Domain of unknown function DUF59; Region: DUF59; pfam01883 983544003736 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 983544003737 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 983544003738 NifU-like domain; Region: NifU; cl00484 983544003739 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 983544003740 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 983544003741 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983544003742 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 983544003743 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 983544003744 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 983544003745 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 983544003746 putative active site [active] 983544003747 putative metal binding site [ion binding]; other site 983544003748 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 983544003749 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983544003750 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983544003751 active site 983544003752 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 983544003753 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 983544003754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544003755 S-adenosylmethionine binding site [chemical binding]; other site 983544003756 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 983544003757 RimM N-terminal domain; Region: RimM; pfam01782 983544003758 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 983544003759 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 983544003760 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 983544003761 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 983544003762 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 983544003763 active site 983544003764 catalytic site [active] 983544003765 substrate binding site [chemical binding]; other site 983544003766 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 983544003767 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 983544003768 active site 983544003769 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 983544003770 generic binding surface II; other site 983544003771 generic binding surface I; other site 983544003772 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 983544003773 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 983544003774 catalytic residues [active] 983544003775 Clp protease; Region: CLP_protease; pfam00574 983544003776 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 983544003777 oligomer interface [polypeptide binding]; other site 983544003778 active site residues [active] 983544003779 Protein of unknown function DUF58; Region: DUF58; pfam01882 983544003780 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983544003781 Histidine kinase; Region: HisKA_3; pfam07730 983544003782 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 983544003783 ATP binding site [chemical binding]; other site 983544003784 Mg2+ binding site [ion binding]; other site 983544003785 G-X-G motif; other site 983544003786 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983544003787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544003788 active site 983544003789 phosphorylation site [posttranslational modification] 983544003790 intermolecular recognition site; other site 983544003791 dimerization interface [polypeptide binding]; other site 983544003792 Protein of unknown function (DUF456); Region: DUF456; pfam04306 983544003793 Penicillinase repressor; Region: Pencillinase_R; pfam03965 983544003794 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 983544003795 Gram-negative bacterial tonB protein; Region: TonB; cl10048 983544003796 Bax inhibitor 1 like; Region: BaxI_1; cl17691 983544003797 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 983544003798 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_e; cd04192 983544003799 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 983544003800 active site 983544003801 putative DNA-binding cleft [nucleotide binding]; other site 983544003802 dimer interface [polypeptide binding]; other site 983544003803 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 983544003804 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983544003805 FeS/SAM binding site; other site 983544003806 HemN C-terminal domain; Region: HemN_C; pfam06969 983544003807 Putative cyclase; Region: Cyclase; pfam04199 983544003808 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 983544003809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 983544003810 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983544003811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544003812 intermolecular recognition site; other site 983544003813 active site 983544003814 dimerization interface [polypeptide binding]; other site 983544003815 Heme NO binding; Region: HNOB; pfam07700 983544003816 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544003817 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 983544003818 putative active site [active] 983544003819 heme pocket [chemical binding]; other site 983544003820 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544003821 putative active site [active] 983544003822 heme pocket [chemical binding]; other site 983544003823 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983544003824 dimer interface [polypeptide binding]; other site 983544003825 phosphorylation site [posttranslational modification] 983544003826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544003827 ATP binding site [chemical binding]; other site 983544003828 Mg2+ binding site [ion binding]; other site 983544003829 G-X-G motif; other site 983544003830 FIST N domain; Region: FIST; pfam08495 983544003831 FIST C domain; Region: FIST_C; pfam10442 983544003832 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983544003833 dimer interface [polypeptide binding]; other site 983544003834 phosphorylation site [posttranslational modification] 983544003835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544003836 ATP binding site [chemical binding]; other site 983544003837 Mg2+ binding site [ion binding]; other site 983544003838 G-X-G motif; other site 983544003839 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 983544003840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544003841 active site 983544003842 phosphorylation site [posttranslational modification] 983544003843 intermolecular recognition site; other site 983544003844 dimerization interface [polypeptide binding]; other site 983544003845 LytTr DNA-binding domain; Region: LytTR; smart00850 983544003846 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 983544003847 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544003848 Tetratricopeptide repeat; Region: TPR_16; pfam13432 983544003849 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544003850 binding surface 983544003851 TPR motif; other site 983544003852 TPR repeat; Region: TPR_11; pfam13414 983544003853 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544003854 binding surface 983544003855 TPR motif; other site 983544003856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983544003857 TPR motif; other site 983544003858 binding surface 983544003859 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 983544003860 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983544003861 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983544003862 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 983544003863 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 983544003864 Predicted integral membrane protein [Function unknown]; Region: COG5617 983544003865 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 983544003866 Response regulator receiver domain; Region: Response_reg; pfam00072 983544003867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544003868 active site 983544003869 phosphorylation site [posttranslational modification] 983544003870 intermolecular recognition site; other site 983544003871 dimerization interface [polypeptide binding]; other site 983544003872 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 983544003873 Ligand binding site; other site 983544003874 Ligand binding site; other site 983544003875 Ligand binding site; other site 983544003876 Putative Catalytic site; other site 983544003877 DXD motif; other site 983544003878 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 983544003879 active site 983544003880 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 983544003881 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 983544003882 ligand binding site [chemical binding]; other site 983544003883 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 983544003884 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 983544003885 PhnA protein; Region: PhnA; pfam03831 983544003886 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 983544003887 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 983544003888 GldM C-terminal domain; Region: GldM_C; pfam12080 983544003889 Penicillinase repressor; Region: Pencillinase_R; pfam03965 983544003890 hypothetical protein; Provisional; Region: PRK08201 983544003891 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 983544003892 metal binding site [ion binding]; metal-binding site 983544003893 putative dimer interface [polypeptide binding]; other site 983544003894 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983544003895 Ligand Binding Site [chemical binding]; other site 983544003896 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983544003897 Ligand Binding Site [chemical binding]; other site 983544003898 hypothetical protein; Validated; Region: PRK02001 983544003899 ribosome maturation protein RimP; Reviewed; Region: PRK00092 983544003900 heptamer interface [polypeptide binding]; other site 983544003901 Sm1 motif; other site 983544003902 hexamer interface [polypeptide binding]; other site 983544003903 RNA binding site [nucleotide binding]; other site 983544003904 Sm2 motif; other site 983544003905 transcription termination factor NusA; Region: NusA; TIGR01953 983544003906 NusA N-terminal domain; Region: NusA_N; pfam08529 983544003907 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 983544003908 RNA binding site [nucleotide binding]; other site 983544003909 homodimer interface [polypeptide binding]; other site 983544003910 NusA-like KH domain; Region: KH_5; pfam13184 983544003911 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 983544003912 G-X-X-G motif; other site 983544003913 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 983544003914 translation initiation factor IF-2; Region: IF-2; TIGR00487 983544003915 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 983544003916 G1 box; other site 983544003917 putative GEF interaction site [polypeptide binding]; other site 983544003918 GTP/Mg2+ binding site [chemical binding]; other site 983544003919 Switch I region; other site 983544003920 G2 box; other site 983544003921 G3 box; other site 983544003922 Switch II region; other site 983544003923 G4 box; other site 983544003924 G5 box; other site 983544003925 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 983544003926 Translation-initiation factor 2; Region: IF-2; pfam11987 983544003927 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 983544003928 Sporulation related domain; Region: SPOR; cl10051 983544003929 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 983544003930 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 983544003931 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 983544003932 heme-binding residues [chemical binding]; other site 983544003933 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 983544003934 molybdopterin cofactor binding site; other site 983544003935 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 983544003936 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 983544003937 4Fe-4S binding domain; Region: Fer4; cl02805 983544003938 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 983544003939 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 983544003940 Uncharacterized conserved protein [Function unknown]; Region: COG3743 983544003941 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 983544003942 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 983544003943 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 983544003944 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 983544003945 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 983544003946 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 983544003947 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 983544003948 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 983544003949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983544003950 Walker A motif; other site 983544003951 ATP binding site [chemical binding]; other site 983544003952 Walker B motif; other site 983544003953 arginine finger; other site 983544003954 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 983544003955 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 983544003956 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 983544003957 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 983544003958 Malic enzyme, N-terminal domain; Region: malic; pfam00390 983544003959 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 983544003960 putative NAD(P) binding site [chemical binding]; other site 983544003961 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 983544003962 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 983544003963 RuvA N terminal domain; Region: RuvA_N; pfam01330 983544003964 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 983544003965 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 983544003966 cell surface protein SprA; Region: surface_SprA; TIGR04189 983544003967 Motility related/secretion protein; Region: SprA_N; pfam14349 983544003968 Motility related/secretion protein; Region: SprA_N; pfam14349 983544003969 Motility related/secretion protein; Region: SprA_N; pfam14349 983544003970 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 983544003971 lipoyl attachment site [posttranslational modification]; other site 983544003972 Predicted integral membrane protein [Function unknown]; Region: COG5652 983544003973 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 983544003974 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 983544003975 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 983544003976 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 983544003977 UbiA prenyltransferase family; Region: UbiA; pfam01040 983544003978 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 983544003979 Subunit I/III interface [polypeptide binding]; other site 983544003980 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 983544003981 Subunit I/III interface [polypeptide binding]; other site 983544003982 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 983544003983 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 983544003984 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 983544003985 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 983544003986 Cu(I) binding site [ion binding]; other site 983544003987 Protein of unknown function (DUF420); Region: DUF420; pfam04238 983544003988 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 983544003989 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 983544003990 Walker A/P-loop; other site 983544003991 ATP binding site [chemical binding]; other site 983544003992 Q-loop/lid; other site 983544003993 ABC transporter signature motif; other site 983544003994 Walker B; other site 983544003995 D-loop; other site 983544003996 H-loop/switch region; other site 983544003997 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983544003998 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 983544003999 FtsX-like permease family; Region: FtsX; pfam02687 983544004000 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983544004001 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 983544004002 FtsX-like permease family; Region: FtsX; pfam02687 983544004003 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 983544004004 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 983544004005 HlyD family secretion protein; Region: HlyD_3; pfam13437 983544004006 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 983544004007 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 983544004008 Glycoprotease family; Region: Peptidase_M22; pfam00814 983544004009 Conserved TM helix; Region: TM_helix; pfam05552 983544004010 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983544004011 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 983544004012 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 983544004013 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 983544004014 catalytic residues [active] 983544004015 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 983544004016 active site 983544004017 zinc binding site [ion binding]; other site 983544004018 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041 983544004019 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 983544004020 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 983544004021 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 983544004022 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 983544004023 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 983544004024 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544004025 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983544004026 Histidine kinase; Region: His_kinase; pfam06580 983544004027 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 983544004028 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 983544004029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544004030 active site 983544004031 phosphorylation site [posttranslational modification] 983544004032 intermolecular recognition site; other site 983544004033 dimerization interface [polypeptide binding]; other site 983544004034 LytTr DNA-binding domain; Region: LytTR; smart00850 983544004035 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 983544004036 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 983544004037 trimer interface [polypeptide binding]; other site 983544004038 putative metal binding site [ion binding]; other site 983544004039 glutamate racemase; Provisional; Region: PRK00865 983544004040 periplasmic chaperone; Provisional; Region: PRK10780 983544004041 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 983544004042 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 983544004043 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 983544004044 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 983544004045 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 983544004046 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 983544004047 Surface antigen; Region: Bac_surface_Ag; pfam01103 983544004048 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 983544004049 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 983544004050 catalytic residue [active] 983544004051 putative FPP diphosphate binding site; other site 983544004052 putative FPP binding hydrophobic cleft; other site 983544004053 dimer interface [polypeptide binding]; other site 983544004054 putative IPP diphosphate binding site; other site 983544004055 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 983544004056 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01911 983544004057 ATP-NAD kinase; Region: NAD_kinase; pfam01513 983544004058 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 983544004059 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 983544004060 active site 983544004061 hydrophilic channel; other site 983544004062 dimerization interface [polypeptide binding]; other site 983544004063 catalytic residues [active] 983544004064 active site lid [active] 983544004065 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 983544004066 acyl-CoA esterase; Provisional; Region: PRK10673 983544004067 PGAP1-like protein; Region: PGAP1; pfam07819 983544004068 Membrane protein of unknown function; Region: DUF360; pfam04020 983544004069 trigger factor; Region: tig; TIGR00115 983544004070 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 983544004071 Clp protease; Region: CLP_protease; pfam00574 983544004072 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 983544004073 oligomer interface [polypeptide binding]; other site 983544004074 active site residues [active] 983544004075 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 983544004076 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 983544004077 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 983544004078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983544004079 Walker A motif; other site 983544004080 ATP binding site [chemical binding]; other site 983544004081 Walker B motif; other site 983544004082 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 983544004083 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 983544004084 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983544004085 Coenzyme A binding pocket [chemical binding]; other site 983544004086 GH3 auxin-responsive promoter; Region: GH3; pfam03321 983544004087 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 983544004088 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 983544004089 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 983544004090 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 983544004091 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 983544004092 catalytic center binding site [active] 983544004093 ATP binding site [chemical binding]; other site 983544004094 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 983544004095 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 983544004096 Substrate-binding site [chemical binding]; other site 983544004097 Substrate specificity [chemical binding]; other site 983544004098 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 983544004099 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 983544004100 MutS domain I; Region: MutS_I; pfam01624 983544004101 MutS domain II; Region: MutS_II; pfam05188 983544004102 MutS domain III; Region: MutS_III; pfam05192 983544004103 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 983544004104 Walker A/P-loop; other site 983544004105 ATP binding site [chemical binding]; other site 983544004106 Q-loop/lid; other site 983544004107 ABC transporter signature motif; other site 983544004108 Walker B; other site 983544004109 D-loop; other site 983544004110 H-loop/switch region; other site 983544004111 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 983544004112 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983544004113 active site 983544004114 HIGH motif; other site 983544004115 nucleotide binding site [chemical binding]; other site 983544004116 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 983544004117 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 983544004118 active site 983544004119 KMSKS motif; other site 983544004120 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 983544004121 tRNA binding surface [nucleotide binding]; other site 983544004122 anticodon binding site; other site 983544004123 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 983544004124 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 983544004125 Aspartyl protease; Region: Asp_protease_2; pfam13650 983544004126 Aspartyl protease; Region: Asp_protease_2; pfam13650 983544004127 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 983544004128 aspartate aminotransferase; Provisional; Region: PRK07568 983544004129 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983544004130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544004131 homodimer interface [polypeptide binding]; other site 983544004132 catalytic residue [active] 983544004133 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 983544004134 FAD binding domain; Region: FAD_binding_4; pfam01565 983544004135 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 983544004136 putative RNA polymerase sigma E protein; Provisional; Region: PRK13919 983544004137 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544004138 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983544004139 DNA binding residues [nucleotide binding] 983544004140 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 983544004141 amphipathic channel; other site 983544004142 Asn-Pro-Ala signature motifs; other site 983544004143 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 983544004144 active site 983544004145 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544004146 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983544004147 lipoyl synthase; Provisional; Region: PRK05481 983544004148 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983544004149 FeS/SAM binding site; other site 983544004150 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 983544004151 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 983544004152 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 983544004153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544004154 binding surface 983544004155 TPR motif; other site 983544004156 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983544004157 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983544004158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983544004159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983544004160 dimer interface [polypeptide binding]; other site 983544004161 phosphorylation site [posttranslational modification] 983544004162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544004163 ATP binding site [chemical binding]; other site 983544004164 Mg2+ binding site [ion binding]; other site 983544004165 G-X-G motif; other site 983544004166 Response regulator receiver domain; Region: Response_reg; pfam00072 983544004167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544004168 active site 983544004169 phosphorylation site [posttranslational modification] 983544004170 intermolecular recognition site; other site 983544004171 dimerization interface [polypeptide binding]; other site 983544004172 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 983544004173 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 983544004174 Uncharacterized conserved protein [Function unknown]; Region: COG0327 983544004175 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 983544004176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 983544004177 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 983544004178 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 983544004179 Putative zinc ribbon domain; Region: DUF164; pfam02591 983544004180 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 983544004181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544004182 S-adenosylmethionine binding site [chemical binding]; other site 983544004183 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983544004184 kynureninase; Region: kynureninase; TIGR01814 983544004185 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983544004186 catalytic residue [active] 983544004187 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 983544004188 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 983544004189 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 983544004190 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 983544004191 homotrimer interaction site [polypeptide binding]; other site 983544004192 putative active site [active] 983544004193 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983544004194 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 983544004195 NAD binding site [chemical binding]; other site 983544004196 catalytic residues [active] 983544004197 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 983544004198 GIY-YIG motif/motif A; other site 983544004199 putative active site [active] 983544004200 putative metal binding site [ion binding]; other site 983544004201 short chain dehydrogenase; Provisional; Region: PRK08339 983544004202 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 983544004203 putative NAD(P) binding site [chemical binding]; other site 983544004204 putative active site [active] 983544004205 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 983544004206 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983544004207 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 983544004208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544004209 S-adenosylmethionine binding site [chemical binding]; other site 983544004210 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 983544004211 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 983544004212 CAAX protease self-immunity; Region: Abi; pfam02517 983544004213 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 983544004214 active site 983544004215 catalytic residues [active] 983544004216 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 983544004217 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 983544004218 dimer interface [polypeptide binding]; other site 983544004219 substrate binding site [chemical binding]; other site 983544004220 metal binding sites [ion binding]; metal-binding site 983544004221 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 983544004222 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 983544004223 active site 983544004224 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 983544004225 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544004226 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983544004227 DNA binding residues [nucleotide binding] 983544004228 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 983544004229 FecR protein; Region: FecR; pfam04773 983544004230 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544004231 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544004232 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983544004233 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544004234 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 983544004235 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 983544004236 alpha subunit interface [polypeptide binding]; other site 983544004237 TPP binding site [chemical binding]; other site 983544004238 heterodimer interface [polypeptide binding]; other site 983544004239 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 983544004240 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 983544004241 Ligand binding site [chemical binding]; other site 983544004242 Electron transfer flavoprotein domain; Region: ETF; pfam01012 983544004243 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 983544004244 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 983544004245 Ligand Binding Site [chemical binding]; other site 983544004246 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 983544004247 Bifunctional nuclease; Region: DNase-RNase; pfam02577 983544004248 UvrB/uvrC motif; Region: UVR; pfam02151 983544004249 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 983544004250 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 983544004251 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 983544004252 Nucleoside recognition; Region: Gate; pfam07670 983544004253 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 983544004254 thymidylate synthase; Reviewed; Region: thyA; PRK01827 983544004255 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 983544004256 dimerization interface [polypeptide binding]; other site 983544004257 active site 983544004258 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 983544004259 2TM domain; Region: 2TM; pfam13239 983544004260 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 983544004261 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 983544004262 folate binding site [chemical binding]; other site 983544004263 NADP+ binding site [chemical binding]; other site 983544004264 Methyltransferase domain; Region: Methyltransf_24; pfam13578 983544004265 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 983544004266 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 983544004267 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 983544004268 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 983544004269 lipoprotein signal peptidase; Provisional; Region: PRK14787 983544004270 