-- dump date 20111121_012448 -- class Genbank::misc_feature -- table misc_feature_note -- id note 656519000001 hypothetical protein; Validated; Region: PRK06672 656519000002 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 656519000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519000004 Walker A motif; other site 656519000005 ATP binding site [chemical binding]; other site 656519000006 Walker B motif; other site 656519000007 arginine finger; other site 656519000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 656519000009 DnaA box-binding interface [nucleotide binding]; other site 656519000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 656519000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 656519000012 putative DNA binding surface [nucleotide binding]; other site 656519000013 dimer interface [polypeptide binding]; other site 656519000014 beta-clamp/clamp loader binding surface; other site 656519000015 beta-clamp/translesion DNA polymerase binding surface; other site 656519000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 656519000017 recombination protein F; Reviewed; Region: recF; PRK00064 656519000018 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 656519000019 Walker A/P-loop; other site 656519000020 ATP binding site [chemical binding]; other site 656519000021 Q-loop/lid; other site 656519000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519000023 ABC transporter signature motif; other site 656519000024 Walker B; other site 656519000025 D-loop; other site 656519000026 H-loop/switch region; other site 656519000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 656519000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656519000029 ATP binding site [chemical binding]; other site 656519000030 Mg2+ binding site [ion binding]; other site 656519000031 G-X-G motif; other site 656519000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 656519000033 anchoring element; other site 656519000034 dimer interface [polypeptide binding]; other site 656519000035 ATP binding site [chemical binding]; other site 656519000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 656519000037 active site 656519000038 putative metal-binding site [ion binding]; other site 656519000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 656519000040 DNA gyrase subunit A; Validated; Region: PRK05560 656519000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 656519000042 CAP-like domain; other site 656519000043 Active site [active] 656519000044 primary dimer interface [polypeptide binding]; other site 656519000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 656519000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 656519000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 656519000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 656519000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 656519000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 656519000051 glycerol kinase; Provisional; Region: glpK; PRK00047 656519000052 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 656519000053 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 656519000054 Predicted dehydrogenase [General function prediction only]; Region: COG0579 656519000055 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 656519000056 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 656519000057 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 656519000058 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519000059 Protein of unknown function (DUF1667); Region: DUF1667; cl01591 656519000060 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 656519000061 conserved cys residue [active] 656519000062 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 656519000063 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 656519000064 DAK2 domain; Region: Dak2; cl03685 656519000065 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 656519000066 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 656519000067 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656519000068 DNA-binding site [nucleotide binding]; DNA binding site 656519000069 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 656519000070 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 656519000071 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 656519000072 putative substrate binding site [chemical binding]; other site 656519000073 putative ATP binding site [chemical binding]; other site 656519000074 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 656519000075 active site 656519000076 phosphorylation site [posttranslational modification] 656519000077 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 656519000078 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 656519000079 P-loop; other site 656519000080 active site 656519000081 phosphorylation site [posttranslational modification] 656519000082 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 656519000083 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 656519000084 SurA N-terminal domain; Region: SurA_N; pfam09312 656519000085 PPIC-type PPIASE domain; Region: Rotamase; cl08278 656519000086 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 656519000087 Uncharacterized conserved protein [Function unknown]; Region: COG3875 656519000088 seryl-tRNA synthetase; Provisional; Region: PRK05431 656519000089 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 656519000090 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 656519000091 dimer interface [polypeptide binding]; other site 656519000092 active site 656519000093 motif 1; other site 656519000094 motif 2; other site 656519000095 motif 3; other site 656519000096 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 656519000097 active site 656519000098 intersubunit interface [polypeptide binding]; other site 656519000099 catalytic residue [active] 656519000100 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 656519000101 substrate binding site [chemical binding]; other site 656519000102 ATP binding site [chemical binding]; other site 656519000103 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 656519000104 substrate binding site [chemical binding]; other site 656519000105 ATP binding site [chemical binding]; other site 656519000106 ATP cone domain; Region: ATP-cone; pfam03477 656519000107 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 656519000108 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 656519000109 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 656519000110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519000111 Phage integrase family; Region: Phage_integrase; pfam00589 656519000112 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 656519000113 Int/Topo IB signature motif; other site 656519000114 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 656519000115 ParB-like nuclease domain; Region: ParBc; cl02129 656519000116 ParB-like partition proteins; Region: parB_part; TIGR00180 656519000117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519000118 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 656519000119 DNA binding site [nucleotide binding] 656519000120 Int/Topo IB signature motif; other site 656519000121 active site 656519000122 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 656519000123 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 656519000124 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519000125 Walker A/P-loop; other site 656519000126 ATP binding site [chemical binding]; other site 656519000127 Q-loop/lid; other site 656519000128 ABC transporter signature motif; other site 656519000129 Walker B; other site 656519000130 D-loop; other site 656519000131 H-loop/switch region; other site 656519000132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 656519000133 active site 656519000134 nucleotide binding site [chemical binding]; other site 656519000135 HIGH motif; other site 656519000136 KMSKS motif; other site 656519000137 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 656519000138 tetramer interface [polypeptide binding]; other site 656519000139 active site 656519000140 Mg2+/Mn2+ binding site [ion binding]; other site 656519000141 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 656519000142 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 656519000143 PYR/PP interface [polypeptide binding]; other site 656519000144 dimer interface [polypeptide binding]; other site 656519000145 TPP binding site [chemical binding]; other site 656519000146 TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as bialaphos tripeptide in Streptomyces hygroscopicus...; Region: TPP_PpyrDC; cd03371 656519000147 TPP-binding site; other site 656519000148 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 656519000149 active site 656519000150 Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182 656519000151 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 656519000152 putative active site [active] 656519000153 metal binding site [ion binding]; metal-binding site 656519000154 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519000155 putative transposase OrfB; Reviewed; Region: PHA02517 656519000156 Integrase core domain; Region: rve; cl01316 656519000157 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 656519000158 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 656519000159 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 656519000160 putative ADP-binding pocket [chemical binding]; other site 656519000161 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519000162 putative transposase OrfB; Reviewed; Region: PHA02517 656519000163 Integrase core domain; Region: rve; cl01316 656519000164 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 656519000165 Integrase core domain; Region: rve; cl01316 656519000166 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519000167 putative transposase OrfB; Reviewed; Region: PHA02517 656519000168 Integrase core domain; Region: rve; cl01316 656519000169 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 656519000170 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 656519000171 putative ADP-binding pocket [chemical binding]; other site 656519000172 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 656519000173 active site 656519000174 ATP binding site [chemical binding]; other site 656519000175 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 656519000176 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 656519000177 putative ADP-binding pocket [chemical binding]; other site 656519000178 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 656519000179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519000180 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 656519000181 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 656519000182 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 656519000183 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 656519000184 putative NAD(P) binding site [chemical binding]; other site 656519000185 active site 656519000186 putative substrate binding site [chemical binding]; other site 656519000187 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 656519000188 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 656519000189 putative ADP-binding pocket [chemical binding]; other site 656519000190 Bacterial sugar transferase; Region: Bac_transf; cl00939 656519000191 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 656519000192 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 656519000193 inhibitor-cofactor binding pocket; inhibition site 656519000194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519000195 catalytic residue [active] 656519000196 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 656519000197 Phage integrase family; Region: Phage_integrase; pfam00589 656519000198 DNA binding site [nucleotide binding] 656519000199 Int/Topo IB signature motif; other site 656519000200 active site 656519000201 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656519000202 non-specific DNA binding site [nucleotide binding]; other site 656519000203 salt bridge; other site 656519000204 sequence-specific DNA binding site [nucleotide binding]; other site 656519000205 DNA primase, catalytic core; Region: dnaG; TIGR01391 656519000206 DNA primase, catalytic core; Region: dnaG; TIGR01391 656519000207 CHC2 zinc finger; Region: zf-CHC2; cl02597 656519000208 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 656519000209 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication...; Region: TOPRIM_primases; cd01029 656519000210 active site 656519000211 metal binding site [ion binding]; metal-binding site 656519000212 interdomain interaction site; other site 656519000213 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 656519000214 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 656519000215 G2 box; other site 656519000216 Switch I region; other site 656519000217 G3 box; other site 656519000218 Switch II region; other site 656519000219 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 656519000220 RecT family; Region: RecT; cl04285 656519000221 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 656519000222 MPN+ (JAMM) motif; other site 656519000223 Zinc-binding site [ion binding]; other site 656519000224 Transposase, Mutator family; Region: Transposase_mut; pfam00872 656519000225 MULE transposase domain; Region: MULE; pfam10551 656519000226 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 656519000227 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 656519000228 FeS/SAM binding site; other site 656519000229 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 656519000230 hypothetical protein; Provisional; Region: PRK10396 656519000231 SEC-C motif; Region: SEC-C; cl12132 656519000232 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 656519000233 Sulfate transporter family; Region: Sulfate_transp; cl00967 656519000234 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 656519000235 Transposase domain (DUF772); Region: DUF772; cl12084 656519000236 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 656519000237 Sulfatase; Region: Sulfatase; cl10460 656519000238 Sodium:solute symporter family; Region: SSF; cl00456 656519000239 putative transporter; Provisional; Region: PRK10484 656519000240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519000241 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 656519000242 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 656519000243 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 656519000244 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 656519000245 active site 656519000246 catalytic tetrad [active] 656519000247 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 656519000248 Protein of unknown function (DUF328); Region: DUF328; cl01143 656519000249 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 656519000250 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 656519000251 putative active site [active] 656519000252 catalytic site [active] 656519000253 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 656519000254 putative active site [active] 656519000255 catalytic site [active] 656519000256 Transposase, Mutator family; Region: Transposase_mut; pfam00872 656519000257 MULE transposase domain; Region: MULE; pfam10551 656519000258 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 656519000259 Transposase domain (DUF772); Region: DUF772; cl12084 656519000260 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 656519000261 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846 656519000262 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 656519000263 ATP binding site [chemical binding]; other site 656519000264 active site 656519000265 substrate binding site [chemical binding]; other site 656519000266 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 656519000267 HSP70 interaction site [polypeptide binding]; other site 656519000268 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 656519000269 MatE; Region: MatE; pfam01554 656519000270 MatE; Region: MatE; pfam01554 656519000271 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 656519000272 catalytic motif [active] 656519000273 Zn binding site [ion binding]; other site 656519000274 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 656519000275 homodimer interaction site [polypeptide binding]; other site 656519000276 cofactor binding site; other site 656519000277 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 656519000278 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 656519000279 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 656519000280 Putative esterase; Region: Esterase; pfam00756 656519000281 Putative esterase; Region: Esterase; pfam00756 656519000282 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 656519000283 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 656519000284 fructokinase; Reviewed; Region: PRK09557 656519000285 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 656519000286 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 656519000287 NAD binding site [chemical binding]; other site 656519000288 homodimer interface [polypeptide binding]; other site 656519000289 active site 656519000290 substrate binding site [chemical binding]; other site 656519000291 galactokinase; Provisional; Region: PRK05322 656519000292 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 656519000293 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 656519000294 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 656519000295 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 656519000296 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 656519000297 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 656519000298 Predicted transcriptional regulator [Transcription]; Region: COG4189 656519000299 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656519000300 dimerization interface [polypeptide binding]; other site 656519000301 putative DNA binding site [nucleotide binding]; other site 656519000302 putative Zn2+ binding site [ion binding]; other site 656519000303 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 656519000304 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656519000305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519000306 dimer interface [polypeptide binding]; other site 656519000307 conserved gate region; other site 656519000308 putative PBP binding loops; other site 656519000309 ABC-ATPase subunit interface; other site 656519000310 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 656519000311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519000312 dimer interface [polypeptide binding]; other site 656519000313 conserved gate region; other site 656519000314 putative PBP binding loops; other site 656519000315 ABC-ATPase subunit interface; other site 656519000316 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 656519000317 domain; Region: Glyco_hydro_2; pfam00703 656519000318 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 656519000319 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 656519000320 PAS domain S-box; Region: sensory_box; TIGR00229 656519000321 PAS domain S-box; Region: sensory_box; TIGR00229 656519000322 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519000323 putative active site [active] 656519000324 heme pocket [chemical binding]; other site 656519000325 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519000326 metal binding site [ion binding]; metal-binding site 656519000327 active site 656519000328 I-site; other site 656519000329 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519000330 Zn2+ binding site [ion binding]; other site 656519000331 Mg2+ binding site [ion binding]; other site 656519000332 Fasciclin domain; Region: Fasciclin; cl02663 656519000333 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 656519000334 active site 656519000335 intersubunit interactions; other site 656519000336 catalytic residue [active] 656519000337 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cd00449 656519000338 homodimer interface [polypeptide binding]; other site 656519000339 substrate-cofactor binding pocket; other site 656519000340 Aminotransferase class IV; Region: Aminotran_4; pfam01063 656519000341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519000342 catalytic residue [active] 656519000343 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 656519000344 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 656519000345 chorismate binding enzyme; Region: Chorismate_bind; cl10555 656519000346 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 656519000347 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 656519000348 glutamine binding [chemical binding]; other site 656519000349 catalytic triad [active] 656519000350 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519000351 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 656519000352 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 656519000353 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 656519000354 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519000355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519000356 PRD domain; Region: PRD; pfam00874 656519000357 PRD domain; Region: PRD; pfam00874 656519000358 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 656519000359 P-loop; other site 656519000360 active site 656519000361 phosphorylation site [posttranslational modification] 656519000362 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 656519000363 active site 656519000364 phosphorylation site [posttranslational modification] 656519000365 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 656519000366 active site 656519000367 phosphorylation site [posttranslational modification] 656519000368 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 656519000369 P-loop; other site 656519000370 active site 656519000371 phosphorylation site [posttranslational modification] 656519000372 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 656519000373 Nitrogen regulatory protein P-II; Region: P-II; cl00412 656519000374 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 656519000375 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519000376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519000377 Walker A motif; other site 656519000378 ATP binding site [chemical binding]; other site 656519000379 Walker B motif; other site 656519000380 arginine finger; other site 656519000381 Transcriptional antiterminator [Transcription]; Region: COG3933 656519000382 PRD domain; Region: PRD; pfam00874 656519000383 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 656519000384 active pocket/dimerization site; other site 656519000385 active site 656519000386 phosphorylation site [posttranslational modification] 656519000387 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 656519000388 dimerization domain swap beta strand [polypeptide binding]; other site 656519000389 regulatory protein interface [polypeptide binding]; other site 656519000390 active site 656519000391 regulatory phosphorylation site [posttranslational modification]; other site 656519000392 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 656519000393 active site 656519000394 P-loop; other site 656519000395 phosphorylation site [posttranslational modification] 656519000396 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 656519000397 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 656519000398 methionine cluster; other site 656519000399 active site 656519000400 phosphorylation site [posttranslational modification] 656519000401 metal binding site [ion binding]; metal-binding site 656519000402 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 656519000403 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 656519000404 NAD binding site [chemical binding]; other site 656519000405 sugar binding site [chemical binding]; other site 656519000406 divalent metal binding site [ion binding]; other site 656519000407 tetramer (dimer of dimers) interface [polypeptide binding]; other site 656519000408 dimer interface [polypeptide binding]; other site 656519000409 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 656519000410 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 656519000411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 656519000412 active site 656519000413 motif I; other site 656519000414 motif II; other site 656519000415 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 656519000416 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 656519000417 ligand binding site [chemical binding]; other site 656519000418 CAT RNA binding domain; Region: CAT_RBD; pfam03123 656519000419 transcriptional antiterminator BglG; Provisional; Region: PRK09772 656519000420 PRD domain; Region: PRD; pfam00874 656519000421 PRD domain; Region: PRD; pfam00874 656519000422 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 656519000423 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 656519000424 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 656519000425 active site turn [active] 656519000426 phosphorylation site [posttranslational modification] 656519000427 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 656519000428 HPr interaction site; other site 656519000429 glycerol kinase (GK) interaction site [polypeptide binding]; other site 656519000430 active site 656519000431 phosphorylation site [posttranslational modification] 656519000432 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 656519000433 active site 656519000434 trimer interface [polypeptide binding]; other site 656519000435 allosteric site; other site 656519000436 active site lid [active] 656519000437 hexamer (dimer of trimers) interface [polypeptide binding]; other site 656519000438 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 656519000439 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 656519000440 active site 656519000441 dimer interface [polypeptide binding]; other site 656519000442 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as...; Region: OYE_like_FMN_family; cd02803 656519000443 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 656519000444 active site 656519000445 FMN binding site [chemical binding]; other site 656519000446 substrate binding site [chemical binding]; other site 656519000447 putative catalytic residue [active] 656519000448 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519000449 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519000450 Integrase core domain; Region: rve; cl01316 656519000451 Cupin domain; Region: Cupin_2; cl09118 656519000452 Membrane transport protein; Region: Mem_trans; cl09117 656519000453 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 656519000454 dimerization domain swap beta strand [polypeptide binding]; other site 656519000455 regulatory protein interface [polypeptide binding]; other site 656519000456 active site 656519000457 regulatory phosphorylation site [posttranslational modification]; other site 656519000458 Transcriptional regulators [Transcription]; Region: GntR; COG1802 656519000459 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656519000460 DNA-binding site [nucleotide binding]; DNA binding site 656519000461 FCD domain; Region: FCD; cl11656 656519000462 Transcriptional regulators [Transcription]; Region: GntR; COG1802 656519000463 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656519000464 DNA-binding site [nucleotide binding]; DNA binding site 656519000465 FCD domain; Region: FCD; cl11656 656519000466 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 656519000467 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519000468 Walker A/P-loop; other site 656519000469 ATP binding site [chemical binding]; other site 656519000470 Q-loop/lid; other site 656519000471 ABC transporter signature motif; other site 656519000472 Walker B; other site 656519000473 D-loop; other site 656519000474 H-loop/switch region; other site 656519000475 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 656519000476 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 656519000477 TM-ABC transporter signature motif; other site 656519000478 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 656519000479 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 656519000480 ligand binding site [chemical binding]; other site 656519000481 dimerization interface [polypeptide binding]; other site 656519000482 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 656519000483 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 656519000484 tetramer interface [polypeptide binding]; other site 656519000485 TPP-binding site [chemical binding]; other site 656519000486 heterodimer interface [polypeptide binding]; other site 656519000487 phosphorylation loop region [posttranslational modification] 656519000488 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 656519000489 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 656519000490 alpha subunit interface [polypeptide binding]; other site 656519000491 TPP binding site [chemical binding]; other site 656519000492 heterodimer interface [polypeptide binding]; other site 656519000493 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 656519000494 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 656519000495 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 656519000496 E3 interaction surface; other site 656519000497 lipoyl attachment site [posttranslational modification]; other site 656519000498 e3 binding domain; Region: E3_binding; pfam02817 656519000499 e3 binding domain; Region: E3_binding; pfam02817 656519000500 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 656519000501 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 656519000502 TM-ABC transporter signature motif; other site 656519000503 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 656519000504 TM-ABC transporter signature motif; other site 656519000505 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 656519000506 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_8; cd06317 656519000507 putative ligand binding site [chemical binding]; other site 656519000508 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 656519000509 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 656519000510 Walker A/P-loop; other site 656519000511 ATP binding site [chemical binding]; other site 656519000512 Q-loop/lid; other site 656519000513 ABC transporter signature motif; other site 656519000514 Walker B; other site 656519000515 D-loop; other site 656519000516 H-loop/switch region; other site 656519000517 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 656519000518 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 656519000519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519000520 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 656519000521 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 656519000522 Metal-binding active site; metal-binding site 656519000523 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 656519000524 classical (c) SDRs; Region: SDR_c; cd05233 656519000525 NAD(P) binding site [chemical binding]; other site 656519000526 active site 656519000527 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 656519000528 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cd01066 656519000529 active site 656519000530 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 656519000531 putative catalytic cysteine [active] 656519000532 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 656519000533 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 656519000534 CoA-ligase; Region: Ligase_CoA; pfam00549 656519000535 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 656519000536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519000537 CoA-ligase; Region: Ligase_CoA; pfam00549 656519000538 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 656519000539 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519000540 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 656519000541 Malic enzyme, N-terminal domain; Region: malic; pfam00390 656519000542 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 656519000543 putative NAD(P) binding site [chemical binding]; other site 656519000544 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 656519000545 Malic enzyme, N-terminal domain; Region: malic; pfam00390 656519000546 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 656519000547 putative NAD(P) binding site [chemical binding]; other site 656519000548 Uncharacterized conserved protein [Function unknown]; Region: COG3875 656519000549 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 656519000550 pyruvate phosphate dikinase; Provisional; Region: PRK09279 656519000551 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 656519000552 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 656519000553 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 656519000554 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 656519000555 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 656519000556 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 656519000557 Ligand Binding Site [chemical binding]; other site 656519000558 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 656519000559 dimer interface [polypeptide binding]; other site 656519000560 substrate binding site [chemical binding]; other site 656519000561 metal binding sites [ion binding]; metal-binding site 656519000562 Protein of unknown function (DUF964); Region: DUF964; cl01483 656519000563 PAS fold; Region: PAS_4; pfam08448 656519000564 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519000565 putative active site [active] 656519000566 heme pocket [chemical binding]; other site 656519000567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 656519000568 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 656519000569 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519000570 putative active site [active] 656519000571 heme pocket [chemical binding]; other site 656519000572 PAS domain S-box; Region: sensory_box; TIGR00229 656519000573 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519000574 putative active site [active] 656519000575 heme pocket [chemical binding]; other site 656519000576 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519000577 metal binding site [ion binding]; metal-binding site 656519000578 active site 656519000579 I-site; other site 656519000580 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519000581 Zn2+ binding site [ion binding]; other site 656519000582 Mg2+ binding site [ion binding]; other site 656519000583 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 656519000584 dimerization domain swap beta strand [polypeptide binding]; other site 656519000585 regulatory protein interface [polypeptide binding]; other site 656519000586 active site 656519000587 regulatory phosphorylation site [posttranslational modification]; other site 656519000588 GAF domain; Region: GAF; cl00853 656519000589 PAS fold; Region: PAS; pfam00989 656519000590 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519000591 putative active site [active] 656519000592 heme pocket [chemical binding]; other site 656519000593 PAS domain S-box; Region: sensory_box; TIGR00229 656519000594 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 656519000595 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519000596 metal binding site [ion binding]; metal-binding site 656519000597 active site 656519000598 I-site; other site 656519000599 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519000600 Zn2+ binding site [ion binding]; other site 656519000601 Mg2+ binding site [ion binding]; other site 656519000602 Late competence development protein ComFB; Region: ComFB; pfam10719 656519000603 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519000604 PAS fold; Region: PAS_3; pfam08447 656519000605 putative active site [active] 656519000606 heme pocket [chemical binding]; other site 656519000607 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519000608 PAS fold; Region: PAS_3; pfam08447 656519000609 putative active site [active] 656519000610 heme pocket [chemical binding]; other site 656519000611 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519000612 metal binding site [ion binding]; metal-binding site 656519000613 active site 656519000614 I-site; other site 656519000615 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519000616 Zn2+ binding site [ion binding]; other site 656519000617 Mg2+ binding site [ion binding]; other site 656519000618 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 656519000619 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 656519000620 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 656519000621 PAS domain S-box; Region: sensory_box; TIGR00229 656519000622 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519000623 PAS fold; Region: PAS_3; pfam08447 656519000624 putative active site [active] 656519000625 heme pocket [chemical binding]; other site 656519000626 PAS domain S-box; Region: sensory_box; TIGR00229 656519000627 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519000628 putative active site [active] 656519000629 heme pocket [chemical binding]; other site 656519000630 PAS domain S-box; Region: sensory_box; TIGR00229 656519000631 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 656519000632 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 656519000633 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 656519000634 dimer interface [polypeptide binding]; other site 656519000635 phosphorylation site [posttranslational modification] 656519000636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656519000637 ATP binding site [chemical binding]; other site 656519000638 Mg2+ binding site [ion binding]; other site 656519000639 G-X-G motif; other site 656519000640 Response regulator receiver domain; Region: Response_reg; pfam00072 656519000641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 656519000642 active site 656519000643 phosphorylation site [posttranslational modification] 656519000644 intermolecular recognition site; other site 656519000645 dimerization interface [polypeptide binding]; other site 656519000646 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 656519000647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 656519000648 S-adenosylmethionine binding site [chemical binding]; other site 656519000649 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 656519000650 B12 binding site [chemical binding]; other site 656519000651 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519000652 metal binding site [ion binding]; metal-binding site 656519000653 active site 656519000654 I-site; other site 656519000655 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 656519000656 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 656519000657 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 656519000658 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 656519000659 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 656519000660 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 656519000661 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 656519000662 IMP binding site; other site 656519000663 dimer interface [polypeptide binding]; other site 656519000664 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 656519000665 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519000666 putative active site [active] 656519000667 heme pocket [chemical binding]; other site 656519000668 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 656519000669 PAS fold; Region: PAS_3; pfam08447 656519000670 PAS domain S-box; Region: sensory_box; TIGR00229 656519000671 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519000672 putative active site [active] 656519000673 heme pocket [chemical binding]; other site 656519000674 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519000675 metal binding site [ion binding]; metal-binding site 656519000676 active site 656519000677 I-site; other site 656519000678 PAS domain S-box; Region: sensory_box; TIGR00229 656519000679 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519000680 putative active site [active] 656519000681 heme pocket [chemical binding]; other site 656519000682 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519000683 metal binding site [ion binding]; metal-binding site 656519000684 active site 656519000685 I-site; other site 656519000686 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519000687 Zn2+ binding site [ion binding]; other site 656519000688 Mg2+ binding site [ion binding]; other site 656519000689 Uncharacterized conserved protein [Function unknown]; Region: COG4997 656519000690 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 656519000691 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 656519000692 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 656519000693 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 656519000694 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 656519000695 active site 656519000696 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 656519000697 domain_subunit interface; other site 656519000698 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 656519000699 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 656519000700 active site 656519000701 FMN binding site [chemical binding]; other site 656519000702 substrate binding site [chemical binding]; other site 656519000703 3Fe-4S cluster binding site [ion binding]; other site 656519000704 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 656519000705 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 656519000706 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 656519000707 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 656519000708 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 656519000709 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 656519000710 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 656519000711 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 656519000712 homotrimer interaction site [polypeptide binding]; other site 656519000713 putative active site [active] 656519000714 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 656519000715 putative active site [active] 656519000716 catalytic site [active] 656519000717 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 656519000718 ATP binding site [chemical binding]; other site 656519000719 putative Mg++ binding site [ion binding]; other site 656519000720 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 656519000721 Superfamily II helicase, archaea-specific [General function prediction only]; Region: COG1202 656519000722 nucleotide binding region [chemical binding]; other site 656519000723 ATP-binding site [chemical binding]; other site 656519000724 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 656519000725 nucleotide binding site/active site [active] 656519000726 HIT family signature motif; other site 656519000727 catalytic residue [active] 656519000728 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 656519000729 DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238 656519000730 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519000731 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519000732 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 656519000733 putative transposase OrfB; Reviewed; Region: PHA02517 656519000734 Integrase core domain; Region: rve; cl01316 656519000735 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 656519000736 Domain of unknown function DUF87; Region: DUF87; pfam01935 656519000737 AAA-like domain; Region: AAA_10; pfam12846 656519000738 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 656519000739 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 656519000740 minor groove reading motif; other site 656519000741 helix-hairpin-helix signature motif; other site 656519000742 substrate binding pocket [chemical binding]; other site 656519000743 active site 656519000744 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 656519000745 putative active site [active] 656519000746 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 656519000747 putative active site [active] 656519000748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 656519000749 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 656519000750 cofactor binding site; other site 656519000751 DNA binding site [nucleotide binding] 656519000752 substrate interaction site [chemical binding]; other site 656519000753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 656519000754 Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417 656519000755 YvrJ protein family; Region: YvrJ; pfam12841 656519000756 transposase; Provisional; Region: PRK06526 656519000757 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519000758 Walker A motif; other site 656519000759 ATP binding site [chemical binding]; other site 656519000760 Walker B motif; other site 656519000761 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519000762 Integrase core domain; Region: rve; cl01316 656519000763 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 656519000764 hypothetical protein; Provisional; Region: PRK05590 656519000765 SEC-C motif; Region: SEC-C; cl12132 656519000766 GAF domain; Region: GAF; cl00853 656519000767 PAS domain S-box; Region: sensory_box; TIGR00229 656519000768 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 656519000769 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519000770 PAS fold; Region: PAS_3; pfam08447 656519000771 putative active site [active] 656519000772 heme pocket [chemical binding]; other site 656519000773 GAF domain; Region: GAF; cl00853 656519000774 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519000775 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 656519000776 metal binding site [ion binding]; metal-binding site 656519000777 active site 656519000778 I-site; other site 656519000779 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519000780 Zn2+ binding site [ion binding]; other site 656519000781 Mg2+ binding site [ion binding]; other site 656519000782 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 656519000783 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 656519000784 dimer interface [polypeptide binding]; other site 656519000785 active site 656519000786 metal binding site [ion binding]; metal-binding site 656519000787 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 656519000788 intersubunit interface [polypeptide binding]; other site 656519000789 active site 656519000790 catalytic residue [active] 656519000791 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 656519000792 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 656519000793 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 656519000794 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 656519000795 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 656519000796 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 656519000797 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 656519000798 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 656519000799 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 656519000800 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 656519000801 Walker A/P-loop; other site 656519000802 ATP binding site [chemical binding]; other site 656519000803 Q-loop/lid; other site 656519000804 ABC transporter signature motif; other site 656519000805 Walker B; other site 656519000806 D-loop; other site 656519000807 H-loop/switch region; other site 656519000808 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 656519000809 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 656519000810 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519000811 Walker A/P-loop; other site 656519000812 ATP binding site [chemical binding]; other site 656519000813 Q-loop/lid; other site 656519000814 ABC transporter signature motif; other site 656519000815 Walker B; other site 656519000816 D-loop; other site 656519000817 H-loop/switch region; other site 656519000818 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656519000819 dimerization interface [polypeptide binding]; other site 656519000820 putative DNA binding site [nucleotide binding]; other site 656519000821 putative Zn2+ binding site [ion binding]; other site 656519000822 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 656519000823 Integrase core domain; Region: rve; cl01316 656519000824 Domain of unknown function DUF11; Region: DUF11; cl03172 656519000825 Domain of unknown function DUF11; Region: DUF11; cl03172 656519000826 Domain of unknown function DUF11; Region: DUF11; cl03172 656519000827 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 656519000828 short chain dehydrogenase; Provisional; Region: PRK06197 656519000829 putative NAD(P) binding site [chemical binding]; other site 656519000830 active site 656519000831 PAS domain S-box; Region: sensory_box; TIGR00229 656519000832 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519000833 metal binding site [ion binding]; metal-binding site 656519000834 active site 656519000835 I-site; other site 656519000836 Probable transposase; Region: OrfB_IS605; pfam01385 656519000837 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 656519000838 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 656519000839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 656519000840 active site 656519000841 phosphorylation site [posttranslational modification] 656519000842 intermolecular recognition site; other site 656519000843 dimerization interface [polypeptide binding]; other site 656519000844 GAF domain; Region: GAF; cl00853 656519000845 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519000846 Zn2+ binding site [ion binding]; other site 656519000847 Mg2+ binding site [ion binding]; other site 656519000848 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; cl00804 656519000849 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 656519000850 catalytic core [active] 656519000851 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 656519000852 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 656519000853 homodimer interface [polypeptide binding]; other site 656519000854 substrate-cofactor binding pocket; other site 656519000855 catalytic residue [active] 656519000856 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 656519000857 Tetramer interface [polypeptide binding]; other site 656519000858 Active site [active] 656519000859 FMN-binding site [chemical binding]; other site 656519000860 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 656519000861 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 656519000862 putative NAD(P) binding site [chemical binding]; other site 656519000863 catalytic Zn binding site [ion binding]; other site 656519000864 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 656519000865 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 656519000866 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 656519000867 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 656519000868 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 656519000869 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 656519000870 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 656519000871 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 656519000872 putative recombination protein RecB; Provisional; Region: PRK13909 656519000873 UvrD/REP helicase; Region: UvrD-helicase; cl14126 656519000874 UvrD/REP helicase; Region: UvrD-helicase; cl14126 656519000875 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 656519000876 intersubunit interface [polypeptide binding]; other site 656519000877 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 656519000878 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 656519000879 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 656519000880 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 656519000881 ABC-ATPase subunit interface; other site 656519000882 dimer interface [polypeptide binding]; other site 656519000883 putative PBP binding regions; other site 656519000884 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 656519000885 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 656519000886 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519000887 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 656519000888 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 656519000889 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 656519000890 Domain of unknown function DUF77; Region: DUF77; cl00307 656519000891 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 656519000892 MatE; Region: MatE; pfam01554 656519000893 MatE; Region: MatE; pfam01554 656519000894 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656519000895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656519000896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656519000897 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656519000898 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 656519000899 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 656519000900 Walker A/P-loop; other site 656519000901 ATP binding site [chemical binding]; other site 656519000902 Q-loop/lid; other site 656519000903 ABC transporter signature motif; other site 656519000904 Walker B; other site 656519000905 D-loop; other site 656519000906 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 656519000907 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 656519000908 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 656519000909 FtsX-like permease family; Region: FtsX; pfam02687 656519000910 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 656519000911 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes...; Region: NADPH_oxidoreductase_1; cd02150 656519000912 putative FMN binding site [chemical binding]; other site 656519000913 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 656519000914 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 656519000915 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 656519000916 