-- dump date 20140619_120036 -- class Genbank::misc_feature -- table misc_feature_note -- id note 710696000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 710696000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696000003 Walker A motif; other site 710696000004 ATP binding site [chemical binding]; other site 710696000005 Walker B motif; other site 710696000006 arginine finger; other site 710696000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 710696000008 DnaA box-binding interface [nucleotide binding]; other site 710696000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 710696000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 710696000011 putative DNA binding surface [nucleotide binding]; other site 710696000012 dimer interface [polypeptide binding]; other site 710696000013 beta-clamp/clamp loader binding surface; other site 710696000014 beta-clamp/translesion DNA polymerase binding surface; other site 710696000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 710696000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710696000017 recombination protein F; Reviewed; Region: recF; PRK00064 710696000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 710696000019 Walker A/P-loop; other site 710696000020 ATP binding site [chemical binding]; other site 710696000021 Q-loop/lid; other site 710696000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696000023 ABC transporter signature motif; other site 710696000024 Walker B; other site 710696000025 D-loop; other site 710696000026 H-loop/switch region; other site 710696000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 710696000028 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 710696000029 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 710696000030 active site 710696000031 Zn binding site [ion binding]; other site 710696000032 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 710696000033 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696000034 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710696000035 DNA binding residues [nucleotide binding] 710696000036 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 710696000037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696000038 Mg2+ binding site [ion binding]; other site 710696000039 G-X-G motif; other site 710696000040 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 710696000041 anchoring element; other site 710696000042 dimer interface [polypeptide binding]; other site 710696000043 ATP binding site [chemical binding]; other site 710696000044 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 710696000045 active site 710696000046 putative metal-binding site [ion binding]; other site 710696000047 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 710696000048 DNA gyrase subunit A; Validated; Region: PRK05560 710696000049 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 710696000050 CAP-like domain; other site 710696000051 active site 710696000052 primary dimer interface [polypeptide binding]; other site 710696000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710696000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710696000055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710696000056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710696000057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710696000058 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 710696000059 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 710696000060 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710696000061 active site 710696000062 DNA binding site [nucleotide binding] 710696000063 Int/Topo IB signature motif; other site 710696000064 Helix-turn-helix domain; Region: HTH_17; cl17695 710696000065 Transcription factor WhiB; Region: Whib; pfam02467 710696000066 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710696000067 H+ Antiporter protein; Region: 2A0121; TIGR00900 710696000068 Domain of unknown function (DUF397); Region: DUF397; pfam04149 710696000069 Predicted transcriptional regulator with C-terminal CBS domains [Transcription]; Region: COG3620 710696000070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710696000071 non-specific DNA binding site [nucleotide binding]; other site 710696000072 salt bridge; other site 710696000073 sequence-specific DNA binding site [nucleotide binding]; other site 710696000074 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710696000075 NlpC/P60 family; Region: NLPC_P60; pfam00877 710696000076 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 710696000077 AAA-like domain; Region: AAA_10; pfam12846 710696000078 peptide synthase; Validated; Region: PRK05691 710696000079 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710696000080 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710696000081 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 710696000082 Winged helix-turn helix; Region: HTH_29; pfam13551 710696000083 DNA-binding interface [nucleotide binding]; DNA binding site 710696000084 Homeodomain-like domain; Region: HTH_32; pfam13565 710696000085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 710696000086 Integrase core domain; Region: rve; pfam00665 710696000087 Integrase core domain; Region: rve_3; pfam13683 710696000088 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 710696000089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696000090 Walker A motif; other site 710696000091 ATP binding site [chemical binding]; other site 710696000092 Walker B motif; other site 710696000093 arginine finger; other site 710696000094 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 710696000095 DNA methylase; Region: N6_N4_Mtase; pfam01555 710696000096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696000097 S-adenosylmethionine binding site [chemical binding]; other site 710696000098 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 710696000099 Protein of unknown function DUF262; Region: DUF262; pfam03235 710696000100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710696000101 non-specific DNA binding site [nucleotide binding]; other site 710696000102 salt bridge; other site 710696000103 sequence-specific DNA binding site [nucleotide binding]; other site 710696000104 HipA N-terminal domain; Region: Couple_hipA; cl11853 710696000105 HipA-like N-terminal domain; Region: HipA_N; pfam07805 710696000106 HipA-like C-terminal domain; Region: HipA_C; pfam07804 710696000107 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710696000108 Predicted membrane protein [Function unknown]; Region: COG2259 710696000109 Archaebacterial flagellin; Region: Arch_flagellin; cl00732 710696000110 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 710696000111 Thioredoxin; Region: Thioredoxin_4; pfam13462 710696000112 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 710696000113 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 710696000114 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 710696000115 Cysteine-rich domain; Region: CCG; pfam02754 710696000116 FAD binding domain; Region: FAD_binding_4; pfam01565 710696000117 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 710696000118 L-lactate permease; Region: Lactate_perm; cl00701 710696000119 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 710696000120 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 710696000121 L-lactate permease; Region: Lactate_perm; cl00701 710696000122 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710696000123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710696000124 DNA-binding site [nucleotide binding]; DNA binding site 710696000125 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 710696000126 Caspase domain; Region: Peptidase_C14; pfam00656 710696000127 Predicted membrane protein [Function unknown]; Region: COG3428 710696000128 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 710696000129 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 710696000130 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 710696000131 active site 710696000132 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 710696000133 Rhomboid family; Region: Rhomboid; pfam01694 710696000134 putative septation inhibitor protein; Reviewed; Region: PRK02251 710696000135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 710696000136 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 710696000137 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 710696000138 Glutamine amidotransferase class-I; Region: GATase; pfam00117 710696000139 glutamine binding [chemical binding]; other site 710696000140 catalytic triad [active] 710696000141 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710696000142 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710696000143 active site 710696000144 ATP binding site [chemical binding]; other site 710696000145 substrate binding site [chemical binding]; other site 710696000146 activation loop (A-loop); other site 710696000147 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710696000148 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710696000149 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710696000150 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710696000151 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710696000152 active site 710696000153 ATP binding site [chemical binding]; other site 710696000154 substrate binding site [chemical binding]; other site 710696000155 activation loop (A-loop); other site 710696000156 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 710696000157 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 710696000158 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 710696000159 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 710696000160 active site 710696000161 Protein phosphatase 2C; Region: PP2C; pfam00481 710696000162 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710696000163 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710696000164 phosphopeptide binding site; other site 710696000165 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 710696000166 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710696000167 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710696000168 phosphopeptide binding site; other site 710696000169 AAA domain; Region: AAA_31; pfam13614 710696000170 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 710696000171 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 710696000172 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 710696000173 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 710696000174 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710696000175 Transcriptional regulators [Transcription]; Region: PurR; COG1609 710696000176 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 710696000177 DNA binding site [nucleotide binding] 710696000178 domain linker motif; other site 710696000179 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 710696000180 dimerization interface [polypeptide binding]; other site 710696000181 ligand binding site [chemical binding]; other site 710696000182 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 710696000183 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 710696000184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696000185 dimer interface [polypeptide binding]; other site 710696000186 conserved gate region; other site 710696000187 putative PBP binding loops; other site 710696000188 ABC-ATPase subunit interface; other site 710696000189 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710696000190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696000191 dimer interface [polypeptide binding]; other site 710696000192 conserved gate region; other site 710696000193 putative PBP binding loops; other site 710696000194 ABC-ATPase subunit interface; other site 710696000195 DinB superfamily; Region: DinB_2; pfam12867 710696000196 Protein of unknown function (DUF664); Region: DUF664; pfam04978 710696000197 CAAX protease self-immunity; Region: Abi; pfam02517 710696000198 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710696000199 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 710696000200 substrate binding site [chemical binding]; other site 710696000201 ATP binding site [chemical binding]; other site 710696000202 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 710696000203 N-acetyl-D-glucosamine binding site [chemical binding]; other site 710696000204 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 710696000205 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 710696000206 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 710696000207 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 710696000208 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 710696000209 Active Sites [active] 710696000210 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 710696000211 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 710696000212 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 710696000213 active site 710696000214 SAM binding site [chemical binding]; other site 710696000215 homodimer interface [polypeptide binding]; other site 710696000216 Phosphotransferase enzyme family; Region: APH; pfam01636 710696000217 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 710696000218 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 710696000219 substrate binding site [chemical binding]; other site 710696000220 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 710696000221 metal ion-dependent adhesion site (MIDAS); other site 710696000222 Uncharacterized conserved protein [Function unknown]; Region: COG3287 710696000223 Putative zinc-finger; Region: zf-HC2; pfam13490 710696000224 putative anti-sigmaE protein; Provisional; Region: PRK13920 710696000225 Anti-sigma-K factor rskA; Region: RskA; pfam10099 710696000226 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 710696000227 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696000228 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710696000229 DNA binding residues [nucleotide binding] 710696000230 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 710696000231 Fasciclin domain; Region: Fasciclin; pfam02469 710696000232 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 710696000233 Moco binding site; other site 710696000234 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 710696000235 metal coordination site [ion binding]; other site 710696000236 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710696000237 hydrophobic ligand binding site; other site 710696000238 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710696000239 YCII-related domain; Region: YCII; cl00999 710696000240 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 710696000241 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 710696000242 conserved cys residue [active] 710696000243 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 710696000244 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 710696000245 Putative esterase; Region: Esterase; pfam00756 710696000246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 710696000247 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 710696000248 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 710696000249 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 710696000250 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 710696000251 Ligand binding site; other site 710696000252 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710696000253 MoxR-like ATPases [General function prediction only]; Region: COG0714 710696000254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696000255 Walker A motif; other site 710696000256 ATP binding site [chemical binding]; other site 710696000257 Walker B motif; other site 710696000258 arginine finger; other site 710696000259 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 710696000260 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 710696000261 metal ion-dependent adhesion site (MIDAS); other site 710696000262 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 710696000263 XdhC Rossmann domain; Region: XdhC_C; pfam13478 710696000264 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710696000265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696000266 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710696000267 active site 710696000268 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710696000269 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710696000270 active site 710696000271 catalytic tetrad [active] 710696000272 H+ Antiporter protein; Region: 2A0121; TIGR00900 710696000273 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696000274 putative DNA binding site [nucleotide binding]; other site 710696000275 putative Zn2+ binding site [ion binding]; other site 710696000276 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 710696000277 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 710696000278 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 710696000279 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 710696000280 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 710696000281 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 710696000282 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 710696000283 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 710696000284 putative hydrophobic ligand binding site [chemical binding]; other site 710696000285 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 710696000286 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 710696000287 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 710696000288 active site 710696000289 catalytic site [active] 710696000290 benzoate transport; Region: 2A0115; TIGR00895 710696000291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696000292 putative substrate translocation pore; other site 710696000293 Hemerythrin-like domain; Region: Hr-like; cd12108 710696000294 Fe binding site [ion binding]; other site 710696000295 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 710696000296 Helix-turn-helix domain; Region: HTH_20; pfam12840 710696000297 Predicted transcriptional regulator [Transcription]; Region: COG2345 710696000298 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 710696000299 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 710696000300 dimer interface [polypeptide binding]; other site 710696000301 putative functional site; other site 710696000302 putative MPT binding site; other site 710696000303 YCII-related domain; Region: YCII; cl00999 710696000304 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 710696000305 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 710696000306 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 710696000307 GTP binding site; other site 710696000308 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 710696000309 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 710696000310 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 710696000311 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 710696000312 Uncharacterized conserved protein [Function unknown]; Region: COG4850 710696000313 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 710696000314 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 710696000315 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 710696000316 putative DNA binding site [nucleotide binding]; other site 710696000317 catalytic residue [active] 710696000318 putative H2TH interface [polypeptide binding]; other site 710696000319 putative catalytic residues [active] 710696000320 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710696000321 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710696000322 pyridoxamine kinase; Validated; Region: PRK05756 710696000323 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 710696000324 dimer interface [polypeptide binding]; other site 710696000325 pyridoxal binding site [chemical binding]; other site 710696000326 ATP binding site [chemical binding]; other site 710696000327 AAA ATPase domain; Region: AAA_16; pfam13191 710696000328 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 710696000329 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 710696000330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696000331 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710696000332 DNA binding residues [nucleotide binding] 710696000333 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 710696000334 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710696000335 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710696000336 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 710696000337 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710696000338 carboxyltransferase (CT) interaction site; other site 710696000339 biotinylation site [posttranslational modification]; other site 710696000340 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 710696000341 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710696000342 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 710696000343 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696000344 putative DNA binding site [nucleotide binding]; other site 710696000345 putative Zn2+ binding site [ion binding]; other site 710696000346 AsnC family; Region: AsnC_trans_reg; pfam01037 710696000347 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 710696000348 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 710696000349 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710696000350 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710696000351 catalytic residue [active] 710696000352 tyrosine phenol-lyase; Provisional; Region: PRK13237 710696000353 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 710696000354 substrate binding site [chemical binding]; other site 710696000355 tetramer interface [polypeptide binding]; other site 710696000356 catalytic residue [active] 710696000357 AAA ATPase domain; Region: AAA_16; pfam13191 710696000358 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710696000359 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710696000360 DNA binding residues [nucleotide binding] 710696000361 dimerization interface [polypeptide binding]; other site 710696000362 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 710696000363 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710696000364 active site 710696000365 CoA binding site [chemical binding]; other site 710696000366 AMP binding site [chemical binding]; other site 710696000367 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 710696000368 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 710696000369 putative NAD(P) binding site [chemical binding]; other site 710696000370 putative active site [active] 710696000371 TspO/MBR family; Region: TspO_MBR; pfam03073 710696000372 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 710696000373 DNA photolyase; Region: DNA_photolyase; pfam00875 710696000374 short chain dehydrogenase; Provisional; Region: PRK07024 710696000375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696000376 NAD(P) binding site [chemical binding]; other site 710696000377 active site 710696000378 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 710696000379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696000380 S-adenosylmethionine binding site [chemical binding]; other site 710696000381 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 710696000382 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 710696000383 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710696000384 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 710696000385 putative hydrophobic ligand binding site [chemical binding]; other site 710696000386 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710696000387 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 710696000388 DNA binding residues [nucleotide binding] 710696000389 B12 binding domain; Region: B12-binding_2; pfam02607 710696000390 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 710696000391 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 710696000392 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 710696000393 NodB motif; other site 710696000394 active site 710696000395 catalytic site [active] 710696000396 metal binding site [ion binding]; metal-binding site 710696000397 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 710696000398 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 710696000399 Sulfate transporter family; Region: Sulfate_transp; pfam00916 710696000400 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 710696000401 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 710696000402 PEP synthetase regulatory protein; Provisional; Region: PRK05339 710696000403 phosphoenolpyruvate synthase; Validated; Region: PRK06464 710696000404 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 710696000405 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 710696000406 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 710696000407 DNA methylase; Region: N6_N4_Mtase; cl17433 710696000408 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710696000409 active site residue [active] 710696000410 SprT homologues; Region: SprT; cl01182 710696000411 SprT-like family; Region: SprT-like; pfam10263 710696000412 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 710696000413 active site 710696000414 SAM binding site [chemical binding]; other site 710696000415 homodimer interface [polypeptide binding]; other site 710696000416 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 710696000417 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710696000418 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 710696000419 Na2 binding site [ion binding]; other site 710696000420 putative substrate binding site 1 [chemical binding]; other site 710696000421 Na binding site 1 [ion binding]; other site 710696000422 putative substrate binding site 2 [chemical binding]; other site 710696000423 Predicted transcriptional regulators [Transcription]; Region: COG1695 710696000424 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696000425 putative Zn2+ binding site [ion binding]; other site 710696000426 putative DNA binding site [nucleotide binding]; other site 710696000427 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710696000428 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 710696000429 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710696000430 active site 710696000431 prephenate dehydratase; Provisional; Region: PRK11898 710696000432 Prephenate dehydratase; Region: PDT; pfam00800 710696000433 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 710696000434 putative L-Phe binding site [chemical binding]; other site 710696000435 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 710696000436 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710696000437 active site 710696000438 Iron permease FTR1 family; Region: FTR1; cl00475 710696000439 putative lipid kinase; Reviewed; Region: PRK13337 710696000440 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 710696000441 DinB superfamily; Region: DinB_2; pfam12867 710696000442 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710696000443 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710696000444 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 710696000445 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 710696000446 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 710696000447 DinB superfamily; Region: DinB_2; pfam12867 710696000448 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 710696000449 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 710696000450 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 710696000451 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 710696000452 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 710696000453 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 710696000454 Walker A/P-loop; other site 710696000455 ATP binding site [chemical binding]; other site 710696000456 Q-loop/lid; other site 710696000457 ABC transporter signature motif; other site 710696000458 Walker B; other site 710696000459 D-loop; other site 710696000460 H-loop/switch region; other site 710696000461 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 710696000462 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 710696000463 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710696000464 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 710696000465 Walker A/P-loop; other site 710696000466 ATP binding site [chemical binding]; other site 710696000467 Q-loop/lid; other site 710696000468 ABC transporter signature motif; other site 710696000469 Walker B; other site 710696000470 D-loop; other site 710696000471 H-loop/switch region; other site 710696000472 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 710696000473 seryl-tRNA synthetase; Provisional; Region: PRK05431 710696000474 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 710696000475 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 710696000476 dimer interface [polypeptide binding]; other site 710696000477 active site 710696000478 motif 1; other site 710696000479 motif 2; other site 710696000480 motif 3; other site 710696000481 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 710696000482 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710696000483 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710696000484 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 710696000485 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 710696000486 Metal-binding active site; metal-binding site 710696000487 FOG: WD40-like repeat [Function unknown]; Region: COG1520 710696000488 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 710696000489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710696000490 active site 710696000491 motif I; other site 710696000492 motif II; other site 710696000493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710696000494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 710696000495 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 710696000496 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710696000497 DNA binding residues [nucleotide binding] 710696000498 UreE urease accessory protein, C-terminal domain; Region: UreE_C; smart00987 710696000499 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710696000500 active site 710696000501 Isochorismatase family; Region: Isochorismatase; pfam00857 710696000502 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 710696000503 catalytic triad [active] 710696000504 conserved cis-peptide bond; other site 710696000505 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 710696000506 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 710696000507 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 710696000508 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 710696000509 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 710696000510 putative homodimer interface [polypeptide binding]; other site 710696000511 putative homotetramer interface [polypeptide binding]; other site 710696000512 putative allosteric switch controlling residues; other site 710696000513 putative metal binding site [ion binding]; other site 710696000514 putative homodimer-homodimer interface [polypeptide binding]; other site 710696000515 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 710696000516 metal-binding site [ion binding] 710696000517 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 710696000518 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 710696000519 metal-binding site [ion binding] 710696000520 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710696000521 adenylosuccinate lyase; Provisional; Region: PRK09285 710696000522 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 710696000523 tetramer interface [polypeptide binding]; other site 710696000524 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 710696000525 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710696000526 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 710696000527 Low molecular weight phosphatase family; Region: LMWPc; cd00115 710696000528 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 710696000529 active site 710696000530 enterobactin exporter EntS; Provisional; Region: PRK10489 710696000531 UDP-glucose 4-epimerase; Region: PLN02240 710696000532 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 710696000533 NAD binding site [chemical binding]; other site 710696000534 homodimer interface [polypeptide binding]; other site 710696000535 active site 710696000536 substrate binding site [chemical binding]; other site 710696000537 Peptidase family M48; Region: Peptidase_M48; cl12018 710696000538 Penicillinase repressor; Region: Pencillinase_R; pfam03965 710696000539 potential frameshift: common BLAST hit: gi|256824080|ref|YP_003148040.1| cysteine export CydDC family ABC transporter permease 710696000540 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 710696000541 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 710696000542 Walker A/P-loop; other site 710696000543 ATP binding site [chemical binding]; other site 710696000544 Q-loop/lid; other site 710696000545 ABC transporter signature motif; other site 710696000546 Walker B; other site 710696000547 D-loop; other site 710696000548 H-loop/switch region; other site 710696000549 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 710696000550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696000551 Walker A/P-loop; other site 710696000552 ATP binding site [chemical binding]; other site 710696000553 Q-loop/lid; other site 710696000554 ABC transporter signature motif; other site 710696000555 Walker B; other site 710696000556 D-loop; other site 710696000557 H-loop/switch region; other site 710696000558 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 710696000559 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 710696000560 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 710696000561 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 710696000562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710696000563 DNA-binding site [nucleotide binding]; DNA binding site 710696000564 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 710696000565 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 710696000566 quinone interaction residues [chemical binding]; other site 710696000567 active site 710696000568 catalytic residues [active] 710696000569 FMN binding site [chemical binding]; other site 710696000570 substrate binding site [chemical binding]; other site 710696000571 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710696000572 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 710696000573 acyl-activating enzyme (AAE) consensus motif; other site 710696000574 AMP binding site [chemical binding]; other site 710696000575 active site 710696000576 CoA binding site [chemical binding]; other site 710696000577 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 710696000578 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 710696000579 Walker A/P-loop; other site 710696000580 ATP binding site [chemical binding]; other site 710696000581 Q-loop/lid; other site 710696000582 ABC transporter signature motif; other site 710696000583 Walker B; other site 710696000584 D-loop; other site 710696000585 H-loop/switch region; other site 710696000586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696000587 dimer interface [polypeptide binding]; other site 710696000588 conserved gate region; other site 710696000589 putative PBP binding loops; other site 710696000590 ABC-ATPase subunit interface; other site 710696000591 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710696000592 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710696000593 substrate binding pocket [chemical binding]; other site 710696000594 membrane-bound complex binding site; other site 710696000595 hinge residues; other site 710696000596 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 710696000597 DEAD-like helicases superfamily; Region: DEXDc; smart00487 710696000598 ATP binding site [chemical binding]; other site 710696000599 putative Mg++ binding site [ion binding]; other site 710696000600 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710696000601 nucleotide binding region [chemical binding]; other site 710696000602 ATP-binding site [chemical binding]; other site 710696000603 RDD family; Region: RDD; pfam06271 710696000604 Integral membrane protein DUF95; Region: DUF95; pfam01944 710696000605 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 710696000606 Protein of unknown function DUF58; Region: DUF58; pfam01882 710696000607 MoxR-like ATPases [General function prediction only]; Region: COG0714 710696000608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 710696000609 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 710696000610 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 710696000611 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710696000612 CoenzymeA binding site [chemical binding]; other site 710696000613 subunit interaction site [polypeptide binding]; other site 710696000614 PHB binding site; other site 710696000615 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 710696000616 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 710696000617 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 710696000618 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 710696000619 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 710696000620 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710696000621 NAD(P) binding site [chemical binding]; other site 710696000622 catalytic residues [active] 710696000623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696000624 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 710696000625 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 710696000626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696000627 Walker A/P-loop; other site 710696000628 ATP binding site [chemical binding]; other site 710696000629 Q-loop/lid; other site 710696000630 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 710696000631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696000632 ABC transporter signature motif; other site 710696000633 Walker B; other site 710696000634 D-loop; other site 710696000635 H-loop/switch region; other site 710696000636 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 710696000637 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 710696000638 active site 710696000639 metal binding site [ion binding]; metal-binding site 710696000640 DNA binding site [nucleotide binding] 710696000641 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 710696000642 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 710696000643 TfoX N-terminal domain; Region: TfoX_N; cl17592 710696000644 Membrane protein of unknown function; Region: DUF360; pfam04020 710696000645 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 710696000646 phosphofructokinase; Region: PFK_mixed; TIGR02483 710696000647 active site 710696000648 ADP/pyrophosphate binding site [chemical binding]; other site 710696000649 dimerization interface [polypeptide binding]; other site 710696000650 allosteric effector site; other site 710696000651 fructose-1,6-bisphosphate binding site; other site 710696000652 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 710696000653 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710696000654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696000655 homodimer interface [polypeptide binding]; other site 710696000656 catalytic residue [active] 710696000657 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 710696000658 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 710696000659 TPP-binding site [chemical binding]; other site 710696000660 heterodimer interface [polypeptide binding]; other site 710696000661 tetramer interface [polypeptide binding]; other site 710696000662 phosphorylation loop region [posttranslational modification] 710696000663 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 710696000664 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 710696000665 alpha subunit interface [polypeptide binding]; other site 710696000666 TPP binding site [chemical binding]; other site 710696000667 heterodimer interface [polypeptide binding]; other site 710696000668 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710696000669 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710696000670 E3 interaction surface; other site 710696000671 lipoyl attachment site [posttranslational modification]; other site 710696000672 e3 binding domain; Region: E3_binding; pfam02817 710696000673 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 710696000674 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 710696000675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696000676 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710696000677 putative substrate translocation pore; other site 710696000678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696000679 putative substrate translocation pore; other site 710696000680 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710696000681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696000682 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 710696000683 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 710696000684 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 710696000685 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710696000686 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710696000687 active site 710696000688 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710696000689 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710696000690 enoyl-CoA hydratase; Provisional; Region: PRK05870 710696000691 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710696000692 substrate binding site [chemical binding]; other site 710696000693 oxyanion hole (OAH) forming residues; other site 710696000694 trimer interface [polypeptide binding]; other site 710696000695 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710696000696 GAF domain; Region: GAF_2; pfam13185 710696000697 GAF domain; Region: GAF; pfam01590 710696000698 ANTAR domain; Region: ANTAR; pfam03861 710696000699 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710696000700 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710696000701 Copper resistance protein D; Region: CopD; pfam05425 710696000702 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 710696000703 Predicted amidohydrolase [General function prediction only]; Region: COG0388 710696000704 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 710696000705 putative active site [active] 710696000706 catalytic triad [active] 710696000707 putative dimer interface [polypeptide binding]; other site 710696000708 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710696000709 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710696000710 Acyltransferase family; Region: Acyl_transf_3; pfam01757 710696000711 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 710696000712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696000713 Coenzyme A binding pocket [chemical binding]; other site 710696000714 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 710696000715 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 710696000716 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710696000717 active site 710696000718 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 710696000719 Predicted esterase [General function prediction only]; Region: COG0400 710696000720 putative hydrolase; Provisional; Region: PRK11460 710696000721 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 710696000722 MarR family; Region: MarR_2; pfam12802 710696000723 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 710696000724 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 710696000725 amidase catalytic site [active] 710696000726 Zn binding residues [ion binding]; other site 710696000727 substrate binding site [chemical binding]; other site 710696000728 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 710696000729 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 710696000730 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 710696000731 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 710696000732 active site 710696000733 NTP binding site [chemical binding]; other site 710696000734 metal binding triad [ion binding]; metal-binding site 710696000735 Protein of unknown function DUF86; Region: DUF86; cl01031 710696000736 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 710696000737 trimer interface [polypeptide binding]; other site 710696000738 active site 710696000739 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 710696000740 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 710696000741 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 710696000742 Walker A/P-loop; other site 710696000743 ATP binding site [chemical binding]; other site 710696000744 Q-loop/lid; other site 710696000745 ABC transporter signature motif; other site 710696000746 Walker B; other site 710696000747 D-loop; other site 710696000748 H-loop/switch region; other site 710696000749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 710696000750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 710696000751 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 710696000752 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710696000753 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710696000754 Cytochrome P450; Region: p450; cl12078 710696000755 FOG: WD40 repeat [General function prediction only]; Region: COG2319 710696000756 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 710696000757 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 710696000758 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 710696000759 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710696000760 NAD(P) binding site [chemical binding]; other site 710696000761 catalytic residues [active] 710696000762 Protein of unknown function (DUF779); Region: DUF779; pfam05610 710696000763 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 710696000764 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 710696000765 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 710696000766 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 710696000767 Binuclear center (active site) [active] 710696000768 K-pathway; other site 710696000769 Putative proton exit pathway; other site 710696000770 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 710696000771 4Fe-4S binding domain; Region: Fer4; cl02805 710696000772 Cysteine-rich domain; Region: CCG; pfam02754 710696000773 Cysteine-rich domain; Region: CCG; pfam02754 710696000774 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 710696000775 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 710696000776 dimer interface [polypeptide binding]; other site 710696000777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696000778 catalytic residue [active] 710696000779 serine O-acetyltransferase; Region: cysE; TIGR01172 710696000780 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 710696000781 trimer interface [polypeptide binding]; other site 710696000782 active site 710696000783 substrate binding site [chemical binding]; other site 710696000784 CoA binding site [chemical binding]; other site 710696000785 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 710696000786 dihydropteroate synthase; Region: DHPS; TIGR01496 710696000787 substrate binding pocket [chemical binding]; other site 710696000788 dimer interface [polypeptide binding]; other site 710696000789 inhibitor binding site; inhibition site 710696000790 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 710696000791 DNA-binding site [nucleotide binding]; DNA binding site 710696000792 RNA-binding motif; other site 710696000793 Transcriptional regulator [Transcription]; Region: LytR; COG1316 710696000794 Transcriptional regulator [Transcription]; Region: LytR; COG1316 710696000795 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 710696000796 active site 710696000797 substrate-binding site [chemical binding]; other site 710696000798 metal-binding site [ion binding] 710696000799 GTP binding site [chemical binding]; other site 710696000800 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710696000801 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710696000802 active site 710696000803 DNA binding site [nucleotide binding] 710696000804 Int/Topo IB signature motif; other site 710696000805 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 710696000806 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710696000807 active site 710696000808 DNA binding site [nucleotide binding] 710696000809 Int/Topo IB signature motif; other site 710696000810 AAA domain; Region: AAA_14; pfam13173 710696000811 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 710696000812 Uncharacterized conserved protein [Function unknown]; Region: COG3422 710696000813 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 710696000814 Transposase; Region: DDE_Tnp_ISL3; pfam01610 710696000815 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710696000816 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 710696000817 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 710696000818 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 710696000819 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 710696000820 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 710696000821 Trp docking motif [polypeptide binding]; other site 710696000822 active site 710696000823 PQQ-like domain; Region: PQQ_2; pfam13360 710696000824 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 710696000825 ligand binding surface [chemical binding]; other site 710696000826 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 710696000827 Strictosidine synthase; Region: Str_synth; pfam03088 710696000828 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 710696000829 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 710696000830 active site 710696000831 NTP binding site [chemical binding]; other site 710696000832 metal binding triad [ion binding]; metal-binding site 710696000833 HEPN domain; Region: HEPN; pfam05168 710696000834 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 710696000835 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 710696000836 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 710696000837 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 710696000838 NAD binding site [chemical binding]; other site 710696000839 substrate binding site [chemical binding]; other site 710696000840 catalytic Zn binding site [ion binding]; other site 710696000841 structural Zn binding site [ion binding]; other site 710696000842 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 710696000843 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 710696000844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696000845 dimer interface [polypeptide binding]; other site 710696000846 ABC-ATPase subunit interface; other site 710696000847 putative PBP binding loops; other site 710696000848 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710696000849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696000850 dimer interface [polypeptide binding]; other site 710696000851 conserved gate region; other site 710696000852 putative PBP binding loops; other site 710696000853 ABC-ATPase subunit interface; other site 710696000854 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 710696000855 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 710696000856 Walker A/P-loop; other site 710696000857 ATP binding site [chemical binding]; other site 710696000858 Q-loop/lid; other site 710696000859 ABC transporter signature motif; other site 710696000860 Walker B; other site 710696000861 D-loop; other site 710696000862 H-loop/switch region; other site 710696000863 TOBE domain; Region: TOBE_2; pfam08402 710696000864 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 710696000865 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 710696000866 Walker A/P-loop; other site 710696000867 ATP binding site [chemical binding]; other site 710696000868 Q-loop/lid; other site 710696000869 ABC transporter signature motif; other site 710696000870 Walker B; other site 710696000871 D-loop; other site 710696000872 H-loop/switch region; other site 710696000873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696000874 S-adenosylmethionine binding site [chemical binding]; other site 710696000875 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 710696000876 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 710696000877 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 710696000878 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 710696000879 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 710696000880 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 710696000881 Fic/DOC family; Region: Fic; cl00960 710696000882 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 710696000883 UTRA domain; Region: UTRA; pfam07702 710696000884 AMP-binding domain protein; Validated; Region: PRK08315 710696000885 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710696000886 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 710696000887 acyl-activating enzyme (AAE) consensus motif; other site 710696000888 putative AMP binding site [chemical binding]; other site 710696000889 putative active site [active] 710696000890 putative CoA binding site [chemical binding]; other site 710696000891 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 710696000892 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710696000893 acyl-activating enzyme (AAE) consensus motif; other site 710696000894 AMP binding site [chemical binding]; other site 710696000895 active site 710696000896 CoA binding site [chemical binding]; other site 710696000897 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 710696000898 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 710696000899 Walker A/P-loop; other site 710696000900 ATP binding site [chemical binding]; other site 710696000901 Q-loop/lid; other site 710696000902 ABC transporter signature motif; other site 710696000903 Walker B; other site 710696000904 D-loop; other site 710696000905 H-loop/switch region; other site 710696000906 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 710696000907 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 710696000908 putative ligand binding site [chemical binding]; other site 710696000909 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 710696000910 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 710696000911 TM-ABC transporter signature motif; other site 710696000912 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 710696000913 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710696000914 TM-ABC transporter signature motif; other site 710696000915 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 710696000916 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710696000917 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 710696000918 acyl-activating enzyme (AAE) consensus motif; other site 710696000919 putative AMP binding site [chemical binding]; other site 710696000920 putative active site [active] 710696000921 putative CoA binding site [chemical binding]; other site 710696000922 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 710696000923 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 710696000924 Walker A/P-loop; other site 710696000925 ATP binding site [chemical binding]; other site 710696000926 Q-loop/lid; other site 710696000927 ABC transporter signature motif; other site 710696000928 Walker B; other site 710696000929 D-loop; other site 710696000930 H-loop/switch region; other site 710696000931 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710696000932 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696000933 putative DNA binding site [nucleotide binding]; other site 710696000934 putative Zn2+ binding site [ion binding]; other site 710696000935 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710696000936 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 710696000937 acyl-activating enzyme (AAE) consensus motif; other site 710696000938 AMP binding site [chemical binding]; other site 710696000939 active site 710696000940 CoA binding site [chemical binding]; other site 710696000941 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 710696000942 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 710696000943 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 710696000944 arginine-tRNA ligase; Region: PLN02286 710696000945 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 710696000946 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710696000947 active site 710696000948 HIGH motif; other site 710696000949 nucleotide binding site [chemical binding]; other site 710696000950 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 710696000951 KMSK motif region; other site 710696000952 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 710696000953 tRNA binding surface [nucleotide binding]; other site 710696000954 anticodon binding site; other site 710696000955 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710696000956 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710696000957 DNA binding site [nucleotide binding] 710696000958 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710696000959 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 710696000960 OsmC-like protein; Region: OsmC; pfam02566 710696000961 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710696000962 catalytic residues [active] 710696000963 Domain of unknown function DUF302; Region: DUF302; pfam03625 710696000964 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710696000965 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710696000966 active site 710696000967 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 710696000968 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710696000969 substrate binding site [chemical binding]; other site 710696000970 oxyanion hole (OAH) forming residues; other site 710696000971 trimer interface [polypeptide binding]; other site 710696000972 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 710696000973 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710696000974 dimer interface [polypeptide binding]; other site 710696000975 active site 710696000976 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 710696000977 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 710696000978 acyl-activating enzyme (AAE) consensus motif; other site 710696000979 putative AMP binding site [chemical binding]; other site 710696000980 putative active site [active] 710696000981 putative CoA binding site [chemical binding]; other site 710696000982 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710696000983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696000984 NAD(P) binding site [chemical binding]; other site 710696000985 active site 710696000986 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 710696000987 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710696000988 active site 710696000989 enoyl-CoA hydratase; Provisional; Region: PRK06688 710696000990 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710696000991 substrate binding site [chemical binding]; other site 710696000992 oxyanion hole (OAH) forming residues; other site 710696000993 trimer interface [polypeptide binding]; other site 710696000994 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710696000995 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696000996 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 710696000997 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 710696000998 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 710696000999 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 710696001000 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 710696001001 [4Fe-4S] binding site [ion binding]; other site 710696001002 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710696001003 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710696001004 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710696001005 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 710696001006 molybdopterin cofactor binding site; other site 710696001007 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696001008 putative DNA binding site [nucleotide binding]; other site 710696001009 dimerization interface [polypeptide binding]; other site 710696001010 Predicted transcriptional regulator [Transcription]; Region: COG2345 710696001011 putative Zn2+ binding site [ion binding]; other site 710696001012 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 710696001013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696001014 putative substrate translocation pore; other site 710696001015 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 710696001016 enoyl-CoA hydratase; Provisional; Region: PRK07509 710696001017 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710696001018 substrate binding site [chemical binding]; other site 710696001019 oxyanion hole (OAH) forming residues; other site 710696001020 trimer interface [polypeptide binding]; other site 710696001021 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 710696001022 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 710696001023 ligand binding site [chemical binding]; other site 710696001024 homodimer interface [polypeptide binding]; other site 710696001025 NAD(P) binding site [chemical binding]; other site 710696001026 trimer interface B [polypeptide binding]; other site 710696001027 trimer interface A [polypeptide binding]; other site 710696001028 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 710696001029 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 710696001030 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 710696001031 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710696001032 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710696001033 salt bridge; other site 710696001034 sequence-specific DNA binding site [nucleotide binding]; other site 710696001035 Bacterial PH domain; Region: DUF304; pfam03703 710696001036 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 710696001037 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710696001038 active site 710696001039 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 710696001040 nucleoside/Zn binding site; other site 710696001041 dimer interface [polypeptide binding]; other site 710696001042 catalytic motif [active] 710696001043 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 710696001044 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 710696001045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696001046 S-adenosylmethionine binding site [chemical binding]; other site 710696001047 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710696001048 hydroxyglutarate oxidase; Provisional; Region: PRK11728 710696001049 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 710696001050 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 710696001051 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710696001052 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710696001053 DNA binding residues [nucleotide binding] 710696001054 dimerization interface [polypeptide binding]; other site 710696001055 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710696001056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696001057 S-adenosylmethionine binding site [chemical binding]; other site 710696001058 Peptidase family M23; Region: Peptidase_M23; pfam01551 710696001059 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710696001060 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710696001061 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 710696001062 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 710696001063 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 710696001064 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710696001065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696001066 dimer interface [polypeptide binding]; other site 710696001067 conserved gate region; other site 710696001068 putative PBP binding loops; other site 710696001069 ABC-ATPase subunit interface; other site 710696001070 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 710696001071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696001072 conserved gate region; other site 710696001073 dimer interface [polypeptide binding]; other site 710696001074 putative PBP binding loops; other site 710696001075 ABC-ATPase subunit interface; other site 710696001076 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 710696001077 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 710696001078 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 710696001079 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710696001080 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 710696001081 substrate binding site [chemical binding]; other site 710696001082 ATP binding site [chemical binding]; other site 710696001083 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 710696001084 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 710696001085 NAD binding site [chemical binding]; other site 710696001086 sugar binding site [chemical binding]; other site 710696001087 divalent metal binding site [ion binding]; other site 710696001088 tetramer (dimer of dimers) interface [polypeptide binding]; other site 710696001089 dimer interface [polypeptide binding]; other site 710696001090 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 710696001091 catalytic site [active] 710696001092 BNR repeat-like domain; Region: BNR_2; pfam13088 710696001093 Asp-box motif; other site 710696001094 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 710696001095 Laminin G domain; Region: Laminin_G_2; pfam02210 710696001096 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 710696001097 sugar binding site [chemical binding]; other site 710696001098 ornithine carbamoyltransferase; Validated; Region: PRK02102 710696001099 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 710696001100 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 710696001101 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710696001102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696001103 hypothetical protein; Provisional; Region: PRK01346 710696001104 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 710696001105 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 710696001106 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710696001107 ATP binding site [chemical binding]; other site 710696001108 putative Mg++ binding site [ion binding]; other site 710696001109 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710696001110 nucleotide binding region [chemical binding]; other site 710696001111 ATP-binding site [chemical binding]; other site 710696001112 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696001113 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 710696001114 Walker A/P-loop; other site 710696001115 ATP binding site [chemical binding]; other site 710696001116 Q-loop/lid; other site 710696001117 ABC transporter signature motif; other site 710696001118 Walker B; other site 710696001119 D-loop; other site 710696001120 H-loop/switch region; other site 710696001121 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 710696001122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696001123 Walker A motif; other site 710696001124 ATP binding site [chemical binding]; other site 710696001125 Walker B motif; other site 710696001126 arginine finger; other site 710696001127 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 710696001128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696001129 S-adenosylmethionine binding site [chemical binding]; other site 710696001130 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710696001131 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710696001132 putative acyl-acceptor binding pocket; other site 710696001133 recombination protein RecR; Reviewed; Region: recR; PRK00076 710696001134 RecR protein; Region: RecR; pfam02132 710696001135 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 710696001136 putative active site [active] 710696001137 putative metal-binding site [ion binding]; other site 710696001138 tetramer interface [polypeptide binding]; other site 710696001139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710696001140 non-specific DNA binding site [nucleotide binding]; other site 710696001141 salt bridge; other site 710696001142 sequence-specific DNA binding site [nucleotide binding]; other site 710696001143 aspartate kinase; Reviewed; Region: PRK06635 710696001144 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 710696001145 putative nucleotide binding site [chemical binding]; other site 710696001146 putative catalytic residues [active] 710696001147 putative Mg ion binding site [ion binding]; other site 710696001148 putative aspartate binding site [chemical binding]; other site 710696001149 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 710696001150 putative allosteric regulatory site; other site 710696001151 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 710696001152 putative allosteric regulatory residue; other site 710696001153 PAS fold; Region: PAS_4; pfam08448 710696001154 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710696001155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710696001156 dimer interface [polypeptide binding]; other site 710696001157 phosphorylation site [posttranslational modification] 710696001158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696001159 ATP binding site [chemical binding]; other site 710696001160 Mg2+ binding site [ion binding]; other site 710696001161 G-X-G motif; other site 710696001162 Response regulator receiver domain; Region: Response_reg; pfam00072 710696001163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696001164 active site 710696001165 phosphorylation site [posttranslational modification] 710696001166 intermolecular recognition site; other site 710696001167 dimerization interface [polypeptide binding]; other site 710696001168 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710696001169 PAS domain; Region: PAS_9; pfam13426 710696001170 putative active site [active] 710696001171 heme pocket [chemical binding]; other site 710696001172 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710696001173 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 710696001174 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 710696001175 active site 710696001176 DNA binding site [nucleotide binding] 710696001177 Int/Topo IB signature motif; other site 710696001178 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 710696001179 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710696001180 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710696001181 hydrophobic ligand binding site; other site 710696001182 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 710696001183 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 710696001184 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 710696001185 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 710696001186 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710696001187 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710696001188 iron-sulfur cluster [ion binding]; other site 710696001189 [2Fe-2S] cluster binding site [ion binding]; other site 710696001190 trehalose synthase; Region: treS_nterm; TIGR02456 710696001191 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 710696001192 active site 710696001193 catalytic site [active] 710696001194 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 710696001195 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 710696001196 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 710696001197 trimer interface [polypeptide binding]; other site 710696001198 active site 710696001199 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 710696001200 catalytic site [active] 710696001201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696001202 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710696001203 Walker A/P-loop; other site 710696001204 ATP binding site [chemical binding]; other site 710696001205 Q-loop/lid; other site 710696001206 ABC transporter signature motif; other site 710696001207 Walker B; other site 710696001208 D-loop; other site 710696001209 H-loop/switch region; other site 710696001210 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710696001211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696001212 Walker A/P-loop; other site 710696001213 ATP binding site [chemical binding]; other site 710696001214 Q-loop/lid; other site 710696001215 ABC transporter signature motif; other site 710696001216 Walker B; other site 710696001217 D-loop; other site 710696001218 H-loop/switch region; other site 710696001219 trehalose synthase; Region: treS_nterm; TIGR02456 710696001220 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 710696001221 active site 710696001222 catalytic site [active] 710696001223 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 710696001224 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710696001225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696001226 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710696001227 NAD(P) binding site [chemical binding]; other site 710696001228 active site 710696001229 carboxylate-amine ligase; Provisional; Region: PRK13517 710696001230 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 710696001231 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 710696001232 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696001233 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 710696001234 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710696001235 DNA binding residues [nucleotide binding] 710696001236 Helix-turn-helix domain; Region: HTH_18; pfam12833 710696001237 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 710696001238 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 710696001239 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 710696001240 Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104 710696001241 putative active site [active] 710696001242 catalytic site [active] 710696001243 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 710696001244 putative active site [active] 710696001245 catalytic site [active] 710696001246 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 710696001247 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 710696001248 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 710696001249 putative active site [active] 710696001250 putative metal binding site [ion binding]; other site 710696001251 Yqey-like protein; Region: YqeY; pfam09424 710696001252 Transglycosylase; Region: Transgly; pfam00912 710696001253 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 710696001254 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 710696001255 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 710696001256 Transcription factor WhiB; Region: Whib; pfam02467 710696001257 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 710696001258 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 710696001259 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 710696001260 DTAP/Switch II; other site 710696001261 putative hydrolase; Provisional; Region: PRK11460 710696001262 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 710696001263 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 710696001264 homotrimer interaction site [polypeptide binding]; other site 710696001265 putative active site [active] 710696001266 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710696001267 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710696001268 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710696001269 ligand binding site [chemical binding]; other site 710696001270 flexible hinge region; other site 710696001271 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 710696001272 putative switch regulator; other site 710696001273 non-specific DNA interactions [nucleotide binding]; other site 710696001274 DNA binding site [nucleotide binding] 710696001275 sequence specific DNA binding site [nucleotide binding]; other site 710696001276 putative cAMP binding site [chemical binding]; other site 710696001277 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 710696001278 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 710696001279 minor groove reading motif; other site 710696001280 helix-hairpin-helix signature motif; other site 710696001281 substrate binding pocket [chemical binding]; other site 710696001282 active site 710696001283 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 710696001284 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 710696001285 putative active site [active] 710696001286 putative CoA binding site [chemical binding]; other site 710696001287 nudix motif; other site 710696001288 metal binding site [ion binding]; metal-binding site 710696001289 Colicin V production protein; Region: Colicin_V; pfam02674 710696001290 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 710696001291 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710696001292 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710696001293 Ligand Binding Site [chemical binding]; other site 710696001294 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 710696001295 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 710696001296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 710696001297 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 