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 983544004271 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983544004272 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 983544004273 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 983544004274 active site 983544004275 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 983544004276 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 983544004277 NAD binding site [chemical binding]; other site 983544004278 homodimer interface [polypeptide binding]; other site 983544004279 active site 983544004280 substrate binding site [chemical binding]; other site 983544004281 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 983544004282 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 983544004283 inhibitor-cofactor binding pocket; inhibition site 983544004284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544004285 catalytic residue [active] 983544004286 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 983544004287 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 983544004288 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 983544004289 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 983544004290 active site 983544004291 substrate binding site [chemical binding]; other site 983544004292 Mg2+ binding site [ion binding]; other site 983544004293 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 983544004294 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 983544004295 DXD motif; other site 983544004296 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 983544004297 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 983544004298 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 983544004299 dimer interface [polypeptide binding]; other site 983544004300 active site 983544004301 CoA binding pocket [chemical binding]; other site 983544004302 glycine dehydrogenase; Provisional; Region: PRK05367 983544004303 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 983544004304 tetramer interface [polypeptide binding]; other site 983544004305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544004306 catalytic residue [active] 983544004307 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 983544004308 tetramer interface [polypeptide binding]; other site 983544004309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544004310 catalytic residue [active] 983544004311 RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1 983544004312 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544004313 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983544004314 DNA binding residues [nucleotide binding] 983544004315 Methyltransferase domain; Region: Methyltransf_11; pfam08241 983544004316 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 983544004317 DoxX-like family; Region: DoxX_3; pfam13781 983544004318 Predicted transcriptional regulators [Transcription]; Region: COG1510 983544004319 MarR family; Region: MarR_2; pfam12802 983544004320 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 983544004321 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 983544004322 active site 983544004323 Zn binding site [ion binding]; other site 983544004324 AIR carboxylase; Region: AIRC; pfam00731 983544004325 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 983544004326 ATP-grasp domain; Region: ATP-grasp; pfam02222 983544004327 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983544004328 active site 983544004329 adenylate kinase; Reviewed; Region: adk; PRK00279 983544004330 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 983544004331 AMP-binding site [chemical binding]; other site 983544004332 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 983544004333 GTPase CgtA; Reviewed; Region: obgE; PRK12299 983544004334 GTP1/OBG; Region: GTP1_OBG; pfam01018 983544004335 Obg GTPase; Region: Obg; cd01898 983544004336 G1 box; other site 983544004337 GTP/Mg2+ binding site [chemical binding]; other site 983544004338 Switch I region; other site 983544004339 G2 box; other site 983544004340 G3 box; other site 983544004341 Switch II region; other site 983544004342 G4 box; other site 983544004343 G5 box; other site 983544004344 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 983544004345 MG2 domain; Region: A2M_N; pfam01835 983544004346 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 983544004347 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 983544004348 Alpha-2-macroglobulin family; Region: A2M; pfam00207 983544004349 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 983544004350 Tetratricopeptide repeat; Region: TPR_16; pfam13432 983544004351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983544004352 TPR motif; other site 983544004353 binding surface 983544004354 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 983544004355 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 983544004356 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983544004357 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983544004358 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 983544004359 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 983544004360 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 983544004361 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 983544004362 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 983544004363 rod shape-determining protein MreC; Provisional; Region: PRK13922 983544004364 rod shape-determining protein MreC; Region: MreC; pfam04085 983544004365 rod shape-determining protein MreB; Provisional; Region: PRK13927 983544004366 MreB and similar proteins; Region: MreB_like; cd10225 983544004367 nucleotide binding site [chemical binding]; other site 983544004368 Mg binding site [ion binding]; other site 983544004369 putative protofilament interaction site [polypeptide binding]; other site 983544004370 RodZ interaction site [polypeptide binding]; other site 983544004371 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 983544004372 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 983544004373 purine monophosphate binding site [chemical binding]; other site 983544004374 dimer interface [polypeptide binding]; other site 983544004375 putative catalytic residues [active] 983544004376 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 983544004377 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 983544004378 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 983544004379 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 983544004380 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 983544004381 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 983544004382 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983544004383 metal-binding site [ion binding] 983544004384 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544004385 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983544004386 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544004387 Heavy-metal-associated domain; Region: HMA; pfam00403 983544004388 metal-binding site [ion binding] 983544004389 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 983544004390 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 983544004391 ring oligomerisation interface [polypeptide binding]; other site 983544004392 ATP/Mg binding site [chemical binding]; other site 983544004393 stacking interactions; other site 983544004394 hinge regions; other site 983544004395 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 983544004396 oligomerisation interface [polypeptide binding]; other site 983544004397 mobile loop; other site 983544004398 roof hairpin; other site 983544004399 Tetratricopeptide repeat; Region: TPR_6; pfam13174 983544004400 Lipopolysaccharide-assembly; Region: LptE; pfam04390 983544004401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983544004402 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 983544004403 Walker A motif; other site 983544004404 ATP binding site [chemical binding]; other site 983544004405 Walker B motif; other site 983544004406 arginine finger; other site 983544004407 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 983544004408 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 983544004409 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 983544004410 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 983544004411 FeS/SAM binding site; other site 983544004412 TRAM domain; Region: TRAM; pfam01938 983544004413 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 983544004414 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 983544004415 active site 983544004416 interdomain interaction site; other site 983544004417 putative metal-binding site [ion binding]; other site 983544004418 nucleotide binding site [chemical binding]; other site 983544004419 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 983544004420 domain I; other site 983544004421 DNA binding groove [nucleotide binding] 983544004422 phosphate binding site [ion binding]; other site 983544004423 domain II; other site 983544004424 domain III; other site 983544004425 nucleotide binding site [chemical binding]; other site 983544004426 catalytic site [active] 983544004427 domain IV; other site 983544004428 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 983544004429 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 983544004430 putative active site [active] 983544004431 putative metal binding site [ion binding]; other site 983544004432 gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525 983544004433 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 983544004434 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 983544004435 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 983544004436 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 983544004437 GldM N-terminal domain; Region: GldM_N; pfam12081 983544004438 GldM C-terminal domain; Region: GldM_C; pfam12080 983544004439 gliding motility associated protien GldN; Region: GldN; TIGR03523 983544004440 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 983544004441 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 983544004442 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 983544004443 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983544004444 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983544004445 ABC transporter; Region: ABC_tran_2; pfam12848 983544004446 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983544004447 HlyD family secretion protein; Region: HlyD_2; pfam12700 983544004448 HlyD family secretion protein; Region: HlyD_3; pfam13437 983544004449 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983544004450 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 983544004451 Leucine rich repeat; Region: LRR_8; pfam13855 983544004452 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 983544004453 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 983544004454 active site 983544004455 catalytic residues [active] 983544004456 DNA binding site [nucleotide binding] 983544004457 Int/Topo IB signature motif; other site 983544004458 AAA domain; Region: AAA_25; pfam13481 983544004459 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 983544004460 Walker A motif; other site 983544004461 ATP binding site [chemical binding]; other site 983544004462 Walker B motif; other site 983544004463 Homeodomain-like domain; Region: HTH_23; pfam13384 983544004464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 983544004465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 983544004466 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 983544004467 Transposase; Region: DEDD_Tnp_IS110; pfam01548 983544004468 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 983544004469 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 983544004470 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 983544004471 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 983544004472 active site 983544004473 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 983544004474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544004475 ATP binding site [chemical binding]; other site 983544004476 Mg2+ binding site [ion binding]; other site 983544004477 G-X-G motif; other site 983544004478 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 983544004479 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 983544004480 active site 983544004481 PHP Thumb interface [polypeptide binding]; other site 983544004482 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 983544004483 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 983544004484 active site 983544004485 DNA binding site [nucleotide binding] 983544004486 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 983544004487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983544004488 non-specific DNA binding site [nucleotide binding]; other site 983544004489 salt bridge; other site 983544004490 sequence-specific DNA binding site [nucleotide binding]; other site 983544004491 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 983544004492 Catalytic site [active] 983544004493 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 983544004494 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cd12213 983544004495 ligand binding site [chemical binding]; other site 983544004496 Glycerate kinase family; Region: Gly_kinase; cl00841 983544004497 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 983544004498 putative transporter; Provisional; Region: PRK10484 983544004499 Na binding site [ion binding]; other site 983544004500 Trehalase; Region: Trehalase; cl17346 983544004501 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544004502 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983544004503 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544004504 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983544004505 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983544004506 DNA binding site [nucleotide binding] 983544004507 domain linker motif; other site 983544004508 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 983544004509 dimerization interface [polypeptide binding]; other site 983544004510 ligand binding site [chemical binding]; other site 983544004511 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983544004512 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983544004513 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 983544004514 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 983544004515 GTPase Era; Reviewed; Region: era; PRK00089 983544004516 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 983544004517 G1 box; other site 983544004518 GTP/Mg2+ binding site [chemical binding]; other site 983544004519 Switch I region; other site 983544004520 G2 box; other site 983544004521 Switch II region; other site 983544004522 G3 box; other site 983544004523 G4 box; other site 983544004524 G5 box; other site 983544004525 KH domain; Region: KH_2; pfam07650 983544004526 Uncharacterized conserved protein [Function unknown]; Region: COG3391 983544004527 GTP-binding protein Der; Reviewed; Region: PRK00093 983544004528 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 983544004529 G1 box; other site 983544004530 GTP/Mg2+ binding site [chemical binding]; other site 983544004531 Switch I region; other site 983544004532 G2 box; other site 983544004533 Switch II region; other site 983544004534 G3 box; other site 983544004535 G4 box; other site 983544004536 G5 box; other site 983544004537 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 983544004538 G1 box; other site 983544004539 GTP/Mg2+ binding site [chemical binding]; other site 983544004540 Switch I region; other site 983544004541 G2 box; other site 983544004542 G3 box; other site 983544004543 Switch II region; other site 983544004544 G4 box; other site 983544004545 G5 box; other site 983544004546 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 983544004547 ligand binding surface [chemical binding]; other site 983544004548 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 983544004549 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544004550 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544004551 Repair protein; Region: Repair_PSII; pfam04536 983544004552 Repair protein; Region: Repair_PSII; pfam04536 983544004553 Repair protein; Region: Repair_PSII; pfam04536 983544004554 LemA family; Region: LemA; cl00742 983544004555 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 983544004556 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 983544004557 DNA binding residues [nucleotide binding] 983544004558 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 983544004559 Peptidase family M23; Region: Peptidase_M23; pfam01551 983544004560 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 983544004561 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 983544004562 motif 1; other site 983544004563 active site 983544004564 motif 2; other site 983544004565 motif 3; other site 983544004566 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 983544004567 GSCFA family; Region: GSCFA; pfam08885 983544004568 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 983544004569 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 983544004570 active site residue [active] 983544004571 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 983544004572 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 983544004573 cofactor binding site; other site 983544004574 metal binding site [ion binding]; metal-binding site 983544004575 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983544004576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983544004577 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 983544004578 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 983544004579 FAD binding pocket [chemical binding]; other site 983544004580 FAD binding motif [chemical binding]; other site 983544004581 phosphate binding motif [ion binding]; other site 983544004582 beta-alpha-beta structure motif; other site 983544004583 NAD(p) ribose binding residues [chemical binding]; other site 983544004584 NAD binding pocket [chemical binding]; other site 983544004585 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 983544004586 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983544004587 catalytic loop [active] 983544004588 iron binding site [ion binding]; other site 983544004589 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 983544004590 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 983544004591 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 983544004592 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 983544004593 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 983544004594 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 983544004595 enoyl-CoA hydratase; Provisional; Region: PRK08140 983544004596 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983544004597 substrate binding site [chemical binding]; other site 983544004598 oxyanion hole (OAH) forming residues; other site 983544004599 trimer interface [polypeptide binding]; other site 983544004600 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 983544004601 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 983544004602 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983544004603 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983544004604 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 983544004605 four helix bundle protein; Region: TIGR02436 983544004606 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 983544004607 CoenzymeA binding site [chemical binding]; other site 983544004608 subunit interaction site [polypeptide binding]; other site 983544004609 PHB binding site; other site 983544004610 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 983544004611 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983544004612 dimer interface [polypeptide binding]; other site 983544004613 active site 983544004614 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 983544004615 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 983544004616 substrate binding site [chemical binding]; other site 983544004617 dimer interface [polypeptide binding]; other site 983544004618 NADP binding site [chemical binding]; other site 983544004619 catalytic residues [active] 983544004620 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983544004621 active site 2 [active] 983544004622 active site 1 [active] 983544004623 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 983544004624 GIY-YIG motif/motif A; other site 983544004625 putative active site [active] 983544004626 putative metal binding site [ion binding]; other site 983544004627 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 983544004628 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983544004629 substrate binding site [chemical binding]; other site 983544004630 oxyanion hole (OAH) forming residues; other site 983544004631 trimer interface [polypeptide binding]; other site 983544004632 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 983544004633 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 983544004634 putative trimer interface [polypeptide binding]; other site 983544004635 putative metal binding site [ion binding]; other site 983544004636 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983544004637 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983544004638 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 983544004639 NAD(P) binding site [chemical binding]; other site 983544004640 catalytic residues [active] 983544004641 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 983544004642 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 983544004643 acyl-activating enzyme (AAE) consensus motif; other site 983544004644 AMP binding site [chemical binding]; other site 983544004645 active site 983544004646 CoA binding site [chemical binding]; other site 983544004647 choline dehydrogenase; Validated; Region: PRK02106 983544004648 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 983544004649 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983544004650 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983544004651 putative DNA binding site [nucleotide binding]; other site 983544004652 putative Zn2+ binding site [ion binding]; other site 983544004653 AsnC family; Region: AsnC_trans_reg; pfam01037 983544004654 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 983544004655 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983544004656 E3 interaction surface; other site 983544004657 lipoyl attachment site [posttranslational modification]; other site 983544004658 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 983544004659 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 983544004660 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 983544004661 homodimer interface [polypeptide binding]; other site 983544004662 substrate-cofactor binding pocket; other site 983544004663 catalytic residue [active] 983544004664 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 983544004665 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 983544004666 tetramer interface [polypeptide binding]; other site 983544004667 TPP-binding site [chemical binding]; other site 983544004668 heterodimer interface [polypeptide binding]; other site 983544004669 phosphorylation loop region [posttranslational modification] 983544004670 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 983544004671 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 983544004672 alpha subunit interface [polypeptide binding]; other site 983544004673 TPP binding site [chemical binding]; other site 983544004674 heterodimer interface [polypeptide binding]; other site 983544004675 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 983544004676 Ubiquitin-like proteins; Region: UBQ; cl00155 983544004677 charged pocket; other site 983544004678 hydrophobic patch; other site 983544004679 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 983544004680 ThiC-associated domain; Region: ThiC-associated; pfam13667 983544004681 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 983544004682 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 983544004683 thiamine phosphate binding site [chemical binding]; other site 983544004684 active site 983544004685 pyrophosphate binding site [ion binding]; other site 983544004686 hypothetical protein; Reviewed; Region: PRK12275 983544004687 four helix bundle protein; Region: TIGR02436 983544004688 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 983544004689 dimer interface [polypeptide binding]; other site 983544004690 substrate binding site [chemical binding]; other site 983544004691 ATP binding site [chemical binding]; other site 983544004692 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 983544004693 thiamine phosphate binding site [chemical binding]; other site 983544004694 active site 983544004695 pyrophosphate binding site [ion binding]; other site 983544004696 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 983544004697 ThiS interaction site; other site 983544004698 putative active site [active] 983544004699 tetramer interface [polypeptide binding]; other site 983544004700 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 983544004701 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983544004702 FeS/SAM binding site; other site 983544004703 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 983544004704 hypothetical protein; Validated; Region: PRK07411 983544004705 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 983544004706 ATP binding site [chemical binding]; other site 983544004707 substrate interface [chemical binding]; other site 983544004708 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 983544004709 active site residue [active] 983544004710 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 983544004711 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 983544004712 Catalytic site; other site 983544004713 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 983544004714 urocanate hydratase; Provisional; Region: PRK05414 983544004715 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 983544004716 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 983544004717 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983544004718 catalytic residue [active] 983544004719 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 983544004720 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 983544004721 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 983544004722 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 983544004723 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 983544004724 inhibitor-cofactor binding pocket; inhibition site 983544004725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544004726 catalytic residue [active] 983544004727 Nudix hydrolase homolog; Region: PLN02791 983544004728 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 983544004729 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 983544004730 dimer interface [polypeptide binding]; other site 983544004731 putative anticodon binding site; other site 983544004732 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 983544004733 motif 1; other site 983544004734 active site 983544004735 motif 2; other site 983544004736 motif 3; other site 983544004737 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 983544004738 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 983544004739 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 983544004740 Predicted membrane protein [Function unknown]; Region: COG4818 983544004741 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 983544004742 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 983544004743 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983544004744 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544004745 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983544004746 CHAT domain; Region: CHAT; pfam12770 983544004747 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 983544004748 RNA/DNA hybrid binding site [nucleotide binding]; other site 983544004749 active site 983544004750 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 983544004751 PIF1-like helicase; Region: PIF1; pfam05970 983544004752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983544004753 Walker A motif; other site 983544004754 ATP binding site [chemical binding]; other site 983544004755 Walker B motif; other site 983544004756 Family description; Region: UvrD_C_2; pfam13538 983544004757 HRDC domain; Region: HRDC; pfam00570 983544004758 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983544004759 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 983544004760 FAD binding site [chemical binding]; other site 983544004761 homotetramer interface [polypeptide binding]; other site 983544004762 substrate binding pocket [chemical binding]; other site 983544004763 catalytic base [active] 983544004764 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 983544004765 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 983544004766 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 983544004767 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 983544004768 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 983544004769 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 983544004770 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 983544004771 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 983544004772 Gram-negative bacterial tonB protein; Region: TonB; cl10048 983544004773 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 983544004774 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983544004775 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 983544004776 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 983544004777 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983544004778 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983544004779 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 983544004780 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 983544004781 active site 983544004782 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 983544004783 active site 983544004784 catalytic motif [active] 983544004785 Zn binding site [ion binding]; other site 983544004786 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 983544004787 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 983544004788 tetramer interface [polypeptide binding]; other site 983544004789 TPP-binding site [chemical binding]; other site 983544004790 heterodimer interface [polypeptide binding]; other site 983544004791 phosphorylation loop region [posttranslational modification] 983544004792 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983544004793 E3 interaction surface; other site 983544004794 lipoyl attachment site [posttranslational modification]; other site 983544004795 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 983544004796 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983544004797 E3 interaction surface; other site 983544004798 lipoyl attachment site [posttranslational modification]; other site 983544004799 e3 binding domain; Region: E3_binding; pfam02817 983544004800 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 983544004801 M28 Zn-Peptidase IAP aminopeptidase may contain PA domain insert; Region: M28_like_5; cd08021 983544004802 Peptidase family M28; Region: Peptidase_M28; pfam04389 983544004803 metal binding site [ion binding]; metal-binding site 983544004804 short chain dehydrogenase; Provisional; Region: PRK12828 983544004805 classical (c) SDRs; Region: SDR_c; cd05233 983544004806 NAD(P) binding site [chemical binding]; other site 983544004807 active site 983544004808 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 983544004809 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 983544004810 putative catalytic residue [active] 983544004811 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 983544004812 Amidinotransferase; Region: Amidinotransf; pfam02274 983544004813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983544004814 binding surface 983544004815 TPR motif; other site 983544004816 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544004817 binding surface 983544004818 TPR motif; other site 983544004819 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983544004820 