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 656519000917 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 656519000918 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 656519000919 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 656519000920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 656519000921 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 656519000922 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 656519000923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519000924 dimer interface [polypeptide binding]; other site 656519000925 conserved gate region; other site 656519000926 ABC-ATPase subunit interface; other site 656519000927 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 656519000928 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 656519000929 Walker A/P-loop; other site 656519000930 ATP binding site [chemical binding]; other site 656519000931 Q-loop/lid; other site 656519000932 ABC transporter signature motif; other site 656519000933 Walker B; other site 656519000934 D-loop; other site 656519000935 H-loop/switch region; other site 656519000936 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 656519000937 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 656519000938 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 656519000939 Walker A/P-loop; other site 656519000940 ATP binding site [chemical binding]; other site 656519000941 Q-loop/lid; other site 656519000942 ABC transporter signature motif; other site 656519000943 Walker B; other site 656519000944 D-loop; other site 656519000945 H-loop/switch region; other site 656519000946 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 656519000947 Predicted amidohydrolase [General function prediction only]; Region: COG0388 656519000948 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 656519000949 active site 656519000950 catalytic triad [active] 656519000951 dimer interface [polypeptide binding]; other site 656519000952 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 656519000953 nudix motif; other site 656519000954 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 656519000955 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 656519000956 active site 656519000957 ADP/pyrophosphate binding site [chemical binding]; other site 656519000958 dimerization interface [polypeptide binding]; other site 656519000959 allosteric effector site; other site 656519000960 fructose-1,6-bisphosphate binding site; other site 656519000961 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 656519000962 catalytic residue [active] 656519000963 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 656519000964 Thermostable 8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: COG1059 656519000965 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 656519000966 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 656519000967 putative NAD(P) binding site [chemical binding]; other site 656519000968 putative active site [active] 656519000969 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 656519000970 catalytic residue [active] 656519000971 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 656519000972 GAF domain; Region: GAF; cl00853 656519000973 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 656519000974 allantoate amidohydrolase; Reviewed; Region: PRK09290 656519000975 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 656519000976 active site 656519000977 metal binding site [ion binding]; metal-binding site 656519000978 dimer interface [polypeptide binding]; other site 656519000979 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 656519000980 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 656519000981 metal binding site [ion binding]; metal-binding site 656519000982 putative dimer interface [polypeptide binding]; other site 656519000983 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 656519000984 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 656519000985 metal binding site [ion binding]; metal-binding site 656519000986 putative dimer interface [polypeptide binding]; other site 656519000987 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 656519000988 active site 656519000989 DNA binding site [nucleotide binding] 656519000990 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 656519000991 active site 656519000992 catalytic residues [active] 656519000993 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 656519000994 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 656519000995 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 656519000996 Cupin domain; Region: Cupin_2; cl09118 656519000997 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 656519000998 PAS fold; Region: PAS_4; pfam08448 656519000999 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 656519001000 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519001001 putative active site [active] 656519001002 heme pocket [chemical binding]; other site 656519001003 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519001004 putative active site [active] 656519001005 heme pocket [chemical binding]; other site 656519001006 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519001007 PAS fold; Region: PAS_3; pfam08447 656519001008 putative active site [active] 656519001009 heme pocket [chemical binding]; other site 656519001010 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519001011 metal binding site [ion binding]; metal-binding site 656519001012 active site 656519001013 I-site; other site 656519001014 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519001015 Zn2+ binding site [ion binding]; other site 656519001016 Mg2+ binding site [ion binding]; other site 656519001017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519001018 PAS domain S-box; Region: sensory_box; TIGR00229 656519001019 putative diguanylate cyclase; Provisional; Region: PRK09776 656519001020 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519001021 metal binding site [ion binding]; metal-binding site 656519001022 active site 656519001023 I-site; other site 656519001024 Peptidase family M48; Region: Peptidase_M48; cl12018 656519001025 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 656519001026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519001027 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 656519001028 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 656519001029 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 656519001030 inhibitor-cofactor binding pocket; inhibition site 656519001031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519001032 catalytic residue [active] 656519001033 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142 656519001034 putative FMN binding site [chemical binding]; other site 656519001035 NADPH bind site [chemical binding]; other site 656519001036 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 656519001037 nucleoside/Zn binding site; other site 656519001038 dimer interface [polypeptide binding]; other site 656519001039 catalytic motif [active] 656519001040 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 656519001041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519001042 Walker A motif; other site 656519001043 ATP binding site [chemical binding]; other site 656519001044 Walker B motif; other site 656519001045 arginine finger; other site 656519001046 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 656519001047 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 656519001048 recombination protein RecR; Reviewed; Region: recR; PRK00076 656519001049 RecR protein; Region: RecR; pfam02132 656519001050 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 656519001051 putative active site [active] 656519001052 putative metal-binding site [ion binding]; other site 656519001053 tetramer interface [polypeptide binding]; other site 656519001054 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 656519001055 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 656519001056 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 656519001057 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 656519001058 active site 656519001059 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 656519001060 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519001061 thymidylate kinase; Validated; Region: tmk; PRK00698 656519001062 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 656519001063 TMP-binding site; other site 656519001064 ATP-binding site [chemical binding]; other site 656519001065 Nitrogen regulatory protein P-II; Region: P-II; cl00412 656519001066 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 656519001067 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519001068 DNA polymerase III subunit delta'; Validated; Region: PRK07940 656519001069 PSP1 C-terminal conserved region; Region: PSP1; cl00770 656519001070 Protein of unknown function (DUF972); Region: DUF972; cl01853 656519001071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 656519001072 S-adenosylmethionine binding site [chemical binding]; other site 656519001073 Predicted methyltransferases [General function prediction only]; Region: COG0313 656519001074 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 656519001075 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 656519001076 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 656519001077 active site 656519001078 HIGH motif; other site 656519001079 KMSKS motif; other site 656519001080 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 656519001081 tRNA binding surface [nucleotide binding]; other site 656519001082 anticodon binding site; other site 656519001083 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 656519001084 dimer interface [polypeptide binding]; other site 656519001085 putative tRNA-binding site [nucleotide binding]; other site 656519001086 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 656519001087 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 656519001088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519001089 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 656519001090 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 656519001091 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 656519001092 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 656519001093 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519001094 alanine racemase; Reviewed; Region: alr; PRK00053 656519001095 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 656519001096 active site 656519001097 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 656519001098 dimer interface [polypeptide binding]; other site 656519001099 substrate binding site [chemical binding]; other site 656519001100 catalytic residues [active] 656519001101 OsmC-like protein; Region: OsmC; cl00767 656519001102 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 656519001103 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519001104 3H domain; Region: 3H; pfam02829 656519001105 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 656519001106 Sodium:solute symporter family; Region: SSF; cl00456 656519001107 Quinolinate synthetase A protein; Region: NadA; cl00420 656519001108 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 656519001109 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519001110 domain; Region: Succ_DH_flav_C; pfam02910 656519001111 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 656519001112 nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078 656519001113 dimerization interface [polypeptide binding]; other site 656519001114 active site 656519001115 Quinolinate synthetase A protein; Region: NadA; cl00420 656519001116 PAS domain S-box; Region: sensory_box; TIGR00229 656519001117 PAS domain S-box; Region: sensory_box; TIGR00229 656519001118 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519001119 putative active site [active] 656519001120 heme pocket [chemical binding]; other site 656519001121 PAS fold; Region: PAS_3; pfam08447 656519001122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519001123 putative active site [active] 656519001124 PAS fold; Region: PAS_3; pfam08447 656519001125 heme pocket [chemical binding]; other site 656519001126 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 656519001127 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519001128 metal binding site [ion binding]; metal-binding site 656519001129 active site 656519001130 I-site; other site 656519001131 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519001132 Zn2+ binding site [ion binding]; other site 656519001133 Mg2+ binding site [ion binding]; other site 656519001134 prephenate dehydratase; Provisional; Region: PRK11898 656519001135 Prephenate dehydratase; Region: PDT; pfam00800 656519001136 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 656519001137 putative L-Phe binding site [chemical binding]; other site 656519001138 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 656519001139 NeuB family; Region: NeuB; cl00496 656519001140 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 656519001141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519001142 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 656519001143 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 656519001144 hinge; other site 656519001145 active site 656519001146 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 656519001147 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 656519001148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519001149 homodimer interface [polypeptide binding]; other site 656519001150 catalytic residue [active] 656519001151 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 656519001152 NeuB family; Region: NeuB; cl00496 656519001153 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 656519001154 Tetramer interface [polypeptide binding]; other site 656519001155 Active site [active] 656519001156 FMN-binding site [chemical binding]; other site 656519001157 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 656519001158 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 656519001159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 656519001160 active site 656519001161 phosphorylation site [posttranslational modification] 656519001162 intermolecular recognition site; other site 656519001163 dimerization interface [polypeptide binding]; other site 656519001164 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 656519001165 DNA binding site [nucleotide binding] 656519001166 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 656519001167 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 656519001168 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 656519001169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 656519001170 dimer interface [polypeptide binding]; other site 656519001171 phosphorylation site [posttranslational modification] 656519001172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656519001173 ATP binding site [chemical binding]; other site 656519001174 Mg2+ binding site [ion binding]; other site 656519001175 G-X-G motif; other site 656519001176 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 656519001177 oligomer interface [polypeptide binding]; other site 656519001178 putative active site [active] 656519001179 metal binding site [ion binding]; metal-binding site 656519001180 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 656519001181 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 656519001182 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 656519001183 catalytic residues [active] 656519001184 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 656519001185 catalytic residues [active] 656519001186 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 656519001187 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 656519001188 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 656519001189 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 656519001190 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 656519001191 active site 656519001192 HIGH motif; other site 656519001193 KMSK motif region; other site 656519001194 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 656519001195 tRNA binding surface [nucleotide binding]; other site 656519001196 anticodon binding site; other site 656519001197 CTP synthetase; Validated; Region: pyrG; PRK05380 656519001198 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 656519001199 Catalytic site [active] 656519001200 Active site [active] 656519001201 UTP binding site [chemical binding]; other site 656519001202 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 656519001203 active site 656519001204 putative oxyanion hole; other site 656519001205 catalytic triad [active] 656519001206 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 656519001207 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 656519001208 substrate binding site [chemical binding]; other site 656519001209 oxyanion hole (OAH) forming residues; other site 656519001210 trimer interface [polypeptide binding]; other site 656519001211 hypothetical protein; Provisional; Region: PRK08185 656519001212 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 656519001213 intersubunit interface [polypeptide binding]; other site 656519001214 active site 656519001215 zinc binding site [ion binding]; other site 656519001216 Na+ binding site [ion binding]; other site 656519001217 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 656519001218 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 656519001219 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 656519001220 transcription termination factor Rho; Provisional; Region: rho; PRK09376 656519001221 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 656519001222 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 656519001223 RNA binding site [nucleotide binding]; other site 656519001224 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 656519001225 multimer interface [polypeptide binding]; other site 656519001226 Walker A motif; other site 656519001227 ATP binding site [chemical binding]; other site 656519001228 Walker B motif; other site 656519001229 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 656519001230 Thymidine kinase; Region: TK; cl00631 656519001231 peptide chain release factor 1; Validated; Region: prfA; PRK00591 656519001232 RF-1 domain; Region: RF-1; cl02875 656519001233 RF-1 domain; Region: RF-1; cl02875 656519001234 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 656519001235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 656519001236 S-adenosylmethionine binding site [chemical binding]; other site 656519001237 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 656519001238 SUA5 domain; Region: SUA5; pfam03481 656519001239 Low molecular weight phosphatase family; Region: LMWPc; cd00115 656519001240 Active site [active] 656519001241 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 656519001242 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 656519001243 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 656519001244 Mg++ binding site [ion binding]; other site 656519001245 putative catalytic motif [active] 656519001246 substrate binding site [chemical binding]; other site 656519001247 ATP synthase A chain; Region: ATP-synt_A; cl00413 656519001248 ATP synthase subunit C; Region: ATP-synt_C; cl00466 656519001249 ATP synthase subunit C; Region: ATP-synt_C; cl00466 656519001250 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 656519001251 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 656519001252 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 656519001253 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 656519001254 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 656519001255 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 656519001256 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 656519001257 beta subunit interaction interface [polypeptide binding]; other site 656519001258 Walker A motif; other site 656519001259 ATP binding site [chemical binding]; other site 656519001260 Walker B motif; other site 656519001261 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 656519001262 ATP synthase; Region: ATP-synt; cl00365 656519001263 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 656519001264 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 656519001265 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 656519001266 alpha subunit interaction interface [polypeptide binding]; other site 656519001267 Walker A motif; other site 656519001268 ATP binding site [chemical binding]; other site 656519001269 Walker B motif; other site 656519001270 inhibitor binding site; inhibition site 656519001271 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 656519001272 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 656519001273 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 656519001274 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 656519001275 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 656519001276 hinge; other site 656519001277 active site 656519001278 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 656519001279 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 656519001280 putative substrate binding site [chemical binding]; other site 656519001281 putative ATP binding site [chemical binding]; other site 656519001282 FOG: CBS domain [General function prediction only]; Region: COG0517 656519001283 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 656519001284 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 656519001285 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 656519001286 rod shape-determining protein MreB; Provisional; Region: PRK13930 656519001287 Cell division protein FtsA; Region: FtsA; cl11496 656519001288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 656519001289 Family of unknown function (DUF490); Region: DUF490; pfam04357 656519001290 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 656519001291 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 656519001292 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 656519001293 Surface antigen; Region: Bac_surface_Ag; cl03097 656519001294 Outer membrane protein (OmpH-like); Region: OmpH; cl08146 656519001295 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 656519001296 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 656519001297 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352 656519001298 trimer interface [polypeptide binding]; other site 656519001299 active site 656519001300 UDP-GlcNAc binding site [chemical binding]; other site 656519001301 lipid binding site [chemical binding]; lipid-binding site 656519001302 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 656519001303 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 656519001304 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 656519001305 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 656519001306 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351 656519001307 active site 656519001308 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 656519001309 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 656519001310 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 656519001311 OstA-like protein; Region: OstA; cl00844 656519001312 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 656519001313 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 656519001314 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 656519001315 Walker A/P-loop; other site 656519001316 ATP binding site [chemical binding]; other site 656519001317 Q-loop/lid; other site 656519001318 ABC transporter signature motif; other site 656519001319 Walker B; other site 656519001320 D-loop; other site 656519001321 H-loop/switch region; other site 656519001322 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 656519001323 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 656519001324 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 656519001325 Protein of unknown function (DUF3714); Region: DUF3714; cl13888 656519001326 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 656519001327 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 656519001328 S-layer homology domain; Region: SLH; pfam00395 656519001329 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 656519001330 Autotransporter beta-domain; Region: Autotransporter; cl02365 656519001331 Integrase core domain; Region: rve; cl01316 656519001332 S-layer homology domain; Region: SLH; pfam00395 656519001333 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 656519001334 aspartate racemase; Region: asp_race; TIGR00035 656519001335 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 656519001336 active site 656519001337 metal binding site [ion binding]; metal-binding site 656519001338 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 656519001339 Cation transport protein; Region: TrkH; cl10514 656519001340 S-layer homology domain; Region: SLH; pfam00395 656519001341 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519001342 putative active site [active] 656519001343 heme pocket [chemical binding]; other site 656519001344 putative diguanylate cyclase; Provisional; Region: PRK09776 656519001345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519001346 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 656519001347 putative active site [active] 656519001348 heme pocket [chemical binding]; other site 656519001349 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519001350 putative active site [active] 656519001351 heme pocket [chemical binding]; other site 656519001352 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 656519001353 GAF domain; Region: GAF; cl00853 656519001354 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519001355 metal binding site [ion binding]; metal-binding site 656519001356 active site 656519001357 I-site; other site 656519001358 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519001359 Zn2+ binding site [ion binding]; other site 656519001360 Mg2+ binding site [ion binding]; other site 656519001361 S-layer homology domain; Region: SLH; pfam00395 656519001362 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 656519001363 Probable transposase; Region: OrfB_IS605; pfam01385 656519001364 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 656519001365 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 656519001366 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 656519001367 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 656519001368 active site 656519001369 substrate binding site [chemical binding]; other site 656519001370 metal binding site [ion binding]; metal-binding site 656519001371 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 656519001372 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 656519001373 nucleophile elbow; other site 656519001374 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 656519001375 active site 656519001376 tetramer interface [polypeptide binding]; other site 656519001377 Uncharacterized Fe-S oxidoreductase [Energy production and conversion]; Region: COG1031 656519001378 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 656519001379 Sporulation related domain; Region: SPOR; cl10051 656519001380 Stage II sporulation protein; Region: SpoIID; cl07201 656519001381 Predicted periplasmic protein (DUF2233); Region: DUF2233; cl10481 656519001382 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 656519001383 putative ribose interaction site [chemical binding]; other site 656519001384 putative ADP binding site [chemical binding]; other site 656519001385 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 656519001386 active site 656519001387 nucleotide binding site [chemical binding]; other site 656519001388 HIGH motif; other site 656519001389 KMSKS motif; other site 656519001390 RNA polymerase factor sigma-70; Validated; Region: PRK08295 656519001391 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 656519001392 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 656519001393 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 656519001394 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 656519001395 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 656519001396 30S subunit binding site; other site 656519001397 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 656519001398 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 656519001399 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 656519001400 active site 656519001401 catalytic triad [active] 656519001402 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 656519001403 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 656519001404 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 656519001405 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 656519001406 OstA-like protein; Region: OstA; cl00844 656519001407 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 656519001408 active site 656519001409 catalytic triad [active] 656519001410 dimer interface [polypeptide binding]; other site 656519001411 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 656519001412 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519001413 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 656519001414 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519001415 metal binding site [ion binding]; metal-binding site 656519001416 active site 656519001417 I-site; other site 656519001418 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 656519001419 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 656519001420 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 656519001421 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 656519001422 nucleotide binding region [chemical binding]; other site 656519001423 ATP-binding site [chemical binding]; other site 656519001424 peptide chain release factor 2; Validated; Region: prfB; PRK00578 656519001425 RF-1 domain; Region: RF-1; cl02875 656519001426 RF-1 domain; Region: RF-1; cl02875 656519001427 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 656519001428 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 656519001429 Uncharacterized conserved protein [Function unknown]; Region: COG1284 656519001430 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 656519001431 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 656519001432 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 656519001433 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 656519001434 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 656519001435 protein binding site [polypeptide binding]; other site 656519001436 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 656519001437 Catalytic dyad [active] 656519001438 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 656519001439 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 656519001440 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 656519001441 putative L-serine binding site [chemical binding]; other site 656519001442 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 656519001443 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 656519001444 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 656519001445 putative proton transfer pathway, P2; other site 656519001446 excinuclease ABC subunit B; Provisional; Region: PRK05298 656519001447 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 656519001448 ATP binding site [chemical binding]; other site 656519001449 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 656519001450 nucleotide binding region [chemical binding]; other site 656519001451 ATP-binding site [chemical binding]; other site 656519001452 Ultra-violet resistance protein B; Region: UvrB; pfam12344 656519001453 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 656519001454 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 656519001455 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 656519001456 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 656519001457 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 656519001458 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 656519001459 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 656519001460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519001461 dimer interface [polypeptide binding]; other site 656519001462 conserved gate region; other site 656519001463 ABC-ATPase subunit interface; other site 656519001464 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 656519001465 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 656519001466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519001467 dimer interface [polypeptide binding]; other site 656519001468 conserved gate region; other site 656519001469 putative PBP binding loops; other site 656519001470 ABC-ATPase subunit interface; other site 656519001471 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 656519001472 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 656519001473 Walker A/P-loop; other site 656519001474 ATP binding site [chemical binding]; other site 656519001475 Q-loop/lid; other site 656519001476 ABC transporter signature motif; other site 656519001477 Walker B; other site 656519001478 D-loop; other site 656519001479 H-loop/switch region; other site 656519001480 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 656519001481 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 656519001482 Walker A/P-loop; other site 656519001483 ATP binding site [chemical binding]; other site 656519001484 Q-loop/lid; other site 656519001485 ABC transporter signature motif; other site 656519001486 Walker B; other site 656519001487 D-loop; other site 656519001488 H-loop/switch region; other site 656519001489 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 656519001490 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 656519001491 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 656519001492 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 656519001493 active site 656519001494 catalytic site [active] 656519001495 metal binding site [ion binding]; metal-binding site 656519001496 dimer interface [polypeptide binding]; other site 656519001497 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 656519001498 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 656519001499 DctM-like transporters; Region: DctM; pfam06808 656519001500 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519001501 MgtC family; Region: MgtC; cl12207 656519001502 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 656519001503 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 656519001504 active site 656519001505 catalytic site [active] 656519001506 metal binding site [ion binding]; metal-binding site 656519001507 dimer interface [polypeptide binding]; other site 656519001508 Transposase IS200 like; Region: Y1_Tnp; cl00848 656519001509 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 656519001510 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 656519001511 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209 656519001512 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 656519001513 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 656519001514 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 656519001515 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 656519001516 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 656519001517 GSH binding site [chemical binding]; other site 656519001518 catalytic residues [active] 656519001519 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 656519001520 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519001521 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519001522 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 656519001523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519001524 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 656519001525 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 656519001526 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 656519001527 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 656519001528 Transcriptional regulators [Transcription]; Region: GntR; COG1802 656519001529 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656519001530 DNA-binding site [nucleotide binding]; DNA binding site 656519001531 FCD domain; Region: FCD; cl11656 656519001532 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 656519001533 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519001534 Zn2+ binding site [ion binding]; other site 656519001535 Mg2+ binding site [ion binding]; other site 656519001536 PAS domain S-box; Region: sensory_box; TIGR00229 656519001537 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519001538 putative active site [active] 656519001539 heme pocket [chemical binding]; other site 656519001540 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519001541 metal binding site [ion binding]; metal-binding site 656519001542 active site 656519001543 I-site; other site 656519001544 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519001545 Zn2+ binding site [ion binding]; other site 656519001546 Mg2+ binding site [ion binding]; other site 656519001547 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519001548 PAS fold; Region: PAS_3; pfam08447 656519001549 putative active site [active] 656519001550 heme pocket [chemical binding]; other site 656519001551 two-component VirA-like sensor kinase; Provisional; Region: PRK13837 656519001552 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 656519001553 Glycerate kinase family; Region: Gly_kinase; cl00841 656519001554 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 656519001555 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 656519001556 active site 656519001557 dimer interface [polypeptide binding]; other site 656519001558 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 656519001559 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 656519001560 active site 656519001561 FMN binding site [chemical binding]; other site 656519001562 substrate binding site [chemical binding]; other site 656519001563 3Fe-4S cluster binding site [ion binding]; other site 656519001564 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 656519001565 domain interface; other site 656519001566 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 656519001567 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519001568 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 656519001569 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 656519001570 substrate binding pocket [chemical binding]; other site 656519001571 membrane-bound complex binding site; other site 656519001572 hinge residues; other site 656519001573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 656519001574 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 656519001575 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 656519001576 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 656519001577 Walker A/P-loop; other site 656519001578 ATP binding site [chemical binding]; other site 656519001579 Q-loop/lid; other site 656519001580 ABC transporter signature motif; other site 656519001581 Walker B; other site 656519001582 D-loop; other site 656519001583 H-loop/switch region; other site 656519001584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519001585 dimer interface [polypeptide binding]; other site 656519001586 conserved gate region; other site 656519001587 putative PBP binding loops; other site 656519001588 ABC-ATPase subunit interface; other site 656519001589 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 656519001590 FAD binding domain; Region: FAD_binding_4; pfam01565 656519001591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656519001592 putative substrate translocation pore; other site 656519001593 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 656519001594 Ligand binding site [chemical binding]; other site 656519001595 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 656519001596 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 656519001597 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 656519001598 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 656519001599 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 656519001600 NADP binding site [chemical binding]; other site 656519001601 homodimer interface [polypeptide binding]; other site 656519001602 active site 656519001603 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 656519001604 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 656519001605 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 656519001606 BCCT family transporter; Region: BCCT; cl00569 656519001607 Survival protein SurE; Region: SurE; cl00448 656519001608 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 656519001609 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 656519001610 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 656519001611 active site 656519001612 nucleophile elbow; other site 656519001613 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 656519001614 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 656519001615 Response regulator receiver domain; Region: Response_reg; pfam00072 656519001616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 656519001617 active site 656519001618 phosphorylation site [posttranslational modification] 656519001619 intermolecular recognition site; other site 656519001620 dimerization interface [polypeptide binding]; other site 656519001621 Histidine kinase; Region: His_kinase; pfam06580 656519001622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656519001623 ATP binding site [chemical binding]; other site 656519001624 Mg2+ binding site [ion binding]; other site 656519001625 G-X-G motif; other site 656519001626 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519001627 metal binding site [ion binding]; metal-binding site 656519001628 active site 656519001629 I-site; other site 656519001630 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 656519001631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 656519001632 active site 656519001633 phosphorylation site [posttranslational modification] 656519001634 intermolecular recognition site; other site 656519001635 dimerization interface [polypeptide binding]; other site 656519001636 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209 656519001637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 656519001638 active site 656519001639 phosphorylation site [posttranslational modification] 656519001640 intermolecular recognition site; other site 656519001641 dimerization interface [polypeptide binding]; other site 656519001642 FecR protein; Region: FecR; pfam04773 656519001643 putative diguanylate cyclase; Provisional; Region: PRK09776 656519001644 PAS domain S-box; Region: sensory_box; TIGR00229 656519001645 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 656519001646 PAS domain S-box; Region: sensory_box; TIGR00229 656519001647 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519001648 metal binding site [ion binding]; metal-binding site 656519001649 active site 656519001650 I-site; other site 656519001651 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519001652 Zn2+ binding site [ion binding]; other site 656519001653 Mg2+ binding site [ion binding]; other site 656519001654 putative transposase OrfB; Reviewed; Region: PHA02517 656519001655 Integrase core domain; Region: rve; cl01316 656519001656 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519001657 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which...; Region: B_lectin; cl00039 656519001658 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 656519001659 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 656519001660 FOG: WD40-like repeat [Function unknown]; Region: COG1520 656519001661 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 656519001662 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 656519001663 putative active site [active] 656519001664 putative NTP binding site [chemical binding]; other site 656519001665 putative nucleic acid binding site [nucleotide binding]; other site 656519001666 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 656519001667 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 656519001668 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519001669 putative transposase OrfB; Reviewed; Region: PHA02517 656519001670 Integrase core domain; Region: rve; cl01316 656519001671 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 656519001672 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 656519001673 Chain length determinant protein; Region: Wzz; cl01623 656519001674 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 656519001675 Chain length determinant protein; Region: Wzz; cl01623 656519001676 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 656519001677 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 656519001678 SLBB domain; Region: SLBB; pfam10531 656519001679 SLBB domain; Region: SLBB; pfam10531 656519001680 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 656519001681 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 656519001682 PHP domain; Region: PHP; pfam02811 656519001683 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 656519001684 Preprotein translocase subunit SecA (ATPase, RNA helicase) [Intracellular trafficking and secretion]; Region: SecA; COG0653 656519001685 NUP50 (Nucleoporin 50 kDa); Region: NUP50; pfam08911 656519001686 SEC-C motif; Region: SEC-C; cl12132 656519001687 Propionate catabolism activator; Region: PrpR_N; pfam06506 656519001688 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 656519001689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519001690 Walker A motif; other site 656519001691 ATP binding site [chemical binding]; other site 656519001692 Walker B motif; other site 656519001693 arginine finger; other site 656519001694 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 656519001695 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 656519001696 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 656519001697 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 656519001698 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 656519001699 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 656519001700 inhibitor site; inhibition site 656519001701 active site 656519001702 dimer interface [polypeptide binding]; other site 656519001703 catalytic residue [active] 656519001704 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 656519001705 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 656519001706 putative active site [active] 656519001707 metal binding site [ion binding]; metal-binding site 656519001708 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 656519001709 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 656519001710 DctM-like transporters; Region: DctM; pfam06808 656519001711 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519001712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656519001713 putative substrate translocation pore; other site 656519001714 Major Facilitator Superfamily; Region: MFS_1; pfam07690 656519001715 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 656519001716 classical (c) SDRs; Region: SDR_c; cd05233 656519001717 NAD(P) binding site [chemical binding]; other site 656519001718 active site 656519001719 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 656519001720 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519001721 Integrase core domain; Region: rve; cl01316 656519001722 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 656519001723 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 656519001724 putative ADP-binding pocket [chemical binding]; other site 656519001725 Bacterial sugar transferase; Region: Bac_transf; cl00939 656519001726 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 656519001727 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 656519001728 inhibitor-cofactor binding pocket; inhibition site 656519001729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519001730 catalytic residue [active] 656519001731 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519001732 putative transposase OrfB; Reviewed; Region: PHA02517 656519001733 Integrase core domain; Region: rve; cl01316 656519001734 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 656519001735 putative ADP-binding pocket [chemical binding]; other site 656519001736 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 656519001737 Integrase core domain; Region: rve; cl01316 656519001738 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 656519001739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519001740 NAD(P) binding site [chemical binding]; other site 656519001741 active site 656519001742 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 656519001743 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 656519001744 Substrate binding site [chemical binding]; other site 656519001745 Cupin domain; Region: Cupin_2; cl09118 656519001746 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 656519001747 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 656519001748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 656519001749 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 656519001750 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 656519001751 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519001752 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 656519001753 ADP-ribose binding site [chemical binding]; other site 656519001754 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 656519001755 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656519001756 non-specific DNA binding site [nucleotide binding]; other site 656519001757 salt bridge; other site 656519001758 sequence-specific DNA binding site [nucleotide binding]; other site 656519001759 Domain of unknown function (DUF955); Region: DUF955; cl01076 656519001760 HIRAN domain; Region: HIRAN; pfam08797 656519001761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 656519001762 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 656519001763 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519001764 Integrase core domain; Region: rve; cl01316 656519001765 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 656519001766 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 656519001767 NAD(P) binding site [chemical binding]; other site 656519001768 homodimer interface [polypeptide binding]; other site 656519001769 substrate binding site [chemical binding]; other site 656519001770 active site 656519001771 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 656519001772 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 656519001773 transposase; Provisional; Region: PRK06526 656519001774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519001775 Walker A motif; other site 656519001776 ATP binding site [chemical binding]; other site 656519001777 Walker B motif; other site 656519001778 Transposase IS200 like; Region: Y1_Tnp; cl00848 656519001779 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519001780 fibrous body protein; Provisional; Region: P10; PHA03386 656519001781 putative transposase OrfB; Reviewed; Region: PHA02517 656519001782 Integrase core domain; Region: rve; cl01316 656519001783 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519001784 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 656519001785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 656519001786 active site 656519001787 phosphorylation site [posttranslational modification] 656519001788 intermolecular recognition site; other site 656519001789 dimerization interface [polypeptide binding]; other site 656519001790 LytTr DNA-binding domain; Region: LytTR; cl04498 656519001791 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 656519001792 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 656519001793 Histidine kinase; Region: His_kinase; pfam06580 656519001794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 656519001795 Predicted TIM-barrel enzyme, possibly a dioxygenase [General function prediction only]; Region: COG5564 656519001796 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 656519001797 Probable transposase; Region: OrfB_IS605; pfam01385 656519001798 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 656519001799 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 656519001800 Predicted TIM-barrel enzyme, possibly a dioxygenase [General function prediction only]; Region: COG5564 656519001801 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 656519001802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519001803 Walker A motif; other site 656519001804 ATP binding site [chemical binding]; other site 656519001805 Walker B motif; other site 656519001806 arginine finger; other site 656519001807 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 656519001808 Uncharacterised protein family (UPF0261); Region: UPF0261; cl02262 656519001809 Predicted TIM-barrel enzyme, possibly a dioxygenase [General function prediction only]; Region: COG5564 656519001810 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 656519001811 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 656519001812 transmembrane helices; other site 656519001813 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 656519001814 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 656519001815 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 656519001816 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519001817 Walker A/P-loop; other site 656519001818 ATP binding site [chemical binding]; other site 656519001819 Q-loop/lid; other site 656519001820 ABC transporter signature motif; other site 656519001821 Walker B; other site 656519001822 D-loop; other site 656519001823 H-loop/switch region; other site 656519001824 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 656519001825 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 656519001826 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 656519001827 