710696001298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696001299 ATP binding site [chemical binding]; other site 710696001300 Mg2+ binding site [ion binding]; other site 710696001301 G-X-G motif; other site 710696001302 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 710696001303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696001304 active site 710696001305 phosphorylation site [posttranslational modification] 710696001306 intermolecular recognition site; other site 710696001307 dimerization interface [polypeptide binding]; other site 710696001308 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 710696001309 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 710696001310 active site 710696001311 catalytic residues [active] 710696001312 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 710696001313 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710696001314 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710696001315 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 710696001316 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 710696001317 substrate binding site [chemical binding]; other site 710696001318 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 710696001319 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 710696001320 putative trimer interface [polypeptide binding]; other site 710696001321 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 710696001322 trimer interface [polypeptide binding]; other site 710696001323 active site 710696001324 substrate binding site [chemical binding]; other site 710696001325 putative CoA binding site [chemical binding]; other site 710696001326 CoA binding site [chemical binding]; other site 710696001327 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 710696001328 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 710696001329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696001330 inhibitor-cofactor binding pocket; inhibition site 710696001331 catalytic residue [active] 710696001332 GtrA-like protein; Region: GtrA; pfam04138 710696001333 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 710696001334 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710696001335 active site 710696001336 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 710696001337 Flp/Fap pilin component; Region: Flp_Fap; cl01585 710696001338 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 710696001339 AAA domain; Region: AAA_31; pfam13614 710696001340 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710696001341 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 710696001342 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 710696001343 ATP binding site [chemical binding]; other site 710696001344 Walker A motif; other site 710696001345 hexamer interface [polypeptide binding]; other site 710696001346 Walker B motif; other site 710696001347 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 710696001348 metal ion-dependent adhesion site (MIDAS); other site 710696001349 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 710696001350 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 710696001351 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 710696001352 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 710696001353 Cupin superfamily protein; Region: Cupin_4; pfam08007 710696001354 Cupin-like domain; Region: Cupin_8; pfam13621 710696001355 Predicted flavoprotein [General function prediction only]; Region: COG0431 710696001356 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710696001357 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 710696001358 Domain of unknown function DUF21; Region: DUF21; pfam01595 710696001359 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 710696001360 Transporter associated domain; Region: CorC_HlyC; smart01091 710696001361 META domain; Region: META; pfam03724 710696001362 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710696001363 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710696001364 active site 710696001365 acetyl-CoA synthetase; Provisional; Region: PRK00174 710696001366 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 710696001367 active site 710696001368 CoA binding site [chemical binding]; other site 710696001369 acyl-activating enzyme (AAE) consensus motif; other site 710696001370 AMP binding site [chemical binding]; other site 710696001371 acetate binding site [chemical binding]; other site 710696001372 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 710696001373 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710696001374 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 710696001375 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 710696001376 ATP binding site [chemical binding]; other site 710696001377 Walker A motif; other site 710696001378 hexamer interface [polypeptide binding]; other site 710696001379 Walker B motif; other site 710696001380 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 710696001381 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 710696001382 Predicted transcriptional regulator [Transcription]; Region: COG1959 710696001383 Transcriptional regulator; Region: Rrf2; pfam02082 710696001384 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 710696001385 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 710696001386 Walker A/P-loop; other site 710696001387 ATP binding site [chemical binding]; other site 710696001388 Q-loop/lid; other site 710696001389 ABC transporter signature motif; other site 710696001390 Walker B; other site 710696001391 D-loop; other site 710696001392 H-loop/switch region; other site 710696001393 sulfate transport protein; Provisional; Region: cysT; CHL00187 710696001394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696001395 dimer interface [polypeptide binding]; other site 710696001396 conserved gate region; other site 710696001397 putative PBP binding loops; other site 710696001398 ABC-ATPase subunit interface; other site 710696001399 sulfate transport protein; Provisional; Region: cysT; CHL00187 710696001400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696001401 dimer interface [polypeptide binding]; other site 710696001402 conserved gate region; other site 710696001403 putative PBP binding loops; other site 710696001404 ABC-ATPase subunit interface; other site 710696001405 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710696001406 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 710696001407 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 710696001408 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710696001409 active site 710696001410 catalytic residues [active] 710696001411 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 710696001412 PA/protease or protease-like domain interface [polypeptide binding]; other site 710696001413 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 710696001414 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 710696001415 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710696001416 ATP binding site [chemical binding]; other site 710696001417 putative Mg++ binding site [ion binding]; other site 710696001418 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710696001419 nucleotide binding region [chemical binding]; other site 710696001420 ATP-binding site [chemical binding]; other site 710696001421 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710696001422 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 710696001423 anti sigma factor interaction site; other site 710696001424 regulatory phosphorylation site [posttranslational modification]; other site 710696001425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710696001426 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 710696001427 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710696001428 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696001429 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710696001430 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710696001431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696001432 Walker A/P-loop; other site 710696001433 ATP binding site [chemical binding]; other site 710696001434 Q-loop/lid; other site 710696001435 ABC transporter signature motif; other site 710696001436 Walker B; other site 710696001437 D-loop; other site 710696001438 H-loop/switch region; other site 710696001439 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710696001440 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710696001441 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 710696001442 Walker A/P-loop; other site 710696001443 ATP binding site [chemical binding]; other site 710696001444 Q-loop/lid; other site 710696001445 ABC transporter signature motif; other site 710696001446 Walker B; other site 710696001447 D-loop; other site 710696001448 H-loop/switch region; other site 710696001449 glycyl-tRNA synthetase; Provisional; Region: PRK14908 710696001450 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 710696001451 dimer interface [polypeptide binding]; other site 710696001452 motif 1; other site 710696001453 active site 710696001454 motif 2; other site 710696001455 motif 3; other site 710696001456 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 710696001457 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 710696001458 oligomer interface [polypeptide binding]; other site 710696001459 metal binding site [ion binding]; metal-binding site 710696001460 metal binding site [ion binding]; metal-binding site 710696001461 putative Cl binding site [ion binding]; other site 710696001462 hydrophobic gate; other site 710696001463 periplasmic entrance; other site 710696001464 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 710696001465 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 710696001466 DNA binding residues [nucleotide binding] 710696001467 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 710696001468 AAA domain; Region: AAA_18; pfam13238 710696001469 active site 710696001470 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 710696001471 Double zinc ribbon; Region: DZR; pfam12773 710696001472 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710696001473 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710696001474 phosphopeptide binding site; other site 710696001475 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 710696001476 metal ion-dependent adhesion site (MIDAS); other site 710696001477 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 710696001478 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 710696001479 active site 710696001480 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710696001481 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710696001482 active site 710696001483 ATP binding site [chemical binding]; other site 710696001484 substrate binding site [chemical binding]; other site 710696001485 activation loop (A-loop); other site 710696001486 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710696001487 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710696001488 substrate binding pocket [chemical binding]; other site 710696001489 membrane-bound complex binding site; other site 710696001490 hinge residues; other site 710696001491 stage V sporulation protein K; Region: spore_V_K; TIGR02881 710696001492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696001493 Walker A motif; other site 710696001494 ATP binding site [chemical binding]; other site 710696001495 Walker B motif; other site 710696001496 arginine finger; other site 710696001497 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 710696001498 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 710696001499 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 710696001500 putative active site [active] 710696001501 metal binding site [ion binding]; metal-binding site 710696001502 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 710696001503 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 710696001504 active site 710696001505 interdomain interaction site; other site 710696001506 putative metal-binding site [ion binding]; other site 710696001507 nucleotide binding site [chemical binding]; other site 710696001508 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 710696001509 domain I; other site 710696001510 phosphate binding site [ion binding]; other site 710696001511 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 710696001512 domain II; other site 710696001513 domain III; other site 710696001514 nucleotide binding site [chemical binding]; other site 710696001515 DNA binding groove [nucleotide binding] 710696001516 catalytic site [active] 710696001517 domain IV; other site 710696001518 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 710696001519 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 710696001520 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 710696001521 SCP-2 sterol transfer family; Region: SCP2; pfam02036 710696001522 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 710696001523 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 710696001524 Beta-lactamase; Region: Beta-lactamase; pfam00144 710696001525 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710696001526 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710696001527 DNA binding residues [nucleotide binding] 710696001528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 710696001529 Transposase; Region: DDE_Tnp_ISL3; pfam01610 710696001530 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 710696001531 Amidinotransferase; Region: Amidinotransf; cl12043 710696001532 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710696001533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710696001534 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 710696001535 dimerization interface [polypeptide binding]; other site 710696001536 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 710696001537 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 710696001538 active site 710696001539 Zn binding site [ion binding]; other site 710696001540 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 710696001541 Peptidase family M28; Region: Peptidase_M28; pfam04389 710696001542 active site 710696001543 metal binding site [ion binding]; metal-binding site 710696001544 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710696001545 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696001546 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 710696001547 DNA binding residues [nucleotide binding] 710696001548 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 710696001549 active site 710696001550 putative catalytic site [active] 710696001551 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 710696001552 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 710696001553 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 710696001554 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710696001555 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 710696001556 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 710696001557 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 710696001558 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 710696001559 DNA polymerase III subunit delta'; Validated; Region: PRK07940 710696001560 DNA polymerase III subunit delta'; Validated; Region: PRK08485 710696001561 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 710696001562 thymidylate kinase; Validated; Region: tmk; PRK00698 710696001563 TMP-binding site; other site 710696001564 ATP-binding site [chemical binding]; other site 710696001565 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 710696001566 TAP-like protein; Region: Abhydrolase_4; pfam08386 710696001567 TAP-like protein; Region: Abhydrolase_4; pfam08386 710696001568 TAP-like protein; Region: Abhydrolase_4; pfam08386 710696001569 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 710696001570 putative hydrophobic ligand binding site [chemical binding]; other site 710696001571 CLM binding site; other site 710696001572 L1 loop; other site 710696001573 DNA binding site [nucleotide binding] 710696001574 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696001575 putative DNA binding site [nucleotide binding]; other site 710696001576 putative Zn2+ binding site [ion binding]; other site 710696001577 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 710696001578 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 710696001579 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 710696001580 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 710696001581 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 710696001582 TrkA-N domain; Region: TrkA_N; pfam02254 710696001583 TrkA-C domain; Region: TrkA_C; pfam02080 710696001584 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 710696001585 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 710696001586 dimer interface [polypeptide binding]; other site 710696001587 active site 710696001588 heme binding site [chemical binding]; other site 710696001589 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 710696001590 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710696001591 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710696001592 substrate binding site [chemical binding]; other site 710696001593 oxyanion hole (OAH) forming residues; other site 710696001594 trimer interface [polypeptide binding]; other site 710696001595 acyl-CoA synthetase; Validated; Region: PRK08316 710696001596 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710696001597 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710696001598 acyl-activating enzyme (AAE) consensus motif; other site 710696001599 acyl-activating enzyme (AAE) consensus motif; other site 710696001600 putative AMP binding site [chemical binding]; other site 710696001601 putative active site [active] 710696001602 putative CoA binding site [chemical binding]; other site 710696001603 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 710696001604 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710696001605 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 710696001606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710696001607 motif II; other site 710696001608 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 710696001609 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 710696001610 Malic enzyme, N-terminal domain; Region: malic; pfam00390 710696001611 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 710696001612 putative NAD(P) binding site [chemical binding]; other site 710696001613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696001614 putative substrate translocation pore; other site 710696001615 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710696001616 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710696001617 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710696001618 Pirin-related protein [General function prediction only]; Region: COG1741 710696001619 Pirin; Region: Pirin; pfam02678 710696001620 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 710696001621 Predicted acetyltransferase [General function prediction only]; Region: COG2388 710696001622 Domain of unknown function (DUF202); Region: DUF202; cl09954 710696001623 Domain of unknown function (DUF202); Region: DUF202; cl09954 710696001624 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 710696001625 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 710696001626 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 710696001627 dimer interface [polypeptide binding]; other site 710696001628 substrate binding site [chemical binding]; other site 710696001629 metal binding sites [ion binding]; metal-binding site 710696001630 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 710696001631 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 710696001632 SnoaL-like domain; Region: SnoaL_2; pfam12680 710696001633 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 710696001634 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 710696001635 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 710696001636 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 710696001637 Ligand Binding Site [chemical binding]; other site 710696001638 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710696001639 active site 710696001640 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 710696001641 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 710696001642 FtsH Extracellular; Region: FtsH_ext; pfam06480 710696001643 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 710696001644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696001645 Walker A motif; other site 710696001646 ATP binding site [chemical binding]; other site 710696001647 Walker B motif; other site 710696001648 arginine finger; other site 710696001649 Peptidase family M41; Region: Peptidase_M41; pfam01434 710696001650 GTP cyclohydrolase I; Provisional; Region: PLN03044 710696001651 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 710696001652 homodecamer interface [polypeptide binding]; other site 710696001653 active site 710696001654 putative catalytic site residues [active] 710696001655 zinc binding site [ion binding]; other site 710696001656 GTP-CH-I/GFRP interaction surface; other site 710696001657 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 710696001658 dihydropteroate synthase; Region: DHPS; TIGR01496 710696001659 substrate binding pocket [chemical binding]; other site 710696001660 dimer interface [polypeptide binding]; other site 710696001661 inhibitor binding site; inhibition site 710696001662 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 710696001663 homooctamer interface [polypeptide binding]; other site 710696001664 active site 710696001665 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 710696001666 catalytic center binding site [active] 710696001667 ATP binding site [chemical binding]; other site 710696001668 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 710696001669 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 710696001670 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 710696001671 CopC domain; Region: CopC; pfam04234 710696001672 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 710696001673 Methyltransferase domain; Region: Methyltransf_32; pfam13679 710696001674 Rossmann-like domain; Region: Rossmann-like; pfam10727 710696001675 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 710696001676 pantoate--beta-alanine ligase; Region: panC; TIGR00018 710696001677 Pantoate-beta-alanine ligase; Region: PanC; cd00560 710696001678 active site 710696001679 ATP-binding site [chemical binding]; other site 710696001680 pantoate-binding site; other site 710696001681 HXXH motif; other site 710696001682 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 710696001683 tetramerization interface [polypeptide binding]; other site 710696001684 active site 710696001685 L-aspartate oxidase; Provisional; Region: PRK07804 710696001686 L-aspartate oxidase; Provisional; Region: PRK06175 710696001687 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 710696001688 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 710696001689 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 710696001690 dimerization interface [polypeptide binding]; other site 710696001691 active site 710696001692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696001693 S-adenosylmethionine binding site [chemical binding]; other site 710696001694 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 710696001695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696001696 ATP binding site [chemical binding]; other site 710696001697 Q-loop/lid; other site 710696001698 ABC transporter signature motif; other site 710696001699 Walker B; other site 710696001700 D-loop; other site 710696001701 H-loop/switch region; other site 710696001702 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710696001703 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 710696001704 exopolyphosphatase; Region: exo_poly_only; TIGR03706 710696001705 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 710696001706 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 710696001707 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 710696001708 DNA interaction; other site 710696001709 Metal-binding active site; metal-binding site 710696001710 short chain dehydrogenase; Provisional; Region: PRK08219 710696001711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696001712 NAD(P) binding site [chemical binding]; other site 710696001713 active site 710696001714 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 710696001715 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 710696001716 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 710696001717 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 710696001718 putative DNA binding site [nucleotide binding]; other site 710696001719 putative homodimer interface [polypeptide binding]; other site 710696001720 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 710696001721 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 710696001722 active site 710696001723 DNA binding site [nucleotide binding] 710696001724 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 710696001725 DNA binding site [nucleotide binding] 710696001726 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 710696001727 nucleotide binding site [chemical binding]; other site 710696001728 Lsr2; Region: Lsr2; pfam11774 710696001729 DNA repair protein RadA; Provisional; Region: PRK11823 710696001730 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 710696001731 Walker A motif; other site 710696001732 ATP binding site [chemical binding]; other site 710696001733 Walker B motif; other site 710696001734 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 710696001735 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 710696001736 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 710696001737 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 710696001738 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 710696001739 minor groove reading motif; other site 710696001740 helix-hairpin-helix signature motif; other site 710696001741 active site 710696001742 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 710696001743 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696001744 Coenzyme A binding pocket [chemical binding]; other site 710696001745 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 710696001746 Clp protease ATP binding subunit; Region: clpC; CHL00095 710696001747 Clp amino terminal domain; Region: Clp_N; pfam02861 710696001748 Clp amino terminal domain; Region: Clp_N; pfam02861 710696001749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696001750 Walker A motif; other site 710696001751 ATP binding site [chemical binding]; other site 710696001752 Walker B motif; other site 710696001753 arginine finger; other site 710696001754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696001755 Walker A motif; other site 710696001756 ATP binding site [chemical binding]; other site 710696001757 Walker B motif; other site 710696001758 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 710696001759 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 710696001760 nucleoside/Zn binding site; other site 710696001761 dimer interface [polypeptide binding]; other site 710696001762 catalytic motif [active] 710696001763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696001764 S-adenosylmethionine binding site [chemical binding]; other site 710696001765 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710696001766 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710696001767 Proline dehydrogenase; Region: Pro_dh; cl03282 710696001768 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 710696001769 pyrroline-5-carboxylate reductase; Region: PLN02688 710696001770 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710696001771 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710696001772 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 710696001773 TrkA-N domain; Region: TrkA_N; pfam02254 710696001774 TrkA-C domain; Region: TrkA_C; pfam02080 710696001775 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 710696001776 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 710696001777 active site 710696001778 Zn binding site [ion binding]; other site 710696001779 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 710696001780 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 710696001781 Dimer interface [polypeptide binding]; other site 710696001782 anticodon binding site; other site 710696001783 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710696001784 motif 1; other site 710696001785 dimer interface [polypeptide binding]; other site 710696001786 active site 710696001787 motif 2; other site 710696001788 motif 3; other site 710696001789 DNA binding domain, excisionase family; Region: excise; TIGR01764 710696001790 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710696001791 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 710696001792 putative NAD(P) binding site [chemical binding]; other site 710696001793 active site 710696001794 putative substrate binding site [chemical binding]; other site 710696001795 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710696001796 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 710696001797 putative acyl-acceptor binding pocket; other site 710696001798 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 710696001799 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696001800 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710696001801 DNA binding residues [nucleotide binding] 710696001802 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 710696001803 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 710696001804 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 710696001805 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 710696001806 CoA binding domain; Region: CoA_binding; pfam02629 710696001807 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 710696001808 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 710696001809 tRNA; other site 710696001810 putative tRNA binding site [nucleotide binding]; other site 710696001811 putative NADP binding site [chemical binding]; other site 710696001812 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 710696001813 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 710696001814 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 710696001815 domain interfaces; other site 710696001816 active site 710696001817 Uroporphyrinogen-III methylase [Coenzyme metabolism]; Region: CysG; COG0007 710696001818 homodimer interface [polypeptide binding]; other site 710696001819 active site 710696001820 SAM binding site [chemical binding]; other site 710696001821 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 710696001822 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 710696001823 active site 710696001824 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 710696001825 dimer interface [polypeptide binding]; other site 710696001826 active site 710696001827 Schiff base residues; other site 710696001828 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710696001829 MarR family; Region: MarR; pfam01047 710696001830 MarR family; Region: MarR_2; cl17246 710696001831 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 710696001832 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710696001833 inhibitor-cofactor binding pocket; inhibition site 710696001834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696001835 catalytic residue [active] 710696001836 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710696001837 catalytic core [active] 710696001838 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 710696001839 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710696001840 catalytic residues [active] 710696001841 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 710696001842 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 710696001843 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 710696001844 ResB-like family; Region: ResB; pfam05140 710696001845 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 710696001846 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 710696001847 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 710696001848 UbiA prenyltransferase family; Region: UbiA; pfam01040 710696001849 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 710696001850 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710696001851 acyl-activating enzyme (AAE) consensus motif; other site 710696001852 AMP binding site [chemical binding]; other site 710696001853 active site 710696001854 CoA binding site [chemical binding]; other site 710696001855 H+ Antiporter protein; Region: 2A0121; TIGR00900 710696001856 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 710696001857 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696001858 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 710696001859 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710696001860 substrate binding site [chemical binding]; other site 710696001861 oxyanion hole (OAH) forming residues; other site 710696001862 trimer interface [polypeptide binding]; other site 710696001863 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 710696001864 nudix motif; other site 710696001865 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 710696001866 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 710696001867 putative dimer interface [polypeptide binding]; other site 710696001868 active site pocket [active] 710696001869 putative cataytic base [active] 710696001870 O-succinylbenzoate synthase; Provisional; Region: PRK02901 710696001871 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 710696001872 active site 710696001873 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 710696001874 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 710696001875 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 710696001876 dimer interface [polypeptide binding]; other site 710696001877 tetramer interface [polypeptide binding]; other site 710696001878 PYR/PP interface [polypeptide binding]; other site 710696001879 TPP binding site [chemical binding]; other site 710696001880 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 710696001881 TPP-binding site; other site 710696001882 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 710696001883 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 710696001884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696001885 S-adenosylmethionine binding site [chemical binding]; other site 710696001886 NADH dehydrogenase subunit A; Validated; Region: PRK07928 710696001887 NADH dehydrogenase subunit B; Validated; Region: PRK06411 710696001888 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 710696001889 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 710696001890 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 710696001891 NADH dehydrogenase subunit D; Validated; Region: PRK06075 710696001892 NADH dehydrogenase subunit E; Validated; Region: PRK07539 710696001893 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 710696001894 putative dimer interface [polypeptide binding]; other site 710696001895 [2Fe-2S] cluster binding site [ion binding]; other site 710696001896 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 710696001897 SLBB domain; Region: SLBB; pfam10531 710696001898 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 710696001899 NADH dehydrogenase subunit G; Validated; Region: PRK07860 710696001900 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710696001901 catalytic loop [active] 710696001902 iron binding site [ion binding]; other site 710696001903 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 710696001904 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710696001905 molybdopterin cofactor binding site; other site 710696001906 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710696001907 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 710696001908 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 710696001909 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 710696001910 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 710696001911 4Fe-4S binding domain; Region: Fer4; pfam00037 710696001912 4Fe-4S binding domain; Region: Fer4; pfam00037 710696001913 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 710696001914 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 710696001915 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 710696001916 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 710696001917 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 710696001918 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710696001919 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 710696001920 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710696001921 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 710696001922 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710696001923 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 710696001924 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 710696001925 substrate binding pocket [chemical binding]; other site 710696001926 chain length determination region; other site 710696001927 substrate-Mg2+ binding site; other site 710696001928 catalytic residues [active] 710696001929 aspartate-rich region 1; other site 710696001930 active site lid residues [active] 710696001931 aspartate-rich region 2; other site 710696001932 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 710696001933 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 710696001934 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710696001935 catalytic residue [active] 710696001936 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 710696001937 FAD binding domain; Region: FAD_binding_4; pfam01565 710696001938 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 710696001939 fumarate hydratase; Reviewed; Region: fumC; PRK00485 710696001940 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 710696001941 active sites [active] 710696001942 tetramer interface [polypeptide binding]; other site 710696001943 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 710696001944 propionate/acetate kinase; Provisional; Region: PRK12379 710696001945 phosphate acetyltransferase; Reviewed; Region: PRK05632 710696001946 DRTGG domain; Region: DRTGG; pfam07085 710696001947 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 710696001948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696001949 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 710696001950 putative substrate translocation pore; other site 710696001951 Predicted permeases [General function prediction only]; Region: RarD; COG2962 710696001952 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 710696001953 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 710696001954 TPP-binding site [chemical binding]; other site 710696001955 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 710696001956 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 710696001957 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 710696001958 dimer interface [polypeptide binding]; other site 710696001959 PYR/PP interface [polypeptide binding]; other site 710696001960 TPP binding site [chemical binding]; other site 710696001961 substrate binding site [chemical binding]; other site 710696001962 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 710696001963 NADH dehydrogenase subunit B; Validated; Region: PRK06411 710696001964 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 710696001965 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 710696001966 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 710696001967 4Fe-4S binding domain; Region: Fer4; pfam00037 710696001968 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 710696001969 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 710696001970 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710696001971 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710696001972 NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007 710696001973 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710696001974 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 710696001975 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 710696001976 heat shock protein HtpX; Provisional; Region: PRK03072 710696001977 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 710696001978 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 710696001979 Zn binding site [ion binding]; other site 710696001980 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710696001981 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710696001982 active site 710696001983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696001984 NAD(P) binding site [chemical binding]; other site 710696001985 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696001986 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710696001987 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 710696001988 protein binding site [polypeptide binding]; other site 710696001989 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710696001990 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710696001991 dimerization interface [polypeptide binding]; other site 710696001992 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710696001993 dimer interface [polypeptide binding]; other site 710696001994 phosphorylation site [posttranslational modification] 710696001995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696001996 ATP binding site [chemical binding]; other site 710696001997 Mg2+ binding site [ion binding]; other site 710696001998 G-X-G motif; other site 710696001999 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710696002000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696002001 active site 710696002002 phosphorylation site [posttranslational modification] 710696002003 intermolecular recognition site; other site 710696002004 dimerization interface [polypeptide binding]; other site 710696002005 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710696002006 DNA binding site [nucleotide binding] 710696002007 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 710696002008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696002009 Walker A/P-loop; other site 710696002010 ATP binding site [chemical binding]; other site 710696002011 Q-loop/lid; other site 710696002012 ABC transporter signature motif; other site 710696002013 Walker B; other site 710696002014 D-loop; other site 710696002015 H-loop/switch region; other site 710696002016 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 710696002017 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 710696002018 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 710696002019 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710696002020 ATP binding site [chemical binding]; other site 710696002021 putative Mg++ binding site [ion binding]; other site 710696002022 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710696002023 nucleotide binding region [chemical binding]; other site 710696002024 ATP-binding site [chemical binding]; other site 710696002025 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 710696002026 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 710696002027 active site 710696002028 catalytic residues [active] 710696002029 metal binding site [ion binding]; metal-binding site 710696002030 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 710696002031 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 710696002032 active site 710696002033 catalytic residues [active] 710696002034 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 710696002035 DNA-binding site [nucleotide binding]; DNA binding site 710696002036 RNA-binding motif; other site 710696002037 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 710696002038 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 710696002039 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710696002040 MarR family; Region: MarR; pfam01047 710696002041 H+ Antiporter protein; Region: 2A0121; TIGR00900 710696002042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696002043 putative substrate translocation pore; other site 710696002044 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 710696002045 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710696002046 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710696002047 catalytic residue [active] 710696002048 citrate synthase 2; Provisional; Region: PRK12350 710696002049 Citrate synthase; Region: Citrate_synt; pfam00285 710696002050 oxalacetate binding site [chemical binding]; other site 710696002051 citrylCoA binding site [chemical binding]; other site 710696002052 coenzyme A binding site [chemical binding]; other site 710696002053 catalytic triad [active] 710696002054 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 710696002055 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 710696002056 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 710696002057 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 710696002058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696002059 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710696002060 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 710696002061 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 710696002062 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 710696002063 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710696002064 NlpC/P60 family; Region: NLPC_P60; pfam00877 710696002065 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 710696002066 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 710696002067 catalytic residues [active] 710696002068 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710696002069 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 710696002070 anti sigma factor interaction site; other site 710696002071 regulatory phosphorylation site [posttranslational modification]; other site 710696002072 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 710696002073 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710696002074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 710696002075 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710696002076 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710696002077 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710696002078 dimerization interface [polypeptide binding]; other site 710696002079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710696002080 dimer interface [polypeptide binding]; other site 710696002081 phosphorylation site [posttranslational modification] 710696002082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696002083 ATP binding site [chemical binding]; other site 710696002084 Mg2+ binding site [ion binding]; other site 710696002085 G-X-G motif; other site 710696002086 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710696002087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696002088 active site 710696002089 phosphorylation site [posttranslational modification] 710696002090 intermolecular recognition site; other site 710696002091 dimerization interface [polypeptide binding]; other site 710696002092 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710696002093 DNA binding site [nucleotide binding] 710696002094 Predicted membrane protein [Function unknown]; Region: COG3462 710696002095 Short C-terminal domain; Region: SHOCT; pfam09851 710696002096 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 710696002097 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 710696002098 metal-binding site [ion binding] 710696002099 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710696002100 Soluble P-type ATPase [General function prediction only]; Region: COG4087 710696002101 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 710696002102 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 710696002103 [4Fe-4S] binding site [ion binding]; other site 710696002104 molybdopterin cofactor binding site; other site 710696002105 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 710696002106 molybdopterin cofactor binding site; other site 710696002107 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 710696002108 putative active site; other site 710696002109 putative metal binding residues [ion binding]; other site 710696002110 signature motif; other site 710696002111 putative triphosphate binding site [ion binding]; other site 710696002112 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 710696002113 Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579 710696002114 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 710696002115 active site 710696002116 SAM binding site [chemical binding]; other site 710696002117 homodimer interface [polypeptide binding]; other site 710696002118 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 710696002119 homodimer interface [polypeptide binding]; other site 710696002120 active site 710696002121 SAM binding site [chemical binding]; other site 710696002122 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 710696002123 Precorrin-8X methylmutase; Region: CbiC; pfam02570 710696002124 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710696002125 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 710696002126 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710696002127 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710696002128 SnoaL-like domain; Region: SnoaL_3; pfam13474 710696002129 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710696002130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696002131 S-adenosylmethionine binding site [chemical binding]; other site 710696002132 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 710696002133 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 710696002134 active site 710696002135 catalytic residues [active] 710696002136 DNA binding site [nucleotide binding] 710696002137 Int/Topo IB signature motif; other site 710696002138 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 710696002139 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710696002140 active site 710696002141 DNA binding site [nucleotide binding] 710696002142 Int/Topo IB signature motif; other site 710696002143 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710696002144 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710696002145 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710696002146 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 710696002147 active site 710696002148 catalytic triad [active] 710696002149 oxyanion hole [active] 710696002150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 710696002151 Transposase; Region: DDE_Tnp_ISL3; pfam01610 710696002152 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710696002153 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710696002154 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710696002155 precorrin-3B synthase; Region: CobG; TIGR02435 710696002156 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 710696002157 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 710696002158 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 710696002159 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 710696002160 active site 710696002161 SAM binding site [chemical binding]; other site 710696002162 homodimer interface [polypeptide binding]; other site 710696002163 cobyric acid synthase; Provisional; Region: PRK00784 710696002164 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 710696002165 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 710696002166 catalytic triad [active] 710696002167 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 710696002168 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 710696002169 active site 710696002170 SAM binding site [chemical binding]; other site 710696002171 homodimer interface [polypeptide binding]; other site 710696002172 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 710696002173 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710696002174 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 710696002175 catalytic triad [active] 710696002176 hypothetical protein; Provisional; Region: PRK07908 710696002177 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710696002178 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696002179 homodimer interface [polypeptide binding]; other site 710696002180 catalytic residue [active] 710696002181 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 710696002182 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 710696002183 homodimer interface [polypeptide binding]; other site 710696002184 Walker A motif; other site 710696002185 ATP binding site [chemical binding]; other site 710696002186 hydroxycobalamin binding site [chemical binding]; other site 710696002187 Walker B motif; other site 710696002188 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 710696002189 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 710696002190 metal ion-dependent adhesion site (MIDAS); other site 710696002191 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 710696002192 active site 710696002193 putative homodimer interface [polypeptide binding]; other site 710696002194 SAM binding site [chemical binding]; other site 710696002195 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 710696002196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696002197 S-adenosylmethionine binding site [chemical binding]; other site 710696002198 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 710696002199 active site 710696002200 SAM binding site [chemical binding]; other site 710696002201 homodimer interface [polypeptide binding]; other site 710696002202 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 710696002203 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 710696002204 cobalt transport protein CbiN; Provisional; Region: PRK02898 710696002205 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 710696002206 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 710696002207 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 710696002208 Walker A/P-loop; other site 710696002209 ATP binding site [chemical binding]; other site 710696002210 Q-loop/lid; other site 710696002211 ABC transporter signature motif; other site 710696002212 Walker B; other site 710696002213 D-loop; other site 710696002214 H-loop/switch region; other site 710696002215 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 710696002216 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 710696002217 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 710696002218 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 710696002219 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 710696002220 Cysteine-rich domain; Region: CCG; pfam02754 710696002221 Cysteine-rich domain; Region: CCG; pfam02754 710696002222 L-lactate permease; Region: Lactate_perm; cl00701 710696002223 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 710696002224 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710696002225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 710696002226 DNA-binding site [nucleotide binding]; DNA binding site 710696002227 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 710696002228 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 710696002229 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 710696002230 Domain of unknown function DUF21; Region: DUF21; pfam01595 710696002231 FOG: CBS domain [General function prediction only]; Region: COG0517 710696002232 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 710696002233 Domain of unknown function DUF21; Region: DUF21; pfam01595 710696002234 hypothetical protein; Provisional; Region: PRK11573 710696002235 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 710696002236 Transporter associated domain; Region: CorC_HlyC; pfam03471 710696002237 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 710696002238 putative active site [active] 710696002239 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 710696002240 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 710696002241 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 710696002242 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 710696002243 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 710696002244 dimer interface [polypeptide binding]; other site 710696002245 active site 710696002246 citrylCoA binding site [chemical binding]; other site 710696002247 NADH binding [chemical binding]; other site 710696002248 cationic pore residues; other site 710696002249 oxalacetate/citrate binding site [chemical binding]; other site 710696002250 coenzyme A binding site [chemical binding]; other site 710696002251 catalytic triad [active] 710696002252 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710696002253 hydroxyglutarate oxidase; Provisional; Region: PRK11728 710696002254 malate synthase A; Region: malate_syn_A; TIGR01344 710696002255 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 710696002256 active site 710696002257 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 710696002258 FAD binding domain; Region: FAD_binding_4; pfam01565 710696002259 5' nucleotidase family; Region: 5_nucleotid; cl17687 710696002260 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710696002261 FAD binding domain; Region: FAD_binding_4; pfam01565 710696002262 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 710696002263 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 710696002264 Cysteine-rich domain; Region: CCG; pfam02754 710696002265 Cysteine-rich domain; Region: CCG; pfam02754 710696002266 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 710696002267 L-lactate permease; Region: Lactate_perm; cl00701 710696002268 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 710696002269 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710696002270 Bacterial transcriptional regulator; Region: IclR; pfam01614 710696002271 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710696002272 HAMP domain; Region: HAMP; pfam00672 710696002273 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710696002274 dimer interface [polypeptide binding]; other site 710696002275 phosphorylation site [posttranslational modification] 710696002276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696002277 ATP binding site [chemical binding]; other site 710696002278 Mg2+ binding site [ion binding]; other site 710696002279 G-X-G motif; other site 710696002280 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710696002281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696002282 active site 710696002283 phosphorylation site [posttranslational modification] 710696002284 intermolecular recognition site; other site 710696002285 dimerization interface [polypeptide binding]; other site 710696002286 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710696002287 DNA binding site [nucleotide binding] 710696002288 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 710696002289 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 710696002290 Walker A/P-loop; other site 710696002291 ATP binding site [chemical binding]; other site 710696002292 Q-loop/lid; other site 710696002293 ABC transporter signature motif; other site 710696002294 Walker B; other site 710696002295 D-loop; other site 710696002296 H-loop/switch region; other site 710696002297 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 710696002298 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 710696002299 active site 710696002300 ATP binding site [chemical binding]; other site 710696002301 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 710696002302 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710696002303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696002304 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710696002305 Cytochrome P450; Region: p450; cl12078 710696002306 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710696002307 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 710696002308 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710696002309 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710696002310 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710696002311 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 710696002312 substrate binding pocket [chemical binding]; other site 710696002313 dimerization interface [polypeptide binding]; other site 710696002314 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696002315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696002316 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710696002317 putative substrate translocation pore; other site 710696002318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696002319 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710696002320 active site 710696002321 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710696002322 active site 710696002323 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710696002324 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710696002325 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710696002326 substrate binding pocket [chemical binding]; other site 710696002327 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710696002328 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 710696002329 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 710696002330 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710696002331 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 710696002332 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 710696002333 active site 710696002334 Coenzyme A transferase; Region: CoA_trans; cl17247 710696002335 Coenzyme A transferase; Region: CoA_trans; cl17247 710696002336 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 710696002337 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 710696002338 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 710696002339 amphipathic channel; other site 710696002340 Asn-Pro-Ala signature motifs; other site 710696002341 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 710696002342 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 710696002343 NAD binding site [chemical binding]; other site 710696002344 catalytic Zn binding site [ion binding]; other site 710696002345 structural Zn binding site [ion binding]; other site 710696002346 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 710696002347 Integrase core domain; Region: rve; pfam00665 710696002348 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 710696002349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696002350 Walker A motif; other site 710696002351 ATP binding site [chemical binding]; other site 710696002352 Walker B motif; other site 710696002353 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 710696002354 active site 710696002355 NTP binding site [chemical binding]; other site 710696002356 metal binding triad [ion binding]; metal-binding site 710696002357 antibiotic binding site [chemical binding]; other site 710696002358 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710696002359 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696002360 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710696002361 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 710696002362 putative NAD(P) binding site [chemical binding]; other site 710696002363 Protein of unknown function (DUF497); Region: DUF497; cl01108 710696002364 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 710696002365 TAP-like protein; Region: Abhydrolase_4; pfam08386 710696002366 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 710696002367 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 710696002368 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710696002369 active site 710696002370 DNA binding site [nucleotide binding] 710696002371 Int/Topo IB signature motif; other site 710696002372 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710696002373 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 710696002374 active site 710696002375 DNA binding site [nucleotide binding] 710696002376 Int/Topo IB signature motif; other site 710696002377 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 710696002378 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710696002379 active site 710696002380 DNA binding site [nucleotide binding] 710696002381 Int/Topo IB signature motif; other site 710696002382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 710696002383 Transposase; Region: DDE_Tnp_ISL3; pfam01610 710696002384 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 710696002385 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 710696002386 putative active site [active] 710696002387 putative NTP binding site [chemical binding]; other site 710696002388 putative nucleic acid binding site [nucleotide binding]; other site 710696002389 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 710696002390 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710696002391 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710696002392 homodimer interface [polypeptide binding]; other site 710696002393 active site 710696002394 TDP-binding site; other site 710696002395 acceptor substrate-binding pocket; other site 710696002396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710696002397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696002398 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 710696002399 active site 710696002400 Zn binding site [ion binding]; other site 710696002401 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 710696002402 Part of AAA domain; Region: AAA_19; pfam13245 710696002403 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 710696002404 AAA domain; Region: AAA_12; pfam13087 710696002405 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 710696002406 putative active site [active] 710696002407 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 710696002408 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 710696002409 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 710696002410 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 710696002411 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 710696002412 potassium/proton antiporter; Reviewed; Region: PRK05326 710696002413 TrkA-C domain; Region: TrkA_C; pfam02080 710696002414 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 710696002415 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 710696002416 active site 710696002417 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 710696002418 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 710696002419 active site 710696002420 substrate binding site; other site 710696002421 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 710696002422 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 710696002423 dimer interface [polypeptide binding]; other site 710696002424 putative functional site; other site 710696002425 putative MPT binding site; other site 710696002426 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 710696002427 trimer interface [polypeptide binding]; other site 710696002428 dimer interface [polypeptide binding]; other site 710696002429 putative active site [active] 710696002430 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 710696002431 MPT binding site; other site 710696002432 trimer interface [polypeptide binding]; other site 710696002433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710696002434 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 710696002435 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 710696002436 Domain of unknown function DUF20; Region: UPF0118; pfam01594 710696002437 Protein of unknown function DUF72; Region: DUF72; pfam01904 710696002438 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710696002439 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 710696002440 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710696002441 putative NAD(P) binding site [chemical binding]; other site 710696002442 catalytic Zn binding site [ion binding]; other site 710696002443 structural Zn binding site [ion binding]; other site 710696002444 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 710696002445 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 710696002446 CAAX protease self-immunity; Region: Abi; pfam02517 710696002447 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 710696002448 Predicted methyltransferases [General function prediction only]; Region: COG0313 710696002449 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 710696002450 putative SAM binding site [chemical binding]; other site 710696002451 putative homodimer interface [polypeptide binding]; other site 710696002452 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 710696002453 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 710696002454 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 710696002455 active site 710696002456 HIGH motif; other site 710696002457 KMSKS motif; other site 710696002458 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 710696002459 tRNA binding surface [nucleotide binding]; other site 710696002460 anticodon binding site; other site 710696002461 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 710696002462 active site 710696002463 Domain of unknown function (DUF348); Region: DUF348; pfam03990 710696002464 Domain of unknown function (DUF348); Region: DUF348; pfam03990 710696002465 G5 domain; Region: G5; pfam07501 710696002466 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 710696002467 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 710696002468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696002469 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 710696002470 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 710696002471 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 710696002472 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 710696002473 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710696002474 ABC transporter; Region: ABC_tran_2; pfam12848 710696002475 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710696002476 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 710696002477 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 710696002478 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 710696002479 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 710696002480 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 710696002481 Zn binding site [ion binding]; other site 710696002482 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 710696002483 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 710696002484 sugar binding site [chemical binding]; other site 710696002485 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710696002486 MarR family; Region: MarR_2; cl17246 710696002487 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 710696002488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696002489 S-adenosylmethionine binding site [chemical binding]; other site 710696002490 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710696002491 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696002492 Putative zinc-finger; Region: zf-HC2; pfam13490 710696002493 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710696002494 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696002495 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 710696002496 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 710696002497 Substrate binding site; other site 710696002498 Mg++ binding site; other site 710696002499 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 710696002500 active site 710696002501 substrate binding site [chemical binding]; other site 710696002502 CoA binding site [chemical binding]; other site 710696002503 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 710696002504 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 710696002505 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710696002506 active site 710696002507 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 710696002508 CGNR zinc finger; Region: zf-CGNR; pfam11706 710696002509 EamA-like transporter family; Region: EamA; pfam00892 710696002510 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 710696002511 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 710696002512 5S rRNA interface [nucleotide binding]; other site 710696002513 CTC domain interface [polypeptide binding]; other site 710696002514 L16 interface [polypeptide binding]; other site 710696002515 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 710696002516 putative active site [active] 710696002517 catalytic residue [active] 710696002518 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 710696002519 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 710696002520 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710696002521 ATP binding site [chemical binding]; other site 710696002522 putative Mg++ binding site [ion binding]; other site 710696002523 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710696002524 nucleotide binding region [chemical binding]; other site 710696002525 ATP-binding site [chemical binding]; other site 710696002526 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 710696002527 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 710696002528 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 710696002529 homodimer interface [polypeptide binding]; other site 710696002530 metal binding site [ion binding]; metal-binding site 710696002531 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 710696002532 Bacterial sugar transferase; Region: Bac_transf; pfam02397 710696002533 enolase; Provisional; Region: eno; PRK00077 710696002534 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 710696002535 dimer interface [polypeptide binding]; other site 710696002536 metal binding site [ion binding]; metal-binding site 710696002537 substrate binding pocket [chemical binding]; other site 710696002538 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 710696002539 Septum formation initiator; Region: DivIC; pfam04977 710696002540 Protein of unknown function (DUF501); Region: DUF501; cl00652 710696002541 exopolyphosphatase; Region: exo_poly_only; TIGR03706 710696002542 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 710696002543 Bax inhibitor 1 like; Region: BaxI_1; cl17691 710696002544 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 710696002545 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710696002546 dimer interface [polypeptide binding]; other site 710696002547 active site 710696002548 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 710696002549 active site 710696002550 catalytic triad [active] 710696002551 oxyanion hole [active] 710696002552 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 710696002553 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 710696002554 dimer interface [polypeptide binding]; other site 710696002555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696002556 catalytic residue [active] 710696002557 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 710696002558 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 710696002559 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710696002560 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710696002561 DNA binding residues [nucleotide binding] 710696002562 dimerization interface [polypeptide binding]; other site 710696002563 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 710696002564 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 710696002565 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 710696002566 calcium binding site 2 [ion binding]; other site 710696002567 active site 710696002568 catalytic triad [active] 710696002569 calcium binding site 1 [ion binding]; other site 710696002570 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 710696002571 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 710696002572 dimer interface [polypeptide binding]; other site 710696002573 active site 710696002574 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 710696002575 dimer interface [polypeptide binding]; other site 710696002576 active site 710696002577 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710696002578 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710696002579 DNA-binding site [nucleotide binding]; DNA binding site 710696002580 FCD domain; Region: FCD; pfam07729 710696002581 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 710696002582 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 710696002583 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 710696002584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696002585 dimer interface [polypeptide binding]; other site 710696002586 conserved gate region; other site 710696002587 putative PBP binding loops; other site 710696002588 ABC-ATPase subunit interface; other site 710696002589 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 710696002590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696002591 dimer interface [polypeptide binding]; other site 710696002592 conserved gate region; other site 710696002593 putative PBP binding loops; other site 710696002594 ABC-ATPase subunit interface; other site 710696002595 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 710696002596 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710696002597 Walker A/P-loop; other site 710696002598 ATP binding site [chemical binding]; other site 710696002599 Q-loop/lid; other site 710696002600 ABC transporter signature motif; other site 710696002601 Walker B; other site 710696002602 D-loop; other site 710696002603 H-loop/switch region; other