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544004821 binding surface 983544004822 TPR motif; other site 983544004823 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983544004824 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983544004825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983544004826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544004827 ATP binding site [chemical binding]; other site 983544004828 Mg2+ binding site [ion binding]; other site 983544004829 G-X-G motif; other site 983544004830 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 983544004831 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 983544004832 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983544004833 active site 983544004834 HIGH motif; other site 983544004835 nucleotide binding site [chemical binding]; other site 983544004836 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 983544004837 KMSK motif region; other site 983544004838 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 983544004839 tRNA binding surface [nucleotide binding]; other site 983544004840 anticodon binding site; other site 983544004841 SprT homologues; Region: SprT; cl01182 983544004842 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 983544004843 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 983544004844 Substrate binding site; other site 983544004845 Domain of unknown function (DUF389); Region: DUF389; pfam04087 983544004846 Serpentine type 7TM GPCR receptor class ab chemoreceptor; Region: 7TM_GPCR_Srab; cl11607 983544004847 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 983544004848 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 983544004849 Walker A/P-loop; other site 983544004850 ATP binding site [chemical binding]; other site 983544004851 Q-loop/lid; other site 983544004852 ABC transporter signature motif; other site 983544004853 Walker B; other site 983544004854 D-loop; other site 983544004855 H-loop/switch region; other site 983544004856 Permease; Region: Permease; pfam02405 983544004857 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 983544004858 Uncharacterized conserved protein [Function unknown]; Region: COG3379 983544004859 Acyl CoA binding protein; Region: ACBP; pfam00887 983544004860 acyl-CoA binding pocket [chemical binding]; other site 983544004861 CoA binding site [chemical binding]; other site 983544004862 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 983544004863 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 983544004864 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 983544004865 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 983544004866 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 983544004867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983544004868 Walker A motif; other site 983544004869 ATP binding site [chemical binding]; other site 983544004870 Walker B motif; other site 983544004871 arginine finger; other site 983544004872 Peptidase family M41; Region: Peptidase_M41; pfam01434 983544004873 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 983544004874 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 983544004875 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 983544004876 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983544004877 active site 983544004878 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 983544004879 nudix motif; other site 983544004880 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544004881 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 983544004882 putative active site [active] 983544004883 Zn binding site [ion binding]; other site 983544004884 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 983544004885 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 983544004886 Sulfate transporter family; Region: Sulfate_transp; pfam00916 983544004887 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 983544004888 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 983544004889 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 983544004890 active site 983544004891 (T/H)XGH motif; other site 983544004892 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 983544004893 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 983544004894 ATP-grasp domain; Region: ATP-grasp_4; cl17255 983544004895 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 983544004896 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 983544004897 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 983544004898 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983544004899 RNA binding surface [nucleotide binding]; other site 983544004900 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 983544004901 active site 983544004902 hypothetical protein; Validated; Region: PRK02101 983544004903 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 983544004904 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 983544004905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983544004906 binding surface 983544004907 TPR motif; other site 983544004908 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 983544004909 putative active site [active] 983544004910 Beta-lactamase; Region: Beta-lactamase; pfam00144 983544004911 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 983544004912 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 983544004913 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 983544004914 ATP binding site [chemical binding]; other site 983544004915 Mg++ binding site [ion binding]; other site 983544004916 motif III; other site 983544004917 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983544004918 nucleotide binding region [chemical binding]; other site 983544004919 ATP-binding site [chemical binding]; other site 983544004920 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 983544004921 Cytochrome c; Region: Cytochrom_C; pfam00034 983544004922 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 983544004923 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 983544004924 active site 983544004925 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 983544004926 Protein of unknown function (DUF805); Region: DUF805; pfam05656 983544004927 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 983544004928 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 983544004929 substrate binding site [chemical binding]; other site 983544004930 active site 983544004931 catalytic residues [active] 983544004932 heterodimer interface [polypeptide binding]; other site 983544004933 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 983544004934 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 983544004935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544004936 catalytic residue [active] 983544004937 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 983544004938 active site 983544004939 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 983544004940 active site 983544004941 ribulose/triose binding site [chemical binding]; other site 983544004942 phosphate binding site [ion binding]; other site 983544004943 substrate (anthranilate) binding pocket [chemical binding]; other site 983544004944 product (indole) binding pocket [chemical binding]; other site 983544004945 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 983544004946 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 983544004947 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 983544004948 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 983544004949 Glutamine amidotransferase class-I; Region: GATase; pfam00117 983544004950 glutamine binding [chemical binding]; other site 983544004951 catalytic triad [active] 983544004952 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 983544004953 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 983544004954 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 983544004955 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 983544004956 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 983544004957 catalytic residues [active] 983544004958 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 983544004959 putative catalytic residue [active] 983544004960 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 983544004961 active site residue [active] 983544004962 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 983544004963 active site residue [active] 983544004964 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 983544004965 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983544004966 substrate binding pocket [chemical binding]; other site 983544004967 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 983544004968 Alginate lyase; Region: Alginate_lyase2; pfam08787 983544004969 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 983544004970 Alginate lyase; Region: Alginate_lyase2; pfam08787 983544004971 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 983544004972 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 983544004973 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 983544004974 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 983544004975 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544004976 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 983544004977 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 983544004978 starch binding outer membrane protein SusD; Region: SusD; cd08977 983544004979 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 983544004980 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 983544004981 Alginate lyase; Region: Alginate_lyase2; pfam08787 983544004982 Transcriptional regulators [Transcription]; Region: GntR; COG1802 983544004983 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983544004984 DNA-binding site [nucleotide binding]; DNA binding site 983544004985 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 983544004986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983544004987 D-galactonate transporter; Region: 2A0114; TIGR00893 983544004988 putative substrate translocation pore; other site 983544004989 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983544004990 classical (c) SDRs; Region: SDR_c; cd05233 983544004991 NAD(P) binding site [chemical binding]; other site 983544004992 active site 983544004993 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 983544004994 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 983544004995 substrate binding site [chemical binding]; other site 983544004996 ATP binding site [chemical binding]; other site 983544004997 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 983544004998 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 983544004999 active site 983544005000 intersubunit interface [polypeptide binding]; other site 983544005001 catalytic residue [active] 983544005002 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983544005003 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983544005004 DNA binding site [nucleotide binding] 983544005005 domain linker motif; other site 983544005006 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 983544005007 dimerization interface [polypeptide binding]; other site 983544005008 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 983544005009 EamA-like transporter family; Region: EamA; cl17759 983544005010 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 983544005011 putative transposase OrfB; Reviewed; Region: PHA02517 983544005012 Integrase core domain; Region: rve; pfam00665 983544005013 Integrase core domain; Region: rve_3; pfam13683 983544005014 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 983544005015 Transposase; Region: HTH_Tnp_1; cl17663 983544005016 Saccharopine Dehydrogenase like proteins; Region: SDH_like; cd05199 983544005017 active site 983544005018 ligand binding site [chemical binding]; other site 983544005019 NAD(P) binding site [chemical binding]; other site 983544005020 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 983544005021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983544005022 NAD(P) binding site [chemical binding]; other site 983544005023 active site 983544005024 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 983544005025 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 983544005026 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 983544005027 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 983544005028 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 983544005029 G1 box; other site 983544005030 putative GEF interaction site [polypeptide binding]; other site 983544005031 GTP/Mg2+ binding site [chemical binding]; other site 983544005032 Switch I region; other site 983544005033 G2 box; other site 983544005034 G3 box; other site 983544005035 Switch II region; other site 983544005036 G4 box; other site 983544005037 G5 box; other site 983544005038 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 983544005039 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 983544005040 Methyltransferase domain; Region: Methyltransf_23; pfam13489 983544005041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544005042 S-adenosylmethionine binding site [chemical binding]; other site 983544005043 Methyltransferase domain; Region: Methyltransf_31; pfam13847 983544005044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544005045 S-adenosylmethionine binding site [chemical binding]; other site 983544005046 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 983544005047 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 983544005048 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 983544005049 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 983544005050 Ligand binding site; other site 983544005051 Putative Catalytic site; other site 983544005052 DXD motif; other site 983544005053 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 983544005054 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 983544005055 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 983544005056 inhibitor-cofactor binding pocket; inhibition site 983544005057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544005058 catalytic residue [active] 983544005059 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 983544005060 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 983544005061 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983544005062 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 983544005063 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983544005064 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 983544005065 putative ADP-binding pocket [chemical binding]; other site 983544005066 WxcM-like, C-terminal; Region: FdtA; pfam05523 983544005067 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 983544005068 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983544005069 active site 983544005070 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 983544005071 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 983544005072 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 983544005073 Walker A/P-loop; other site 983544005074 ATP binding site [chemical binding]; other site 983544005075 Q-loop/lid; other site 983544005076 ABC transporter signature motif; other site 983544005077 Walker B; other site 983544005078 D-loop; other site 983544005079 H-loop/switch region; other site 983544005080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544005081 binding surface 983544005082 TPR motif; other site 983544005083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544005084 binding surface 983544005085 Tetratricopeptide repeat; Region: TPR_16; pfam13432 983544005086 TPR motif; other site 983544005087 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 983544005088 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 983544005089 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544005090 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 983544005091 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 983544005092 active site 983544005093 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 983544005094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544005095 S-adenosylmethionine binding site [chemical binding]; other site 983544005096 Flagellin N-methylase; Region: FliB; pfam03692 983544005097 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 983544005098 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 983544005099 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 983544005100 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983544005101 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 983544005102 FtsX-like permease family; Region: FtsX; pfam02687 983544005103 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 983544005104 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 983544005105 dimer interface [polypeptide binding]; other site 983544005106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544005107 catalytic residue [active] 983544005108 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 983544005109 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 983544005110 Ion channel; Region: Ion_trans_2; pfam07885 983544005111 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 983544005112 TrkA-N domain; Region: TrkA_N; pfam02254 983544005113 TrkA-C domain; Region: TrkA_C; pfam02080 983544005114 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 983544005115 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 983544005116 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 983544005117 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 983544005118 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983544005119 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983544005120 active site 983544005121 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544005122 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983544005123 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 983544005124 active site 983544005125 DNA binding site [nucleotide binding] 983544005126 Int/Topo IB signature motif; other site 983544005127 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 983544005128 30S subunit binding site; other site 983544005129 elongation factor Tu; Reviewed; Region: PRK12735 983544005130 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 983544005131 G1 box; other site 983544005132 GEF interaction site [polypeptide binding]; other site 983544005133 GTP/Mg2+ binding site [chemical binding]; other site 983544005134 Switch I region; other site 983544005135 G2 box; other site 983544005136 G3 box; other site 983544005137 Switch II region; other site 983544005138 G4 box; other site 983544005139 G5 box; other site 983544005140 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 983544005141 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 983544005142 Antibiotic Binding Site [chemical binding]; other site 983544005143 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 983544005144 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 983544005145 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 983544005146 putative homodimer interface [polypeptide binding]; other site 983544005147 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 983544005148 heterodimer interface [polypeptide binding]; other site 983544005149 homodimer interface [polypeptide binding]; other site 983544005150 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 983544005151 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 983544005152 23S rRNA interface [nucleotide binding]; other site 983544005153 L7/L12 interface [polypeptide binding]; other site 983544005154 putative thiostrepton binding site; other site 983544005155 L25 interface [polypeptide binding]; other site 983544005156 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 983544005157 mRNA/rRNA interface [nucleotide binding]; other site 983544005158 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 983544005159 23S rRNA interface [nucleotide binding]; other site 983544005160 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 983544005161 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 983544005162 core dimer interface [polypeptide binding]; other site 983544005163 peripheral dimer interface [polypeptide binding]; other site 983544005164 L10 interface [polypeptide binding]; other site 983544005165 L11 interface [polypeptide binding]; other site 983544005166 putative EF-Tu interaction site [polypeptide binding]; other site 983544005167 putative EF-G interaction site [polypeptide binding]; other site 983544005168 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 983544005169 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 983544005170 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 983544005171 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 983544005172 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 983544005173 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 983544005174 RPB3 interaction site [polypeptide binding]; other site 983544005175 RPB1 interaction site [polypeptide binding]; other site 983544005176 RPB11 interaction site [polypeptide binding]; other site 983544005177 RPB10 interaction site [polypeptide binding]; other site 983544005178 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 983544005179 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 983544005180 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 983544005181 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 983544005182 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 983544005183 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 983544005184 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 983544005185 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 983544005186 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 983544005187 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 983544005188 DNA binding site [nucleotide binding] 983544005189 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 983544005190 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 983544005191 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 983544005192 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 983544005193 G1 box; other site 983544005194 putative GEF interaction site [polypeptide binding]; other site 983544005195 GTP/Mg2+ binding site [chemical binding]; other site 983544005196 Switch I region; other site 983544005197 G2 box; other site 983544005198 G3 box; other site 983544005199 Switch II region; other site 983544005200 G4 box; other site 983544005201 G5 box; other site 983544005202 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 983544005203 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005204 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005205 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005206 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005207 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005208 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005209 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005210 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005211 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005212 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005213 potential frameshift: common BLAST hit: gi|113476972|ref|YP_723033.1| hemolysin-type calcium-binding protein 983544005214 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005215 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005216 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005217 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005218 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005219 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005220 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005221 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005222 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005223 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005224 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005225 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005226 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005227 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005228 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 983544005229 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 983544005230 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 983544005231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544005232 TPR motif; other site 983544005233 TPR repeat; Region: TPR_11; pfam13414 983544005234 binding surface 983544005235 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 983544005236 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 983544005237 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983544005238 ligand binding site [chemical binding]; other site 983544005239 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 983544005240 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 983544005241 active site 983544005242 metal binding site [ion binding]; metal-binding site 983544005243 nudix motif; other site 983544005244 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 983544005245 active site 983544005246 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 983544005247 Protein of unknown function (DUF819); Region: DUF819; cl02317 983544005248 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983544005249 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 983544005250 Predicted membrane protein [Function unknown]; Region: COG4270 983544005251 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 983544005252 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 983544005253 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 983544005254 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 983544005255 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 983544005256 Interdomain contacts; other site 983544005257 Cytokine receptor motif; other site 983544005258 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544005259 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983544005260 Amidohydrolase; Region: Amidohydro_4; pfam13147 983544005261 active site 983544005262 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983544005263 Amidohydrolase; Region: Amidohydro_4; pfam13147 983544005264 active site 983544005265 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 983544005266 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 983544005267 active site 983544005268 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 983544005269 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 983544005270 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 983544005271 metal binding site [ion binding]; metal-binding site 983544005272 dimer interface [polypeptide binding]; other site 983544005273 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 983544005274 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 983544005275 active site 983544005276 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 983544005277 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 983544005278 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 983544005279 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 983544005280 DHH family; Region: DHH; pfam01368 983544005281 DHHA1 domain; Region: DHHA1; pfam02272 983544005282 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 983544005283 active site 983544005284 multimer interface [polypeptide binding]; other site 983544005285 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 983544005286 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 983544005287 active site 983544005288 Zn binding site [ion binding]; other site 983544005289 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544005290 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 983544005291 DNA-binding site [nucleotide binding]; DNA binding site 983544005292 RNA-binding motif; other site 983544005293 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 983544005294 DNA-binding site [nucleotide binding]; DNA binding site 983544005295 RNA-binding motif; other site 983544005296 Protein of unknown function (DUF721); Region: DUF721; pfam05258 983544005297 recombination protein F; Reviewed; Region: recF; PRK00064 983544005298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983544005299 Walker A/P-loop; other site 983544005300 ATP binding site [chemical binding]; other site 983544005301 Q-loop/lid; other site 983544005302 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983544005303 ABC transporter signature motif; other site 983544005304 Walker B; other site 983544005305 D-loop; other site 983544005306 H-loop/switch region; other site 983544005307 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 983544005308 homopentamer interface [polypeptide binding]; other site 983544005309 active site 983544005310 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 983544005311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544005312 ATP binding site [chemical binding]; other site 983544005313 Mg2+ binding site [ion binding]; other site 983544005314 G-X-G motif; other site 983544005315 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 983544005316 ATP binding site [chemical binding]; other site 983544005317 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 983544005318 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 983544005319 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 983544005320 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 983544005321 putative catalytic site [active] 983544005322 putative metal binding site [ion binding]; other site 983544005323 putative phosphate binding site [ion binding]; other site 983544005324 WbqC-like protein family; Region: WbqC; pfam08889 983544005325 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 983544005326 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 983544005327 Catalytic site [active] 983544005328 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 983544005329 dihydrodipicolinate reductase; Provisional; Region: PRK00048 983544005330 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 983544005331 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 983544005332 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 983544005333 ParB-like nuclease domain; Region: ParBc; pfam02195 983544005334 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 983544005335 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 983544005336 P-loop; other site 983544005337 Magnesium ion binding site [ion binding]; other site 983544005338 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 983544005339 Magnesium ion binding site [ion binding]; other site 983544005340 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 983544005341 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 983544005342 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 983544005343 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 983544005344 CotH protein; Region: CotH; pfam08757 983544005345 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 983544005346 Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425 983544005347 active site 983544005348 metal binding site [ion binding]; metal-binding site 983544005349 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 983544005350 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 983544005351 active site 983544005352 substrate binding site [chemical binding]; other site 983544005353 coenzyme B12 binding site [chemical binding]; other site 983544005354 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 983544005355 B12 binding site [chemical binding]; other site 983544005356 cobalt ligand [ion binding]; other site 983544005357 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 983544005358 heterodimer interface [polypeptide binding]; other site 983544005359 substrate interaction site [chemical binding]; other site 983544005360 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 983544005361 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 983544005362 ATP-binding site [chemical binding]; other site 983544005363 Sugar specificity; other site 983544005364 Pyrimidine base specificity; other site 983544005365 Cytochrome c; Region: Cytochrom_C; pfam00034 983544005366 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 983544005367 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 