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 656519001828 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 656519001829 substrate binding site [chemical binding]; other site 656519001830 tetramer interface [polypeptide binding]; other site 656519001831 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 656519001832 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 656519001833 NAD binding site [chemical binding]; other site 656519001834 putative substrate binding site 2 [chemical binding]; other site 656519001835 putative substrate binding site 1 [chemical binding]; other site 656519001836 active site 656519001837 Cupin domain; Region: Cupin_2; cl09118 656519001838 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 656519001839 active site 656519001840 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 656519001841 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 656519001842 NADP binding site [chemical binding]; other site 656519001843 active site 656519001844 putative substrate binding site [chemical binding]; other site 656519001845 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 656519001846 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 656519001847 Probable Catalytic site [active] 656519001848 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 656519001849 Probable Catalytic site [active] 656519001850 metal binding site [ion binding]; metal-binding site 656519001851 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 656519001852 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 656519001853 NAD binding site [chemical binding]; other site 656519001854 substrate binding site [chemical binding]; other site 656519001855 homodimer interface [polypeptide binding]; other site 656519001856 active site 656519001857 O-Antigen ligase; Region: Wzy_C; cl04850 656519001858 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 656519001859 DXD motif; other site 656519001860 Bacterial sugar transferase; Region: Bac_transf; cl00939 656519001861 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 656519001862 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 656519001863 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 656519001864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 656519001865 S-adenosylmethionine binding site [chemical binding]; other site 656519001866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656519001867 putative DNA binding site [nucleotide binding]; other site 656519001868 putative Zn2+ binding site [ion binding]; other site 656519001869 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 656519001870 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 656519001871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519001872 Walker A motif; other site 656519001873 ATP binding site [chemical binding]; other site 656519001874 Walker B motif; other site 656519001875 arginine finger; other site 656519001876 PRD domain; Region: PRD; pfam00874 656519001877 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 656519001878 active pocket/dimerization site; other site 656519001879 active site 656519001880 phosphorylation site [posttranslational modification] 656519001881 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 656519001882 active site 656519001883 phosphorylation site [posttranslational modification] 656519001884 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 656519001885 active site 656519001886 phosphorylation site [posttranslational modification] 656519001887 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 656519001888 P-loop; other site 656519001889 active site 656519001890 phosphorylation site [posttranslational modification] 656519001891 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 656519001892 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 656519001893 intersubunit interface [polypeptide binding]; other site 656519001894 active site 656519001895 Zn2+ binding site [ion binding]; other site 656519001896 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 656519001897 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 656519001898 Substrate binding site [chemical binding]; other site 656519001899 Cupin domain; Region: Cupin_2; cl09118 656519001900 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 656519001901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519001902 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 656519001903 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 656519001904 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 656519001905 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 656519001906 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 656519001907 Walker A/P-loop; other site 656519001908 ATP binding site [chemical binding]; other site 656519001909 Q-loop/lid; other site 656519001910 ABC transporter signature motif; other site 656519001911 Walker B; other site 656519001912 D-loop; other site 656519001913 H-loop/switch region; other site 656519001914 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 656519001915 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 656519001916 TM-ABC transporter signature motif; other site 656519001917 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 656519001918 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 656519001919 substrate binding site [chemical binding]; other site 656519001920 active site 656519001921 catalytic residues [active] 656519001922 heterodimer interface [polypeptide binding]; other site 656519001923 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 656519001924 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 656519001925 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 656519001926 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 656519001927 FMN binding site [chemical binding]; other site 656519001928 dimer interface [polypeptide binding]; other site 656519001929 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 656519001930 dimer interface [polypeptide binding]; other site 656519001931 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 656519001932 MgtE intracellular N domain; Region: MgtE_N; cl15244 656519001933 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 656519001934 Divalent cation transporter; Region: MgtE; cl00786 656519001935 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 656519001936 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 656519001937 active site 656519001938 catalytic tetrad [active] 656519001939 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 656519001940 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519001941 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 656519001942 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 656519001943 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519001944 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 656519001945 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 656519001946 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 656519001947 dimer interface [polypeptide binding]; other site 656519001948 active site 656519001949 metal binding site [ion binding]; metal-binding site 656519001950 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 656519001951 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 656519001952 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 656519001953 active site 656519001954 intersubunit interactions; other site 656519001955 catalytic residue [active] 656519001956 transketolase; Reviewed; Region: PRK05899 656519001957 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 656519001958 TPP-binding site [chemical binding]; other site 656519001959 dimer interface [polypeptide binding]; other site 656519001960 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 656519001961 PYR/PP interface [polypeptide binding]; other site 656519001962 dimer interface [polypeptide binding]; other site 656519001963 TPP binding site [chemical binding]; other site 656519001964 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 656519001965 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 656519001966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519001967 NAD(P) binding site [chemical binding]; other site 656519001968 active site 656519001969 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 656519001970 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 656519001971 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 656519001972 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 656519001973 hypothetical protein; Provisional; Region: PRK08185 656519001974 intersubunit interface [polypeptide binding]; other site 656519001975 active site 656519001976 zinc binding site [ion binding]; other site 656519001977 Na+ binding site [ion binding]; other site 656519001978 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 656519001979 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 656519001980 putative NAD(P) binding site [chemical binding]; other site 656519001981 catalytic Zn binding site [ion binding]; other site 656519001982 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 656519001983 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519001984 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 656519001985 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 656519001986 active site 656519001987 metal binding site [ion binding]; metal-binding site 656519001988 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 656519001989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 656519001990 active site 656519001991 motif I; other site 656519001992 motif II; other site 656519001993 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 656519001994 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 656519001995 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 656519001996 Sulfatase; Region: Sulfatase; cl10460 656519001997 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 656519001998 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 656519001999 active site 656519002000 catalytic site [active] 656519002001 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 656519002002 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 656519002003 dimer interface [polypeptide binding]; other site 656519002004 active site 656519002005 metal binding site [ion binding]; metal-binding site 656519002006 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 656519002007 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 656519002008 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 656519002009 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 656519002010 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 656519002011 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 656519002012 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12667 656519002013 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 656519002014 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00144 656519002015 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 656519002016 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 656519002017 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 656519002018 metal binding site [ion binding]; metal-binding site 656519002019 dimer interface [polypeptide binding]; other site 656519002020 tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264 656519002021 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 656519002022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519002023 homodimer interface [polypeptide binding]; other site 656519002024 catalytic residue [active] 656519002025 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 656519002026 Catalytic site; other site 656519002027 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 656519002028 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519002029 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 656519002030 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656519002031 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 656519002032 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 656519002033 Sulfate transporter family; Region: Sulfate_transp; cl00967 656519002034 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 656519002035 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 656519002036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 656519002037 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 656519002038 biotin synthase; Provisional; Region: PRK07094 656519002039 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 656519002040 FeS/SAM binding site; other site 656519002041 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 656519002042 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 656519002043 Sulfate transporter family; Region: Sulfate_transp; cl00967 656519002044 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 656519002045 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 656519002046 transmembrane helices; other site 656519002047 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519002048 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519002049 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 656519002050 Protein of unknown function(DUF2089); Region: DUF2089; pfam09862 656519002051 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl01588 656519002052 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 656519002053 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 656519002054 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 656519002055 dimer interface [polypeptide binding]; other site 656519002056 substrate binding site [chemical binding]; other site 656519002057 ATP binding site [chemical binding]; other site 656519002058 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 656519002059 thiamine phosphate binding site [chemical binding]; other site 656519002060 active site 656519002061 pyrophosphate binding site [ion binding]; other site 656519002062 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 656519002063 substrate binding site [chemical binding]; other site 656519002064 multimerization interface [polypeptide binding]; other site 656519002065 ATP binding site [chemical binding]; other site 656519002066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 656519002067 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 656519002068 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 656519002069 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 656519002070 FeS/SAM binding site; other site 656519002071 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 656519002072 Transposase domain (DUF772); Region: DUF772; cl12084 656519002073 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 656519002074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519002075 Walker A motif; other site 656519002076 ATP binding site [chemical binding]; other site 656519002077 Walker B motif; other site 656519002078 arginine finger; other site 656519002079 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 656519002080 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 656519002081 pyruvate formate-lyase; Region: PFL2-3; TIGR01774 656519002082 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 656519002083 Domain of unknown function (DUF336); Region: DUF336; cl01249 656519002084 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 656519002085 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 656519002086 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 656519002087 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 656519002088 Ubiquitin-like proteins; Region: UBQ; cl00155 656519002089 charged pocket; other site 656519002090 hydrophobic patch; other site 656519002091 hypothetical protein; Provisional; Region: PRK08328 656519002092 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 656519002093 ATP binding site [chemical binding]; other site 656519002094 substrate interface [chemical binding]; other site 656519002095 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 656519002096 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 656519002097 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 656519002098 putative substrate binding site [chemical binding]; other site 656519002099 putative ATP binding site [chemical binding]; other site 656519002100 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 656519002101 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 656519002102 ANP binding site [chemical binding]; other site 656519002103 Substrate Binding Site II [chemical binding]; other site 656519002104 Substrate Binding Site I [chemical binding]; other site 656519002105 argininosuccinate lyase; Provisional; Region: PRK00855 656519002106 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 656519002107 active sites [active] 656519002108 tetramer interface [polypeptide binding]; other site 656519002109 Peptidase family M48; Region: Peptidase_M48; cl12018 656519002110 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 656519002111 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 656519002112 Cl- selectivity filter; other site 656519002113 Cl- binding residues [ion binding]; other site 656519002114 pore gating glutamate residue; other site 656519002115 dimer interface [polypeptide binding]; other site 656519002116 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 656519002117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519002118 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656519002119 dimerization interface [polypeptide binding]; other site 656519002120 putative DNA binding site [nucleotide binding]; other site 656519002121 putative Zn2+ binding site [ion binding]; other site 656519002122 Transposase IS200 like; Region: Y1_Tnp; cl00848 656519002123 Transposase, Mutator family; Region: Transposase_mut; pfam00872 656519002124 MULE transposase domain; Region: MULE; pfam10551 656519002125 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 656519002126 substrate binding site [chemical binding]; other site 656519002127 ATP binding site [chemical binding]; other site 656519002128 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 656519002129 mannose-6-phosphate isomerase; Provisional; Region: PRK15131; cl14659 656519002130 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519002131 Transcriptional regulator [Transcription]; Region: IclR; COG1414 656519002132 Bacterial transcriptional regulator; Region: IclR; pfam01614 656519002133 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083 656519002134 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 656519002135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 656519002136 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083 656519002137 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 656519002138 fumarate hydratase; Reviewed; Region: fumC; PRK00485 656519002139 Class II fumarases; Region: Fumarase_classII; cd01362 656519002140 active site 656519002141 tetramer interface [polypeptide binding]; other site 656519002142 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519002143 Zn2+ binding site [ion binding]; other site 656519002144 Mg2+ binding site [ion binding]; other site 656519002145 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656519002146 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656519002147 Cupin domain; Region: Cupin_2; cl09118 656519002148 Outer membrane efflux protein; Region: OEP; pfam02321 656519002149 Outer membrane efflux protein; Region: OEP; pfam02321 656519002150 Outer membrane efflux protein; Region: OEP; pfam02321 656519002151 Outer membrane efflux protein; Region: OEP; pfam02321 656519002152 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 656519002153 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 656519002154 Protein export membrane protein; Region: SecD_SecF; cl14618 656519002155 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 656519002156 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 656519002157 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 656519002158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519002159 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 656519002160 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 656519002161 feedback inhibition sensing region; other site 656519002162 homohexameric interface [polypeptide binding]; other site 656519002163 nucleotide binding site [chemical binding]; other site 656519002164 N-acetyl-L-glutamate binding site [chemical binding]; other site 656519002165 acetylornithine aminotransferase; Provisional; Region: PRK02627 656519002166 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 656519002167 inhibitor-cofactor binding pocket; inhibition site 656519002168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519002169 catalytic residue [active] 656519002170 hypothetical protein; Provisional; Region: PRK05590 656519002171 SEC-C motif; Region: SEC-C; cl12132 656519002172 Predicted membrane protein [Function unknown]; Region: COG4684 656519002173 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 656519002174 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 656519002175 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 656519002176 motif II; other site 656519002177 Mechanosensitive ion channel; Region: MS_channel; pfam00924 656519002178 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 656519002179 conserved cys residue [active] 656519002180 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 656519002181 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 656519002182 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 656519002183 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 656519002184 putative ADP-binding pocket [chemical binding]; other site 656519002185 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 656519002186 substrate binding site [chemical binding]; other site 656519002187 ATP binding site [chemical binding]; other site 656519002188 pullulanase, type I; Region: pulA_typeI; TIGR02104 656519002189 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 656519002190 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 656519002191 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 656519002192 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 656519002193 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 656519002194 ligand binding site [chemical binding]; other site 656519002195 oligomer interface [polypeptide binding]; other site 656519002196 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 656519002197 dimer interface [polypeptide binding]; other site 656519002198 N-terminal domain interface [polypeptide binding]; other site 656519002199 sulfate 1 binding site; other site 656519002200 glycogen branching enzyme; Provisional; Region: PRK12313 656519002201 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 656519002202 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 656519002203 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 656519002204 glycogen synthase; Provisional; Region: glgA; PRK00654 656519002205 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 656519002206 ADP-binding pocket [chemical binding]; other site 656519002207 homodimer interface [polypeptide binding]; other site 656519002208 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 656519002209 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of...; Region: L-fuc_L-ara-isomerases; cl00947 656519002210 substrate binding site [chemical binding]; other site 656519002211 trimer interface [polypeptide binding]; other site 656519002212 hexamer (dimer of trimers) interface [polypeptide binding]; other site 656519002213 Mn binding site [ion binding]; other site 656519002214 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 656519002215 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519002216 Walker A/P-loop; other site 656519002217 ATP binding site [chemical binding]; other site 656519002218 Q-loop/lid; other site 656519002219 ABC transporter signature motif; other site 656519002220 Walker B; other site 656519002221 D-loop; other site 656519002222 H-loop/switch region; other site 656519002223 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 656519002224 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656519002225 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 656519002226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 656519002227 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 656519002228 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 656519002229 Walker A/P-loop; other site 656519002230 ATP binding site [chemical binding]; other site 656519002231 Q-loop/lid; other site 656519002232 ABC transporter signature motif; other site 656519002233 Walker B; other site 656519002234 D-loop; other site 656519002235 H-loop/switch region; other site 656519002236 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 656519002237 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519002238 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 656519002239 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519002240 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 656519002241 Uncharacterized conserved protein [Function unknown]; Region: COG3461 656519002242 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 656519002243 Radical SAM; Region: Elp3; smart00729 656519002244 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 656519002245 FeS/SAM binding site; other site 656519002246 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 656519002247 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 656519002248 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656519002249 catalytic residue [active] 656519002250 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 656519002251 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 656519002252 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656519002253 catalytic residue [active] 656519002254 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 656519002255 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 656519002256 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 656519002257 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 656519002258 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 656519002259 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 656519002260 active site 656519002261 homodimer interface [polypeptide binding]; other site 656519002262 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 656519002263 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 656519002264 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 656519002265 dimer interface [polypeptide binding]; other site 656519002266 PYR/PP interface [polypeptide binding]; other site 656519002267 TPP binding site [chemical binding]; other site 656519002268 substrate binding site [chemical binding]; other site 656519002269 2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11869 656519002270 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 656519002271 TPP-binding site [chemical binding]; other site 656519002272 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 656519002273 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 656519002274 diiron binding motif [ion binding]; other site 656519002275 hybrid cluster protein; Provisional; Region: PRK05290 656519002276 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 656519002277 ACS interaction site; other site 656519002278 CODH interaction site; other site 656519002279 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 656519002280 hybrid metal cluster; other site 656519002281 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 656519002282 active site 656519002283 catalytic residues [active] 656519002284 hydrogenase maturation GTPase HydF; Region: GTP_HydF; TIGR03918 656519002285 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 656519002286 G1 box; other site 656519002287 GTP/Mg2+ binding site [chemical binding]; other site 656519002288 Switch I region; other site 656519002289 G2 box; other site 656519002290 Switch II region; other site 656519002291 G3 box; other site 656519002292 G4 box; other site 656519002293 G5 box; other site 656519002294 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 656519002295 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 656519002296 Walker A/P-loop; other site 656519002297 ATP binding site [chemical binding]; other site 656519002298 Q-loop/lid; other site 656519002299 ABC transporter signature motif; other site 656519002300 Walker B; other site 656519002301 D-loop; other site 656519002302 H-loop/switch region; other site 656519002303 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 656519002304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519002305 dimer interface [polypeptide binding]; other site 656519002306 conserved gate region; other site 656519002307 ABC-ATPase subunit interface; other site 656519002308 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 656519002309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519002310 dimer interface [polypeptide binding]; other site 656519002311 conserved gate region; other site 656519002312 ABC-ATPase subunit interface; other site 656519002313 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656519002314 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 656519002315 Aspartase; Region: Aspartase; cd01357 656519002316 active sites [active] 656519002317 tetramer interface [polypeptide binding]; other site 656519002318 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 656519002319 Probable transposase; Region: OrfB_IS605; pfam01385 656519002320 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 656519002321 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 656519002322 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 656519002323 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 656519002324 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 656519002325 active site residue [active] 656519002326 RnfE family; Region: NQR2_RnfD_RnfE; cl00779 656519002327 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 656519002328 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 656519002329 ligand binding site [chemical binding]; other site 656519002330 flexible hinge region; other site 656519002331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519002332 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 656519002333 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656519002334 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 656519002335 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 656519002336 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519002337 Walker A/P-loop; other site 656519002338 ATP binding site [chemical binding]; other site 656519002339 Q-loop/lid; other site 656519002340 ABC transporter signature motif; other site 656519002341 Walker B; other site 656519002342 D-loop; other site 656519002343 H-loop/switch region; other site 656519002344 DAK2 domain; Region: Dak2; cl03685 656519002345 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 656519002346 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 656519002347 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 656519002348 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (; Region: GT1_wlbH_like; cd03798 656519002349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519002350 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 656519002351 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 656519002352 Putative cyclase; Region: Cyclase; cl00814 656519002353 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 656519002354 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 656519002355 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 656519002356 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 656519002357 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 656519002358 Transcriptional regulators [Transcription]; Region: MarR; COG1846 656519002359 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519002360 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 656519002361 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 656519002362 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 656519002363 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 656519002364 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 656519002365 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 656519002366 dimer interface [polypeptide binding]; other site 656519002367 glycine-pyridoxal phosphate binding site [chemical binding]; other site 656519002368 active site 656519002369 folate binding site [chemical binding]; other site 656519002370 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 656519002371 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 656519002372 active site 656519002373 motif I; other site 656519002374 motif II; other site 656519002375 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 656519002376 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 656519002377 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 656519002378 HPr kinase/phosphorylase; Provisional; Region: PRK05428 656519002379 DRTGG domain; Region: DRTGG; cl12147 656519002380 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 656519002381 Hpr binding site; other site 656519002382 active site 656519002383 homohexamer subunit interaction site [polypeptide binding]; other site 656519002384 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 656519002385 putative ligand binding site [chemical binding]; other site 656519002386 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 656519002387 substrate binding pocket [chemical binding]; other site 656519002388 substrate-Mg2+ binding site; other site 656519002389 aspartate-rich region 1; other site 656519002390 aspartate-rich region 2; other site 656519002391 P-loop ATPase protein family; Region: ATP_bind_2; cl10035 656519002392 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 656519002393 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 656519002394 phosphate binding site [ion binding]; other site 656519002395 putative substrate binding pocket [chemical binding]; other site 656519002396 dimer interface [polypeptide binding]; other site 656519002397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 656519002398 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 656519002399 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 656519002400 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 656519002401 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 656519002402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519002403 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 656519002404 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 656519002405 substrate binding site [chemical binding]; other site 656519002406 hinge regions; other site 656519002407 ADP binding site [chemical binding]; other site 656519002408 catalytic site [active] 656519002409 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 656519002410 substrate binding site [chemical binding]; other site 656519002411 dimer interface [polypeptide binding]; other site 656519002412 catalytic triad [active] 656519002413 Sulfatase; Region: Sulfatase; cl10460 656519002414 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 656519002415 enolase; Provisional; Region: eno; PRK00077 656519002416 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 656519002417 dimer interface [polypeptide binding]; other site 656519002418 metal binding site [ion binding]; metal-binding site 656519002419 substrate binding pocket [chemical binding]; other site 656519002420 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 656519002421 GAF domain; Region: GAF; cl00853 656519002422 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519002423 Zn2+ binding site [ion binding]; other site 656519002424 Mg2+ binding site [ion binding]; other site 656519002425 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656519002426 Transposase, Mutator family; Region: Transposase_mut; pfam00872 656519002427 MULE transposase domain; Region: MULE; pfam10551 656519002428 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 656519002429 Outer membrane efflux protein; Region: OEP; pfam02321 656519002430 Outer membrane efflux protein; Region: OEP; pfam02321 656519002431 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 656519002432 Outer membrane efflux protein; Region: OEP; pfam02321 656519002433 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 656519002434 Preprotein translocase SecG subunit; Region: SecG; cl09123 656519002435 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 656519002436 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 656519002437 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 656519002438 CoenzymeA binding site [chemical binding]; other site 656519002439 subunit interaction site [polypeptide binding]; other site 656519002440 PHB binding site; other site 656519002441 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 656519002442 ribonuclease R; Region: RNase_R; TIGR02063 656519002443 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 656519002444 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 656519002445 RNB domain; Region: RNB; pfam00773 656519002446 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 656519002447 RNA binding site [nucleotide binding]; other site 656519002448 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 656519002449 SmpB-tmRNA interface; other site 656519002450 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519002451 putative active site [active] 656519002452 heme pocket [chemical binding]; other site 656519002453 hypothetical protein; Provisional; Region: PRK13560 656519002454 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519002455 metal binding site [ion binding]; metal-binding site 656519002456 active site 656519002457 I-site; other site 656519002458 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519002459 Zn2+ binding site [ion binding]; other site 656519002460 Mg2+ binding site [ion binding]; other site 656519002461 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 656519002462 Mechanosensitive ion channel; Region: MS_channel; pfam00924 656519002463 Protein of unknown function (DUF503); Region: DUF503; cl00669 656519002464 Chromate transporter; Region: Chromate_transp; pfam02417 656519002465 Chromate transporter; Region: Chromate_transp; pfam02417 656519002466 ABC-2 type transporter; Region: ABC2_membrane; cl11417 656519002467 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 656519002468 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519002469 Walker A/P-loop; other site 656519002470 ATP binding site [chemical binding]; other site 656519002471 Q-loop/lid; other site 656519002472 ABC transporter signature motif; other site 656519002473 Walker B; other site 656519002474 D-loop; other site 656519002475 H-loop/switch region; other site 656519002476 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 656519002477 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519002478 putative active site [active] 656519002479 heme pocket [chemical binding]; other site 656519002480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 656519002481 dimer interface [polypeptide binding]; other site 656519002482 phosphorylation site [posttranslational modification] 656519002483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656519002484 ATP binding site [chemical binding]; other site 656519002485 Mg2+ binding site [ion binding]; other site 656519002486 G-X-G motif; other site 656519002487 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 656519002488 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 656519002489 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 656519002490 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 656519002491 active site 656519002492 metal binding site [ion binding]; metal-binding site 656519002493 Sporulation and spore germination; Region: Germane; pfam10646 656519002494 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 656519002495 ribonuclease PH; Reviewed; Region: rph; PRK00173 656519002496 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 656519002497 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 656519002498 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 656519002499 active site 656519002500 dimerization interface [polypeptide binding]; other site 656519002501 YibE/F-like protein; Region: YibE_F; cl02259 656519002502 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519002503 metal binding site [ion binding]; metal-binding site 656519002504 active site 656519002505 I-site; other site 656519002506 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 656519002507 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656519002508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656519002509 trigger factor; Provisional; Region: tig; PRK01490 656519002510 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 656519002511 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 656519002512 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 656519002513 oligomer interface [polypeptide binding]; other site 656519002514 active site residues [active] 656519002515 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 656519002516 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 656519002517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519002518 Walker A motif; other site 656519002519 ATP binding site [chemical binding]; other site 656519002520 Walker B motif; other site 656519002521 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 656519002522 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 656519002523 Found in ATP-dependent protease La (LON); Region: LON; cl01056 656519002524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519002525 Walker A motif; other site 656519002526 ATP binding site [chemical binding]; other site 656519002527 Walker B motif; other site 656519002528 arginine finger; other site 656519002529 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 656519002530 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 656519002531 G1 box; other site 656519002532 GTP/Mg2+ binding site [chemical binding]; other site 656519002533 Switch I region; other site 656519002534 G2 box; other site 656519002535 G3 box; other site 656519002536 Switch II region; other site 656519002537 G4 box; other site 656519002538 G5 box; other site 656519002539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 656519002540 S-adenosylmethionine binding site [chemical binding]; other site 656519002541 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 656519002542 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519002543 ApbE family; Region: ApbE; cl00643 656519002544 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 656519002545 substrate binding pocket [chemical binding]; other site 656519002546 chain length determination region; other site 656519002547 substrate-Mg2+ binding site; other site 656519002548 catalytic residues [active] 656519002549 aspartate-rich region 1; other site 656519002550 active site lid residues [active] 656519002551 aspartate-rich region 2; other site 656519002552 peroxiredoxin; Provisional; Region: PRK13189 656519002553 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 656519002554 dimer interface [polypeptide binding]; other site 656519002555 decamer (pentamer of dimers) interface [polypeptide binding]; other site 656519002556 catalytic triad [active] 656519002557 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 656519002558 autolysin; Reviewed; Region: PRK06347 656519002559 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 656519002560 putative peptidoglycan binding site; other site 656519002561 Histidine kinase; Region: His_kinase; pfam06580 656519002562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656519002563 ATP binding site [chemical binding]; other site 656519002564 Mg2+ binding site [ion binding]; other site 656519002565 G-X-G motif; other site 656519002566 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 656519002567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 656519002568 active site 656519002569 phosphorylation site [posttranslational modification] 656519002570 intermolecular recognition site; other site 656519002571 dimerization interface [polypeptide binding]; other site 656519002572 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 656519002573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 656519002574 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 656519002575 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 656519002576 DctM-like transporters; Region: DctM; pfam06808 656519002577 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519002578 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 656519002579 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 656519002580 putative NAD(P) binding site [chemical binding]; other site 656519002581 active site 656519002582 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 656519002583 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 656519002584 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 656519002585 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 656519002586 Transcriptional regulators [Transcription]; Region: GntR; COG1802 656519002587 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656519002588 DNA-binding site [nucleotide binding]; DNA binding site 656519002589 FCD domain; Region: FCD; cl11656 656519002590 Transcriptional regulators [Transcription]; Region: GntR; COG1802 656519002591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656519002592 DNA-binding site [nucleotide binding]; DNA binding site 656519002593 FCD domain; Region: FCD; cl11656 656519002594 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 656519002595 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656519002596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519002597 dimer interface [polypeptide binding]; other site 656519002598 conserved gate region; other site 656519002599 putative PBP binding loops; other site 656519002600 ABC-ATPase subunit interface; other site 656519002601 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 656519002602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519002603 dimer interface [polypeptide binding]; other site 656519002604 conserved gate region; other site 656519002605 putative PBP binding loops; other site 656519002606 ABC-ATPase subunit interface; other site 656519002607 mannonate dehydratase; Provisional; Region: PRK03906 656519002608 mannonate dehydratase; Region: uxuA; TIGR00695 656519002609 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 656519002610 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 656519002611 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 656519002612 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 656519002613 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 656519002614 active site 656519002615 catalytic residues [active] 656519002616 altronate oxidoreductase; Provisional; Region: PRK03643 656519002617 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 656519002618 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 656519002619 Glucuronate isomerase; Region: UxaC; cl00829 656519002620 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 656519002621 galactarate dehydratase; Region: galactar-dH20; TIGR03248 656519002622 SAF domain; Region: SAF; cl00555 656519002623 SAF domain; Region: SAF; cl00555 656519002624 Membrane transport protein; Region: Mem_trans; cl09117 656519002625 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 656519002626 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 656519002627 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 656519002628 DXD motif; other site 656519002629 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 656519002630 GAF domain; Region: GAF; cl00853 656519002631 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 656519002632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519002633 Walker A motif; other site 656519002634 ATP binding site [chemical binding]; other site 656519002635 Walker B motif; other site 656519002636 arginine finger; other site 656519002637 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 656519002638 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 656519002639 tetramer interface [polypeptide binding]; other site 656519002640 TPP-binding site [chemical binding]; other site 656519002641 heterodimer interface [polypeptide binding]; other site 656519002642 phosphorylation loop region [posttranslational modification] 656519002643 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 656519002644 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 656519002645 alpha subunit interface [polypeptide binding]; other site 656519002646 TPP binding site [chemical binding]; other site 656519002647 heterodimer interface [polypeptide binding]; other site 656519002648 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 656519002649 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 656519002650 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 656519002651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 656519002652 S-adenosylmethionine binding site [chemical binding]; other site 656519002653 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 656519002654 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 656519002655 E3 interaction surface; other site 656519002656 lipoyl attachment site [posttranslational modification]; other site 656519002657 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 656519002658 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 656519002659 dimer interface [polypeptide binding]; other site 656519002660 substrate binding site [chemical binding]; other site 656519002661 metal binding site [ion binding]; metal-binding site 656519002662 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 656519002663 dimer interface [polypeptide binding]; other site 656519002664 substrate binding site [chemical binding]; other site 656519002665 metal binding site [ion binding]; metal-binding site 656519002666 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 656519002667 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 656519002668 putative NAD(P) binding site [chemical binding]; other site 656519002669 catalytic Zn binding site [ion binding]; other site 656519002670 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 656519002671 classical (c) SDRs; Region: SDR_c; cd05233 656519002672 NAD(P) binding site [chemical binding]; other site 656519002673 active site 656519002674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 656519002675 Coenzyme A binding pocket [chemical binding]; other site 656519002676 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 656519002677 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 656519002678 active site 656519002679 dimerization interface [polypeptide binding]; other site 656519002680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 656519002681 S-adenosylmethionine binding site [chemical binding]; other site 656519002682 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 656519002683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656519002684 putative substrate translocation pore; other site 656519002685 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 656519002686 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 656519002687 active site 656519002688 metal binding site [ion binding]; metal-binding site 656519002689 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 656519002690 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 656519002691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519002692 Walker A motif; other site 656519002693 ATP binding site [chemical binding]; other site 656519002694 Walker B motif; other site 656519002695 arginine finger; other site 656519002696 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 656519002697 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 656519002698 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 656519002699 active site 656519002700 Archaeal flavoproteins [Energy production and conversion]; Region: COG1036 656519002701 Flavoprotein; Region: Flavoprotein; cl08021 656519002702 dihydropteroate synthase-related protein; Region: TIGR00284 656519002703 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 656519002704 substrate binding pocket [chemical binding]; other site 656519002705 dimer interface [polypeptide binding]; other site 656519002706 inhibitor binding site; inhibition site 656519002707 Protein of unknown function (DUF447); Region: DUF447; cl01035 656519002708 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 656519002709 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 656519002710 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 656519002711 Uncharacterized protein conserved in archaea (DUF2193); Region: DUF2193; cl02034 656519002712 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 656519002713 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 656519002714 NADP binding site [chemical binding]; other site 656519002715 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 656519002716 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 656519002717 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-; Region: MopB_CT; cl09929 656519002718 molybdopterin cofactor binding site; other site 656519002719 The MopB_FmdB-FwdB CD contains the molybdenum/tungsten formylmethanofuran dehydrogenases, subunit B (FmdB/FwdB), and other related proteins. Formylmethanofuran dehydrogenase catalyzes the first step in methane formation from CO2 in methanogenic archaea...; Region: MopB_FmdB-FwdB; cd02761 656519002720 formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129 656519002721 putative [4Fe-4S] binding site [ion binding]; other site 656519002722 putative molybdopterin cofactor binding site [chemical binding]; other