site 710696002604 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710696002605 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710696002606 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 710696002607 Walker A/P-loop; other site 710696002608 ATP binding site [chemical binding]; other site 710696002609 Q-loop/lid; other site 710696002610 ABC transporter signature motif; other site 710696002611 Walker B; other site 710696002612 D-loop; other site 710696002613 H-loop/switch region; other site 710696002614 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710696002615 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 710696002616 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 710696002617 inhibitor site; inhibition site 710696002618 active site 710696002619 dimer interface [polypeptide binding]; other site 710696002620 catalytic residue [active] 710696002621 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 710696002622 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710696002623 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 710696002624 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 710696002625 putative active site cavity [active] 710696002626 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710696002627 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710696002628 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 710696002629 Uncharacterized conserved protein [Function unknown]; Region: COG1739 710696002630 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 710696002631 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 710696002632 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 710696002633 CrcB-like protein; Region: CRCB; cl09114 710696002634 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 710696002635 putative active site [active] 710696002636 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 710696002637 active site 710696002638 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 710696002639 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710696002640 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 710696002641 cyclase homology domain; Region: CHD; cd07302 710696002642 nucleotidyl binding site; other site 710696002643 metal binding site [ion binding]; metal-binding site 710696002644 dimer interface [polypeptide binding]; other site 710696002645 Hemerythrin-like domain; Region: Hr-like; cd12108 710696002646 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 710696002647 pentamer interface [polypeptide binding]; other site 710696002648 dodecaamer interface [polypeptide binding]; other site 710696002649 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710696002650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696002651 active site 710696002652 phosphorylation site [posttranslational modification] 710696002653 intermolecular recognition site; other site 710696002654 dimerization interface [polypeptide binding]; other site 710696002655 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710696002656 DNA binding residues [nucleotide binding] 710696002657 dimerization interface [polypeptide binding]; other site 710696002658 Histidine kinase; Region: HisKA_3; pfam07730 710696002659 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 710696002660 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 710696002661 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 710696002662 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 710696002663 ATP binding site [chemical binding]; other site 710696002664 Mg++ binding site [ion binding]; other site 710696002665 motif III; other site 710696002666 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710696002667 nucleotide binding region [chemical binding]; other site 710696002668 ATP-binding site [chemical binding]; other site 710696002669 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 710696002670 putative RNA binding site [nucleotide binding]; other site 710696002671 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710696002672 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710696002673 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 710696002674 active site 710696002675 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 710696002676 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 710696002677 NADP binding site [chemical binding]; other site 710696002678 acyl-CoA esterase; Provisional; Region: PRK10673 710696002679 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 710696002680 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710696002681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696002682 active site 710696002683 phosphorylation site [posttranslational modification] 710696002684 intermolecular recognition site; other site 710696002685 dimerization interface [polypeptide binding]; other site 710696002686 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710696002687 DNA binding residues [nucleotide binding] 710696002688 dimerization interface [polypeptide binding]; other site 710696002689 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710696002690 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 710696002691 ATP binding site [chemical binding]; other site 710696002692 Mg2+ binding site [ion binding]; other site 710696002693 G-X-G motif; other site 710696002694 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 710696002695 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 710696002696 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 710696002697 active site 710696002698 Zn binding site [ion binding]; other site 710696002699 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 710696002700 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696002701 Coenzyme A binding pocket [chemical binding]; other site 710696002702 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 710696002703 putative hydrophobic ligand binding site [chemical binding]; other site 710696002704 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 710696002705 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 710696002706 AAA ATPase domain; Region: AAA_16; pfam13191 710696002707 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710696002708 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710696002709 DNA binding residues [nucleotide binding] 710696002710 dimerization interface [polypeptide binding]; other site 710696002711 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 710696002712 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710696002713 FAD binding domain; Region: FAD_binding_4; pfam01565 710696002714 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 710696002715 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 710696002716 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710696002717 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710696002718 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 710696002719 putative dimerization interface [polypeptide binding]; other site 710696002720 methionine sulfoxide reductase A; Provisional; Region: PRK00058 710696002721 cystathionine gamma-synthase; Provisional; Region: PRK07811 710696002722 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 710696002723 homodimer interface [polypeptide binding]; other site 710696002724 substrate-cofactor binding pocket; other site 710696002725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696002726 catalytic residue [active] 710696002727 MutL protein; Region: MutL; pfam13941 710696002728 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 710696002729 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 710696002730 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 710696002731 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 710696002732 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 710696002733 Haemolysin-III related; Region: HlyIII; pfam03006 710696002734 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 710696002735 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 710696002736 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 710696002737 catalytic residue [active] 710696002738 putative FPP diphosphate binding site; other site 710696002739 putative FPP binding hydrophobic cleft; other site 710696002740 dimer interface [polypeptide binding]; other site 710696002741 putative IPP diphosphate binding site; other site 710696002742 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 710696002743 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 710696002744 putative active site [active] 710696002745 PhoH-like protein; Region: PhoH; pfam02562 710696002746 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 710696002747 N-acetyl-D-glucosamine binding site [chemical binding]; other site 710696002748 catalytic residue [active] 710696002749 pantothenate kinase; Provisional; Region: PRK05439 710696002750 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 710696002751 ATP-binding site [chemical binding]; other site 710696002752 CoA-binding site [chemical binding]; other site 710696002753 Mg2+-binding site [ion binding]; other site 710696002754 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 710696002755 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 710696002756 glutaminase active site [active] 710696002757 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 710696002758 dimer interface [polypeptide binding]; other site 710696002759 active site 710696002760 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 710696002761 dimer interface [polypeptide binding]; other site 710696002762 active site 710696002763 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 710696002764 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 710696002765 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 710696002766 putative substrate binding site [chemical binding]; other site 710696002767 putative ATP binding site [chemical binding]; other site 710696002768 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 710696002769 alanine racemase; Reviewed; Region: alr; PRK00053 710696002770 active site 710696002771 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710696002772 dimer interface [polypeptide binding]; other site 710696002773 substrate binding site [chemical binding]; other site 710696002774 catalytic residues [active] 710696002775 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710696002776 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710696002777 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 710696002778 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 710696002779 Glycoprotease family; Region: Peptidase_M22; pfam00814 710696002780 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 710696002781 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710696002782 UGMP family protein; Validated; Region: PRK09604 710696002783 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 710696002784 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 710696002785 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 710696002786 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 710696002787 active site 710696002788 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710696002789 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 710696002790 ATP binding site [chemical binding]; other site 710696002791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710696002792 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 710696002793 oligomerisation interface [polypeptide binding]; other site 710696002794 mobile loop; other site 710696002795 roof hairpin; other site 710696002796 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 710696002797 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 710696002798 ring oligomerisation interface [polypeptide binding]; other site 710696002799 ATP/Mg binding site [chemical binding]; other site 710696002800 stacking interactions; other site 710696002801 hinge regions; other site 710696002802 Transcription factor WhiB; Region: Whib; pfam02467 710696002803 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696002804 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710696002805 DNA binding residues [nucleotide binding] 710696002806 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 710696002807 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710696002808 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 710696002809 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 710696002810 active site 710696002811 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 710696002812 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 710696002813 active site 710696002814 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 710696002815 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 710696002816 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710696002817 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 710696002818 putative NAD(P) binding site [chemical binding]; other site 710696002819 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 710696002820 active site 710696002821 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710696002822 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696002823 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 710696002824 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 710696002825 RibD C-terminal domain; Region: RibD_C; cl17279 710696002826 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 710696002827 dimerization interface [polypeptide binding]; other site 710696002828 active site 710696002829 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 710696002830 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 710696002831 GMP synthase; Reviewed; Region: guaA; PRK00074 710696002832 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 710696002833 AMP/PPi binding site [chemical binding]; other site 710696002834 candidate oxyanion hole; other site 710696002835 catalytic triad [active] 710696002836 potential glutamine specificity residues [chemical binding]; other site 710696002837 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 710696002838 ATP Binding subdomain [chemical binding]; other site 710696002839 Ligand Binding sites [chemical binding]; other site 710696002840 Dimerization subdomain; other site 710696002841 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 710696002842 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 710696002843 active site 710696002844 dimer interface [polypeptide binding]; other site 710696002845 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 710696002846 Ligand Binding Site [chemical binding]; other site 710696002847 Molecular Tunnel; other site 710696002848 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 710696002849 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 710696002850 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 710696002851 acyl-activating enzyme (AAE) consensus motif; other site 710696002852 putative AMP binding site [chemical binding]; other site 710696002853 putative active site [active] 710696002854 putative CoA binding site [chemical binding]; other site 710696002855 Predicted integral membrane protein [Function unknown]; Region: COG0392 710696002856 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 710696002857 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 710696002858 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710696002859 Walker A/P-loop; other site 710696002860 ATP binding site [chemical binding]; other site 710696002861 Q-loop/lid; other site 710696002862 ABC transporter signature motif; other site 710696002863 Walker B; other site 710696002864 D-loop; other site 710696002865 H-loop/switch region; other site 710696002866 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 710696002867 Transposase; Region: DDE_Tnp_ISL3; pfam01610 710696002868 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696002869 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710696002870 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 710696002871 nudix motif; other site 710696002872 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710696002873 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710696002874 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 710696002875 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 710696002876 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 710696002877 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 710696002878 active site 710696002879 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 710696002880 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 710696002881 NADP binding site [chemical binding]; other site 710696002882 dimer interface [polypeptide binding]; other site 710696002883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696002884 Coenzyme A binding pocket [chemical binding]; other site 710696002885 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 710696002886 Part of AAA domain; Region: AAA_19; pfam13245 710696002887 Protein of unknown function DUF137; Region: DUF137; cl03400 710696002888 Family description; Region: UvrD_C_2; pfam13538 710696002889 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 710696002890 Peptidase family M23; Region: Peptidase_M23; pfam01551 710696002891 Lipase (class 2); Region: Lipase_2; pfam01674 710696002892 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 710696002893 B12 binding site [chemical binding]; other site 710696002894 cobalt ligand [ion binding]; other site 710696002895 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 710696002896 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 710696002897 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 710696002898 Thioredoxin; Region: Thioredoxin_4; pfam13462 710696002899 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696002900 dimerization interface [polypeptide binding]; other site 710696002901 putative DNA binding site [nucleotide binding]; other site 710696002902 putative Zn2+ binding site [ion binding]; other site 710696002903 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710696002904 active site residue [active] 710696002905 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 710696002906 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 710696002907 CoA-ligase; Region: Ligase_CoA; pfam00549 710696002908 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 710696002909 CoA binding domain; Region: CoA_binding; smart00881 710696002910 CoA-ligase; Region: Ligase_CoA; pfam00549 710696002911 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 710696002912 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 710696002913 active site 710696002914 substrate binding site [chemical binding]; other site 710696002915 cosubstrate binding site; other site 710696002916 catalytic site [active] 710696002917 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 710696002918 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 710696002919 purine monophosphate binding site [chemical binding]; other site 710696002920 dimer interface [polypeptide binding]; other site 710696002921 putative catalytic residues [active] 710696002922 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 710696002923 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 710696002924 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 710696002925 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 710696002926 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 710696002927 putative substrate binding site [chemical binding]; other site 710696002928 nucleotide binding site [chemical binding]; other site 710696002929 nucleotide binding site [chemical binding]; other site 710696002930 homodimer interface [polypeptide binding]; other site 710696002931 MMPL family; Region: MMPL; pfam03176 710696002932 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710696002933 MarR family; Region: MarR; pfam01047 710696002934 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 710696002935 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 710696002936 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 710696002937 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 710696002938 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 710696002939 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710696002940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696002941 active site 710696002942 phosphorylation site [posttranslational modification] 710696002943 intermolecular recognition site; other site 710696002944 dimerization interface [polypeptide binding]; other site 710696002945 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710696002946 DNA binding site [nucleotide binding] 710696002947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710696002948 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710696002949 dimerization interface [polypeptide binding]; other site 710696002950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710696002951 dimer interface [polypeptide binding]; other site 710696002952 phosphorylation site [posttranslational modification] 710696002953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696002954 ATP binding site [chemical binding]; other site 710696002955 Mg2+ binding site [ion binding]; other site 710696002956 G-X-G motif; other site 710696002957 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 710696002958 dinuclear metal binding motif [ion binding]; other site 710696002959 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710696002960 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710696002961 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710696002962 active site residue [active] 710696002963 N-carbamolyputrescine amidase; Region: PLN02747 710696002964 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 710696002965 active site 710696002966 catalytic triad [active] 710696002967 dimer interface [polypeptide binding]; other site 710696002968 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 710696002969 putative hydrophobic ligand binding site [chemical binding]; other site 710696002970 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 710696002971 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 710696002972 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 710696002973 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 710696002974 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 710696002975 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 710696002976 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 710696002977 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 710696002978 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 710696002979 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710696002980 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 710696002981 membrane protein FdrA; Validated; Region: PRK06091 710696002982 CoA-ligase; Region: Ligase_CoA; pfam00549 710696002983 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 710696002984 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 710696002985 DNA-binding site [nucleotide binding]; DNA binding site 710696002986 RNA-binding motif; other site 710696002987 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 710696002988 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710696002989 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710696002990 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 710696002991 NAD binding site [chemical binding]; other site 710696002992 catalytic residues [active] 710696002993 Tautomerase enzyme; Region: Tautomerase; pfam01361 710696002994 active site 1 [active] 710696002995 dimer interface [polypeptide binding]; other site 710696002996 hexamer interface [polypeptide binding]; other site 710696002997 active site 2 [active] 710696002998 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 710696002999 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 710696003000 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 710696003001 active site 710696003002 catalytic residues [active] 710696003003 metal binding site [ion binding]; metal-binding site 710696003004 DmpG-like communication domain; Region: DmpG_comm; pfam07836 710696003005 acetaldehyde dehydrogenase; Validated; Region: PRK08300 710696003006 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 710696003007 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 710696003008 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 710696003009 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710696003010 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 710696003011 Bacterial transcriptional regulator; Region: IclR; pfam01614 710696003012 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 710696003013 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710696003014 Bacterial transcriptional regulator; Region: IclR; pfam01614 710696003015 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 710696003016 NMT1/THI5 like; Region: NMT1; pfam09084 710696003017 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 710696003018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696003019 dimer interface [polypeptide binding]; other site 710696003020 conserved gate region; other site 710696003021 putative PBP binding loops; other site 710696003022 ABC-ATPase subunit interface; other site 710696003023 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 710696003024 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 710696003025 Walker A/P-loop; other site 710696003026 ATP binding site [chemical binding]; other site 710696003027 Q-loop/lid; other site 710696003028 ABC transporter signature motif; other site 710696003029 Walker B; other site 710696003030 D-loop; other site 710696003031 H-loop/switch region; other site 710696003032 Domain of unknown function (DUF336); Region: DUF336; pfam03928 710696003033 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 710696003034 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710696003035 active site 710696003036 metal binding site [ion binding]; metal-binding site 710696003037 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710696003038 active site 710696003039 metal binding site [ion binding]; metal-binding site 710696003040 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 710696003041 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710696003042 catalytic loop [active] 710696003043 iron binding site [ion binding]; other site 710696003044 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710696003045 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710696003046 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696003047 Q-loop/lid; other site 710696003048 ABC transporter signature motif; other site 710696003049 Walker B; other site 710696003050 D-loop; other site 710696003051 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710696003052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696003053 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 710696003054 Walker A/P-loop; other site 710696003055 ATP binding site [chemical binding]; other site 710696003056 Q-loop/lid; other site 710696003057 ABC transporter signature motif; other site 710696003058 Walker B; other site 710696003059 D-loop; other site 710696003060 H-loop/switch region; other site 710696003061 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 710696003062 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710696003063 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 710696003064 ABC1 family; Region: ABC1; cl17513 710696003065 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 710696003066 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 710696003067 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 710696003068 homodimer interface [polypeptide binding]; other site 710696003069 NADP binding site [chemical binding]; other site 710696003070 substrate binding site [chemical binding]; other site 710696003071 Spore germination protein [General function prediction only]; Region: COG5401 710696003072 Sporulation and spore germination; Region: Germane; pfam10646 710696003073 HAMP domain; Region: HAMP; pfam00672 710696003074 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710696003075 dimerization interface [polypeptide binding]; other site 710696003076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710696003077 dimer interface [polypeptide binding]; other site 710696003078 phosphorylation site [posttranslational modification] 710696003079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696003080 ATP binding site [chemical binding]; other site 710696003081 Mg2+ binding site [ion binding]; other site 710696003082 G-X-G motif; other site 710696003083 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710696003084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696003085 active site 710696003086 phosphorylation site [posttranslational modification] 710696003087 intermolecular recognition site; other site 710696003088 dimerization interface [polypeptide binding]; other site 710696003089 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710696003090 DNA binding site [nucleotide binding] 710696003091 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710696003092 anti sigma factor interaction site; other site 710696003093 regulatory phosphorylation site [posttranslational modification]; other site 710696003094 malate dehydrogenase; Provisional; Region: PRK05442 710696003095 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 710696003096 NAD(P) binding site [chemical binding]; other site 710696003097 dimer interface [polypeptide binding]; other site 710696003098 malate binding site [chemical binding]; other site 710696003099 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 710696003100 active site 710696003101 intersubunit interface [polypeptide binding]; other site 710696003102 zinc binding site [ion binding]; other site 710696003103 Na+ binding site [ion binding]; other site 710696003104 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710696003105 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710696003106 DNA-binding site [nucleotide binding]; DNA binding site 710696003107 FCD domain; Region: FCD; pfam07729 710696003108 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 710696003109 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 710696003110 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710696003111 fructuronate transporter; Provisional; Region: PRK10034; cl15264 710696003112 GntP family permease; Region: GntP_permease; pfam02447 710696003113 CHAT domain; Region: CHAT; cl17868 710696003114 Domain of unknown function DUF11; Region: DUF11; pfam01345 710696003115 conserved repeat domain; Region: B_ant_repeat; TIGR01451 710696003116 Domain of unknown function DUF11; Region: DUF11; pfam01345 710696003117 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710696003118 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 710696003119 Protein of unknown function (DUF419); Region: DUF419; cl15265 710696003120 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 710696003121 amphipathic channel; other site 710696003122 Asn-Pro-Ala signature motifs; other site 710696003123 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 710696003124 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 710696003125 active site 710696003126 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 710696003127 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 710696003128 Probable Catalytic site; other site 710696003129 metal-binding site 710696003130 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 710696003131 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 710696003132 active site 710696003133 oxyanion hole [active] 710696003134 catalytic triad [active] 710696003135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 710696003136 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 710696003137 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 710696003138 active site 710696003139 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 710696003140 GDP-Fucose binding site [chemical binding]; other site 710696003141 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 710696003142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696003143 Walker A motif; other site 710696003144 ATP binding site [chemical binding]; other site 710696003145 Walker B motif; other site 710696003146 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 710696003147 Integrase core domain; Region: rve; pfam00665 710696003148 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696003149 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710696003150 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 710696003151 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 710696003152 active site 710696003153 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 710696003154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 710696003155 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 710696003156 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710696003157 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 710696003158 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 710696003159 Transposase; Region: DDE_Tnp_ISL3; pfam01610 710696003160 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 710696003161 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 710696003162 Walker A/P-loop; other site 710696003163 ATP binding site [chemical binding]; other site 710696003164 Q-loop/lid; other site 710696003165 ABC transporter signature motif; other site 710696003166 Walker B; other site 710696003167 D-loop; other site 710696003168 H-loop/switch region; other site 710696003169 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 710696003170 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 710696003171 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 710696003172 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 710696003173 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696003174 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 710696003175 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710696003176 Proline dehydrogenase; Region: Pro_dh; cl03282 710696003177 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 710696003178 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 710696003179 Glutamate binding site [chemical binding]; other site 710696003180 NAD binding site [chemical binding]; other site 710696003181 catalytic residues [active] 710696003182 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 710696003183 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 710696003184 Active Sites [active] 710696003185 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 710696003186 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 710696003187 putative GEF interaction site [polypeptide binding]; other site 710696003188 G1 box; other site 710696003189 GTP/Mg2+ binding site [chemical binding]; other site 710696003190 Switch I region; other site 710696003191 G2 box; other site 710696003192 CysD dimerization site [polypeptide binding]; other site 710696003193 G3 box; other site 710696003194 Switch II region; other site 710696003195 G4 box; other site 710696003196 G5 box; other site 710696003197 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 710696003198 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 710696003199 CHAT domain; Region: CHAT; cl17868 710696003200 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710696003201 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710696003202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710696003203 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 710696003204 dimerization interface [polypeptide binding]; other site 710696003205 substrate binding pocket [chemical binding]; other site 710696003206 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 710696003207 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 710696003208 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710696003209 substrate binding site [chemical binding]; other site 710696003210 ATP binding site [chemical binding]; other site 710696003211 Uncharacterized conserved protein [Function unknown]; Region: COG0398 710696003212 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 710696003213 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 710696003214 NADP binding site [chemical binding]; other site 710696003215 active site 710696003216 putative substrate binding site [chemical binding]; other site 710696003217 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 710696003218 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 710696003219 NAD binding site [chemical binding]; other site 710696003220 substrate binding site [chemical binding]; other site 710696003221 homodimer interface [polypeptide binding]; other site 710696003222 active site 710696003223 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 710696003224 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 710696003225 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 710696003226 active site 710696003227 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 710696003228 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 710696003229 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 710696003230 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 710696003231 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 710696003232 substrate binding site; other site 710696003233 tetramer interface; other site 710696003234 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 710696003235 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 710696003236 Low molecular weight phosphatase family; Region: LMWPc; cl00105 710696003237 active site 710696003238 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 710696003239 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 710696003240 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696003241 putative ADP-binding pocket [chemical binding]; other site 710696003242 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 710696003243 PqqD family protein, HPr-rel-A system; Region: PqqD_rel_X; TIGR04353 710696003244 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 710696003245 Chain length determinant protein; Region: Wzz; cl15801 710696003246 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 710696003247 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710696003248 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710696003249 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696003250 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 710696003251 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 710696003252 Probable Catalytic site; other site 710696003253 metal-binding site 710696003254 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 710696003255 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696003256 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710696003257 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710696003258 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696003259 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 710696003260 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 710696003261 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 710696003262 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696003263 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696003264 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710696003265 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 710696003266 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696003267 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 710696003268 putative catalytic site [active] 710696003269 putative metal binding site [ion binding]; other site 710696003270 putative phosphate binding site [ion binding]; other site 710696003271 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 710696003272 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 710696003273 active site 710696003274 HIGH motif; other site 710696003275 dimer interface [polypeptide binding]; other site 710696003276 KMSKS motif; other site 710696003277 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 710696003278 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 710696003279 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 710696003280 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 710696003281 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 710696003282 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 710696003283 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 710696003284 L-aspartate oxidase; Provisional; Region: PRK06175 710696003285 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 710696003286 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 710696003287 putative Iron-sulfur protein interface [polypeptide binding]; other site 710696003288 proximal heme binding site [chemical binding]; other site 710696003289 distal heme binding site [chemical binding]; other site 710696003290 putative dimer interface [polypeptide binding]; other site 710696003291 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696003292 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 710696003293 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 710696003294 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 710696003295 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 710696003296 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 710696003297 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 710696003298 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 710696003299 Substrate binding site; other site 710696003300 Cupin domain; Region: Cupin_2; cl17218 710696003301 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 710696003302 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 710696003303 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710696003304 Walker A/P-loop; other site 710696003305 ATP binding site [chemical binding]; other site 710696003306 Q-loop/lid; other site 710696003307 ABC transporter signature motif; other site 710696003308 Walker B; other site 710696003309 D-loop; other site 710696003310 H-loop/switch region; other site 710696003311 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 710696003312 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 710696003313 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 710696003314 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 710696003315 metal binding site [ion binding]; metal-binding site 710696003316 putative dimer interface [polypeptide binding]; other site 710696003317 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 710696003318 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 710696003319 ligand binding site [chemical binding]; other site 710696003320 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 710696003321 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 710696003322 Walker A/P-loop; other site 710696003323 ATP binding site [chemical binding]; other site 710696003324 Q-loop/lid; other site 710696003325 ABC transporter signature motif; other site 710696003326 Walker B; other site 710696003327 D-loop; other site 710696003328 H-loop/switch region; other site 710696003329 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 710696003330 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 710696003331 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710696003332 TM-ABC transporter signature motif; other site 710696003333 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710696003334 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 710696003335 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 710696003336 TM-ABC transporter signature motif; other site 710696003337 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 710696003338 active site 710696003339 catalytic motif [active] 710696003340 Zn binding site [ion binding]; other site 710696003341 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 710696003342 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 710696003343 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 710696003344 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 710696003345 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 710696003346 adenosine deaminase; Provisional; Region: PRK09358 710696003347 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 710696003348 active site 710696003349 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 710696003350 AAA domain; Region: AAA_17; pfam13207 710696003351 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710696003352 NAD(P) binding site [chemical binding]; other site 710696003353 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 710696003354 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710696003355 NAD(P) binding site [chemical binding]; other site 710696003356 catalytic residues [active] 710696003357 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 710696003358 intersubunit interface [polypeptide binding]; other site 710696003359 active site 710696003360 catalytic residue [active] 710696003361 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 710696003362 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 710696003363 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 710696003364 active site 710696003365 substrate binding site [chemical binding]; other site 710696003366 metal binding site [ion binding]; metal-binding site 710696003367 purine nucleoside phosphorylase; Provisional; Region: PRK08202 710696003368 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 710696003369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710696003370 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710696003371 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710696003372 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 710696003373 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 710696003374 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710696003375 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 710696003376 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 710696003377 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710696003378 carboxyltransferase (CT) interaction site; other site 710696003379 biotinylation site [posttranslational modification]; other site 710696003380 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710696003381 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710696003382 active site 710696003383 catalytic tetrad [active] 710696003384 Domain of unknown function (DUF3806); Region: DUF3806; pfam12713 710696003385 Fe-S metabolism associated domain; Region: SufE; cl00951 710696003386 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 710696003387 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 710696003388 active site residue [active] 710696003389 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 710696003390 active site residue [active] 710696003391 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 710696003392 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 710696003393 DNA binding residues [nucleotide binding] 710696003394 putative dimer interface [polypeptide binding]; other site 710696003395 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710696003396 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710696003397 active site 710696003398 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710696003399 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710696003400 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710696003401 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 710696003402 active site 710696003403 dimer interface [polypeptide binding]; other site 710696003404 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 710696003405 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710696003406 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710696003407 active site 710696003408 ATP binding site [chemical binding]; other site 710696003409 substrate binding site [chemical binding]; other site 710696003410 activation loop (A-loop); other site 710696003411 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710696003412 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 710696003413 FeoC like transcriptional regulator; Region: FeoC; cl17677 710696003414 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 710696003415 G1 box; other site 710696003416 GTP/Mg2+ binding site [chemical binding]; other site 710696003417 G2 box; other site 710696003418 Switch I region; other site 710696003419 G3 box; other site 710696003420 Switch II region; other site 710696003421 G4 box; other site 710696003422 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 710696003423 Nucleoside recognition; Region: Gate; pfam07670 710696003424 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 710696003425 FeoA domain; Region: FeoA; cl00838 710696003426 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710696003427 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 710696003428 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710696003429 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 710696003430 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 710696003431 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 710696003432 cyclase homology domain; Region: CHD; cd07302 710696003433 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710696003434 nucleotidyl binding site; other site 710696003435 metal binding site [ion binding]; metal-binding site 710696003436 dimer interface [polypeptide binding]; other site 710696003437 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710696003438 enoyl-CoA hydratase; Region: PLN02600 710696003439 substrate binding site [chemical binding]; other site 710696003440 oxyanion hole (OAH) forming residues; other site 710696003441 trimer interface [polypeptide binding]; other site 710696003442 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710696003443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696003444 active site 710696003445 phosphorylation site [posttranslational modification] 710696003446 intermolecular recognition site; other site 710696003447 dimerization interface [polypeptide binding]; other site 710696003448 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710696003449 DNA binding site [nucleotide binding] 710696003450 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710696003451 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710696003452 dimer interface [polypeptide binding]; other site 710696003453 phosphorylation site [posttranslational modification] 710696003454 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696003455 ATP binding site [chemical binding]; other site 710696003456 Mg2+ binding site [ion binding]; other site 710696003457 G-X-G motif; other site 710696003458 Predicted membrane protein [Function unknown]; Region: COG2246 710696003459 GtrA-like protein; Region: GtrA; pfam04138 710696003460 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 710696003461 ATP-grasp domain; Region: ATP-grasp; pfam02222 710696003462 AIR carboxylase; Region: AIRC; pfam00731 710696003463 CoA binding domain; Region: CoA_binding_2; pfam13380 710696003464 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710696003465 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710696003466 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 710696003467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696003468 NAD(P) binding site [chemical binding]; other site 710696003469 active site 710696003470 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 710696003471 ligand binding site; other site 710696003472 tetramer interface; other site 710696003473 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710696003474 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 710696003475 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 710696003476 putative trimer interface [polypeptide binding]; other site 710696003477 putative CoA binding site [chemical binding]; other site 710696003478 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 710696003479 NeuB family; Region: NeuB; pfam03102 710696003480 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 710696003481 NeuB binding interface [polypeptide binding]; other site 710696003482 putative substrate binding site [chemical binding]; other site 710696003483 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 710696003484 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710696003485 FOG: CBS domain [General function prediction only]; Region: COG0517 710696003486 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 710696003487 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 710696003488 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 710696003489 Substrate binding site; other site 710696003490 metal-binding site 710696003491 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 710696003492 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 710696003493 NAD binding site [chemical binding]; other site 710696003494 substrate binding site [chemical binding]; other site 710696003495 active site 710696003496 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 710696003497 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 710696003498 inhibitor-cofactor binding pocket; inhibition site 710696003499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696003500 catalytic residue [active] 710696003501 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 710696003502 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710696003503 catalytic residue [active] 710696003504 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 710696003505 putative dimer interface [polypeptide binding]; other site 710696003506 catalytic triad [active] 710696003507 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 710696003508 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 710696003509 homodimer interface [polypeptide binding]; other site 710696003510 substrate-cofactor binding pocket; other site 710696003511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696003512 catalytic residue [active] 710696003513 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710696003514 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710696003515 active site 710696003516 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 710696003517 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 710696003518 Ligand binding site; other site 710696003519 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 710696003520 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 710696003521 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 710696003522 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 710696003523 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 710696003524 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 710696003525 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 710696003526 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 710696003527 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 710696003528 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 710696003529 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 710696003530 TIGR03089 family protein; Region: TIGR03089 710696003531 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 710696003532 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 710696003533 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 710696003534 Ligand binding site; other site 710696003535 Putative Catalytic site; other site 710696003536 DXD motif; other site 710696003537 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710696003538 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696003539 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 710696003540 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710696003541 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 710696003542 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 710696003543 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 710696003544 minor groove reading motif; other site 710696003545 helix-hairpin-helix signature motif; other site 710696003546 active site 710696003547 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710696003548 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710696003549 phosphopeptide binding site; other site 710696003550 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710696003551 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 710696003552 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 710696003553 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 710696003554 ATP binding site [chemical binding]; other site 710696003555 Walker A motif; other site 710696003556 hexamer interface [polypeptide binding]; other site 710696003557 Walker B motif; other site 710696003558 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 710696003559 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 710696003560 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 710696003561 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 710696003562 peptide chain release factor 2; Validated; Region: prfB; PRK00578 710696003563 PCRF domain; Region: PCRF; pfam03462 710696003564 RF-1 domain; Region: RF-1; pfam00472 710696003565 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 710696003566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696003567 Walker A/P-loop; other site 710696003568 ATP binding site [chemical binding]; other site 710696003569 Q-loop/lid; other site 710696003570 ABC transporter signature motif; other site 710696003571 Walker B; other site 710696003572 D-loop; other site 710696003573 H-loop/switch region; other site 710696003574 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 710696003575 FtsX-like permease family; Region: FtsX; pfam02687 710696003576 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 710696003577 Peptidase family M23; Region: Peptidase_M23; pfam01551 710696003578 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 710696003579 SmpB-tmRNA interface; other site 710696003580 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 710696003581 pyruvate carboxylase; Reviewed; Region: PRK12999 710696003582 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710696003583 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710696003584 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 710696003585 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 710696003586 active site 710696003587 catalytic residues [active] 710696003588 metal binding site [ion binding]; metal-binding site 710696003589 homodimer binding site [polypeptide binding]; other site 710696003590 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710696003591 carboxyltransferase (CT) interaction site; other site 710696003592 biotinylation site [posttranslational modification]; other site 710696003593 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710696003594 catalytic residues [active] 710696003595 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 710696003596 helicase 45; Provisional; Region: PTZ00424 710696003597 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 710696003598 ATP binding site [chemical binding]; other site 710696003599 Mg++ binding site [ion binding]; other site 710696003600 motif III; other site 710696003601 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710696003602 nucleotide binding region [chemical binding]; other site 710696003603 ATP-binding site [chemical binding]; other site 710696003604 hypothetical protein; Validated; Region: PRK00228 710696003605 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 710696003606 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 710696003607 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 710696003608 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710696003609 ATP binding site [chemical binding]; other site 710696003610 putative Mg++ binding site [ion binding]; other site 710696003611 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 710696003612 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 710696003613 active site 710696003614 metal binding site [ion binding]; metal-binding site 710696003615 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 710696003616 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 710696003617 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 710696003618 AsnC family; Region: AsnC_trans_reg; pfam01037 710696003619 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 710696003620 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 710696003621 dimer interface [polypeptide binding]; other site 710696003622 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 710696003623 active site 710696003624 Fe binding site [ion binding]; other site 710696003625 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 710696003626 RDD family; Region: RDD; pfam06271 710696003627 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710696003628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696003629 putative substrate translocation pore; other site 710696003630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696003631 fumarylacetoacetase; Region: PLN02856 710696003632 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 710696003633 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 710696003634 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 710696003635 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 710696003636 Isochorismatase family; Region: Isochorismatase; pfam00857 710696003637 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 710696003638 catalytic triad [active] 710696003639 conserved cis-peptide bond; other site 710696003640 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 710696003641 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 710696003642 active site 710696003643 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 710696003644 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 710696003645 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 710696003646 ribonuclease PH; Reviewed; Region: rph; PRK00173 710696003647 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 710696003648 oligomer interface [polypeptide binding]; other site 710696003649 RNA binding site [nucleotide binding]; other site 710696003650 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 710696003651 active site 710696003652 dimerization interface [polypeptide binding]; other site 710696003653 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 710696003654 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 710696003655 Moco binding site; other site 710696003656 metal coordination site [ion binding]; other site 710696003657 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 710696003658 homotrimer interaction site [polypeptide binding]; other site 710696003659 putative active site [active] 710696003660 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 710696003661 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 710696003662 catalytic triad [active] 710696003663 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 710696003664 oligomerisation interface [polypeptide binding]; other site 710696003665 mobile loop; other site 710696003666 roof hairpin; other site 710696003667 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 710696003668 catalytic site [active] 710696003669 putative active site [active] 710696003670 putative substrate binding site [chemical binding]; other site 710696003671 dimer interface [polypeptide binding]; other site 710696003672 Protease prsW family; Region: PrsW-protease; pfam13367 710696003673 Dynamin family; Region: Dynamin_N; pfam00350 710696003674 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 710696003675 G1 box; other site 710696003676 GTP/Mg2+ binding site [chemical binding]; other site 710696003677 G2 box; other site 710696003678 Switch I region; other site 710696003679 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 710696003680 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 710696003681 G1 box; other site 710696003682 G1 box; other site 710696003683 GTP/Mg2+ binding site [chemical binding]; other site 710696003684 GTP/Mg2+ binding site [chemical binding]; other site 710696003685 G2 box; other site 710696003686 Switch I region; other site 710696003687 G3 box; other site 710696003688 Switch II region; other site 710696003689 G4 box; other site 710696003690 G5 box; other site 710696003691 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 710696003692 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 710696003693 dimer interface [polypeptide binding]; other site 710696003694 ssDNA binding site [nucleotide binding]; other site 710696003695 tetramer (dimer of dimers) interface [polypeptide binding]; other site 710696003696 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 710696003697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696003698 Walker A/P-loop; other site 710696003699 ATP binding site [chemical binding]; other site 710696003700 Q-loop/lid; other site 710696003701 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710696003702 ABC transporter; Region: ABC_tran_2; pfam12848 710696003703 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710696003704 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710696003705 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710696003706 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 710696003707 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 710696003708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710696003709 DNA-binding site [nucleotide binding]; DNA binding site 710696003710 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710696003711 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696003712 homodimer interface [polypeptide binding]; other site 710696003713 catalytic residue [active] 710696003714 Predicted membrane protein [Function unknown]; Region: COG2364 710696003715 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 710696003716 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710696003717 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710696003718 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 710696003719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710696003720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696003721 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710696003722 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710696003723 active site 710696003724 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710696003725 classical (c) SDRs; Region: SDR_c; cd05233 710696003726 NAD(P) binding site [chemical binding]; other site 710696003727 active site 710696003728 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 710696003729 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 710696003730 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 710696003731 active site 710696003732 catalytic site [active] 710696003733 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 710696003734 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 710696003735 active site 710696003736 catalytic site [active] 710696003737 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 710696003738 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 710696003739 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 710696003740 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 710696003741 catalytic site [active] 710696003742 active site 710696003743 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 710696003744 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 710696003745 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710696003746 active site 710696003747 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710696003748 catalytic triad [active] 710696003749 dimer interface [polypeptide binding]; other site 710696003750 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 710696003751 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710696003752 ATP binding site [chemical binding]; other site 710696003753 putative Mg++ binding site [ion binding]; other site 710696003754 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710696003755 nucleotide binding region [chemical binding]; other site 710696003756 ATP-binding site [chemical binding]; other site 710696003757 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 710696003758 active site 710696003759 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 710696003760 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 710696003761 putative active site [active] 710696003762 catalytic site [active] 710696003763 putative metal binding site [ion binding]; other site 710696003764 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 710696003765 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 710696003766 active site 710696003767 catalytic site [active] 710696003768 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 710696003769 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 710696003770 apolar tunnel; other site 710696003771 heme binding site [chemical binding]; other site 710696003772 dimerization interface [polypeptide binding]; other site 710696003773 Mechanosensitive ion channel; Region: MS_channel; pfam00924 710696003774 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 710696003775 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 710696003776 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 710696003777 Zn binding site [ion binding]; other site 710696003778 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 710696003779 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710696003780 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 710696003781 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710696003782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696003783 S-adenosylmethionine binding site [chemical binding]; other site 710696003784 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 710696003785 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 710696003786 tetramer interface [polypeptide binding]; other site 710696003787 TPP-binding site [chemical binding]; other site 710696003788 heterodimer interface [polypeptide binding]; other site 710696003789 phosphorylation loop region [posttranslational modification] 710696003790 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 710696003791 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 710696003792 alpha subunit interface [polypeptide binding]; other site 710696003793 TPP binding site [chemical binding]; other site 710696003794 heterodimer interface [polypeptide binding]; other site 710696003795 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710696003796 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 710696003797 lipoyl-biotinyl attachment site [posttranslational modification]; other site 710696003798 trigger factor; Provisional; Region: tig; PRK01490 710696003799 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 710696003800 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 710696003801 Clp protease; Region: CLP_protease; pfam00574 710696003802 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 710696003803 oligomer interface [polypeptide binding]; other site 710696003804 active site residues [active] 710696003805 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 710696003806 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 710696003807 oligomer interface [polypeptide binding]; other site 710696003808 active site residues [active] 710696003809 Acyl CoA binding protein; Region: ACBP; pfam00887 710696003810 acyl-CoA binding pocket [chemical binding]; other site 710696003811 CoA binding site [chemical binding]; other site 710696003812 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 710696003813 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 710696003814 putative active site [active] 710696003815 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 710696003816 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 710696003817 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 710696003818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696003819 Walker A motif; other site 710696003820 ATP binding site [chemical binding]; other site 710696003821 Walker B motif; other site 710696003822 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 710696003823 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 710696003824 Protein of unknown function DUF58; Region: DUF58; pfam01882 710696003825 MoxR-like ATPases [General function prediction only]; Region: COG0714 710696003826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696003827 ATP binding site [chemical binding]; other site 710696003828 Walker A motif; other site 710696003829 Walker B motif; other site 710696003830 arginine finger; other site 710696003831 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 710696003832 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 710696003833 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710696003834 active site 710696003835 HIGH motif; other site 710696003836 nucleotide binding site [chemical binding]; other site 710696003837 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710696003838 active site 710696003839 KMSKS motif; other site 710696003840 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 710696003841 tRNA binding surface [nucleotide binding]; other site 710696003842 anticodon binding site; other site 710696003843 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710696003844 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710696003845 putative acyl-acceptor binding pocket; other site 710696003846 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 710696003847 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 710696003848 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 710696003849 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 710696003850 homodimer interface [polypeptide binding]; other site 710696003851 oligonucleotide binding site [chemical binding]; other site 710696003852 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 710696003853 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 710696003854 GTPase CgtA; Reviewed; Region: obgE; PRK12296 710696003855 GTP1/OBG; Region: GTP1_OBG; pfam01018 710696003856 Obg GTPase; Region: Obg; cd01898 710696003857 G1 box; other site 710696003858 GTP/Mg2+ binding site [chemical binding]; other site 710696003859 Switch I region; other site 710696003860 G2 box; other site 710696003861 G3 box; other site 710696003862 Switch II region; other site 710696003863 G4 box; other site 710696003864 G5 box; other site 710696003865 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 710696003866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 710696003867 Histidine kinase; Region: His_kinase; pfam06580 710696003868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696003869 ATP binding site [chemical binding]; other site 710696003870 Mg2+ binding site [ion binding]; other site 710696003871 G-X-G motif; other site 710696003872 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 710696003873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696003874 active site 710696003875 phosphorylation site [posttranslational modification] 710696003876 intermolecular recognition site; other site 710696003877 dimerization interface [polypeptide binding]; other site 710696003878 LytTr DNA-binding domain; Region: LytTR; smart00850 710696003879 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 710696003880 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 710696003881 Na binding site [ion binding]; other site 710696003882 Protein of unknown function, DUF485; Region: DUF485; pfam04341 710696003883 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 710696003884 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 710696003885 Na binding site [ion binding]; other site 710696003886 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047 710696003887 gamma-glutamyl kinase; Provisional; Region: PRK05429 710696003888 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 710696003889 nucleotide binding site [chemical binding]; other site 710696003890 homotetrameric interface [polypeptide binding]; other site 710696003891 putative phosphate binding site [ion binding]; other site 710696003892 putative allosteric binding site; other site 710696003893 PUA domain; Region: PUA; pfam01472 710696003894 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 710696003895 ThiC-associated domain; Region: ThiC-associated; pfam13667 710696003896 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 710696003897 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 710696003898 dimer interface [polypeptide binding]; other site 710696003899 substrate binding site [chemical binding]; other site 710696003900 ATP binding site [chemical binding]; other site 710696003901 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 710696003902 thiamine phosphate binding site [chemical binding]; other site 710696003903 active site 710696003904 pyrophosphate binding site [ion binding]; other site 710696003905 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 710696003906 ThiS interaction site; other site 710696003907 putative active site [active] 710696003908 tetramer interface [polypeptide binding]; other site 710696003909 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 710696003910 thiS-thiF/thiG interaction site; other site 710696003911 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 710696003912 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 710696003913 thiamine phosphate binding site [chemical binding]; other site 710696003914 active site 710696003915 pyrophosphate binding site [ion binding]; other