983544005368 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 983544005369 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 983544005370 NAD(P) binding site [chemical binding]; other site 983544005371 catalytic residues [active] 983544005372 YtxH-like protein; Region: YtxH; cl02079 983544005373 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 983544005374 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 983544005375 active site 983544005376 DNA binding site [nucleotide binding] 983544005377 Int/Topo IB signature motif; other site 983544005378 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 983544005379 Helix-turn-helix domain; Region: HTH_18; pfam12833 983544005380 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983544005381 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983544005382 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983544005383 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983544005384 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 983544005385 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 983544005386 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983544005387 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 983544005388 PspC domain; Region: PspC; pfam04024 983544005389 Predicted transcriptional regulators [Transcription]; Region: COG1695 983544005390 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983544005391 putative Zn2+ binding site [ion binding]; other site 983544005392 putative DNA binding site [nucleotide binding]; other site 983544005393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 983544005394 Uncharacterized conserved protein [Function unknown]; Region: COG2013 983544005395 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 983544005396 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 983544005397 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 983544005398 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 983544005399 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983544005400 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 983544005401 dimerization interface [polypeptide binding]; other site 983544005402 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 983544005403 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 983544005404 dimerization interface [polypeptide binding]; other site 983544005405 DPS ferroxidase diiron center [ion binding]; other site 983544005406 ion pore; other site 983544005407 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 983544005408 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 983544005409 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983544005410 ligand binding site [chemical binding]; other site 983544005411 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 983544005412 Protein of unknown function DUF58; Region: DUF58; pfam01882 983544005413 MoxR-like ATPases [General function prediction only]; Region: COG0714 983544005414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983544005415 Walker A motif; other site 983544005416 ATP binding site [chemical binding]; other site 983544005417 Walker B motif; other site 983544005418 arginine finger; other site 983544005419 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 983544005420 Integral membrane protein DUF95; Region: DUF95; pfam01944 983544005421 RDD family; Region: RDD; pfam06271 983544005422 Predicted membrane protein [Function unknown]; Region: COG2860 983544005423 UPF0126 domain; Region: UPF0126; pfam03458 983544005424 UPF0126 domain; Region: UPF0126; pfam03458 983544005425 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 983544005426 dimer interface [polypeptide binding]; other site 983544005427 putative tRNA-binding site [nucleotide binding]; other site 983544005428 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 983544005429 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 983544005430 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 983544005431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983544005432 Walker A/P-loop; other site 983544005433 ATP binding site [chemical binding]; other site 983544005434 Q-loop/lid; other site 983544005435 ABC transporter signature motif; other site 983544005436 Walker B; other site 983544005437 D-loop; other site 983544005438 H-loop/switch region; other site 983544005439 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 983544005440 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 983544005441 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 983544005442 NAD binding site [chemical binding]; other site 983544005443 Phe binding site; other site 983544005444 transcription antitermination factor NusB; Region: nusB; TIGR01951 983544005445 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 983544005446 Preprotein translocase subunit; Region: YajC; pfam02699 983544005447 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 983544005448 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 983544005449 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 983544005450 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 983544005451 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 983544005452 active site 983544005453 Zn binding site [ion binding]; other site 983544005454 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 983544005455 active site 983544005456 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 983544005457 putative active site [active] 983544005458 putative CoA binding site [chemical binding]; other site 983544005459 nudix motif; other site 983544005460 metal binding site [ion binding]; metal-binding site 983544005461 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 983544005462 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 983544005463 putative acyl-acceptor binding pocket; other site 983544005464 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983544005465 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544005466 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983544005467 DNA binding residues [nucleotide binding] 983544005468 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544005469 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 983544005470 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544005471 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 983544005472 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 983544005473 Histidine kinase; Region: His_kinase; pfam06580 983544005474 2TM domain; Region: 2TM; pfam13239 983544005475 2TM domain; Region: 2TM; pfam13239 983544005476 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 983544005477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544005478 active site 983544005479 phosphorylation site [posttranslational modification] 983544005480 intermolecular recognition site; other site 983544005481 dimerization interface [polypeptide binding]; other site 983544005482 LytTr DNA-binding domain; Region: LytTR; smart00850 983544005483 LETM1-like protein; Region: LETM1; pfam07766 983544005484 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 983544005485 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 983544005486 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544005487 TPR motif; other site 983544005488 binding surface 983544005489 Alphavirus E3 glycoprotein; Region: Alpha_E3_glycop; pfam01563 983544005490 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544005491 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983544005492 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544005493 putative anti-sigmaE protein; Provisional; Region: PRK13920 983544005494 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983544005495 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544005496 DNA binding residues [nucleotide binding] 983544005497 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 983544005498 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 983544005499 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 983544005500 E-class dimer interface [polypeptide binding]; other site 983544005501 P-class dimer interface [polypeptide binding]; other site 983544005502 active site 983544005503 Cu2+ binding site [ion binding]; other site 983544005504 Zn2+ binding site [ion binding]; other site 983544005505 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 983544005506 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 983544005507 metal ion-dependent adhesion site (MIDAS); other site 983544005508 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 983544005509 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983544005510 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 983544005511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 983544005512 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 983544005513 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 983544005514 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 983544005515 putative metal binding site [ion binding]; other site 983544005516 Protein of unknown function (DUF421); Region: DUF421; pfam04239 983544005517 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983544005518 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983544005519 active site 983544005520 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 983544005521 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983544005522 dimer interface [polypeptide binding]; other site 983544005523 active site 983544005524 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 983544005525 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 983544005526 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983544005527 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983544005528 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983544005529 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 983544005530 substrate binding site [chemical binding]; other site 983544005531 oxyanion hole (OAH) forming residues; other site 983544005532 trimer interface [polypeptide binding]; other site 983544005533 Transcriptional regulators [Transcription]; Region: MarR; COG1846 983544005534 MarR family; Region: MarR_2; pfam12802 983544005535 MarR family; Region: MarR_2; cl17246 983544005536 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 983544005537 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 983544005538 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 983544005539 acyl-activating enzyme (AAE) consensus motif; other site 983544005540 acyl-activating enzyme (AAE) consensus motif; other site 983544005541 putative AMP binding site [chemical binding]; other site 983544005542 putative active site [active] 983544005543 putative CoA binding site [chemical binding]; other site 983544005544 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983544005545 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983544005546 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 983544005547 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 983544005548 dimerization interface [polypeptide binding]; other site 983544005549 ATP binding site [chemical binding]; other site 983544005550 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 983544005551 dimerization interface [polypeptide binding]; other site 983544005552 ATP binding site [chemical binding]; other site 983544005553 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 983544005554 putative active site [active] 983544005555 catalytic triad [active] 983544005556 Endonuclease I; Region: Endonuclease_1; pfam04231 983544005557 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 983544005558 Interdomain contacts; other site 983544005559 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544005560 16S rRNA methyltransferase B; Provisional; Region: PRK14902 983544005561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544005562 S-adenosylmethionine binding site [chemical binding]; other site 983544005563 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 983544005564 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544005565 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983544005566 DNA binding residues [nucleotide binding] 983544005567 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 983544005568 dimer interface [polypeptide binding]; other site 983544005569 YHYH protein; Region: YHYH; pfam14240 983544005570 YHYH protein; Region: YHYH; pfam14240 983544005571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 983544005572 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 983544005573 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 983544005574 Cu(I) binding site [ion binding]; other site 983544005575 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 983544005576 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983544005577 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544005578 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983544005579 DNA binding residues [nucleotide binding] 983544005580 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 983544005581 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 983544005582 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 983544005583 Walker A/P-loop; other site 983544005584 ATP binding site [chemical binding]; other site 983544005585 Q-loop/lid; other site 983544005586 ABC transporter signature motif; other site 983544005587 Walker B; other site 983544005588 D-loop; other site 983544005589 H-loop/switch region; other site 983544005590 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 983544005591 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 983544005592 active site 983544005593 substrate binding site [chemical binding]; other site 983544005594 metal binding site [ion binding]; metal-binding site 983544005595 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 983544005596 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 983544005597 Ligand binding site; other site 983544005598 Putative Catalytic site; other site 983544005599 DXD motif; other site 983544005600 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 983544005601 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 983544005602 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 983544005603 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 983544005604 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 983544005605 YhhN-like protein; Region: YhhN; pfam07947 983544005606 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 983544005607 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 983544005608 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 983544005609 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 983544005610 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983544005611 FeS/SAM binding site; other site 983544005612 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983544005613 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 983544005614 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983544005615 catalytic residue [active] 983544005616 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 983544005617 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 983544005618 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 983544005619 putative active site [active] 983544005620 catalytic site [active] 983544005621 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 983544005622 putative active site [active] 983544005623 catalytic site [active] 983544005624 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 983544005625 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 983544005626 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 983544005627 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 983544005628 ATP-grasp domain; Region: ATP-grasp_4; cl17255 983544005629 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 983544005630 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 983544005631 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 983544005632 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 983544005633 ATP-grasp domain; Region: ATP-grasp_4; cl17255 983544005634 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 983544005635 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 983544005636 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544005637 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 983544005638 RmuC family; Region: RmuC; pfam02646 983544005639 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 983544005640 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 983544005641 Walker A/P-loop; other site 983544005642 ATP binding site [chemical binding]; other site 983544005643 Q-loop/lid; other site 983544005644 ABC transporter signature motif; other site 983544005645 Walker B; other site 983544005646 D-loop; other site 983544005647 H-loop/switch region; other site 983544005648 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 983544005649 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 983544005650 ABC-ATPase subunit interface; other site 983544005651 dimer interface [polypeptide binding]; other site 983544005652 putative PBP binding regions; other site 983544005653 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 983544005654 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 983544005655 intersubunit interface [polypeptide binding]; other site 983544005656 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 983544005657 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544005658 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 983544005659 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 983544005660 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 983544005661 Ligand Binding Site [chemical binding]; other site 983544005662 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 983544005663 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 983544005664 protein binding site [polypeptide binding]; other site 983544005665 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 983544005666 Catalytic dyad [active] 983544005667 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 983544005668 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544005669 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983544005670 DNA binding residues [nucleotide binding] 983544005671 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 983544005672 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 983544005673 adenylosuccinate lyase; Provisional; Region: PRK09285 983544005674 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 983544005675 tetramer interface [polypeptide binding]; other site 983544005676 active site 983544005677 Haem-binding domain; Region: Haem_bd; pfam14376 983544005678 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983544005679 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 983544005680 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 983544005681 HSP70 interaction site [polypeptide binding]; other site 983544005682 KTSC domain; Region: KTSC; pfam13619 983544005683 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 983544005684 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983544005685 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983544005686 ABC transporter; Region: ABC_tran_2; pfam12848 983544005687 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983544005688 Domain of unknown function (DUF4421); Region: DUF4421; pfam14391 983544005689 NAD-dependent deacetylase; Provisional; Region: PRK00481 983544005690 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 983544005691 NAD+ binding site [chemical binding]; other site 983544005692 substrate binding site [chemical binding]; other site 983544005693 Zn binding site [ion binding]; other site 983544005694 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 983544005695 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 983544005696 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 983544005697 putative hydrophobic ligand binding site [chemical binding]; other site 983544005698 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544005699 helicase 45; Provisional; Region: PTZ00424 983544005700 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 983544005701 ATP binding site [chemical binding]; other site 983544005702 Mg++ binding site [ion binding]; other site 983544005703 motif III; other site 983544005704 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983544005705 nucleotide binding region [chemical binding]; other site 983544005706 ATP-binding site [chemical binding]; other site 983544005707 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 983544005708 RNA binding site [nucleotide binding]; other site 983544005709 Archaeal ATPase; Region: Arch_ATPase; pfam01637 983544005710 AAA domain; Region: AAA_14; pfam13173 983544005711 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 983544005712 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 983544005713 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 983544005714 active site 983544005715 dimerization interface [polypeptide binding]; other site 983544005716 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 983544005717 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 983544005718 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 983544005719 dimerization interface [polypeptide binding]; other site 983544005720 active site 983544005721 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 983544005722 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 983544005723 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 983544005724 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983544005725 ATP binding site [chemical binding]; other site 983544005726 putative Mg++ binding site [ion binding]; other site 983544005727 helicase superfamily c-terminal domain; Region: HELICc; smart00490 983544005728 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 983544005729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544005730 active site 983544005731 phosphorylation site [posttranslational modification] 983544005732 intermolecular recognition site; other site 983544005733 dimerization interface [polypeptide binding]; other site 983544005734 LytTr DNA-binding domain; Region: LytTR; smart00850 983544005735 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 983544005736 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 983544005737 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 983544005738 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 983544005739 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 983544005740 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 983544005741 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983544005742 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544005743 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 983544005744 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 983544005745 putative active site [active] 983544005746 catalytic site [active] 983544005747 putative metal binding site [ion binding]; other site 983544005748 oligomer interface [polypeptide binding]; other site 983544005749 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 983544005750 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 983544005751 dimer interface [polypeptide binding]; other site 983544005752 motif 1; other site 983544005753 active site 983544005754 motif 2; other site 983544005755 motif 3; other site 983544005756 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 983544005757 anticodon binding site; other site 983544005758 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 983544005759 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544005760 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 983544005761 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 983544005762 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544005763 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 983544005764 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 983544005765 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544005766 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 983544005767 active site 983544005768 Zn binding site [ion binding]; other site 983544005769 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 983544005770 Interdomain contacts; other site 983544005771 Cytokine receptor motif; other site 983544005772 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 983544005773 HYR domain; Region: HYR; pfam02494 983544005774 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544005775 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 983544005776 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 983544005777 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 983544005778 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 983544005779 active sites [active] 983544005780 tetramer interface [polypeptide binding]; other site 983544005781 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983544005782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983544005783 NAD(P) binding site [chemical binding]; other site 983544005784 active site 983544005785 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 983544005786 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 983544005787 dimer interface [polypeptide binding]; other site 983544005788 active site 983544005789 Phosphopantetheine attachment site; Region: PP-binding; cl09936 983544005790 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 983544005791 putative acyl-acceptor binding pocket; other site 983544005792 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 983544005793 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 983544005794 dimer interface [polypeptide binding]; other site 983544005795 active site 983544005796 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983544005797 active site 2 [active] 983544005798 active site 1 [active] 983544005799 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 983544005800 dimer interface [polypeptide binding]; other site 983544005801 active site 1 [active] 983544005802 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 983544005803 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 983544005804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983544005805 Walker A/P-loop; other site 983544005806 ATP binding site [chemical binding]; other site 983544005807 Q-loop/lid; other site 983544005808 ABC transporter signature motif; other site 983544005809 Walker B; other site 983544005810 D-loop; other site 983544005811 H-loop/switch region; other site 983544005812 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 983544005813 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 983544005814 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 983544005815 active site 983544005816 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 983544005817 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 983544005818 active site 983544005819 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 983544005820 Phosphopantetheine attachment site; Region: PP-binding; cl09936 983544005821 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 983544005822 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 983544005823 dimer interface [polypeptide binding]; other site 983544005824 active site 983544005825 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 983544005826 active site 983544005827 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 983544005828 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 983544005829 NodB motif; other site 983544005830 active site 983544005831 catalytic site [active] 983544005832 metal binding site [ion binding]; metal-binding site 983544005833 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 983544005834 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 983544005835 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983544005836 active site 2 [active] 983544005837 active site 1 [active] 983544005838 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 983544005839 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 983544005840 Ligand binding site; other site 983544005841 Putative Catalytic site; other site 983544005842 DXD motif; other site 983544005843 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 983544005844 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 983544005845 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 983544005846 putative acyl-acceptor binding pocket; other site 983544005847 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 983544005848 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 983544005849 Cupin-like domain; Region: Cupin_8; pfam13621 983544005850 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 983544005851 active site 983544005852 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983544005853 TPR motif; other site 983544005854 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 983544005855 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 983544005856 acyl-activating enzyme (AAE) consensus motif; other site 983544005857 AMP binding site [chemical binding]; other site 983544005858 active site 983544005859 CoA binding site [chemical binding]; other site 983544005860 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983544005861 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983544005862 DNA binding site [nucleotide binding] 983544005863 domain linker motif; other site 983544005864 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 983544005865 dimerization interface [polypeptide binding]; other site 983544005866 ligand binding site [chemical binding]; other site 983544005867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544005868 binding surface 983544005869 TPR motif; other site 983544005870 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983544005871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 983544005872 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 983544005873 ATP binding site [chemical binding]; other site 983544005874 Mg2+ binding site [ion binding]; other site 983544005875 G-X-G motif; other site 983544005876 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983544005877 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 983544005878 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; cl01757 983544005879 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 983544005880 Active_site [active] 983544005881 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 983544005882 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 983544005883 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983544005884 ATP binding site [chemical binding]; other site 983544005885 putative Mg++ binding site [ion binding]; other site 983544005886 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983544005887 nucleotide binding region [chemical binding]; other site 983544005888 ATP-binding site [chemical binding]; other site 983544005889 Protein of unknown function DUF262; Region: DUF262; pfam03235 983544005890 Uncharacterized conserved protein [Function unknown]; Region: COG1479 983544005891 Protein of unknown function DUF262; Region: DUF262; pfam03235 983544005892 Uncharacterized conserved protein [Function unknown]; Region: COG1479 983544005893 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 983544005894 HsdM N-terminal domain; Region: HsdM_N; pfam12161 983544005895 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 983544005896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 983544005897 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 983544005898 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 983544005899 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 983544005900 AAA domain; Region: AAA_23; pfam13476 983544005901 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983544005902 Walker A/P-loop; other site 983544005903 ATP binding site [chemical binding]; other site 983544005904 AAA domain; Region: AAA_21; pfam13304 983544005905 AAA domain; Region: AAA_13; pfam13166 983544005906 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983544005907 ligand binding site [chemical binding]; other site 983544005908 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 983544005909 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 