site 656519002723 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 656519002724 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 656519002725 active site 656519002726 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 656519002727 lobe; Region: FTR; pfam01913 656519002728 FTR, proximal lobe; Region: FTR_C; pfam02741 656519002729 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 656519002730 domain_subunit interface; other site 656519002731 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5)...; Region: MCH; cd00545 656519002732 trimer interface I [polypeptide binding]; other site 656519002733 putative substrate binding pocket [chemical binding]; other site 656519002734 trimer interface II [polypeptide binding]; other site 656519002735 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 656519002736 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 656519002737 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 656519002738 Uncharacterized ACR, COG1469; Region: DUF198; cl00642 656519002739 Protein of unknown function (DUF556); Region: DUF556; cl00822 656519002740 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 656519002741 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 656519002742 nucleotide binding site [chemical binding]; other site 656519002743 substrate binding site [chemical binding]; other site 656519002744 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 656519002745 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 656519002746 dihydropteroate synthase; Region: DHPS; TIGR01496 656519002747 substrate binding pocket [chemical binding]; other site 656519002748 dimer interface [polypeptide binding]; other site 656519002749 inhibitor binding site; inhibition site 656519002750 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 656519002751 homooctamer interface [polypeptide binding]; other site 656519002752 active site 656519002753 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 656519002754 catalytic center binding site [active] 656519002755 ATP binding site [chemical binding]; other site 656519002756 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 656519002757 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 656519002758 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 656519002759 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 656519002760 homodimer interface [polypeptide binding]; other site 656519002761 substrate-cofactor binding pocket; other site 656519002762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519002763 catalytic residue [active] 656519002764 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 656519002765 proposed active site lysine [active] 656519002766 conserved cys residue [active] 656519002767 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 656519002768 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 656519002769 Haemolysin-III related; Region: HlyIII; cl03831 656519002770 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 656519002771 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 656519002772 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 656519002773 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 656519002774 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 656519002775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519002776 dimer interface [polypeptide binding]; other site 656519002777 conserved gate region; other site 656519002778 putative PBP binding loops; other site 656519002779 ABC-ATPase subunit interface; other site 656519002780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519002781 dimer interface [polypeptide binding]; other site 656519002782 conserved gate region; other site 656519002783 putative PBP binding loops; other site 656519002784 ABC-ATPase subunit interface; other site 656519002785 Predicted transcriptional regulator [Transcription]; Region: COG2378 656519002786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519002787 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 656519002788 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 656519002789 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 656519002790 active site 656519002791 substrate binding site [chemical binding]; other site 656519002792 metal binding site [ion binding]; metal-binding site 656519002793 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 656519002794 FMN binding site [chemical binding]; other site 656519002795 dimer interface [polypeptide binding]; other site 656519002796 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 656519002797 dimer interface [polypeptide binding]; other site 656519002798 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 656519002799 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 656519002800 active site 656519002801 catalytic tetrad [active] 656519002802 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 656519002803 putative lipid kinase; Reviewed; Region: PRK13059 656519002804 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 656519002805 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 656519002806 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656519002807 Uncharacterised BCR, COG1649; Region: DUF187; pfam02638 656519002808 YKOF-related Family; Region: Ykof; pfam07615 656519002809 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 656519002810 active site 656519002811 putative substrate binding region [chemical binding]; other site 656519002812 FOG: CBS domain [General function prediction only]; Region: COG0517 656519002813 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC...; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 656519002814 Predicted histidine kinase sensor domain; Region: Hist_Kin_Sens; pfam10114 656519002815 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 656519002816 Histidine kinase; Region: His_kinase; pfam06580 656519002817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656519002818 ATP binding site [chemical binding]; other site 656519002819 Mg2+ binding site [ion binding]; other site 656519002820 G-X-G motif; other site 656519002821 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 656519002822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 656519002823 active site 656519002824 phosphorylation site [posttranslational modification] 656519002825 intermolecular recognition site; other site 656519002826 dimerization interface [polypeptide binding]; other site 656519002827 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 656519002828 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 656519002829 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 656519002830 Hexamer interface [polypeptide binding]; other site 656519002831 Hexagonal pore residue; other site 656519002832 propanediol utilization protein PduB; Provisional; Region: PRK15415 656519002833 Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 656519002834 putative hexamer interface [polypeptide binding]; other site 656519002835 putative hexagonal pore; other site 656519002836 Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 656519002837 putative hexamer interface [polypeptide binding]; other site 656519002838 putative hexagonal pore; other site 656519002839 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 656519002840 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1,2-...; Region: Dehydratase_LU; cl12104 656519002841 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 656519002842 alpha-beta subunit interface [polypeptide binding]; other site 656519002843 alpha-gamma subunit interface [polypeptide binding]; other site 656519002844 active site 656519002845 substrate and K+ binding site; other site 656519002846 K+ binding site [ion binding]; other site 656519002847 cobalamin binding site [chemical binding]; other site 656519002848 Dehydratase medium subunit; Region: Dehydratase_MU; cl03516 656519002849 Dehydratase small subunit; Region: Dehydratase_SU; cl02055 656519002850 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 656519002851 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 656519002852 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 656519002853 Hexamer interface [polypeptide binding]; other site 656519002854 Hexagonal pore residue; other site 656519002855 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 656519002856 Hexamer interface [polypeptide binding]; other site 656519002857 Hexagonal pore residue; other site 656519002858 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 656519002859 Flavoprotein; Region: Flavoprotein; cl08021 656519002860 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 656519002861 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 656519002862 Hexamer/Pentamer interface [polypeptide binding]; other site 656519002863 central pore; other site 656519002864 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 656519002865 Domain of unknown function (DUF336); Region: DUF336; cl01249 656519002866 aldehyde dehydrogenase EutE; Provisional; Region: PRK15398 656519002867 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 656519002868 putative catalytic cysteine [active] 656519002869 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 656519002870 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 656519002871 SLBB domain; Region: SLBB; pfam10531 656519002872 ethanolamine utilization protein, PduT homolog; Region: eut_PduT; TIGR02526 656519002873 Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 656519002874 putative hexamer interface [polypeptide binding]; other site 656519002875 putative hexagonal pore; other site 656519002876 Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 656519002877 putative hexamer interface [polypeptide binding]; other site 656519002878 putative hexagonal pore; other site 656519002879 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 656519002880 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 656519002881 active site 656519002882 NAD binding site [chemical binding]; other site 656519002883 metal binding site [ion binding]; metal-binding site 656519002884 Acetokinase family; Region: Acetate_kinase; cl01029 656519002885 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 656519002886 putative hexamer interface [polypeptide binding]; other site 656519002887 putative hexagonal pore; other site 656519002888 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 656519002889 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 656519002890 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 656519002891 Propanediol utilisation protein PduL; Region: PduL; pfam06130 656519002892 Propanediol utilisation protein PduL; Region: PduL; pfam06130 656519002893 Predicted membrane protein (DUF2177); Region: DUF2177; cl02014 656519002894 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 656519002895 dimer interface [polypeptide binding]; other site 656519002896 Domain of unknown function (DUF389); Region: DUF389; cl00781 656519002897 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 656519002898 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 656519002899 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 656519002900 FeS/SAM binding site; other site 656519002901 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 656519002902 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 656519002903 Protein of unknown function DUF89; Region: DUF89; cl00680 656519002904 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 656519002905 B12 binding site [chemical binding]; other site 656519002906 cobalt ligand [ion binding]; other site 656519002907 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 656519002908 Predicted histidine kinase sensor domain; Region: Hist_Kin_Sens; pfam10114 656519002909 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 656519002910 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 656519002911 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 656519002912 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 656519002913 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 656519002914 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine...; Region: URO-D_CIMS_like; cl00464 656519002915 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 656519002916 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 656519002917 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 656519002918 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 656519002919 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519002920 putative transposase OrfB; Reviewed; Region: PHA02517 656519002921 Integrase core domain; Region: rve; cl01316 656519002922 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656519002923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656519002924 Domain of unknown function DUF20; Region: UPF0118; cl00465 656519002925 Transposase, Mutator family; Region: Transposase_mut; pfam00872 656519002926 MULE transposase domain; Region: MULE; pfam10551 656519002927 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 656519002928 transposase; Provisional; Region: PRK06526 656519002929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519002930 Walker A motif; other site 656519002931 ATP binding site [chemical binding]; other site 656519002932 Walker B motif; other site 656519002933 Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417 656519002934 YvrJ protein family; Region: YvrJ; pfam12841 656519002935 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519002936 Integrase core domain; Region: rve; cl01316 656519002937 Uncharacterized conserved protein (DUF2081); Region: DUF2081; cl09179 656519002938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 656519002939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 656519002940 DEAD-like helicases superfamily; Region: DEXDc; smart00487 656519002941 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 656519002942 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 656519002943 UvrD/REP helicase; Region: UvrD-helicase; cl14126 656519002944 putative recombination protein RecB; Provisional; Region: PRK13909 656519002945 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 656519002946 Transposase, Mutator family; Region: Transposase_mut; pfam00872 656519002947 MULE transposase domain; Region: MULE; pfam10551 656519002948 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 656519002949 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 656519002950 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 656519002951 dimerization interface [polypeptide binding]; other site 656519002952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 656519002953 dimer interface [polypeptide binding]; other site 656519002954 phosphorylation site [posttranslational modification] 656519002955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656519002956 ATP binding site [chemical binding]; other site 656519002957 Mg2+ binding site [ion binding]; other site 656519002958 G-X-G motif; other site 656519002959 Response regulator receiver domain; Region: Response_reg; pfam00072 656519002960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 656519002961 active site 656519002962 phosphorylation site [posttranslational modification] 656519002963 intermolecular recognition site; other site 656519002964 dimerization interface [polypeptide binding]; other site 656519002965 Response regulator receiver domain; Region: Response_reg; pfam00072 656519002966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 656519002967 active site 656519002968 phosphorylation site [posttranslational modification] 656519002969 intermolecular recognition site; other site 656519002970 dimerization interface [polypeptide binding]; other site 656519002971 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 656519002972 TPR motif; other site 656519002973 binding surface 656519002974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519002975 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 656519002976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519002977 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519002978 Cation transport protein; Region: TrkH; cl10514 656519002979 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 656519002980 putative inner membrane protein; Provisional; Region: PRK11099 656519002981 YeeE/YedE family (DUF395); Region: DUF395; cl01018 656519002982 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519002983 transmembrane helices; other site 656519002984 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519002985 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519002986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 656519002987 Response regulator receiver domain; Region: Response_reg; pfam00072 656519002988 active site 656519002989 phosphorylation site [posttranslational modification] 656519002990 intermolecular recognition site; other site 656519002991 dimerization interface [polypeptide binding]; other site 656519002992 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 656519002993 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 656519002994 PAS fold; Region: PAS_3; pfam08447 656519002995 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 656519002996 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519002997 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 656519002998 metal binding site [ion binding]; metal-binding site 656519002999 active site 656519003000 I-site; other site 656519003001 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519003002 Zn2+ binding site [ion binding]; other site 656519003003 Mg2+ binding site [ion binding]; other site 656519003004 putative diguanylate cyclase; Provisional; Region: PRK09776 656519003005 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 656519003006 PAS fold; Region: PAS; pfam00989 656519003007 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519003008 putative active site [active] 656519003009 heme pocket [chemical binding]; other site 656519003010 PAS domain S-box; Region: sensory_box; TIGR00229 656519003011 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519003012 putative active site [active] 656519003013 heme pocket [chemical binding]; other site 656519003014 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519003015 metal binding site [ion binding]; metal-binding site 656519003016 active site 656519003017 I-site; other site 656519003018 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519003019 Zn2+ binding site [ion binding]; other site 656519003020 Mg2+ binding site [ion binding]; other site 656519003021 circadian clock protein KaiC; Reviewed; Region: PRK09302 656519003022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519003023 ATP binding site [chemical binding]; other site 656519003024 Walker B motif; other site 656519003025 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519003026 ATP binding site [chemical binding]; other site 656519003027 Walker B motif; other site 656519003028 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519003029 metal binding site [ion binding]; metal-binding site 656519003030 active site 656519003031 I-site; other site 656519003032 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519003033 Zn2+ binding site [ion binding]; other site 656519003034 Mg2+ binding site [ion binding]; other site 656519003035 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 656519003036 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 656519003037 ligand binding site [chemical binding]; other site 656519003038 oligomer interface [polypeptide binding]; other site 656519003039 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 656519003040 dimer interface [polypeptide binding]; other site 656519003041 N-terminal domain interface [polypeptide binding]; other site 656519003042 sulfate 1 binding site; other site 656519003043 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 656519003044 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; cl10042 656519003045 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519003046 putative transposase OrfB; Reviewed; Region: PHA02517 656519003047 Integrase core domain; Region: rve; cl01316 656519003048 beta-D-glucuronidase; Provisional; Region: PRK10150 656519003049 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 656519003050 domain; Region: Glyco_hydro_2; pfam00703 656519003051 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 656519003052 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 656519003053 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 656519003054 HD supefamily hydrolase [General function prediction only]; Region: COG3294 656519003055 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 656519003056 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 656519003057 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 656519003058 tetramer (dimer of dimers) interface [polypeptide binding]; other site 656519003059 active site 656519003060 dimer interface [polypeptide binding]; other site 656519003061 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 656519003062 C-terminal domain interface [polypeptide binding]; other site 656519003063 GSH binding site (G-site) [chemical binding]; other site 656519003064 dimer interface [polypeptide binding]; other site 656519003065 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 656519003066 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 656519003067 putative peptidoglycan binding site; other site 656519003068 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 656519003069 putative peptidoglycan binding site; other site 656519003070 Peptidase family M23; Region: Peptidase_M23; pfam01551 656519003071 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 656519003072 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 656519003073 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 656519003074 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 656519003075 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656519003076 dimerization interface [polypeptide binding]; other site 656519003077 putative DNA binding site [nucleotide binding]; other site 656519003078 putative Zn2+ binding site [ion binding]; other site 656519003079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 656519003080 S-adenosylmethionine binding site [chemical binding]; other site 656519003081 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 656519003082 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 656519003083 GTP binding site [chemical binding]; other site 656519003084 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 656519003085 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 656519003086 active site 656519003087 HIGH motif; other site 656519003088 nucleotide binding site [chemical binding]; other site 656519003089 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 656519003090 active site 656519003091 KMSKS motif; other site 656519003092 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 656519003093 tRNA binding surface [nucleotide binding]; other site 656519003094 anticodon binding site; other site 656519003095 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 656519003096 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519003097 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 656519003098 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 656519003099 dimer interface [polypeptide binding]; other site 656519003100 putative functional site; other site 656519003101 putative MPT binding site; other site 656519003102 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 656519003103 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 656519003104 dimer interface [polypeptide binding]; other site 656519003105 putative functional site; other site 656519003106 putative MPT binding site; other site 656519003107 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656519003108 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 656519003109 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 656519003110 FeS/SAM binding site; other site 656519003111 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 656519003112 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 656519003113 trimer interface [polypeptide binding]; other site 656519003114 dimer interface [polypeptide binding]; other site 656519003115 putative active site [active] 656519003116 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 656519003117 MPT binding site; other site 656519003118 trimer interface [polypeptide binding]; other site 656519003119 MOSC domain; Region: MOSC; pfam03473 656519003120 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 656519003121 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 656519003122 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 656519003123 dimer interface [polypeptide binding]; other site 656519003124 active site 656519003125 CoA binding pocket [chemical binding]; other site 656519003126 Acyl transferase domain; Region: Acyl_transf_1; cl08282 656519003127 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 656519003128 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 656519003129 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 656519003130 dimer interface [polypeptide binding]; other site 656519003131 active site 656519003132 IPP transferase; Region: IPPT; cl00403 656519003133 Protein of unknown function (DUF322); Region: DUF322; cl00574 656519003134 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 656519003135 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 656519003136 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 656519003137 EamA-like transporter family; Region: EamA; cl01037 656519003138 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 656519003139 EamA-like transporter family; Region: EamA; cl01037 656519003140 transketolase; Reviewed; Region: PRK05899 656519003141 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 656519003142 TPP-binding site [chemical binding]; other site 656519003143 dimer interface [polypeptide binding]; other site 656519003144 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 656519003145 PYR/PP interface [polypeptide binding]; other site 656519003146 dimer interface [polypeptide binding]; other site 656519003147 TPP binding site [chemical binding]; other site 656519003148 Divergent PAP2 family; Region: DUF212; cl00855 656519003149 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 656519003150 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 656519003151 Sporulation related domain; Region: SPOR; cl10051 656519003152 C subunit; Region: rnfC; TIGR01945 656519003153 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 656519003154 SLBB domain; Region: SLBB; pfam10531 656519003155 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 656519003156 RnfE family; Region: NQR2_RnfD_RnfE; cl00779 656519003157 FMN-binding domain; Region: FMN_bind; cl01081 656519003158 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 656519003159 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 656519003160 ferredoxin; Validated; Region: PRK07118 656519003161 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 656519003162 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 656519003163 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 656519003164 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 656519003165 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 656519003166 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 656519003167 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 656519003168 putative active site [active] 656519003169 putative NTP binding site [chemical binding]; other site 656519003170 putative nucleic acid binding site [nucleotide binding]; other site 656519003171 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 656519003172 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846 656519003173 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 656519003174 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 656519003175 active site 656519003176 dimer interface [polypeptide binding]; other site 656519003177 hypothetical protein; Reviewed; Region: PRK00024 656519003178 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 656519003179 MPN+ (JAMM) motif; other site 656519003180 Zinc-binding site [ion binding]; other site 656519003181 rod shape-determining protein MreB; Provisional; Region: PRK13927 656519003182 Cell division protein FtsA; Region: FtsA; cl11496 656519003183 rod shape-determining protein MreC; Region: MreC; pfam04085 656519003184 rod shape-determining protein MreD; Region: MreD; cl01087 656519003185 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 656519003186 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 656519003187 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 656519003188 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 656519003189 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 656519003190 septum site-determining protein MinD; Region: minD_bact; TIGR01968 656519003191 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 656519003192 Switch I; other site 656519003193 Switch II; other site 656519003194 Septum formation topological specificity factor MinE; Region: MinE; cl00538 656519003195 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 656519003196 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 656519003197 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 656519003198 FeS/SAM binding site; other site 656519003199 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 656519003200 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 656519003201 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 656519003202 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 656519003203 homodimer interface [polypeptide binding]; other site 656519003204 oligonucleotide binding site [chemical binding]; other site 656519003205 TRAM domain; Region: TRAM; cl01282 656519003206 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 656519003207 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 656519003208 GTPase CgtA; Reviewed; Region: obgE; PRK12297 656519003209 GTP1/OBG; Region: GTP1_OBG; pfam01018 656519003210 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 656519003211 G1 box; other site 656519003212 GTP/Mg2+ binding site [chemical binding]; other site 656519003213 Switch I region; other site 656519003214 G2 box; other site 656519003215 G3 box; other site 656519003216 Switch II region; other site 656519003217 G4 box; other site 656519003218 G5 box; other site 656519003219 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 656519003220 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 656519003221 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 656519003222 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 656519003223 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 656519003224 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 656519003225 ABC transporter; Region: ABC_tran_2; pfam12848 656519003226 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 656519003227 Nitrogen regulatory protein P-II; Region: P-II; cl00412 656519003228 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 656519003229 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 656519003230 NAD synthase; Region: NAD_synthase; pfam02540 656519003231 homodimer interface [polypeptide binding]; other site 656519003232 NAD binding pocket [chemical binding]; other site 656519003233 ATP binding pocket [chemical binding]; other site 656519003234 Mg binding site [ion binding]; other site 656519003235 active-site loop [active] 656519003236 glutamine synthetase, type I; Region: GlnA; TIGR00653 656519003237 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 656519003238 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 656519003239 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 656519003240 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 656519003241 PYR/PP interface [polypeptide binding]; other site 656519003242 dimer interface [polypeptide binding]; other site 656519003243 TPP binding site [chemical binding]; other site 656519003244 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 656519003245 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 656519003246 TPP-binding site [chemical binding]; other site 656519003247 dimer interface [polypeptide binding]; other site 656519003248 Sulfatase; Region: Sulfatase; cl10460 656519003249 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 656519003250 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 656519003251 catalytic motif [active] 656519003252 Zn binding site [ion binding]; other site 656519003253 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 656519003254 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 656519003255 Lumazine binding domain; Region: Lum_binding; pfam00677 656519003256 Lumazine binding domain; Region: Lum_binding; pfam00677 656519003257 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 656519003258 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 656519003259 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 656519003260 dimerization interface [polypeptide binding]; other site 656519003261 active site 656519003262 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 656519003263 homopentamer interface [polypeptide binding]; other site 656519003264 active site 656519003265 glycerol kinase; Provisional; Region: glpK; PRK00047 656519003266 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 656519003267 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 656519003268 Predicted dehydrogenase [General function prediction only]; Region: COG0579 656519003269 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 656519003270 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 656519003271 SelR domain; Region: SelR; cl00369 656519003272 Predicted permease [General function prediction only]; Region: COG2056 656519003273 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519003274 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 656519003275 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 656519003276 active site 656519003277 substrate binding site [chemical binding]; other site 656519003278 metal binding site [ion binding]; metal-binding site 656519003279 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 656519003280 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 656519003281 active site 656519003282 catalytic tetrad [active] 656519003283 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 656519003284 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 656519003285 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants...; Region: Thr-synth_2; cd01560 656519003286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519003287 catalytic residue [active] 656519003288 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 656519003289 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 656519003290 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 656519003291 Integrase core domain; Region: rve; cl01316 656519003292 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 656519003293 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519003294 transmembrane helices; other site 656519003295 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 656519003296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 656519003297 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 656519003298 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 656519003299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519003300 PRD domain; Region: PRD; pfam00874 656519003301 PRD domain; Region: PRD; pfam00874 656519003302 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 656519003303 P-loop; other site 656519003304 active site 656519003305 phosphorylation site [posttranslational modification] 656519003306 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 656519003307 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 656519003308 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 656519003309 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_mannitol; cd05567 656519003310 active site 656519003311 P-loop; other site 656519003312 phosphorylation site [posttranslational modification] 656519003313 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 656519003314 active site 656519003315 phosphorylation site [posttranslational modification] 656519003316 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 656519003317 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 656519003318 putative substrate binding site [chemical binding]; other site 656519003319 putative ATP binding site [chemical binding]; other site 656519003320 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 656519003321 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 656519003322 putative NAD(P) binding site [chemical binding]; other site 656519003323 catalytic Zn binding site [ion binding]; other site 656519003324 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 656519003325 dimerization domain swap beta strand [polypeptide binding]; other site 656519003326 regulatory protein interface [polypeptide binding]; other site 656519003327 active site 656519003328 regulatory phosphorylation site [posttranslational modification]; other site 656519003329 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 656519003330 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 656519003331 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 656519003332 putative ADP-ribose binding site [chemical binding]; other site 656519003333 putative active site [active] 656519003334 Putative cyclase; Region: Cyclase; cl00814 656519003335 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 656519003336 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 656519003337 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 656519003338 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 656519003339 motif II; other site 656519003340 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 656519003341 D-glutamate deacylase; Validated; Region: PRK09061 656519003342 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 656519003343 active site 656519003344 putative substrate binding pocket [chemical binding]; other site 656519003345 Predicted membrane protein [Function unknown]; Region: COG1288 656519003346 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519003347 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 656519003348 Malic enzyme, N-terminal domain; Region: malic; pfam00390 656519003349 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 656519003350 putative NAD(P) binding site [chemical binding]; other site 656519003351 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 656519003352 metal binding triad [ion binding]; metal-binding site 656519003353 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 656519003354 synthetase active site [active] 656519003355 NTP binding site [chemical binding]; other site 656519003356 metal binding site [ion binding]; metal-binding site 656519003357 homoserine dehydrogenase; Provisional; Region: PRK06349 656519003358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519003359 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 656519003360 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 656519003361 Leucine carboxyl methyltransferase; Region: LCM; cl01306 656519003362 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 656519003363 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 656519003364 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 656519003365 Acyltransferase family; Region: Acyl_transf_3; pfam01757 656519003366 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 656519003367 active site residue [active] 656519003368 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 656519003369 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein...; Region: SSP411; cd02955 656519003370 catalytic residues [active] 656519003371 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 656519003372 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 656519003373 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 656519003374 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A (...; Region: CS_ACL-C_CCL; cl00416 656519003375 Citrate synthase; Region: Citrate_synt; pfam00285 656519003376 oxalacetate binding site [chemical binding]; other site 656519003377 citrylCoA binding site [chemical binding]; other site 656519003378 coenzyme A binding site [chemical binding]; other site 656519003379 catalytic triad [active] 656519003380 short chain dehydrogenase; Provisional; Region: PRK05693 656519003381 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 656519003382 NADP binding site [chemical binding]; other site 656519003383 active site 656519003384 steroid binding site; other site 656519003385 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH...; Region: Peptidase_C1B; cd00585 656519003386 trimer interface [polypeptide binding]; other site 656519003387 active site 656519003388 G bulge; other site 656519003389 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 656519003390 dimer interface [polypeptide binding]; other site 656519003391 putative tRNA-binding site [nucleotide binding]; other site 656519003392 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 656519003393 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 656519003394 pyruvate carboxylase; Reviewed; Region: PRK12999 656519003395 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 656519003396 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 656519003397 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 656519003398 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 656519003399 active site 656519003400 catalytic residues [active] 656519003401 metal binding site [ion binding]; metal-binding site 656519003402 homodimer binding site [polypeptide binding]; other site 656519003403 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 656519003404 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 656519003405 carboxyltransferase (CT) interaction site; other site 656519003406 biotinylation site [posttranslational modification]; other site 656519003407 Chloroplast import component protein (Tic20); Region: Tic20; cl09892 656519003408 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 656519003409 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 656519003410 active site 656519003411 metal binding site [ion binding]; metal-binding site 656519003412 DNA binding site [nucleotide binding] 656519003413 Uncharacterized conserved protein [Function unknown]; Region: COG4717 656519003414 V-type ATP synthase subunit I; Validated; Region: PRK05771 656519003415 chromosome segregation protein; Provisional; Region: PRK03918 656519003416 Uncharacterized conserved protein [Function unknown]; Region: COG4717 656519003417 DNA polymerase IV; Reviewed; Region: PRK03103 656519003418 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 656519003419 active site 656519003420 DNA binding site [nucleotide binding] 656519003421 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 656519003422 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 656519003423 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 656519003424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519003425 Walker A motif; other site 656519003426 ATP binding site [chemical binding]; other site 656519003427 Walker B motif; other site 656519003428 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 656519003429 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 656519003430 ATP binding site [chemical binding]; other site 656519003431 Mg++ binding site [ion binding]; other site 656519003432 motif III; other site 656519003433 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 656519003434 nucleotide binding region [chemical binding]; other site 656519003435 ATP-binding site [chemical binding]; other site 656519003436 DbpA RNA binding domain; Region: DbpA; pfam03880 656519003437 glutamate dehydrogenase; Provisional; Region: PRK09414 656519003438 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 656519003439 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 656519003440 NAD(P) binding site [chemical binding]; other site 656519003441 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 656519003442 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 656519003443 active site 656519003444 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 656519003445 substrate binding site [chemical binding]; other site 656519003446 catalytic residues [active] 656519003447 dimer interface [polypeptide binding]; other site 656519003448 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 656519003449 dihydrodipicolinate synthase; Region: dapA; TIGR00674 656519003450 dimer interface [polypeptide binding]; other site 656519003451 active site 656519003452 catalytic residue [active] 656519003453 dihydrodipicolinate reductase; Provisional; Region: PRK00048 656519003454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519003455 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 656519003456 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapD_N; pfam08503 656519003457 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 656519003458 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350 656519003459 trimer interface [polypeptide binding]; other site 656519003460 active site 656519003461 substrate binding site [chemical binding]; other site 656519003462 CoA binding site [chemical binding]; other site 656519003463 acetylornithine aminotransferase; Provisional; Region: PRK02627 656519003464 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 656519003465 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656519003466 catalytic residue [active] 656519003467 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 656519003468 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 656519003469 DNA binding site [nucleotide binding] 656519003470 Int/Topo IB signature motif; other site 656519003471 active site 656519003472 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 656519003473 Clp amino terminal domain; Region: Clp_N; pfam02861 656519003474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519003475 Walker A motif; other site 656519003476 ATP binding site [chemical binding]; other site 656519003477 Walker B motif; other site 656519003478 arginine finger; other site 656519003479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519003480 Walker A motif; other site 656519003481 ATP binding site [chemical binding]; other site 656519003482 Walker B motif; other site 656519003483 arginine finger; other site 656519003484 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 656519003485 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 656519003486 Fic/DOC family; Region: Fic; cl00960 656519003487 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 656519003488 Fic family protein [Function unknown]; Region: COG3177 656519003489 Fic/DOC family; Region: Fic; cl00960 656519003490 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 656519003491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 656519003492 S-adenosylmethionine binding site [chemical binding]; other site 656519003493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 656519003494 S-adenosylmethionine binding site [chemical binding]; other site 656519003495 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 656519003496 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 656519003497 NAD(P) binding site [chemical binding]; other site 656519003498 putative active site [active] 656519003499 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 656519003500 Probable transposase; Region: OrfB_IS605; pfam01385 656519003501 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 656519003502 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 656519003503 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 656519003504 folate binding site [chemical binding]; other site 656519003505 NADP+ binding site [chemical binding]; other site 656519003506 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 656519003507 tryptophan synthase, beta chain; Region: PLN02618 656519003508 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 656519003509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519003510 catalytic residue [active] 656519003511 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 656519003512 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656519003513 DNA-binding site [nucleotide binding]; DNA binding site 656519003514 UTRA domain; Region: UTRA; cl06649 656519003515 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 656519003516 Chromate transporter; Region: Chromate_transp; pfam02417 656519003517 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519003518 putative transposase OrfB; Reviewed; Region: PHA02517 656519003519 Integrase core domain; Region: rve; cl01316 656519003520 Chromate transporter; Region: Chromate_transp; pfam02417 656519003521 Flavin Reductases; Region: FlaRed; cl00801 656519003522 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 656519003523 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 656519003524 catalytic residues [active] 656519003525 catalytic nucleophile [active] 656519003526 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 656519003527 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519003528 LexA repressor; Validated; Region: PRK00215 656519003529 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 656519003530 Catalytic site [active] 656519003531 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 656519003532 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 656519003533 Sm1 motif; other site 656519003534 D3 - B interaction site; other site 656519003535 D1 - D2 interaction site; other site 656519003536 Hfq - Hfq interaction site; other site 656519003537 RNA binding pocket [nucleotide binding]; other site 656519003538 Sm2 motif; other site 656519003539 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 656519003540 catalytic residues [active] 656519003541 IPP transferase; Region: IPPT; cl00403 656519003542 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 656519003543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656519003544 ATP binding site [chemical binding]; other site 656519003545 Mg2+ binding site [ion binding]; other site 656519003546 G-X-G motif; other site 656519003547 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 656519003548 ATP binding site [chemical binding]; other site 656519003549 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 656519003550 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 656519003551 MutS domain I; Region: MutS_I; pfam01624 656519003552 MutS domain II; Region: MutS_II; pfam05188 656519003553 MutS family domain IV; Region: MutS_IV; pfam05190 656519003554 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 656519003555 Walker A/P-loop; other site 656519003556 ATP binding site [chemical binding]; other site 656519003557 Q-loop/lid; other site 656519003558 ABC transporter signature motif; other site 656519003559 Walker B; other site 656519003560 D-loop; other site 656519003561 H-loop/switch region; other site 656519003562 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 656519003563 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 656519003564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 656519003565 TRAM domain; Region: TRAM; cl01282 656519003566 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 656519003567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519003568 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519003569 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 656519003570 Cation transport protein; Region: TrkH; cl10514 656519003571 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 656519003572 Rubredoxin; Region: Rubredoxin; pfam00301 656519003573 iron binding site [ion binding]; other site 656519003574 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 656519003575 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 656519003576 Cl- selectivity filter; other site 656519003577 Cl- binding residues [ion binding]; other site 656519003578 pore gating glutamate residue; other site 656519003579 dimer interface [polypeptide binding]; other site 656519003580 FOG: CBS domain [General function prediction only]; Region: COG0517 656519003581 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 656519003582 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 656519003583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656519003584 ATP binding site [chemical binding]; other site 656519003585 Mg2+ binding site [ion binding]; other site 656519003586 G-X-G motif; other site 656519003587 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 656519003588 Integrase core domain; Region: rve; cl01316 656519003589 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 656519003590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 656519003591 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 656519003592 anchoring element; other site 656519003593 dimer interface [polypeptide binding]; other site 656519003594 ATP binding site [chemical binding]; other site 656519003595 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 656519003596 active site 656519003597 putative metal-binding site [ion binding]; other site 656519003598 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 656519003599 DNA gyrase subunit A; Validated; Region: PRK05560 656519003600 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 656519003601 CAP-like domain; other site 656519003602 Active site [active] 656519003603 primary dimer interface [polypeptide binding]; other site 656519003604 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 656519003605 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 656519003606 S-layer homology domain; Region: SLH; pfam00395 656519003607 DNA repair protein RecN; Region: recN; TIGR00634 656519003608 Gram-negative bacterial tonB protein; Region: TonB; cl10048 656519003609 