site 710696003916 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 710696003917 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 710696003918 putative catalytic cysteine [active] 710696003919 Methyltransferase domain; Region: Methyltransf_23; pfam13489 710696003920 Methyltransferase domain; Region: Methyltransf_11; pfam08241 710696003921 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 710696003922 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 710696003923 Ligand binding site; other site 710696003924 Putative Catalytic site; other site 710696003925 DXD motif; other site 710696003926 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 710696003927 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 710696003928 active site 710696003929 (T/H)XGH motif; other site 710696003930 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 710696003931 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710696003932 catalytic core [active] 710696003933 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710696003934 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710696003935 active site 710696003936 CoA binding site [chemical binding]; other site 710696003937 AMP binding site [chemical binding]; other site 710696003938 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710696003939 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 710696003940 dimer interface [polypeptide binding]; other site 710696003941 active site 710696003942 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710696003943 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 710696003944 Walker A/P-loop; other site 710696003945 ATP binding site [chemical binding]; other site 710696003946 Q-loop/lid; other site 710696003947 ABC transporter signature motif; other site 710696003948 Walker B; other site 710696003949 D-loop; other site 710696003950 H-loop/switch region; other site 710696003951 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 710696003952 BioY family; Region: BioY; pfam02632 710696003953 Caspase domain; Region: Peptidase_C14; pfam00656 710696003954 CHAT domain; Region: CHAT; pfam12770 710696003955 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 710696003956 putative ligand binding site [chemical binding]; other site 710696003957 Predicted thioesterase [General function prediction only]; Region: COG5496 710696003958 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 710696003959 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710696003960 active site 710696003961 HIGH motif; other site 710696003962 nucleotide binding site [chemical binding]; other site 710696003963 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710696003964 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 710696003965 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710696003966 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710696003967 active site 710696003968 KMSKS motif; other site 710696003969 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 710696003970 tRNA binding surface [nucleotide binding]; other site 710696003971 EDD domain protein, DegV family; Region: DegV; TIGR00762 710696003972 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 710696003973 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 710696003974 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 710696003975 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 710696003976 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 710696003977 putative active site [active] 710696003978 putative substrate binding site [chemical binding]; other site 710696003979 putative cosubstrate binding site; other site 710696003980 catalytic site [active] 710696003981 comEA protein; Region: comE; TIGR01259 710696003982 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 710696003983 Competence protein; Region: Competence; pfam03772 710696003984 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710696003985 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 710696003986 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 710696003987 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 710696003988 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 710696003989 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710696003990 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710696003991 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 710696003992 putative dimerization interface [polypeptide binding]; other site 710696003993 NAD-dependent deacetylase; Provisional; Region: PRK00481 710696003994 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 710696003995 putative transposase OrfB; Reviewed; Region: PHA02517 710696003996 HTH-like domain; Region: HTH_21; pfam13276 710696003997 Integrase core domain; Region: rve; pfam00665 710696003998 Integrase core domain; Region: rve_3; pfam13683 710696003999 LexA repressor; Validated; Region: PRK00215 710696004000 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 710696004001 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 710696004002 Catalytic site [active] 710696004003 LysM domain; Region: LysM; pfam01476 710696004004 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 710696004005 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 710696004006 ATP cone domain; Region: ATP-cone; pfam03477 710696004007 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 710696004008 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 710696004009 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 710696004010 active site 710696004011 dimer interface [polypeptide binding]; other site 710696004012 effector binding site; other site 710696004013 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 710696004014 TSCPD domain; Region: TSCPD; pfam12637 710696004015 HNH endonuclease; Region: HNH_2; pfam13391 710696004016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 710696004017 HipA N-terminal domain; Region: Couple_hipA; pfam13657 710696004018 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 710696004019 HipA-like N-terminal domain; Region: HipA_N; pfam07805 710696004020 HipA-like C-terminal domain; Region: HipA_C; pfam07804 710696004021 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 710696004022 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710696004023 classical (c) SDRs; Region: SDR_c; cd05233 710696004024 NAD(P) binding site [chemical binding]; other site 710696004025 active site 710696004026 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 710696004027 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 710696004028 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 710696004029 TIGR02680 family protein; Region: TIGR02680 710696004030 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 710696004031 TIGR02679 family protein; Region: TIGR02679 710696004032 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 710696004033 ChaB; Region: ChaB; pfam06150 710696004034 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 710696004035 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710696004036 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710696004037 active site 710696004038 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710696004039 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710696004040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696004041 NAD(P) binding site [chemical binding]; other site 710696004042 active site 710696004043 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 710696004044 AAA ATPase domain; Region: AAA_16; pfam13191 710696004045 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710696004046 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710696004047 DNA binding residues [nucleotide binding] 710696004048 dimerization interface [polypeptide binding]; other site 710696004049 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710696004050 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710696004051 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710696004052 DNA binding residues [nucleotide binding] 710696004053 dimerization interface [polypeptide binding]; other site 710696004054 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 710696004055 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 710696004056 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 710696004057 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710696004058 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710696004059 active site 710696004060 catalytic tetrad [active] 710696004061 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710696004062 Ligand Binding Site [chemical binding]; other site 710696004063 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710696004064 Ligand Binding Site [chemical binding]; other site 710696004065 Family description; Region: UvrD_C_2; pfam13538 710696004066 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710696004067 Ligand Binding Site [chemical binding]; other site 710696004068 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 710696004069 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710696004070 hydrophobic ligand binding site; other site 710696004071 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 710696004072 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 710696004073 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 710696004074 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 710696004075 RNA binding site [nucleotide binding]; other site 710696004076 amidase; Provisional; Region: PRK07042 710696004077 Amidase; Region: Amidase; cl11426 710696004078 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 710696004079 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 710696004080 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 710696004081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696004082 dimer interface [polypeptide binding]; other site 710696004083 conserved gate region; other site 710696004084 putative PBP binding loops; other site 710696004085 ABC-ATPase subunit interface; other site 710696004086 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 710696004087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696004088 putative PBP binding loops; other site 710696004089 dimer interface [polypeptide binding]; other site 710696004090 ABC-ATPase subunit interface; other site 710696004091 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 710696004092 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710696004093 Walker A/P-loop; other site 710696004094 ATP binding site [chemical binding]; other site 710696004095 Q-loop/lid; other site 710696004096 ABC transporter signature motif; other site 710696004097 Walker B; other site 710696004098 D-loop; other site 710696004099 H-loop/switch region; other site 710696004100 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710696004101 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 710696004102 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710696004103 Walker A/P-loop; other site 710696004104 ATP binding site [chemical binding]; other site 710696004105 Q-loop/lid; other site 710696004106 ABC transporter signature motif; other site 710696004107 Walker B; other site 710696004108 D-loop; other site 710696004109 H-loop/switch region; other site 710696004110 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710696004111 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710696004112 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710696004113 NAD(P) binding site [chemical binding]; other site 710696004114 catalytic residues [active] 710696004115 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710696004116 classical (c) SDRs; Region: SDR_c; cd05233 710696004117 NAD(P) binding site [chemical binding]; other site 710696004118 active site 710696004119 guanine deaminase; Provisional; Region: PRK09228 710696004120 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710696004121 active site 710696004122 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 710696004123 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 710696004124 XdhC Rossmann domain; Region: XdhC_C; pfam13478 710696004125 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 710696004126 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 710696004127 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 710696004128 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 710696004129 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 710696004130 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 710696004131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696004132 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710696004133 Walker A motif; other site 710696004134 ATP binding site [chemical binding]; other site 710696004135 Walker B motif; other site 710696004136 arginine finger; other site 710696004137 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 710696004138 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 710696004139 RNase_H superfamily; Region: RNase_H_2; pfam13482 710696004140 AAA domain; Region: AAA_30; pfam13604 710696004141 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 710696004142 AAA domain; Region: AAA_12; pfam13087 710696004143 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 710696004144 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 710696004145 active site 710696004146 catalytic residues [active] 710696004147 FemAB family; Region: FemAB; pfam02388 710696004148 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 710696004149 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 710696004150 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710696004151 ATP binding site [chemical binding]; other site 710696004152 putative Mg++ binding site [ion binding]; other site 710696004153 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710696004154 nucleotide binding region [chemical binding]; other site 710696004155 ATP-binding site [chemical binding]; other site 710696004156 Helicase associated domain (HA2); Region: HA2; pfam04408 710696004157 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 710696004158 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 710696004159 PAC2 family; Region: PAC2; pfam09754 710696004160 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 710696004161 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 710696004162 active site 710696004163 DNA binding site [nucleotide binding] 710696004164 catalytic site [active] 710696004165 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 710696004166 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710696004167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696004168 homodimer interface [polypeptide binding]; other site 710696004169 catalytic residue [active] 710696004170 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 710696004171 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 710696004172 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 710696004173 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710696004174 Ligand Binding Site [chemical binding]; other site 710696004175 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 710696004176 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 710696004177 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696004178 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 710696004179 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710696004180 DNA binding residues [nucleotide binding] 710696004181 Low molecular weight phosphatase family; Region: LMWPc; cl00105 710696004182 active site 710696004183 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 710696004184 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 710696004185 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 710696004186 Protein of unknown function DUF58; Region: DUF58; pfam01882 710696004187 MoxR-like ATPases [General function prediction only]; Region: COG0714 710696004188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696004189 Walker A motif; other site 710696004190 ATP binding site [chemical binding]; other site 710696004191 Walker B motif; other site 710696004192 arginine finger; other site 710696004193 cell division protein MraZ; Reviewed; Region: PRK00326 710696004194 MraZ protein; Region: MraZ; pfam02381 710696004195 MraZ protein; Region: MraZ; pfam02381 710696004196 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 710696004197 MraW methylase family; Region: Methyltransf_5; cl17771 710696004198 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 710696004199 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 710696004200 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710696004201 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 710696004202 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 710696004203 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710696004204 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 710696004205 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 710696004206 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 710696004207 Mg++ binding site [ion binding]; other site 710696004208 putative catalytic motif [active] 710696004209 putative substrate binding site [chemical binding]; other site 710696004210 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 710696004211 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710696004212 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710696004213 cell division protein FtsW; Region: ftsW; TIGR02614 710696004214 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 710696004215 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 710696004216 active site 710696004217 homodimer interface [polypeptide binding]; other site 710696004218 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 710696004219 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 710696004220 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710696004221 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 710696004222 cell division protein FtsQ; Provisional; Region: PRK05529 710696004223 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 710696004224 cell division protein FtsZ; Validated; Region: PRK09330 710696004225 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 710696004226 nucleotide binding site [chemical binding]; other site 710696004227 SulA interaction site; other site 710696004228 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 710696004229 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 710696004230 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 710696004231 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710696004232 catalytic residue [active] 710696004233 Protein of unknown function (DUF552); Region: DUF552; pfam04472 710696004234 YGGT family; Region: YGGT; pfam02325 710696004235 DivIVA domain; Region: DivI1A_domain; TIGR03544 710696004236 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 710696004237 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 710696004238 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 710696004239 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 710696004240 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 710696004241 active site 710696004242 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 710696004243 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 710696004244 active site 710696004245 PHP Thumb interface [polypeptide binding]; other site 710696004246 metal binding site [ion binding]; metal-binding site 710696004247 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 710696004248 generic binding surface II; other site 710696004249 generic binding surface I; other site 710696004250 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 710696004251 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 710696004252 active site 710696004253 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 710696004254 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 710696004255 generic binding surface I; other site 710696004256 generic binding surface II; other site 710696004257 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 710696004258 putative active site [active] 710696004259 putative catalytic site [active] 710696004260 putative Mg binding site IVb [ion binding]; other site 710696004261 putative phosphate binding site [ion binding]; other site 710696004262 putative DNA binding site [nucleotide binding]; other site 710696004263 putative Mg binding site IVa [ion binding]; other site 710696004264 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 710696004265 Shikimate kinase; Region: SKI; pfam01202 710696004266 ATP-binding site [chemical binding]; other site 710696004267 Gluconate-6-phosphate binding site [chemical binding]; other site 710696004268 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 710696004269 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710696004270 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 710696004271 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 710696004272 NAD binding site [chemical binding]; other site 710696004273 dimerization interface [polypeptide binding]; other site 710696004274 product binding site; other site 710696004275 substrate binding site [chemical binding]; other site 710696004276 zinc binding site [ion binding]; other site 710696004277 catalytic residues [active] 710696004278 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 710696004279 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710696004280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696004281 homodimer interface [polypeptide binding]; other site 710696004282 catalytic residue [active] 710696004283 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 710696004284 putative active site pocket [active] 710696004285 4-fold oligomerization interface [polypeptide binding]; other site 710696004286 metal binding residues [ion binding]; metal-binding site 710696004287 3-fold/trimer interface [polypeptide binding]; other site 710696004288 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 710696004289 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 710696004290 putative active site [active] 710696004291 oxyanion strand; other site 710696004292 catalytic triad [active] 710696004293 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 710696004294 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 710696004295 catalytic residues [active] 710696004296 Protein of unknown function (DUF445); Region: DUF445; pfam04286 710696004297 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 710696004298 elongation factor G; Reviewed; Region: PRK12740 710696004299 G1 box; other site 710696004300 GTP/Mg2+ binding site [chemical binding]; other site 710696004301 G2 box; other site 710696004302 Switch I region; other site 710696004303 G3 box; other site 710696004304 Switch II region; other site 710696004305 G4 box; other site 710696004306 G5 box; other site 710696004307 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 710696004308 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 710696004309 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 710696004310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696004311 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710696004312 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 710696004313 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 710696004314 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 710696004315 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 710696004316 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 710696004317 23S rRNA binding site [nucleotide binding]; other site 710696004318 L21 binding site [polypeptide binding]; other site 710696004319 L13 binding site [polypeptide binding]; other site 710696004320 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 710696004321 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 710696004322 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 710696004323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710696004324 dimer interface [polypeptide binding]; other site 710696004325 phosphorylation site [posttranslational modification] 710696004326 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710696004327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696004328 ATP binding site [chemical binding]; other site 710696004329 Mg2+ binding site [ion binding]; other site 710696004330 G-X-G motif; other site 710696004331 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 710696004332 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 710696004333 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 710696004334 dimer interface [polypeptide binding]; other site 710696004335 motif 1; other site 710696004336 active site 710696004337 motif 2; other site 710696004338 motif 3; other site 710696004339 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 710696004340 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 710696004341 putative tRNA-binding site [nucleotide binding]; other site 710696004342 B3/4 domain; Region: B3_4; pfam03483 710696004343 tRNA synthetase B5 domain; Region: B5; pfam03484 710696004344 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 710696004345 dimer interface [polypeptide binding]; other site 710696004346 motif 1; other site 710696004347 motif 3; other site 710696004348 motif 2; other site 710696004349 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 710696004350 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 710696004351 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 710696004352 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 710696004353 heterotetramer interface [polypeptide binding]; other site 710696004354 active site pocket [active] 710696004355 cleavage site 710696004356 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 710696004357 feedback inhibition sensing region; other site 710696004358 homohexameric interface [polypeptide binding]; other site 710696004359 nucleotide binding site [chemical binding]; other site 710696004360 N-acetyl-L-glutamate binding site [chemical binding]; other site 710696004361 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 710696004362 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710696004363 inhibitor-cofactor binding pocket; inhibition site 710696004364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696004365 catalytic residue [active] 710696004366 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 710696004367 arginine repressor; Provisional; Region: PRK04280 710696004368 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 710696004369 argininosuccinate lyase; Provisional; Region: PRK00855 710696004370 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 710696004371 active sites [active] 710696004372 tetramer interface [polypeptide binding]; other site 710696004373 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 710696004374 active site 710696004375 DNA binding site [nucleotide binding] 710696004376 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 710696004377 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 710696004378 active site 710696004379 HIGH motif; other site 710696004380 dimer interface [polypeptide binding]; other site 710696004381 KMSKS motif; other site 710696004382 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710696004383 RNA binding surface [nucleotide binding]; other site 710696004384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 710696004385 Transposase; Region: DDE_Tnp_ISL3; pfam01610 710696004386 tetratricopeptide repeat protein; Provisional; Region: PRK11788 710696004387 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 710696004388 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710696004389 active site 710696004390 motif I; other site 710696004391 motif II; other site 710696004392 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710696004393 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 710696004394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696004395 S-adenosylmethionine binding site [chemical binding]; other site 710696004396 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 710696004397 ATP-NAD kinase; Region: NAD_kinase; pfam01513 710696004398 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 710696004399 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 710696004400 Walker A/P-loop; other site 710696004401 ATP binding site [chemical binding]; other site 710696004402 Q-loop/lid; other site 710696004403 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 710696004404 ABC transporter signature motif; other site 710696004405 Walker B; other site 710696004406 D-loop; other site 710696004407 H-loop/switch region; other site 710696004408 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 710696004409 Thiamine pyrophosphokinase; Region: TPK; cl08415 710696004410 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 710696004411 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 710696004412 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710696004413 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696004414 CTP synthetase; Validated; Region: pyrG; PRK05380 710696004415 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 710696004416 Catalytic site [active] 710696004417 active site 710696004418 UTP binding site [chemical binding]; other site 710696004419 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 710696004420 active site 710696004421 putative oxyanion hole; other site 710696004422 catalytic triad [active] 710696004423 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 710696004424 dimer interface [polypeptide binding]; other site 710696004425 ADP-ribose binding site [chemical binding]; other site 710696004426 active site 710696004427 nudix motif; other site 710696004428 metal binding site [ion binding]; metal-binding site 710696004429 hypothetical protein; Provisional; Region: PRK04233 710696004430 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710696004431 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 710696004432 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 710696004433 dimer interface [polypeptide binding]; other site 710696004434 anticodon binding site; other site 710696004435 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 710696004436 homodimer interface [polypeptide binding]; other site 710696004437 motif 1; other site 710696004438 active site 710696004439 motif 2; other site 710696004440 GAD domain; Region: GAD; pfam02938 710696004441 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710696004442 active site 710696004443 motif 3; other site 710696004444 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 710696004445 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710696004446 recombination factor protein RarA; Reviewed; Region: PRK13342 710696004447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696004448 Walker A motif; other site 710696004449 ATP binding site [chemical binding]; other site 710696004450 Walker B motif; other site 710696004451 arginine finger; other site 710696004452 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 710696004453 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 710696004454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696004455 dimer interface [polypeptide binding]; other site 710696004456 conserved gate region; other site 710696004457 putative PBP binding loops; other site 710696004458 ABC-ATPase subunit interface; other site 710696004459 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 710696004460 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 710696004461 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 710696004462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696004463 dimer interface [polypeptide binding]; other site 710696004464 conserved gate region; other site 710696004465 putative PBP binding loops; other site 710696004466 ABC-ATPase subunit interface; other site 710696004467 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 710696004468 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710696004469 Walker A/P-loop; other site 710696004470 ATP binding site [chemical binding]; other site 710696004471 Q-loop/lid; other site 710696004472 ABC transporter signature motif; other site 710696004473 Walker B; other site 710696004474 D-loop; other site 710696004475 H-loop/switch region; other site 710696004476 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710696004477 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 710696004478 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710696004479 Walker A/P-loop; other site 710696004480 ATP binding site [chemical binding]; other site 710696004481 Q-loop/lid; other site 710696004482 ABC transporter signature motif; other site 710696004483 Walker B; other site 710696004484 D-loop; other site 710696004485 H-loop/switch region; other site 710696004486 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710696004487 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 710696004488 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 710696004489 motif 1; other site 710696004490 active site 710696004491 motif 2; other site 710696004492 motif 3; other site 710696004493 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 710696004494 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 710696004495 YceG-like family; Region: YceG; pfam02618 710696004496 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 710696004497 dimerization interface [polypeptide binding]; other site 710696004498 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 710696004499 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 710696004500 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 710696004501 shikimate binding site; other site 710696004502 NAD(P) binding site [chemical binding]; other site 710696004503 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 710696004504 chorismate synthase; Validated; Region: PRK05382 710696004505 Tetramer interface [polypeptide binding]; other site 710696004506 active site 710696004507 FMN-binding site [chemical binding]; other site 710696004508 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 710696004509 Shikimate kinase; Region: SKI; pfam01202 710696004510 ADP binding site [chemical binding]; other site 710696004511 magnesium binding site [ion binding]; other site 710696004512 putative shikimate binding site; other site 710696004513 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 710696004514 active site 710696004515 dimer interface [polypeptide binding]; other site 710696004516 metal binding site [ion binding]; metal-binding site 710696004517 Dehydroquinase class II; Region: DHquinase_II; pfam01220 710696004518 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 710696004519 trimer interface [polypeptide binding]; other site 710696004520 active site 710696004521 dimer interface [polypeptide binding]; other site 710696004522 Part of AAA domain; Region: AAA_19; pfam13245 710696004523 elongation factor P; Validated; Region: PRK00529 710696004524 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 710696004525 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 710696004526 RNA binding site [nucleotide binding]; other site 710696004527 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 710696004528 RNA binding site [nucleotide binding]; other site 710696004529 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 710696004530 putative RNA binding site [nucleotide binding]; other site 710696004531 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 710696004532 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 710696004533 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 710696004534 active site 710696004535 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 710696004536 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 710696004537 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 710696004538 dihydroorotase; Validated; Region: pyrC; PRK09357 710696004539 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710696004540 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 710696004541 active site 710696004542 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 710696004543 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 710696004544 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 710696004545 catalytic site [active] 710696004546 subunit interface [polypeptide binding]; other site 710696004547 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 710696004548 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710696004549 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 710696004550 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 710696004551 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710696004552 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710696004553 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 710696004554 IMP binding site; other site 710696004555 dimer interface [polypeptide binding]; other site 710696004556 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 710696004557 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 710696004558 FAD binding pocket [chemical binding]; other site 710696004559 conserved FAD binding motif [chemical binding]; other site 710696004560 phosphate binding motif [ion binding]; other site 710696004561 beta-alpha-beta structure motif; other site 710696004562 NAD binding pocket [chemical binding]; other site 710696004563 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710696004564 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 710696004565 phosphate binding site [ion binding]; other site 710696004566 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 710696004567 active site 710696004568 dimer interface [polypeptide binding]; other site 710696004569 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 710696004570 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 710696004571 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 710696004572 catalytic site [active] 710696004573 G-X2-G-X-G-K; other site 710696004574 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 710696004575 Flavoprotein; Region: Flavoprotein; pfam02441 710696004576 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 710696004577 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 710696004578 S-adenosylmethionine synthetase; Validated; Region: PRK05250 710696004579 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 710696004580 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 710696004581 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 710696004582 primosome assembly protein PriA; Provisional; Region: PRK14873 710696004583 ADDz for ATRX, Dnmt3 and Dnmt3l PHD-like zinc finger domain; Region: ADDz; cl17040 710696004584 peptide binding site [polypeptide binding]; other site 710696004585 Uncharacterized conserved protein [Function unknown]; Region: COG3268 710696004586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696004587 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 710696004588 active site 710696004589 catalytic residues [active] 710696004590 metal binding site [ion binding]; metal-binding site 710696004591 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 710696004592 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 710696004593 putative active site [active] 710696004594 substrate binding site [chemical binding]; other site 710696004595 putative cosubstrate binding site; other site 710696004596 catalytic site [active] 710696004597 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 710696004598 substrate binding site [chemical binding]; other site 710696004599 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 710696004600 putative RNA binding site [nucleotide binding]; other site 710696004601 16S rRNA methyltransferase B; Provisional; Region: PRK14902 710696004602 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 710696004603 enoyl-CoA hydratase; Provisional; Region: PRK06688 710696004604 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710696004605 substrate binding site [chemical binding]; other site 710696004606 oxyanion hole (OAH) forming residues; other site 710696004607 trimer interface [polypeptide binding]; other site 710696004608 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 710696004609 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 710696004610 substrate binding site [chemical binding]; other site 710696004611 hexamer interface [polypeptide binding]; other site 710696004612 metal binding site [ion binding]; metal-binding site 710696004613 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 710696004614 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 710696004615 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 710696004616 catalytic motif [active] 710696004617 Zn binding site [ion binding]; other site 710696004618 RibD C-terminal domain; Region: RibD_C; pfam01872 710696004619 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 710696004620 Lumazine binding domain; Region: Lum_binding; pfam00677 710696004621 Lumazine binding domain; Region: Lum_binding; pfam00677 710696004622 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 710696004623 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 710696004624 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 710696004625 dimerization interface [polypeptide binding]; other site 710696004626 active site 710696004627 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 710696004628 homopentamer interface [polypeptide binding]; other site 710696004629 active site 710696004630 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 710696004631 metal binding site [ion binding]; metal-binding site 710696004632 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 710696004633 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 710696004634 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 710696004635 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 710696004636 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 710696004637 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 710696004638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696004639 putative substrate translocation pore; other site 710696004640 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 710696004641 AAA domain; Region: AAA_18; pfam13238 710696004642 active site 710696004643 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 710696004644 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 710696004645 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 710696004646 substrate binding site [chemical binding]; other site 710696004647 glutamase interaction surface [polypeptide binding]; other site 710696004648 TIGR03085 family protein; Region: TIGR03085 710696004649 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 710696004650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696004651 Coenzyme A binding pocket [chemical binding]; other site 710696004652 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710696004653 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710696004654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696004655 Walker A/P-loop; other site 710696004656 ATP binding site [chemical binding]; other site 710696004657 Q-loop/lid; other site 710696004658 ABC transporter signature motif; other site 710696004659 Walker B; other site 710696004660 D-loop; other site 710696004661 H-loop/switch region; other site 710696004662 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710696004663 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710696004664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696004665 Walker A/P-loop; other site 710696004666 ATP binding site [chemical binding]; other site 710696004667 Q-loop/lid; other site 710696004668 ABC transporter signature motif; other site 710696004669 Walker B; other site 710696004670 D-loop; other site 710696004671 H-loop/switch region; other site 710696004672 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 710696004673 anthranilate synthase component I; Provisional; Region: PRK13571 710696004674 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 710696004675 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 710696004676 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 710696004677 active site 710696004678 ribulose/triose binding site [chemical binding]; other site 710696004679 phosphate binding site [ion binding]; other site 710696004680 substrate (anthranilate) binding pocket [chemical binding]; other site 710696004681 product (indole) binding pocket [chemical binding]; other site 710696004682 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 710696004683 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 710696004684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696004685 catalytic residue [active] 710696004686 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 710696004687 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 710696004688 substrate binding site [chemical binding]; other site 710696004689 active site 710696004690 catalytic residues [active] 710696004691 heterodimer interface [polypeptide binding]; other site 710696004692 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 710696004693 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 710696004694 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 710696004695 active site 710696004696 dimer interface [polypeptide binding]; other site 710696004697 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 710696004698 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 710696004699 active site 710696004700 FMN binding site [chemical binding]; other site 710696004701 substrate binding site [chemical binding]; other site 710696004702 3Fe-4S cluster binding site [ion binding]; other site 710696004703 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 710696004704 domain interface; other site 710696004705 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 710696004706 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710696004707 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 710696004708 pyruvate kinase; Provisional; Region: PRK06247 710696004709 domain interfaces; other site 710696004710 active site 710696004711 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 710696004712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696004713 active site 710696004714 phosphorylation site [posttranslational modification] 710696004715 intermolecular recognition site; other site 710696004716 dimerization interface [polypeptide binding]; other site 710696004717 ANTAR domain; Region: ANTAR; pfam03861 710696004718 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 710696004719 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 710696004720 dimerization interface [polypeptide binding]; other site 710696004721 ligand binding site [chemical binding]; other site 710696004722 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710696004723 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 710696004724 TM-ABC transporter signature motif; other site 710696004725 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 710696004726 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 710696004727 TM-ABC transporter signature motif; other site 710696004728 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 710696004729 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 710696004730 Walker A/P-loop; other site 710696004731 ATP binding site [chemical binding]; other site 710696004732 Q-loop/lid; other site 710696004733 ABC transporter signature motif; other site 710696004734 Walker B; other site 710696004735 D-loop; other site 710696004736 H-loop/switch region; other site 710696004737 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 710696004738 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 710696004739 Walker A/P-loop; other site 710696004740 ATP binding site [chemical binding]; other site 710696004741 Q-loop/lid; other site 710696004742 ABC transporter signature motif; other site 710696004743 Walker B; other site 710696004744 D-loop; other site 710696004745 H-loop/switch region; other site 710696004746 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 710696004747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696004748 Coenzyme A binding pocket [chemical binding]; other site 710696004749 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710696004750 CoenzymeA binding site [chemical binding]; other site 710696004751 subunit interaction site [polypeptide binding]; other site 710696004752 PHB binding site; other site 710696004753 DNA polymerase I; Provisional; Region: PRK05755 710696004754 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 710696004755 active site 710696004756 metal binding site 1 [ion binding]; metal-binding site 710696004757 putative 5' ssDNA interaction site; other site 710696004758 metal binding site 3; metal-binding site 710696004759 metal binding site 2 [ion binding]; metal-binding site 710696004760 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 710696004761 putative DNA binding site [nucleotide binding]; other site 710696004762 putative metal binding site [ion binding]; other site 710696004763 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 710696004764 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 710696004765 active site 710696004766 DNA binding site [nucleotide binding] 710696004767 catalytic site [active] 710696004768 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696004769 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710696004770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696004771 S-adenosylmethionine binding site [chemical binding]; other site 710696004772 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 710696004773 Acyltransferase family; Region: Acyl_transf_3; pfam01757 710696004774 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 710696004775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696004776 S-adenosylmethionine binding site [chemical binding]; other site 710696004777 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 710696004778 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 710696004779 RNA binding site [nucleotide binding]; other site 710696004780 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 710696004781 RNA binding site [nucleotide binding]; other site 710696004782 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 710696004783 RNA binding site [nucleotide binding]; other site 710696004784 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 710696004785 RNA binding site [nucleotide binding]; other site 710696004786 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 710696004787 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 710696004788 active site 710696004789 catalytic site [active] 710696004790 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 710696004791 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 710696004792 CoA-binding site [chemical binding]; other site 710696004793 ATP-binding [chemical binding]; other site 710696004794 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 710696004795 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 710696004796 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 710696004797 excinuclease ABC subunit B; Provisional; Region: PRK05298 710696004798 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710696004799 putative Mg++ binding site [ion binding]; other site 710696004800 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710696004801 nucleotide binding region [chemical binding]; other site 710696004802 ATP-binding site [chemical binding]; other site 710696004803 Ultra-violet resistance protein B; Region: UvrB; pfam12344 710696004804 UvrB/uvrC motif; Region: UVR; pfam02151 710696004805 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 710696004806 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 710696004807 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710696004808 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 710696004809 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710696004810 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 710696004811 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 710696004812 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 710696004813 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 710696004814 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 710696004815 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 710696004816 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 710696004817 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 710696004818 iron-sulfur cluster [ion binding]; other site 710696004819 [2Fe-2S] cluster binding site [ion binding]; other site 710696004820 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 710696004821 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 710696004822 GIY-YIG motif/motif A; other site 710696004823 active site 710696004824 catalytic site [active] 710696004825 putative DNA binding site [nucleotide binding]; other site 710696004826 metal binding site [ion binding]; metal-binding site 710696004827 UvrB/uvrC motif; Region: UVR; pfam02151 710696004828 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 710696004829 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 710696004830 Helix-hairpin-helix motif; Region: HHH; pfam00633 710696004831 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 710696004832 AAA domain; Region: AAA_18; pfam13238 710696004833 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 710696004834 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 710696004835 phosphate binding site [ion binding]; other site 710696004836 putative substrate binding pocket [chemical binding]; other site 710696004837 dimer interface [polypeptide binding]; other site 710696004838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 710696004839 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 710696004840 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 710696004841 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 710696004842 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 710696004843 Phosphoglycerate kinase; Region: PGK; pfam00162 710696004844 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 710696004845 substrate binding site [chemical binding]; other site 710696004846 hinge regions; other site 710696004847 ADP binding site [chemical binding]; other site 710696004848 catalytic site [active] 710696004849 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 710696004850 triosephosphate isomerase; Provisional; Region: PRK14565 710696004851 substrate binding site [chemical binding]; other site 710696004852 dimer interface [polypeptide binding]; other site 710696004853 catalytic triad [active] 710696004854 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 710696004855 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 710696004856 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 710696004857 putative active site [active] 710696004858 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 710696004859 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 710696004860 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 710696004861 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 710696004862 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 710696004863 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 710696004864 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 710696004865 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 710696004866 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 710696004867 putative active site [active] 710696004868 transaldolase; Provisional; Region: PRK03903 710696004869 catalytic residue [active] 710696004870 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 710696004871 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 710696004872 TPP-binding site [chemical binding]; other site 710696004873 dimer interface [polypeptide binding]; other site 710696004874 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 710696004875 PYR/PP interface [polypeptide binding]; other site 710696004876 dimer interface [polypeptide binding]; other site 710696004877 TPP binding site [chemical binding]; other site 710696004878 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710696004879 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 710696004880 UbiA prenyltransferase family; Region: UbiA; pfam01040 710696004881 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 710696004882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696004883 Coenzyme A binding pocket [chemical binding]; other site 710696004884 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 710696004885 nudix motif; other site 710696004886 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 710696004887 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 710696004888 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710696004889 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 710696004890 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710696004891 Walker A/P-loop; other site 710696004892 ATP binding site [chemical binding]; other site 710696004893 Q-loop/lid; other site 710696004894 ABC transporter signature motif; other site 710696004895 Walker B; other site 710696004896 D-loop; other site 710696004897 H-loop/switch region; other site 710696004898 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 710696004899 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 710696004900 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 710696004901 Predicted transcriptional regulator [Transcription]; Region: COG2345 710696004902 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696004903 putative DNA binding site [nucleotide binding]; other site 710696004904 putative Zn2+ binding site [ion binding]; other site 710696004905 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 710696004906 FeS assembly protein SufB; Region: sufB; TIGR01980 710696004907 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 710696004908 FeS assembly protein SufD; Region: sufD; TIGR01981 710696004909 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 710696004910 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 710696004911 Walker A/P-loop; other site 710696004912 ATP binding site [chemical binding]; other site 710696004913 Q-loop/lid; other site 710696004914 ABC transporter signature motif; other site 710696004915 Walker B; other site 710696004916 D-loop; other site 710696004917 H-loop/switch region; other site 710696004918 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 710696004919 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 710696004920 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710696004921 catalytic residue [active] 710696004922 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 710696004923 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 710696004924 trimerization site [polypeptide binding]; other site 710696004925 active site 710696004926 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 710696004927 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 710696004928 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 710696004929 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710696004930 catalytic residue [active] 710696004931 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 710696004932 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 710696004933 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 710696004934 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710696004935 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710696004936 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710696004937 Uncharacterized conserved protein (DUF2349); Region: DUF2349; pfam09779 710696004938 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 710696004939 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710696004940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696004941 Walker A/P-loop; other site 710696004942 ATP binding site [chemical binding]; other site 710696004943 Q-loop/lid; other site 710696004944 ABC transporter signature motif; other site 710696004945 Walker B; other site 710696004946 D-loop; other site 710696004947 H-loop/switch region; other site 710696004948 Protein of unknown function (DUF664); Region: DUF664; pfam04978 710696004949 DinB superfamily; Region: DinB_2; pfam12867 710696004950 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 710696004951 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 710696004952 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710696004953 FeS/SAM binding site; other site 710696004954 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 710696004955 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 710696004956 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 710696004957 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 710696004958 NAD(P) binding site [chemical binding]; other site 710696004959 homotetramer interface [polypeptide binding]; other site 710696004960 homodimer interface [polypeptide binding]; other site 710696004961 active site 710696004962 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 710696004963 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 710696004964 NAD binding site [chemical binding]; other site 710696004965 homotetramer interface [polypeptide binding]; other site 710696004966 homodimer interface [polypeptide binding]; other site 710696004967 substrate binding site [chemical binding]; other site 710696004968 active site 710696004969 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 710696004970 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 710696004971 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 710696004972 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710696004973 motif II; other site 710696004974 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 710696004975 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710696004976 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710696004977 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 710696004978 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 710696004979 ligand binding site; other site 710696004980 oligomer interface; other site 710696004981 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 710696004982 dimer interface [polypeptide binding]; other site 710696004983 N-terminal domain interface [polypeptide binding]; other site 710696004984 sulfate 1 binding site; other site 710696004985 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 710696004986 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710696004987 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 710696004988 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 710696004989 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 710696004990 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696004991 Walker A/P-loop; other site 710696004992 ATP binding site [chemical binding]; other site 710696004993 Q-loop/lid; other site 710696004994 ABC transporter signature motif; other site 710696004995 Walker B; other site 710696004996 D-loop; other site 710696004997 H-loop/switch region; other site 710696004998 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 710696004999 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 710696005000 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 710696005001 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 710696005002 hypothetical protein; Provisional; Region: PRK10621 710696005003 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 710696005004 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 710696005005 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 710696005006 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710696005007 catalytic core [active] 710696005008 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 710696005009 putative substrate binding site [chemical binding]; other site 710696005010 putative ATP binding site [chemical binding]; other site 710696005011 hypothetical protein; Provisional; Region: PRK07906 710696005012 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 710696005013 putative metal binding site [ion binding]; other site 710696005014 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 710696005015 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710696005016 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710696005017 active site 710696005018 catalytic tetrad [active] 710696005019 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710696005020 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 710696005021 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 710696005022 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 710696005023 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 710696005024 oligomer interface [polypeptide binding]; other site 710696005025 metal binding site [ion binding]; metal-binding site 710696005026 metal binding site [ion binding]; metal-binding site 710696005027 putative Cl binding site [ion binding]; other site 710696005028 basic sphincter; other site 710696005029 hydrophobic gate; other site 710696005030 periplasmic entrance; other site 710696005031 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710696005032 catalytic core [active] 710696005033 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 710696005034 conserved hypothetical protein; Region: TIGR03843 710696005035 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710696005036 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 710696005037 active site 710696005038 HIGH motif; other site 710696005039 nucleotide binding site [chemical binding]; other site 710696005040 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710696005041 active site 710696005042 KMSKS motif; other site 710696005043 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 710696005044 putative tRNA binding surface [nucleotide binding]; other site 710696005045 PAC2 family; Region: PAC2; pfam09754 710696005046 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 710696005047 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 710696005048 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 710696005049 substrate binding pocket [chemical binding]; other site 710696005050 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 710696005051 B12 binding site [chemical binding]; other site 710696005052 cobalt ligand [ion binding]; other site 710696005053 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 710696005054 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 710696005055 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710696005056 active site 710696005057 motif I; other site 710696005058 motif II; other site 710696005059 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 710696005060 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710696005061 DNA-binding site [nucleotide binding]; DNA binding site 710696005062 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710696005063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696005064 homodimer interface [polypeptide binding]; other site 710696005065 catalytic residue [active] 710696005066 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 710696005067 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 710696005068 tetrameric interface [polypeptide binding]; other site 710696005069 NAD binding site [chemical binding]; other site 710696005070 catalytic residues [active] 710696005071 hypothetical protein; Provisional; Region: PRK06062 710696005072 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710696005073 inhibitor-cofactor binding pocket; inhibition site 710696005074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696005075 catalytic residue [active] 710696005076 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 710696005077 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 710696005078 active site 710696005079 putative substrate binding region [chemical binding]; other site 710696005080 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 710696005081 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 710696005082 dimer interface [polypeptide binding]; other site 710696005083 ssDNA binding site [nucleotide binding]; other site 710696005084 tetramer (dimer of dimers) interface [polypeptide binding]; other site 710696005085 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 710696005086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696005087 S-adenosylmethionine binding site [chemical binding]; other site 710696005088 proteasome ATPase; Region: pup_AAA; TIGR03689 710696005089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696005090 Walker A motif; other site 710696005091 ATP binding site [chemical binding]; other site 710696005092 Walker B motif; other site 710696005093 arginine finger; other site 710696005094 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 710696005095 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 710696005096 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 710696005097 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710696005098 active site 710696005099 Pup-ligase protein; Region: Pup_ligase; cl15463 710696005100 Pup-like protein; Region: Pup; pfam05639 710696005101 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 710696005102 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 710696005103 active site 710696005104 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 710696005105 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 710696005106 active site 710696005107 cell division protein GpsB; Provisional; Region: PRK14127 710696005108 DivIVA domain; Region: DivI1A_domain; TIGR03544 710696005109 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 710696005110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696005111 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710696005112 NAD(P) binding site [chemical binding]; other site 710696005113 active site 710696005114 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 710696005115 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 710696005116 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 710696005117 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 710696005118 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 710696005119 Predicted transcriptional regulator [Transcription]; Region: COG2378 710696005120 WYL domain; Region: WYL; pfam13280 710696005121 Predicted transcriptional regulator [Transcription]; Region: COG2378 710696005122 WYL domain; Region: WYL; pfam13280 710696005123 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 710696005124 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 710696005125 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 710696005126 diacylglycerol kinase; Reviewed; Region: PRK11914 710696005127 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 710696005128 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 710696005129 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710696005130 ATP binding site [chemical binding]; other site 710696005131 putative Mg++ binding site [ion binding]; other site 710696005132 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 710696005133 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710696005134 nucleotide binding region [chemical binding]; other site 710696005135 ATP-binding site [chemical binding]; other site 710696005136 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 710696005137 5'-3' exonuclease; Region: 53EXOc; smart00475 710696005138 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 710696005139 active site 710696005140 metal binding site 1 [ion binding]; metal-binding site 710696005141 putative 5' ssDNA interaction site; other site 710696005142 metal binding site 3; metal-binding site 710696005143 metal binding site 2 [ion binding]; metal-binding site 710696005144 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 710696005145 putative DNA binding site [nucleotide binding]; other site 710696005146 putative metal binding site [ion binding]; other site 710696005147 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 710696005148 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696005149 putative DNA binding site [nucleotide binding]; other site 710696005150 putative Zn2+ binding site [ion binding]; other site 710696005151 AsnC family; Region: AsnC_trans_reg; pfam01037 710696005152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696005153 putative substrate translocation pore; other site 710696005154 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 710696005155 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 710696005156 putative deacylase active site [active] 710696005157 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710696005158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696005159 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 710696005160 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 710696005161 Enoylreductase; Region: PKS_ER; smart00829 710696005162 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 710696005163 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 710696005164 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 710696005165 B12 binding site [chemical binding]; other site 710696005166 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710696005167 active site 2 [active] 710696005168 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 710696005169 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 710696005170 putative active site [active] 710696005171 catalytic triad [active] 710696005172 putative dimer interface [polypeptide binding]; other site 710696005173 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 710696005174 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 710696005175 Ligand binding site; other site 710696005176 Putative Catalytic site; other site 710696005177 DXD motif; other site 710696005178 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 710696005179 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 710696005180 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 710696005181 YwiC-like protein; Region: YwiC; pfam14256 710696005182 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 710696005183 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710696005184 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 710696005185 Walker A/P-loop; other site 710696005186 ATP binding site [chemical binding]; other site 710696005187 Q-loop/lid; other site 710696005188 ABC transporter signature motif; other site 710696005189 Walker B; other site 710696005190 D-loop; other site 710696005191 H-loop/switch region; other site 710696005192 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 710696005193 putative DNA binding site [nucleotide binding]; other site 710696005194 putative Zn2+ binding site [ion binding]; other site 710696005195 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 710696005196 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 710696005197 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 710696005198 trehalose synthase; Region: treS_nterm; TIGR02456 710696005199 active site 710696005200 catalytic site [active] 710696005201 Fic family protein [Function unknown]; Region: COG3177 710696005202 Fic/DOC family; Region: Fic; pfam02661 710696005203 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 710696005204 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710696005205 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 710696005206 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 710696005207 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 710696005208 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 710696005209 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 710696005210 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 710696005211 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 710696005212 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710696005213 catalytic core [active] 710696005214 glycine dehydrogenase; Provisional; Region: PRK05367 710696005215 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 710696005216 tetramer interface [polypeptide binding]; other site 710696005217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696005218 catalytic residue [active] 710696005219 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 710696005220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696005221 tetramer interface [polypeptide binding]; other site 710696005222 catalytic residue [active] 710696005223 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 710696005224 DNA binding residues [nucleotide binding] 710696005225 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710696005226 putative dimer interface [polypeptide binding]; other site 710696005227 Bifunctional nuclease; Region: DNase-RNase; pfam02577 710696005228 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 710696005229 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710696005230 DNA binding residues [nucleotide binding] 710696005231 dimer interface [polypeptide binding]; other site 710696005232 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710696005233 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710696005234 phosphopeptide binding site; other site 710696005235 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 710696005236 lipoyl attachment site [posttranslational modification]; other site 710696005237 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 710696005238 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 710696005239 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 710696005240 