983544005910 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 983544005911 Predicted transcriptional regulator [Transcription]; Region: COG2378 983544005912 WYL domain; Region: WYL; pfam13280 983544005913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544005914 active site 983544005915 phosphorylation site [posttranslational modification] 983544005916 intermolecular recognition site; other site 983544005917 dimerization interface [polypeptide binding]; other site 983544005918 LytTr DNA-binding domain; Region: LytTR; smart00850 983544005919 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 983544005920 cytidylate kinase; Provisional; Region: PRK04182 983544005921 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 983544005922 active site 983544005923 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983544005924 FeS/SAM binding site; other site 983544005925 Radical SAM superfamily; Region: Radical_SAM; pfam04055 983544005926 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 983544005927 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 983544005928 hydrophobic ligand binding site; other site 983544005929 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 983544005930 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 983544005931 homodimer interface [polypeptide binding]; other site 983544005932 substrate-cofactor binding pocket; other site 983544005933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544005934 catalytic residue [active] 983544005935 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 983544005936 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 983544005937 IHF - DNA interface [nucleotide binding]; other site 983544005938 IHF dimer interface [polypeptide binding]; other site 983544005939 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 983544005940 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 983544005941 putative active site [active] 983544005942 substrate binding site [chemical binding]; other site 983544005943 putative cosubstrate binding site; other site 983544005944 catalytic site [active] 983544005945 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 983544005946 substrate binding site [chemical binding]; other site 983544005947 DEAD-like helicases superfamily; Region: DEXDc; smart00487 983544005948 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983544005949 ATP binding site [chemical binding]; other site 983544005950 putative Mg++ binding site [ion binding]; other site 983544005951 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983544005952 nucleotide binding region [chemical binding]; other site 983544005953 ATP-binding site [chemical binding]; other site 983544005954 Predicted ATPase [General function prediction only]; Region: COG3911 983544005955 AAA domain; Region: AAA_28; pfam13521 983544005956 Protein of unknown function (DUF493); Region: DUF493; pfam04359 983544005957 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 983544005958 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 983544005959 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 983544005960 hinge; other site 983544005961 active site 983544005962 SnoaL-like domain; Region: SnoaL_2; pfam12680 983544005963 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 983544005964 DNA photolyase; Region: DNA_photolyase; pfam00875 983544005965 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 983544005966 putative hydrophobic ligand binding site [chemical binding]; other site 983544005967 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 983544005968 classical (c) SDRs; Region: SDR_c; cd05233 983544005969 NAD(P) binding site [chemical binding]; other site 983544005970 active site 983544005971 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 983544005972 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 983544005973 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 983544005974 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 983544005975 DNA photolyase; Region: DNA_photolyase; pfam00875 983544005976 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 983544005977 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 983544005978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983544005979 NAD(P) binding site [chemical binding]; other site 983544005980 active site 983544005981 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 983544005982 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 983544005983 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 983544005984 ABC1 family; Region: ABC1; cl17513 983544005985 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 983544005986 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 983544005987 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983544005988 active site 983544005989 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983544005990 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 983544005991 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 983544005992 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 983544005993 Na binding site [ion binding]; other site 983544005994 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 983544005995 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 983544005996 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 983544005997 oligomer interface [polypeptide binding]; other site 983544005998 metal binding site [ion binding]; metal-binding site 983544005999 metal binding site [ion binding]; metal-binding site 983544006000 Cl binding site [ion binding]; other site 983544006001 aspartate ring; other site 983544006002 basic sphincter; other site 983544006003 putative hydrophobic gate; other site 983544006004 periplasmic entrance; other site 983544006005 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 983544006006 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983544006007 Maf-like protein; Reviewed; Region: PRK00078 983544006008 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 983544006009 active site 983544006010 dimer interface [polypeptide binding]; other site 983544006011 prenyltransferase; Reviewed; Region: ubiA; PRK12872 983544006012 UbiA prenyltransferase family; Region: UbiA; pfam01040 983544006013 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 983544006014 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983544006015 active site 983544006016 motif I; other site 983544006017 motif II; other site 983544006018 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 983544006019 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 983544006020 heme-binding site [chemical binding]; other site 983544006021 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 983544006022 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 983544006023 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 983544006024 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 983544006025 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 983544006026 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 983544006027 homodimer interface [polypeptide binding]; other site 983544006028 substrate-cofactor binding pocket; other site 983544006029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544006030 catalytic residue [active] 983544006031 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 983544006032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544006033 S-adenosylmethionine binding site [chemical binding]; other site 983544006034 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 983544006035 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 983544006036 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 983544006037 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 983544006038 Peptidase family M28; Region: Peptidase_M28; pfam04389 983544006039 metal binding site [ion binding]; metal-binding site 983544006040 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 983544006041 Peptidase family M28; Region: Peptidase_M28; pfam04389 983544006042 metal binding site [ion binding]; metal-binding site 983544006043 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 983544006044 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 983544006045 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 983544006046 active site 983544006047 catalytic site [active] 983544006048 substrate binding site [chemical binding]; other site 983544006049 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 983544006050 GIY-YIG motif/motif A; other site 983544006051 active site 983544006052 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 983544006053 catalytic site [active] 983544006054 metal binding site [ion binding]; metal-binding site 983544006055 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 983544006056 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 983544006057 dimer interface [polypeptide binding]; other site 983544006058 FMN binding site [chemical binding]; other site 983544006059 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 983544006060 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 983544006061 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 983544006062 inhibitor-cofactor binding pocket; inhibition site 983544006063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544006064 catalytic residue [active] 983544006065 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 983544006066 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 983544006067 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 983544006068 dimerization interface [polypeptide binding]; other site 983544006069 active site 983544006070 Predicted permeases [General function prediction only]; Region: COG0795 983544006071 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 983544006072 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 983544006073 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 983544006074 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 983544006075 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 983544006076 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 983544006077 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 983544006078 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 983544006079 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 983544006080 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 983544006081 dimer interface [polypeptide binding]; other site 983544006082 catalytic triad [active] 983544006083 peroxidatic and resolving cysteines [active] 983544006084 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 983544006085 Fasciclin domain; Region: Fasciclin; pfam02469 983544006086 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 983544006087 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 983544006088 heme binding site [chemical binding]; other site 983544006089 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 983544006090 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 983544006091 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 983544006092 Alginate lyase; Region: Alginate_lyase2; pfam08787 983544006093 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 983544006094 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983544006095 NAD(P) binding site [chemical binding]; other site 983544006096 catalytic residues [active] 983544006097 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 983544006098 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983544006099 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983544006100 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983544006101 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 983544006102 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983544006103 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 983544006104 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 983544006105 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983544006106 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544006107 binding surface 983544006108 TPR motif; other site 983544006109 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983544006110 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983544006111 Histidine kinase; Region: HisKA_3; pfam07730 983544006112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544006113 ATP binding site [chemical binding]; other site 983544006114 Mg2+ binding site [ion binding]; other site 983544006115 G-X-G motif; other site 983544006116 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983544006117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544006118 active site 983544006119 phosphorylation site [posttranslational modification] 983544006120 intermolecular recognition site; other site 983544006121 dimerization interface [polypeptide binding]; other site 983544006122 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983544006123 DNA binding residues [nucleotide binding] 983544006124 dimerization interface [polypeptide binding]; other site 983544006125 Protein of unknown function (DUF541); Region: SIMPL; cl01077 983544006126 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 983544006127 short chain dehydrogenase; Provisional; Region: PRK06924 983544006128 NADP binding site [chemical binding]; other site 983544006129 active site 983544006130 steroid binding site; other site 983544006131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983544006132 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983544006133 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983544006134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983544006135 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 983544006136 dimerization interface [polypeptide binding]; other site 983544006137 substrate binding pocket [chemical binding]; other site 983544006138 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 983544006139 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 983544006140 catalytic residues [active] 983544006141 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 983544006142 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 983544006143 dimer interface [polypeptide binding]; other site 983544006144 decamer (pentamer of dimers) interface [polypeptide binding]; other site 983544006145 catalytic triad [active] 983544006146 peroxidatic and resolving cysteines [active] 983544006147 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 983544006148 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 983544006149 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983544006150 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983544006151 catalytic residue [active] 983544006152 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983544006153 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983544006154 putative DNA binding site [nucleotide binding]; other site 983544006155 putative Zn2+ binding site [ion binding]; other site 983544006156 AsnC family; Region: AsnC_trans_reg; pfam01037 983544006157 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983544006158 DNA binding residues [nucleotide binding] 983544006159 dimerization interface [polypeptide binding]; other site 983544006160 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 983544006161 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 983544006162 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983544006163 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 983544006164 Methyltransferase domain; Region: Methyltransf_23; pfam13489 983544006165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544006166 S-adenosylmethionine binding site [chemical binding]; other site 983544006167 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 983544006168 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 983544006169 ATP binding site [chemical binding]; other site 983544006170 Mg++ binding site [ion binding]; other site 983544006171 motif III; other site 983544006172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983544006173 nucleotide binding region [chemical binding]; other site 983544006174 ATP-binding site [chemical binding]; other site 983544006175 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 983544006176 active site 983544006177 catalytic residues [active] 983544006178 TraB family; Region: TraB; pfam01963 983544006179 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 983544006180 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 983544006181 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 983544006182 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 983544006183 Ligand Binding Site [chemical binding]; other site 983544006184 TilS substrate C-terminal domain; Region: TilS_C; smart00977 983544006185 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 983544006186 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 983544006187 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 983544006188 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 983544006189 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983544006190 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 983544006191 active site 983544006192 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 983544006193 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 983544006194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983544006195 Walker A motif; other site 983544006196 ATP binding site [chemical binding]; other site 983544006197 Walker B motif; other site 983544006198 arginine finger; other site 983544006199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983544006200 ATP binding site [chemical binding]; other site 983544006201 Walker B motif; other site 983544006202 arginine finger; other site 983544006203 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 983544006204 Protein of unknown function (DUF877); Region: DUF877; pfam05943 983544006205 RHS Repeat; Region: RHS_repeat; pfam05593 983544006206 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 983544006207 RHS Repeat; Region: RHS_repeat; pfam05593 983544006208 RHS Repeat; Region: RHS_repeat; cl11982 983544006209 RHS Repeat; Region: RHS_repeat; pfam05593 983544006210 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 983544006211 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 983544006212 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 983544006213 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 983544006214 Peptidase family M23; Region: Peptidase_M23; pfam01551 983544006215 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 983544006216 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 983544006217 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 983544006218 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 983544006219 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544006220 NlpC/P60 family; Region: NLPC_P60; pfam00877 983544006221 FOG: PKD repeat [General function prediction only]; Region: COG3291 983544006222 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 983544006223 PKD domain; Region: PKD; pfam00801 983544006224 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 983544006225 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 983544006226 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 983544006227 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 983544006228 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 983544006229 catalytic residues [active] 983544006230 catalytic nucleophile [active] 983544006231 Recombinase; Region: Recombinase; pfam07508 983544006232 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 983544006233 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 983544006234 multiple promoter invertase; Provisional; Region: mpi; PRK13413 983544006235 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 983544006236 catalytic residues [active] 983544006237 catalytic nucleophile [active] 983544006238 Presynaptic Site I dimer interface [polypeptide binding]; other site 983544006239 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 983544006240 Synaptic Flat tetramer interface [polypeptide binding]; other site 983544006241 Synaptic Site I dimer interface [polypeptide binding]; other site 983544006242 DNA binding site [nucleotide binding] 983544006243 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 983544006244 putative catalytic site [active] 983544006245 putative metal binding site [ion binding]; other site 983544006246 putative phosphate binding site [ion binding]; other site 983544006247 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 983544006248 GIY-YIG motif/motif A; other site 983544006249 putative active site [active] 983544006250 putative metal binding site [ion binding]; other site 983544006251 PhoH-like protein; Region: PhoH; cl17668 983544006252 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 983544006253 Uncharacterized conserved protein [Function unknown]; Region: COG3410 983544006254 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 983544006255 metal binding site [ion binding]; metal-binding site 983544006256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544006257 binding surface 983544006258 TPR motif; other site 983544006259 Tetratricopeptide repeat; Region: TPR_16; pfam13432 983544006260 TPR repeat; Region: TPR_11; pfam13414 983544006261 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544006262 binding surface 983544006263 TPR motif; other site 983544006264 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983544006265 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 983544006266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983544006267 Walker A motif; other site 983544006268 ATP binding site [chemical binding]; other site 983544006269 Walker B motif; other site 983544006270 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 983544006271 Histidine kinase; Region: HisKA_3; pfam07730 983544006272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544006273 ATP binding site [chemical binding]; other site 983544006274 Mg2+ binding site [ion binding]; other site 983544006275 G-X-G motif; other site 983544006276 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 983544006277 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 983544006278 NAD(P) binding site [chemical binding]; other site 983544006279 catalytic residues [active] 983544006280 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 983544006281 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 983544006282 active site 983544006283 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 983544006284 oligomerization interface [polypeptide binding]; other site 983544006285 active site 983544006286 metal binding site [ion binding]; metal-binding site 983544006287 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 983544006288 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 983544006289 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 983544006290 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 983544006291 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 983544006292 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 983544006293 nucleotide binding site [chemical binding]; other site 983544006294 NEF interaction site [polypeptide binding]; other site 983544006295 SBD interface [polypeptide binding]; other site 983544006296 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 983544006297 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 983544006298 FMN binding site [chemical binding]; other site 983544006299 substrate binding site [chemical binding]; other site 983544006300 putative catalytic residue [active] 983544006301 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 983544006302 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983544006303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 983544006304 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983544006305 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 983544006306 CoenzymeA binding site [chemical binding]; other site 983544006307 subunit interaction site [polypeptide binding]; other site 983544006308 PHB binding site; other site 983544006309 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 983544006310 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 983544006311 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 983544006312 dimer interface [polypeptide binding]; other site 983544006313 tetramer interface [polypeptide binding]; other site 983544006314 PYR/PP interface [polypeptide binding]; other site 983544006315 TPP binding site [chemical binding]; other site 983544006316 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 983544006317 TPP-binding site; other site 983544006318 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 983544006319 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 983544006320 S1 domain; Region: S1_2; pfam13509 983544006321 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983544006322 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 983544006323 substrate binding site [chemical binding]; other site 983544006324 oxyanion hole (OAH) forming residues; other site 983544006325 trimer interface [polypeptide binding]; other site 983544006326 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 983544006327 UbiA prenyltransferase family; Region: UbiA; pfam01040 983544006328 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 983544006329 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 983544006330 active site 983544006331 CAAX protease self-immunity; Region: Abi; pfam02517 983544006332 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 983544006333 acyl-activating enzyme (AAE) consensus motif; other site 983544006334 AMP binding site [chemical binding]; other site 983544006335 active site 983544006336 CoA binding site [chemical binding]; other site 983544006337 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544006338 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 983544006339 von Willebrand factor; Region: vWF_A; pfam12450 983544006340 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 983544006341 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 983544006342 metal ion-dependent adhesion site (MIDAS); other site 983544006343 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 983544006344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983544006345 putative substrate translocation pore; other site 983544006346 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983544006347 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 983544006348 Predicted flavoprotein [General function prediction only]; Region: COG0431 983544006349 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 983544006350 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 983544006351 MarR family; Region: MarR_2; cl17246 983544006352 Pirin; Region: Pirin; pfam02678 983544006353 Pirin-related protein [General function prediction only]; Region: COG1741 983544006354 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 983544006355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983544006356 Walker A/P-loop; other site 983544006357 ATP binding site [chemical binding]; other site 983544006358 Q-loop/lid; other site 983544006359 ABC transporter signature motif; other site 983544006360 Walker B; other site 983544006361 D-loop; other site 983544006362 H-loop/switch region; other site 983544006363 ABC transporter; Region: ABC_tran_2; pfam12848 983544006364 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983544006365 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 983544006366 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983544006367 PemK-like protein; Region: PemK; pfam02452 983544006368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 983544006369 Walker A motif; other site 983544006370 ATP binding site [chemical binding]; other site 983544006371 Walker B motif; other site 983544006372 arginine finger; other site 983544006373 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 983544006374 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 983544006375 dimer interface [polypeptide binding]; other site 983544006376 ADP-ribose binding site [chemical binding]; other site 983544006377 active site 983544006378 nudix motif; other site 983544006379 metal binding site [ion binding]; metal-binding site 983544006380 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 983544006381 GIY-YIG motif/motif A; other site 983544006382 putative active site [active] 983544006383 putative metal binding site [ion binding]; other site 983544006384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983544006385 Coenzyme A binding pocket [chemical binding]; other site 983544006386 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 983544006387 putative active site [active] 983544006388 putative metal binding site [ion binding]; other site 983544006389 imidazolonepropionase; Validated; Region: PRK09356 983544006390 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 983544006391 active site 983544006392 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 983544006393 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983544006394 ligand binding site [chemical binding]; other site 983544006395 flexible hinge region; other site 983544006396 fumarate hydratase; Reviewed; Region: fumC; PRK00485 983544006397 Class II fumarases; Region: Fumarase_classII; cd01362 983544006398 active site 983544006399 tetramer interface [polypeptide binding]; other site 983544006400 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 983544006401 Mannose-6-phosphate receptor; Region: Man-6-P_recep; pfam02157 983544006402 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544006403 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983544006404 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544006405 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983544006406 ArsC family; Region: ArsC; pfam03960 983544006407 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 983544006408 ArsC family; Region: ArsC; pfam03960 983544006409 catalytic residues [active] 983544006410 peptide chain release factor 2; Validated; Region: prfB; PRK00578 983544006411 This domain is found in peptide chain release factors; Region: PCRF; smart00937 983544006412 RF-1 domain; Region: RF-1; pfam00472 983544006413 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 983544006414 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 983544006415 tetramer interface [polypeptide binding]; other site 983544006416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544006417 catalytic residue [active] 983544006418 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983544006419 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 983544006420 ligand binding site [chemical binding]; other site 983544006421 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 983544006422 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 983544006423 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 983544006424 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 983544006425 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 983544006426 dimer interface [polypeptide binding]; other site 983544006427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544006428 catalytic residue [active] 983544006429 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 983544006430 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983544006431 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983544006432 catalytic residue [active] 983544006433 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 983544006434 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 983544006435 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983544006436 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983544006437 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 983544006438 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 983544006439 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 983544006440 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 983544006441 ATP binding site [chemical binding]; other site 983544006442 putative Mg++ binding site [ion binding]; other site 983544006443 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 983544006444 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 983544006445 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 983544006446 