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 656519003610 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 656519003611 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 656519003612 dimerization interface [polypeptide binding]; other site 656519003613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 656519003614 dimer interface [polypeptide binding]; other site 656519003615 phosphorylation site [posttranslational modification] 656519003616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656519003617 ATP binding site [chemical binding]; other site 656519003618 Mg2+ binding site [ion binding]; other site 656519003619 G-X-G motif; other site 656519003620 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 656519003621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 656519003622 active site 656519003623 phosphorylation site [posttranslational modification] 656519003624 intermolecular recognition site; other site 656519003625 dimerization interface [polypeptide binding]; other site 656519003626 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 656519003627 DNA binding site [nucleotide binding] 656519003628 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 656519003629 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 656519003630 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 656519003631 putative active site [active] 656519003632 metal binding site [ion binding]; metal-binding site 656519003633 homodimer binding site [polypeptide binding]; other site 656519003634 phosphodiesterase; Provisional; Region: PRK12704 656519003635 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 656519003636 RecX family; Region: RecX; cl00936 656519003637 recombinase A; Provisional; Region: recA; PRK09354 656519003638 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 656519003639 hexamer interface [polypeptide binding]; other site 656519003640 Walker A motif; other site 656519003641 ATP binding site [chemical binding]; other site 656519003642 Walker B motif; other site 656519003643 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 656519003644 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 656519003645 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 656519003646 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 656519003647 binding surface 656519003648 TPR motif; other site 656519003649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 656519003650 binding surface 656519003651 TPR motif; other site 656519003652 competence damage-inducible protein A; Provisional; Region: PRK00549 656519003653 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 656519003654 putative MPT binding site; other site 656519003655 Competence-damaged protein; Region: CinA; cl00666 656519003656 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 656519003657 tetramer interfaces [polypeptide binding]; other site 656519003658 binuclear metal-binding site [ion binding]; other site 656519003659 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 656519003660 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 656519003661 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 656519003662 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 656519003663 FeS/SAM binding site; other site 656519003664 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 656519003665 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 656519003666 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519003667 Walker A/P-loop; other site 656519003668 ATP binding site [chemical binding]; other site 656519003669 Q-loop/lid; other site 656519003670 ABC transporter signature motif; other site 656519003671 Walker B; other site 656519003672 D-loop; other site 656519003673 H-loop/switch region; other site 656519003674 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 656519003675 The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also possess a conserved ATPase activity that...; Region: ABC_MutS_homologs; cd03243 656519003676 Walker A/P-loop; other site 656519003677 ATP binding site [chemical binding]; other site 656519003678 Q-loop/lid; other site 656519003679 ABC transporter signature motif; other site 656519003680 Walker B; other site 656519003681 D-loop; other site 656519003682 H-loop/switch region; other site 656519003683 mercuric reductase; Validated; Region: PRK06370 656519003684 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519003685 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519003686 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 656519003687 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 656519003688 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 656519003689 NAD binding site [chemical binding]; other site 656519003690 dimer interface [polypeptide binding]; other site 656519003691 substrate binding site [chemical binding]; other site 656519003692 tetramer (dimer of dimers) interface [polypeptide binding]; other site 656519003693 Uncharacterized conserved protein [Function unknown]; Region: COG2006 656519003694 Domain of unknown function (DUF362); Region: DUF362; pfam04015 656519003695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 656519003696 Survival protein SurE; Region: SurE; cl00448 656519003697 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 656519003698 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 656519003699 TM-ABC transporter signature motif; other site 656519003700 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 656519003701 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 656519003702 TM-ABC transporter signature motif; other site 656519003703 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 656519003704 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519003705 Walker A/P-loop; other site 656519003706 ATP binding site [chemical binding]; other site 656519003707 Q-loop/lid; other site 656519003708 ABC transporter signature motif; other site 656519003709 Walker B; other site 656519003710 D-loop; other site 656519003711 H-loop/switch region; other site 656519003712 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 656519003713 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 656519003714 ligand binding site [chemical binding]; other site 656519003715 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 656519003716 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519003717 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 656519003718 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 656519003719 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 656519003720 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 656519003721 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 656519003722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519003723 NAD(P) binding site [chemical binding]; other site 656519003724 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 656519003725 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 656519003726 EamA-like transporter family; Region: EamA; cl01037 656519003727 EamA-like transporter family; Region: EamA; cl01037 656519003728 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 656519003729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 656519003730 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 656519003731 Isochorismatase family; Region: Isochorismatase; pfam00857 656519003732 catalytic triad [active] 656519003733 metal binding site [ion binding]; metal-binding site 656519003734 conserved cis-peptide bond; other site 656519003735 Acylphosphatase; Region: Acylphosphatase; cl00551 656519003736 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 656519003737 GSH binding site [chemical binding]; other site 656519003738 catalytic residues [active] 656519003739 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519003740 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 656519003741 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519003742 Protein of unknown function (DUF964); Region: DUF964; cl01483 656519003743 flavoprotein, HI0933 family; Region: TIGR00275 656519003744 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519003745 aspartate aminotransferase; Provisional; Region: PRK08361 656519003746 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 656519003747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519003748 homodimer interface [polypeptide binding]; other site 656519003749 catalytic residue [active] 656519003750 dipeptidase PepV; Reviewed; Region: PRK07318 656519003751 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 656519003752 active site 656519003753 metal binding site [ion binding]; metal-binding site 656519003754 Esterase/lipase [General function prediction only]; Region: COG1647 656519003755 oligoendopeptidase F; Region: pepF; TIGR00181 656519003756 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 656519003757 active site 656519003758 Zn binding site [ion binding]; other site 656519003759 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 656519003760 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 656519003761 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 656519003762 DNA binding site [nucleotide binding] 656519003763 active site 656519003764 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 656519003765 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (...; Region: EcAsnRS_like_N; cd04318 656519003766 putative dimer interface [polypeptide binding]; other site 656519003767 putative anticodon binding site; other site 656519003768 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776 656519003769 homodimer interface [polypeptide binding]; other site 656519003770 motif 1; other site 656519003771 motif 2; other site 656519003772 active site 656519003773 motif 3; other site 656519003774 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small...; Region: DSRD; cl00018 656519003775 aspartate kinase; Reviewed; Region: PRK06635 656519003776 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 656519003777 putative nucleotide binding site [chemical binding]; other site 656519003778 putative catalytic residues [active] 656519003779 putative Mg ion binding site [ion binding]; other site 656519003780 putative aspartate binding site [chemical binding]; other site 656519003781 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 656519003782 putative allosteric regulatory site; other site 656519003783 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 656519003784 putative allosteric regulatory residue; other site 656519003785 homoserine dehydrogenase; Provisional; Region: PRK06349 656519003786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519003787 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 656519003788 homoserine kinase; Provisional; Region: PRK01212 656519003789 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 656519003790 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 656519003791 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 656519003792 trimer interface [polypeptide binding]; other site 656519003793 active site 656519003794 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 656519003795 putative peptidoglycan binding site; other site 656519003796 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 656519003797 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 656519003798 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 656519003799 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 656519003800 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 656519003801 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 656519003802 DEAD_2; Region: DEAD_2; cl14887 656519003803 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 656519003804 endonuclease IV; Provisional; Region: PRK01060 656519003805 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 656519003806 AP (apurinic/apyrimidinic) site pocket; other site 656519003807 DNA interaction; other site 656519003808 Metal-binding active site; metal-binding site 656519003809 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 656519003810 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 656519003811 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 656519003812 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 656519003813 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 656519003814 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 656519003815 putative nucleic acid binding region [nucleotide binding]; other site 656519003816 G-X-X-G motif; other site 656519003817 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 656519003818 RNA binding site [nucleotide binding]; other site 656519003819 domain interface; other site 656519003820 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 656519003821 16S/18S rRNA binding site [nucleotide binding]; other site 656519003822 S13e-L30e interaction site [polypeptide binding]; other site 656519003823 25S rRNA binding site [nucleotide binding]; other site 656519003824 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 656519003825 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 656519003826 active site 656519003827 Riboflavin kinase; Region: Flavokinase; pfam01687 656519003828 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 656519003829 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 656519003830 RNA binding site [nucleotide binding]; other site 656519003831 active site 656519003832 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 656519003833 DHH family; Region: DHH; pfam01368 656519003834 DHHA1 domain; Region: DHHA1; pfam02272 656519003835 Ribosome-binding factor A; Region: RBFA; cl00542 656519003836 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 656519003837 translation initiation factor IF-2; Region: IF-2; TIGR00487 656519003838 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 656519003839 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 656519003840 G1 box; other site 656519003841 putative GEF interaction site [polypeptide binding]; other site 656519003842 GTP/Mg2+ binding site [chemical binding]; other site 656519003843 Switch I region; other site 656519003844 G2 box; other site 656519003845 G3 box; other site 656519003846 Switch II region; other site 656519003847 G4 box; other site 656519003848 G5 box; other site 656519003849 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 656519003850 Translation-initiation factor 2; Region: IF-2; pfam11987 656519003851 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 656519003852 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 656519003853 putative RNA binding cleft [nucleotide binding]; other site 656519003854 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 656519003855 NusA N-terminal domain; Region: NusA_N; pfam08529 656519003856 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 656519003857 RNA binding site [nucleotide binding]; other site 656519003858 homodimer interface [polypeptide binding]; other site 656519003859 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 656519003860 G-X-X-G motif; other site 656519003861 ribosome maturation protein RimP; Reviewed; Region: PRK00092 656519003862 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 656519003863 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 656519003864 Sm1 motif; other site 656519003865 predicted subunit interaction site [polypeptide binding]; other site 656519003866 RNA binding pocket [nucleotide binding]; other site 656519003867 Sm2 motif; other site 656519003868 DNA polymerase III PolC; Validated; Region: polC; PRK00448 656519003869 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 656519003870 generic binding surface II; other site 656519003871 generic binding surface I; other site 656519003872 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 656519003873 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 656519003874 active site 656519003875 substrate binding site [chemical binding]; other site 656519003876 catalytic site [active] 656519003877 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 656519003878 prolyl-tRNA synthetase; Provisional; Region: PRK09194 656519003879 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 656519003880 dimer interface [polypeptide binding]; other site 656519003881 motif 1; other site 656519003882 active site 656519003883 motif 2; other site 656519003884 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 656519003885 putative deacylase active site [active] 656519003886 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 656519003887 active site 656519003888 motif 3; other site 656519003889 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 656519003890 anticodon binding site; other site 656519003891 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 656519003892 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 656519003893 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 656519003894 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 656519003895 active site 656519003896 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 656519003897 protein binding site [polypeptide binding]; other site 656519003898 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 656519003899 putative substrate binding region [chemical binding]; other site 656519003900 Domain of unknown function DUF20; Region: UPF0118; cl00465 656519003901 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 656519003902 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 656519003903 catalytic residue [active] 656519003904 putative FPP diphosphate binding site; other site 656519003905 putative FPP binding hydrophobic cleft; other site 656519003906 dimer interface [polypeptide binding]; other site 656519003907 putative IPP diphosphate binding site; other site 656519003908 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 656519003909 hinge region; other site 656519003910 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 656519003911 putative nucleotide binding site [chemical binding]; other site 656519003912 uridine monophosphate binding site [chemical binding]; other site 656519003913 homohexameric interface [polypeptide binding]; other site 656519003914 elongation factor Ts; Provisional; Region: tsf; PRK09377 656519003915 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 656519003916 Elongation factor TS; Region: EF_TS; pfam00889 656519003917 Elongation factor TS; Region: EF_TS; pfam00889 656519003918 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 656519003919 rRNA interaction site [nucleotide binding]; other site 656519003920 S8 interaction site; other site 656519003921 putative laminin-1 binding site; other site 656519003922 transcriptional repressor CodY; Validated; Region: PRK04158 656519003923 CodY GAF-like domain; Region: CodY; pfam06018 656519003924 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 656519003925 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 656519003926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519003927 Walker A motif; other site 656519003928 ATP binding site [chemical binding]; other site 656519003929 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519003930 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 656519003931 active site 656519003932 HslU subunit interaction site [polypeptide binding]; other site 656519003933 DNA topoisomerase I; Validated; Region: PRK05582 656519003934 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 656519003935 active site 656519003936 interdomain interaction site; other site 656519003937 putative metal-binding site [ion binding]; other site 656519003938 nucleotide binding site [chemical binding]; other site 656519003939 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 656519003940 domain I; other site 656519003941 DNA binding groove [nucleotide binding] 656519003942 phosphate binding site [ion binding]; other site 656519003943 domain II; other site 656519003944 domain III; other site 656519003945 nucleotide binding site [chemical binding]; other site 656519003946 catalytic site [active] 656519003947 domain IV; other site 656519003948 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 656519003949 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 656519003950 Ogr/Delta-like zinc finger; Region: Ogr_Delta; cl04623 656519003951 Protein of unknown function (DUF494); Region: DUF494; cl01103 656519003952 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 656519003953 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 656519003954 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 656519003955 Cation transport protein; Region: TrkH; cl10514 656519003956 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 656519003957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519003958 Protein of unknown function (DUF541); Region: SIMPL; cl01077 656519003959 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 656519003960 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 656519003961 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 656519003962 Gram-negative bacterial tonB protein; Region: TonB; cl10048 656519003963 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 656519003964 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 656519003965 N-terminal plug; other site 656519003966 ligand-binding site [chemical binding]; other site 656519003967 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 656519003968 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 656519003969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519003970 Walker A motif; other site 656519003971 ATP binding site [chemical binding]; other site 656519003972 Walker B motif; other site 656519003973 arginine finger; other site 656519003974 QueT transporter; Region: QueT; cl01932 656519003975 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 656519003976 RNA/DNA hybrid binding site [nucleotide binding]; other site 656519003977 active site 656519003978 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 656519003979 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856 656519003980 GTP/Mg2+ binding site [chemical binding]; other site 656519003981 G4 box; other site 656519003982 G5 box; other site 656519003983 G1 box; other site 656519003984 Switch I region; other site 656519003985 G2 box; other site 656519003986 G3 box; other site 656519003987 Switch II region; other site 656519003988 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 656519003989 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 656519003990 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 656519003991 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 656519003992 RimM N-terminal domain; Region: RimM; pfam01782 656519003993 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 656519003994 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 656519003995 signal recognition particle protein; Provisional; Region: PRK10867 656519003996 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 656519003997 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 656519003998 P loop; other site 656519003999 GTP binding site [chemical binding]; other site 656519004000 Signal peptide binding domain; Region: SRP_SPB; pfam02978 656519004001 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 656519004002 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 656519004003 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 656519004004 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 656519004005 P loop; other site 656519004006 GTP binding site [chemical binding]; other site 656519004007 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 656519004008 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 656519004009 Walker A/P-loop; other site 656519004010 ATP binding site [chemical binding]; other site 656519004011 Q-loop/lid; other site 656519004012 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 656519004013 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 656519004014 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 656519004015 Walker B; other site 656519004016 D-loop; other site 656519004017 H-loop/switch region; other site 656519004018 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 656519004019 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 656519004020 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 656519004021 RNA binding surface [nucleotide binding]; other site 656519004022 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 656519004023 active site 656519004024 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 656519004025 ScpA/B protein; Region: ScpA_ScpB; cl00598 656519004026 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 656519004027 putative substrate binding region [chemical binding]; other site 656519004028 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 656519004029 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 656519004030 active site 656519004031 NTP binding site [chemical binding]; other site 656519004032 metal binding triad [ion binding]; metal-binding site 656519004033 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 656519004034 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl12019 656519004035 active site 656519004036 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 656519004037 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 656519004038 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 656519004039 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 656519004040 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 656519004041 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 656519004042 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 656519004043 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 656519004044 dimer interface [polypeptide binding]; other site 656519004045 ADP-ribose binding site [chemical binding]; other site 656519004046 active site 656519004047 nudix motif; other site 656519004048 metal binding site [ion binding]; metal-binding site 656519004049 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 656519004050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 656519004051 active site 656519004052 phosphorylation site [posttranslational modification] 656519004053 intermolecular recognition site; other site 656519004054 dimerization interface [polypeptide binding]; other site 656519004055 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 656519004056 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 656519004057 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 656519004058 Walker A/P-loop; other site 656519004059 ATP binding site [chemical binding]; other site 656519004060 Q-loop/lid; other site 656519004061 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 656519004062 ABC transporter signature motif; other site 656519004063 Walker B; other site 656519004064 D-loop; other site 656519004065 H-loop/switch region; other site 656519004066 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 656519004067 ATP-NAD kinase; Region: NAD_kinase; pfam01513 656519004068 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 656519004069 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 656519004070 RNA binding surface [nucleotide binding]; other site 656519004071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 656519004072 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 656519004073 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 656519004074 TPP-binding site; other site 656519004075 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 656519004076 PYR/PP interface [polypeptide binding]; other site 656519004077 dimer interface [polypeptide binding]; other site 656519004078 TPP binding site [chemical binding]; other site 656519004079 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 656519004080 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 656519004081 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 656519004082 substrate binding pocket [chemical binding]; other site 656519004083 chain length determination region; other site 656519004084 substrate-Mg2+ binding site; other site 656519004085 catalytic residues [active] 656519004086 aspartate-rich region 1; other site 656519004087 active site lid residues [active] 656519004088 aspartate-rich region 2; other site 656519004089 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 656519004090 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 656519004091 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 656519004092 generic binding surface II; other site 656519004093 generic binding surface I; other site 656519004094 putative oxidoreductase; Provisional; Region: PRK12831 656519004095 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 656519004096 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519004097 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 656519004098 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-...; Region: DHOD_e_trans_like1; cd06219 656519004099 FAD binding pocket [chemical binding]; other site 656519004100 FAD binding motif [chemical binding]; other site 656519004101 phosphate binding motif [ion binding]; other site 656519004102 beta-alpha-beta structure motif; other site 656519004103 NAD binding pocket [chemical binding]; other site 656519004104 Iron coordination center [ion binding]; other site 656519004105 aspartate aminotransferase; Provisional; Region: PRK08361 656519004106 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 656519004107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519004108 homodimer interface [polypeptide binding]; other site 656519004109 catalytic residue [active] 656519004110 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 656519004111 putative RNA binding site [nucleotide binding]; other site 656519004112 Protein of unknown function (DUF322); Region: DUF322; cl00574 656519004113 Protein of unknown function (DUF322); Region: DUF322; cl00574 656519004114 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 656519004115 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519004116 elongation factor P; Validated; Region: PRK00529 656519004117 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 656519004118 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 656519004119 RNA binding site [nucleotide binding]; other site 656519004120 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 656519004121 RNA binding site [nucleotide binding]; other site 656519004122 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 656519004123 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 656519004124 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 656519004125 active site 656519004126 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 656519004127 trimer interface [polypeptide binding]; other site 656519004128 active site 656519004129 dimer interface [polypeptide binding]; other site 656519004130 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 656519004131 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 656519004132 ADP binding site [chemical binding]; other site 656519004133 magnesium binding site [ion binding]; other site 656519004134 putative shikimate binding site; other site 656519004135 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 656519004136 active site 656519004137 dimer interface [polypeptide binding]; other site 656519004138 metal binding site [ion binding]; metal-binding site 656519004139 O-Antigen ligase; Region: Wzy_C; cl04850 656519004140 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 656519004141 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 656519004142 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 656519004143 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 656519004144 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 656519004145 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 656519004146 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 656519004147 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 656519004148 Walker A motif; other site 656519004149 ATP binding site [chemical binding]; other site 656519004150 Walker B motif; other site 656519004151 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 656519004152 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 656519004153 active site 656519004154 catalytic residues [active] 656519004155 metal binding site [ion binding]; metal-binding site 656519004156 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 656519004157 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 656519004158 isocitrate dehydrogenase; Validated; Region: PRK06451 656519004159 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 656519004160 substrate binding site [chemical binding]; other site 656519004161 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 656519004162 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 656519004163 substrate binding site [chemical binding]; other site 656519004164 ligand binding site [chemical binding]; other site 656519004165 2-isopropylmalate synthase; Validated; Region: PRK00915 656519004166 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 656519004167 active site 656519004168 catalytic residues [active] 656519004169 metal binding site [ion binding]; metal-binding site 656519004170 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 656519004171 ketol-acid reductoisomerase; Provisional; Region: PRK05479 656519004172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519004173 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 656519004174 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 656519004175 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 656519004176 putative valine binding site [chemical binding]; other site 656519004177 dimer interface [polypeptide binding]; other site 656519004178 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 656519004179 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 656519004180 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 656519004181 PYR/PP interface [polypeptide binding]; other site 656519004182 dimer interface [polypeptide binding]; other site 656519004183 TPP binding site [chemical binding]; other site 656519004184 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 656519004185 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 656519004186 TPP-binding site [chemical binding]; other site 656519004187 dimer interface [polypeptide binding]; other site 656519004188 Dehydratase family; Region: ILVD_EDD; cl00340 656519004189 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 656519004190 branched-chain amino acid aminotransferase; Provisional; Region: PRK12479 656519004191 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-...; Region: D-AAT_like; cd01558 656519004192 homodimer interface [polypeptide binding]; other site 656519004193 substrate-cofactor binding pocket; other site 656519004194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519004195 catalytic residue [active] 656519004196 Transposase domain (DUF772); Region: DUF772; cl12084 656519004197 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 656519004198 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 656519004199 DNA binding residues [nucleotide binding] 656519004200 dimerization interface [polypeptide binding]; other site 656519004201 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 656519004202 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 656519004203 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 656519004204 Pilus assembly protein, PilO; Region: PilO; cl01234 656519004205 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 656519004206 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 656519004207 Competence protein A; Region: Competence_A; pfam11104 656519004208 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 656519004209 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 656519004210 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 656519004211 general secretion pathway protein F; Region: GspF; TIGR02120 656519004212 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 656519004213 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 656519004214 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 656519004215 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519004216 Walker A motif; other site 656519004217 ATP binding site [chemical binding]; other site 656519004218 Walker B motif; other site 656519004219 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 656519004220 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 656519004221 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 656519004222 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 656519004223 Walker A motif; other site 656519004224 ATP binding site [chemical binding]; other site 656519004225 Walker B motif; other site 656519004226 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 656519004227 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 656519004228 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 656519004229 shikimate binding site; other site 656519004230 NAD(P) binding site [chemical binding]; other site 656519004231 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 656519004232 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 656519004233 ligand binding site [chemical binding]; other site 656519004234 flexible hinge region; other site 656519004235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519004236 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 656519004237 metal binding site 2 [ion binding]; metal-binding site 656519004238 putative DNA binding helix; other site 656519004239 metal binding site 1 [ion binding]; metal-binding site 656519004240 dimer interface [polypeptide binding]; other site 656519004241 structural Zn2+ binding site [ion binding]; other site 656519004242 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 656519004243 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 656519004244 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 656519004245 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 656519004246 putative protease; Provisional; Region: PRK15452 656519004247 Peptidase family U32; Region: Peptidase_U32; cl03113 656519004248 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 656519004249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 656519004250 S-adenosylmethionine binding site [chemical binding]; other site 656519004251 YceG-like family; Region: YceG; pfam02618 656519004252 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 656519004253 dimerization interface [polypeptide binding]; other site 656519004254 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 656519004255 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 656519004256 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 656519004257 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 656519004258 motif 1; other site 656519004259 active site 656519004260 motif 2; other site 656519004261 motif 3; other site 656519004262 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 656519004263 DHHA1 domain; Region: DHHA1; pfam02272 656519004264 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 656519004265 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 656519004266 active site 656519004267 HIGH motif; other site 656519004268 dimer interface [polypeptide binding]; other site 656519004269 KMSKS motif; other site 656519004270 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 656519004271 Transglycosylase; Region: Transgly; cl07896 656519004272 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 656519004273 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 656519004274 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 656519004275 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 656519004276 Walker A/P-loop; other site 656519004277 ATP binding site [chemical binding]; other site 656519004278 Q-loop/lid; other site 656519004279 ABC transporter signature motif; other site 656519004280 Walker B; other site 656519004281 D-loop; other site 656519004282 H-loop/switch region; other site 656519004283 Smr domain; Region: Smr; cl02619 656519004284 hypothetical protein; Provisional; Region: PRK08609 656519004285 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 656519004286 active site 656519004287 primer binding site [nucleotide binding]; other site 656519004288 NTP binding site [chemical binding]; other site 656519004289 metal binding triad [ion binding]; metal-binding site 656519004290 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 656519004291 Colicin V production protein; Region: Colicin_V; cl00567 656519004292 Cell division protein ZapA; Region: ZapA; cl01146 656519004293 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 656519004294 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 656519004295 putative tRNA-binding site [nucleotide binding]; other site 656519004296 B3/4 domain; Region: B3_4; cl11458 656519004297 tRNA synthetase B5 domain; Region: B5; cl08394 656519004298 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 656519004299 dimer interface [polypeptide binding]; other site 656519004300 motif 1; other site 656519004301 motif 3; other site 656519004302 motif 2; other site 656519004303 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 656519004304 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 656519004305 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 656519004306 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 656519004307 dimer interface [polypeptide binding]; other site 656519004308 motif 1; other site 656519004309 active site 656519004310 motif 2; other site 656519004311 motif 3; other site 656519004312 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 656519004313 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 656519004314 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 656519004315 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 656519004316 23S rRNA binding site [nucleotide binding]; other site 656519004317 L21 binding site [polypeptide binding]; other site 656519004318 L13 binding site [polypeptide binding]; other site 656519004319 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 656519004320 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 656519004321 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 656519004322 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 656519004323 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 656519004324 FMN binding site [chemical binding]; other site 656519004325 dimer interface [polypeptide binding]; other site 656519004326 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 656519004327 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 656519004328 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 656519004329 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 656519004330 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 656519004331 active site 656519004332 dimer interface [polypeptide binding]; other site 656519004333 motif 1; other site 656519004334 motif 2; other site 656519004335 motif 3; other site 656519004336 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 656519004337 anticodon binding site; other site 656519004338 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 656519004339 MgtC family; Region: MgtC; cl12207 656519004340 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 656519004341 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 656519004342 YibE/F-like protein; Region: YibE_F; cl02259 656519004343 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cd00016 656519004344 active site 656519004345 dimer interface [polypeptide binding]; other site 656519004346 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cl12039 656519004347 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 656519004348 Integrase core domain; Region: rve; cl01316 656519004349 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519004350 Integrase core domain; Region: rve; cl01316 656519004351 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 656519004352 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 656519004353 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 656519004354 YibE/F-like protein; Region: YibE_F; cl02259 656519004355 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cd00016 656519004356 active site 656519004357 dimer interface [polypeptide binding]; other site 656519004358 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cl12039 656519004359 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 656519004360 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 656519004361 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 656519004362 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 656519004363 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 656519004364 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 656519004365 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 656519004366 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 656519004367 CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718 656519004368 Predicted transcriptional regulator [Transcription]; Region: COG2378 656519004369 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 656519004370 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 656519004371 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 656519004372 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 656519004373 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 656519004374 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 656519004375 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 656519004376 putative substrate binding site [chemical binding]; other site 656519004377 putative ATP binding site [chemical binding]; other site 656519004378 4Fe-4S binding domain; Region: Fer4_5; pfam12801 656519004379 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 656519004380 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 656519004381 manganese transport transcriptional regulator; Provisional; Region: PRK03902 656519004382 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519004383 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 656519004384 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 656519004385 ABC-ATPase subunit interface; other site 656519004386 dimer interface [polypeptide binding]; other site 656519004387 putative PBP binding regions; other site 656519004388 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 656519004389 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 656519004390 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 656519004391 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 656519004392 intersubunit interface [polypeptide binding]; other site 656519004393 Chloroplast import component protein (Tic20); Region: Tic20; cl09892 656519004394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519004395 flavoprotein, HI0933 family; Region: TIGR00275 656519004396 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 656519004397 active site 656519004398 Mechanosensitive ion channel; Region: MS_channel; pfam00924 656519004399 FAD binding domain; Region: FAD_binding_4; pfam01565 656519004400 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 656519004401 Integrase core domain; Region: rve; cl01316 656519004402 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 656519004403 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 656519004404 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 656519004405 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 656519004406 Ligand binding site [chemical binding]; other site 656519004407 Uncharacterized membrane protein [Function unknown]; Region: COG3949 656519004408 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 656519004409 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 656519004410 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 656519004411 putative peptidoglycan binding site; other site 656519004412 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 656519004413 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 656519004414 putative peptidoglycan binding site; other site 656519004415 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 656519004416 Peptidase family M23; Region: Peptidase_M23; pfam01551 656519004417 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 656519004418 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 656519004419 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 656519004420 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 656519004421 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 656519004422 Stage II sporulation protein; Region: SpoIID; cl07201 656519004423 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 656519004424 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 656519004425 putative active site [active] 656519004426 PhoH-like protein; Region: PhoH; cl12134 656519004427 Domain of unknown function (DUF296); Region: DUF296; cl00720 656519004428 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 656519004429 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 656519004430 minor groove reading motif; other site 656519004431 helix-hairpin-helix signature motif; other site 656519004432 substrate binding pocket [chemical binding]; other site 656519004433 active site 656519004434 FES domain; Region: FES; smart00525 656519004435 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl01869 656519004436 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 656519004437 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 656519004438 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 656519004439 Active site [active] 656519004440 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 656519004441 Major Facilitator Superfamily; Region: MFS_1; pfam07690 656519004442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656519004443 putative substrate translocation pore; other site 656519004444 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 656519004445 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 656519004446 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 656519004447 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 656519004448 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 656519004449 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 656519004450 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 656519004451 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 656519004452 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 656519004453 active site 656519004454 putative substrate binding pocket [chemical binding]; other site 656519004455 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 656519004456 photolyase PhrII; Region: phr2; TIGR00591 656519004457 DNA photolyase; Region: DNA_photolyase; pfam00875 656519004458 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 656519004459 Mechanosensitive ion channel; Region: MS_channel; pfam00924 656519004460 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 656519004461 IHF - DNA interface [nucleotide binding]; other site 656519004462 IHF dimer interface [polypeptide binding]; other site 656519004463 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 656519004464 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519004465 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 656519004466 Domain of unknown function (DUF205); Region: DUF205; cl00410 656519004467 GTP-binding protein Der; Reviewed; Region: PRK00093 656519004468 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 656519004469 G1 box; other site 656519004470 GTP/Mg2+ binding site [chemical binding]; other site 656519004471 Switch I region; other site 656519004472 G2 box; other site 656519004473 Switch II region; other site 656519004474 G3 box; other site 656519004475 G4 box; other site 656519004476 G5 box; other site 656519004477 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 656519004478 G1 box; other site 656519004479 GTP/Mg2+ binding site [chemical binding]; other site 656519004480 Switch I region; other site 656519004481 G2 box; other site 656519004482 G3 box; other site 656519004483 Switch II region; other site 656519004484 G4 box; other site 656519004485 G5 box; other site 656519004486 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 656519004487 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 656519004488 Protein of unknown function (DUF512); Region: DUF512; pfam04459 656519004489 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 656519004490 LytB protein; Region: LYTB; cl00507 656519004491 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 656519004492 RNA binding site [nucleotide binding]; other site 656519004493 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 656519004494 RNA binding site [nucleotide binding]; other site 656519004495 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 656519004496 RNA binding site [nucleotide binding]; other site 656519004497 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 656519004498 RNA binding site [nucleotide binding]; other site 656519004499 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 656519004500 putative acyl-acceptor binding pocket; other site 656519004501 cytidylate kinase; Provisional; Region: cmk; PRK00023 656519004502 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 656519004503 CMP-binding site; other site 656519004504 The sites determining sugar specificity; other site 656519004505 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In...; Region: AroH; cd02185 656519004506 homotrimer interaction site [polypeptide binding]; other site 656519004507 active site 656519004508 ribonuclease III; Reviewed; Region: rnc; PRK00102 656519004509 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 656519004510 dimerization interface [polypeptide binding]; other site 656519004511 active site 656519004512 metal binding site [ion binding]; metal-binding site 656519004513 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 656519004514 dsRNA binding site [nucleotide binding]; other site 656519004515 Phosphopantetheine attachment