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 710696005241 YibE/F-like protein; Region: YibE_F; pfam07907 710696005242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696005243 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710696005244 putative substrate translocation pore; other site 710696005245 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 710696005246 active site 710696005247 catalytic residues [active] 710696005248 metal binding site [ion binding]; metal-binding site 710696005249 Isochorismatase family; Region: Isochorismatase; pfam00857 710696005250 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 710696005251 catalytic triad [active] 710696005252 conserved cis-peptide bond; other site 710696005253 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 710696005254 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 710696005255 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 710696005256 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 710696005257 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 710696005258 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710696005259 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710696005260 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710696005261 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710696005262 DNA-binding site [nucleotide binding]; DNA binding site 710696005263 FCD domain; Region: FCD; pfam07729 710696005264 GTP-binding protein Der; Reviewed; Region: PRK03003 710696005265 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 710696005266 G1 box; other site 710696005267 GTP/Mg2+ binding site [chemical binding]; other site 710696005268 Switch I region; other site 710696005269 G2 box; other site 710696005270 Switch II region; other site 710696005271 G3 box; other site 710696005272 G4 box; other site 710696005273 G5 box; other site 710696005274 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 710696005275 G1 box; other site 710696005276 GTP/Mg2+ binding site [chemical binding]; other site 710696005277 Switch I region; other site 710696005278 G2 box; other site 710696005279 G3 box; other site 710696005280 Switch II region; other site 710696005281 G4 box; other site 710696005282 G5 box; other site 710696005283 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710696005284 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710696005285 putative acyl-acceptor binding pocket; other site 710696005286 cytidylate kinase; Provisional; Region: cmk; PRK00023 710696005287 AAA domain; Region: AAA_17; cl17253 710696005288 Cytidylate kinase; Region: Cytidylate_kin; pfam02224 710696005289 prephenate dehydrogenase; Validated; Region: PRK06545 710696005290 prephenate dehydrogenase; Validated; Region: PRK08507 710696005291 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 710696005292 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 710696005293 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710696005294 RNA binding surface [nucleotide binding]; other site 710696005295 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 710696005296 active site 710696005297 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 710696005298 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 710696005299 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710696005300 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710696005301 P-loop; other site 710696005302 Magnesium ion binding site [ion binding]; other site 710696005303 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710696005304 Magnesium ion binding site [ion binding]; other site 710696005305 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 710696005306 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 710696005307 active site 710696005308 Int/Topo IB signature motif; other site 710696005309 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 710696005310 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 710696005311 hexamer interface [polypeptide binding]; other site 710696005312 ligand binding site [chemical binding]; other site 710696005313 putative active site [active] 710696005314 NAD(P) binding site [chemical binding]; other site 710696005315 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 710696005316 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 710696005317 dimer interface [polypeptide binding]; other site 710696005318 motif 1; other site 710696005319 active site 710696005320 motif 2; other site 710696005321 motif 3; other site 710696005322 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 710696005323 anticodon binding site; other site 710696005324 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 710696005325 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 710696005326 active site 710696005327 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 710696005328 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 710696005329 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 710696005330 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710696005331 Zn2+ binding site [ion binding]; other site 710696005332 Mg2+ binding site [ion binding]; other site 710696005333 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 710696005334 synthetase active site [active] 710696005335 NTP binding site [chemical binding]; other site 710696005336 metal binding site [ion binding]; metal-binding site 710696005337 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 710696005338 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 710696005339 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710696005340 active site 710696005341 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 710696005342 Protein export membrane protein; Region: SecD_SecF; pfam02355 710696005343 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 710696005344 Protein export membrane protein; Region: SecD_SecF; cl14618 710696005345 Preprotein translocase subunit; Region: YajC; pfam02699 710696005346 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 710696005347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696005348 Walker A motif; other site 710696005349 ATP binding site [chemical binding]; other site 710696005350 Walker B motif; other site 710696005351 arginine finger; other site 710696005352 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 710696005353 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 710696005354 RuvA N terminal domain; Region: RuvA_N; pfam01330 710696005355 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 710696005356 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 710696005357 active site 710696005358 putative DNA-binding cleft [nucleotide binding]; other site 710696005359 dimer interface [polypeptide binding]; other site 710696005360 hypothetical protein; Validated; Region: PRK00110 710696005361 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 710696005362 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 710696005363 predicted active site [active] 710696005364 catalytic triad [active] 710696005365 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 710696005366 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 710696005367 active site 710696005368 multimer interface [polypeptide binding]; other site 710696005369 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696005370 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710696005371 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 710696005372 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 710696005373 putative acyl-acceptor binding pocket; other site 710696005374 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 710696005375 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 710696005376 nucleotide binding site/active site [active] 710696005377 HIT family signature motif; other site 710696005378 catalytic residue [active] 710696005379 Cytochrome c552; Region: Cytochrom_C552; pfam02335 710696005380 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 710696005381 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 710696005382 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 710696005383 DNA binding residues [nucleotide binding] 710696005384 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 710696005385 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 710696005386 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710696005387 catalytic residues [active] 710696005388 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 710696005389 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 710696005390 ResB-like family; Region: ResB; pfam05140 710696005391 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 710696005392 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 710696005393 TPR repeat; Region: TPR_11; pfam13414 710696005394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 710696005395 binding surface 710696005396 TPR motif; other site 710696005397 TPR repeat; Region: TPR_11; pfam13414 710696005398 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 710696005399 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 710696005400 Uncharacterized conserved protein [Function unknown]; Region: COG3391 710696005401 NHL repeat; Region: NHL; pfam01436 710696005402 NHL repeat; Region: NHL; pfam01436 710696005403 NHL repeat; Region: NHL; pfam01436 710696005404 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 710696005405 TPR motif; other site 710696005406 Tetratricopeptide repeat; Region: TPR_16; pfam13432 710696005407 binding surface 710696005408 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 710696005409 binding surface 710696005410 TPR motif; other site 710696005411 TPR repeat; Region: TPR_11; pfam13414 710696005412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 710696005413 binding surface 710696005414 TPR motif; other site 710696005415 Tetratricopeptide repeat; Region: TPR_16; pfam13432 710696005416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 710696005417 Histidine kinase; Region: HisKA_3; pfam07730 710696005418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696005419 ATP binding site [chemical binding]; other site 710696005420 Mg2+ binding site [ion binding]; other site 710696005421 G-X-G motif; other site 710696005422 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710696005423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696005424 active site 710696005425 phosphorylation site [posttranslational modification] 710696005426 intermolecular recognition site; other site 710696005427 dimerization interface [polypeptide binding]; other site 710696005428 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710696005429 DNA binding residues [nucleotide binding] 710696005430 dimerization interface [polypeptide binding]; other site 710696005431 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710696005432 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 710696005433 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 710696005434 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 710696005435 active site 710696005436 dimer interface [polypeptide binding]; other site 710696005437 motif 1; other site 710696005438 motif 2; other site 710696005439 motif 3; other site 710696005440 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 710696005441 anticodon binding site; other site 710696005442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710696005443 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710696005444 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 710696005445 NAD(P) binding site [chemical binding]; other site 710696005446 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710696005447 active site 2 [active] 710696005448 active site 1 [active] 710696005449 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 710696005450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696005451 NAD(P) binding site [chemical binding]; other site 710696005452 active site 710696005453 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 710696005454 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710696005455 dimer interface [polypeptide binding]; other site 710696005456 active site 710696005457 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710696005458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696005459 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 710696005460 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 710696005461 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 710696005462 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 710696005463 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 710696005464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696005465 catalytic residue [active] 710696005466 aminodeoxychorismate synthase; Provisional; Region: PRK07508 710696005467 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 710696005468 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 710696005469 catalytic residues [active] 710696005470 dimer interface [polypeptide binding]; other site 710696005471 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 710696005472 nucleotide binding site [chemical binding]; other site 710696005473 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 710696005474 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710696005475 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710696005476 active site 710696005477 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 710696005478 hypothetical protein; Provisional; Region: PRK14059 710696005479 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 710696005480 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710696005481 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 710696005482 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 710696005483 SelR domain; Region: SelR; pfam01641 710696005484 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 710696005485 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 710696005486 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710696005487 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 710696005488 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 710696005489 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 710696005490 substrate binding site [chemical binding]; other site 710696005491 active site 710696005492 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 710696005493 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 710696005494 catalytic site [active] 710696005495 putative active site [active] 710696005496 putative substrate binding site [chemical binding]; other site 710696005497 HRDC domain; Region: HRDC; pfam00570 710696005498 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710696005499 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 710696005500 dimer interface [polypeptide binding]; other site 710696005501 active site 710696005502 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710696005503 substrate binding site [chemical binding]; other site 710696005504 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 710696005505 oxyanion hole (OAH) forming residues; other site 710696005506 trimer interface [polypeptide binding]; other site 710696005507 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 710696005508 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 710696005509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696005510 NADH(P)-binding; Region: NAD_binding_10; pfam13460 710696005511 NAD(P) binding site [chemical binding]; other site 710696005512 active site 710696005513 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710696005514 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710696005515 non-specific DNA binding site [nucleotide binding]; other site 710696005516 salt bridge; other site 710696005517 sequence-specific DNA binding site [nucleotide binding]; other site 710696005518 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 710696005519 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 710696005520 putative active site [active] 710696005521 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 710696005522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696005523 NAD(P) binding site [chemical binding]; other site 710696005524 active site 710696005525 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710696005526 GAF domain; Region: GAF; pfam01590 710696005527 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710696005528 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710696005529 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 710696005530 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 710696005531 TM-ABC transporter signature motif; other site 710696005532 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710696005533 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 710696005534 TM-ABC transporter signature motif; other site 710696005535 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 710696005536 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 710696005537 Walker A/P-loop; other site 710696005538 ATP binding site [chemical binding]; other site 710696005539 Q-loop/lid; other site 710696005540 ABC transporter signature motif; other site 710696005541 Walker B; other site 710696005542 D-loop; other site 710696005543 H-loop/switch region; other site 710696005544 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 710696005545 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 710696005546 Walker A/P-loop; other site 710696005547 ATP binding site [chemical binding]; other site 710696005548 Q-loop/lid; other site 710696005549 ABC transporter signature motif; other site 710696005550 Walker B; other site 710696005551 D-loop; other site 710696005552 H-loop/switch region; other site 710696005553 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 710696005554 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 710696005555 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 710696005556 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 710696005557 TPP-binding site; other site 710696005558 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 710696005559 PYR/PP interface [polypeptide binding]; other site 710696005560 dimer interface [polypeptide binding]; other site 710696005561 TPP binding site [chemical binding]; other site 710696005562 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710696005563 aconitate hydratase; Validated; Region: PRK09277 710696005564 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 710696005565 substrate binding site [chemical binding]; other site 710696005566 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 710696005567 ligand binding site [chemical binding]; other site 710696005568 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 710696005569 substrate binding site [chemical binding]; other site 710696005570 TRAM domain; Region: TRAM; pfam01938 710696005571 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 710696005572 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 710696005573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696005574 S-adenosylmethionine binding site [chemical binding]; other site 710696005575 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710696005576 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 710696005577 TrkA-N domain; Region: TrkA_N; pfam02254 710696005578 TrkA-C domain; Region: TrkA_C; pfam02080 710696005579 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 710696005580 TrkA-N domain; Region: TrkA_N; pfam02254 710696005581 TrkA-C domain; Region: TrkA_C; pfam02080 710696005582 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 710696005583 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 710696005584 generic binding surface II; other site 710696005585 generic binding surface I; other site 710696005586 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 710696005587 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 710696005588 trimer interface [polypeptide binding]; other site 710696005589 active site 710696005590 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 710696005591 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 710696005592 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 710696005593 active site 710696005594 dimerization interface [polypeptide binding]; other site 710696005595 ferrochelatase; Reviewed; Region: hemH; PRK00035 710696005596 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 710696005597 C-terminal domain interface [polypeptide binding]; other site 710696005598 active site 710696005599 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 710696005600 active site 710696005601 N-terminal domain interface [polypeptide binding]; other site 710696005602 UPF0126 domain; Region: UPF0126; pfam03458 710696005603 Predicted membrane protein [Function unknown]; Region: COG2860 710696005604 UPF0126 domain; Region: UPF0126; pfam03458 710696005605 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 710696005606 thymidine kinase; Provisional; Region: PRK04296 710696005607 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 710696005608 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 710696005609 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 710696005610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696005611 Coenzyme A binding pocket [chemical binding]; other site 710696005612 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 710696005613 CoA binding domain; Region: CoA_binding_2; pfam13380 710696005614 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 710696005615 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 710696005616 Nitroreductase family; Region: Nitroreductase; pfam00881 710696005617 FMN binding site [chemical binding]; other site 710696005618 dimer interface [polypeptide binding]; other site 710696005619 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 710696005620 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 710696005621 CAP-like domain; other site 710696005622 active site 710696005623 primary dimer interface [polypeptide binding]; other site 710696005624 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710696005625 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 710696005626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696005627 ATP binding site [chemical binding]; other site 710696005628 Mg2+ binding site [ion binding]; other site 710696005629 G-X-G motif; other site 710696005630 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 710696005631 anchoring element; other site 710696005632 dimer interface [polypeptide binding]; other site 710696005633 ATP binding site [chemical binding]; other site 710696005634 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 710696005635 active site 710696005636 putative metal-binding site [ion binding]; other site 710696005637 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 710696005638 Protein of unknown function (DUF456); Region: DUF456; pfam04306 710696005639 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 710696005640 active site 710696005641 DNA polymerase IV; Validated; Region: PRK02406 710696005642 DNA binding site [nucleotide binding] 710696005643 Methyltransferase domain; Region: Methyltransf_11; pfam08241 710696005644 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 710696005645 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 710696005646 active site 710696005647 PHP Thumb interface [polypeptide binding]; other site 710696005648 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 710696005649 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 710696005650 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 710696005651 generic binding surface I; other site 710696005652 generic binding surface II; other site 710696005653 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 710696005654 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 710696005655 putative deacylase active site [active] 710696005656 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 710696005657 FAD binding site [chemical binding]; other site 710696005658 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 710696005659 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 710696005660 substrate binding pocket [chemical binding]; other site 710696005661 chain length determination region; other site 710696005662 substrate-Mg2+ binding site; other site 710696005663 catalytic residues [active] 710696005664 aspartate-rich region 1; other site 710696005665 active site lid residues [active] 710696005666 aspartate-rich region 2; other site 710696005667 Helix-turn-helix domain; Region: HTH_17; cl17695 710696005668 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 710696005669 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 710696005670 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 710696005671 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 710696005672 N-acetyl-D-glucosamine binding site [chemical binding]; other site 710696005673 catalytic residue [active] 710696005674 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710696005675 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710696005676 active site 710696005677 ATP binding site [chemical binding]; other site 710696005678 substrate binding site [chemical binding]; other site 710696005679 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710696005680 substrate binding site [chemical binding]; other site 710696005681 activation loop (A-loop); other site 710696005682 activation loop (A-loop); other site 710696005683 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710696005684 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710696005685 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710696005686 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 710696005687 EamA-like transporter family; Region: EamA; pfam00892 710696005688 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 710696005689 EamA-like transporter family; Region: EamA; pfam00892 710696005690 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710696005691 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 710696005692 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710696005693 catalytic residue [active] 710696005694 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 710696005695 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710696005696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696005697 active site 710696005698 phosphorylation site [posttranslational modification] 710696005699 intermolecular recognition site; other site 710696005700 dimerization interface [polypeptide binding]; other site 710696005701 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710696005702 DNA binding residues [nucleotide binding] 710696005703 dimerization interface [polypeptide binding]; other site 710696005704 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 710696005705 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710696005706 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710696005707 putative acyl-acceptor binding pocket; other site 710696005708 putative catalytic site [active] 710696005709 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 710696005710 putative metal binding site [ion binding]; other site 710696005711 putative phosphate binding site [ion binding]; other site 710696005712 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 710696005713 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 710696005714 nucleotide binding site [chemical binding]; other site 710696005715 Glucokinase; Region: Glucokinase; cl17310 710696005716 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 710696005717 putative hydrophobic ligand binding site [chemical binding]; other site 710696005718 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 710696005719 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 710696005720 acyl-activating enzyme (AAE) consensus motif; other site 710696005721 putative AMP binding site [chemical binding]; other site 710696005722 putative active site [active] 710696005723 putative CoA binding site [chemical binding]; other site 710696005724 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 710696005725 hypothetical protein; Validated; Region: PRK07883 710696005726 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 710696005727 active site 710696005728 catalytic site [active] 710696005729 substrate binding site [chemical binding]; other site 710696005730 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 710696005731 GIY-YIG motif/motif A; other site 710696005732 active site 710696005733 catalytic site [active] 710696005734 putative DNA binding site [nucleotide binding]; other site 710696005735 metal binding site [ion binding]; metal-binding site 710696005736 UvrB/uvrC motif; Region: UVR; pfam02151 710696005737 AsnC family; Region: AsnC_trans_reg; pfam01037 710696005738 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 710696005739 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 710696005740 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 710696005741 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 710696005742 Response regulator receiver domain; Region: Response_reg; pfam00072 710696005743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696005744 active site 710696005745 phosphorylation site [posttranslational modification] 710696005746 intermolecular recognition site; other site 710696005747 dimerization interface [polypeptide binding]; other site 710696005748 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 710696005749 Subunit I/III interface [polypeptide binding]; other site 710696005750 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 710696005751 Cytochrome c; Region: Cytochrom_C; pfam00034 710696005752 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 710696005753 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 710696005754 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 710696005755 iron-sulfur cluster [ion binding]; other site 710696005756 [2Fe-2S] cluster binding site [ion binding]; other site 710696005757 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 710696005758 heme bH binding site [chemical binding]; other site 710696005759 Qi binding site; other site 710696005760 intrachain domain interface; other site 710696005761 heme bL binding site [chemical binding]; other site 710696005762 interchain domain interface [polypeptide binding]; other site 710696005763 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 710696005764 Qo binding site; other site 710696005765 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 710696005766 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 710696005767 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 710696005768 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 710696005769 D-pathway; other site 710696005770 Putative ubiquinol binding site [chemical binding]; other site 710696005771 Low-spin heme (heme b) binding site [chemical binding]; other site 710696005772 Putative water exit pathway; other site 710696005773 Binuclear center (heme o3/CuB) [ion binding]; other site 710696005774 K-pathway; other site 710696005775 Putative proton exit pathway; other site 710696005776 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 710696005777 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 710696005778 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710696005779 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 710696005780 CPxP motif; other site 710696005781 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 710696005782 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 710696005783 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710696005784 substrate binding site [chemical binding]; other site 710696005785 ATP binding site [chemical binding]; other site 710696005786 Predicted transcriptional regulator [Transcription]; Region: COG2345 710696005787 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696005788 putative DNA binding site [nucleotide binding]; other site 710696005789 putative Zn2+ binding site [ion binding]; other site 710696005790 V4R domain; Region: V4R; cl15268 710696005791 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710696005792 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 710696005793 Ferredoxin [Energy production and conversion]; Region: COG1146 710696005794 4Fe-4S binding domain; Region: Fer4; pfam00037 710696005795 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 710696005796 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 710696005797 quinolinate synthetase; Provisional; Region: PRK09375 710696005798 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 710696005799 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 710696005800 active site 710696005801 metal binding site [ion binding]; metal-binding site 710696005802 hypothetical protein; Provisional; Region: PRK07907 710696005803 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 710696005804 active site 710696005805 metal binding site [ion binding]; metal-binding site 710696005806 dimer interface [polypeptide binding]; other site 710696005807 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13944 710696005808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696005809 S-adenosylmethionine binding site [chemical binding]; other site 710696005810 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 710696005811 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 710696005812 Beta-lactamase; Region: Beta-lactamase; pfam00144 710696005813 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710696005814 Cobalt transport protein; Region: CbiQ; cl00463 710696005815 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710696005816 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 710696005817 Walker A/P-loop; other site 710696005818 ATP binding site [chemical binding]; other site 710696005819 Q-loop/lid; other site 710696005820 ABC transporter signature motif; other site 710696005821 Walker B; other site 710696005822 D-loop; other site 710696005823 H-loop/switch region; other site 710696005824 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696005825 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710696005826 Walker A/P-loop; other site 710696005827 ATP binding site [chemical binding]; other site 710696005828 Q-loop/lid; other site 710696005829 ABC transporter signature motif; other site 710696005830 Walker B; other site 710696005831 D-loop; other site 710696005832 H-loop/switch region; other site 710696005833 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 710696005834 homotrimer interface [polypeptide binding]; other site 710696005835 Walker A motif; other site 710696005836 GTP binding site [chemical binding]; other site 710696005837 Walker B motif; other site 710696005838 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 710696005839 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 710696005840 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 710696005841 multifunctional aminopeptidase A; Provisional; Region: PRK00913 710696005842 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 710696005843 interface (dimer of trimers) [polypeptide binding]; other site 710696005844 Substrate-binding/catalytic site; other site 710696005845 Zn-binding sites [ion binding]; other site 710696005846 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 710696005847 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 710696005848 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710696005849 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710696005850 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710696005851 E3 interaction surface; other site 710696005852 lipoyl attachment site [posttranslational modification]; other site 710696005853 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710696005854 E3 interaction surface; other site 710696005855 lipoyl attachment site [posttranslational modification]; other site 710696005856 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 710696005857 e3 binding domain; Region: E3_binding; pfam02817 710696005858 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 710696005859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696005860 TIGR01777 family protein; Region: yfcH 710696005861 NAD(P) binding site [chemical binding]; other site 710696005862 active site 710696005863 Protein kinase domain; Region: Pkinase; pfam00069 710696005864 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710696005865 active site 710696005866 ATP binding site [chemical binding]; other site 710696005867 substrate binding site [chemical binding]; other site 710696005868 activation loop (A-loop); other site 710696005869 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710696005870 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710696005871 lipoate-protein ligase B; Provisional; Region: PRK14345 710696005872 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 710696005873 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 710696005874 Walker A/P-loop; other site 710696005875 ATP binding site [chemical binding]; other site 710696005876 Q-loop/lid; other site 710696005877 ABC transporter signature motif; other site 710696005878 Walker B; other site 710696005879 D-loop; other site 710696005880 H-loop/switch region; other site 710696005881 lipoyl synthase; Provisional; Region: PRK05481 710696005882 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710696005883 FeS/SAM binding site; other site 710696005884 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 710696005885 RDD family; Region: RDD; pfam06271 710696005886 glutamine synthetase, type I; Region: GlnA; TIGR00653 710696005887 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 710696005888 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710696005889 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 710696005890 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 710696005891 metal binding triad; other site 710696005892 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 710696005893 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 710696005894 metal binding triad; other site 710696005895 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 710696005896 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 710696005897 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710696005898 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 710696005899 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 710696005900 oligomerization interface [polypeptide binding]; other site 710696005901 active site 710696005902 metal binding site [ion binding]; metal-binding site 710696005903 methionine aminopeptidase; Provisional; Region: PRK12318 710696005904 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 710696005905 active site 710696005906 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 710696005907 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 710696005908 nucleotide binding site [chemical binding]; other site 710696005909 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 710696005910 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710696005911 Walker A/P-loop; other site 710696005912 ATP binding site [chemical binding]; other site 710696005913 Q-loop/lid; other site 710696005914 ABC transporter signature motif; other site 710696005915 Walker B; other site 710696005916 D-loop; other site 710696005917 H-loop/switch region; other site 710696005918 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 710696005919 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 710696005920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696005921 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710696005922 putative substrate translocation pore; other site 710696005923 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710696005924 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 710696005925 hypothetical protein; Validated; Region: PRK07586 710696005926 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710696005927 PYR/PP interface [polypeptide binding]; other site 710696005928 dimer interface [polypeptide binding]; other site 710696005929 TPP binding site [chemical binding]; other site 710696005930 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 710696005931 TPP-binding site [chemical binding]; other site 710696005932 dimer interface [polypeptide binding]; other site 710696005933 RNB domain; Region: RNB; pfam00773 710696005934 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 710696005935 hypothetical protein; Validated; Region: PRK02101 710696005936 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 710696005937 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 710696005938 homodimer interface [polypeptide binding]; other site 710696005939 substrate-cofactor binding pocket; other site 710696005940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696005941 catalytic residue [active] 710696005942 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 710696005943 active site residue [active] 710696005944 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 710696005945 RNA/DNA hybrid binding site [nucleotide binding]; other site 710696005946 active site 710696005947 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 710696005948 Putative zinc ribbon domain; Region: DUF164; pfam02591 710696005949 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 710696005950 Uncharacterized conserved protein [Function unknown]; Region: COG0327 710696005951 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 710696005952 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710696005953 phosphate binding site [ion binding]; other site 710696005954 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 710696005955 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 710696005956 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710696005957 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 710696005958 TM-ABC transporter signature motif; other site 710696005959 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 710696005960 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 710696005961 TM-ABC transporter signature motif; other site 710696005962 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 710696005963 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 710696005964 Walker A/P-loop; other site 710696005965 ATP binding site [chemical binding]; other site 710696005966 Q-loop/lid; other site 710696005967 ABC transporter signature motif; other site 710696005968 Walker B; other site 710696005969 D-loop; other site 710696005970 H-loop/switch region; other site 710696005971 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 710696005972 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 710696005973 Walker A/P-loop; other site 710696005974 ATP binding site [chemical binding]; other site 710696005975 Q-loop/lid; other site 710696005976 ABC transporter signature motif; other site 710696005977 Walker B; other site 710696005978 D-loop; other site 710696005979 H-loop/switch region; other site 710696005980 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 710696005981 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 710696005982 dimer interface [polypeptide binding]; other site 710696005983 catalytic triad [active] 710696005984 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 710696005985 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 710696005986 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 710696005987 dimer interface [polypeptide binding]; other site 710696005988 TPP-binding site [chemical binding]; other site 710696005989 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 710696005990 argininosuccinate synthase; Validated; Region: PRK05370 710696005991 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710696005992 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 710696005993 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 710696005994 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 710696005995 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 710696005996 dimer interface [polypeptide binding]; other site 710696005997 active site 710696005998 CoA binding pocket [chemical binding]; other site 710696005999 acyl carrier protein; Provisional; Region: acpP; PRK00982 710696006000 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 710696006001 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 710696006002 dimer interface [polypeptide binding]; other site 710696006003 active site 710696006004 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 710696006005 hypothetical protein; Reviewed; Region: PRK09588 710696006006 Transcription factor WhiB; Region: Whib; pfam02467 710696006007 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 710696006008 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710696006009 active site 710696006010 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 710696006011 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 710696006012 [2Fe-2S] cluster binding site [ion binding]; other site 710696006013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696006014 dimerization interface [polypeptide binding]; other site 710696006015 putative DNA binding site [nucleotide binding]; other site 710696006016 putative Zn2+ binding site [ion binding]; other site 710696006017 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 710696006018 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710696006019 active site residue [active] 710696006020 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710696006021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696006022 putative substrate translocation pore; other site 710696006023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696006024 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 710696006025 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 710696006026 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; cl01757 710696006027 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696006028 dimerization interface [polypeptide binding]; other site 710696006029 putative DNA binding site [nucleotide binding]; other site 710696006030 putative Zn2+ binding site [ion binding]; other site 710696006031 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 710696006032 arsenical-resistance protein; Region: acr3; TIGR00832 710696006033 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 710696006034 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 710696006035 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 710696006036 DTAP/Switch II; other site 710696006037 Switch I; other site 710696006038 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 710696006039 DTAP/Switch II; other site 710696006040 Switch I; other site 710696006041 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 710696006042 Low molecular weight phosphatase family; Region: LMWPc; cd00115 710696006043 active site 710696006044 Bacterial Ig-like domain; Region: Big_5; pfam13205 710696006045 Bacterial Ig-like domain; Region: Big_5; pfam13205 710696006046 Bacterial Ig-like domain; Region: Big_5; pfam13205 710696006047 Bacterial Ig-like domain; Region: Big_5; pfam13205 710696006048 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 710696006049 Ca2+ binding site [ion binding]; other site 710696006050 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 710696006051 Ca2+ binding site [ion binding]; other site 710696006052 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 710696006053 Phage Tail Collar Domain; Region: Collar; pfam07484 710696006054 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 710696006055 Phage Tail Collar Domain; Region: Collar; pfam07484 710696006056 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 710696006057 Phage Tail Collar Domain; Region: Collar; pfam07484 710696006058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696006059 Coenzyme A binding pocket [chemical binding]; other site 710696006060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710696006061 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710696006062 D-xylulose kinase; Region: XylB; TIGR01312 710696006063 nucleotide binding site [chemical binding]; other site 710696006064 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 710696006065 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 710696006066 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 710696006067 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710696006068 classical (c) SDRs; Region: SDR_c; cd05233 710696006069 NAD(P) binding site [chemical binding]; other site 710696006070 active site 710696006071 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710696006072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696006073 dimer interface [polypeptide binding]; other site 710696006074 conserved gate region; other site 710696006075 ABC-ATPase subunit interface; other site 710696006076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696006077 dimer interface [polypeptide binding]; other site 710696006078 conserved gate region; other site 710696006079 ABC-ATPase subunit interface; other site 710696006080 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 710696006081 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 710696006082 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 710696006083 Helix-turn-helix domain; Region: HTH_18; pfam12833 710696006084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710696006085 Short C-terminal domain; Region: SHOCT; pfam09851 710696006086 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 710696006087 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 710696006088 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 710696006089 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 710696006090 dimerization interface [polypeptide binding]; other site 710696006091 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 710696006092 4Fe-4S binding domain; Region: Fer4_5; pfam12801 710696006093 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 710696006094 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 710696006095 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 710696006096 putative dimer interface [polypeptide binding]; other site 710696006097 putative active site [active] 710696006098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696006099 Walker A/P-loop; other site 710696006100 ATP binding site [chemical binding]; other site 710696006101 Q-loop/lid; other site 710696006102 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 710696006103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696006104 Walker A/P-loop; other site 710696006105 ATP binding site [chemical binding]; other site 710696006106 Q-loop/lid; other site 710696006107 ABC transporter; Region: ABC_tran; pfam00005 710696006108 ABC transporter signature motif; other site 710696006109 Walker B; other site 710696006110 D-loop; other site 710696006111 H-loop/switch region; other site 710696006112 NnrS protein; Region: NnrS; pfam05940 710696006113 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 710696006114 Peptidase family M23; Region: Peptidase_M23; pfam01551 710696006115 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 710696006116 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 710696006117 Walker A/P-loop; other site 710696006118 ATP binding site [chemical binding]; other site 710696006119 Q-loop/lid; other site 710696006120 ABC transporter signature motif; other site 710696006121 Walker B; other site 710696006122 D-loop; other site 710696006123 H-loop/switch region; other site 710696006124 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710696006125 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710696006126 substrate binding pocket [chemical binding]; other site 710696006127 membrane-bound complex binding site; other site 710696006128 hinge residues; other site 710696006129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696006130 dimer interface [polypeptide binding]; other site 710696006131 conserved gate region; other site 710696006132 putative PBP binding loops; other site 710696006133 ABC-ATPase subunit interface; other site 710696006134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696006135 dimer interface [polypeptide binding]; other site 710696006136 conserved gate region; other site 710696006137 putative PBP binding loops; other site 710696006138 ABC-ATPase subunit interface; other site 710696006139 DNA primase, catalytic core; Region: dnaG; TIGR01391 710696006140 CHC2 zinc finger; Region: zf-CHC2; pfam01807 710696006141 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 710696006142 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 710696006143 active site 710696006144 metal binding site [ion binding]; metal-binding site 710696006145 interdomain interaction site; other site 710696006146 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 710696006147 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 710696006148 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710696006149 Zn2+ binding site [ion binding]; other site 710696006150 Mg2+ binding site [ion binding]; other site 710696006151 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 710696006152 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 710696006153 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 710696006154 FMN binding site [chemical binding]; other site 710696006155 active site 710696006156 catalytic residues [active] 710696006157 substrate binding site [chemical binding]; other site 710696006158 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 710696006159 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710696006160 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 710696006161 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 710696006162 active site residue [active] 710696006163 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 710696006164 active site residue [active] 710696006165 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 710696006166 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 710696006167 intersubunit interface [polypeptide binding]; other site 710696006168 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710696006169 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 710696006170 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 710696006171 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 710696006172 ABC-ATPase subunit interface; other site 710696006173 dimer interface [polypeptide binding]; other site 710696006174 putative PBP binding regions; other site 710696006175 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 710696006176 metal binding site 2 [ion binding]; metal-binding site 710696006177 putative DNA binding helix; other site 710696006178 metal binding site 1 [ion binding]; metal-binding site 710696006179 dimer interface [polypeptide binding]; other site 710696006180 structural Zn2+ binding site [ion binding]; other site 710696006181 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 710696006182 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 710696006183 catalytic residue [active] 710696006184 putative FPP diphosphate binding site; other site 710696006185 putative FPP binding hydrophobic cleft; other site 710696006186 dimer interface [polypeptide binding]; other site 710696006187 putative IPP diphosphate binding site; other site 710696006188 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 710696006189 Recombination protein O N terminal; Region: RecO_N; pfam11967 710696006190 Recombination protein O C terminal; Region: RecO_C; pfam02565 710696006191 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 710696006192 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710696006193 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710696006194 Predicted flavoprotein [General function prediction only]; Region: COG0431 710696006195 conserved hypothetical integral membrane protein; Region: TIGR03766 710696006196 conserved hypothetical integral membrane protein; Region: TIGR03766 710696006197 2-isopropylmalate synthase; Validated; Region: PRK03739 710696006198 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 710696006199 active site 710696006200 catalytic residues [active] 710696006201 metal binding site [ion binding]; metal-binding site 710696006202 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 710696006203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710696006204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710696006205 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 710696006206 dimerization interface [polypeptide binding]; other site 710696006207 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 710696006208 GTPase Era; Reviewed; Region: era; PRK00089 710696006209 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 710696006210 G1 box; other site 710696006211 GTP/Mg2+ binding site [chemical binding]; other site 710696006212 Switch I region; other site 710696006213 G2 box; other site 710696006214 Switch II region; other site 710696006215 G3 box; other site 710696006216 G4 box; other site 710696006217 G5 box; other site 710696006218 KH domain; Region: KH_2; pfam07650 710696006219 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 710696006220 Domain of unknown function DUF21; Region: DUF21; pfam01595 710696006221 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 710696006222 Transporter associated domain; Region: CorC_HlyC; smart01091 710696006223 metal-binding heat shock protein; Provisional; Region: PRK00016 710696006224 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 710696006225 PhoH-like protein; Region: PhoH; pfam02562 710696006226 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 710696006227 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 710696006228 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 710696006229 nucleotide binding site/active site [active] 710696006230 HIT family signature motif; other site 710696006231 catalytic residue [active] 710696006232 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710696006233 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696006234 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710696006235 DNA binding residues [nucleotide binding] 710696006236 Sporulation and spore germination; Region: Germane; pfam10646 710696006237 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 710696006238 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 710696006239 chaperone protein DnaJ; Provisional; Region: PRK14278 710696006240 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 710696006241 HSP70 interaction site [polypeptide binding]; other site 710696006242 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 710696006243 Zn binding sites [ion binding]; other site 710696006244 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 710696006245 dimer interface [polypeptide binding]; other site 710696006246 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 710696006247 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 710696006248 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 710696006249 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 710696006250 NAD(P) binding site [chemical binding]; other site 710696006251 catalytic residues [active] 710696006252 coproporphyrinogen III oxidase; Validated; Region: PRK05628 710696006253 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710696006254 FeS/SAM binding site; other site 710696006255 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 710696006256 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 710696006257 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 710696006258 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 710696006259 GTP-binding protein LepA; Provisional; Region: PRK05433 710696006260 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 710696006261 G1 box; other site 710696006262 putative GEF interaction site [polypeptide binding]; other site 710696006263 GTP/Mg2+ binding site [chemical binding]; other site 710696006264 Switch I region; other site 710696006265 G2 box; other site 710696006266 G3 box; other site 710696006267 Switch II region; other site 710696006268 G4 box; other site 710696006269 G5 box; other site 710696006270 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 710696006271 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 710696006272 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 710696006273 Cupin domain; Region: Cupin_2; cl17218 710696006274 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 710696006275 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 710696006276 Walker A/P-loop; other site 710696006277 ATP binding site [chemical binding]; other site 710696006278 Q-loop/lid; other site 710696006279 ABC transporter signature motif; other site 710696006280 Walker B; other site 710696006281 D-loop; other site 710696006282 H-loop/switch region; other site 710696006283 TOBE domain; Region: TOBE_2; pfam08402 710696006284 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 710696006285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696006286 dimer interface [polypeptide binding]; other site 710696006287 conserved gate region; other site 710696006288 putative PBP binding loops; other site 710696006289 ABC-ATPase subunit interface; other site 710696006290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696006291 dimer interface [polypeptide binding]; other site 710696006292 conserved gate region; other site 710696006293 putative PBP binding loops; other site 710696006294 ABC-ATPase subunit interface; other site 710696006295 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 710696006296 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 710696006297 PemK-like protein; Region: PemK; pfam02452 710696006298 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 710696006299 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 710696006300 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 710696006301 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 710696006302 ATP binding site [chemical binding]; other site 710696006303 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 710696006304 putative Mg++ binding site [ion binding]; other site 710696006305 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 710696006306 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 710696006307 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 710696006308 Potassium binding sites [ion binding]; other site 710696006309 Cesium cation binding sites [ion binding]; other site 710696006310 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 710696006311 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 710696006312 HflX GTPase family; Region: HflX; cd01878 710696006313 G1 box; other site 710696006314 GTP/Mg2+ binding site [chemical binding]; other site 710696006315 Switch I region; other site 710696006316 G2 box; other site 710696006317 G3 box; other site 710696006318 Switch II region; other site 710696006319 G4 box; other site 710696006320 G5 box; other site 710696006321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696006322 S-adenosylmethionine binding site [chemical binding]; other site 710696006323 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 710696006324 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710696006325 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710696006326 catalytic residue [active] 710696006327 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 710696006328 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 710696006329 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 710696006330 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 710696006331 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 710696006332 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 710696006333 active site 710696006334 catalytic residues [active] 710696006335 metal binding site [ion binding]; metal-binding site 710696006336 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 710696006337 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 710696006338 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710696006339 FeS/SAM binding site; other site 710696006340 Uncharacterized conserved protein [Function unknown]; Region: COG2353 710696006341 recombination regulator RecX; Reviewed; Region: recX; PRK00117 710696006342 recombinase A; Provisional; Region: recA; PRK09354 710696006343 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 710696006344 hexamer interface [polypeptide binding]; other site 710696006345 Walker A motif; other site 710696006346 ATP binding site [chemical binding]; other site 710696006347 Walker B motif; other site 710696006348 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 710696006349 putative ADP-ribose binding site [chemical binding]; other site 710696006350 putative active site [active] 710696006351 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 710696006352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710696006353 non-specific DNA binding site [nucleotide binding]; other site 710696006354 salt bridge; other site 710696006355 sequence-specific DNA binding site [nucleotide binding]; other site 710696006356 Competence-damaged protein; Region: CinA; pfam02464 710696006357 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 710696006358 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 710696006359 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 710696006360 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710696006361 FeS/SAM binding site; other site 710696006362 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 710696006363 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 710696006364 active site 710696006365 dimer interface [polypeptide binding]; other site 710696006366 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 710696006367 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 710696006368 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710696006369 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 710696006370 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 710696006371 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710696006372 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710696006373 catalytic residue [active] 710696006374 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 710696006375 putative catalytic site [active] 710696006376 putative phosphate binding site [ion binding]; other site 710696006377 putative metal binding site [ion binding]; other site 710696006378 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 710696006379 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710696006380 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 710696006381 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 710696006382 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 710696006383 dimer interface [polypeptide binding]; other site 710696006384 active site 710696006385 catalytic residue [active] 710696006386 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 710696006387 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 710696006388 folate binding site [chemical binding]; other site 710696006389 NADP+ binding site [chemical binding]; other site 710696006390 thymidylate synthase; Reviewed; Region: thyA; PRK01827 710696006391 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 710696006392 dimerization interface [polypeptide binding]; other site 710696006393 active site 710696006394 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 710696006395 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 710696006396 FAD binding pocket [chemical binding]; other site 710696006397 FAD binding motif [chemical binding]; other site 710696006398 phosphate binding motif [ion binding]; other site 710696006399 beta-alpha-beta structure motif; other site 710696006400 NAD(p) ribose binding residues [chemical binding]; other site 710696006401 NAD binding pocket [chemical binding]; other site 710696006402 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 710696006403 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710696006404 catalytic loop [active] 710696006405 iron binding site [ion binding]; other site 710696006406 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 710696006407 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 710696006408 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 710696006409 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 710696006410 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 710696006411 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 710696006412 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 710696006413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696006414 Coenzyme A binding pocket [chemical binding]; other site 710696006415 AzlC protein; Region: AzlC; pfam03591 710696006416 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 710696006417 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710696006418 dihydrodipicolinate reductase; Provisional; Region: PRK00048 710696006419 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710696006420 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 710696006421 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 710696006422 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 710696006423 oligomer interface [polypeptide binding]; other site 710696006424 RNA binding site [nucleotide binding]; other site 710696006425 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 710696006426 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 710696006427 RNase E interface [polypeptide binding]; other site 710696006428 trimer interface [polypeptide binding]; other site 710696006429 active site 710696006430 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 710696006431 putative nucleic acid binding region [nucleotide binding]; other site 710696006432 G-X-X-G motif; other site 710696006433 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 710696006434 RNA binding site [nucleotide binding]; other site 710696006435 domain interface; other site 710696006436 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 710696006437 16S/18S rRNA binding site [nucleotide binding]; other site 710696006438 S13e-L30e interaction site [polypeptide binding]; other site 710696006439 25S rRNA binding site [nucleotide binding]; other site 710696006440 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 710696006441 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710696006442 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710696006443 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 710696006444 SLBB domain; Region: SLBB; pfam10531 710696006445 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 710696006446 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710696006447 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 710696006448 catalytic loop [active] 710696006449 iron binding site [ion binding]; other site 710696006450 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 710696006451 4Fe-4S binding domain; Region: Fer4; pfam00037 710696006452 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 710696006453 [4Fe-4S] binding site [ion binding]; other site 710696006454 molybdopterin cofactor binding site; other site 710696006455 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 710696006456 molybdopterin cofactor binding site; other site 710696006457 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 710696006458 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 710696006459 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710696006460 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710696006461 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710696006462 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 710696006463 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 710696006464 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 710696006465 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 710696006466 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 710696006467 rod shape-determining protein MreC; Region: MreC; pfam04085 710696006468 rod shape-determining protein MreB; Provisional; Region: PRK13927 710696006469 MreB and similar proteins; Region: MreB_like; cd10225 710696006470 nucleotide binding site [chemical binding]; other site 710696006471 Mg binding site [ion binding]; other site 710696006472 putative protofilament interaction site [polypeptide binding]; other site 710696006473 RodZ interaction site [polypeptide binding]; other site 710696006474 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 710696006475 active site 710696006476 multimer interface [polypeptide binding]; other site 710696006477 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 710696006478 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 710696006479 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 710696006480 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710696006481 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 710696006482 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 710696006483 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696006484 Coenzyme A binding pocket [chemical binding]; other site 710696006485 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 710696006486 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 710696006487 HIGH motif; other site 710696006488 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 710696006489 active site 710696006490 KMSKS motif; other site 710696006491 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 710696006492 tRNA binding surface [nucleotide binding]; other site 710696006493 anticodon binding site; other site 710696006494 FAD binding domain; Region: FAD_binding_4; pfam01565 710696006495 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 710696006496 Cna protein B-type domain; Region: Cna_B; pfam05738 710696006497 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 710696006498 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 710696006499 B12 binding site [chemical binding]; other site 710696006500 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710696006501 FeS/SAM binding site; other site 710696006502 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 710696006503 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 710696006504 acyl-activating enzyme (AAE) consensus motif; other site 710696006505 putative AMP binding site [chemical binding]; other site 710696006506 putative active site [active] 710696006507 putative CoA binding site [chemical binding]; other site 710696006508 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 710696006509 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 710696006510 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 710696006511 active site 710696006512 Riboflavin kinase; Region: Flavokinase; pfam01687 710696006513 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 710696006514 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 710696006515 RNA binding site [nucleotide binding]; other site 710696006516 active site 710696006517 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 710696006518 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 710696006519 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 710696006520 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 710696006521 translation initiation factor IF-2; Region: IF-2; TIGR00487 710696006522 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 710696006523 G1 box; other site 710696006524 putative GEF interaction site [polypeptide binding]; other site 710696006525 GTP/Mg2+ binding site [chemical binding]; other site 710696006526 Switch I region; other site 710696006527 G2 box; other site 710696006528 G3 box; other site 710696006529 Switch II region; other site 710696006530 G4 box; other site 710696006531 G5 box; other site 710696006532 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 710696006533 Translation-initiation factor 2; Region: IF-2; pfam11987 710696006534 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 710696006535 Protein of unknown function (DUF448); Region: DUF448; pfam04296 710696006536 putative RNA binding cleft [nucleotide binding]; other site 710696006537 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 710696006538 NusA N-terminal domain; Region: NusA_N; pfam08529 710696006539 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 710696006540 RNA binding site [nucleotide binding]; other site 710696006541 homodimer interface [polypeptide binding]; other site 710696006542 NusA-like KH domain; Region: KH_5; pfam13184 710696006543 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 710696006544 G-X-X-G motif; other site 710696006545 ribosome maturation protein RimP; Reviewed; Region: PRK00092 710696006546 Sm and related proteins; Region: Sm_like; cl00259 710696006547 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 710696006548 putative oligomer interface [polypeptide binding]; other site 710696006549 putative RNA binding site [nucleotide binding]; other site 710696006550 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 710696006551 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 710696006552 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 710696006553 catalytic residues [active] 710696006554 ApbE family; Region: ApbE; pfam02424 710696006555 FMN-binding domain; Region: FMN_bind; cl01081 710696006556 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 710696006557 FAD binding pocket [chemical binding]; other site 710696006558 FAD binding motif [chemical binding]; other site 710696006559 phosphate binding motif [ion binding]; other site 710696006560 beta-alpha-beta structure motif; other site 710696006561 NAD binding pocket [chemical binding]; other site 710696006562 