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 983544006447 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 983544006448 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 983544006449 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983544006450 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544006451 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983544006452 DNA binding residues [nucleotide binding] 983544006453 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 983544006454 endonuclease III; Region: ENDO3c; smart00478 983544006455 minor groove reading motif; other site 983544006456 helix-hairpin-helix signature motif; other site 983544006457 substrate binding pocket [chemical binding]; other site 983544006458 active site 983544006459 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 983544006460 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 983544006461 catalytic triad [active] 983544006462 hypothetical protein; Provisional; Region: PRK12378 983544006463 C-terminal peptidase (prc); Region: prc; TIGR00225 983544006464 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 983544006465 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 983544006466 Catalytic dyad [active] 983544006467 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 983544006468 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 983544006469 aromatic arch; other site 983544006470 DCoH dimer interaction site [polypeptide binding]; other site 983544006471 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 983544006472 DCoH tetramer interaction site [polypeptide binding]; other site 983544006473 substrate binding site [chemical binding]; other site 983544006474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983544006475 NAD(P) binding site [chemical binding]; other site 983544006476 active site 983544006477 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 983544006478 glutaminase; Provisional; Region: PRK00971 983544006479 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 983544006480 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 983544006481 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 983544006482 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 983544006483 active site 983544006484 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 983544006485 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 983544006486 NADH(P)-binding; Region: NAD_binding_10; pfam13460 983544006487 NAD(P) binding site [chemical binding]; other site 983544006488 putative active site [active] 983544006489 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544006490 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 983544006491 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983544006492 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 983544006493 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 983544006494 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 983544006495 putative ligand binding site [chemical binding]; other site 983544006496 NAD binding site [chemical binding]; other site 983544006497 dimerization interface [polypeptide binding]; other site 983544006498 catalytic site [active] 983544006499 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 983544006500 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983544006501 catalytic residue [active] 983544006502 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 983544006503 NAD(P) binding site [chemical binding]; other site 983544006504 4Fe-4S binding domain; Region: Fer4; pfam00037 983544006505 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 983544006506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 983544006507 GTP-binding protein YchF; Reviewed; Region: PRK09601 983544006508 YchF GTPase; Region: YchF; cd01900 983544006509 G1 box; other site 983544006510 GTP/Mg2+ binding site [chemical binding]; other site 983544006511 Switch I region; other site 983544006512 G2 box; other site 983544006513 Switch II region; other site 983544006514 G3 box; other site 983544006515 G4 box; other site 983544006516 G5 box; other site 983544006517 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 983544006518 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 983544006519 active site 983544006520 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 983544006521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544006522 ATP binding site [chemical binding]; other site 983544006523 Mg2+ binding site [ion binding]; other site 983544006524 G-X-G motif; other site 983544006525 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 983544006526 ATP binding site [chemical binding]; other site 983544006527 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 983544006528 active site 983544006529 putative metal-binding site [ion binding]; other site 983544006530 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 983544006531 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 983544006532 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 983544006533 CAP-like domain; other site 983544006534 active site 983544006535 primary dimer interface [polypeptide binding]; other site 983544006536 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 983544006537 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983544006538 non-specific DNA binding site [nucleotide binding]; other site 983544006539 salt bridge; other site 983544006540 sequence-specific DNA binding site [nucleotide binding]; other site 983544006541 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 983544006542 putative active site [active] 983544006543 Zn binding site [ion binding]; other site 983544006544 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 983544006545 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983544006546 putative DNA binding site [nucleotide binding]; other site 983544006547 putative Zn2+ binding site [ion binding]; other site 983544006548 AsnC family; Region: AsnC_trans_reg; pfam01037 983544006549 DinB superfamily; Region: DinB_2; pfam12867 983544006550 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 983544006551 active site 983544006552 dimer interface [polypeptide binding]; other site 983544006553 metal binding site [ion binding]; metal-binding site 983544006554 proline dehydrogenase; Region: PLN02681 983544006555 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 983544006556 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 983544006557 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 983544006558 hexamer interface [polypeptide binding]; other site 983544006559 ligand binding site [chemical binding]; other site 983544006560 putative active site [active] 983544006561 NAD(P) binding site [chemical binding]; other site 983544006562 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 983544006563 Response regulator receiver domain; Region: Response_reg; pfam00072 983544006564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544006565 active site 983544006566 phosphorylation site [posttranslational modification] 983544006567 intermolecular recognition site; other site 983544006568 dimerization interface [polypeptide binding]; other site 983544006569 PglZ domain; Region: PglZ; pfam08665 983544006570 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 983544006571 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983544006572 Zn2+ binding site [ion binding]; other site 983544006573 Mg2+ binding site [ion binding]; other site 983544006574 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 983544006575 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 983544006576 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 983544006577 trimer interface [polypeptide binding]; other site 983544006578 active site 983544006579 UDP-GlcNAc binding site [chemical binding]; other site 983544006580 lipid binding site [chemical binding]; lipid-binding site 983544006581 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 983544006582 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 983544006583 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 983544006584 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 983544006585 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 983544006586 active site 983544006587 elongation factor P; Validated; Region: PRK00529 983544006588 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 983544006589 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 983544006590 RNA binding site [nucleotide binding]; other site 983544006591 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 983544006592 RNA binding site [nucleotide binding]; other site 983544006593 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 983544006594 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 983544006595 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 983544006596 trimer interface [polypeptide binding]; other site 983544006597 active site 983544006598 UDP-GlcNAc binding site [chemical binding]; other site 983544006599 lipid binding site [chemical binding]; lipid-binding site 983544006600 SnoaL-like domain; Region: SnoaL_2; pfam12680 983544006601 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 983544006602 CoA binding domain; Region: CoA_binding; smart00881 983544006603 CoA-ligase; Region: Ligase_CoA; pfam00549 983544006604 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 983544006605 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 983544006606 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 983544006607 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 983544006608 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 983544006609 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 983544006610 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 983544006611 NAD(P) binding site [chemical binding]; other site 983544006612 homotetramer interface [polypeptide binding]; other site 983544006613 homodimer interface [polypeptide binding]; other site 983544006614 active site 983544006615 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 983544006616 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 983544006617 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 983544006618 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 983544006619 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 983544006620 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 983544006621 histidinol dehydrogenase; Region: hisD; TIGR00069 983544006622 NAD binding site [chemical binding]; other site 983544006623 dimerization interface [polypeptide binding]; other site 983544006624 product binding site; other site 983544006625 substrate binding site [chemical binding]; other site 983544006626 zinc binding site [ion binding]; other site 983544006627 catalytic residues [active] 983544006628 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 983544006629 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983544006630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544006631 homodimer interface [polypeptide binding]; other site 983544006632 catalytic residue [active] 983544006633 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 983544006634 GIY-YIG motif/motif A; other site 983544006635 putative active site [active] 983544006636 putative metal binding site [ion binding]; other site 983544006637 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 983544006638 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983544006639 active site 983544006640 motif I; other site 983544006641 motif II; other site 983544006642 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 983544006643 putative active site pocket [active] 983544006644 4-fold oligomerization interface [polypeptide binding]; other site 983544006645 metal binding residues [ion binding]; metal-binding site 983544006646 3-fold/trimer interface [polypeptide binding]; other site 983544006647 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 983544006648 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 983544006649 putative active site [active] 983544006650 oxyanion strand; other site 983544006651 catalytic triad [active] 983544006652 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 983544006653 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 983544006654 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 983544006655 catalytic residues [active] 983544006656 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 983544006657 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 983544006658 substrate binding site [chemical binding]; other site 983544006659 glutamase interaction surface [polypeptide binding]; other site 983544006660 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 983544006661 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 983544006662 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 983544006663 metal binding site [ion binding]; metal-binding site 983544006664 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 983544006665 Active site serine [active] 983544006666 LytTr DNA-binding domain; Region: LytTR; smart00850 983544006667 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 983544006668 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 983544006669 active site 983544006670 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 983544006671 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 983544006672 dimerization interface [polypeptide binding]; other site 983544006673 DPS ferroxidase diiron center [ion binding]; other site 983544006674 ion pore; other site 983544006675 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 983544006676 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983544006677 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 983544006678 Protein of unknown function DUF72; Region: DUF72; pfam01904 983544006679 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 983544006680 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 983544006681 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 983544006682 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 983544006683 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 983544006684 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 983544006685 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 983544006686 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 983544006687 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 983544006688 TLC ATP/ADP transporter; Region: TLC; cl03940 983544006689 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 983544006690 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 983544006691 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 983544006692 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 983544006693 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 983544006694 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 983544006695 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 983544006696 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 983544006697 putative catalytic residues [active] 983544006698 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 983544006699 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 983544006700 putative NAD(P) binding site [chemical binding]; other site 983544006701 putative substrate binding site [chemical binding]; other site 983544006702 catalytic Zn binding site [ion binding]; other site 983544006703 structural Zn binding site [ion binding]; other site 983544006704 dimer interface [polypeptide binding]; other site 983544006705 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 983544006706 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983544006707 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 983544006708 NAD(P) binding site [chemical binding]; other site 983544006709 catalytic residues [active] 983544006710 DEAD-like helicases superfamily; Region: DEXDc; smart00487 983544006711 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 983544006712 ATP binding site [chemical binding]; other site 983544006713 putative Mg++ binding site [ion binding]; other site 983544006714 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983544006715 nucleotide binding region [chemical binding]; other site 983544006716 ATP-binding site [chemical binding]; other site 983544006717 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 983544006718 RNA binding site [nucleotide binding]; other site 983544006719 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 983544006720 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 983544006721 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 983544006722 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 983544006723 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 983544006724 trimer interface [polypeptide binding]; other site 983544006725 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 983544006726 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 983544006727 aspartate racemase; Region: asp_race; TIGR00035 983544006728 Predicted transcriptional regulators [Transcription]; Region: COG1733 983544006729 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 983544006730 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 983544006731 dimer interface [polypeptide binding]; other site 983544006732 FMN binding site [chemical binding]; other site 983544006733 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 983544006734 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 983544006735 putative NAD(P) binding site [chemical binding]; other site 983544006736 dimer interface [polypeptide binding]; other site 983544006737 Cupin domain; Region: Cupin_2; pfam07883 983544006738 Cupin domain; Region: Cupin_2; cl17218 983544006739 Major royal jelly protein; Region: MRJP; pfam03022 983544006740 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 983544006741 Helix-turn-helix domain; Region: HTH_18; pfam12833 983544006742 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 983544006743 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983544006744 substrate binding site [chemical binding]; other site 983544006745 oxyanion hole (OAH) forming residues; other site 983544006746 trimer interface [polypeptide binding]; other site 983544006747 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 983544006748 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 983544006749 putative NAD(P) binding site [chemical binding]; other site 983544006750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983544006751 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 983544006752 NAD(P) binding site [chemical binding]; other site 983544006753 active site 983544006754 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 983544006755 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 983544006756 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 983544006757 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 983544006758 TrkA-N domain; Region: TrkA_N; pfam02254 983544006759 Helix-turn-helix domain; Region: HTH_18; pfam12833 983544006760 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983544006761 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 983544006762 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 983544006763 FAD binding pocket [chemical binding]; other site 983544006764 conserved FAD binding motif [chemical binding]; other site 983544006765 EamA-like transporter family; Region: EamA; cl17759 983544006766 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 983544006767 hydroperoxidase II; Provisional; Region: katE; PRK11249 983544006768 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 983544006769 tetramer interface [polypeptide binding]; other site 983544006770 heme binding pocket [chemical binding]; other site 983544006771 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 983544006772 domain interactions; other site 983544006773 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 983544006774 Helix-turn-helix domain; Region: HTH_18; pfam12833 983544006775 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983544006776 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 983544006777 nudix motif; other site 983544006778 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 983544006779 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 983544006780 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 983544006781 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 983544006782 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 983544006783 Walker A/P-loop; other site 983544006784 ATP binding site [chemical binding]; other site 983544006785 Q-loop/lid; other site 983544006786 ABC transporter signature motif; other site 983544006787 Walker B; other site 983544006788 D-loop; other site 983544006789 H-loop/switch region; other site 983544006790 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 983544006791 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 983544006792 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 983544006793 TM-ABC transporter signature motif; other site 983544006794 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 983544006795 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 983544006796 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 983544006797 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 983544006798 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 983544006799 putative substrate binding site [chemical binding]; other site 983544006800 putative ATP binding site [chemical binding]; other site 983544006801 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 983544006802 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 983544006803 potential catalytic triad [active] 983544006804 conserved cys residue [active] 983544006805 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 983544006806 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 983544006807 dimer interface [polypeptide binding]; other site 983544006808 active site 983544006809 metal binding site [ion binding]; metal-binding site 983544006810 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 983544006811 Prostaglandin dehydrogenases; Region: PGDH; cd05288 983544006812 NAD(P) binding site [chemical binding]; other site 983544006813 substrate binding site [chemical binding]; other site 983544006814 dimer interface [polypeptide binding]; other site 983544006815 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 983544006816 dimer interface [polypeptide binding]; other site 983544006817 FMN binding site [chemical binding]; other site 983544006818 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 983544006819 NAD binding site [chemical binding]; other site 983544006820 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 983544006821 active site 983544006822 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983544006823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983544006824 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 983544006825 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 983544006826 FMN binding site [chemical binding]; other site 983544006827 active site 983544006828 substrate binding site [chemical binding]; other site 983544006829 catalytic residue [active] 983544006830 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 983544006831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983544006832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983544006833 Bacterial transcriptional repressor; Region: TetR; pfam13972 983544006834 Protein of unknown function (DUF962); Region: DUF962; cl01879 983544006835 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983544006836 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 983544006837 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 983544006838 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 983544006839 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983544006840 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 983544006841 ligand binding site [chemical binding]; other site 983544006842 flexible hinge region; other site 983544006843 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 983544006844 putative switch regulator; other site 983544006845 non-specific DNA interactions [nucleotide binding]; other site 983544006846 DNA binding site [nucleotide binding] 983544006847 sequence specific DNA binding site [nucleotide binding]; other site 983544006848 putative cAMP binding site [chemical binding]; other site 983544006849 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983544006850 active site 983544006851 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 983544006852 30S subunit binding site; other site 983544006853 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 983544006854 PUA domain; Region: PUA; cl00607 983544006855 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 983544006856 putative RNA binding site [nucleotide binding]; other site 983544006857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544006858 S-adenosylmethionine binding site [chemical binding]; other site 983544006859 helicase 45; Provisional; Region: PTZ00424 983544006860 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 983544006861 ATP binding site [chemical binding]; other site 983544006862 Mg++ binding site [ion binding]; other site 983544006863 motif III; other site 983544006864 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983544006865 nucleotide binding region [chemical binding]; other site 983544006866 ATP-binding site [chemical binding]; other site 983544006867 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 983544006868 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983544006869 ATP binding site [chemical binding]; other site 983544006870 putative Mg++ binding site [ion binding]; other site 983544006871 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983544006872 nucleotide binding region [chemical binding]; other site 983544006873 ATP-binding site [chemical binding]; other site 983544006874 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 983544006875 DNA topoisomerase III; Provisional; Region: PRK07726 983544006876 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 983544006877 active site 983544006878 putative interdomain interaction site [polypeptide binding]; other site 983544006879 putative metal-binding site [ion binding]; other site 983544006880 putative nucleotide binding site [chemical binding]; other site 983544006881 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 983544006882 domain I; other site 983544006883 DNA binding groove [nucleotide binding] 983544006884 phosphate binding site [ion binding]; other site 983544006885 domain II; other site 983544006886 domain III; other site 983544006887 nucleotide binding site [chemical binding]; other site 983544006888 catalytic site [active] 983544006889 domain IV; other site 983544006890 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 983544006891 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 983544006892 pseudouridine synthase; Region: TIGR00093 983544006893 active site 983544006894 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 983544006895 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983544006896 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 983544006897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983544006898 Walker A/P-loop; other site 983544006899 ATP binding site [chemical binding]; other site 983544006900 Q-loop/lid; other site 983544006901 ABC transporter signature motif; other site 983544006902 Walker B; other site 983544006903 D-loop; other site 983544006904 H-loop/switch region; other site 983544006905 HlyD family secretion protein; Region: HlyD; pfam00529 983544006906 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 983544006907 HlyD family secretion protein; Region: HlyD_3; pfam13437 983544006908 Outer membrane efflux protein; Region: OEP; pfam02321 983544006909 Outer membrane efflux protein; Region: OEP; pfam02321 983544006910 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 983544006911 DNA-binding site [nucleotide binding]; DNA binding site 983544006912 RNA-binding motif; other site 983544006913 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 983544006914 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 983544006915 tetramer interface [polypeptide binding]; other site 983544006916 TPP-binding site [chemical binding]; other site 983544006917 heterodimer interface [polypeptide binding]; other site 983544006918 phosphorylation loop region [posttranslational modification] 983544006919 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 983544006920 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 983544006921 alpha subunit interface [polypeptide binding]; other site 983544006922 TPP binding site [chemical binding]; other site 983544006923 heterodimer interface [polypeptide binding]; other site 983544006924 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 983544006925 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 983544006926 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 983544006927 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 983544006928 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 983544006929 putative rRNA binding site [nucleotide binding]; other site 983544006930 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 983544006931 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 983544006932 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 983544006933 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 983544006934 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 983544006935 ligand binding site [chemical binding]; other site 983544006936 active site 983544006937 UGI interface [polypeptide binding]; other site 983544006938 catalytic site [active] 983544006939 Predicted membrane protein [Function unknown]; Region: COG1288 983544006940 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 983544006941 hypothetical protein; Provisional; Region: PRK06753 983544006942 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 983544006943 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 983544006944 human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs; Region: 17beta-HSDXI-like_SDR_c; cd05339 983544006945 putative NAD(P) binding site [chemical binding]; other site 983544006946 homodimer interface [polypeptide binding]; other site 983544006947 active site 983544006948 substrate binding site [chemical binding]; other site 983544006949 MutS domain III; Region: MutS_III; pfam05192 983544006950 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983544006951 Walker A/P-loop; other site 983544006952 ATP binding site [chemical binding]; other site 983544006953 Q-loop/lid; other site 983544006954 ABC transporter signature motif; other site 983544006955 Walker B; other site 983544006956 D-loop; other site 983544006957 H-loop/switch region; other site 983544006958 Protein of unknown function, DUF393; Region: DUF393; pfam04134 983544006959 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 983544006960 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 983544006961 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 983544006962 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 983544006963 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 983544006964 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 983544006965 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 983544006966 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 983544006967 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 983544006968 glutathione synthetase; Provisional; Region: PRK12458 983544006969 ATP-grasp domain; Region: ATP-grasp_4; cl17255 983544006970 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 983544006971 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 983544006972 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 983544006973 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 983544006974 active site residue [active] 983544006975 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 983544006976 active site residue [active] 983544006977 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 983544006978 glutathione synthetase; Provisional; Region: PRK12458 983544006979 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 983544006980 