site; Region: PP-binding; cl09936 656519004516 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 656519004517 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 656519004518 NAD(P) binding site [chemical binding]; other site 656519004519 homotetramer interface [polypeptide binding]; other site 656519004520 homodimer interface [polypeptide binding]; other site 656519004521 active site 656519004522 putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151 656519004523 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 656519004524 FMN binding site [chemical binding]; other site 656519004525 substrate binding site [chemical binding]; other site 656519004526 putative catalytic residue [active] 656519004527 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 656519004528 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 656519004529 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 656519004530 Acetokinase family; Region: Acetate_kinase; cl01029 656519004531 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 656519004532 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 656519004533 hypothetical protein; Provisional; Region: PRK13670 656519004534 hypothetical protein; Provisional; Region: PRK13671 656519004535 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 656519004536 protein binding site [polypeptide binding]; other site 656519004537 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 656519004538 hypothetical protein; Provisional; Region: PRK10279 656519004539 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 656519004540 nucleophile elbow; other site 656519004541 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 656519004542 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519004543 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519004544 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 656519004545 Ligand Binding Site [chemical binding]; other site 656519004546 hypothetical protein; Provisional; Region: PRK11770 656519004547 Domain of unknown function (DUF307); Region: DUF307; pfam03733 656519004548 Domain of unknown function (DUF307); Region: DUF307; pfam03733 656519004549 UbiA prenyltransferase family; Region: UbiA; cl00337 656519004550 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 656519004551 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 656519004552 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 656519004553 active site 656519004554 (T/H)XGH motif; other site 656519004555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 656519004556 S-adenosylmethionine binding site [chemical binding]; other site 656519004557 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 656519004558 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 656519004559 generic binding surface II; other site 656519004560 ssDNA binding site; other site 656519004561 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 656519004562 ATP binding site [chemical binding]; other site 656519004563 putative Mg++ binding site [ion binding]; other site 656519004564 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 656519004565 nucleotide binding region [chemical binding]; other site 656519004566 ATP-binding site [chemical binding]; other site 656519004567 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 656519004568 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 656519004569 DAK2 domain; Region: Dak2; cl03685 656519004570 Protein of unknown function (DUF322); Region: DUF322; cl00574 656519004571 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 656519004572 Thiamine pyrophosphokinase; Region: TPK; cd07995 656519004573 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 656519004574 active site 656519004575 dimerization interface [polypeptide binding]; other site 656519004576 thiamine binding site [chemical binding]; other site 656519004577 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 656519004578 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 656519004579 substrate binding site [chemical binding]; other site 656519004580 hexamer interface [polypeptide binding]; other site 656519004581 metal binding site [ion binding]; metal-binding site 656519004582 GTPase RsgA; Reviewed; Region: PRK00098 656519004583 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 656519004584 GTPase/OB domain interface [polypeptide binding]; other site 656519004585 GTPase/Zn-binding domain interface [polypeptide binding]; other site 656519004586 GTP/Mg2+ binding site [chemical binding]; other site 656519004587 G4 box; other site 656519004588 G5 box; other site 656519004589 G1 box; other site 656519004590 Switch I region; other site 656519004591 G2 box; other site 656519004592 G3 box; other site 656519004593 Switch II region; other site 656519004594 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 656519004595 active site 656519004596 ATP binding site [chemical binding]; other site 656519004597 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 656519004598 substrate binding site [chemical binding]; other site 656519004599 activation loop (A-loop); other site 656519004600 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 656519004601 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 656519004602 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 656519004603 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 656519004604 Protein phosphatase 2C; Region: PP2C; pfam00481 656519004605 Active site [active] 656519004606 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 656519004607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 656519004608 16S rRNA methyltransferase B; Provisional; Region: PRK14902 656519004609 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 656519004610 putative RNA binding site [nucleotide binding]; other site 656519004611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 656519004612 S-adenosylmethionine binding site [chemical binding]; other site 656519004613 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 656519004614 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 656519004615 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 656519004616 putative active site [active] 656519004617 substrate binding site [chemical binding]; other site 656519004618 putative cosubstrate binding site; other site 656519004619 catalytic site [active] 656519004620 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 656519004621 substrate binding site [chemical binding]; other site 656519004622 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 656519004623 active site 656519004624 catalytic residues [active] 656519004625 metal binding site [ion binding]; metal-binding site 656519004626 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 656519004627 S-adenosylmethionine synthetase; Validated; Region: PRK05250 656519004628 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 656519004629 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 656519004630 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 656519004631 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 656519004632 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 656519004633 Flavoprotein; Region: Flavoprotein; cl08021 656519004634 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 656519004635 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 656519004636 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 656519004637 catalytic site [active] 656519004638 G-X2-G-X-G-K; other site 656519004639 Domain of unknown function (DUF370); Region: DUF370; cl00898 656519004640 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 656519004641 Domain of unknown function (DUF814); Region: DUF814; pfam05670 656519004642 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 656519004643 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G_bact; cd04170 656519004644 elongation factor G; Reviewed; Region: PRK12740 656519004645 G1 box; other site 656519004646 putative GEF interaction site [polypeptide binding]; other site 656519004647 GTP/Mg2+ binding site [chemical binding]; other site 656519004648 Switch I region; other site 656519004649 G2 box; other site 656519004650 G3 box; other site 656519004651 Switch II region; other site 656519004652 G4 box; other site 656519004653 G5 box; other site 656519004654 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 656519004655 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 656519004656 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 656519004657 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 656519004658 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 656519004659 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 656519004660 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 656519004661 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 656519004662 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 656519004663 active site 656519004664 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 656519004665 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 656519004666 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 656519004667 HIGH motif; other site 656519004668 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 656519004669 active site 656519004670 KMSKS motif; other site 656519004671 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 656519004672 tRNA binding surface [nucleotide binding]; other site 656519004673 anticodon binding site; other site 656519004674 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 656519004675 DivIVA protein; Region: DivIVA; pfam05103 656519004676 DivIVA domain; Region: DivI1A_domain; TIGR03544 656519004677 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 656519004678 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 656519004679 RNA binding surface [nucleotide binding]; other site 656519004680 YGGT family; Region: YGGT; cl00508 656519004681 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 656519004682 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 656519004683 catalytic residue [active] 656519004684 HlyD family secretion protein; Region: HlyD_2; pfam12700 656519004685 putative membrane fusion protein; Region: TIGR02828 656519004686 cell division protein FtsZ; Validated; Region: PRK09330 656519004687 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 656519004688 nucleotide binding site [chemical binding]; other site 656519004689 SulA interaction site; other site 656519004690 cell division protein FtsA; Region: ftsA; TIGR01174 656519004691 Cell division protein FtsA; Region: FtsA; cl11496 656519004692 Cell division protein FtsA; Region: FtsA; cl11496 656519004693 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 656519004694 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 656519004695 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 656519004696 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 656519004697 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 656519004698 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 656519004699 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 656519004700 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 656519004701 homodimer interface [polypeptide binding]; other site 656519004702 active site 656519004703 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 656519004704 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 656519004705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519004706 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 656519004707 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 656519004708 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 656519004709 Mg++ binding site [ion binding]; other site 656519004710 putative catalytic motif [active] 656519004711 putative substrate binding site [chemical binding]; other site 656519004712 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 656519004713 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 656519004714 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 656519004715 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 656519004716 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 656519004717 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 656519004718 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 656519004719 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 656519004720 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 656519004721 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 656519004722 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 656519004723 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 656519004724 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 656519004725 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 656519004726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 656519004727 cell division protein MraZ; Reviewed; Region: PRK00326 656519004728 MraZ protein; Region: MraZ; pfam02381 656519004729 MraZ protein; Region: MraZ; pfam02381 656519004730 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 656519004731 active site 656519004732 DNA polymerase IV; Validated; Region: PRK02406 656519004733 DNA binding site [nucleotide binding] 656519004734 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 656519004735 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 656519004736 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 656519004737 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 656519004738 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 656519004739 active site 656519004740 HIGH motif; other site 656519004741 dimer interface [polypeptide binding]; other site 656519004742 KMSKS motif; other site 656519004743 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 656519004744 metal binding site 2 [ion binding]; metal-binding site 656519004745 putative DNA binding helix; other site 656519004746 metal binding site 1 [ion binding]; metal-binding site 656519004747 dimer interface [polypeptide binding]; other site 656519004748 structural Zn2+ binding site [ion binding]; other site 656519004749 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 656519004750 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 656519004751 RNA/DNA hybrid binding site [nucleotide binding]; other site 656519004752 active site 656519004753 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 656519004754 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 656519004755 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 656519004756 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 656519004757 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 656519004758 dimerization domain swap beta strand [polypeptide binding]; other site 656519004759 regulatory protein interface [polypeptide binding]; other site 656519004760 active site 656519004761 regulatory phosphorylation site [posttranslational modification]; other site 656519004762 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 656519004763 Protein of unknown function (DUF1667); Region: DUF1667; cl01591 656519004764 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 656519004765 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519004766 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 656519004767 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519004768 Predicted dehydrogenase [General function prediction only]; Region: COG0579 656519004769 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 656519004770 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 656519004771 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 656519004772 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 656519004773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519004774 dimer interface [polypeptide binding]; other site 656519004775 conserved gate region; other site 656519004776 ABC-ATPase subunit interface; other site 656519004777 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 656519004778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519004779 dimer interface [polypeptide binding]; other site 656519004780 conserved gate region; other site 656519004781 putative PBP binding loops; other site 656519004782 ABC-ATPase subunit interface; other site 656519004783 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 656519004784 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 656519004785 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 656519004786 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 656519004787 Ligand Binding Site [chemical binding]; other site 656519004788 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 656519004789 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 656519004790 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656519004791 catalytic residue [active] 656519004792 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519004793 Rrf2 family protein; Region: rrf2_super; TIGR00738 656519004794 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 656519004795 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 656519004796 recombination factor protein RarA; Reviewed; Region: PRK13342 656519004797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519004798 Walker A motif; other site 656519004799 ATP binding site [chemical binding]; other site 656519004800 Walker B motif; other site 656519004801 arginine finger; other site 656519004802 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 656519004803 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 656519004804 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 656519004805 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 656519004806 dimer interface [polypeptide binding]; other site 656519004807 anticodon binding site; other site 656519004808 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 656519004809 homodimer interface [polypeptide binding]; other site 656519004810 motif 1; other site 656519004811 active site 656519004812 motif 2; other site 656519004813 GAD domain; Region: GAD; pfam02938 656519004814 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 656519004815 motif 3; other site 656519004816 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 656519004817 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 656519004818 dimer interface [polypeptide binding]; other site 656519004819 motif 1; other site 656519004820 active site 656519004821 motif 2; other site 656519004822 motif 3; other site 656519004823 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 656519004824 anticodon binding site; other site 656519004825 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 656519004826 TPR motif; other site 656519004827 binding surface 656519004828 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 656519004829 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 656519004830 putative active site [active] 656519004831 dimerization interface [polypeptide binding]; other site 656519004832 putative tRNAtyr binding site [nucleotide binding]; other site 656519004833 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 656519004834 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 656519004835 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 656519004836 synthetase active site [active] 656519004837 NTP binding site [chemical binding]; other site 656519004838 metal binding site [ion binding]; metal-binding site 656519004839 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 656519004840 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 656519004841 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 656519004842 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 656519004843 DHH family; Region: DHH; pfam01368 656519004844 DHHA1 domain; Region: DHHA1; pfam02272 656519004845 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 656519004846 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 656519004847 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 656519004848 Protein export membrane protein; Region: SecD_SecF; cl14618 656519004849 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 656519004850 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 656519004851 Protein export membrane protein; Region: SecD_SecF; cl14618 656519004852 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 656519004853 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 656519004854 Catalytic site [active] 656519004855 Preprotein translocase subunit; Region: YajC; cl00806 656519004856 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 656519004857 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 656519004858 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 656519004859 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 656519004860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519004861 Walker A motif; other site 656519004862 ATP binding site [chemical binding]; other site 656519004863 Walker B motif; other site 656519004864 arginine finger; other site 656519004865 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 656519004866 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 656519004867 RuvA N terminal domain; Region: RuvA_N; pfam01330 656519004868 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 656519004869 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 656519004870 active site 656519004871 putative DNA-binding cleft [nucleotide binding]; other site 656519004872 dimer interface [polypeptide binding]; other site 656519004873 Domain of unknown function DUF28; Region: DUF28; cl00361 656519004874 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 656519004875 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 656519004876 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 656519004877 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 656519004878 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 656519004879 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 656519004880 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 656519004881 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 656519004882 DNA binding residues [nucleotide binding] 656519004883 DNA primase, catalytic core; Region: dnaG; TIGR01391 656519004884 CHC2 zinc finger; Region: zf-CHC2; cl02597 656519004885 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 656519004886 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 656519004887 active site 656519004888 metal binding site [ion binding]; metal-binding site 656519004889 interdomain interaction site; other site 656519004890 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 656519004891 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519004892 Zn2+ binding site [ion binding]; other site 656519004893 Mg2+ binding site [ion binding]; other site 656519004894 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 656519004895 Domain of unknown function (DUF299); Region: DUF299; cl00780 656519004896 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 656519004897 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 656519004898 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 656519004899 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 656519004900 dimer interface [polypeptide binding]; other site 656519004901 motif 1; other site 656519004902 active site 656519004903 motif 2; other site 656519004904 motif 3; other site 656519004905 Recombination protein O N terminal; Region: RecO_N; pfam11967 656519004906 DNA repair protein RecO; Region: reco; TIGR00613 656519004907 Recombination protein O C terminal; Region: RecO_C; pfam02565 656519004908 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 656519004909 intersubunit interface [polypeptide binding]; other site 656519004910 active site 656519004911 catalytic residue [active] 656519004912 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 656519004913 MgtE intracellular N domain; Region: MgtE_N; cl15244 656519004914 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 656519004915 Divalent cation transporter; Region: MgtE; cl00786 656519004916 GTPase Era; Reviewed; Region: era; PRK00089 656519004917 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 656519004918 G1 box; other site 656519004919 GTP/Mg2+ binding site [chemical binding]; other site 656519004920 Switch I region; other site 656519004921 G2 box; other site 656519004922 Switch II region; other site 656519004923 G3 box; other site 656519004924 G4 box; other site 656519004925 G5 box; other site 656519004926 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 656519004927 active site 656519004928 catalytic motif [active] 656519004929 Zn binding site [ion binding]; other site 656519004930 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 656519004931 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 656519004932 Domain of unknown function DUF21; Region: DUF21; pfam01595 656519004933 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 656519004934 Transporter associated domain; Region: CorC_HlyC; pfam03471 656519004935 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 656519004936 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 656519004937 active site 656519004938 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 656519004939 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 656519004940 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 656519004941 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519004942 Zn2+ binding site [ion binding]; other site 656519004943 Mg2+ binding site [ion binding]; other site 656519004944 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 656519004945 PhoH-like protein; Region: PhoH; cl12134 656519004946 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 656519004947 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 656519004948 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 656519004949 dimer interface [polypeptide binding]; other site 656519004950 active site residues [active] 656519004951 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 656519004952 GatB domain; Region: GatB_Yqey; cl11497 656519004953 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 656519004954 nucleotide binding site/active site [active] 656519004955 HIT family signature motif; other site 656519004956 catalytic residue [active] 656519004957 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 656519004958 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 656519004959 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 656519004960 FeS/SAM binding site; other site 656519004961 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 656519004962 chaperone protein DnaJ; Provisional; Region: PRK10767 656519004963 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 656519004964 HSP70 interaction site [polypeptide binding]; other site 656519004965 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 656519004966 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 656519004967 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 656519004968 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 656519004969 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 656519004970 dimer interface [polypeptide binding]; other site 656519004971 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 656519004972 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 656519004973 HrcA protein C terminal domain; Region: HrcA; pfam01628 656519004974 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 656519004975 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 656519004976 FeS/SAM binding site; other site 656519004977 HemN C-terminal region; Region: HemN_C; pfam06969 656519004978 GTP-binding protein LepA; Provisional; Region: PRK05433 656519004979 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 656519004980 G1 box; other site 656519004981 putative GEF interaction site [polypeptide binding]; other site 656519004982 GTP/Mg2+ binding site [chemical binding]; other site 656519004983 Switch I region; other site 656519004984 G2 box; other site 656519004985 G3 box; other site 656519004986 Switch II region; other site 656519004987 G4 box; other site 656519004988 G5 box; other site 656519004989 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 656519004990 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 656519004991 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 656519004992 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 656519004993 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 656519004994 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 656519004995 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 656519004996 Competence protein; Region: Competence; cl00471 656519004997 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 656519004998 SLBB domain; Region: SLBB; pfam10531 656519004999 comEA protein; Region: comE; TIGR01259 656519005000 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 656519005001 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023 656519005002 ATP-binding site [chemical binding]; other site 656519005003 Sugar specificity; other site 656519005004 Pyrimidine base specificity; other site 656519005005 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 656519005006 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 656519005007 active site 656519005008 nucleophile elbow; other site 656519005009 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG1102 656519005010 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519005011 Active site [active] 656519005012 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 656519005013 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 656519005014 metal-binding site [ion binding] 656519005015 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 656519005016 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 656519005017 metal-binding site [ion binding] 656519005018 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 656519005019 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 656519005020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 656519005021 Coenzyme A binding pocket [chemical binding]; other site 656519005022 ornithine carbamoyltransferase; Validated; Region: PRK02102 656519005023 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 656519005024 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 656519005025 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 656519005026 MatE; Region: MatE; pfam01554 656519005027 MatE; Region: MatE; pfam01554 656519005028 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 656519005029 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 656519005030 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 656519005031 HIGH motif; other site 656519005032 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 656519005033 active site 656519005034 KMSKS motif; other site 656519005035 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 656519005036 tRNA binding surface [nucleotide binding]; other site 656519005037 Domain of unknown function DUF143; Region: DUF143; cl00519 656519005038 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 656519005039 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 656519005040 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 656519005041 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 656519005042 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 656519005043 active site 656519005044 (T/H)XGH motif; other site 656519005045 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 656519005046 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 656519005047 trimer interface [polypeptide binding]; other site 656519005048 putative metal binding site [ion binding]; other site 656519005049 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 656519005050 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 656519005051 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 656519005052 Pterin binding enzyme; Region: Pterin_bind; pfam00809 656519005053 substrate binding pocket [chemical binding]; other site 656519005054 dimer interface [polypeptide binding]; other site 656519005055 inhibitor binding site; inhibition site 656519005056 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 656519005057 B12 binding site [chemical binding]; other site 656519005058 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 656519005059 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 656519005060 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 656519005061 FAD binding site [chemical binding]; other site 656519005062 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 656519005063 metal-binding site [ion binding] 656519005064 Predicted membrane protein (DUF2078); Region: DUF2078; cl01373 656519005065 Predicted membrane protein (DUF2078); Region: DUF2078; cl01373 656519005066 cysteine synthases; Region: cysKM; TIGR01136 656519005067 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 656519005068 dimer interface [polypeptide binding]; other site 656519005069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519005070 catalytic residue [active] 656519005071 Rrf2 family protein; Region: rrf2_super; TIGR00738 656519005072 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519005073 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 656519005074 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 656519005075 RNA binding site [nucleotide binding]; other site 656519005076 hypothetical protein; Reviewed; Region: PRK09588 656519005077 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 656519005078 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 656519005079 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 656519005080 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 656519005081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656519005082 putative substrate translocation pore; other site 656519005083 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 656519005084 putative catalytic site [active] 656519005085 putative metal binding site [ion binding]; other site 656519005086 putative phosphate binding site [ion binding]; other site 656519005087 Sodium:solute symporter family; Region: SSF; cl00456 656519005088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 656519005089 S-adenosylmethionine binding site [chemical binding]; other site 656519005090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 656519005091 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 656519005092 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 656519005093 Transcriptional regulators [Transcription]; Region: MarR; COG1846 656519005094 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519005095 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes...; Region: NADPH_oxidoreductase_1; cd02150 656519005096 putative FMN binding site [chemical binding]; other site 656519005097 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 656519005098 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 656519005099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 656519005100 S-adenosylmethionine binding site [chemical binding]; other site 656519005101 HutP; Region: HutP; cl07944 656519005102 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984 656519005103 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 656519005104 zinc binding site [ion binding]; other site 656519005105 putative ligand binding site [chemical binding]; other site 656519005106 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 656519005107 TM-ABC transporter signature motif; other site 656519005108 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 656519005109 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519005110 Walker A/P-loop; other site 656519005111 ATP binding site [chemical binding]; other site 656519005112 Q-loop/lid; other site 656519005113 ABC transporter signature motif; other site 656519005114 Walker B; other site 656519005115 D-loop; other site 656519005116 H-loop/switch region; other site 656519005117 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 656519005118 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 656519005119 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 656519005120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519005121 dimer interface [polypeptide binding]; other site 656519005122 conserved gate region; other site 656519005123 putative PBP binding loops; other site 656519005124 ABC-ATPase subunit interface; other site 656519005125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519005126 dimer interface [polypeptide binding]; other site 656519005127 conserved gate region; other site 656519005128 putative PBP binding loops; other site 656519005129 ABC-ATPase subunit interface; other site 656519005130 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 656519005131 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656519005132 Transcriptional regulators [Transcription]; Region: PurR; COG1609 656519005133 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 656519005134 DNA binding site [nucleotide binding] 656519005135 domain linker motif; other site 656519005136 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 656519005137 dimerization interface [polypeptide binding]; other site 656519005138 ligand binding site [chemical binding]; other site 656519005139 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 656519005140 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 656519005141 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 656519005142 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 656519005143 Walker A/P-loop; other site 656519005144 ATP binding site [chemical binding]; other site 656519005145 Q-loop/lid; other site 656519005146 ABC transporter signature motif; other site 656519005147 Walker B; other site 656519005148 D-loop; other site 656519005149 H-loop/switch region; other site 656519005150 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 656519005151 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 656519005152 N-acetyl-D-glucosamine binding site [chemical binding]; other site 656519005153 catalytic residue [active] 656519005154 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 656519005155 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 656519005156 CoA-binding site [chemical binding]; other site 656519005157 ATP-binding [chemical binding]; other site 656519005158 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 656519005159 active site 656519005160 dimer interfaces [polypeptide binding]; other site 656519005161 catalytic residues [active] 656519005162 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 656519005163 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 656519005164 DNA binding site [nucleotide binding] 656519005165 catalytic residue [active] 656519005166 H2TH interface [polypeptide binding]; other site 656519005167 putative catalytic residues [active] 656519005168 turnover-facilitating residue; other site 656519005169 intercalation triad [nucleotide binding]; other site 656519005170 8OG recognition residue [nucleotide binding]; other site 656519005171 putative reading head residues; other site 656519005172 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 656519005173 DNA polymerase I; Provisional; Region: PRK05755 656519005174 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 656519005175 active site 656519005176 metal binding site 1 [ion binding]; metal-binding site 656519005177 putative 5' ssDNA interaction site; other site 656519005178 metal binding site 3; metal-binding site 656519005179 metal binding site 2 [ion binding]; metal-binding site 656519005180 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 656519005181 putative DNA binding site [nucleotide binding]; other site 656519005182 putative metal binding site [ion binding]; other site 656519005183 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 656519005184 active site 656519005185 substrate binding site [chemical binding]; other site 656519005186 catalytic site [active] 656519005187 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 656519005188 active site 656519005189 DNA binding site [nucleotide binding] 656519005190 catalytic site [active] 656519005191 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 656519005192 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 656519005193 dimerization interface [polypeptide binding]; other site 656519005194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 656519005195 dimer interface [polypeptide binding]; other site 656519005196 phosphorylation site [posttranslational modification] 656519005197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656519005198 ATP binding site [chemical binding]; other site 656519005199 Mg2+ binding site [ion binding]; other site 656519005200 G-X-G motif; other site 656519005201 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 656519005202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 656519005203 active site 656519005204 phosphorylation site [posttranslational modification] 656519005205 intermolecular recognition site; other site 656519005206 dimerization interface [polypeptide binding]; other site 656519005207 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 656519005208 DNA binding site [nucleotide binding] 656519005209 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 656519005210 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 656519005211 protein binding site [polypeptide binding]; other site 656519005212 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 656519005213 catalytic core [active] 656519005214 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 656519005215 Domain of unknown function (DUF368); Region: DUF368; cl00893 656519005216 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 656519005217 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 656519005218 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 656519005219 heterodimer interface [polypeptide binding]; other site 656519005220 active site 656519005221 FMN binding site [chemical binding]; other site 656519005222 homodimer interface [polypeptide binding]; other site 656519005223 substrate binding site [chemical binding]; other site 656519005224 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 656519005225 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 656519005226 FAD binding pocket [chemical binding]; other site 656519005227 FAD binding motif [chemical binding]; other site 656519005228 phosphate binding motif [ion binding]; other site 656519005229 beta-alpha-beta structure motif; other site 656519005230 NAD binding pocket [chemical binding]; other site 656519005231 Iron coordination center [ion binding]; other site 656519005232 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 656519005233 active site 656519005234 dimer interface [polypeptide binding]; other site 656519005235 dihydroorotase; Validated; Region: pyrC; PRK09357 656519005236 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 656519005237 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 656519005238 active site 656519005239 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 656519005240 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 656519005241 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 656519005242 Permease family; Region: Xan_ur_permease; pfam00860 656519005243 Sulfate transporter family; Region: Sulfate_transp; cl00967 656519005244 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 656519005245 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 656519005246 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 656519005247 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 656519005248 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 656519005249 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 656519005250 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 656519005251 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 656519005252 IMP binding site; other site 656519005253 dimer interface [polypeptide binding]; other site 656519005254 interdomain contacts; other site 656519005255 partial ornithine binding site; other site 656519005256 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 656519005257 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 656519005258 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 656519005259 catalytic site [active] 656519005260 subunit interface [polypeptide binding]; other site 656519005261 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 656519005262 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 656519005263 hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512 656519005264 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 656519005265 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 656519005266 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 656519005267 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 656519005268 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 656519005269 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 656519005270 putative dimer interface [polypeptide binding]; other site 656519005271 [2Fe-2S] cluster binding site [ion binding]; other site 656519005272 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 656519005273 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 656519005274 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 656519005275 ferredoxin; Provisional; Region: PRK06991 656519005276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 656519005277 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 656519005278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519005279 Walker A motif; other site 656519005280 ATP binding site [chemical binding]; other site 656519005281 Walker B motif; other site 656519005282 arginine finger; other site 656519005283 Predicted permease; Region: DUF318; cl00487 656519005284 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 656519005285 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656519005286 catalytic residue [active] 656519005287 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 656519005288 Integrase core domain; Region: rve; cl01316 656519005289 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 656519005290 DNA-binding site [nucleotide binding]; DNA binding site 656519005291 RNA-binding motif; other site 656519005292 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00197 656519005293 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 656519005294 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656519005295 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656519005296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 656519005297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519005298 dimer interface [polypeptide binding]; other site 656519005299 conserved gate region; other site 656519005300 ABC-ATPase subunit interface; other site 656519005301 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 656519005302 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 656519005303 Walker A/P-loop; other site 656519005304 ATP binding site [chemical binding]; other site 656519005305 Q-loop/lid; other site 656519005306 ABC transporter signature motif; other site 656519005307 Walker B; other site 656519005308 D-loop; other site 656519005309 H-loop/switch region; other site 656519005310 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 656519005311 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 656519005312 tetramer interfaces [polypeptide binding]; other site 656519005313 binuclear metal-binding site [ion binding]; other site 656519005314 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 656519005315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 656519005316 Coenzyme A binding pocket [chemical binding]; other site 656519005317 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cd00640 656519005318 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656519005319 catalytic residue [active] 656519005320 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519005321 putative transposase OrfB; Reviewed; Region: PHA02517 656519005322 Integrase core domain; Region: rve; cl01316 656519005323 PAS domain S-box; Region: sensory_box; TIGR00229 656519005324 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519005325 putative active site [active] 656519005326 heme pocket [chemical binding]; other site 656519005327 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519005328 metal binding site [ion binding]; metal-binding site 656519005329 active site 656519005330 I-site; other site 656519005331 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519005332 Zn2+ binding site [ion binding]; other site 656519005333 Mg2+ binding site [ion binding]; other site 656519005334 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 656519005335 Integrase core domain; Region: rve; cl01316 656519005336 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 656519005337 Integrase core domain; Region: rve; cl01316 656519005338 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 656519005339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656519005340 DNA-binding site [nucleotide binding]; DNA binding site 656519005341 Transposase, Mutator family; Region: Transposase_mut; pfam00872 656519005342 MULE transposase domain; Region: MULE; pfam10551 656519005343 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 656519005344 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 656519005345 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 656519005346 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 656519005347 homodimer interface [polypeptide binding]; other site 656519005348 NADP binding site [chemical binding]; other site 656519005349 substrate binding site [chemical binding]; other site 656519005350 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 656519005351 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 656519005352 Curli production assembly/transport component CsgF; Region: Tafi-CsgF; cl08082 656519005353 Curlin associated repeat; Region: Curlin_rpt; pfam07012 656519005354 Curlin associated repeat; Region: Curlin_rpt; pfam07012 656519005355 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 656519005356 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 656519005357 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 656519005358 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209 656519005359 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 656519005360 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 656519005361 active site 656519005362 NAD binding site [chemical binding]; other site 656519005363 metal binding site [ion binding]; metal-binding site 656519005364 Protein of unknown function (DUF436); Region: DUF436; cl01860 656519005365 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 656519005366 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 656519005367 putative hydrolase; Validated; Region: PRK09248 656519005368 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 656519005369 RNase P subunit p30; Region: RNase_P_p30; cl03389 656519005370 pyruvate kinase; Provisional; Region: PRK06354 656519005371 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 656519005372 domain interfaces; other site 656519005373 active site 656519005374 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 656519005375 6-phosphofructokinase; Provisional; Region: PRK03202 656519005376 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 656519005377 active site 656519005378 ADP/pyrophosphate binding site [chemical binding]; other site 656519005379 dimerization interface [polypeptide binding]; other site 656519005380 allosteric effector site; other site 656519005381 fructose-1,6-bisphosphate binding site; other site 656519005382 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 656519005383 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 656519005384 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 656519005385 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 656519005386 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 656519005387 generic binding surface I; other site 656519005388 generic binding surface II; other site 656519005389 NifU-like domain; Region: NifU; cl00484 656519005390 Protein of unknown function (DUF964); Region: DUF964; cl01483 656519005391 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 656519005392 active site 656519005393 metal binding site [ion binding]; metal-binding site 656519005394 homotetramer interface [polypeptide binding]; other site 656519005395 Uncharacterized conserved protein [Function unknown]; Region: COG2006 656519005396 Domain of unknown function (DUF362); Region: DUF362; pfam04015 656519005397 archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700 656519005398 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 656519005399 TRAM domain; Region: TRAM; cl01282 656519005400 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 656519005401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 656519005402 S-adenosylmethionine binding site [chemical binding]; other site 656519005403 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 656519005404 MatE; Region: MatE; pfam01554 656519005405 MatE; Region: MatE; pfam01554 656519005406 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 656519005407 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519005408 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 656519005409 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 656519005410 active site residue [active] 656519005411 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656519005412 dimerization interface [polypeptide binding]; other site 656519005413 putative DNA binding site [nucleotide binding]; other site 656519005414 putative Zn2+ binding site [ion binding]; other site 656519005415 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 656519005416 putative active site [active] 656519005417 putative CoA binding site [chemical binding]; other site 656519005418 nudix motif; other site 656519005419 metal binding site [ion binding]; metal-binding site 656519005420 