hypothetical protein; Provisional; Region: PRK10621 710696006563 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 710696006564 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 710696006565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710696006566 motif II; other site 710696006567 prolyl-tRNA synthetase; Provisional; Region: PRK09194 710696006568 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 710696006569 dimer interface [polypeptide binding]; other site 710696006570 motif 1; other site 710696006571 active site 710696006572 motif 2; other site 710696006573 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 710696006574 putative deacylase active site [active] 710696006575 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710696006576 active site 710696006577 motif 3; other site 710696006578 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 710696006579 anticodon binding site; other site 710696006580 Predicted acetyltransferase [General function prediction only]; Region: COG3393 710696006581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710696006582 Predicted membrane protein [Function unknown]; Region: COG4270 710696006583 Predicted acetyltransferase [General function prediction only]; Region: COG3393 710696006584 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 710696006585 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710696006586 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 710696006587 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 710696006588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 710696006589 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 710696006590 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 710696006591 active site 710696006592 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 710696006593 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 710696006594 putative substrate binding region [chemical binding]; other site 710696006595 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 710696006596 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 710696006597 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 710696006598 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 710696006599 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 710696006600 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 710696006601 active site 710696006602 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 710696006603 putative RNAase interaction site [polypeptide binding]; other site 710696006604 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 710696006605 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 710696006606 Walker A motif; other site 710696006607 ATP binding site [chemical binding]; other site 710696006608 Walker B motif; other site 710696006609 succinic semialdehyde dehydrogenase; Region: PLN02278 710696006610 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 710696006611 tetramerization interface [polypeptide binding]; other site 710696006612 NAD(P) binding site [chemical binding]; other site 710696006613 catalytic residues [active] 710696006614 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 710696006615 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 710696006616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696006617 dimer interface [polypeptide binding]; other site 710696006618 conserved gate region; other site 710696006619 putative PBP binding loops; other site 710696006620 ABC-ATPase subunit interface; other site 710696006621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696006622 dimer interface [polypeptide binding]; other site 710696006623 conserved gate region; other site 710696006624 putative PBP binding loops; other site 710696006625 ABC-ATPase subunit interface; other site 710696006626 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 710696006627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696006628 Walker A/P-loop; other site 710696006629 ATP binding site [chemical binding]; other site 710696006630 Q-loop/lid; other site 710696006631 ABC transporter signature motif; other site 710696006632 Walker B; other site 710696006633 D-loop; other site 710696006634 H-loop/switch region; other site 710696006635 TOBE domain; Region: TOBE_2; pfam08402 710696006636 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 710696006637 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710696006638 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 710696006639 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 710696006640 tetrameric interface [polypeptide binding]; other site 710696006641 NAD binding site [chemical binding]; other site 710696006642 catalytic residues [active] 710696006643 substrate binding site [chemical binding]; other site 710696006644 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 710696006645 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 710696006646 putative DNA binding site [nucleotide binding]; other site 710696006647 putative Zn2+ binding site [ion binding]; other site 710696006648 AsnC family; Region: AsnC_trans_reg; pfam01037 710696006649 hypothetical protein; Provisional; Region: PRK06541 710696006650 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710696006651 inhibitor-cofactor binding pocket; inhibition site 710696006652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696006653 catalytic residue [active] 710696006654 Predicted permeases [General function prediction only]; Region: COG0679 710696006655 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 710696006656 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 710696006657 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 710696006658 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710696006659 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 710696006660 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710696006661 FeS/SAM binding site; other site 710696006662 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 710696006663 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 710696006664 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710696006665 acyl-activating enzyme (AAE) consensus motif; other site 710696006666 AMP binding site [chemical binding]; other site 710696006667 active site 710696006668 CoA binding site [chemical binding]; other site 710696006669 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 710696006670 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710696006671 FeS/SAM binding site; other site 710696006672 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710696006673 classical (c) SDRs; Region: SDR_c; cd05233 710696006674 NAD(P) binding site [chemical binding]; other site 710696006675 active site 710696006676 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 710696006677 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 710696006678 ribosome recycling factor; Reviewed; Region: frr; PRK00083 710696006679 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 710696006680 hinge region; other site 710696006681 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 710696006682 putative nucleotide binding site [chemical binding]; other site 710696006683 uridine monophosphate binding site [chemical binding]; other site 710696006684 homohexameric interface [polypeptide binding]; other site 710696006685 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 710696006686 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710696006687 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710696006688 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710696006689 dimerization interface [polypeptide binding]; other site 710696006690 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710696006691 dimer interface [polypeptide binding]; other site 710696006692 phosphorylation site [posttranslational modification] 710696006693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696006694 ATP binding site [chemical binding]; other site 710696006695 Mg2+ binding site [ion binding]; other site 710696006696 G-X-G motif; other site 710696006697 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 710696006698 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710696006699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696006700 active site 710696006701 phosphorylation site [posttranslational modification] 710696006702 intermolecular recognition site; other site 710696006703 dimerization interface [polypeptide binding]; other site 710696006704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710696006705 DNA binding site [nucleotide binding] 710696006706 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 710696006707 DsrC like protein; Region: DsrC; pfam04358 710696006708 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 710696006709 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 710696006710 elongation factor Ts; Provisional; Region: tsf; PRK09377 710696006711 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 710696006712 Elongation factor TS; Region: EF_TS; pfam00889 710696006713 Elongation factor TS; Region: EF_TS; pfam00889 710696006714 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 710696006715 rRNA interaction site [nucleotide binding]; other site 710696006716 S8 interaction site; other site 710696006717 putative laminin-1 binding site; other site 710696006718 aminotransferase; Validated; Region: PRK07777 710696006719 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710696006720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696006721 homodimer interface [polypeptide binding]; other site 710696006722 catalytic residue [active] 710696006723 Peptidase family M23; Region: Peptidase_M23; pfam01551 710696006724 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 710696006725 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710696006726 active site 710696006727 DNA binding site [nucleotide binding] 710696006728 Int/Topo IB signature motif; other site 710696006729 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 710696006730 DNA protecting protein DprA; Region: dprA; TIGR00732 710696006731 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 710696006732 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 710696006733 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 710696006734 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 710696006735 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 710696006736 hypothetical protein; Reviewed; Region: PRK12497 710696006737 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 710696006738 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 710696006739 RNA/DNA hybrid binding site [nucleotide binding]; other site 710696006740 active site 710696006741 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 710696006742 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 710696006743 Catalytic site [active] 710696006744 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 710696006745 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 710696006746 Catalytic site [active] 710696006747 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 710696006748 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 710696006749 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 710696006750 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 710696006751 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 710696006752 RimM N-terminal domain; Region: RimM; pfam01782 710696006753 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 710696006754 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 710696006755 G-X-X-G motif; other site 710696006756 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 710696006757 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 710696006758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710696006759 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 710696006760 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710696006761 active site 710696006762 signal recognition particle protein; Provisional; Region: PRK10867 710696006763 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 710696006764 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 710696006765 P loop; other site 710696006766 GTP binding site [chemical binding]; other site 710696006767 Signal peptide binding domain; Region: SRP_SPB; pfam02978 710696006768 [Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693 710696006769 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 710696006770 metal binding triad; other site 710696006771 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 710696006772 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710696006773 Zn2+ binding site [ion binding]; other site 710696006774 Mg2+ binding site [ion binding]; other site 710696006775 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 710696006776 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 710696006777 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 710696006778 Nitrogen regulatory protein P-II; Region: P-II; smart00938 710696006779 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 710696006780 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 710696006781 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 710696006782 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710696006783 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 710696006784 Walker A/P-loop; other site 710696006785 ATP binding site [chemical binding]; other site 710696006786 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 710696006787 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 710696006788 ABC transporter signature motif; other site 710696006789 Walker B; other site 710696006790 D-loop; other site 710696006791 H-loop/switch region; other site 710696006792 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 710696006793 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 710696006794 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 710696006795 chorismate mutase; Provisional; Region: PRK09239 710696006796 Acylphosphatase; Region: Acylphosphatase; cl00551 710696006797 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710696006798 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 710696006799 active site 710696006800 catalytic triad [active] 710696006801 oxyanion hole [active] 710696006802 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 710696006803 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 710696006804 Zn binding site [ion binding]; other site 710696006805 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 710696006806 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 710696006807 active site 710696006808 NAD binding site [chemical binding]; other site 710696006809 metal binding site [ion binding]; metal-binding site 710696006810 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 710696006811 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 710696006812 DNA binding site [nucleotide binding] 710696006813 catalytic residue [active] 710696006814 H2TH interface [polypeptide binding]; other site 710696006815 putative catalytic residues [active] 710696006816 turnover-facilitating residue; other site 710696006817 intercalation triad [nucleotide binding]; other site 710696006818 8OG recognition residue [nucleotide binding]; other site 710696006819 putative reading head residues; other site 710696006820 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710696006821 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710696006822 ribonuclease III; Reviewed; Region: rnc; PRK00102 710696006823 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 710696006824 dimerization interface [polypeptide binding]; other site 710696006825 active site 710696006826 metal binding site [ion binding]; metal-binding site 710696006827 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 710696006828 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 710696006829 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 710696006830 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 710696006831 active site 710696006832 (T/H)XGH motif; other site 710696006833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710696006834 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 710696006835 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 710696006836 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 710696006837 ssDNA binding site; other site 710696006838 generic binding surface II; other site 710696006839 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710696006840 ATP binding site [chemical binding]; other site 710696006841 putative Mg++ binding site [ion binding]; other site 710696006842 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710696006843 nucleotide binding region [chemical binding]; other site 710696006844 ATP-binding site [chemical binding]; other site 710696006845 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 710696006846 DAK2 domain; Region: Dak2; pfam02734 710696006847 Fructosamine kinase; Region: Fructosamin_kin; cl17579 710696006848 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 710696006849 thiamine monophosphate kinase; Provisional; Region: PRK05731 710696006850 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 710696006851 ATP binding site [chemical binding]; other site 710696006852 dimerization interface [polypeptide binding]; other site 710696006853 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 710696006854 AsnC family; Region: AsnC_trans_reg; pfam01037 710696006855 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 710696006856 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 710696006857 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 710696006858 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 710696006859 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 710696006860 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710696006861 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710696006862 catalytic residue [active] 710696006863 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 710696006864 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 710696006865 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 710696006866 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710696006867 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710696006868 putative acyl-acceptor binding pocket; other site 710696006869 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 710696006870 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 710696006871 IHF - DNA interface [nucleotide binding]; other site 710696006872 IHF dimer interface [polypeptide binding]; other site 710696006873 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 710696006874 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 710696006875 substrate binding site [chemical binding]; other site 710696006876 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 710696006877 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 710696006878 substrate binding site [chemical binding]; other site 710696006879 ligand binding site [chemical binding]; other site 710696006880 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 710696006881 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710696006882 Bacterial transcriptional regulator; Region: IclR; pfam01614 710696006883 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 710696006884 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710696006885 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 710696006886 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710696006887 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 710696006888 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710696006889 motif II; other site 710696006890 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 710696006891 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 710696006892 HIGH motif; other site 710696006893 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 710696006894 active site 710696006895 KMSKS motif; other site 710696006896 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 710696006897 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 710696006898 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 710696006899 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696006900 biotin synthase; Validated; Region: PRK06256 710696006901 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710696006902 FeS/SAM binding site; other site 710696006903 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 710696006904 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710696006905 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 710696006906 inhibitor-cofactor binding pocket; inhibition site 710696006907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696006908 catalytic residue [active] 710696006909 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 710696006910 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 710696006911 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710696006912 catalytic residue [active] 710696006913 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 710696006914 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 710696006915 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 710696006916 active site 710696006917 catalytic residues [active] 710696006918 metal binding site [ion binding]; metal-binding site 710696006919 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 710696006920 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 710696006921 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 710696006922 catalytic triad [active] 710696006923 short chain dehydrogenase; Provisional; Region: PRK06057 710696006924 classical (c) SDRs; Region: SDR_c; cd05233 710696006925 NAD(P) binding site [chemical binding]; other site 710696006926 active site 710696006927 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710696006928 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 710696006929 NAD(P) binding site [chemical binding]; other site 710696006930 catalytic residues [active] 710696006931 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 710696006932 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710696006933 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710696006934 DNA-binding site [nucleotide binding]; DNA binding site 710696006935 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710696006936 FCD domain; Region: FCD; pfam07729 710696006937 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 710696006938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710696006939 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 710696006940 active site 710696006941 motif I; other site 710696006942 motif II; other site 710696006943 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 710696006944 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 710696006945 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 710696006946 homodimer interface [polypeptide binding]; other site 710696006947 substrate-cofactor binding pocket; other site 710696006948 catalytic residue [active] 710696006949 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 710696006950 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 710696006951 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 710696006952 ligand binding site [chemical binding]; other site 710696006953 NAD binding site [chemical binding]; other site 710696006954 dimerization interface [polypeptide binding]; other site 710696006955 catalytic site [active] 710696006956 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 710696006957 putative L-serine binding site [chemical binding]; other site 710696006958 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 710696006959 Protein of unknown function (DUF461); Region: DUF461; pfam04314 710696006960 ketol-acid reductoisomerase; Provisional; Region: PRK05479 710696006961 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 710696006962 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 710696006963 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 710696006964 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 710696006965 putative valine binding site [chemical binding]; other site 710696006966 dimer interface [polypeptide binding]; other site 710696006967 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 710696006968 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 710696006969 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710696006970 PYR/PP interface [polypeptide binding]; other site 710696006971 dimer interface [polypeptide binding]; other site 710696006972 TPP binding site [chemical binding]; other site 710696006973 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710696006974 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 710696006975 TPP-binding site [chemical binding]; other site 710696006976 dimer interface [polypeptide binding]; other site 710696006977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710696006978 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 710696006979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696006980 Coenzyme A binding pocket [chemical binding]; other site 710696006981 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 710696006982 6-phosphogluconate dehydratase; Region: edd; TIGR01196 710696006983 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710696006984 catalytic core [active] 710696006985 Ubiquitin-like proteins; Region: UBQ; cl00155 710696006986 charged pocket; other site 710696006987 hydrophobic patch; other site 710696006988 VPS10 domain; Region: VPS10; smart00602 710696006989 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 710696006990 putative ligand binding site [chemical binding]; other site 710696006991 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 710696006992 putative NAD binding site [chemical binding]; other site 710696006993 catalytic site [active] 710696006994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 710696006995 MOSC domain; Region: MOSC; pfam03473 710696006996 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 710696006997 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 710696006998 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 710696006999 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 710696007000 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 710696007001 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 710696007002 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 710696007003 GatB domain; Region: GatB_Yqey; smart00845 710696007004 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 710696007005 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 710696007006 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 710696007007 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 710696007008 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 710696007009 TM-ABC transporter signature motif; other site 710696007010 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 710696007011 TM-ABC transporter signature motif; other site 710696007012 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 710696007013 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 710696007014 putative ligand binding site [chemical binding]; other site 710696007015 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 710696007016 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 710696007017 Walker A/P-loop; other site 710696007018 ATP binding site [chemical binding]; other site 710696007019 Q-loop/lid; other site 710696007020 ABC transporter signature motif; other site 710696007021 Walker B; other site 710696007022 D-loop; other site 710696007023 H-loop/switch region; other site 710696007024 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 710696007025 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 710696007026 Walker A/P-loop; other site 710696007027 ATP binding site [chemical binding]; other site 710696007028 Q-loop/lid; other site 710696007029 ABC transporter signature motif; other site 710696007030 Walker B; other site 710696007031 D-loop; other site 710696007032 H-loop/switch region; other site 710696007033 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 710696007034 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 710696007035 nucleotide binding pocket [chemical binding]; other site 710696007036 K-X-D-G motif; other site 710696007037 catalytic site [active] 710696007038 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 710696007039 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 710696007040 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 710696007041 Dimer interface [polypeptide binding]; other site 710696007042 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 710696007043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710696007044 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710696007045 EamA-like transporter family; Region: EamA; pfam00892 710696007046 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 710696007047 EamA-like transporter family; Region: EamA; pfam00892 710696007048 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710696007049 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710696007050 active site 710696007051 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710696007052 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710696007053 active site 710696007054 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 710696007055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696007056 Coenzyme A binding pocket [chemical binding]; other site 710696007057 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 710696007058 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 710696007059 Ligand Binding Site [chemical binding]; other site 710696007060 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 710696007061 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 710696007062 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710696007063 catalytic residue [active] 710696007064 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 710696007065 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 710696007066 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 710696007067 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 710696007068 Ligand binding site [chemical binding]; other site 710696007069 Electron transfer flavoprotein domain; Region: ETF; pfam01012 710696007070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 710696007071 enoyl-CoA hydratase; Provisional; Region: PRK05862 710696007072 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710696007073 substrate binding site [chemical binding]; other site 710696007074 oxyanion hole (OAH) forming residues; other site 710696007075 trimer interface [polypeptide binding]; other site 710696007076 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 710696007077 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 710696007078 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 710696007079 active site 710696007080 catalytic site [active] 710696007081 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 710696007082 putative homodimer interface [polypeptide binding]; other site 710696007083 putative active site pocket [active] 710696007084 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 710696007085 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 710696007086 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 710696007087 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 710696007088 active site 710696007089 homodimer interface [polypeptide binding]; other site 710696007090 catalytic site [active] 710696007091 acceptor binding site [chemical binding]; other site 710696007092 trehalose synthase; Region: treS_nterm; TIGR02456 710696007093 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 710696007094 active site 710696007095 catalytic site [active] 710696007096 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 710696007097 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 710696007098 glycogen branching enzyme; Provisional; Region: PRK05402 710696007099 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 710696007100 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 710696007101 active site 710696007102 catalytic site [active] 710696007103 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 710696007104 phosphoglucomutase; Validated; Region: PRK07564 710696007105 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 710696007106 active site 710696007107 substrate binding site [chemical binding]; other site 710696007108 metal binding site [ion binding]; metal-binding site 710696007109 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710696007110 active site 710696007111 catalytic residues [active] 710696007112 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710696007113 catalytic residues [active] 710696007114 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 710696007115 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710696007116 Domain of unknown function DUF77; Region: DUF77; pfam01910 710696007117 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 710696007118 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 710696007119 Walker A; other site 710696007120 putative acyltransferase; Provisional; Region: PRK05790 710696007121 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710696007122 dimer interface [polypeptide binding]; other site 710696007123 active site 710696007124 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710696007125 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 710696007126 dimer interface [polypeptide binding]; other site 710696007127 substrate binding site [chemical binding]; other site 710696007128 metal binding site [ion binding]; metal-binding site 710696007129 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 710696007130 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 710696007131 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 710696007132 NodB motif; other site 710696007133 active site 710696007134 catalytic site [active] 710696007135 metal binding site [ion binding]; metal-binding site 710696007136 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 710696007137 Predicted transcriptional regulators [Transcription]; Region: COG1695 710696007138 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 710696007139 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 710696007140 Walker A/P-loop; other site 710696007141 ATP binding site [chemical binding]; other site 710696007142 Q-loop/lid; other site 710696007143 ABC transporter signature motif; other site 710696007144 Walker B; other site 710696007145 D-loop; other site 710696007146 H-loop/switch region; other site 710696007147 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710696007148 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 710696007149 NAD(P) binding site [chemical binding]; other site 710696007150 Domain of unknown function DUF20; Region: UPF0118; pfam01594 710696007151 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 710696007152 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 710696007153 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 710696007154 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 710696007155 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 710696007156 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 710696007157 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 710696007158 hypothetical protein; Provisional; Region: PRK03298 710696007159 Protein of unknown function (DUF554); Region: DUF554; pfam04474 710696007160 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 710696007161 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 710696007162 B12 binding site [chemical binding]; other site 710696007163 cobalt ligand [ion binding]; other site 710696007164 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710696007165 anti sigma factor interaction site; other site 710696007166 regulatory phosphorylation site [posttranslational modification]; other site 710696007167 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 710696007168 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 710696007169 hinge; other site 710696007170 active site 710696007171 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 710696007172 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 710696007173 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 710696007174 gamma subunit interface [polypeptide binding]; other site 710696007175 LBP interface [polypeptide binding]; other site 710696007176 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 710696007177 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710696007178 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 710696007179 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 710696007180 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 710696007181 alpha subunit interaction interface [polypeptide binding]; other site 710696007182 Walker A motif; other site 710696007183 ATP binding site [chemical binding]; other site 710696007184 Walker B motif; other site 710696007185 inhibitor binding site; inhibition site 710696007186 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 710696007187 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 710696007188 core domain interface [polypeptide binding]; other site 710696007189 delta subunit interface [polypeptide binding]; other site 710696007190 epsilon subunit interface [polypeptide binding]; other site 710696007191 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 710696007192 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 710696007193 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 710696007194 beta subunit interaction interface [polypeptide binding]; other site 710696007195 Walker A motif; other site 710696007196 ATP binding site [chemical binding]; other site 710696007197 Walker B motif; other site 710696007198 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 710696007199 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 710696007200 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 710696007201 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 710696007202 ATP synthase subunit C; Region: ATP-synt_C; cl00466 710696007203 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 710696007204 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 710696007205 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 710696007206 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 710696007207 Mg++ binding site [ion binding]; other site 710696007208 putative catalytic motif [active] 710696007209 substrate binding site [chemical binding]; other site 710696007210 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 710696007211 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 710696007212 dimer interface [polypeptide binding]; other site 710696007213 active site 710696007214 glycine-pyridoxal phosphate binding site [chemical binding]; other site 710696007215 folate binding site [chemical binding]; other site 710696007216 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 710696007217 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 710696007218 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710696007219 membrane-bound complex binding site; other site 710696007220 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 710696007221 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 710696007222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696007223 S-adenosylmethionine binding site [chemical binding]; other site 710696007224 peptide chain release factor 1; Validated; Region: prfA; PRK00591 710696007225 This domain is found in peptide chain release factors; Region: PCRF; smart00937 710696007226 RF-1 domain; Region: RF-1; pfam00472 710696007227 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 710696007228 transcription termination factor Rho; Provisional; Region: PRK12678 710696007229 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 710696007230 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 710696007231 RNA binding site [nucleotide binding]; other site 710696007232 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 710696007233 multimer interface [polypeptide binding]; other site 710696007234 Walker A motif; other site 710696007235 ATP binding site [chemical binding]; other site 710696007236 Walker B motif; other site 710696007237 homoserine kinase; Provisional; Region: PRK01212 710696007238 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 710696007239 threonine synthase; Reviewed; Region: PRK06721 710696007240 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 710696007241 homodimer interface [polypeptide binding]; other site 710696007242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696007243 catalytic residue [active] 710696007244 homoserine dehydrogenase; Provisional; Region: PRK06349 710696007245 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 710696007246 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 710696007247 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 710696007248 diaminopimelate decarboxylase; Region: lysA; TIGR01048 710696007249 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 710696007250 active site 710696007251 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710696007252 substrate binding site [chemical binding]; other site 710696007253 catalytic residues [active] 710696007254 dimer interface [polypeptide binding]; other site 710696007255 DALR anticodon binding domain; Region: DALR_1; smart00836 710696007256 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 710696007257 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 710696007258 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 710696007259 DctM-like transporters; Region: DctM; pfam06808 710696007260 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 710696007261 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 710696007262 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 710696007263 N- and C-terminal domain interface [polypeptide binding]; other site 710696007264 active site 710696007265 catalytic site [active] 710696007266 metal binding site [ion binding]; metal-binding site 710696007267 carbohydrate binding site [chemical binding]; other site 710696007268 ATP binding site [chemical binding]; other site 710696007269 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 710696007270 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 710696007271 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 710696007272 glucuronate isomerase; Reviewed; Region: PRK02925 710696007273 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 710696007274 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 710696007275 Transcriptional regulators [Transcription]; Region: PurR; COG1609 710696007276 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 710696007277 DNA binding site [nucleotide binding] 710696007278 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 710696007279 dimerization interface [polypeptide binding]; other site 710696007280 ligand binding site [chemical binding]; other site 710696007281 Transcriptional regulators [Transcription]; Region: PurR; COG1609 710696007282 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 710696007283 DNA binding site [nucleotide binding] 710696007284 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 710696007285 dimerization interface [polypeptide binding]; other site 710696007286 ligand binding site [chemical binding]; other site 710696007287 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 710696007288 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 710696007289 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710696007290 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 710696007291 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 710696007292 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 710696007293 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 710696007294 Ligand Binding Site [chemical binding]; other site 710696007295 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 710696007296 AIR carboxylase; Region: AIRC; smart01001 710696007297 hypothetical protein; Provisional; Region: PRK04194 710696007298 Domain of unknown function DUF21; Region: DUF21; pfam01595 710696007299 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 710696007300 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 710696007301 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 710696007302 Domain of unknown function DUF21; Region: DUF21; pfam01595 710696007303 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 710696007304 Transporter associated domain; Region: CorC_HlyC; smart01091 710696007305 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 710696007306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696007307 Walker A/P-loop; other site 710696007308 ATP binding site [chemical binding]; other site 710696007309 Q-loop/lid; other site 710696007310 ABC transporter signature motif; other site 710696007311 Walker B; other site 710696007312 D-loop; other site 710696007313 H-loop/switch region; other site 710696007314 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 710696007315 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 710696007316 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 710696007317 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 710696007318 TPP-binding site [chemical binding]; other site 710696007319 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 710696007320 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 710696007321 active site 710696007322 catalytic triad [active] 710696007323 oxyanion hole [active] 710696007324 Transcription factor WhiB; Region: Whib; pfam02467 710696007325 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 710696007326 PAS fold; Region: PAS_4; pfam08448 710696007327 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 710696007328 putative active site [active] 710696007329 heme pocket [chemical binding]; other site 710696007330 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 710696007331 Histidine kinase; Region: HisKA_2; pfam07568 710696007332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696007333 ATP binding site [chemical binding]; other site 710696007334 Mg2+ binding site [ion binding]; other site 710696007335 G-X-G motif; other site 710696007336 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 710696007337 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 710696007338 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710696007339 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 710696007340 NAD(P) binding site [chemical binding]; other site 710696007341 catalytic residues [active] 710696007342 Tic20-like protein; Region: Tic20; pfam09685 710696007343 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 710696007344 active site 710696007345 catalytic triad [active] 710696007346 oxyanion hole [active] 710696007347 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710696007348 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710696007349 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 710696007350 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 710696007351 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710696007352 This domain family includes a range of different proteins. Such as antifreeze proteins and flagellar FlgA proteins, and CpaB pilus proteins; Region: SAF; smart00858 710696007353 Helix-turn-helix domain; Region: HTH_17; pfam12728 710696007354 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 710696007355 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 710696007356 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 710696007357 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 710696007358 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 710696007359 nucleotide binding region [chemical binding]; other site 710696007360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 710696007361 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 710696007362 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710696007363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696007364 active site 710696007365 phosphorylation site [posttranslational modification] 710696007366 intermolecular recognition site; other site 710696007367 dimerization interface [polypeptide binding]; other site 710696007368 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710696007369 dimerization interface [polypeptide binding]; other site 710696007370 DNA binding residues [nucleotide binding] 710696007371 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 710696007372 30S subunit binding site; other site 710696007373 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 710696007374 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710696007375 active site 710696007376 lipoprotein LpqB; Provisional; Region: PRK13613 710696007377 Sporulation and spore germination; Region: Germane; pfam10646 710696007378 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710696007379 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 710696007380 dimerization interface [polypeptide binding]; other site 710696007381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710696007382 dimer interface [polypeptide binding]; other site 710696007383 phosphorylation site [posttranslational modification] 710696007384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696007385 ATP binding site [chemical binding]; other site 710696007386 Mg2+ binding site [ion binding]; other site 710696007387 G-X-G motif; other site 710696007388 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710696007389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696007390 active site 710696007391 phosphorylation site [posttranslational modification] 710696007392 intermolecular recognition site; other site 710696007393 dimerization interface [polypeptide binding]; other site 710696007394 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710696007395 DNA binding site [nucleotide binding] 710696007396 Adenosylhomocysteinase; Provisional; Region: PTZ00075 710696007397 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 710696007398 homotetramer interface [polypeptide binding]; other site 710696007399 ligand binding site [chemical binding]; other site 710696007400 catalytic site [active] 710696007401 NAD binding site [chemical binding]; other site 710696007402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 710696007403 Bacterial phospho-glucose isomerase C-terminal region; Region: bact-PGI_C; pfam10432 710696007404 Trm112p-like protein; Region: Trm112p; cl01066 710696007405 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 710696007406 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 710696007407 active site 710696007408 substrate binding site [chemical binding]; other site 710696007409 metal binding site [ion binding]; metal-binding site 710696007410 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 710696007411 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 710696007412 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 710696007413 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 710696007414 active site 710696007415 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710696007416 Transcription factor WhiB; Region: Whib; pfam02467 710696007417 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 710696007418 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 710696007419 phosphate binding site [ion binding]; other site 710696007420 dimer interface [polypeptide binding]; other site 710696007421 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 710696007422 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 710696007423 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710696007424 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710696007425 NAD(P) binding site [chemical binding]; other site 710696007426 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 710696007427 Malic enzyme, N-terminal domain; Region: malic; pfam00390 710696007428 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 710696007429 NAD(P) binding pocket [chemical binding]; other site 710696007430 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710696007431 Zn2+ binding site [ion binding]; other site 710696007432 Mg2+ binding site [ion binding]; other site 710696007433 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710696007434 Zn2+ binding site [ion binding]; other site 710696007435 Mg2+ binding site [ion binding]; other site 710696007436 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 710696007437 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696007438 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710696007439 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710696007440 DNA binding residues [nucleotide binding] 710696007441 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 710696007442 Uncharacterized conserved protein [Function unknown]; Region: COG2135 710696007443 Predicted membrane protein [Function unknown]; Region: COG2259 710696007444 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 710696007445 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 710696007446 hinge; other site 710696007447 active site 710696007448 Predicted GTPases [General function prediction only]; Region: COG1162 710696007449 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 710696007450 GTPase/Zn-binding domain interface [polypeptide binding]; other site 710696007451 GTP/Mg2+ binding site [chemical binding]; other site 710696007452 G4 box; other site 710696007453 G5 box; other site 710696007454 G1 box; other site 710696007455 Switch I region; other site 710696007456 G2 box; other site 710696007457 G3 box; other site 710696007458 Switch II region; other site 710696007459 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 710696007460 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 710696007461 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 710696007462 active site 710696007463 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 710696007464 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 710696007465 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 710696007466 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 710696007467 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 710696007468 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 710696007469 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 710696007470 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710696007471 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710696007472 catalytic residue [active] 710696007473 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 710696007474 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 710696007475 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 710696007476 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 710696007477 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 710696007478 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 710696007479 MoaE homodimer interface [polypeptide binding]; other site 710696007480 MoaD interaction [polypeptide binding]; other site 710696007481 active site residues [active] 710696007482 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 710696007483 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 710696007484 nudix motif; other site 710696007485 Protein of unknown function DUF45; Region: DUF45; pfam01863 710696007486 DNA polymerase II large subunit; Validated; Region: PRK04023 710696007487 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 710696007488 ABC1 family; Region: ABC1; pfam03109 710696007489 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 710696007490 active site 710696007491 ATP binding site [chemical binding]; other site 710696007492 Transcription factor WhiB; Region: Whib; pfam02467 710696007493 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 710696007494 Part of AAA domain; Region: AAA_19; pfam13245 710696007495 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 710696007496 Family description; Region: UvrD_C_2; pfam13538 710696007497 HRDC domain; Region: HRDC; pfam00570 710696007498 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 710696007499 catalytic residues [active] 710696007500 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 710696007501 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 710696007502 putative NADH binding site [chemical binding]; other site 710696007503 putative active site [active] 710696007504 nudix motif; other site 710696007505 putative metal binding site [ion binding]; other site 710696007506 Phosphotransferase enzyme family; Region: APH; pfam01636 710696007507 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 710696007508 active site 710696007509 substrate binding site [chemical binding]; other site 710696007510 ATP binding site [chemical binding]; other site 710696007511 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 710696007512 Part of AAA domain; Region: AAA_19; pfam13245 710696007513 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 710696007514 Family description; Region: UvrD_C_2; pfam13538 710696007515 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 710696007516 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 710696007517 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 710696007518 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 710696007519 active site 710696007520 DNA binding site [nucleotide binding] 710696007521 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 710696007522 putative dimer interface [polypeptide binding]; other site 710696007523 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710696007524 ligand binding site [chemical binding]; other site 710696007525 Zn binding site [ion binding]; other site 710696007526 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 710696007527 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 710696007528 ATP binding site [chemical binding]; other site 710696007529 substrate interface [chemical binding]; other site 710696007530 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710696007531 active site residue [active] 710696007532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710696007533 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696007534 WHG domain; Region: WHG; pfam13305 710696007535 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 710696007536 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 710696007537 helicase 45; Provisional; Region: PTZ00424 710696007538 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 710696007539 ATP binding site [chemical binding]; other site 710696007540 Mg++ binding site [ion binding]; other site 710696007541 motif III; other site 710696007542 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710696007543 nucleotide binding region [chemical binding]; other site 710696007544 ATP-binding site [chemical binding]; other site 710696007545 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710696007546 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710696007547 P-loop; other site 710696007548 Magnesium ion binding site [ion binding]; other site 710696007549 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710696007550 Magnesium ion binding site [ion binding]; other site 710696007551 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 710696007552 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 710696007553 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 710696007554 active site 710696007555 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 710696007556 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710696007557 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696007558 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710696007559 DNA binding residues [nucleotide binding] 710696007560 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 710696007561 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 710696007562 putative active site [active] 710696007563 putative catalytic site [active] 710696007564 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 710696007565 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 710696007566 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 710696007567 active site 710696007568 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710696007569 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710696007570 active site 710696007571 DinB superfamily; Region: DinB_2; pfam12867 710696007572 PemK-like protein; Region: PemK; pfam02452 710696007573 Caspase domain; Region: Peptidase_C14; pfam00656 710696007574 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 710696007575 CHAT domain; Region: CHAT; cl17868 710696007576 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 710696007577 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 710696007578 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 710696007579 putative active site [active] 710696007580 putative ligand binding site [chemical binding]; other site 710696007581 putative NAD(P) binding site [chemical binding]; other site 710696007582 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 710696007583 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 710696007584 MgtE intracellular N domain; Region: MgtE_N; smart00924 710696007585 FOG: CBS domain [General function prediction only]; Region: COG0517 710696007586 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 710696007587 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 710696007588 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 710696007589 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 710696007590 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 710696007591 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 710696007592 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 710696007593 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710696007594 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 710696007595 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 710696007596 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 710696007597 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696007598 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710696007599 DNA binding residues [nucleotide binding] 710696007600 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 710696007601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710696007602 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 710696007603 enoyl-CoA hydratase; Provisional; Region: PRK06688 710696007604 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710696007605 substrate binding site [chemical binding]; other site 710696007606 oxyanion hole (OAH) forming residues; other site 710696007607 trimer interface [polypeptide binding]; other site 710696007608 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 710696007609 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 710696007610 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 710696007611 metal binding site [ion binding]; metal-binding site 710696007612 putative dimer interface [polypeptide binding]; other site 710696007613 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 710696007614 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 710696007615 putative trimer interface [polypeptide binding]; other site 710696007616 putative CoA binding site [chemical binding]; other site 710696007617 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 710696007618 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 710696007619 dimer interface [polypeptide binding]; other site 710696007620 active site 710696007621 citrylCoA binding site [chemical binding]; other site 710696007622 NADH binding [chemical binding]; other site 710696007623 cationic pore residues; other site 710696007624 oxalacetate/citrate binding site [chemical binding]; other site 710696007625 coenzyme A binding site [chemical binding]; other site 710696007626 catalytic triad [active] 710696007627 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 710696007628 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710696007629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696007630 homodimer interface [polypeptide binding]; other site 710696007631 catalytic residue [active] 710696007632 Ferredoxin [Energy production and conversion]; Region: COG1146 710696007633 4Fe-4S binding domain; Region: Fer4; pfam00037 710696007634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696007635 Coenzyme A binding pocket [chemical binding]; other site 710696007636 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 710696007637 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 710696007638 VanW like protein; Region: VanW; pfam04294 710696007639 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 710696007640 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 710696007641 peptide binding site [polypeptide binding]; other site 710696007642 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 710696007643 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 710696007644 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 710696007645 G1 box; other site 710696007646 putative GEF interaction site [polypeptide binding]; other site 710696007647 GTP/Mg2+ binding site [chemical binding]; other site 710696007648 Switch I region; other site 710696007649 G2 box; other site 710696007650 G3 box; other site 710696007651 Switch II region; other site 710696007652 G4 box; other site 710696007653 G5 box; other site 710696007654 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 710696007655 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 710696007656 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 710696007657 active site 710696007658 8-oxo-dGMP binding site [chemical binding]; other site 710696007659 nudix motif; other site 710696007660 metal binding site [ion binding]; metal-binding site 710696007661 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 710696007662 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 710696007663 peptide binding site [polypeptide binding]; other site 710696007664 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 710696007665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696007666 dimer interface [polypeptide binding]; other site 710696007667 conserved gate region; other site 710696007668 putative PBP binding loops; other site 710696007669 ABC-ATPase subunit interface; other site 710696007670 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 710696007671 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 710696007672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696007673 dimer interface [polypeptide binding]; other site 710696007674 conserved gate region; other site 710696007675 putative PBP binding loops; other site 710696007676 ABC-ATPase subunit interface; other site 710696007677 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 710696007678 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710696007679 Walker A/P-loop; other site 710696007680 ATP binding site [chemical binding]; other site 710696007681 Q-loop/lid; other site 710696007682 ABC transporter signature motif; other site 710696007683 Walker B; other site 710696007684 D-loop; other site 710696007685 H-loop/switch region; other site 710696007686 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710696007687 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 710696007688 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710696007689 Walker A/P-loop; other site 710696007690 ATP binding site [chemical binding]; other site 710696007691 Q-loop/lid; other site 710696007692 ABC transporter signature motif; other site 710696007693 Walker B; other site 710696007694 D-loop; other site 710696007695 H-loop/switch region; other site 710696007696 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710696007697 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710696007698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696007699 NAD(P) binding site [chemical binding]; other site 710696007700 active site 710696007701 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 710696007702 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 710696007703 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696007704 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710696007705 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 710696007706 putative active site [active] 710696007707 putative metal binding site [ion binding]; other site 710696007708 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 710696007709 Chain length determinant protein; Region: Wzz; pfam02706 710696007710 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 710696007711 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 710696007712 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 710696007713 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696007714 putative ADP-binding pocket [chemical binding]; other site 710696007715 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696007716 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710696007717 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710696007718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696007719 Walker A/P-loop; other site 710696007720 ATP binding site [chemical binding]; other site 710696007721 Q-loop/lid; other site 710696007722 ABC transporter signature motif; other site 710696007723 Walker B; other site 710696007724 D-loop; other site 710696007725 H-loop/switch region; other site 710696007726 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696007727 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710696007728 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696007729 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 710696007730 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 710696007731 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 710696007732 active site 710696007733 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 710696007734 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 710696007735 inhibitor-cofactor binding pocket; inhibition site 710696007736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696007737 catalytic residue [active] 710696007738 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 710696007739 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 710696007740 NAD(P) binding site [chemical binding]; other site 710696007741 homodimer interface [polypeptide binding]; other site 710696007742 substrate binding site [chemical binding]; other site 710696007743 active site 710696007744 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 710696007745 ligand binding site; other site 710696007746 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 710696007747 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710696007748 pseudaminic acid synthase; Region: PseI; TIGR03586 710696007749 NeuB family; Region: NeuB; pfam03102 710696007750 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 710696007751 NeuB binding interface [polypeptide binding]; other site 710696007752 putative substrate binding site [chemical binding]; other site 710696007753 Winged helix-turn helix; Region: HTH_29; pfam13551 710696007754 Homeodomain-like domain; Region: HTH_23; cl17451 710696007755 Integrase core domain; Region: rve; pfam00665 710696007756 Integrase core domain; Region: rve_3; pfam13683 710696007757 Bacterial sugar transferase; Region: Bac_transf; pfam02397 710696007758 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 710696007759 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 710696007760 inhibitor-cofactor binding pocket; inhibition site 710696007761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696007762 catalytic residue [active] 710696007763 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 710696007764 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 710696007765 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 710696007766 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710696007767 CoA-binding domain; Region: CoA_binding_3; pfam13727 710696007768 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 710696007769 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 710696007770 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 710696007771 NAD(P) binding site [chemical binding]; other site 710696007772 homodimer interface [polypeptide binding]; other site 710696007773 substrate binding site [chemical binding]; other site 710696007774 active site 710696007775 Predicted transcriptional regulators [Transcription]; Region: COG1733 710696007776 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696007777 dimerization interface [polypeptide binding]; other site 710696007778 putative DNA binding site [nucleotide binding]; other site 710696007779 putative Zn2+ binding site [ion binding]; other site 710696007780 Methyltransferase domain; Region: Methyltransf_11; pfam08241 710696007781 PGAP1-like protein; Region: PGAP1; pfam07819 710696007782 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710696007783 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710696007784 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710696007785 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710696007786 active site 710696007787 ATP binding site [chemical binding]; other site 710696007788 substrate binding site [chemical binding]; other site 710696007789 activation loop (A-loop); other site 710696007790 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696007791 dimerization interface [polypeptide binding]; other site 710696007792 putative DNA binding site [nucleotide binding]; other site 710696007793 putative Zn2+ binding site [ion binding]; other site 710696007794 Cation efflux family; Region: Cation_efflux; cl00316 710696007795 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 710696007796 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 710696007797 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 710696007798 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 710696007799 Predicted ATPase [General function prediction only]; Region: COG3899 710696007800 AAA ATPase domain; Region: AAA_16; pfam13191 710696007801 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710696007802 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710696007803 DNA binding residues [nucleotide binding] 710696007804 dimerization interface [polypeptide binding]; other site 710696007805 FAD binding domain; Region: FAD_binding_4; pfam01565 710696007806 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710696007807 Berberine and berberine like; Region: BBE; pfam08031 710696007808 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 710696007809 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710696007810 Walker A/P-loop; other site 710696007811 ATP binding site [chemical binding]; other site 710696007812 Q-loop/lid; other site 710696007813 ABC transporter signature motif; other site 710696007814 Walker B; other site 710696007815 D-loop; other site 710696007816 H-loop/switch region; other site 710696007817 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 710696007818 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 710696007819 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710696007820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696007821 active site 710696007822 phosphorylation site [posttranslational modification] 710696007823 intermolecular recognition site; other site 710696007824 dimerization interface [polypeptide binding]; other site 710696007825 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710696007826 DNA binding site [nucleotide binding] 710696007827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710696007828 dimer interface [polypeptide binding]; other site 710696007829 phosphorylation site [posttranslational modification] 710696007830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696007831 ATP binding site [chemical binding]; other site 710696007832 Mg2+ binding site [ion binding]; other site 710696007833 G-X-G motif; other site 710696007834 D5 N terminal like; Region: D5_N; pfam08706 710696007835 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 710696007836 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 710696007837 Transcription factor WhiB; Region: Whib; pfam02467 710696007838 Phage capsid family; Region: Phage_capsid; pfam05065 710696007839 GTP-binding protein YchF; Reviewed; Region: PRK09601 710696007840 YchF GTPase; Region: YchF; cd01900 710696007841 G1 box; other site 710696007842 GTP/Mg2+ binding site [chemical binding]; other site 710696007843 Switch I region; other site 710696007844 G2 box; other site 710696007845 Switch II region; other site 710696007846 G3 box; other site 710696007847 G4 box; other site 710696007848 G5 box; other site 710696007849 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 710696007850 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710696007851 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 710696007852 active site 2 [active] 710696007853 RmuC family; Region: RmuC; pfam02646 710696007854 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 710696007855 metal ion-dependent adhesion site (MIDAS); other site 710696007856 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 710696007857 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 710696007858 metal ion-dependent adhesion site (MIDAS); other site 710696007859 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 710696007860 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 710696007861 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 710696007862 