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 983544006981 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 983544006982 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 983544006983 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 983544006984 Tetramer interface [polypeptide binding]; other site 983544006985 active site 983544006986 FMN-binding site [chemical binding]; other site 983544006987 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 983544006988 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 983544006989 putative active site [active] 983544006990 putative metal binding site [ion binding]; other site 983544006991 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 983544006992 FAD binding domain; Region: FAD_binding_4; pfam01565 983544006993 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 983544006994 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 983544006995 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 983544006996 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 983544006997 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 983544006998 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 983544006999 Beta-lactamase; Region: Beta-lactamase; cl17358 983544007000 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 983544007001 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 983544007002 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 983544007003 phosphoserine phosphatase SerB; Region: serB; TIGR00338 983544007004 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983544007005 motif II; other site 983544007006 Predicted membrane protein [Function unknown]; Region: COG3428 983544007007 Bacterial PH domain; Region: DUF304; pfam03703 983544007008 Bacterial PH domain; Region: DUF304; pfam03703 983544007009 Bacterial PH domain; Region: DUF304; cl01348 983544007010 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 983544007011 Cysteine-rich domain; Region: CCG; pfam02754 983544007012 Cysteine-rich domain; Region: CCG; pfam02754 983544007013 4Fe-4S binding domain; Region: Fer4; cl02805 983544007014 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 983544007015 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 983544007016 mce related protein; Region: MCE; pfam02470 983544007017 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 983544007018 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 983544007019 active site 983544007020 metal binding site [ion binding]; metal-binding site 983544007021 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 983544007022 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 983544007023 homotrimer interaction site [polypeptide binding]; other site 983544007024 putative active site [active] 983544007025 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 983544007026 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 983544007027 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 983544007028 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 983544007029 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 983544007030 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 983544007031 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 983544007032 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 983544007033 6-phosphofructokinase; Provisional; Region: PRK03202 983544007034 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 983544007035 active site 983544007036 ADP/pyrophosphate binding site [chemical binding]; other site 983544007037 dimerization interface [polypeptide binding]; other site 983544007038 allosteric effector site; other site 983544007039 fructose-1,6-bisphosphate binding site; other site 983544007040 Family of unknown function (DUF490); Region: DUF490; pfam04357 983544007041 UGMP family protein; Validated; Region: PRK09604 983544007042 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 983544007043 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 983544007044 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 983544007045 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 983544007046 RNA methyltransferase, RsmE family; Region: TIGR00046 983544007047 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 983544007048 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 983544007049 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 983544007050 Domain of unknown function DUF20; Region: UPF0118; pfam01594 983544007051 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 983544007052 putative active site [active] 983544007053 putative metal binding site [ion binding]; other site 983544007054 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 983544007055 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983544007056 ATP binding site [chemical binding]; other site 983544007057 putative Mg++ binding site [ion binding]; other site 983544007058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983544007059 nucleotide binding region [chemical binding]; other site 983544007060 ATP-binding site [chemical binding]; other site 983544007061 DEAD/H associated; Region: DEAD_assoc; pfam08494 983544007062 ATP-dependent DNA ligase; Validated; Region: PRK09247 983544007063 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 983544007064 active site 983544007065 DNA binding site [nucleotide binding] 983544007066 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 983544007067 DNA binding site [nucleotide binding] 983544007068 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 983544007069 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 983544007070 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 983544007071 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983544007072 Zn2+ binding site [ion binding]; other site 983544007073 Mg2+ binding site [ion binding]; other site 983544007074 acetyl-CoA C-acetyltransferase; Region: PLN02644 983544007075 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983544007076 dimer interface [polypeptide binding]; other site 983544007077 active site 983544007078 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 983544007079 NlpC/P60 family; Region: NLPC_P60; pfam00877 983544007080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544007081 binding surface 983544007082 TPR motif; other site 983544007083 Tetratricopeptide repeat; Region: TPR_16; pfam13432 983544007084 Tetratricopeptide repeat; Region: TPR_16; pfam13432 983544007085 DNA gyrase subunit A; Validated; Region: PRK05560 983544007086 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 983544007087 CAP-like domain; other site 983544007088 active site 983544007089 primary dimer interface [polypeptide binding]; other site 983544007090 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983544007091 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983544007092 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983544007093 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983544007094 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983544007095 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983544007096 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 983544007097 Clp amino terminal domain; Region: Clp_N; pfam02861 983544007098 Clp amino terminal domain; Region: Clp_N; pfam02861 983544007099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983544007100 Walker A motif; other site 983544007101 ATP binding site [chemical binding]; other site 983544007102 Walker B motif; other site 983544007103 arginine finger; other site 983544007104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983544007105 Walker A motif; other site 983544007106 ATP binding site [chemical binding]; other site 983544007107 Walker B motif; other site 983544007108 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 983544007109 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 983544007110 active sites [active] 983544007111 tetramer interface [polypeptide binding]; other site 983544007112 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 983544007113 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 983544007114 catalytic residues [active] 983544007115 putative carbohydrate kinase; Provisional; Region: PRK10565 983544007116 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 983544007117 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 983544007118 putative substrate binding site [chemical binding]; other site 983544007119 putative ATP binding site [chemical binding]; other site 983544007120 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 983544007121 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 983544007122 putative catalytic residues [active] 983544007123 putative nucleotide binding site [chemical binding]; other site 983544007124 putative aspartate binding site [chemical binding]; other site 983544007125 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 983544007126 dimer interface [polypeptide binding]; other site 983544007127 putative threonine allosteric regulatory site; other site 983544007128 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 983544007129 putative threonine allosteric regulatory site; other site 983544007130 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 983544007131 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 983544007132 homoserine kinase; Provisional; Region: PRK01212 983544007133 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 983544007134 threonine synthase; Validated; Region: PRK09225 983544007135 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 983544007136 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983544007137 catalytic residue [active] 983544007138 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 983544007139 homodecamer interface [polypeptide binding]; other site 983544007140 GTP cyclohydrolase I; Provisional; Region: PLN03044 983544007141 active site 983544007142 putative catalytic site residues [active] 983544007143 zinc binding site [ion binding]; other site 983544007144 GTP-CH-I/GFRP interaction surface; other site 983544007145 methionine sulfoxide reductase A; Provisional; Region: PRK14054 983544007146 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 983544007147 putative ligand binding site [chemical binding]; other site 983544007148 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 983544007149 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 983544007150 Walker A/P-loop; other site 983544007151 ATP binding site [chemical binding]; other site 983544007152 Q-loop/lid; other site 983544007153 ABC transporter signature motif; other site 983544007154 Walker B; other site 983544007155 D-loop; other site 983544007156 H-loop/switch region; other site 983544007157 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 983544007158 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 983544007159 GAF domain; Region: GAF; pfam01590 983544007160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983544007161 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 983544007162 dimer interface [polypeptide binding]; other site 983544007163 phosphorylation site [posttranslational modification] 983544007164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544007165 ATP binding site [chemical binding]; other site 983544007166 Mg2+ binding site [ion binding]; other site 983544007167 G-X-G motif; other site 983544007168 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 983544007169 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 983544007170 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 983544007171 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 983544007172 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983544007173 active site 983544007174 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 983544007175 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 983544007176 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 983544007177 dihydroorotase; Validated; Region: pyrC; PRK09357 983544007178 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 983544007179 active site 983544007180 putative hydrolase; Provisional; Region: PRK11460 983544007181 Predicted esterase [General function prediction only]; Region: COG0400 983544007182 putative hydrolase; Provisional; Region: PRK02113 983544007183 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 983544007184 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 983544007185 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 983544007186 putative acyl-acceptor binding pocket; other site 983544007187 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 983544007188 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 983544007189 active site 983544007190 NAD binding site [chemical binding]; other site 983544007191 metal binding site [ion binding]; metal-binding site 983544007192 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 983544007193 Chloramphenicol acetyltransferase; Region: CAT; cl02008 983544007194 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 983544007195 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983544007196 motif II; other site 983544007197 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 983544007198 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 983544007199 Ligand binding site; other site 983544007200 oligomer interface; other site 983544007201 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 983544007202 AAA domain; Region: AAA_30; pfam13604 983544007203 Family description; Region: UvrD_C_2; pfam13538 983544007204 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 983544007205 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 983544007206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544007207 S-adenosylmethionine binding site [chemical binding]; other site 983544007208 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 983544007209 active site 983544007210 dinuclear metal binding site [ion binding]; other site 983544007211 dimerization interface [polypeptide binding]; other site 983544007212 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 983544007213 exopolyphosphatase; Region: exo_poly_only; TIGR03706 983544007214 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 983544007215 polyphosphate kinase; Provisional; Region: PRK05443 983544007216 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 983544007217 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 983544007218 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 983544007219 domain interface [polypeptide binding]; other site 983544007220 active site 983544007221 catalytic site [active] 983544007222 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 983544007223 domain interface [polypeptide binding]; other site 983544007224 active site 983544007225 catalytic site [active] 983544007226 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 983544007227 catalytic core [active] 983544007228 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 983544007229 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 983544007230 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983544007231 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 983544007232 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 983544007233 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983544007234 ligand binding site [chemical binding]; other site 983544007235 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 983544007236 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 983544007237 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 983544007238 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 983544007239 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 983544007240 ribonuclease Z; Reviewed; Region: PRK00055 983544007241 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 983544007242 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 983544007243 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 983544007244 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983544007245 active site 983544007246 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 983544007247 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 983544007248 RNA binding site [nucleotide binding]; other site 983544007249 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 983544007250 RNA binding site [nucleotide binding]; other site 983544007251 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 983544007252 RNA binding site [nucleotide binding]; other site 983544007253 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 983544007254 RNA binding site [nucleotide binding]; other site 983544007255 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 983544007256 RNA binding site [nucleotide binding]; other site 983544007257 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 983544007258 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 983544007259 cytidylate kinase; Provisional; Region: cmk; PRK00023 983544007260 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 983544007261 CMP-binding site; other site 983544007262 The sites determining sugar specificity; other site 983544007263 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 983544007264 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 983544007265 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 983544007266 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 983544007267 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 983544007268 Found in ATP-dependent protease La (LON); Region: LON; smart00464 983544007269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983544007270 Walker A motif; other site 983544007271 ATP binding site [chemical binding]; other site 983544007272 Walker B motif; other site 983544007273 arginine finger; other site 983544007274 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 983544007275 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 983544007276 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983544007277 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983544007278 DNA binding residues [nucleotide binding] 983544007279 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 983544007280 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 983544007281 Peptidase family M48; Region: Peptidase_M48; pfam01435 983544007282 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 983544007283 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 983544007284 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 983544007285 trimer interface [polypeptide binding]; other site 983544007286 active site 983544007287 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 983544007288 catalytic site [active] 983544007289 glycogen branching enzyme; Provisional; Region: PRK12313 983544007290 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 983544007291 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 983544007292 active site 983544007293 catalytic site [active] 983544007294 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 983544007295 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 983544007296 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 983544007297 ligand binding site; other site 983544007298 oligomer interface; other site 983544007299 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 983544007300 dimer interface [polypeptide binding]; other site 983544007301 N-terminal domain interface [polypeptide binding]; other site 983544007302 sulfate 1 binding site; other site 983544007303 glycogen synthase; Provisional; Region: glgA; PRK00654 983544007304 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 983544007305 ADP-binding pocket [chemical binding]; other site 983544007306 homodimer interface [polypeptide binding]; other site 983544007307 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 983544007308 SelR domain; Region: SelR; pfam01641 983544007309 methionine sulfoxide reductase B; Provisional; Region: PRK00222 983544007310 SelR domain; Region: SelR; pfam01641 983544007311 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 983544007312 DinB superfamily; Region: DinB_2; pfam12867 983544007313 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 983544007314 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983544007315 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 983544007316 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 983544007317 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983544007318 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 983544007319 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 983544007320 Dehydroquinase class II; Region: DHquinase_II; pfam01220 983544007321 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 983544007322 active site 983544007323 trimer interface [polypeptide binding]; other site 983544007324 dimer interface [polypeptide binding]; other site 983544007325 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 983544007326 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 983544007327 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 983544007328 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 983544007329 active site 983544007330 Int/Topo IB signature motif; other site 983544007331 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 983544007332 PAS fold; Region: PAS_3; pfam08447 983544007333 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 983544007334 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983544007335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544007336 ATP binding site [chemical binding]; other site 983544007337 Mg2+ binding site [ion binding]; other site 983544007338 G-X-G motif; other site 983544007339 phosphodiesterase; Provisional; Region: PRK12704 983544007340 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983544007341 Zn2+ binding site [ion binding]; other site 983544007342 Mg2+ binding site [ion binding]; other site 983544007343 Cell division protein ZapA; Region: ZapA; pfam05164 983544007344 Peptidase family M23; Region: Peptidase_M23; pfam01551 983544007345 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 983544007346 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544007347 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 983544007348 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 983544007349 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983544007350 active site 983544007351 DNA binding site [nucleotide binding] 983544007352 Int/Topo IB signature motif; other site 983544007353 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 983544007354 catalytic motif [active] 983544007355 Catalytic residue [active] 983544007356 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 983544007357 Helix-turn-helix domain; Region: HTH_18; pfam12833 983544007358 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983544007359 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 983544007360 classical (c) SDRs; Region: SDR_c; cd05233 983544007361 NAD(P) binding site [chemical binding]; other site 983544007362 active site 983544007363 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 983544007364 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 983544007365 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 983544007366 hydroxyglutarate oxidase; Provisional; Region: PRK11728 983544007367 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 983544007368 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 983544007369 phosphodiesterase YaeI; Provisional; Region: PRK11340 983544007370 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 983544007371 putative active site [active] 983544007372 putative metal binding site [ion binding]; other site 983544007373 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983544007374 dimerization interface [polypeptide binding]; other site 983544007375 putative DNA binding site [nucleotide binding]; other site 983544007376 putative Zn2+ binding site [ion binding]; other site 983544007377 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 983544007378 putative NAD(P) binding site [chemical binding]; other site 983544007379 homodimer interface [polypeptide binding]; other site 983544007380 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 983544007381 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 983544007382 dimer interface [polypeptide binding]; other site 983544007383 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 983544007384 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983544007385 dimer interface [polypeptide binding]; other site 983544007386 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 983544007387 homotrimer interaction site [polypeptide binding]; other site 983544007388 putative active site [active] 983544007389 Helix-turn-helix domain; Region: HTH_18; pfam12833 983544007390 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983544007391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983544007392 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983544007393 putative substrate translocation pore; other site 983544007394 short chain dehydrogenase; Provisional; Region: PRK06197 983544007395 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 983544007396 putative NAD(P) binding site [chemical binding]; other site 983544007397 active site 983544007398 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 983544007399 hydrophobic ligand binding site; other site 983544007400 Cupin domain; Region: Cupin_2; cl17218 983544007401 hypothetical protein; Provisional; Region: 30.2; PHA02597 983544007402 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 983544007403 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 983544007404 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 983544007405 arsenical-resistance protein; Region: acr3; TIGR00832 983544007406 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983544007407 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983544007408 Predicted transcriptional regulators [Transcription]; Region: COG1733 983544007409 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 983544007410 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983544007411 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983544007412 active site 983544007413 metal binding site [ion binding]; metal-binding site 983544007414 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 983544007415 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 983544007416 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 983544007417 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983544007418 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983544007419 N-terminal plug; other site 983544007420 ligand-binding site [chemical binding]; other site 983544007421 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983544007422 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 983544007423 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 983544007424 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983544007425 catalytic residue [active] 983544007426 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 983544007427 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544007428 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 983544007429 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 983544007430 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 983544007431 inhibitor-cofactor binding pocket; inhibition site 983544007432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983544007433 catalytic residue [active] 983544007434 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 983544007435 TRAM domain; Region: TRAM; cl01282 983544007436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544007437 S-adenosylmethionine binding site [chemical binding]; other site 983544007438 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 983544007439 DinB superfamily; Region: DinB_2; pfam12867 983544007440 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 983544007441 active site 983544007442 catalytic site [active] 983544007443 lipid A phosphoethanolamine transferase; Reviewed; Region: PRK09598 983544007444 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 983544007445 Sulfatase; Region: Sulfatase; pfam00884 983544007446 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 983544007447 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 983544007448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544007449 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 983544007450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544007451 S-adenosylmethionine binding site [chemical binding]; other site 983544007452 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 983544007453 Haemolysin-III related; Region: HlyIII; cl03831 983544007454 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 983544007455 Domain of unknown function (DUF4294); Region: DUF4294; pfam14127 983544007456 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 983544007457 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 983544007458 oligomer interface [polypeptide binding]; other site 983544007459 active site 983544007460 metal binding site [ion binding]; metal-binding site 983544007461 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 983544007462 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983544007463 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983544007464 catalytic residue [active] 983544007465 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 983544007466 nudix motif; other site 983544007467 Protease prsW family; Region: PrsW-protease; pfam13367 983544007468 MarC family integral membrane protein; Region: MarC; cl00919 983544007469 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 983544007470 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 983544007471 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 983544007472 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 983544007473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983544007474 Walker A/P-loop; other site 983544007475 ATP binding site [chemical binding]; other site 983544007476 Q-loop/lid; other site 983544007477 ABC transporter signature motif; other site 983544007478 Walker B; other site 983544007479 D-loop; other site 983544007480 H-loop/switch region; other site 983544007481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983544007482 putative substrate translocation pore; other site 983544007483 CsbD-like; Region: CsbD; pfam05532 983544007484 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 983544007485 active site 983544007486 nucleophile elbow; other site 983544007487 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 983544007488 Fatty acid desaturase; Region: FA_desaturase; pfam00487 983544007489 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 983544007490 putative di-iron ligands [ion binding]; other site 983544007491 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 983544007492 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 983544007493 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983544007494 ligand binding site [chemical binding]; other site 983544007495 flexible hinge region; other site 983544007496 YceI-like domain; Region: YceI; pfam04264 983544007497 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 983544007498 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983544007499 ligand binding site [chemical binding]; other site 983544007500 flexible hinge region; other site 983544007501 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 983544007502 Beta-lactamase; Region: Beta-lactamase; pfam00144 983544007503 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983544007504 binding surface 983544007505 TPR repeat; Region: TPR_11; pfam13414 983544007506 TPR motif; other site 983544007507 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 983544007508 acetyl-CoA synthetase; Provisional; Region: PRK00174 983544007509 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 983544007510 active site 983544007511 CoA binding site [chemical binding]; other site 983544007512 acyl-activating enzyme (AAE) consensus motif; other site 983544007513 AMP binding site [chemical binding]; other site 983544007514 acetate binding site [chemical binding]; other site 983544007515 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 983544007516 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 