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 656519005421 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 656519005422 GatB domain; Region: GatB_Yqey; cl11497 656519005423 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 656519005424 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 656519005425 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 656519005426 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 656519005427 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 656519005428 nucleotide binding pocket [chemical binding]; other site 656519005429 K-X-D-G motif; other site 656519005430 catalytic site [active] 656519005431 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 656519005432 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 656519005433 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 656519005434 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 656519005435 Dimer interface [polypeptide binding]; other site 656519005436 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 656519005437 UvrD/REP helicase; Region: UvrD-helicase; cl14126 656519005438 Domain of unknown function DUF123; Region: DUF123; cl00790 656519005439 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 656519005440 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 656519005441 G1 box; other site 656519005442 GTP/Mg2+ binding site [chemical binding]; other site 656519005443 Switch I region; other site 656519005444 G2 box; other site 656519005445 G3 box; other site 656519005446 Switch II region; other site 656519005447 G4 box; other site 656519005448 G5 box; other site 656519005449 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 656519005450 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 656519005451 dimerization interface [polypeptide binding]; other site 656519005452 domain crossover interface; other site 656519005453 redox-dependent activation switch; other site 656519005454 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 656519005455 DHH family; Region: DHH; pfam01368 656519005456 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 656519005457 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 656519005458 UvrD/REP helicase; Region: UvrD-helicase; cl14126 656519005459 UvrD/REP helicase; Region: UvrD-helicase; cl14126 656519005460 Protein of unknown function (DUF456); Region: DUF456; cl01069 656519005461 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 656519005462 dimer interface [polypeptide binding]; other site 656519005463 catalytic triad [active] 656519005464 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 656519005465 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 656519005466 Trp repressor protein; Region: Trp_repressor; cl01121 656519005467 GMP synthase; Reviewed; Region: guaA; PRK00074 656519005468 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 656519005469 AMP/PPi binding site [chemical binding]; other site 656519005470 candidate oxyanion hole; other site 656519005471 catalytic triad [active] 656519005472 potential glutamine specificity residues [chemical binding]; other site 656519005473 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 656519005474 ATP Binding subdomain [chemical binding]; other site 656519005475 Ligand Binding sites [chemical binding]; other site 656519005476 Dimerization subdomain; other site 656519005477 pyruvate phosphate dikinase; Provisional; Region: PRK09279 656519005478 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 656519005479 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 656519005480 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 656519005481 Domain of unknown function (DUF299); Region: DUF299; cl00780 656519005482 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 656519005483 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 656519005484 ring oligomerisation interface [polypeptide binding]; other site 656519005485 ATP/Mg binding site [chemical binding]; other site 656519005486 stacking interactions; other site 656519005487 hinge regions; other site 656519005488 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 656519005489 oligomerisation interface [polypeptide binding]; other site 656519005490 mobile loop; other site 656519005491 roof hairpin; other site 656519005492 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 656519005493 FeS/SAM binding site; other site 656519005494 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 656519005495 Protein of unknown function (DUF512); Region: DUF512; pfam04459 656519005496 UGMP family protein; Validated; Region: PRK09604 656519005497 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 656519005498 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 656519005499 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 656519005500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519005501 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 656519005502 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 656519005503 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 656519005504 putative catalytic cysteine [active] 656519005505 gamma-glutamyl kinase; Provisional; Region: PRK05429 656519005506 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 656519005507 nucleotide binding site [chemical binding]; other site 656519005508 homotetrameric interface [polypeptide binding]; other site 656519005509 putative phosphate binding site [ion binding]; other site 656519005510 putative allosteric binding site; other site 656519005511 PUA domain; Region: PUA; cl00607 656519005512 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 656519005513 HPr interaction site; other site 656519005514 glycerol kinase (GK) interaction site [polypeptide binding]; other site 656519005515 active site 656519005516 phosphorylation site [posttranslational modification] 656519005517 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 656519005518 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 656519005519 catalytic loop [active] 656519005520 iron binding site [ion binding]; other site 656519005521 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 656519005522 hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512 656519005523 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 656519005524 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 656519005525 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980 656519005526 dimer interface [polypeptide binding]; other site 656519005527 [2Fe-2S] cluster binding site [ion binding]; other site 656519005528 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 656519005529 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 656519005530 SLBB domain; Region: SLBB; pfam10531 656519005531 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 656519005532 4Fe-4S binding domain; Region: Fer4; cl02805 656519005533 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 656519005534 4Fe-4S binding domain; Region: Fer4; cl02805 656519005535 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980 656519005536 dimer interface [polypeptide binding]; other site 656519005537 [2Fe-2S] cluster binding site [ion binding]; other site 656519005538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656519005539 ATP binding site [chemical binding]; other site 656519005540 Mg2+ binding site [ion binding]; other site 656519005541 G-X-G motif; other site 656519005542 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 656519005543 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 656519005544 putative dimer interface [polypeptide binding]; other site 656519005545 [2Fe-2S] cluster binding site [ion binding]; other site 656519005546 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 656519005547 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 656519005548 DRTGG domain; Region: DRTGG; cl12147 656519005549 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 656519005550 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 656519005551 Putative Fe-S cluster; Region: FeS; pfam04060 656519005552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656519005553 ATP binding site [chemical binding]; other site 656519005554 Mg2+ binding site [ion binding]; other site 656519005555 G-X-G motif; other site 656519005556 PemK-like protein; Region: PemK; cl00995 656519005557 DbpA RNA binding domain; Region: DbpA; pfam03880 656519005558 DNA helicase, putative; Region: TIGR00376 656519005559 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 656519005560 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519005561 Walker A motif; other site 656519005562 ATP binding site [chemical binding]; other site 656519005563 Walker B motif; other site 656519005564 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 656519005565 trimer interface [polypeptide binding]; other site 656519005566 active site 656519005567 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 656519005568 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 656519005569 putative substrate binding site [chemical binding]; other site 656519005570 putative ATP binding site [chemical binding]; other site 656519005571 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 656519005572 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 656519005573 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 656519005574 glutaminase active site [active] 656519005575 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 656519005576 dimer interface [polypeptide binding]; other site 656519005577 active site 656519005578 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 656519005579 dimer interface [polypeptide binding]; other site 656519005580 active site 656519005581 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 656519005582 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 656519005583 active site 656519005584 substrate binding site [chemical binding]; other site 656519005585 metal binding site [ion binding]; metal-binding site 656519005586 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cl00787 656519005587 TIGR00159 family protein; Region: TIGR00159 656519005588 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 656519005589 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 656519005590 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 656519005591 FeS/SAM binding site; other site 656519005592 AMMECR1; Region: AMMECR1; cl00911 656519005593 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 656519005594 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 656519005595 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 656519005596 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 656519005597 23S rRNA interface [nucleotide binding]; other site 656519005598 L3 interface [polypeptide binding]; other site 656519005599 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 656519005600 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 656519005601 dimerization interface 3.5A [polypeptide binding]; other site 656519005602 active site 656519005603 Cobalt transport protein; Region: CbiQ; cl00463 656519005604 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 656519005605 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 656519005606 Walker A/P-loop; other site 656519005607 ATP binding site [chemical binding]; other site 656519005608 Q-loop/lid; other site 656519005609 ABC transporter signature motif; other site 656519005610 Walker B; other site 656519005611 D-loop; other site 656519005612 H-loop/switch region; other site 656519005613 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 656519005614 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 656519005615 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 656519005616 Walker A/P-loop; other site 656519005617 ATP binding site [chemical binding]; other site 656519005618 Q-loop/lid; other site 656519005619 ABC transporter signature motif; other site 656519005620 Walker B; other site 656519005621 D-loop; other site 656519005622 H-loop/switch region; other site 656519005623 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 656519005624 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 656519005625 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 656519005626 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 656519005627 alphaNTD homodimer interface [polypeptide binding]; other site 656519005628 alphaNTD - beta interaction site [polypeptide binding]; other site 656519005629 alphaNTD - beta' interaction site [polypeptide binding]; other site 656519005630 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 656519005631 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 656519005632 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 656519005633 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 656519005634 RNA binding surface [nucleotide binding]; other site 656519005635 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 656519005636 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 656519005637 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 656519005638 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 656519005639 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 656519005640 rRNA binding site [nucleotide binding]; other site 656519005641 predicted 30S ribosome binding site; other site 656519005642 methionine aminopeptidase; Reviewed; Region: PRK07281 656519005643 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 656519005644 active site 656519005645 adenylate kinase; Reviewed; Region: adk; PRK00279 656519005646 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 656519005647 AMP-binding site [chemical binding]; other site 656519005648 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 656519005649 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 656519005650 SecY translocase; Region: SecY; pfam00344 656519005651 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 656519005652 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 656519005653 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 656519005654 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 656519005655 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 656519005656 23S rRNA interface [nucleotide binding]; other site 656519005657 L21e interface [polypeptide binding]; other site 656519005658 5S rRNA interface [nucleotide binding]; other site 656519005659 L27 interface [polypeptide binding]; other site 656519005660 L5 interface [polypeptide binding]; other site 656519005661 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 656519005662 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 656519005663 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 656519005664 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 656519005665 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 656519005666 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 656519005667 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 656519005668 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 656519005669 KOW motif; Region: KOW; cl00354 656519005670 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 656519005671 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 656519005672 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 656519005673 putative translocon interaction site; other site 656519005674 23S rRNA interface [nucleotide binding]; other site 656519005675 signal recognition particle (SRP54) interaction site; other site 656519005676 L23 interface [polypeptide binding]; other site 656519005677 trigger factor interaction site; other site 656519005678 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 656519005679 23S rRNA interface [nucleotide binding]; other site 656519005680 5S rRNA interface [nucleotide binding]; other site 656519005681 putative antibiotic binding site [chemical binding]; other site 656519005682 L25 interface [polypeptide binding]; other site 656519005683 L27 interface [polypeptide binding]; other site 656519005684 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 656519005685 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 656519005686 G-X-X-G motif; other site 656519005687 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 656519005688 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 656519005689 putative translocon binding site; other site 656519005690 protein-rRNA interface [nucleotide binding]; other site 656519005691 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 656519005692 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 656519005693 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 656519005694 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 656519005695 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 656519005696 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 656519005697 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 656519005698 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 656519005699 elongation factor Tu; Reviewed; Region: PRK00049 656519005700 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 656519005701 G1 box; other site 656519005702 GEF interaction site [polypeptide binding]; other site 656519005703 GTP/Mg2+ binding site [chemical binding]; other site 656519005704 Switch I region; other site 656519005705 G2 box; other site 656519005706 G3 box; other site 656519005707 Switch II region; other site 656519005708 G4 box; other site 656519005709 G5 box; other site 656519005710 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 656519005711 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 656519005712 Antibiotic Binding Site [chemical binding]; other site 656519005713 elongation factor G; Reviewed; Region: PRK00007 656519005714 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 656519005715 G1 box; other site 656519005716 putative GEF interaction site [polypeptide binding]; other site 656519005717 GTP/Mg2+ binding site [chemical binding]; other site 656519005718 Switch I region; other site 656519005719 G2 box; other site 656519005720 G3 box; other site 656519005721 Switch II region; other site 656519005722 G4 box; other site 656519005723 G5 box; other site 656519005724 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 656519005725 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 656519005726 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 656519005727 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 656519005728 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 656519005729 S17 interaction site [polypeptide binding]; other site 656519005730 S8 interaction site; other site 656519005731 16S rRNA interaction site [nucleotide binding]; other site 656519005732 streptomycin interaction site [chemical binding]; other site 656519005733 23S rRNA interaction site [nucleotide binding]; other site 656519005734 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 656519005735 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 656519005736 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 656519005737 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 656519005738 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 656519005739 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 656519005740 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 656519005741 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 656519005742 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 656519005743 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 656519005744 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 656519005745 DNA binding site [nucleotide binding] 656519005746 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 656519005747 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 656519005748 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 656519005749 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 656519005750 RPB1 interaction site [polypeptide binding]; other site 656519005751 RPB10 interaction site [polypeptide binding]; other site 656519005752 RPB11 interaction site [polypeptide binding]; other site 656519005753 RPB3 interaction site [polypeptide binding]; other site 656519005754 RPB12 interaction site [polypeptide binding]; other site 656519005755 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 656519005756 L11 interface [polypeptide binding]; other site 656519005757 putative EF-Tu interaction site [polypeptide binding]; other site 656519005758 putative EF-G interaction site [polypeptide binding]; other site 656519005759 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 656519005760 23S rRNA interface [nucleotide binding]; other site 656519005761 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 656519005762 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 656519005763 mRNA/rRNA interface [nucleotide binding]; other site 656519005764 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 656519005765 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 656519005766 23S rRNA interface [nucleotide binding]; other site 656519005767 L7/L12 interface [polypeptide binding]; other site 656519005768 putative thiostrepton binding site; other site 656519005769 L25 interface [polypeptide binding]; other site 656519005770 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 656519005771 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 656519005772 putative homodimer interface [polypeptide binding]; other site 656519005773 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 656519005774 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 656519005775 elongation factor Tu; Reviewed; Region: PRK00049 656519005776 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 656519005777 G1 box; other site 656519005778 GEF interaction site [polypeptide binding]; other site 656519005779 GTP/Mg2+ binding site [chemical binding]; other site 656519005780 Switch I region; other site 656519005781 G2 box; other site 656519005782 G3 box; other site 656519005783 Switch II region; other site 656519005784 G4 box; other site 656519005785 G5 box; other site 656519005786 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 656519005787 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 656519005788 Antibiotic Binding Site [chemical binding]; other site 656519005789 RNA polymerase factor sigma-70; Validated; Region: PRK08295 656519005790 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 656519005791 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 656519005792 DNA binding residues [nucleotide binding] 656519005793 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 656519005794 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 656519005795 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 656519005796 Thymidylate synthase complementing protein; Region: Thy1; cl03630 656519005797 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 656519005798 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 656519005799 active site 656519005800 HIGH motif; other site 656519005801 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 656519005802 KMSKS motif; other site 656519005803 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 656519005804 tRNA binding surface [nucleotide binding]; other site 656519005805 anticodon binding site; other site 656519005806 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 656519005807 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 656519005808 active site 656519005809 HIGH motif; other site 656519005810 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 656519005811 active site 656519005812 KMSKS motif; other site 656519005813 FOG: CBS domain [General function prediction only]; Region: COG0517 656519005814 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 656519005815 HutP; Region: HutP; cl07944 656519005816 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 656519005817 homotrimer interaction site [polypeptide binding]; other site 656519005818 zinc binding site [ion binding]; other site 656519005819 CDP-binding sites; other site 656519005820 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 656519005821 substrate binding site [chemical binding]; other site 656519005822 dimer interface [polypeptide binding]; other site 656519005823 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 656519005824 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 656519005825 putative active site [active] 656519005826 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 656519005827 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 656519005828 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 656519005829 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 656519005830 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 656519005831 Clp protease ATP binding subunit; Region: clpC; CHL00095 656519005832 Clp amino terminal domain; Region: Clp_N; pfam02861 656519005833 Clp amino terminal domain; Region: Clp_N; pfam02861 656519005834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519005835 Walker A motif; other site 656519005836 ATP binding site [chemical binding]; other site 656519005837 Walker B motif; other site 656519005838 arginine finger; other site 656519005839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519005840 Walker A motif; other site 656519005841 ATP binding site [chemical binding]; other site 656519005842 Walker B motif; other site 656519005843 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 656519005844 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 656519005845 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 656519005846 ADP binding site [chemical binding]; other site 656519005847 phosphagen binding site; other site 656519005848 substrate specificity loop; other site 656519005849 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 656519005850 UvrB/uvrC motif; Region: UVR; pfam02151 656519005851 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 656519005852 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 656519005853 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 656519005854 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 656519005855 dimer interface [polypeptide binding]; other site 656519005856 putative anticodon binding site; other site 656519005857 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 656519005858 motif 1; other site 656519005859 active site 656519005860 motif 2; other site 656519005861 motif 3; other site 656519005862 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 656519005863 domain; Region: GreA_GreB_N; pfam03449 656519005864 C-term; Region: GreA_GreB; pfam01272 656519005865 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 656519005866 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 656519005867 FMN binding site [chemical binding]; other site 656519005868 active site 656519005869 catalytic residues [active] 656519005870 substrate binding site [chemical binding]; other site 656519005871 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 656519005872 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 656519005873 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 656519005874 FMN binding site [chemical binding]; other site 656519005875 substrate binding site [chemical binding]; other site 656519005876 putative catalytic residue [active] 656519005877 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 656519005878 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 656519005879 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 656519005880 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 656519005881 Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268 656519005882 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 656519005883 Potassium binding sites [ion binding]; other site 656519005884 Cesium cation binding sites [ion binding]; other site 656519005885 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 656519005886 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 656519005887 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519005888 Walker A/P-loop; other site 656519005889 ATP binding site [chemical binding]; other site 656519005890 Q-loop/lid; other site 656519005891 ABC transporter signature motif; other site 656519005892 Walker B; other site 656519005893 D-loop; other site 656519005894 H-loop/switch region; other site 656519005895 FtsH Extracellular; Region: FtsH_ext; pfam06480 656519005896 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 656519005897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519005898 Walker A motif; other site 656519005899 ATP binding site [chemical binding]; other site 656519005900 Walker B motif; other site 656519005901 arginine finger; other site 656519005902 Peptidase family M41; Region: Peptidase_M41; pfam01434 656519005903 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 656519005904 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 656519005905 Ligand Binding Site [chemical binding]; other site 656519005906 B3/4 domain; Region: B3_4; cl11458 656519005907 exopolyphosphatase; Region: exo_poly_only; TIGR03706 656519005908 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 656519005909 Protein of unknown function (DUF501); Region: DUF501; cl00652 656519005910 hypothetical protein; Provisional; Region: PRK08582 656519005911 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 656519005912 RNA binding site [nucleotide binding]; other site 656519005913 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 656519005914 Integrase core domain; Region: rve; cl01316 656519005915 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 656519005916 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 656519005917 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 656519005918 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 656519005919 RNA binding site [nucleotide binding]; other site 656519005920 Septum formation initiator; Region: DivIC; cl11433 656519005921 Protein of unknown function (DUF964); Region: DUF964; cl01483 656519005922 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 656519005923 Oxyanion-translocating ATPase (ArsA). This ATPase is involved in transport of arsenite, antimonite or other oxyanions across biological membranes in all three kingdoms of life. ArsA contains a highly conserved AAA motif present in the AAA+ ATPase...; Region: ArsA_ATPase; cd00550 656519005924 ATP binding site [chemical binding]; other site 656519005925 dimerization interface [polypeptide binding]; other site 656519005926 Metal binding site [ion binding]; metal-binding site 656519005927 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 656519005928 Oxyanion-translocating ATPase (ArsA). This ATPase is involved in transport of arsenite, antimonite or other oxyanions across biological membranes in all three kingdoms of life. ArsA contains a highly conserved AAA motif present in the AAA+ ATPase...; Region: ArsA_ATPase; cd00550 656519005929 ATP binding site [chemical binding]; other site 656519005930 dimerization interface [polypeptide binding]; other site 656519005931 Metal binding site [ion binding]; metal-binding site 656519005932 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 656519005933 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656519005934 dimerization interface [polypeptide binding]; other site 656519005935 putative DNA binding site [nucleotide binding]; other site 656519005936 putative Zn2+ binding site [ion binding]; other site 656519005937 Peptidase C26; Region: Peptidase_C26; pfam07722 656519005938 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 656519005939 catalytic triad [active] 656519005940 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 656519005941 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 656519005942 Walker A/P-loop; other site 656519005943 ATP binding site [chemical binding]; other site 656519005944 Q-loop/lid; other site 656519005945 ABC transporter signature motif; other site 656519005946 Walker B; other site 656519005947 D-loop; other site 656519005948 H-loop/switch region; other site 656519005949 TOBE domain; Region: TOBE_2; cl01440 656519005950 Transcriptional regulators [Transcription]; Region: PurR; COG1609 656519005951 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 656519005952 DNA binding site [nucleotide binding] 656519005953 domain linker motif; other site 656519005954 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 656519005955 dimerization interface [polypeptide binding]; other site 656519005956 ligand binding site [chemical binding]; other site 656519005957 beta-phosphoglucomutase; Region: bPGM; TIGR01990 656519005958 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 656519005959 motif II; other site 656519005960 hypothetical protein; Provisional; Region: PRK13679 656519005961 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 656519005962 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 656519005963 Walker A/P-loop; other site 656519005964 ATP binding site [chemical binding]; other site 656519005965 Q-loop/lid; other site 656519005966 ABC transporter signature motif; other site 656519005967 Walker B; other site 656519005968 D-loop; other site 656519005969 H-loop/switch region; other site 656519005970 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 656519005971 ABC-ATPase subunit interface; other site 656519005972 dimer interface [polypeptide binding]; other site 656519005973 putative PBP binding regions; other site 656519005974 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 656519005975 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 656519005976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519005977 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 656519005978 putative L-serine binding site [chemical binding]; other site 656519005979 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 656519005980 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656519005981 catalytic residue [active] 656519005982 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 656519005983 Beta-lactamase; Region: Beta-lactamase; cl01009 656519005984 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 656519005985 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 656519005986 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 656519005987 stage V sporulation protein B; Region: spore_V_B; TIGR02900 656519005988 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 656519005989 MatE; Region: MatE; pfam01554 656519005990 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 656519005991 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 656519005992 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 656519005993 ATP binding site [chemical binding]; other site 656519005994 putative Mg++ binding site [ion binding]; other site 656519005995 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 656519005996 nucleotide binding region [chemical binding]; other site 656519005997 ATP-binding site [chemical binding]; other site 656519005998 TRCF domain; Region: TRCF; pfam03461 656519005999 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 656519006000 putative active site [active] 656519006001 catalytic residue [active] 656519006002 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 656519006003 5S rRNA interface [nucleotide binding]; other site 656519006004 CTC domain interface; other site 656519006005 L16 interface [polypeptide binding]; other site 656519006006 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 656519006007 ribose-phosphate pyrophosphokinase; Region: ribP_PPkin; TIGR01251 656519006008 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 656519006009 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 656519006010 Substrate binding site [chemical binding]; other site 656519006011 Mg++ binding site [ion binding]; other site 656519006012 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 656519006013 active site 656519006014 substrate binding site [chemical binding]; other site 656519006015 CoA binding site [chemical binding]; other site 656519006016 SpoVG; Region: SpoVG; cl00915 656519006017 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 656519006018 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 656519006019 dimerization interface [polypeptide binding]; other site 656519006020 putative ATP binding site [chemical binding]; other site 656519006021 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 656519006022 glutamine synthetase, type I; Region: GlnA; TIGR00653 656519006023 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 656519006024 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 656519006025 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 656519006026 DNA binding residues [nucleotide binding] 656519006027 putative dimer interface [polypeptide binding]; other site 656519006028 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 656519006029 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 656519006030 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 656519006031 BioY family; Region: BioY; cl00560 656519006032 PspC domain; Region: PspC; cl00864 656519006033 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 656519006034 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 656519006035 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 656519006036 Walker A/P-loop; other site 656519006037 ATP binding site [chemical binding]; other site 656519006038 Q-loop/lid; other site 656519006039 ABC transporter signature motif; other site 656519006040 Walker B; other site 656519006041 D-loop; other site 656519006042 H-loop/switch region; other site 656519006043 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 656519006044 PhoU domain; Region: PhoU; pfam01895 656519006045 PhoU domain; Region: PhoU; pfam01895 656519006046 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 656519006047 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 656519006048 Walker A/P-loop; other site 656519006049 ATP binding site [chemical binding]; other site 656519006050 Q-loop/lid; other site 656519006051 ABC transporter signature motif; other site 656519006052 Walker B; other site 656519006053 D-loop; other site 656519006054 H-loop/switch region; other site 656519006055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519006056 dimer interface [polypeptide binding]; other site 656519006057 conserved gate region; other site 656519006058 putative PBP binding loops; other site 656519006059 ABC-ATPase subunit interface; other site 656519006060 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 656519006061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519006062 dimer interface [polypeptide binding]; other site 656519006063 conserved gate region; other site 656519006064 putative PBP binding loops; other site 656519006065 ABC-ATPase subunit interface; other site 656519006066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 656519006067 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656519006068 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 656519006069 dimerization interface [polypeptide binding]; other site 656519006070 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 656519006071 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 656519006072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 656519006073 dimer interface [polypeptide binding]; other site 656519006074 phosphorylation site [posttranslational modification] 656519006075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656519006076 ATP binding site [chemical binding]; other site 656519006077 Mg2+ binding site [ion binding]; other site 656519006078 G-X-G motif; other site 656519006079 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 656519006080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 656519006081 active site 656519006082 phosphorylation site [posttranslational modification] 656519006083 intermolecular recognition site; other site 656519006084 dimerization interface [polypeptide binding]; other site 656519006085 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 656519006086 DNA binding site [nucleotide binding] 656519006087 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 656519006088 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 656519006089 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 656519006090 PhoU domain; Region: PhoU; pfam01895 656519006091 PhoU domain; Region: PhoU; pfam01895 656519006092 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 656519006093 Protein of unknown function (DUF458); Region: DUF458; cl00861 656519006094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 656519006095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519006096 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 656519006097 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 656519006098 active site 656519006099 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 656519006100 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 656519006101 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656519006102 catalytic residue [active] 656519006103 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 656519006104 THUMP domain; Region: THUMP; cl12076 656519006105 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 656519006106 Ligand Binding Site [chemical binding]; other site 656519006107 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 656519006108 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal...; Region: PurM-like; cl10019 656519006109 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 656519006110 dimerization interface [polypeptide binding]; other site 656519006111 ATP binding site [chemical binding]; other site 656519006112 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 656519006113 dimerization interface [polypeptide binding]; other site 656519006114 ATP binding site [chemical binding]; other site 656519006115 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 656519006116 putative active site [active] 656519006117 catalytic triad [active] 656519006118 Transcriptional regulator [Transcription]; Region: LysR; COG0583 656519006119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519006120 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 656519006121 dimerization interface [polypeptide binding]; other site 656519006122 ParB-like nuclease domain; Region: ParBc; cl02129 656519006123 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 656519006124 FAD binding domain; Region: FAD_binding_4; pfam01565 656519006125 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 656519006126 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 656519006127 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 656519006128 diiron binding motif [ion binding]; other site 656519006129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656519006130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 656519006131 S-layer homology domain; Region: SLH; pfam00395 656519006132 Sulfatase; Region: Sulfatase; cl10460 656519006133 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 656519006134 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656519006135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519006136 dimer interface [polypeptide binding]; other site 656519006137 conserved gate region; other site 656519006138 ABC-ATPase subunit interface; other site 656519006139 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 656519006140 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 656519006141 Walker A/P-loop; other site 656519006142 ATP binding site [chemical binding]; other site 656519006143 Q-loop/lid; other site 656519006144 ABC transporter signature motif; other site 656519006145 Walker B; other site 656519006146 D-loop; other site 656519006147 H-loop/switch region; other site 656519006148 NIL domain; Region: NIL; pfam09383 656519006149 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 656519006150 dimerization interface [polypeptide binding]; other site 656519006151 putative DNA binding site [nucleotide binding]; other site 656519006152 putative Zn2+ binding site [ion binding]; other site 656519006153 Predicted permease; Region: DUF318; cl00487 656519006154 Predicted permease; Region: DUF318; cl00487 656519006155 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 656519006156 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 656519006157 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 656519006158 G1 box; other site 656519006159 GTP/Mg2+ binding site [chemical binding]; other site 656519006160 G2 box; other site 656519006161 Switch I region; other site 656519006162 G3 box; other site 656519006163 Switch II region; other site 656519006164 G4 box; other site 656519006165 G5 box; other site 656519006166 Nucleoside recognition; Region: Gate; cl00486 656519006167 Nucleoside recognition; Region: Gate; cl00486 656519006168 FeoA domain; Region: FeoA; cl00838 656519006169 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 656519006170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 656519006171 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 656519006172 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 656519006173 substrate binding site [chemical binding]; other site 656519006174 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 656519006175 substrate binding site [chemical binding]; other site 656519006176 ligand binding site [chemical binding]; other site 656519006177 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 656519006178 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 656519006179 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 656519006180 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 656519006181 putative active site [active] 656519006182 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 656519006183 putative homotetramer interface [polypeptide binding]; other site 656519006184 putative homodimer interface [polypeptide binding]; other site 656519006185 putative allosteric switch controlling residues; other site 656519006186 putative metal binding site [ion binding]; other site 656519006187 putative homodimer-homodimer interface [polypeptide binding]; other site 656519006188 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 656519006189 Phosphotransferase enzyme family; Region: APH; pfam01636 656519006190 active site 656519006191 substrate binding site [chemical binding]; other site 656519006192 ATP binding site [chemical binding]; other site 656519006193 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 656519006194 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 656519006195 Probable Catalytic site [active] 656519006196 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 656519006197 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 656519006198 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 656519006199 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 656519006200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519006201 dimer interface [polypeptide binding]; other site 656519006202 conserved gate region; other site 656519006203 putative PBP binding loops; other site 656519006204 ABC-ATPase subunit interface; other site 656519006205 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 656519006206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519006207 dimer interface [polypeptide binding]; other site 656519006208 conserved gate region; other site 656519006209 putative PBP binding loops; other site 656519006210 ABC-ATPase subunit interface; other site 656519006211 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 656519006212 active site 656519006213 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 656519006214 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 656519006215 active site residue [active] 656519006216 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 656519006217 active site residue [active] 656519006218 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 656519006219 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 656519006220 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 656519006221 trimerization site [polypeptide binding]; other site 656519006222 active site 656519006223 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 656519006224 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 656519006225 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656519006226 catalytic residue [active] 656519006227 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 656519006228 FeS assembly protein SufB; Region: sufB; TIGR01980 656519006229 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 656519006230 FeS assembly ATPase SufC; Region: sufC; TIGR01978 656519006231 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 656519006232 Walker A/P-loop; other site 656519006233 ATP binding site [chemical binding]; other site 656519006234 Q-loop/lid; other site 656519006235 ABC transporter signature motif; other site 656519006236 Walker B; other site 656519006237 D-loop; other site 656519006238 H-loop/switch region; other site 656519006239 Domain of unknown function DUF20; Region: UPF0118; cl00465 656519006240 subunit; Region: OAD_beta; cl00816 656519006241 pyruvate carboxylase subunit B; Validated; Region: PRK09282 656519006242 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 656519006243 carboxyltransferase (CT) interaction site; other site 656519006244 biotinylation site [posttranslational modification]; other site 656519006245 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 656519006246 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 656519006247 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 656519006248 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 656519006249 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 656519006250 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 656519006251 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519006252 Walker A/P-loop; other site 656519006253 ATP binding site [chemical binding]; other site 656519006254 Q-loop/lid; other site 656519006255 ABC transporter signature motif; other site 656519006256 Walker B; other site 656519006257 D-loop; other site 656519006258 H-loop/switch region; other site 656519006259 TOBE domain; Region: TOBE_2; cl01440 656519006260 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 656519006261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519006262 dimer interface [polypeptide binding]; other site 656519006263 conserved gate region; other site 656519006264 putative PBP binding loops; other site 656519006265 ABC-ATPase subunit interface; other site 656519006266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519006267 dimer interface [polypeptide binding]; other site 656519006268 conserved gate region; other site 656519006269 putative PBP binding loops; other site 656519006270 ABC-ATPase subunit interface; other site 656519006271 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 656519006272 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656519006273 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 656519006274 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 656519006275 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 656519006276 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 656519006277 Hexamer interface [polypeptide binding]; other site 656519006278 Hexagonal pore residue; other site 656519006279 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 656519006280 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 656519006281 putative hexamer interface [polypeptide binding]; other site 656519006282 putative hexagonal pore; other site 656519006283 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 656519006284 Hexamer interface [polypeptide binding]; other site 656519006285 Hexagonal pore residue; other site 656519006286 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 656519006287 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 656519006288 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; cl09205 656519006289 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 656519006290 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; cl09205 656519006291 Ethanolamine utilisation protein EutA; Region: EutA; pfam06277 656519006292 ethanolamine utilization protein, PduT homolog; Region: eut_PduT; TIGR02526 656519006293 Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 656519006294 putative hexamer interface [polypeptide binding]; other site 656519006295 putative hexagonal pore; other site 656519006296 Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 656519006297 putative hexamer interface [polypeptide binding]; other site 656519006298 putative hexagonal pore; other site 656519006299 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 656519006300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 656519006301 motif II; other site 656519006302 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 656519006303 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 656519006304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656519006305 sugar efflux transporter; Region: 2A0120; TIGR00899 656519006306 glycerate dehydrogenase; Provisional; Region: PRK06487 656519006307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519006308 lipoyl synthase; Provisional; Region: PRK05481 656519006309 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 656519006310 FeS/SAM binding site; other site 656519006311 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 656519006312 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 656519006313 dimer interface [polypeptide binding]; other site 656519006314 FMN binding site [chemical binding]; other site 656519006315 Uncharacterized conserved protein [Function unknown]; Region: COG2006 656519006316 Domain of unknown function (DUF362); Region: DUF362; pfam04015 656519006317 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 656519006318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519006319 homodimer interface [polypeptide binding]; other site 656519006320 catalytic residue [active] 656519006321 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 656519006322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519006323 