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 710696007863 generic binding surface II; other site 710696007864 generic binding surface I; other site 710696007865 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 710696007866 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 710696007867 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 710696007868 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 710696007869 putative active site [active] 710696007870 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710696007871 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 710696007872 putative substrate binding site [chemical binding]; other site 710696007873 putative ATP binding site [chemical binding]; other site 710696007874 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 710696007875 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 710696007876 metal ion-dependent adhesion site (MIDAS); other site 710696007877 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 710696007878 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710696007879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696007880 dimer interface [polypeptide binding]; other site 710696007881 conserved gate region; other site 710696007882 putative PBP binding loops; other site 710696007883 ABC-ATPase subunit interface; other site 710696007884 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710696007885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696007886 dimer interface [polypeptide binding]; other site 710696007887 conserved gate region; other site 710696007888 putative PBP binding loops; other site 710696007889 ABC-ATPase subunit interface; other site 710696007890 fumarate hydratase; Provisional; Region: PRK15389 710696007891 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 710696007892 Fumarase C-terminus; Region: Fumerase_C; pfam05683 710696007893 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 710696007894 active site clefts [active] 710696007895 zinc binding site [ion binding]; other site 710696007896 dimer interface [polypeptide binding]; other site 710696007897 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 710696007898 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 710696007899 active site 710696007900 Zn binding site [ion binding]; other site 710696007901 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 710696007902 Domain of unknown function (DUF309); Region: DUF309; pfam03745 710696007903 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 710696007904 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 710696007905 active site 710696007906 substrate binding site [chemical binding]; other site 710696007907 metal binding site [ion binding]; metal-binding site 710696007908 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 710696007909 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 710696007910 23S rRNA interface [nucleotide binding]; other site 710696007911 L3 interface [polypeptide binding]; other site 710696007912 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696007913 dimerization interface [polypeptide binding]; other site 710696007914 putative DNA binding site [nucleotide binding]; other site 710696007915 putative Zn2+ binding site [ion binding]; other site 710696007916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696007917 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710696007918 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710696007919 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710696007920 active site 710696007921 catalytic tetrad [active] 710696007922 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 710696007923 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 710696007924 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 710696007925 active site 710696007926 catalytic site [active] 710696007927 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 710696007928 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 710696007929 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 710696007930 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 710696007931 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 710696007932 Ca binding site [ion binding]; other site 710696007933 active site 710696007934 catalytic site [active] 710696007935 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 710696007936 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 710696007937 putative deacylase active site [active] 710696007938 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710696007939 Nitronate monooxygenase; Region: NMO; pfam03060 710696007940 FMN binding site [chemical binding]; other site 710696007941 substrate binding site [chemical binding]; other site 710696007942 putative catalytic residue [active] 710696007943 Stage II sporulation protein; Region: SpoIID; pfam08486 710696007944 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 710696007945 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 710696007946 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 710696007947 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 710696007948 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 710696007949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696007950 Walker A/P-loop; other site 710696007951 ATP binding site [chemical binding]; other site 710696007952 ABC transporter signature motif; other site 710696007953 Walker B; other site 710696007954 D-loop; other site 710696007955 H-loop/switch region; other site 710696007956 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710696007957 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 710696007958 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 710696007959 dimerization interface 3.5A [polypeptide binding]; other site 710696007960 active site 710696007961 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 710696007962 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 710696007963 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 710696007964 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 710696007965 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 710696007966 alphaNTD - beta interaction site [polypeptide binding]; other site 710696007967 alphaNTD homodimer interface [polypeptide binding]; other site 710696007968 alphaNTD - beta' interaction site [polypeptide binding]; other site 710696007969 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 710696007970 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 710696007971 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 710696007972 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710696007973 RNA binding surface [nucleotide binding]; other site 710696007974 30S ribosomal protein S11; Validated; Region: PRK05309 710696007975 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 710696007976 30S ribosomal protein S13; Region: bact_S13; TIGR03631 710696007977 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 710696007978 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 710696007979 rRNA binding site [nucleotide binding]; other site 710696007980 predicted 30S ribosome binding site; other site 710696007981 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 710696007982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696007983 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710696007984 putative substrate translocation pore; other site 710696007985 glutamate dehydrogenase; Provisional; Region: PRK09414 710696007986 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 710696007987 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 710696007988 NAD(P) binding site [chemical binding]; other site 710696007989 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 710696007990 active site 710696007991 adenylate kinase; Reviewed; Region: adk; PRK00279 710696007992 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 710696007993 AMP-binding site [chemical binding]; other site 710696007994 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 710696007995 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 710696007996 SecY translocase; Region: SecY; pfam00344 710696007997 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 710696007998 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 710696007999 23S rRNA binding site [nucleotide binding]; other site 710696008000 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 710696008001 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 710696008002 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 710696008003 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 710696008004 5S rRNA interface [nucleotide binding]; other site 710696008005 L27 interface [polypeptide binding]; other site 710696008006 23S rRNA interface [nucleotide binding]; other site 710696008007 L5 interface [polypeptide binding]; other site 710696008008 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 710696008009 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 710696008010 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 710696008011 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 710696008012 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 710696008013 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 710696008014 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 710696008015 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 710696008016 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 710696008017 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 710696008018 RNA binding site [nucleotide binding]; other site 710696008019 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 710696008020 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 710696008021 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 710696008022 putative translocon interaction site; other site 710696008023 23S rRNA interface [nucleotide binding]; other site 710696008024 signal recognition particle (SRP54) interaction site; other site 710696008025 L23 interface [polypeptide binding]; other site 710696008026 trigger factor interaction site; other site 710696008027 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 710696008028 23S rRNA interface [nucleotide binding]; other site 710696008029 5S rRNA interface [nucleotide binding]; other site 710696008030 putative antibiotic binding site [chemical binding]; other site 710696008031 L25 interface [polypeptide binding]; other site 710696008032 L27 interface [polypeptide binding]; other site 710696008033 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 710696008034 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 710696008035 G-X-X-G motif; other site 710696008036 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 710696008037 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 710696008038 putative translocon binding site; other site 710696008039 protein-rRNA interface [nucleotide binding]; other site 710696008040 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 710696008041 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 710696008042 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 710696008043 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 710696008044 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 710696008045 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 710696008046 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 710696008047 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 710696008048 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 710696008049 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 710696008050 active site 710696008051 metal binding site [ion binding]; metal-binding site 710696008052 elongation factor Tu; Reviewed; Region: PRK00049 710696008053 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 710696008054 G1 box; other site 710696008055 GEF interaction site [polypeptide binding]; other site 710696008056 GTP/Mg2+ binding site [chemical binding]; other site 710696008057 Switch I region; other site 710696008058 G2 box; other site 710696008059 G3 box; other site 710696008060 Switch II region; other site 710696008061 G4 box; other site 710696008062 G5 box; other site 710696008063 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 710696008064 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 710696008065 Antibiotic Binding Site [chemical binding]; other site 710696008066 elongation factor G; Reviewed; Region: PRK00007 710696008067 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 710696008068 G1 box; other site 710696008069 putative GEF interaction site [polypeptide binding]; other site 710696008070 GTP/Mg2+ binding site [chemical binding]; other site 710696008071 Switch I region; other site 710696008072 G2 box; other site 710696008073 G3 box; other site 710696008074 Switch II region; other site 710696008075 G4 box; other site 710696008076 G5 box; other site 710696008077 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 710696008078 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 710696008079 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 710696008080 30S ribosomal protein S7; Validated; Region: PRK05302 710696008081 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 710696008082 S17 interaction site [polypeptide binding]; other site 710696008083 S8 interaction site; other site 710696008084 16S rRNA interaction site [nucleotide binding]; other site 710696008085 streptomycin interaction site [chemical binding]; other site 710696008086 23S rRNA interaction site [nucleotide binding]; other site 710696008087 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 710696008088 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 710696008089 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 710696008090 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 710696008091 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 710696008092 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 710696008093 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 710696008094 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 710696008095 G-loop; other site 710696008096 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 710696008097 DNA binding site [nucleotide binding] 710696008098 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 710696008099 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 710696008100 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 710696008101 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 710696008102 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 710696008103 RPB10 interaction site [polypeptide binding]; other site 710696008104 RPB1 interaction site [polypeptide binding]; other site 710696008105 RPB11 interaction site [polypeptide binding]; other site 710696008106 RPB3 interaction site [polypeptide binding]; other site 710696008107 RPB12 interaction site [polypeptide binding]; other site 710696008108 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 710696008109 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 710696008110 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 710696008111 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 710696008112 active site 710696008113 catalytic triad [active] 710696008114 dimer interface [polypeptide binding]; other site 710696008115 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710696008116 mce related protein; Region: MCE; pfam02470 710696008117 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710696008118 mce related protein; Region: MCE; pfam02470 710696008119 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710696008120 mce related protein; Region: MCE; pfam02470 710696008121 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710696008122 mce related protein; Region: MCE; pfam02470 710696008123 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710696008124 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710696008125 mce related protein; Region: MCE; pfam02470 710696008126 mce related protein; Region: MCE; pfam02470 710696008127 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710696008128 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710696008129 Permease; Region: Permease; pfam02405 710696008130 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710696008131 Permease; Region: Permease; pfam02405 710696008132 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 710696008133 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 710696008134 Walker A/P-loop; other site 710696008135 ATP binding site [chemical binding]; other site 710696008136 Q-loop/lid; other site 710696008137 ABC transporter signature motif; other site 710696008138 Walker B; other site 710696008139 D-loop; other site 710696008140 H-loop/switch region; other site 710696008141 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 710696008142 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710696008143 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 710696008144 dimerization interface [polypeptide binding]; other site 710696008145 LysE type translocator; Region: LysE; cl00565 710696008146 LysE type translocator; Region: LysE; cl00565 710696008147 Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887 710696008148 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 710696008149 core dimer interface [polypeptide binding]; other site 710696008150 peripheral dimer interface [polypeptide binding]; other site 710696008151 L10 interface [polypeptide binding]; other site 710696008152 L11 interface [polypeptide binding]; other site 710696008153 putative EF-Tu interaction site [polypeptide binding]; other site 710696008154 putative EF-G interaction site [polypeptide binding]; other site 710696008155 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 710696008156 23S rRNA interface [nucleotide binding]; other site 710696008157 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 710696008158 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 710696008159 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 710696008160 mRNA/rRNA interface [nucleotide binding]; other site 710696008161 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 710696008162 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 710696008163 23S rRNA interface [nucleotide binding]; other site 710696008164 L7/L12 interface [polypeptide binding]; other site 710696008165 putative thiostrepton binding site; other site 710696008166 L25 interface [polypeptide binding]; other site 710696008167 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 710696008168 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 710696008169 putative homodimer interface [polypeptide binding]; other site 710696008170 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 710696008171 heterodimer interface [polypeptide binding]; other site 710696008172 homodimer interface [polypeptide binding]; other site 710696008173 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 710696008174 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 710696008175 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710696008176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696008177 homodimer interface [polypeptide binding]; other site 710696008178 catalytic residue [active] 710696008179 adenosine deaminase; Provisional; Region: PRK09358 710696008180 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 710696008181 active site 710696008182 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 710696008183 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 710696008184 FAD binding domain; Region: FAD_binding_4; pfam01565 710696008185 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 710696008186 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 710696008187 active site 710696008188 catalytic site [active] 710696008189 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710696008190 active site 710696008191 catalytic site [active] 710696008192 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 710696008193 Domain of unknown function DUF20; Region: UPF0118; pfam01594 710696008194 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 710696008195 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696008196 Coenzyme A binding pocket [chemical binding]; other site 710696008197 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710696008198 MMPL family; Region: MMPL; pfam03176 710696008199 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 710696008200 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 710696008201 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 710696008202 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 710696008203 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 710696008204 intersubunit interface [polypeptide binding]; other site 710696008205 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 710696008206 B12 binding site [chemical binding]; other site 710696008207 cobalt ligand [ion binding]; other site 710696008208 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 710696008209 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710696008210 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 710696008211 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710696008212 MarR family; Region: MarR; pfam01047 710696008213 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710696008214 ligand binding site [chemical binding]; other site 710696008215 flexible hinge region; other site 710696008216 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710696008217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696008218 ATP binding site [chemical binding]; other site 710696008219 Mg2+ binding site [ion binding]; other site 710696008220 G-X-G motif; other site 710696008221 Response regulator receiver domain; Region: Response_reg; pfam00072 710696008222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696008223 active site 710696008224 phosphorylation site [posttranslational modification] 710696008225 intermolecular recognition site; other site 710696008226 dimerization interface [polypeptide binding]; other site 710696008227 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710696008228 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 710696008229 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710696008230 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710696008231 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 710696008232 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 710696008233 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 710696008234 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 710696008235 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 710696008236 dimer interface [polypeptide binding]; other site 710696008237 active site 710696008238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710696008239 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 710696008240 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710696008241 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710696008242 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696008243 putative DNA binding site [nucleotide binding]; other site 710696008244 putative Zn2+ binding site [ion binding]; other site 710696008245 Domain of unknown function DUF59; Region: DUF59; pfam01883 710696008246 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 710696008247 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 710696008248 Walker A motif; other site 710696008249 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710696008250 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 710696008251 molybdopterin cofactor binding site; other site 710696008252 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 710696008253 putative molybdopterin cofactor binding site; other site 710696008254 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 710696008255 4Fe-4S binding domain; Region: Fer4; pfam00037 710696008256 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 710696008257 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 710696008258 CPxP motif; other site 710696008259 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 710696008260 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 710696008261 active site residue [active] 710696008262 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 710696008263 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696008264 dimerization interface [polypeptide binding]; other site 710696008265 putative DNA binding site [nucleotide binding]; other site 710696008266 putative Zn2+ binding site [ion binding]; other site 710696008267 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 710696008268 active site 710696008269 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710696008270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696008271 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 710696008272 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710696008273 amidase; Provisional; Region: PRK07486 710696008274 Amidase; Region: Amidase; cl11426 710696008275 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 710696008276 putative catalytic site [active] 710696008277 putative metal binding site [ion binding]; other site 710696008278 putative phosphate binding site [ion binding]; other site 710696008279 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 710696008280 active site pocket [active] 710696008281 cleavage site 710696008282 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710696008283 dimer interface [polypeptide binding]; other site 710696008284 phosphorylation site [posttranslational modification] 710696008285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696008286 ATP binding site [chemical binding]; other site 710696008287 Mg2+ binding site [ion binding]; other site 710696008288 G-X-G motif; other site 710696008289 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 710696008290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696008291 active site 710696008292 phosphorylation site [posttranslational modification] 710696008293 intermolecular recognition site; other site 710696008294 dimerization interface [polypeptide binding]; other site 710696008295 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710696008296 DNA binding site [nucleotide binding] 710696008297 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 710696008298 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710696008299 FeS/SAM binding site; other site 710696008300 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 710696008301 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 710696008302 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 710696008303 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 710696008304 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710696008305 DNA-binding site [nucleotide binding]; DNA binding site 710696008306 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710696008307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696008308 homodimer interface [polypeptide binding]; other site 710696008309 catalytic residue [active] 710696008310 EamA-like transporter family; Region: EamA; pfam00892 710696008311 YcfA-like protein; Region: YcfA; cl00752 710696008312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710696008313 non-specific DNA binding site [nucleotide binding]; other site 710696008314 salt bridge; other site 710696008315 sequence-specific DNA binding site [nucleotide binding]; other site 710696008316 HEAT repeats; Region: HEAT_2; pfam13646 710696008317 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 710696008318 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 710696008319 protein-splicing catalytic site; other site 710696008320 thioester formation/cholesterol transfer; other site 710696008321 Pretoxin HINT domain; Region: PT-HINT; pfam07591 710696008322 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 710696008323 amphipathic channel; other site 710696008324 Asn-Pro-Ala signature motifs; other site 710696008325 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 710696008326 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 710696008327 NAD binding site [chemical binding]; other site 710696008328 catalytic Zn binding site [ion binding]; other site 710696008329 structural Zn binding site [ion binding]; other site 710696008330 Helix-turn-helix domain; Region: HTH_17; pfam12728 710696008331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 710696008332 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 710696008333 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 710696008334 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 710696008335 Malic enzyme, N-terminal domain; Region: malic; pfam00390 710696008336 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 710696008337 putative NAD(P) binding site [chemical binding]; other site 710696008338 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 710696008339 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 710696008340 nudix motif; other site 710696008341 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 710696008342 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 710696008343 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 710696008344 ring oligomerisation interface [polypeptide binding]; other site 710696008345 ATP/Mg binding site [chemical binding]; other site 710696008346 stacking interactions; other site 710696008347 hinge regions; other site 710696008348 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 710696008349 nucleotide binding site/active site [active] 710696008350 HIT family signature motif; other site 710696008351 catalytic residue [active] 710696008352 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710696008353 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 710696008354 putative active site pocket [active] 710696008355 cleavage site 710696008356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696008357 Coenzyme A binding pocket [chemical binding]; other site 710696008358 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 710696008359 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710696008360 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710696008361 catalytic residue [active] 710696008362 pyrophosphatase PpaX; Provisional; Region: PRK13288 710696008363 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710696008364 motif II; other site 710696008365 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 710696008366 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710696008367 active site 710696008368 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 710696008369 ligand binding site [chemical binding]; other site 710696008370 active site 710696008371 UGI interface [polypeptide binding]; other site 710696008372 catalytic site [active] 710696008373 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 710696008374 active site 710696008375 catalytic triad [active] 710696008376 oxyanion hole [active] 710696008377 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 710696008378 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 710696008379 putative active site [active] 710696008380 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 710696008381 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710696008382 inhibitor-cofactor binding pocket; inhibition site 710696008383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696008384 catalytic residue [active] 710696008385 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 710696008386 putative hydrophobic ligand binding site [chemical binding]; other site 710696008387 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696008388 dimerization interface [polypeptide binding]; other site 710696008389 putative DNA binding site [nucleotide binding]; other site 710696008390 putative Zn2+ binding site [ion binding]; other site 710696008391 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 710696008392 DNA binding residues [nucleotide binding] 710696008393 TOBE domain; Region: TOBE; cl01440 710696008394 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 710696008395 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710696008396 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 710696008397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696008398 putative PBP binding loops; other site 710696008399 ABC-ATPase subunit interface; other site 710696008400 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 710696008401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696008402 Walker A/P-loop; other site 710696008403 ATP binding site [chemical binding]; other site 710696008404 Q-loop/lid; other site 710696008405 ABC transporter signature motif; other site 710696008406 Walker B; other site 710696008407 D-loop; other site 710696008408 H-loop/switch region; other site 710696008409 TOBE domain; Region: TOBE; pfam03459 710696008410 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710696008411 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710696008412 active site 710696008413 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710696008414 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 710696008415 NAD binding site [chemical binding]; other site 710696008416 homodimer interface [polypeptide binding]; other site 710696008417 homotetramer interface [polypeptide binding]; other site 710696008418 active site 710696008419 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 710696008420 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696008421 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710696008422 DNA binding residues [nucleotide binding] 710696008423 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 710696008424 active site 710696008425 metal binding site [ion binding]; metal-binding site 710696008426 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 710696008427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696008428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696008429 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 710696008430 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 710696008431 metal binding site [ion binding]; metal-binding site 710696008432 putative dimer interface [polypeptide binding]; other site 710696008433 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 710696008434 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 710696008435 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 710696008436 putative active cleft [active] 710696008437 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 710696008438 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710696008439 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 710696008440 G1 box; other site 710696008441 GTP/Mg2+ binding site [chemical binding]; other site 710696008442 G2 box; other site 710696008443 Switch I region; other site 710696008444 Switch II region; other site 710696008445 G3 box; other site 710696008446 G4 box; other site 710696008447 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 710696008448 DNA-binding site [nucleotide binding]; DNA binding site 710696008449 RNA-binding motif; other site 710696008450 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 710696008451 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 710696008452 active site 710696008453 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 710696008454 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710696008455 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 710696008456 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 710696008457 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710696008458 sequence-specific DNA binding site [nucleotide binding]; other site 710696008459 salt bridge; other site 710696008460 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 710696008461 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 710696008462 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 710696008463 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 710696008464 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 710696008465 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710696008466 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710696008467 active site 710696008468 ATP binding site [chemical binding]; other site 710696008469 substrate binding site [chemical binding]; other site 710696008470 activation loop (A-loop); other site 710696008471 FOG: CBS domain [General function prediction only]; Region: COG0517 710696008472 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 710696008473 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 710696008474 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 710696008475 active site 710696008476 homotetramer interface [polypeptide binding]; other site 710696008477 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 710696008478 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 710696008479 Transcriptional regulators [Transcription]; Region: PurR; COG1609 710696008480 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 710696008481 DNA binding site [nucleotide binding] 710696008482 domain linker motif; other site 710696008483 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 710696008484 putative dimerization interface [polypeptide binding]; other site 710696008485 putative ligand binding site [chemical binding]; other site 710696008486 maltodextrin glucosidase; Provisional; Region: PRK10785 710696008487 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 710696008488 homodimer interface [polypeptide binding]; other site 710696008489 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 710696008490 active site 710696008491 homodimer interface [polypeptide binding]; other site 710696008492 catalytic site [active] 710696008493 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710696008494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696008495 dimer interface [polypeptide binding]; other site 710696008496 conserved gate region; other site 710696008497 putative PBP binding loops; other site 710696008498 ABC-ATPase subunit interface; other site 710696008499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696008500 dimer interface [polypeptide binding]; other site 710696008501 conserved gate region; other site 710696008502 putative PBP binding loops; other site 710696008503 ABC-ATPase subunit interface; other site 710696008504 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 710696008505 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 710696008506 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 710696008507 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 710696008508 Walker A/P-loop; other site 710696008509 ATP binding site [chemical binding]; other site 710696008510 Q-loop/lid; other site 710696008511 ABC transporter signature motif; other site 710696008512 Walker B; other site 710696008513 D-loop; other site 710696008514 H-loop/switch region; other site 710696008515 TOBE domain; Region: TOBE; pfam03459 710696008516 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 710696008517 Vitamin K epoxide reductase family in archaea and some bacteria; Region: VKOR_arc; cd12918 710696008518 putative active site [active] 710696008519 redox center [active] 710696008520 Domain of unknown function (DUF929); Region: DUF929; pfam06053 710696008521 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 710696008522 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 710696008523 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 710696008524 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 710696008525 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710696008526 active site 710696008527 HIGH motif; other site 710696008528 nucleotide binding site [chemical binding]; other site 710696008529 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 710696008530 KMSKS motif; other site 710696008531 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 710696008532 tRNA binding surface [nucleotide binding]; other site 710696008533 anticodon binding site; other site 710696008534 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 710696008535 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 710696008536 homotrimer interaction site [polypeptide binding]; other site 710696008537 zinc binding site [ion binding]; other site 710696008538 CDP-binding sites; other site 710696008539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696008540 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 710696008541 NAD(P) binding site [chemical binding]; other site 710696008542 active site 710696008543 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 710696008544 substrate binding site; other site 710696008545 dimer interface; other site 710696008546 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 710696008547 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710696008548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696008549 active site 710696008550 phosphorylation site [posttranslational modification] 710696008551 intermolecular recognition site; other site 710696008552 dimerization interface [polypeptide binding]; other site 710696008553 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710696008554 DNA binding site [nucleotide binding] 710696008555 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 710696008556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710696008557 dimer interface [polypeptide binding]; other site 710696008558 phosphorylation site [posttranslational modification] 710696008559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696008560 ATP binding site [chemical binding]; other site 710696008561 Mg2+ binding site [ion binding]; other site 710696008562 G-X-G motif; other site 710696008563 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 710696008564 PhoU domain; Region: PhoU; pfam01895 710696008565 PhoU domain; Region: PhoU; pfam01895 710696008566 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710696008567 catalytic core [active] 710696008568 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 710696008569 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 710696008570 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 710696008571 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 710696008572 putative ADP-binding pocket [chemical binding]; other site 710696008573 Methyltransferase domain; Region: Methyltransf_18; pfam12847 710696008574 Cupin domain; Region: Cupin_2; cl17218 710696008575 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 710696008576 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 710696008577 putative active site [active] 710696008578 dimerization interface [polypeptide binding]; other site 710696008579 putative tRNAtyr binding site [nucleotide binding]; other site 710696008580 L-asparaginase II; Region: Asparaginase_II; pfam06089 710696008581 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710696008582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710696008583 non-specific DNA binding site [nucleotide binding]; other site 710696008584 salt bridge; other site 710696008585 sequence-specific DNA binding site [nucleotide binding]; other site 710696008586 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 710696008587 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 710696008588 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 710696008589 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 710696008590 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 710696008591 heme-binding site [chemical binding]; other site 710696008592 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 710696008593 Ubiquitin-like proteins; Region: UBQ; cl00155 710696008594 charged pocket; other site 710696008595 hydrophobic patch; other site 710696008596 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 710696008597 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710696008598 DNA binding site [nucleotide binding] 710696008599 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 710696008600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696008601 Coenzyme A binding pocket [chemical binding]; other site 710696008602 polyphosphate kinase; Provisional; Region: PRK05443 710696008603 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 710696008604 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 710696008605 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 710696008606 putative domain interface [polypeptide binding]; other site 710696008607 putative active site [active] 710696008608 catalytic site [active] 710696008609 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 710696008610 putative domain interface [polypeptide binding]; other site 710696008611 putative active site [active] 710696008612 catalytic site [active] 710696008613 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 710696008614 active site 710696008615 Ap6A binding site [chemical binding]; other site 710696008616 nudix motif; other site 710696008617 metal binding site [ion binding]; metal-binding site 710696008618 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 710696008619 catalytic core [active] 710696008620 PBP superfamily domain; Region: PBP_like_2; cl17296 710696008621 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 710696008622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696008623 dimer interface [polypeptide binding]; other site 710696008624 conserved gate region; other site 710696008625 putative PBP binding loops; other site 710696008626 ABC-ATPase subunit interface; other site 710696008627 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 710696008628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696008629 dimer interface [polypeptide binding]; other site 710696008630 conserved gate region; other site 710696008631 putative PBP binding loops; other site 710696008632 ABC-ATPase subunit interface; other site 710696008633 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 710696008634 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 710696008635 Walker A/P-loop; other site 710696008636 ATP binding site [chemical binding]; other site 710696008637 Q-loop/lid; other site 710696008638 ABC transporter signature motif; other site 710696008639 Walker B; other site 710696008640 D-loop; other site 710696008641 H-loop/switch region; other site 710696008642 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 710696008643 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 710696008644 integrase; Provisional; Region: int; PHA02601 710696008645 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710696008646 active site 710696008647 DNA binding site [nucleotide binding] 710696008648 Int/Topo IB signature motif; other site 710696008649 Helix-turn-helix domain; Region: HTH_17; pfam12728 710696008650 Helix-turn-helix domain; Region: HTH_28; pfam13518 710696008651 Winged helix-turn helix; Region: HTH_29; pfam13551 710696008652 Homeodomain-like domain; Region: HTH_32; pfam13565 710696008653 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 710696008654 Integrase core domain; Region: rve; pfam00665 710696008655 Integrase core domain; Region: rve_3; pfam13683 710696008656 toxin-antitoxin system, toxin component, Txe/YoeB family; Region: toxin_Txe_YoeB; TIGR02116 710696008657 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 710696008658 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 710696008659 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 710696008660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696008661 Walker A/P-loop; other site 710696008662 ATP binding site [chemical binding]; other site 710696008663 Q-loop/lid; other site 710696008664 ABC transporter signature motif; other site 710696008665 Walker B; other site 710696008666 D-loop; other site 710696008667 H-loop/switch region; other site 710696008668 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 710696008669 catalytic residues [active] 710696008670 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 710696008671 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 710696008672 Glutaredoxin-like domain (DUF836); Region: DUF836; cl17650 710696008673 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 710696008674 putative homodimer interface [polypeptide binding]; other site 710696008675 putative homotetramer interface [polypeptide binding]; other site 710696008676 putative allosteric switch controlling residues; other site 710696008677 putative metal binding site [ion binding]; other site 710696008678 putative homodimer-homodimer interface [polypeptide binding]; other site 710696008679 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 710696008680 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 710696008681 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710696008682 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710696008683 motif II; other site 710696008684 Uncharacterized conserved protein [Function unknown]; Region: COG3350 710696008685 Putative zinc-finger; Region: zf-HC2; pfam13490 710696008686 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 710696008687 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 710696008688 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 710696008689 Multicopper oxidase; Region: Cu-oxidase; pfam00394 710696008690 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 710696008691 Predicted membrane protein [Function unknown]; Region: COG3462 710696008692 Short C-terminal domain; Region: SHOCT; pfam09851 710696008693 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710696008694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696008695 active site 710696008696 phosphorylation site [posttranslational modification] 710696008697 intermolecular recognition site; other site 710696008698 dimerization interface [polypeptide binding]; other site 710696008699 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710696008700 DNA binding site [nucleotide binding] 710696008701 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710696008702 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710696008703 dimerization interface [polypeptide binding]; other site 710696008704 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710696008705 dimer interface [polypeptide binding]; other site 710696008706 phosphorylation site [posttranslational modification] 710696008707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696008708 ATP binding site [chemical binding]; other site 710696008709 Mg2+ binding site [ion binding]; other site 710696008710 G-X-G motif; other site 710696008711 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 710696008712 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710696008713 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710696008714 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710696008715 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710696008716 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 710696008717 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 710696008718 interchain domain interface [polypeptide binding]; other site 710696008719 heme bL binding site [chemical binding]; other site 710696008720 intrachain domain interface; other site 710696008721 heme bH binding site [chemical binding]; other site 710696008722 Qo binding site; other site 710696008723 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 710696008724 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710696008725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696008726 active site 710696008727 phosphorylation site [posttranslational modification] 710696008728 intermolecular recognition site; other site 710696008729 dimerization interface [polypeptide binding]; other site 710696008730 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710696008731 DNA binding residues [nucleotide binding] 710696008732 dimerization interface [polypeptide binding]; other site 710696008733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710696008734 Histidine kinase; Region: HisKA_3; pfam07730 710696008735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696008736 ATP binding site [chemical binding]; other site 710696008737 Mg2+ binding site [ion binding]; other site 710696008738 G-X-G motif; other site 710696008739 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 710696008740 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710696008741 DNA binding residues [nucleotide binding] 710696008742 high affinity sulphate transporter 1; Region: sulP; TIGR00815 710696008743 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 710696008744 Sulfate transporter family; Region: Sulfate_transp; pfam00916 710696008745 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 710696008746 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 710696008747 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710696008748 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 710696008749 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710696008750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696008751 active site 710696008752 phosphorylation site [posttranslational modification] 710696008753 intermolecular recognition site; other site 710696008754 dimerization interface [polypeptide binding]; other site 710696008755 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710696008756 DNA binding site [nucleotide binding] 710696008757 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710696008758 HAMP domain; Region: HAMP; pfam00672 710696008759 dimerization interface [polypeptide binding]; other site 710696008760 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710696008761 dimer interface [polypeptide binding]; other site 710696008762 phosphorylation site [posttranslational modification] 710696008763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696008764 ATP binding site [chemical binding]; other site 710696008765 Mg2+ binding site [ion binding]; other site 710696008766 G-X-G motif; other site 710696008767 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 710696008768 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 710696008769 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 710696008770 hydrogenase 4 subunit F; Validated; Region: PRK06458 710696008771 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710696008772 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 710696008773 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 710696008774 hydrogenase 4 subunit B; Validated; Region: PRK06521 710696008775 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710696008776 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 710696008777 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696008778 dimerization interface [polypeptide binding]; other site 710696008779 putative DNA binding site [nucleotide binding]; other site 710696008780 putative Zn2+ binding site [ion binding]; other site 710696008781 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710696008782 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710696008783 dimer interface [polypeptide binding]; other site 710696008784 phosphorylation site [posttranslational modification] 710696008785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696008786 ATP binding site [chemical binding]; other site 710696008787 Mg2+ binding site [ion binding]; other site 710696008788 G-X-G motif; other site 710696008789 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710696008790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696008791 active site 710696008792 phosphorylation site [posttranslational modification] 710696008793 intermolecular recognition site; other site 710696008794 dimerization interface [polypeptide binding]; other site 710696008795 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710696008796 DNA binding site [nucleotide binding] 710696008797 Predicted membrane protein [Function unknown]; Region: COG3462 710696008798 Short C-terminal domain; Region: SHOCT; pfam09851 710696008799 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710696008800 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710696008801 active site 2 [active] 710696008802 active site 1 [active] 710696008803 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 710696008804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710696008805 motif II; other site 710696008806 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 710696008807 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 710696008808 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710696008809 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710696008810 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 710696008811 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 710696008812 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710696008813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696008814 S-adenosylmethionine binding site [chemical binding]; other site 710696008815 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 710696008816 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 710696008817 Walker A/P-loop; other site 710696008818 ATP binding site [chemical binding]; other site 710696008819 Q-loop/lid; other site 710696008820 ABC transporter signature motif; other site 710696008821 Walker B; other site 710696008822 D-loop; other site 710696008823 H-loop/switch region; other site 710696008824 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 710696008825 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 710696008826 Walker A/P-loop; other site 710696008827 ATP binding site [chemical binding]; other site 710696008828 Q-loop/lid; other site 710696008829 ABC transporter signature motif; other site 710696008830 Walker B; other site 710696008831 D-loop; other site 710696008832 H-loop/switch region; other site 710696008833 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 710696008834 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 710696008835 TM-ABC transporter signature motif; other site 710696008836 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710696008837 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 710696008838 TM-ABC transporter signature motif; other site 710696008839 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 710696008840 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 710696008841 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710696008842 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710696008843 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710696008844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710696008845 DNA-binding site [nucleotide binding]; DNA binding site 710696008846 FCD domain; Region: FCD; pfam07729 710696008847 Amidohydrolase; Region: Amidohydro_4; pfam13147 710696008848 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 710696008849 active site 710696008850 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 710696008851 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696008852 putative ADP-binding pocket [chemical binding]; other site 710696008853 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 710696008854 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696008855 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 710696008856 active site 710696008857 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 710696008858 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 710696008859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696008860 catalytic residue [active] 710696008861 DsrE/DsrF-like family; Region: DrsE; cl00672 710696008862 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 710696008863 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 710696008864 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 710696008865 NAD binding site [chemical binding]; other site 710696008866 substrate binding site [chemical binding]; other site 710696008867 catalytic Zn binding site [ion binding]; other site 710696008868 tetramer interface [polypeptide binding]; other site 710696008869 structural Zn binding site [ion binding]; other site 710696008870 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710696008871 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 710696008872 DNA binding residues [nucleotide binding] 710696008873 CsbD-like; Region: CsbD; pfam05532 710696008874 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 710696008875 Cation efflux family; Region: Cation_efflux; cl00316 710696008876 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 710696008877 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 710696008878 DNA binding site [nucleotide binding] 710696008879 active site 710696008880 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710696008881 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696008882 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 710696008883 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 710696008884 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 710696008885 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 710696008886 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 710696008887 DNA binding site [nucleotide binding] 710696008888 active site 710696008889 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 710696008890 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696008891 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710696008892 DNA binding residues [nucleotide binding] 710696008893 hypothetical protein; Provisional; Region: PRK07945 710696008894 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 710696008895 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 710696008896 active site 710696008897 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710696008898 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 710696008899 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 710696008900 FAD binding pocket [chemical binding]; other site 710696008901 FAD binding motif [chemical binding]; other site 710696008902 phosphate binding motif [ion binding]; other site 710696008903 beta-alpha-beta structure motif; other site 710696008904 NAD binding pocket [chemical binding]; other site 710696008905 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710696008906 catalytic loop [active] 710696008907 iron binding site [ion binding]; other site 710696008908 Fatty acid desaturase; Region: FA_desaturase; pfam00487 710696008909 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 710696008910 putative di-iron ligands [ion binding]; other site 710696008911 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 710696008912 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 710696008913 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 710696008914 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 710696008915 putative active site [active] 710696008916 putative FMN binding site [chemical binding]; other site 710696008917 putative substrate binding site [chemical binding]; other site 710696008918 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 710696008919 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 710696008920 dimer interface [polypeptide binding]; other site 710696008921 PYR/PP interface [polypeptide binding]; other site 710696008922 TPP binding site [chemical binding]; other site 710696008923 substrate binding site [chemical binding]; other site 710696008924 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 710696008925 Domain of unknown function; Region: EKR; pfam10371 710696008926 4Fe-4S binding domain; Region: Fer4_6; pfam12837 710696008927 4Fe-4S binding domain; Region: Fer4; pfam00037 710696008928 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 710696008929 TPP-binding site [chemical binding]; other site 710696008930 dimer interface [polypeptide binding]; other site 710696008931 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 710696008932 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710696008933 4Fe-4S binding domain; Region: Fer4; pfam00037 710696008934 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 710696008935 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710696008936 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 710696008937 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 710696008938 active site 710696008939 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 710696008940 active site 710696008941 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 710696008942 Uncharacterized conserved protein [Function unknown]; Region: COG2353 710696008943 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 710696008944 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 710696008945 putative active site [active] 710696008946 catalytic triad [active] 710696008947 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 710696008948 PA/protease or protease-like domain interface [polypeptide binding]; other site 710696008949 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 710696008950 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 710696008951 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710696008952 FeS/SAM binding site; other site 710696008953 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 710696008954 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 710696008955 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696008956 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710696008957 Walker A motif; other site 710696008958 ATP binding site [chemical binding]; other site 710696008959 Walker B motif; other site 710696008960 arginine finger; other site 710696008961 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 710696008962 PLD-like domain; Region: PLDc_2; pfam13091 710696008963 putative active site [active] 710696008964 catalytic site [active] 710696008965 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 710696008966 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 710696008967 ATP-binding site [chemical binding]; other site 710696008968 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 710696008969 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710696008970 ATP binding site [chemical binding]; other site 710696008971 putative Mg++ binding site [ion binding]; other site 710696008972 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710696008973 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 710696008974 nucleotide binding region [chemical binding]; other site 710696008975 ATP-binding site [chemical binding]; other site 710696008976 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 710696008977 putative homodimer interface [polypeptide binding]; other site 710696008978 putative active site [active] 710696008979 catalytic site [active] 710696008980 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710696008981 ATP-binding site [chemical binding]; other site 710696008982 TrwC relaxase; Region: TrwC; pfam08751 710696008983 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 710696008984 AAA domain; Region: AAA_30; pfam13604 710696008985 Family description; Region: UvrD_C_2; pfam13538 710696008986 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 710696008987 dimer interface [polypeptide binding]; other site 710696008988 active site 710696008989 nudix motif; other site 710696008990 ADP-ribose binding site [chemical binding]; other site 710696008991 metal binding site [ion binding]; metal-binding site 710696008992 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710696008993 NlpC/P60 family; Region: NLPC_P60; pfam00877 710696008994 AAA-like domain; Region: AAA_10; pfam12846 710696008995 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710696008996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710696008997 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710696008998 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710696008999 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710696009000 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710696009001 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 710696009002 GIY-YIG motif/motif A; other site 710696009003 active site 710696009004 catalytic site [active] 710696009005 metal binding site [ion binding]; metal-binding site 710696009006 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 710696009007 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 710696009008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696009009 Walker A motif; other site 710696009010 ATP binding site [chemical binding]; other site 710696009011 Walker B motif; other site 710696009012 arginine finger; other site 710696009013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 710696009014 Helix-turn-helix domain; Region: HTH_38; pfam13936 710696009015 Integrase core domain; Region: rve; pfam00665 710696009016 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 710696009017 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 710696009018 Walker A motif; other site 710696009019 ATP binding site [chemical binding]; other site 710696009020 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 710696009021 CHC2 zinc finger; Region: zf-CHC2; cl17510 710696009022 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 710696009023 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 710696009024 Helix-turn-helix domain; Region: HTH_17; cl17695 710696009025 Helix-turn-helix domain; Region: HTH_17; cl17695 710696009026 integrase; Provisional; Region: int; PHA02601 710696009027 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710696009028 active site 710696009029 Int/Topo IB signature motif; other site 710696009030 DNA binding site [nucleotide binding] 710696009031 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710696009032 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710696009033 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710696009034 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710696009035 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710696009036 substrate binding site [chemical binding]; other site 710696009037 oxyanion hole (OAH) forming residues; other site 710696009038 trimer interface [polypeptide binding]; other site 710696009039 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 710696009040 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 710696009041 acyl-activating enzyme (AAE) consensus motif; other site 710696009042 putative AMP binding site [chemical binding]; other site 710696009043 putative active site [active] 710696009044 putative CoA binding site [chemical binding]; other site 710696009045 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710696009046 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710696009047 NAD(P) binding site [chemical binding]; other site 710696009048 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710696009049 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710696009050 substrate binding site [chemical binding]; other site 710696009051 oxyanion hole (OAH) forming residues; other site 710696009052 trimer interface [polypeptide binding]; other site 710696009053 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710696009054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696009055 NAD(P) binding site [chemical binding]; other site 710696009056 active site 710696009057 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 710696009058 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710696009059 E3 interaction surface; other site 710696009060 lipoyl attachment site [posttranslational modification]; other site 710696009061 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 710696009062 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 710696009063 alpha subunit interface [polypeptide binding]; other site 710696009064 TPP binding site [chemical binding]; other site 710696009065 heterodimer interface [polypeptide binding]; other site 710696009066 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710696009067 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 710696009068 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 710696009069 tetramer interface [polypeptide binding]; other site 710696009070 TPP-binding site [chemical binding]; other site 710696009071 heterodimer interface [polypeptide binding]; other site 710696009072 phosphorylation loop region [posttranslational modification] 710696009073 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710696009074 active site 2 [active] 710696009075 active site 1 [active] 710696009076 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710696009077 active site 710696009078 catalytic site [active] 710696009079 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710696009080 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710696009081 active site 710696009082 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710696009083 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696009084 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 710696009085 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 710696009086 Walker A/P-loop; other site 710696009087 ATP binding site [chemical binding]; other site 710696009088 Q-loop/lid; other site 710696009089 ABC transporter signature motif; other site 710696009090 Walker B; other site 710696009091 D-loop; other site 710696009092 H-loop/switch region; other site 710696009093 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 710696009094 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 710696009095 Walker A/P-loop; other site 710696009096 ATP binding site [chemical binding]; other site 710696009097 Q-loop/lid; other site 710696009098 ABC transporter signature motif; other site 710696009099 Walker B; other site 710696009100 D-loop; other site 710696009101 H-loop/switch region; other site 710696009102 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710696009103 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 710696009104 TM-ABC transporter signature motif; other site 710696009105 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710696009106 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 710696009107 TM-ABC transporter signature motif; other site 710696009108 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 710696009109 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 710696009110 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710696009111 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710696009112 classical (c) SDRs; Region: SDR_c; cd05233 710696009113 NAD(P) binding site [chemical binding]; other site 710696009114 active site 710696009115 Restriction endonuclease; Region: Mrr_cat; pfam04471 710696009116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710696009117 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696009118 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710696009119 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696009120 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 710696009121 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 710696009122 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 710696009123 tricarballylate dehydrogenase; Validated; Region: PRK08274 710696009124 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710696009125 Isochorismatase family; Region: Isochorismatase; pfam00857 710696009126 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 710696009127 catalytic triad [active] 710696009128 conserved cis-peptide bond; other site 710696009129 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 710696009130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696009131 NAD(P) binding site [chemical binding]; other site 710696009132 active site 710696009133 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 710696009134 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710696009135 L-aspartate oxidase; Provisional; Region: PRK06175 710696009136 Predicted oxidoreductase [General function prediction only]; Region: COG3573 710696009137 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 710696009138 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 710696009139 tetramer interface [polypeptide binding]; other site 710696009140 active site 710696009141 Mg2+/Mn2+ binding site [ion binding]; other site 710696009142 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 710696009143 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 710696009144 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 710696009145 active site 710696009146 Fe binding site [ion binding]; other site 710696009147 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710696009148 active site 710696009149 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710696009150 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 710696009151 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710696009152 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710696009153 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710696009154 active site 710696009155 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 710696009156 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710696009157 TM-ABC transporter signature motif; other site 710696009158 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 710696009159 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 710696009160 Walker A/P-loop; other site 710696009161 ATP binding site [chemical binding]; other site 710696009162 Q-loop/lid; other site 710696009163 ABC transporter signature motif; other site 710696009164 Walker B; other site 710696009165 D-loop; other site 710696009166 H-loop/switch region; other site 710696009167 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 710696009168 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 710696009169 ligand binding site [chemical binding]; other site 710696009170 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 710696009171 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 710696009172 