983544007517 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983544007518 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983544007519 Uncharacterized conserved protein [Function unknown]; Region: COG2128 983544007520 short chain dehydrogenase; Validated; Region: PRK08264 983544007521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983544007522 NAD(P) binding site [chemical binding]; other site 983544007523 active site 983544007524 EthD domain; Region: EthD; cl17553 983544007525 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 983544007526 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 983544007527 catalytic residues [active] 983544007528 Major royal jelly protein; Region: MRJP; pfam03022 983544007529 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 983544007530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983544007531 motif II; other site 983544007532 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 983544007533 ATP binding site [chemical binding]; other site 983544007534 active site 983544007535 substrate binding site [chemical binding]; other site 983544007536 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 983544007537 PhoH-like protein; Region: PhoH; pfam02562 983544007538 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 983544007539 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 983544007540 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 983544007541 short chain dehydrogenase; Provisional; Region: PRK06181 983544007542 NADP binding site [chemical binding]; other site 983544007543 homodimer interface [polypeptide binding]; other site 983544007544 substrate binding site [chemical binding]; other site 983544007545 active site 983544007546 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 983544007547 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 983544007548 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 983544007549 DNA polymerase III subunit beta; Validated; Region: PRK05643 983544007550 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 983544007551 putative DNA binding surface [nucleotide binding]; other site 983544007552 dimer interface [polypeptide binding]; other site 983544007553 beta-clamp/clamp loader binding surface; other site 983544007554 beta-clamp/translesion DNA polymerase binding surface; other site 983544007555 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544007556 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 983544007557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544007558 active site 983544007559 phosphorylation site [posttranslational modification] 983544007560 intermolecular recognition site; other site 983544007561 dimerization interface [polypeptide binding]; other site 983544007562 LytTr DNA-binding domain; Region: LytTR; smart00850 983544007563 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 983544007564 Histidine kinase; Region: His_kinase; pfam06580 983544007565 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 983544007566 Tic20-like protein; Region: Tic20; pfam09685 983544007567 Sulphur transport; Region: Sulf_transp; pfam04143 983544007568 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 983544007569 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 983544007570 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 983544007571 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 983544007572 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 983544007573 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 983544007574 active site residue [active] 983544007575 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 983544007576 active site residue [active] 983544007577 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 983544007578 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 983544007579 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983544007580 ligand binding site [chemical binding]; other site 983544007581 flexible hinge region; other site 983544007582 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 983544007583 putative switch regulator; other site 983544007584 non-specific DNA interactions [nucleotide binding]; other site 983544007585 DNA binding site [nucleotide binding] 983544007586 sequence specific DNA binding site [nucleotide binding]; other site 983544007587 putative cAMP binding site [chemical binding]; other site 983544007588 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 983544007589 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983544007590 motif II; other site 983544007591 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 983544007592 GAF domain; Region: GAF; pfam01590 983544007593 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983544007594 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983544007595 dimer interface [polypeptide binding]; other site 983544007596 phosphorylation site [posttranslational modification] 983544007597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544007598 ATP binding site [chemical binding]; other site 983544007599 Mg2+ binding site [ion binding]; other site 983544007600 G-X-G motif; other site 983544007601 Response regulator receiver domain; Region: Response_reg; pfam00072 983544007602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544007603 active site 983544007604 phosphorylation site [posttranslational modification] 983544007605 intermolecular recognition site; other site 983544007606 dimerization interface [polypeptide binding]; other site 983544007607 PAS domain; Region: PAS_9; pfam13426 983544007608 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544007609 putative active site [active] 983544007610 heme pocket [chemical binding]; other site 983544007611 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 983544007612 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544007613 putative active site [active] 983544007614 heme pocket [chemical binding]; other site 983544007615 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983544007616 dimer interface [polypeptide binding]; other site 983544007617 phosphorylation site [posttranslational modification] 983544007618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544007619 ATP binding site [chemical binding]; other site 983544007620 Mg2+ binding site [ion binding]; other site 983544007621 G-X-G motif; other site 983544007622 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983544007623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544007624 active site 983544007625 phosphorylation site [posttranslational modification] 983544007626 intermolecular recognition site; other site 983544007627 dimerization interface [polypeptide binding]; other site 983544007628 GAF domain; Region: GAF_2; pfam13185 983544007629 PAS domain S-box; Region: sensory_box; TIGR00229 983544007630 PAS domain S-box; Region: sensory_box; TIGR00229 983544007631 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544007632 putative active site [active] 983544007633 heme pocket [chemical binding]; other site 983544007634 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544007635 putative active site [active] 983544007636 PAS fold; Region: PAS_3; pfam08447 983544007637 heme pocket [chemical binding]; other site 983544007638 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544007639 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 983544007640 putative active site [active] 983544007641 heme pocket [chemical binding]; other site 983544007642 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544007643 PAS domain; Region: PAS_9; pfam13426 983544007644 putative active site [active] 983544007645 heme pocket [chemical binding]; other site 983544007646 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 983544007647 GAF domain; Region: GAF; pfam01590 983544007648 PAS domain S-box; Region: sensory_box; TIGR00229 983544007649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544007650 putative active site [active] 983544007651 heme pocket [chemical binding]; other site 983544007652 GAF domain; Region: GAF; pfam01590 983544007653 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 983544007654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983544007655 Walker A motif; other site 983544007656 ATP binding site [chemical binding]; other site 983544007657 Walker B motif; other site 983544007658 arginine finger; other site 983544007659 Response regulator receiver domain; Region: Response_reg; pfam00072 983544007660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544007661 active site 983544007662 phosphorylation site [posttranslational modification] 983544007663 intermolecular recognition site; other site 983544007664 dimerization interface [polypeptide binding]; other site 983544007665 PAS fold; Region: PAS_4; pfam08448 983544007666 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544007667 putative active site [active] 983544007668 heme pocket [chemical binding]; other site 983544007669 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544007670 PAS domain; Region: PAS_9; pfam13426 983544007671 putative active site [active] 983544007672 heme pocket [chemical binding]; other site 983544007673 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544007674 PAS fold; Region: PAS_3; pfam08447 983544007675 putative active site [active] 983544007676 heme pocket [chemical binding]; other site 983544007677 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544007678 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 983544007679 putative active site [active] 983544007680 heme pocket [chemical binding]; other site 983544007681 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544007682 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 983544007683 putative active site [active] 983544007684 heme pocket [chemical binding]; other site 983544007685 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544007686 putative active site [active] 983544007687 heme pocket [chemical binding]; other site 983544007688 PAS fold; Region: PAS_4; pfam08448 983544007689 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544007690 putative active site [active] 983544007691 heme pocket [chemical binding]; other site 983544007692 PAS domain S-box; Region: sensory_box; TIGR00229 983544007693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983544007694 dimer interface [polypeptide binding]; other site 983544007695 phosphorylation site [posttranslational modification] 983544007696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544007697 ATP binding site [chemical binding]; other site 983544007698 Mg2+ binding site [ion binding]; other site 983544007699 G-X-G motif; other site 983544007700 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 983544007701 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248 983544007702 substrate binding site [chemical binding]; other site 983544007703 dimerization interface [polypeptide binding]; other site 983544007704 active site 983544007705 calcium binding site [ion binding]; other site 983544007706 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 983544007707 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 983544007708 Transposase; Region: HTH_Tnp_1; cl17663 983544007709 putative transposase OrfB; Reviewed; Region: PHA02517 983544007710 Integrase core domain; Region: rve; pfam00665 983544007711 Integrase core domain; Region: rve_3; pfam13683 983544007712 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 983544007713 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 983544007714 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 983544007715 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 983544007716 trmE is a tRNA modification GTPase; Region: trmE; cd04164 983544007717 G1 box; other site 983544007718 GTP/Mg2+ binding site [chemical binding]; other site 983544007719 Switch I region; other site 983544007720 G2 box; other site 983544007721 Switch II region; other site 983544007722 G3 box; other site 983544007723 G4 box; other site 983544007724 G5 box; other site 983544007725 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 983544007726 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 983544007727 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 983544007728 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 983544007729 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 983544007730 putative acyl-acceptor binding pocket; other site 983544007731 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 983544007732 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983544007733 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983544007734 catalytic residue [active] 983544007735 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 983544007736 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 983544007737 active site 983544007738 substrate binding site [chemical binding]; other site 983544007739 metal binding site [ion binding]; metal-binding site 983544007740 Protein of unknown function, DUF479; Region: DUF479; cl01203 983544007741 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 983544007742 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 983544007743 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 983544007744 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 983544007745 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 983544007746 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 983544007747 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 983544007748 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 983544007749 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 983544007750 tetramer interface [polypeptide binding]; other site 983544007751 TPP-binding site [chemical binding]; other site 983544007752 heterodimer interface [polypeptide binding]; other site 983544007753 phosphorylation loop region [posttranslational modification] 983544007754 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 983544007755 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 983544007756 PYR/PP interface [polypeptide binding]; other site 983544007757 dimer interface [polypeptide binding]; other site 983544007758 TPP binding site [chemical binding]; other site 983544007759 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 983544007760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 983544007761 AAA domain; Region: AAA_33; pfam13671 983544007762 AAA domain; Region: AAA_17; pfam13207 983544007763 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 983544007764 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 983544007765 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 983544007766 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 983544007767 intracellular protease, PfpI family; Region: PfpI; TIGR01382 983544007768 proposed catalytic triad [active] 983544007769 conserved cys residue [active] 983544007770 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 983544007771 DNA polymerase III, delta subunit; Region: holA; TIGR01128 983544007772 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 983544007773 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 983544007774 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 983544007775 Probable Catalytic site; other site 983544007776 metal-binding site 983544007777 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 983544007778 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983544007779 ligand binding site [chemical binding]; other site 983544007780 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 983544007781 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 983544007782 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 983544007783 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 983544007784 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 983544007785 Part of AAA domain; Region: AAA_19; pfam13245 983544007786 Family description; Region: UvrD_C_2; pfam13538 983544007787 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983544007788 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983544007789 DNA binding residues [nucleotide binding] 983544007790 dimerization interface [polypeptide binding]; other site 983544007791 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 983544007792 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 983544007793 active site 983544007794 FMN binding site [chemical binding]; other site 983544007795 substrate binding site [chemical binding]; other site 983544007796 3Fe-4S cluster binding site [ion binding]; other site 983544007797 Patatin-like phospholipase; Region: Patatin; pfam01734 983544007798 active site 983544007799 nucleophile elbow; other site 983544007800 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 983544007801 Zn binding site [ion binding]; other site 983544007802 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 983544007803 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 983544007804 generic binding surface II; other site 983544007805 ssDNA binding site; other site 983544007806 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983544007807 ATP binding site [chemical binding]; other site 983544007808 putative Mg++ binding site [ion binding]; other site 983544007809 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983544007810 nucleotide binding region [chemical binding]; other site 983544007811 ATP-binding site [chemical binding]; other site 983544007812 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 983544007813 active site 983544007814 dinuclear metal binding site [ion binding]; other site 983544007815 dimerization interface [polypeptide binding]; other site 983544007816 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 983544007817 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 983544007818 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983544007819 non-specific DNA binding site [nucleotide binding]; other site 983544007820 salt bridge; other site 983544007821 sequence-specific DNA binding site [nucleotide binding]; other site 983544007822 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 983544007823 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983544007824 non-specific DNA binding site [nucleotide binding]; other site 983544007825 salt bridge; other site 983544007826 sequence-specific DNA binding site [nucleotide binding]; other site 983544007827 DNA methylase; Region: N6_N4_Mtase; cl17433 983544007828 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 983544007829 VirE N-terminal domain; Region: VirE_N; pfam08800 983544007830 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 983544007831 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 983544007832 Helix-turn-helix domain; Region: HTH_17; pfam12728 983544007833 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 983544007834 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983544007835 active site 983544007836 DNA binding site [nucleotide binding] 983544007837 Int/Topo IB signature motif; other site 983544007838 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 983544007839 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983544007840 non-specific DNA binding site [nucleotide binding]; other site 983544007841 salt bridge; other site 983544007842 sequence-specific DNA binding site [nucleotide binding]; other site 983544007843 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 983544007844 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 983544007845 Transposase; Region: HTH_Tnp_1; cl17663 983544007846 putative transposase OrfB; Reviewed; Region: PHA02517 983544007847 Integrase core domain; Region: rve; pfam00665 983544007848 Integrase core domain; Region: rve_3; pfam13683 983544007849 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 983544007850 oxidoreductase, 2OG-Fe(II) oxygenase family protein; Region: PLN02758 983544007851 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 983544007852 Transposase; Region: HTH_Tnp_1; cl17663 983544007853 putative transposase OrfB; Reviewed; Region: PHA02517 983544007854 Integrase core domain; Region: rve; pfam00665 983544007855 Integrase core domain; Region: rve_3; pfam13683 983544007856 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 983544007857 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 983544007858 BCCT family transporter; Region: BCCT; cl00569 983544007859 Domain of unknown function (DUF305); Region: DUF305; cl17794 983544007860 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 983544007861 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 983544007862 catalytic residues [active] 983544007863 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 983544007864 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 983544007865 putative tRNA-binding site [nucleotide binding]; other site 983544007866 B3/4 domain; Region: B3_4; pfam03483 983544007867 tRNA synthetase B5 domain; Region: B5; pfam03484 983544007868 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 983544007869 dimer interface [polypeptide binding]; other site 983544007870 motif 1; other site 983544007871 motif 3; other site 983544007872 motif 2; other site 983544007873 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 983544007874 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 983544007875 active site 983544007876 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 983544007877 Fasciclin domain; Region: Fasciclin; pfam02469 983544007878 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 983544007879 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 983544007880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983544007881 Walker A/P-loop; other site 983544007882 ATP binding site [chemical binding]; other site 983544007883 Q-loop/lid; other site 983544007884 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983544007885 ABC transporter signature motif; other site 983544007886 Walker B; other site 983544007887 D-loop; other site 983544007888 ABC transporter; Region: ABC_tran_2; pfam12848 983544007889 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983544007890 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983544007891 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 983544007892 active site 983544007893 intersubunit interactions; other site 983544007894 catalytic residue [active] 983544007895 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 983544007896 NADP binding site [chemical binding]; other site 983544007897 short chain dehydrogenase; Provisional; Region: PRK06914 983544007898 active site 983544007899 steroid binding site; other site 983544007900 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 983544007901 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 983544007902 active site 983544007903 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 983544007904 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 983544007905 dimer interface [polypeptide binding]; other site 983544007906 active site 983544007907 glycine-pyridoxal phosphate binding site [chemical binding]; other site 983544007908 folate binding site [chemical binding]; other site 983544007909 fumarylacetoacetase; Region: PLN02856 983544007910 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 983544007911 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 983544007912 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 983544007913 Response regulator receiver domain; Region: Response_reg; pfam00072 983544007914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544007915 active site 983544007916 phosphorylation site [posttranslational modification] 983544007917 intermolecular recognition site; other site 983544007918 dimerization interface [polypeptide binding]; other site 983544007919 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 983544007920 PAS fold; Region: PAS_4; pfam08448 983544007921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544007922 putative active site [active] 983544007923 heme pocket [chemical binding]; other site 983544007924 PAS fold; Region: PAS_3; pfam08447 983544007925 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 983544007926 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983544007927 putative active site [active] 983544007928 heme pocket [chemical binding]; other site 983544007929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544007930 ATP binding site [chemical binding]; other site 983544007931 Mg2+ binding site [ion binding]; other site 983544007932 G-X-G motif; other site 983544007933 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 983544007934 Clp amino terminal domain; Region: Clp_N; pfam02861 983544007935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983544007936 Walker A motif; other site 983544007937 ATP binding site [chemical binding]; other site 983544007938 Walker B motif; other site 983544007939 arginine finger; other site 983544007940 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 983544007941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983544007942 Walker A motif; other site 983544007943 ATP binding site [chemical binding]; other site 983544007944 Walker B motif; other site 983544007945 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 983544007946 malate:quinone oxidoreductase; Validated; Region: PRK05257 983544007947 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 983544007948 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 983544007949 catalytic core [active] 983544007950 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 983544007951 SmpB-tmRNA interface; other site 983544007952 Cna protein B-type domain; Region: Cna_B_2; pfam13715 983544007953 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 983544007954 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 983544007955 Methyltransferase domain; Region: Methyltransf_18; pfam12847 983544007956 S-adenosylmethionine binding site [chemical binding]; other site 983544007957 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 983544007958 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 983544007959 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 983544007960 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 983544007961 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 983544007962 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983544007963 Uncharacterized conserved protein [Function unknown]; Region: COG4198 983544007964 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 983544007965 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 983544007966 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 983544007967 catalytic residue [active] 983544007968 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 983544007969 active site 983544007970 catalytic site [active] 983544007971 substrate binding site [chemical binding]; other site 983544007972 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 983544007973 GIY-YIG motif/motif A; other site 983544007974 active site 983544007975 catalytic site [active] 983544007976 putative DNA binding site [nucleotide binding]; other site 983544007977 metal binding site [ion binding]; metal-binding site 983544007978 Ion transport protein; Region: Ion_trans; pfam00520 983544007979 Ion channel; Region: Ion_trans_2; pfam07885 983544007980 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 983544007981 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 983544007982 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 983544007983 Predicted membrane protein [Function unknown]; Region: COG4325 983544007984 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 983544007985 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983544007986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983544007987 active site 983544007988 phosphorylation site [posttranslational modification] 983544007989 intermolecular recognition site; other site 983544007990 dimerization interface [polypeptide binding]; other site 983544007991 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983544007992 DNA binding site [nucleotide binding] 983544007993 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983544007994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983544007995 dimer interface [polypeptide binding]; other site 983544007996 phosphorylation site [posttranslational modification] 983544007997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983544007998 ATP binding site [chemical binding]; other site 983544007999 Mg2+ binding site [ion binding]; other site 983544008000 G-X-G motif; other site 983544008001 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 983544008002 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 983544008003 CoA-binding site [chemical binding]; other site 983544008004 ATP-binding [chemical binding]; other site 983544008005 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 983544008006 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 983544008007 active site 983544008008 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 983544008009 Interdomain contacts; other site 983544008010 Cytokine receptor motif; other site 983544008011 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 983544008012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983544008013 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 983544008014 NAD(P) binding site [chemical binding]; other site 983544008015 active site 983544008016 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 983544008017 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 983544008018 Walker A/P-loop; other site 983544008019 ATP binding site [chemical binding]; other site 983544008020 Q-loop/lid; other site 983544008021 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 983544008022 ABC transporter signature motif; other site 983544008023 Walker B; other site 983544008024 D-loop; other site 983544008025 H-loop/switch region; other site 983544008026 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 983544008027 Flavoprotein; Region: Flavoprotein; pfam02441 983544008028 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 983544008029 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 983544008030 Outer membrane lipoprotein; Region: YfiO; pfam13525 983544008031 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 983544008032 dihydrodipicolinate synthase; Region: dapA; TIGR00674 983544008033 dimer interface [polypeptide binding]; other site 983544008034 active site 983544008035 catalytic residue [active] 983544008036 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 983544008037 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 983544008038 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 983544008039 active site 983544008040 metal binding site [ion binding]; metal-binding site 983544008041 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 983544008042 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 983544008043 nucleotide binding pocket [chemical binding]; other site 983544008044 K-X-D-G motif; other site 983544008045 catalytic site [active] 983544008046 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 983544008047 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 983544008048 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 983544008049 Dimer interface [polypeptide binding]; other site 983544008050 BRCT sequence motif; other site 983544008051 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 983544008052 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 983544008053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983544008054 S-adenosylmethionine binding site [chemical binding]; other site 983544008055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983544008056 Coenzyme A binding pocket [chemical binding]; other site 983544008057 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 983544008058 catalytic motif [active] 983544008059 Zn binding site [ion binding]; other site 983544008060 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 983544008061 RibD C-terminal domain; Region: RibD_C; cl17279 983544008062 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 983544008063 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 983544008064 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 983544008065 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 983544008066 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 983544008067 active site