oligomerization interface [polypeptide binding]; other site 656519006324 active site 656519006325 NAD+ binding site [chemical binding]; other site 656519006326 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 656519006327 catalytic residues [active] 656519006328 Sulfate transporter family; Region: Sulfate_transp; cl00967 656519006329 Permease family; Region: Xan_ur_permease; pfam00860 656519006330 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 656519006331 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 656519006332 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen...; Region: AdeC; cd01295 656519006333 active site 656519006334 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 656519006335 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 656519006336 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 656519006337 phosphate binding site [ion binding]; other site 656519006338 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 656519006339 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 656519006340 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519006341 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 656519006342 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 656519006343 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 656519006344 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 656519006345 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 656519006346 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 656519006347 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 656519006348 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 656519006349 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 656519006350 active site 656519006351 putative substrate binding pocket [chemical binding]; other site 656519006352 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 656519006353 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 656519006354 active site 656519006355 putative substrate binding pocket [chemical binding]; other site 656519006356 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 656519006357 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 656519006358 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 656519006359 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 656519006360 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 656519006361 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 656519006362 probable carbamoyltransferase YgeW; Region: ygeW; TIGR03316 656519006363 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 656519006364 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 656519006365 peptidase; Reviewed; Region: PRK13004 656519006366 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 656519006367 putative metal binding site [ion binding]; other site 656519006368 putative dimer interface [polypeptide binding]; other site 656519006369 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 656519006370 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 656519006371 non-specific DNA binding site [nucleotide binding]; other site 656519006372 salt bridge; other site 656519006373 sequence-specific DNA binding site [nucleotide binding]; other site 656519006374 Cupin domain; Region: Cupin_2; cl09118 656519006375 threonine synthase; Validated; Region: PRK06260 656519006376 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 656519006377 homodimer interface [polypeptide binding]; other site 656519006378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519006379 catalytic residue [active] 656519006380 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 656519006381 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656519006382 OsmC-like protein; Region: OsmC; cl00767 656519006383 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 656519006384 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 656519006385 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519006386 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 656519006387 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 656519006388 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 656519006389 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 656519006390 intersubunit interface [polypeptide binding]; other site 656519006391 active site 656519006392 Zn2+ binding site [ion binding]; other site 656519006393 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 656519006394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656519006395 Major Facilitator Superfamily; Region: MFS_1; pfam07690 656519006396 putative substrate translocation pore; other site 656519006397 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 656519006398 O-Antigen ligase; Region: Wzy_C; cl04850 656519006399 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 656519006400 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 656519006401 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 656519006402 putative metal binding site [ion binding]; other site 656519006403 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 656519006404 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 656519006405 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 656519006406 putative active site [active] 656519006407 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 656519006408 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 656519006409 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 656519006410 putative active site [active] 656519006411 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 656519006412 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 656519006413 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 656519006414 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 656519006415 putative acyl-acceptor binding pocket; other site 656519006416 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 656519006417 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 656519006418 putative active site [active] 656519006419 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 656519006420 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 656519006421 NeuB family; Region: NeuB; cl00496 656519006422 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 656519006423 Ligand binding site [chemical binding]; other site 656519006424 oligomer interface [polypeptide binding]; other site 656519006425 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 656519006426 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 656519006427 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 656519006428 putative acyl-acceptor binding pocket; other site 656519006429 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 656519006430 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 656519006431 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 656519006432 Walker A/P-loop; other site 656519006433 ATP binding site [chemical binding]; other site 656519006434 Q-loop/lid; other site 656519006435 ABC transporter signature motif; other site 656519006436 Walker B; other site 656519006437 D-loop; other site 656519006438 H-loop/switch region; other site 656519006439 HutP; Region: HutP; cl07944 656519006440 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 656519006441 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal...; Region: BtuF; cd01144 656519006442 cobalamin binding residues [chemical binding]; other site 656519006443 putative BtuC binding residues; other site 656519006444 dimer interface [polypeptide binding]; other site 656519006445 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 656519006446 homodimer interface [polypeptide binding]; other site 656519006447 NAD synthase; Region: NAD_synthase; pfam02540 656519006448 NAD binding pocket [chemical binding]; other site 656519006449 ATP binding pocket [chemical binding]; other site 656519006450 Mg binding site [ion binding]; other site 656519006451 active-site loop [active] 656519006452 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 656519006453 substrate binding site [chemical binding]; other site 656519006454 activation loop (A-loop); other site 656519006455 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 656519006456 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 656519006457 active site 656519006458 dimer interface [polypeptide binding]; other site 656519006459 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 656519006460 dimer interface [polypeptide binding]; other site 656519006461 active site 656519006462 Predicted permease; Region: DUF318; cl00487 656519006463 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 656519006464 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 656519006465 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 656519006466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519006467 dimer interface [polypeptide binding]; other site 656519006468 conserved gate region; other site 656519006469 putative PBP binding loops; other site 656519006470 ABC-ATPase subunit interface; other site 656519006471 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 656519006472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519006473 dimer interface [polypeptide binding]; other site 656519006474 conserved gate region; other site 656519006475 putative PBP binding loops; other site 656519006476 ABC-ATPase subunit interface; other site 656519006477 Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion...; Region: SORL_classII; cd03172 656519006478 non-heme iron binding site [ion binding]; other site 656519006479 tetramer interface [polypeptide binding]; other site 656519006480 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 656519006481 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 656519006482 G1 box; other site 656519006483 putative GEF interaction site [polypeptide binding]; other site 656519006484 GTP/Mg2+ binding site [chemical binding]; other site 656519006485 Switch I region; other site 656519006486 G2 box; other site 656519006487 G3 box; other site 656519006488 Switch II region; other site 656519006489 G4 box; other site 656519006490 G5 box; other site 656519006491 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 656519006492 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 656519006493 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 656519006494 DNA-binding site [nucleotide binding]; DNA binding site 656519006495 RNA-binding motif; other site 656519006496 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 656519006497 DNA-binding site [nucleotide binding]; DNA binding site 656519006498 RNA-binding motif; other site 656519006499 tryptophan synthase; Region: PLN02591 656519006500 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 656519006501 substrate binding site [chemical binding]; other site 656519006502 active site 656519006503 catalytic residues [active] 656519006504 heterodimer interface [polypeptide binding]; other site 656519006505 tryptophan synthase, beta chain; Region: PLN02618 656519006506 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 656519006507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519006508 catalytic residue [active] 656519006509 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 656519006510 active site 656519006511 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 656519006512 active site 656519006513 ribulose/triose binding site [chemical binding]; other site 656519006514 phosphate binding site [ion binding]; other site 656519006515 substrate (anthranilate) binding pocket [chemical binding]; other site 656519006516 product (indole) binding pocket [chemical binding]; other site 656519006517 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 656519006518 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 656519006519 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 656519006520 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 656519006521 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 656519006522 glutamine binding [chemical binding]; other site 656519006523 catalytic triad [active] 656519006524 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 656519006525 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 656519006526 chorismate binding enzyme; Region: Chorismate_bind; cl10555 656519006527 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 656519006528 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 656519006529 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 656519006530 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 656519006531 dimer interface [polypeptide binding]; other site 656519006532 active site 656519006533 metal binding site [ion binding]; metal-binding site 656519006534 maltose phosphorylase; Provisional; Region: PRK13807 656519006535 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 656519006536 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 656519006537 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 656519006538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 656519006539 motif II; other site 656519006540 GAF domain; Region: GAF; cl00853 656519006541 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 656519006542 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 656519006543 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 656519006544 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 656519006545 catalytic residue [active] 656519006546 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 656519006547 putative dimer interface [polypeptide binding]; other site 656519006548 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 656519006549 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 656519006550 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 656519006551 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 656519006552 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 656519006553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519006554 phenylhydantoinase; Validated; Region: PRK08323 656519006555 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 656519006556 active site 656519006557 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 656519006558 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519006559 Walker A/P-loop; other site 656519006560 ATP binding site [chemical binding]; other site 656519006561 Q-loop/lid; other site 656519006562 ABC transporter signature motif; other site 656519006563 Walker B; other site 656519006564 D-loop; other site 656519006565 H-loop/switch region; other site 656519006566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519006567 dimer interface [polypeptide binding]; other site 656519006568 conserved gate region; other site 656519006569 putative PBP binding loops; other site 656519006570 ABC-ATPase subunit interface; other site 656519006571 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 656519006572 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656519006573 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 656519006574 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 656519006575 Transcriptional regulators [Transcription]; Region: PurR; COG1609 656519006576 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 656519006577 DNA binding site [nucleotide binding] 656519006578 domain linker motif; other site 656519006579 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 656519006580 ligand binding site [chemical binding]; other site 656519006581 dimerization interface [polypeptide binding]; other site 656519006582 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656519006583 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 656519006584 Integrase core domain; Region: rve; cl01316 656519006585 Predicted amidohydrolase [General function prediction only]; Region: COG0388 656519006586 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 656519006587 active site 656519006588 catalytic triad [active] 656519006589 dimer interface [polypeptide binding]; other site 656519006590 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 656519006591 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 656519006592 N-terminal plug; other site 656519006593 ligand-binding site [chemical binding]; other site 656519006594 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 656519006595 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 656519006596 Walker A/P-loop; other site 656519006597 ATP binding site [chemical binding]; other site 656519006598 Q-loop/lid; other site 656519006599 ABC transporter signature motif; other site 656519006600 Walker B; other site 656519006601 D-loop; other site 656519006602 H-loop/switch region; other site 656519006603 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 656519006604 ABC-ATPase subunit interface; other site 656519006605 dimer interface [polypeptide binding]; other site 656519006606 putative PBP binding regions; other site 656519006607 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 656519006608 intersubunit interface [polypeptide binding]; other site 656519006609 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 656519006610 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544 656519006611 homotrimer interface [polypeptide binding]; other site 656519006612 Walker A motif; other site 656519006613 GTP binding site [chemical binding]; other site 656519006614 Walker B motif; other site 656519006615 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 656519006616 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 656519006617 putative dimer interface [polypeptide binding]; other site 656519006618 active site pocket [active] 656519006619 putative cataytic base [active] 656519006620 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 656519006621 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 656519006622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519006623 homodimer interface [polypeptide binding]; other site 656519006624 catalytic residue [active] 656519006625 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 656519006626 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 656519006627 CobD/Cbib protein; Region: CobD_Cbib; cl00561 656519006628 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 656519006629 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 656519006630 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 656519006631 catalytic triad [active] 656519006632 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 656519006633 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 656519006634 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 656519006635 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 656519006636 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 656519006637 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 656519006638 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 656519006639 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 656519006640 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 656519006641 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 656519006642 active site 656519006643 C-terminal domain interface [polypeptide binding]; other site 656519006644 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 656519006645 active site 656519006646 N-terminal domain interface [polypeptide binding]; other site 656519006647 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 656519006648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 656519006649 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 656519006650 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 656519006651 CbiD; Region: CbiD; cl00828 656519006652 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 656519006653 Precorrin-8X methylmutase; Region: CbiC; pfam02570 656519006654 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 656519006655 Walker A motif; other site 656519006656 ATP binding site [chemical binding]; other site 656519006657 Walker B motif; other site 656519006658 cobyric acid synthase; Provisional; Region: PRK00784 656519006659 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 656519006660 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 656519006661 catalytic triad [active] 656519006662 cobyric acid synthase; Provisional; Region: PRK00784 656519006663 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 656519006664 catalytic triad [active] 656519006665 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 656519006666 catalytic core [active] 656519006667 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 656519006668 homodimer interaction site [polypeptide binding]; other site 656519006669 cofactor binding site; other site 656519006670 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 656519006671 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 656519006672 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 656519006673 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 656519006674 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 656519006675 ABC-ATPase subunit interface; other site 656519006676 dimer interface [polypeptide binding]; other site 656519006677 putative PBP binding regions; other site 656519006678 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 656519006679 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 656519006680 putative metal binding site [ion binding]; other site 656519006681 nickel responsive regulator; Provisional; Region: PRK04460 656519006682 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 656519006683 AIR carboxylase; Region: AIRC; cl00310 656519006684 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 656519006685 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 656519006686 Ligand Binding Site [chemical binding]; other site 656519006687 hypothetical protein; Provisional; Region: PRK00955 656519006688 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 656519006689 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-; Region: nylC_like; cd02252 656519006690 putative active site pocket [active] 656519006691 cleavage site 656519006692 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 656519006693 PhoU domain; Region: PhoU; pfam01895 656519006694 PhoU domain; Region: PhoU; pfam01895 656519006695 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 656519006696 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 656519006697 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 656519006698 catalytic residue [active] 656519006699 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 656519006700 AzlC protein; Region: AzlC; cl00570 656519006701 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 656519006702 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 656519006703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519006704 dimer interface [polypeptide binding]; other site 656519006705 conserved gate region; other site 656519006706 putative PBP binding loops; other site 656519006707 ABC-ATPase subunit interface; other site 656519006708 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 656519006709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519006710 dimer interface [polypeptide binding]; other site 656519006711 conserved gate region; other site 656519006712 putative PBP binding loops; other site 656519006713 ABC-ATPase subunit interface; other site 656519006714 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 656519006715 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 656519006716 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 656519006717 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 656519006718 catalytic triad [active] 656519006719 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 656519006720 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 656519006721 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 656519006722 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 656519006723 Walker A/P-loop; other site 656519006724 ATP binding site [chemical binding]; other site 656519006725 Q-loop/lid; other site 656519006726 ABC transporter signature motif; other site 656519006727 Walker B; other site 656519006728 D-loop; other site 656519006729 H-loop/switch region; other site 656519006730 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 656519006731 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 656519006732 ABC-ATPase subunit interface; other site 656519006733 dimer interface [polypeptide binding]; other site 656519006734 putative PBP binding regions; other site 656519006735 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 656519006736 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 656519006737 intersubunit interface [polypeptide binding]; other site 656519006738 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519006739 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 656519006740 Ligand binding site [chemical binding]; other site 656519006741 metal binding site [ion binding]; metal-binding site 656519006742 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 656519006743 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 656519006744 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 656519006745 DNA-binding site [nucleotide binding]; DNA binding site 656519006746 RNA-binding motif; other site 656519006747 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 656519006748 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 656519006749 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 656519006750 FeS/SAM binding site; other site 656519006751 ATP cone domain; Region: ATP-cone; pfam03477 656519006752 Class III ribonucleotide reductase; Region: RNR_III; cd01675 656519006753 effector binding site; other site 656519006754 active site 656519006755 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08332 656519006756 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 656519006757 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 656519006758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 656519006759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 656519006760 PAS domain S-box; Region: sensory_box; TIGR00229 656519006761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519006762 putative active site [active] 656519006763 heme pocket [chemical binding]; other site 656519006764 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 656519006765 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519006766 Zn2+ binding site [ion binding]; other site 656519006767 Mg2+ binding site [ion binding]; other site 656519006768 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 656519006769 Cation efflux family; Region: Cation_efflux; cl00316 656519006770 Transposase, Mutator family; Region: Transposase_mut; pfam00872 656519006771 MULE transposase domain; Region: MULE; pfam10551 656519006772 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 656519006773 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 656519006774 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 656519006775 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 656519006776 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 656519006777 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 656519006778 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 656519006779 purine monophosphate binding site [chemical binding]; other site 656519006780 dimer interface [polypeptide binding]; other site 656519006781 putative catalytic residues [active] 656519006782 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 656519006783 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 656519006784 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 656519006785 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 656519006786 active site 656519006787 substrate binding site [chemical binding]; other site 656519006788 cosubstrate binding site; other site 656519006789 catalytic site [active] 656519006790 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 656519006791 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 656519006792 dimerization interface [polypeptide binding]; other site 656519006793 putative ATP binding site [chemical binding]; other site 656519006794 amidophosphoribosyltransferase; Provisional; Region: PRK05793 656519006795 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 656519006796 active site 656519006797 tetramer interface [polypeptide binding]; other site 656519006798 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 656519006799 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 656519006800 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 656519006801 ATP binding site [chemical binding]; other site 656519006802 active site 656519006803 substrate binding site [chemical binding]; other site 656519006804 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 656519006805 Adenylsuccinate lyase (ASL)_like; Region: Adenylsuccinate_lyase_like; cd01595 656519006806 active site 656519006807 tetramer interface [polypeptide binding]; other site 656519006808 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 656519006809 AIR carboxylase; Region: AIRC; cl00310 656519006810 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 656519006811 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 656519006812 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 656519006813 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 656519006814 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 656519006815 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 656519006816 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 656519006817 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 656519006818 YibE/F-like protein; Region: YibE_F; cl02259 656519006819 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cd00016 656519006820 dimer interface [polypeptide binding]; other site 656519006821 active site 656519006822 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cl12039 656519006823 dimer interface [polypeptide binding]; other site 656519006824 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 656519006825 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 656519006826 putative active site [active] 656519006827 putative NTP binding site [chemical binding]; other site 656519006828 putative nucleic acid binding site [nucleotide binding]; other site 656519006829 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 656519006830 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 656519006831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 656519006832 active site 656519006833 phosphorylation site [posttranslational modification] 656519006834 intermolecular recognition site; other site 656519006835 dimerization interface [polypeptide binding]; other site 656519006836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519006837 Walker A motif; other site 656519006838 ATP binding site [chemical binding]; other site 656519006839 Walker B motif; other site 656519006840 arginine finger; other site 656519006841 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 656519006842 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 656519006843 dimer interface [polypeptide binding]; other site 656519006844 phosphorylation site [posttranslational modification] 656519006845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 656519006846 ATP binding site [chemical binding]; other site 656519006847 Mg2+ binding site [ion binding]; other site 656519006848 G-X-G motif; other site 656519006849 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656519006850 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 656519006851 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 656519006852 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 656519006853 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 656519006854 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 656519006855 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 656519006856 substrate binding site [chemical binding]; other site 656519006857 glutamase interaction surface [polypeptide binding]; other site 656519006858 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 656519006859 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 656519006860 catalytic residues [active] 656519006861 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 656519006862 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 656519006863 putative active site [active] 656519006864 oxyanion strand; other site 656519006865 catalytic triad [active] 656519006866 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 656519006867 putative active site pocket [active] 656519006868 4-fold oligomerization interface [polypeptide binding]; other site 656519006869 metal binding residues [ion binding]; metal-binding site 656519006870 3-fold/trimer interface [polypeptide binding]; other site 656519006871 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 656519006872 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 656519006873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519006874 homodimer interface [polypeptide binding]; other site 656519006875 catalytic residue [active] 656519006876 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 656519006877 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 656519006878 NAD binding site [chemical binding]; other site 656519006879 dimerization interface [polypeptide binding]; other site 656519006880 product binding site; other site 656519006881 substrate binding site [chemical binding]; other site 656519006882 zinc binding site [ion binding]; other site 656519006883 catalytic residues [active] 656519006884 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656519006885 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 656519006886 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 656519006887 dimer interface [polypeptide binding]; other site 656519006888 motif 1; other site 656519006889 active site 656519006890 motif 2; other site 656519006891 motif 3; other site 656519006892 histidinol phosphate phosphatase HisJ family; Region: hisJ_fam; TIGR01856 656519006893 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 656519006894 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 656519006895 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 656519006896 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 656519006897 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 656519006898 active site 656519006899 homotetramer interface [polypeptide binding]; other site 656519006900 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 656519006901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519006902 dimer interface [polypeptide binding]; other site 656519006903 conserved gate region; other site 656519006904 putative PBP binding loops; other site 656519006905 ABC-ATPase subunit interface; other site 656519006906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 656519006907 dimer interface [polypeptide binding]; other site 656519006908 conserved gate region; other site 656519006909 putative PBP binding loops; other site 656519006910 ABC-ATPase subunit interface; other site 656519006911 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 656519006912 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 656519006913 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 656519006914 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 656519006915 ligand binding site [chemical binding]; other site 656519006916 oligomer interface [polypeptide binding]; other site 656519006917 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 656519006918 dimer interface [polypeptide binding]; other site 656519006919 N-terminal domain interface [polypeptide binding]; other site 656519006920 sulfate 1 binding site; other site 656519006921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 656519006922 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 656519006923 putative substrate translocation pore; other site 656519006924 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 656519006925 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 656519006926 active site 656519006927 nucleophile elbow; other site 656519006928 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2-fam; cd01407 656519006929 NAD+ binding site [chemical binding]; other site 656519006930 substrate binding site [chemical binding]; other site 656519006931 Zn binding site [ion binding]; other site 656519006932 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 656519006933 active site 656519006934 phosphorylation site [posttranslational modification] 656519006935 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 656519006936 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 656519006937 dimer interface [polypeptide binding]; other site 656519006938 active site 656519006939 metal binding site [ion binding]; metal-binding site 656519006940 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 656519006941 MgtE intracellular N domain; Region: MgtE_N; cl15244 656519006942 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 656519006943 Divalent cation transporter; Region: MgtE; cl00786 656519006944 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 656519006945 dimerization domain swap beta strand [polypeptide binding]; other site 656519006946 regulatory protein interface [polypeptide binding]; other site 656519006947 active site 656519006948 regulatory phosphorylation site [posttranslational modification]; other site 656519006949 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 656519006950 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 656519006951 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 656519006952 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 656519006953 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 656519006954 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 656519006955 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 656519006956 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 656519006957 Glucitol operon activator protein (GutM); Region: GutM; cl01890 656519006958 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 656519006959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 656519006960 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 656519006961 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 656519006962 E3 interaction surface; other site 656519006963 lipoyl attachment site [posttranslational modification]; other site 656519006964 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 656519006965 e3 binding domain; Region: E3_binding; pfam02817 656519006966 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 656519006967 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 656519006968 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 656519006969 alpha subunit interface [polypeptide binding]; other site 656519006970 TPP binding site [chemical binding]; other site 656519006971 heterodimer interface [polypeptide binding]; other site 656519006972 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 656519006973 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 656519006974 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 656519006975 tetramer interface [polypeptide binding]; other site 656519006976 TPP-binding site [chemical binding]; other site 656519006977 heterodimer interface [polypeptide binding]; other site 656519006978 phosphorylation loop region [posttranslational modification] 656519006979 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 656519006980 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 656519006981 NAD(P) binding site [chemical binding]; other site 656519006982 SAF domain; Region: SAF; cl00555 656519006983 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 656519006984 PAS domain S-box; Region: sensory_box; TIGR00229 656519006985 PAS fold; Region: PAS_4; pfam08448 656519006986 PAS fold; Region: PAS_4; pfam08448 656519006987 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 656519006988 putative active site [active] 656519006989 heme pocket [chemical binding]; other site 656519006990 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519006991 metal binding site [ion binding]; metal-binding site 656519006992 active site 656519006993 I-site; other site 656519006994 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 656519006995 Zn2+ binding site [ion binding]; other site 656519006996 Mg2+ binding site [ion binding]; other site 656519006997 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 656519006998 active site 656519006999 metal binding site [ion binding]; metal-binding site 656519007000 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 656519007001 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 656519007002 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 656519007003 TraB family; Region: TraB; cl12050 656519007004 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 656519007005 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 656519007006 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 656519007007 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 656519007008 DNA-binding site [nucleotide binding]; DNA binding site 656519007009 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 656519007010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519007011 homodimer interface [polypeptide binding]; other site 656519007012 catalytic residue [active] 656519007013 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 656519007014 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 656519007015 active site 656519007016 multimer interface [polypeptide binding]; other site 656519007017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 656519007018 S-adenosylmethionine binding site [chemical binding]; other site 656519007019 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 656519007020 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 656519007021 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 656519007022 Cysteine-rich domain; Region: CCG; pfam02754 656519007023 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 656519007024 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 656519007025 putative inner membrane protein; Provisional; Region: PRK11099 656519007026 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 656519007027 CPxP motif; other site 656519007028 putative inner membrane protein; Provisional; Region: PRK11099 656519007029 YeeE/YedE family (DUF395); Region: DUF395; cl01018 656519007030 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 656519007031 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 656519007032 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 656519007033 active site residue [active] 656519007034 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 656519007035 active site residue [active] 656519007036 Integrase core domain; Region: rve; cl01316 656519007037 Ferritin-like domain; Region: Ferritin; pfam00210 656519007038 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 656519007039 dimerization interface [polypeptide binding]; other site 656519007040 DPS ferroxidase diiron center [ion binding]; other site 656519007041 ion pore; other site 656519007042 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 656519007043 Integrase core domain; Region: rve; cl01316 656519007044 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 656519007045 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519007046 Integrase core domain; Region: rve; cl01316 656519007047 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 656519007048 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 656519007049 putative transposase OrfB; Reviewed; Region: PHA02517 656519007050 Integrase core domain; Region: rve; cl01316 656519007051 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 656519007052 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 656519007053 MgtC family; Region: MgtC; cl12207 656519007054 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 656519007055 metal binding site [ion binding]; metal-binding site 656519007056 active site 656519007057 I-site; other site 656519007058 Putative serine esterase (DUF676); Region: DUF676; pfam05057 656519007059 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 656519007060 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 656519007061 dimer interface [polypeptide binding]; other site 656519007062 PYR/PP interface [polypeptide binding]; other site 656519007063 TPP binding site [chemical binding]; other site 656519007064 substrate binding site [chemical binding]; other site 656519007065 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 656519007066 Domain of unknown function; Region: EKR; pfam10371 656519007067 4Fe-4S binding domain; Region: Fer4; cl02805 656519007068 TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This subfamily also includes proteins characterized as...; Region: TPP_PFOR_PNO; cd03377 656519007069 TPP-binding site [chemical binding]; other site 656519007070 dimer interface [polypeptide binding]; other site 656519007071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 656519007072 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 656519007073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519007074 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 656519007075 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 656519007076 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 656519007077 Membrane protein of unknown function; Region: DUF360; cl00850 656519007078 cysteine synthases; Region: cysKM; TIGR01136 656519007079 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 656519007080 dimer interface [polypeptide binding]; other site 656519007081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519007082 catalytic residue [active] 656519007083 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 656519007084 serine O-acetyltransferase; Region: cysE; TIGR01172 656519007085 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 656519007086 trimer interface [polypeptide binding]; other site 656519007087 active site 656519007088 substrate binding site [chemical binding]; other site 656519007089 CoA binding site [chemical binding]; other site 656519007090 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 656519007091 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 656519007092 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 656519007093 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 656519007094 adenylosuccinate synthetase; Provisional; Region: PRK01117 656519007095 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 656519007096 GDP-binding site [chemical binding]; other site 656519007097 ACT binding site; other site 656519007098 IMP binding site; other site 656519007099 adenylosuccinate lyase; Provisional; Region: PRK07380 656519007100 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 656519007101 tetramer interface [polypeptide binding]; other site 656519007102 active site 656519007103 DNA replication protein DnaC; Validated; Region: PRK06835 656519007104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 656519007105 Walker A motif; other site 656519007106 ATP binding site [chemical binding]; other site 656519007107 Walker B motif; other site 656519007108 arginine finger; other site 656519007109 replicative DNA helicase; Region: DnaB; TIGR00665 656519007110 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 656519007111 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 656519007112 Walker A motif; other site 656519007113 ATP binding site [chemical binding]; other site 656519007114 Walker B motif; other site 656519007115 DNA binding loops [nucleotide binding] 656519007116 PspC domain; Region: PspC; cl00864 656519007117 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 656519007118 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 656519007119 FtsX-like permease family; Region: FtsX; pfam02687 656519007120 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 656519007121 FtsX-like permease family; Region: FtsX; pfam02687 656519007122 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 656519007123 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 656519007124 Walker A/P-loop; other site 656519007125 ATP binding site [chemical binding]; other site 656519007126 Q-loop/lid; other site 656519007127 ABC transporter signature motif; other site 656519007128 Walker B; other site 656519007129 D-loop; other site 656519007130 H-loop/switch region; other site 656519007131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 656519007132 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 656519007133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 656519007134 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 656519007135 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 656519007136 Ligand Binding Site [chemical binding]; other site 656519007137 Transcriptional regulators [Transcription]; Region: PurR; COG1609 656519007138 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 656519007139 DNA binding site [nucleotide binding] 656519007140 domain linker motif; other site 656519007141 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 656519007142 ligand binding site [chemical binding]; other site 656519007143 dimerization interface [polypeptide binding]; other site 656519007144 Membrane transport protein; Region: Mem_trans; cl09117 656519007145 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 656519007146 putative NAD(P) binding site [chemical binding]; other site 656519007147 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 656519007148 active site 656519007149 mannonate dehydratase; Provisional; Region: PRK03906 656519007150 mannonate dehydratase; Region: uxuA; TIGR00695 656519007151 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 656519007152 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 656519007153 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 656519007154 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 656519007155 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 656519007156 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 656519007157 dimer interface [polypeptide binding]; other site 656519007158 ssDNA binding site [nucleotide binding]; other site 656519007159 tetramer (dimer of dimers) interface [polypeptide binding]; other site 656519007160 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 656519007161 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 656519007162 active site 656519007163 GTP-binding protein YchF; Reviewed; Region: PRK09601 656519007164 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 656519007165 G1 box; other site 656519007166 GTP/Mg2+ binding site [chemical binding]; other site 656519007167 Switch I region; other site 656519007168 G2 box; other site 656519007169 Switch II region; other site 656519007170 G3 box; other site 656519007171 G4 box; other site 656519007172 G5 box; other site 656519007173 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 656519007174 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 656519007175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 656519007176 binding surface 656519007177 TPR motif; other site 656519007178 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 656519007179 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 656519007180 tetramer interface [polypeptide binding]; other site 656519007181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519007182 catalytic residue [active] 656519007183 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 656519007184 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 656519007185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 656519007186 tetramer interface [polypeptide binding]; other site 656519007187 catalytic residue [active] 656519007188 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 656519007189 lipoyl attachment site [posttranslational modification]; other site 656519007190 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 656519007191 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 656519007192 Protein of unknown function (DUF554); Region: DUF554; cl00784 656519007193 ParB-like partition proteins; Region: parB_part; TIGR00180 656519007194 ParB-like nuclease domain; Region: ParBc; cl02129 656519007195 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 656519007196 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 656519007197 P-loop; other site 656519007198 Magnesium ion binding site [ion binding]; other site 656519007199 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 656519007200 Magnesium ion binding site [ion binding]; other site 656519007201 ParB-like partition proteins; Region: parB_part; TIGR00180 656519007202 ParB-like nuclease domain; Region: ParBc; cl02129 656519007203 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 656519007204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 656519007205 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 656519007206 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 656519007207 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 656519007208 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 656519007209 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 656519007210 G1 box; other site 656519007211 GTP/Mg2+ binding site [chemical binding]; other site 656519007212 Switch I region; other site 656519007213 G2 box; other site 656519007214 Switch II region; other site 656519007215 G3 box; other site 656519007216 G4 box; other site 656519007217 G5 box; other site 656519007218 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 656519007219 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 656519007220 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 656519007221 G-X-X-G motif; other site 656519007222 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 656519007223 RxxxH motif; other site 656519007224 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 656519007225 Domain of unknown function DUF37; Region: DUF37; cl00506 656519007226 Ribonuclease P; Region: Ribonuclease_P; cl00457