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710696009173 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710696009174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710696009175 DNA-binding site [nucleotide binding]; DNA binding site 710696009176 FCD domain; Region: FCD; pfam07729 710696009177 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 710696009178 Proline racemase; Region: Pro_racemase; pfam05544 710696009179 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 710696009180 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 710696009181 Walker A/P-loop; other site 710696009182 ATP binding site [chemical binding]; other site 710696009183 Q-loop/lid; other site 710696009184 ABC transporter signature motif; other site 710696009185 Walker B; other site 710696009186 D-loop; other site 710696009187 H-loop/switch region; other site 710696009188 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 710696009189 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 710696009190 Walker A/P-loop; other site 710696009191 ATP binding site [chemical binding]; other site 710696009192 Q-loop/lid; other site 710696009193 ABC transporter signature motif; other site 710696009194 Walker B; other site 710696009195 D-loop; other site 710696009196 H-loop/switch region; other site 710696009197 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 710696009198 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 710696009199 TM-ABC transporter signature motif; other site 710696009200 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710696009201 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 710696009202 TM-ABC transporter signature motif; other site 710696009203 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 710696009204 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 710696009205 dimerization interface [polypeptide binding]; other site 710696009206 ligand binding site [chemical binding]; other site 710696009207 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 710696009208 Proline racemase; Region: Pro_racemase; pfam05544 710696009209 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 710696009210 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 710696009211 inhibitor site; inhibition site 710696009212 active site 710696009213 dimer interface [polypeptide binding]; other site 710696009214 catalytic residue [active] 710696009215 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 710696009216 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710696009217 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 710696009218 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 710696009219 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710696009220 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 710696009221 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710696009222 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 710696009223 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 710696009224 dimer interface [polypeptide binding]; other site 710696009225 NADP binding site [chemical binding]; other site 710696009226 catalytic residues [active] 710696009227 Protein of unknown function (DUF521); Region: DUF521; pfam04412 710696009228 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 710696009229 substrate binding site [chemical binding]; other site 710696009230 ligand binding site [chemical binding]; other site 710696009231 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 710696009232 substrate binding site [chemical binding]; other site 710696009233 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 710696009234 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696009235 Coenzyme A binding pocket [chemical binding]; other site 710696009236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710696009237 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710696009238 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710696009239 active site 710696009240 4Fe-4S binding domain; Region: Fer4_5; pfam12801 710696009241 4Fe-4S binding domain; Region: Fer4_5; pfam12801 710696009242 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 710696009243 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 710696009244 hypothetical protein; Provisional; Region: PRK09256 710696009245 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 710696009246 threonine dehydratase; Provisional; Region: PRK08198 710696009247 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 710696009248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696009249 catalytic residue [active] 710696009250 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 710696009251 4-alpha-glucanotransferase; Provisional; Region: PRK14508 710696009252 hydroxyglutarate oxidase; Provisional; Region: PRK11728 710696009253 Predicted dehydrogenase [General function prediction only]; Region: COG0579 710696009254 Domain of unknown function (DUF305); Region: DUF305; pfam03713 710696009255 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710696009256 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710696009257 active site 710696009258 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 710696009259 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 710696009260 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 710696009261 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 710696009262 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 710696009263 TM-ABC transporter signature motif; other site 710696009264 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 710696009265 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 710696009266 Walker A/P-loop; other site 710696009267 ATP binding site [chemical binding]; other site 710696009268 Q-loop/lid; other site 710696009269 ABC transporter signature motif; other site 710696009270 Walker B; other site 710696009271 D-loop; other site 710696009272 H-loop/switch region; other site 710696009273 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 710696009274 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 710696009275 Walker A/P-loop; other site 710696009276 ATP binding site [chemical binding]; other site 710696009277 Q-loop/lid; other site 710696009278 ABC transporter signature motif; other site 710696009279 Walker B; other site 710696009280 D-loop; other site 710696009281 H-loop/switch region; other site 710696009282 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710696009283 MoaC_like Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: MaoC_like; cd03446 710696009284 homodimer interaction site [polypeptide binding]; other site 710696009285 putative active site [active] 710696009286 putative catalytic site [active] 710696009287 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710696009288 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710696009289 active site 710696009290 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710696009291 putative active site [active] 710696009292 putative substrate binding site [chemical binding]; other site 710696009293 ATP binding site [chemical binding]; other site 710696009294 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 710696009295 putative active site [active] 710696009296 putative catalytic site [active] 710696009297 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 710696009298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710696009299 NAD(P) binding site [chemical binding]; other site 710696009300 active site 710696009301 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710696009302 classical (c) SDRs; Region: SDR_c; cd05233 710696009303 NAD(P) binding site [chemical binding]; other site 710696009304 active site 710696009305 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 710696009306 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 710696009307 active site 710696009308 DNA binding site [nucleotide binding] 710696009309 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 710696009310 DNA binding site [nucleotide binding] 710696009311 glutathione synthetase; Provisional; Region: PRK12458 710696009312 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710696009313 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 710696009314 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 710696009315 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 710696009316 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 710696009317 catalytic site [active] 710696009318 active site 710696009319 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 710696009320 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710696009321 hydroxyglutarate oxidase; Provisional; Region: PRK11728 710696009322 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710696009323 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 710696009324 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696009325 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710696009326 Coenzyme A binding pocket [chemical binding]; other site 710696009327 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710696009328 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710696009329 active site 710696009330 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 710696009331 DNA binding residues [nucleotide binding] 710696009332 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 710696009333 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 710696009334 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 710696009335 dimerization interface [polypeptide binding]; other site 710696009336 putative ATP binding site [chemical binding]; other site 710696009337 amidophosphoribosyltransferase; Provisional; Region: PRK07847 710696009338 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 710696009339 active site 710696009340 tetramer interface [polypeptide binding]; other site 710696009341 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710696009342 active site 710696009343 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 710696009344 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 710696009345 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710696009346 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710696009347 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710696009348 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 710696009349 nodulation ABC transporter NodI; Provisional; Region: PRK13537 710696009350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696009351 Walker A/P-loop; other site 710696009352 ATP binding site [chemical binding]; other site 710696009353 Q-loop/lid; other site 710696009354 ABC transporter signature motif; other site 710696009355 Walker B; other site 710696009356 D-loop; other site 710696009357 H-loop/switch region; other site 710696009358 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710696009359 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710696009360 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710696009361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710696009362 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 710696009363 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 710696009364 metal ion-dependent adhesion site (MIDAS); other site 710696009365 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 710696009366 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 710696009367 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 710696009368 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 710696009369 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 710696009370 dimerization interface [polypeptide binding]; other site 710696009371 ATP binding site [chemical binding]; other site 710696009372 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 710696009373 dimerization interface [polypeptide binding]; other site 710696009374 ATP binding site [chemical binding]; other site 710696009375 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 710696009376 putative active site [active] 710696009377 catalytic triad [active] 710696009378 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 710696009379 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 710696009380 putative active site [active] 710696009381 putative metal binding site [ion binding]; other site 710696009382 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 710696009383 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 710696009384 ATP binding site [chemical binding]; other site 710696009385 active site 710696009386 substrate binding site [chemical binding]; other site 710696009387 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 710696009388 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 710696009389 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 710696009390 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 710696009391 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 710696009392 Part of AAA domain; Region: AAA_19; pfam13245 710696009393 Family description; Region: UvrD_C_2; pfam13538 710696009394 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 710696009395 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710696009396 active site 710696009397 nucleotide binding site [chemical binding]; other site 710696009398 HIGH motif; other site 710696009399 KMSKS motif; other site 710696009400 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 710696009401 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 710696009402 GDP-binding site [chemical binding]; other site 710696009403 ACT binding site; other site 710696009404 IMP binding site; other site 710696009405 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 710696009406 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 710696009407 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710696009408 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710696009409 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710696009410 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710696009411 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 710696009412 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710696009413 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 710696009414 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710696009415 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710696009416 ligand binding site [chemical binding]; other site 710696009417 flexible hinge region; other site 710696009418 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 710696009419 putative switch regulator; other site 710696009420 non-specific DNA interactions [nucleotide binding]; other site 710696009421 DNA binding site [nucleotide binding] 710696009422 sequence specific DNA binding site [nucleotide binding]; other site 710696009423 putative cAMP binding site [chemical binding]; other site 710696009424 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 710696009425 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 710696009426 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 710696009427 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 710696009428 dimerization domain swap beta strand [polypeptide binding]; other site 710696009429 regulatory protein interface [polypeptide binding]; other site 710696009430 active site 710696009431 regulatory phosphorylation site [posttranslational modification]; other site 710696009432 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 710696009433 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 710696009434 active site 710696009435 phosphorylation site [posttranslational modification] 710696009436 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 710696009437 active site 710696009438 P-loop; other site 710696009439 phosphorylation site [posttranslational modification] 710696009440 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 710696009441 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 710696009442 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 710696009443 putative substrate binding site [chemical binding]; other site 710696009444 putative ATP binding site [chemical binding]; other site 710696009445 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 710696009446 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 710696009447 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 710696009448 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710696009449 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 710696009450 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 710696009451 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 710696009452 active site 710696009453 intersubunit interface [polypeptide binding]; other site 710696009454 zinc binding site [ion binding]; other site 710696009455 Na+ binding site [ion binding]; other site 710696009456 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 710696009457 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710696009458 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 710696009459 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 710696009460 active site 710696009461 Dodecin; Region: Dodecin; pfam07311 710696009462 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 710696009463 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 710696009464 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 710696009465 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 710696009466 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 710696009467 Secretory lipase; Region: LIP; pfam03583 710696009468 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 710696009469 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 710696009470 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710696009471 active site 710696009472 short chain dehydrogenase; Provisional; Region: PRK08219 710696009473 classical (c) SDRs; Region: SDR_c; cd05233 710696009474 NAD(P) binding site [chemical binding]; other site 710696009475 active site 710696009476 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710696009477 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 710696009478 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 710696009479 putative catalytic site [active] 710696009480 putative phosphate binding site [ion binding]; other site 710696009481 active site 710696009482 metal binding site A [ion binding]; metal-binding site 710696009483 DNA binding site [nucleotide binding] 710696009484 putative AP binding site [nucleotide binding]; other site 710696009485 putative metal binding site B [ion binding]; other site 710696009486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696009487 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710696009488 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 710696009489 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 710696009490 DNA binding site [nucleotide binding] 710696009491 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 710696009492 AAA ATPase domain; Region: AAA_16; pfam13191 710696009493 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710696009494 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 710696009495 structural tetrad; other site 710696009496 FOG: WD40 repeat [General function prediction only]; Region: COG2319 710696009497 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 710696009498 structural tetrad; other site 710696009499 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 710696009500 Clp amino terminal domain; Region: Clp_N; pfam02861 710696009501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696009502 Walker A motif; other site 710696009503 ATP binding site [chemical binding]; other site 710696009504 Walker B motif; other site 710696009505 arginine finger; other site 710696009506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710696009507 Walker A motif; other site 710696009508 ATP binding site [chemical binding]; other site 710696009509 Walker B motif; other site 710696009510 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 710696009511 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 710696009512 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710696009513 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 710696009514 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 710696009515 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710696009516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 710696009517 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 710696009518 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 710696009519 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 710696009520 active site 710696009521 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710696009522 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 710696009523 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710696009524 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 710696009525 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 710696009526 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 710696009527 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 710696009528 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 710696009529 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710696009530 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 710696009531 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710696009532 Walker A/P-loop; other site 710696009533 ATP binding site [chemical binding]; other site 710696009534 Q-loop/lid; other site 710696009535 ABC transporter signature motif; other site 710696009536 Walker B; other site 710696009537 D-loop; other site 710696009538 H-loop/switch region; other site 710696009539 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696009540 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710696009541 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 710696009542 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 710696009543 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 710696009544 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 710696009545 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 710696009546 active site 710696009547 homodimer interface [polypeptide binding]; other site 710696009548 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 710696009549 DNA binding residues [nucleotide binding] 710696009550 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710696009551 putative dimer interface [polypeptide binding]; other site 710696009552 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 710696009553 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 710696009554 HSP70 interaction site [polypeptide binding]; other site 710696009555 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 710696009556 substrate binding site [polypeptide binding]; other site 710696009557 dimer interface [polypeptide binding]; other site 710696009558 GrpE; Region: GrpE; pfam01025 710696009559 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 710696009560 dimer interface [polypeptide binding]; other site 710696009561 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 710696009562 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 710696009563 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 710696009564 nucleotide binding site [chemical binding]; other site 710696009565 NEF interaction site [polypeptide binding]; other site 710696009566 SBD interface [polypeptide binding]; other site 710696009567 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 710696009568 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 710696009569 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 710696009570 heme binding site [chemical binding]; other site 710696009571 ferroxidase pore; other site 710696009572 ferroxidase diiron center [ion binding]; other site 710696009573 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710696009574 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710696009575 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 710696009576 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 710696009577 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 710696009578 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 710696009579 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710696009580 putative DNA binding site [nucleotide binding]; other site 710696009581 putative Zn2+ binding site [ion binding]; other site 710696009582 AsnC family; Region: AsnC_trans_reg; pfam01037 710696009583 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 710696009584 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710696009585 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710696009586 catalytic residue [active] 710696009587 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 710696009588 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 710696009589 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 710696009590 catalytic residues [active] 710696009591 Protein of unknown function (DUF419); Region: DUF419; pfam04237 710696009592 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 710696009593 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 710696009594 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 710696009595 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710696009596 aminotransferase; Validated; Region: PRK07046 710696009597 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710696009598 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710696009599 catalytic residue [active] 710696009600 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710696009601 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710696009602 phosphate binding site [ion binding]; other site 710696009603 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 710696009604 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 710696009605 NAD(P) binding site [chemical binding]; other site 710696009606 LDH/MDH dimer interface [polypeptide binding]; other site 710696009607 substrate binding site [chemical binding]; other site 710696009608 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696009609 WHG domain; Region: WHG; pfam13305 710696009610 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710696009611 OsmC-like protein; Region: OsmC; pfam02566 710696009612 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 710696009613 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 710696009614 aminotransferase AlaT; Validated; Region: PRK09265 710696009615 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710696009616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696009617 homodimer interface [polypeptide binding]; other site 710696009618 catalytic residue [active] 710696009619 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 710696009620 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710696009621 catalytic core [active] 710696009622 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 710696009623 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710696009624 Walker A/P-loop; other site 710696009625 ATP binding site [chemical binding]; other site 710696009626 Q-loop/lid; other site 710696009627 ABC transporter signature motif; other site 710696009628 Walker B; other site 710696009629 D-loop; other site 710696009630 H-loop/switch region; other site 710696009631 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 710696009632 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 710696009633 Walker A/P-loop; other site 710696009634 ATP binding site [chemical binding]; other site 710696009635 Q-loop/lid; other site 710696009636 ABC transporter signature motif; other site 710696009637 Walker B; other site 710696009638 D-loop; other site 710696009639 H-loop/switch region; other site 710696009640 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 710696009641 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 710696009642 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 710696009643 pyruvate phosphate dikinase; Provisional; Region: PRK09279 710696009644 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 710696009645 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 710696009646 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 710696009647 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710696009648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696009649 active site 710696009650 phosphorylation site [posttranslational modification] 710696009651 intermolecular recognition site; other site 710696009652 dimerization interface [polypeptide binding]; other site 710696009653 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710696009654 DNA binding residues [nucleotide binding] 710696009655 dimerization interface [polypeptide binding]; other site 710696009656 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710696009657 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 710696009658 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710696009659 Histidine kinase; Region: HisKA_3; pfam07730 710696009660 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 710696009661 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 710696009662 imidazolonepropionase; Provisional; Region: PRK14085 710696009663 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 710696009664 active site 710696009665 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 710696009666 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710696009667 active site 710696009668 allantoate amidohydrolase; Reviewed; Region: PRK09290 710696009669 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 710696009670 active site 710696009671 metal binding site [ion binding]; metal-binding site 710696009672 dimer interface [polypeptide binding]; other site 710696009673 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 710696009674 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 710696009675 putative deacylase active site [active] 710696009676 urocanate hydratase; Provisional; Region: PRK05414 710696009677 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 710696009678 active sites [active] 710696009679 tetramer interface [polypeptide binding]; other site 710696009680 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710696009681 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 710696009682 Bacterial transcriptional regulator; Region: IclR; pfam01614 710696009683 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 710696009684 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 710696009685 NAD(P) binding site [chemical binding]; other site 710696009686 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 710696009687 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710696009688 Histidine kinase; Region: HisKA_3; pfam07730 710696009689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696009690 ATP binding site [chemical binding]; other site 710696009691 G-X-G motif; other site 710696009692 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710696009693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696009694 active site 710696009695 phosphorylation site [posttranslational modification] 710696009696 intermolecular recognition site; other site 710696009697 dimerization interface [polypeptide binding]; other site 710696009698 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710696009699 DNA binding residues [nucleotide binding] 710696009700 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 710696009701 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 710696009702 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 710696009703 active site 710696009704 metal binding site [ion binding]; metal-binding site 710696009705 Bacterial PH domain; Region: DUF304; pfam03703 710696009706 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 710696009707 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 710696009708 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 710696009709 active site 710696009710 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 710696009711 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 710696009712 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 710696009713 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 710696009714 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710696009715 HAMP domain; Region: HAMP; pfam00672 710696009716 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710696009717 dimer interface [polypeptide binding]; other site 710696009718 phosphorylation site [posttranslational modification] 710696009719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696009720 ATP binding site [chemical binding]; other site 710696009721 Mg2+ binding site [ion binding]; other site 710696009722 G-X-G motif; other site 710696009723 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710696009724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696009725 active site 710696009726 phosphorylation site [posttranslational modification] 710696009727 intermolecular recognition site; other site 710696009728 dimerization interface [polypeptide binding]; other site 710696009729 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710696009730 DNA binding site [nucleotide binding] 710696009731 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 710696009732 DEAD-like helicases superfamily; Region: DEXDc; smart00487 710696009733 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710696009734 ATP binding site [chemical binding]; other site 710696009735 putative Mg++ binding site [ion binding]; other site 710696009736 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710696009737 nucleotide binding region [chemical binding]; other site 710696009738 ATP-binding site [chemical binding]; other site 710696009739 NAD synthetase; Reviewed; Region: nadE; PRK02628 710696009740 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 710696009741 multimer interface [polypeptide binding]; other site 710696009742 active site 710696009743 catalytic triad [active] 710696009744 protein interface 1 [polypeptide binding]; other site 710696009745 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 710696009746 homodimer interface [polypeptide binding]; other site 710696009747 NAD binding pocket [chemical binding]; other site 710696009748 ATP binding pocket [chemical binding]; other site 710696009749 Mg binding site [ion binding]; other site 710696009750 active-site loop [active] 710696009751 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 710696009752 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 710696009753 gating phenylalanine in ion channel; other site 710696009754 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 710696009755 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 710696009756 substrate-cofactor binding pocket; other site 710696009757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696009758 catalytic residue [active] 710696009759 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 710696009760 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710696009761 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 710696009762 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710696009763 NAD(P) binding site [chemical binding]; other site 710696009764 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 710696009765 metal binding site 2 [ion binding]; metal-binding site 710696009766 putative DNA binding helix; other site 710696009767 metal binding site 1 [ion binding]; metal-binding site 710696009768 dimer interface [polypeptide binding]; other site 710696009769 structural Zn2+ binding site [ion binding]; other site 710696009770 putative acetyltransferase; Provisional; Region: PRK03624 710696009771 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696009772 Coenzyme A binding pocket [chemical binding]; other site 710696009773 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 710696009774 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 710696009775 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 710696009776 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 710696009777 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 710696009778 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710696009779 ATP binding site [chemical binding]; other site 710696009780 putative Mg++ binding site [ion binding]; other site 710696009781 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710696009782 nucleotide binding region [chemical binding]; other site 710696009783 ATP-binding site [chemical binding]; other site 710696009784 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 710696009785 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710696009786 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 710696009787 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 710696009788 active site 710696009789 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710696009790 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 710696009791 NAD(P) binding site [chemical binding]; other site 710696009792 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 710696009793 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 710696009794 nucleotide binding site/active site [active] 710696009795 HIT family signature motif; other site 710696009796 catalytic residue [active] 710696009797 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 710696009798 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 710696009799 active site 710696009800 FMN binding site [chemical binding]; other site 710696009801 2,4-decadienoyl-CoA binding site; other site 710696009802 catalytic residue [active] 710696009803 4Fe-4S cluster binding site [ion binding]; other site 710696009804 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 710696009805 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 710696009806 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 710696009807 Bacterial PH domain; Region: DUF304; cl01348 710696009808 Predicted membrane protein [Function unknown]; Region: COG3428 710696009809 Bacterial PH domain; Region: DUF304; pfam03703 710696009810 Bacterial PH domain; Region: DUF304; pfam03703 710696009811 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 710696009812 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 710696009813 putative dimer interface [polypeptide binding]; other site 710696009814 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 710696009815 aromatic arch; other site 710696009816 DCoH dimer interaction site [polypeptide binding]; other site 710696009817 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 710696009818 DCoH tetramer interaction site [polypeptide binding]; other site 710696009819 substrate binding site [chemical binding]; other site 710696009820 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 710696009821 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 710696009822 PAS fold; Region: PAS; pfam00989 710696009823 PAS domain; Region: PAS; smart00091 710696009824 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710696009825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710696009826 ATP binding site [chemical binding]; other site 710696009827 Mg2+ binding site [ion binding]; other site 710696009828 G-X-G motif; other site 710696009829 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 710696009830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710696009831 active site 710696009832 phosphorylation site [posttranslational modification] 710696009833 intermolecular recognition site; other site 710696009834 dimerization interface [polypeptide binding]; other site 710696009835 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 710696009836 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 710696009837 trimer interface [polypeptide binding]; other site 710696009838 putative metal binding site [ion binding]; other site 710696009839 MarR family; Region: MarR_2; cl17246 710696009840 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710696009841 aspartate aminotransferase; Provisional; Region: PRK05764 710696009842 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710696009843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696009844 homodimer interface [polypeptide binding]; other site 710696009845 catalytic residue [active] 710696009846 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710696009847 hydrophobic ligand binding site; other site 710696009848 formate transporter FocA; Region: formate_focA; TIGR04060 710696009849 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 710696009850 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 710696009851 Moco binding site; other site 710696009852 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 710696009853 metal coordination site [ion binding]; other site 710696009854 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710696009855 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 710696009856 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 710696009857 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 710696009858 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 710696009859 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 710696009860 metal binding site [ion binding]; metal-binding site 710696009861 dimer interface [polypeptide binding]; other site 710696009862 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 710696009863 metal binding site 2 [ion binding]; metal-binding site 710696009864 putative DNA binding helix; other site 710696009865 metal binding site 1 [ion binding]; metal-binding site 710696009866 dimer interface [polypeptide binding]; other site 710696009867 structural Zn2+ binding site [ion binding]; other site 710696009868 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 710696009869 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 710696009870 tetramer interface [polypeptide binding]; other site 710696009871 heme binding pocket [chemical binding]; other site 710696009872 NADPH binding site [chemical binding]; other site 710696009873 Protein of unknown function (DUF466); Region: DUF466; pfam04328 710696009874 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 710696009875 Carbon starvation protein CstA; Region: CstA; pfam02554 710696009876 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 710696009877 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 710696009878 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710696009879 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 710696009880 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 710696009881 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 710696009882 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 710696009883 Walker A/P-loop; other site 710696009884 ATP binding site [chemical binding]; other site 710696009885 Q-loop/lid; other site 710696009886 ABC transporter signature motif; other site 710696009887 Walker B; other site 710696009888 D-loop; other site 710696009889 H-loop/switch region; other site 710696009890 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 710696009891 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 710696009892 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 710696009893 dimer interface [polypeptide binding]; other site 710696009894 catalytic triad [active] 710696009895 peroxidatic and resolving cysteines [active] 710696009896 glycerol kinase; Provisional; Region: glpK; PRK00047 710696009897 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 710696009898 N- and C-terminal domain interface [polypeptide binding]; other site 710696009899 active site 710696009900 MgATP binding site [chemical binding]; other site 710696009901 catalytic site [active] 710696009902 metal binding site [ion binding]; metal-binding site 710696009903 putative homotetramer interface [polypeptide binding]; other site 710696009904 glycerol binding site [chemical binding]; other site 710696009905 homodimer interface [polypeptide binding]; other site 710696009906 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 710696009907 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 710696009908 hydroxyglutarate oxidase; Provisional; Region: PRK11728 710696009909 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 710696009910 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710696009911 ligand binding site [chemical binding]; other site 710696009912 flexible hinge region; other site 710696009913 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 710696009914 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 710696009915 metal binding triad; other site 710696009916 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 710696009917 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 710696009918 active site 710696009919 catalytic site [active] 710696009920 substrate binding site [chemical binding]; other site 710696009921 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 710696009922 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 710696009923 putative DNA binding site [nucleotide binding]; other site 710696009924 catalytic residue [active] 710696009925 putative H2TH interface [polypeptide binding]; other site 710696009926 putative catalytic residues [active] 710696009927 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710696009928 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710696009929 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 710696009930 ATP binding site [chemical binding]; other site 710696009931 putative Mg++ binding site [ion binding]; other site 710696009932 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710696009933 nucleotide binding region [chemical binding]; other site 710696009934 ATP-binding site [chemical binding]; other site 710696009935 DEAD/H associated; Region: DEAD_assoc; pfam08494 710696009936 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 710696009937 RibD C-terminal domain; Region: RibD_C; cl17279 710696009938 FOG: CBS domain [General function prediction only]; Region: COG0517 710696009939 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 710696009940 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 710696009941 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 710696009942 SNF2 Helicase protein; Region: DUF3670; pfam12419 710696009943 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710696009944 ATP binding site [chemical binding]; other site 710696009945 putative Mg++ binding site [ion binding]; other site 710696009946 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710696009947 nucleotide binding region [chemical binding]; other site 710696009948 ATP-binding site [chemical binding]; other site 710696009949 Uncharacterized conserved protein [Function unknown]; Region: COG4279 710696009950 SWIM zinc finger; Region: SWIM; pfam04434 710696009951 salicylate hydroxylase; Provisional; Region: PRK08163 710696009952 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710696009953 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710696009954 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710696009955 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 710696009956 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 710696009957 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 710696009958 Cupin domain; Region: Cupin_2; cl17218 710696009959 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710696009960 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 710696009961 Bacterial transcriptional regulator; Region: IclR; pfam01614 710696009962 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710696009963 ATP binding site [chemical binding]; other site 710696009964 putative Mg++ binding site [ion binding]; other site 710696009965 helicase superfamily c-terminal domain; Region: HELICc; smart00490 710696009966 nucleotide binding region [chemical binding]; other site 710696009967 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 710696009968 Predicted transcriptional regulators [Transcription]; Region: COG1695 710696009969 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 710696009970 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 710696009971 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 710696009972 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 710696009973 active site 710696009974 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 710696009975 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 710696009976 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 710696009977 active site 710696009978 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 710696009979 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 710696009980 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710696009981 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 710696009982 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 710696009983 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 710696009984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710696009985 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 710696009986 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710696009987 Walker A/P-loop; other site 710696009988 ATP binding site [chemical binding]; other site 710696009989 Q-loop/lid; other site 710696009990 ABC transporter signature motif; other site 710696009991 Walker B; other site 710696009992 D-loop; other site 710696009993 H-loop/switch region; other site 710696009994 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710696009995 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 710696009996 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710696009997 Walker A/P-loop; other site 710696009998 ATP binding site [chemical binding]; other site 710696009999 Q-loop/lid; other site 710696010000 ABC transporter signature motif; other site 710696010001 Walker B; other site 710696010002 D-loop; other site 710696010003 H-loop/switch region; other site 710696010004 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710696010005 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 710696010006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696010007 dimer interface [polypeptide binding]; other site 710696010008 conserved gate region; other site 710696010009 putative PBP binding loops; other site 710696010010 ABC-ATPase subunit interface; other site 710696010011 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 710696010012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696010013 dimer interface [polypeptide binding]; other site 710696010014 conserved gate region; other site 710696010015 putative PBP binding loops; other site 710696010016 ABC-ATPase subunit interface; other site 710696010017 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 710696010018 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 710696010019 endonuclease IV; Provisional; Region: PRK01060 710696010020 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 710696010021 AP (apurinic/apyrimidinic) site pocket; other site 710696010022 DNA interaction; other site 710696010023 Metal-binding active site; metal-binding site 710696010024 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710696010025 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 710696010026 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710696010027 FAD binding domain; Region: FAD_binding_2; pfam00890 710696010028 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710696010029 active site 710696010030 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 710696010031 Melibiase; Region: Melibiase; pfam02065 710696010032 DNA polymerase IV; Validated; Region: PRK03352 710696010033 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 710696010034 active site 710696010035 DNA binding site [nucleotide binding] 710696010036 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 710696010037 CHRD domain; Region: CHRD; pfam07452 710696010038 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 710696010039 putative catalytic site [active] 710696010040 putative phosphate binding site [ion binding]; other site 710696010041 putative metal binding site [ion binding]; other site 710696010042 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 710696010043 synthetase active site [active] 710696010044 NTP binding site [chemical binding]; other site 710696010045 metal binding site [ion binding]; metal-binding site 710696010046 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 710696010047 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 710696010048 FAD binding domain; Region: FAD_binding_4; pfam01565 710696010049 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710696010050 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 710696010051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696010052 S-adenosylmethionine binding site [chemical binding]; other site 710696010053 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 710696010054 putative homotetramer interface [polypeptide binding]; other site 710696010055 putative homodimer interface [polypeptide binding]; other site 710696010056 putative allosteric switch controlling residues; other site 710696010057 putative metal binding site [ion binding]; other site 710696010058 putative homodimer-homodimer interface [polypeptide binding]; other site 710696010059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710696010060 S-adenosylmethionine binding site [chemical binding]; other site 710696010061 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 710696010062 MMPL family; Region: MMPL; pfam03176 710696010063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710696010064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696010065 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 710696010066 Fe-S cluster binding site [ion binding]; other site 710696010067 DNA binding site [nucleotide binding] 710696010068 active site 710696010069 Methyltransferase domain; Region: Methyltransf_24; pfam13578 710696010070 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 710696010071 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696010072 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710696010073 DNA binding residues [nucleotide binding] 710696010074 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 710696010075 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 710696010076 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 710696010077 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 710696010078 active site 710696010079 nucleophile elbow; other site 710696010080 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 710696010081 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710696010082 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710696010083 active site 710696010084 metal binding site [ion binding]; metal-binding site 710696010085 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 710696010086 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710696010087 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710696010088 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710696010089 active site 710696010090 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710696010091 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 710696010092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696010093 Coenzyme A binding pocket [chemical binding]; other site 710696010094 Cupin domain; Region: Cupin_2; cl17218 710696010095 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 710696010096 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710696010097 NADP binding site [chemical binding]; other site 710696010098 dimer interface [polypeptide binding]; other site 710696010099 PemK-like protein; Region: PemK; pfam02452 710696010100 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710696010101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710696010102 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710696010103 Cupin domain; Region: Cupin_2; pfam07883 710696010104 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 710696010105 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 710696010106 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 710696010107 active site 710696010108 catalytic residues [active] 710696010109 DNA binding site [nucleotide binding] 710696010110 Int/Topo IB signature motif; other site 710696010111 putative transposase OrfB; Reviewed; Region: PHA02517 710696010112 HTH-like domain; Region: HTH_21; pfam13276 710696010113 Integrase core domain; Region: rve; pfam00665 710696010114 Integrase core domain; Region: rve_3; pfam13683 710696010115 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 710696010116 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710696010117 active site 710696010118 DNA binding site [nucleotide binding] 710696010119 Int/Topo IB signature motif; other site 710696010120 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 710696010121 nudix motif; other site 710696010122 Protein of unknown function (DUF429); Region: DUF429; pfam04250 710696010123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710696010124 Coenzyme A binding pocket [chemical binding]; other site 710696010125 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 710696010126 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710696010127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 710696010128 Transposase; Region: DDE_Tnp_ISL3; pfam01610 710696010129 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 710696010130 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 710696010131 active site 710696010132 metal binding site [ion binding]; metal-binding site 710696010133 nudix motif; other site 710696010134 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 710696010135 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710696010136 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710696010137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 710696010138 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 710696010139 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 710696010140 malonyl-CoA binding site [chemical binding]; other site 710696010141 dimer interface [polypeptide binding]; other site 710696010142 active site 710696010143 product binding site; other site 710696010144 UbiA prenyltransferase family; Region: UbiA; pfam01040 710696010145 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 710696010146 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 710696010147 nucleotide binding site [chemical binding]; other site 710696010148 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 710696010149 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 710696010150 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 710696010151 active site 710696010152 DNA binding site [nucleotide binding] 710696010153 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 710696010154 DNA binding site [nucleotide binding] 710696010155 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 710696010156 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 710696010157 active site 710696010158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710696010159 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 710696010160 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710696010161 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710696010162 active site 710696010163 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 710696010164 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710696010165 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710696010166 active site 710696010167 ATP binding site [chemical binding]; other site 710696010168 substrate binding site [chemical binding]; other site 710696010169 activation loop (A-loop); other site 710696010170 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710696010171 Predicted GTPase [General function prediction only]; Region: COG2403 710696010172 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710696010173 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 710696010174 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710696010175 inhibitor-cofactor binding pocket; inhibition site 710696010176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696010177 catalytic residue [active] 710696010178 LabA_like proteins; Region: LabA_like; cd06167 710696010179 putative metal binding site [ion binding]; other site 710696010180 Uncharacterized conserved protein [Function unknown]; Region: COG1432 710696010181 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 710696010182 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 710696010183 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710696010184 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 710696010185 Soluble P-type ATPase [General function prediction only]; Region: COG4087 710696010186 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 710696010187 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 710696010188 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710696010189 active site residue [active] 710696010190 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 710696010191 putative homodimer interface [polypeptide binding]; other site 710696010192 putative homotetramer interface [polypeptide binding]; other site 710696010193 putative allosteric switch controlling residues; other site 710696010194 putative metal binding site [ion binding]; other site 710696010195 putative homodimer-homodimer interface [polypeptide binding]; other site 710696010196 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 710696010197 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 710696010198 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 710696010199 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710696010200 ERCC4 domain; Region: ERCC4; pfam02732 710696010201 Lsr2; Region: Lsr2; pfam11774 710696010202 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 710696010203 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 710696010204 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 710696010205 acyl-activating enzyme (AAE) consensus motif; other site 710696010206 putative AMP binding site [chemical binding]; other site 710696010207 putative active site [active] 710696010208 putative CoA binding site [chemical binding]; other site 710696010209 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 710696010210 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 710696010211 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 710696010212 putative active site [active] 710696010213 putative substrate binding site [chemical binding]; other site 710696010214 putative FMN binding site [chemical binding]; other site 710696010215 putative catalytic residues [active] 710696010216 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 710696010217 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 710696010218 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710696010219 Transcription factor WhiB; Region: Whib; pfam02467 710696010220 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710696010221 FAD binding domain; Region: FAD_binding_4; pfam01565 710696010222 Berberine and berberine like; Region: BBE; pfam08031 710696010223 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 710696010224 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710696010225 catalytic Zn binding site [ion binding]; other site 710696010226 NAD(P) binding site [chemical binding]; other site 710696010227 structural Zn binding site [ion binding]; other site 710696010228 Transposase; Region: HTH_Tnp_1; cl17663 710696010229 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 710696010230 CHAP domain; Region: CHAP; pfam05257 710696010231 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710696010232 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710696010233 SWIM zinc finger; Region: SWIM; pfam04434 710696010234 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 710696010235 metal ion-dependent adhesion site (MIDAS); other site 710696010236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710696010237 Coenzyme A binding pocket [chemical binding]; other site 710696010238 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 710696010239 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 710696010240 Catalytic site; other site 710696010241 threonine dehydratase; Reviewed; Region: PRK09224 710696010242 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 710696010243 tetramer interface [polypeptide binding]; other site 710696010244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696010245 catalytic residue [active] 710696010246 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 710696010247 putative Ile/Val binding site [chemical binding]; other site 710696010248 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 710696010249 putative Ile/Val binding site [chemical binding]; other site 710696010250 Peptidase M30; Region: Peptidase_M30; pfam10460 710696010251 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 710696010252 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 710696010253 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 710696010254 ACT domain; Region: ACT_6; pfam13740 710696010255 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 710696010256 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 710696010257 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 710696010258 putative active site [active] 710696010259 Zn binding site [ion binding]; other site 710696010260 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 710696010261 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 710696010262 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710696010263 TrkA-C domain; Region: TrkA_C; pfam02080 710696010264 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710696010265 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710696010266 active site residue [active] 710696010267 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710696010268 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 710696010269 inhibitor-cofactor binding pocket; inhibition site 710696010270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696010271 catalytic residue [active] 710696010272 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710696010273 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710696010274 EamA-like transporter family; Region: EamA; pfam00892 710696010275 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 710696010276 EamA-like transporter family; Region: EamA; pfam00892 710696010277 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710696010278 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710696010279 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 710696010280 dimerization interface [polypeptide binding]; other site 710696010281 YhhN-like protein; Region: YhhN; pfam07947 710696010282 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 710696010283 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 710696010284 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 710696010285 lipoyl synthase; Provisional; Region: PRK05481 710696010286 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710696010287 FeS/SAM binding site; other site 710696010288 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 710696010289 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 710696010290 dimer interface [polypeptide binding]; other site 710696010291 active site 710696010292 glycine-pyridoxal phosphate binding site [chemical binding]; other site 710696010293 folate binding site [chemical binding]; other site 710696010294 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 710696010295 lipoyl attachment site [posttranslational modification]; other site 710696010296 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 710696010297 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 710696010298 glycine dehydrogenase; Provisional; Region: PRK05367 710696010299 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 710696010300 tetramer interface [polypeptide binding]; other site 710696010301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696010302 catalytic residue [active] 710696010303 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 710696010304 tetramer interface [polypeptide binding]; other site 710696010305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696010306 catalytic residue [active] 710696010307 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 710696010308 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 710696010309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710696010310 Walker A/P-loop; other site 710696010311 ATP binding site [chemical binding]; other site 710696010312 Q-loop/lid; other site 710696010313 ABC transporter signature motif; other site 710696010314 Walker B; other site 710696010315 D-loop; other site 710696010316 H-loop/switch region; other site 710696010317 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710696010318 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710696010319 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 710696010320 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710696010321 DNA binding residues [nucleotide binding] 710696010322 dimer interface [polypeptide binding]; other site 710696010323 Protein of unknown function (DUF664); Region: DUF664; pfam04978 710696010324 DinB superfamily; Region: DinB_2; pfam12867 710696010325 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 710696010326 Phosphotransferase enzyme family; Region: APH; pfam01636 710696010327 active site 710696010328 ATP binding site [chemical binding]; other site 710696010329 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 710696010330 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710696010331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710696010332 homodimer interface [polypeptide binding]; other site 710696010333 catalytic residue [active] 710696010334 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 710696010335 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 710696010336 Walker A motif; other site 710696010337 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 710696010338 replicative DNA helicase; Region: DnaB; TIGR00665 710696010339 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 710696010340 ATP binding site [chemical binding]; other site 710696010341 Walker B motif; other site 710696010342 DNA binding loops [nucleotide binding] 710696010343 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 710696010344 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 710696010345 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 710696010346 putative active site [active] 710696010347 putative metal binding site [ion binding]; other site 710696010348 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 710696010349 active site 710696010350 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 710696010351 A new structural DNA glycosylase; Region: AlkD_like; cl11434 710696010352 active site 710696010353 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 710696010354 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 710696010355 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 710696010356 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 710696010357 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 710696010358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696010359 ABC-ATPase subunit interface; other site 710696010360 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710696010361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710696010362 dimer interface [polypeptide binding]; other site 710696010363 conserved gate region; other site 710696010364 putative PBP binding loops; other site 710696010365 ABC-ATPase subunit interface; other site 710696010366 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 710696010367 beta-galactosidase; Region: BGL; TIGR03356 710696010368 Transcriptional regulators [Transcription]; Region: PurR; COG1609 710696010369 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 710696010370 DNA binding site [nucleotide binding] 710696010371 domain linker motif; other site 710696010372 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 710696010373 putative dimerization interface [polypeptide binding]; other site 710696010374 putative ligand binding site [chemical binding]; other site 710696010375 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 710696010376 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 710696010377 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 710696010378 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 710696010379 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 710696010380 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 710696010381 dimer interface [polypeptide binding]; other site 710696010382 ssDNA binding site [nucleotide binding]; other site 710696010383 tetramer (dimer of dimers) interface [polypeptide binding]; other site 710696010384 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 710696010385 Transglycosylase; Region: Transgly; pfam00912 710696010386 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 710696010387 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 710696010388 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 710696010389 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696010390 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710696010391 DNA binding residues [nucleotide binding] 710696010392 Predicted transcriptional regulators [Transcription]; Region: COG1695 710696010393 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 710696010394 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 710696010395 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 710696010396 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 710696010397 active site 710696010398 catalytic residues [active] 710696010399 CHAT domain; Region: CHAT; pfam12770 710696010400 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710696010401 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696010402 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 710696010403 Septum formation; Region: Septum_form; pfam13845 710696010404 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 710696010405 active site 710696010406 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 710696010407 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 710696010408 active site 710696010409 NTP binding site [chemical binding]; other site 710696010410 metal binding triad [ion binding]; metal-binding site 710696010411 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 710696010412 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710696010413 Zn2+ binding site [ion binding]; other site 710696010414 Mg2+ binding site [ion binding]; other site 710696010415 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 710696010416 active site 710696010417 Ap6A binding site [chemical binding]; other site 710696010418 nudix motif; other site 710696010419 metal binding site [ion binding]; metal-binding site 710696010420 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 710696010421 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710696010422 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710696010423 DNA binding residues [nucleotide binding] 710696010424 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 710696010425 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710696010426 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710696010427 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710696010428 catalytic residues [active] 710696010429 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 710696010430 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 710696010431 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 710696010432 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 710696010433 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 710696010434 active site 710696010435 metal binding site [ion binding]; metal-binding site 710696010436 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710696010437 Coenzyme A binding pocket [chemical binding]; other site 710696010438 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 710696010439 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 710696010440 active site 710696010441 metal binding site [ion binding]; metal-binding site 710696010442 hexamer interface [polypeptide binding]; other site 710696010443 Domain of unknown function (DUF385); Region: DUF385; cl04387 710696010444 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 710696010445 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 710696010446 DNA binding site [nucleotide binding] 710696010447 catalytic residue [active] 710696010448 putative catalytic residues [active] 710696010449 H2TH interface [polypeptide binding]; other site 710696010450 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710696010451 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710696010452 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 710696010453 ParB-like nuclease domain; Region: ParBc; pfam02195 710696010454 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710696010455 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710696010456 Magnesium ion binding site [ion binding]; other site 710696010457 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 710696010458 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 710696010459 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 710696010460 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 710696010461 G-X-X-G motif; other site 710696010462 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 710696010463 RxxxH motif; other site 710696010464 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 710696010465 Haemolytic domain; Region: Haemolytic; pfam01809 710696010466 Ribonuclease P; Region: Ribonuclease_P; pfam00825 710696010467 Ribosomal protein L34; Region: Ribosomal_L34; cl00370