-- dump date   	20140619_104856
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
862965000001	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
862965000002	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
862965000003	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
862965000004	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
862965000005	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
862965000006	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
862965000007	acyl-activating enzyme (AAE) consensus motif; other site
862965000008	putative AMP binding site [chemical binding]; other site
862965000009	putative active site [active]
862965000010	putative CoA binding site [chemical binding]; other site
862965000011	selenophosphate synthetase; Provisional; Region: PRK00943
862965000012	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
862965000013	dimerization interface [polypeptide binding]; other site
862965000014	putative ATP binding site [chemical binding]; other site
862965000015	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
862965000016	Domain of unknown function DUF21; Region: DUF21; pfam01595
862965000017	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
862965000018	Transporter associated domain; Region: CorC_HlyC; smart01091
862965000020	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
862965000021	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
862965000022	putative active site [active]
862965000023	oxyanion strand; other site
862965000024	catalytic triad [active]
862965000027	helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225
862965000028	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
862965000029	signal recognition particle protein; Provisional; Region: PRK10867
862965000030	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
862965000031	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
862965000032	P loop; other site
862965000033	GTP binding site [chemical binding]; other site
862965000034	Signal peptide binding domain; Region: SRP_SPB; pfam02978
862965000035	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
862965000036	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
862965000037	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862965000038	active site
862965000039	uracil-xanthine permease; Region: ncs2; TIGR00801
862965000040	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
862965000041	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
862965000042	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG3056
862965000043	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
862965000044	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
862965000045	putative metal binding site [ion binding]; other site
862965000046	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
862965000047	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
862965000048	catalytic residues [active]
862965000049	central insert; other site
862965000050	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
862965000051	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
862965000052	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
862965000053	heme exporter protein CcmC; Region: ccmC; TIGR01191
862965000054	heme exporter protein CcmB; Region: ccmB; TIGR01190
862965000055	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
862965000056	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965000057	Walker A/P-loop; other site
862965000058	ATP binding site [chemical binding]; other site
862965000059	Q-loop/lid; other site
862965000060	ABC transporter signature motif; other site
862965000061	Walker B; other site
862965000062	D-loop; other site
862965000063	H-loop/switch region; other site
862965000064	superoxide dismutase; Provisional; Region: PRK10925
862965000065	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
862965000066	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
862965000067	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
862965000068	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
862965000069	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
862965000070	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
862965000071	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
862965000072	dimer interface [polypeptide binding]; other site
862965000073	motif 1; other site
862965000074	active site
862965000075	motif 2; other site
862965000076	motif 3; other site
862965000077	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
862965000078	anticodon binding site; other site
862965000079	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
862965000080	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
862965000081	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
862965000082	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
862965000083	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
862965000084	non-specific DNA binding site [nucleotide binding]; other site
862965000085	salt bridge; other site
862965000086	sequence-specific DNA binding site [nucleotide binding]; other site
862965000087	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
862965000088	TPR repeat; Region: TPR_11; pfam13414
862965000089	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
862965000090	binding surface
862965000091	TPR motif; other site
862965000092	TPR repeat; Region: TPR_11; pfam13414
862965000093	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
862965000094	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862965000095	FeS/SAM binding site; other site
862965000096	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
862965000097	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
862965000098	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
862965000099	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
862965000100	metal binding site [ion binding]; metal-binding site
862965000101	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
862965000102	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
862965000103	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
862965000104	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
862965000105	ABC-ATPase subunit  interface; other site
862965000106	dimer interface [polypeptide binding]; other site
862965000107	putative PBP binding regions; other site
862965000108	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
862965000109	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
862965000110	ABC-ATPase subunit  interface; other site
862965000111	dimer interface [polypeptide binding]; other site
862965000112	putative PBP binding regions; other site
862965000113	Protein of unknown function DUF262; Region: DUF262; pfam03235
862965000114	Uncharacterized conserved protein [Function unknown]; Region: COG1479
862965000115	Protein of unknown function DUF262; Region: DUF262; pfam03235
862965000116	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
862965000117	23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522
862965000118	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862965000119	S-adenosylmethionine binding site [chemical binding]; other site
862965000120	beta-hexosaminidase; Provisional; Region: PRK05337
862965000121	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
862965000122	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
862965000123	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
862965000124	Putative periplasmic lipoprotein; Region: DUF1425; cl12345
862965000125	putative dimer interface [polypeptide binding]; other site
862965000126	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
862965000127	nucleotide binding site/active site [active]
862965000128	HIT family signature motif; other site
862965000129	catalytic residue [active]
862965000130	periplasmic folding chaperone; Provisional; Region: PRK10788
862965000131	SurA N-terminal domain; Region: SurA_N_3; cl07813
862965000132	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
862965000133	Predicted membrane protein [Function unknown]; Region: COG1971
862965000134	Domain of unknown function DUF; Region: DUF204; pfam02659
862965000135	Domain of unknown function DUF; Region: DUF204; pfam02659
862965000136	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
862965000137	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
862965000138	trmE is a tRNA modification GTPase; Region: trmE; cd04164
862965000139	G1 box; other site
862965000140	GTP/Mg2+ binding site [chemical binding]; other site
862965000141	Switch I region; other site
862965000142	G2 box; other site
862965000143	Switch II region; other site
862965000144	G3 box; other site
862965000145	G4 box; other site
862965000146	G5 box; other site
862965000147	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
862965000148	membrane protein insertase; Provisional; Region: PRK01318
862965000149	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
862965000150	hypothetical protein; Validated; Region: PRK00041
862965000151	ribonuclease P; Reviewed; Region: rnpA; PRK01732
862965000152	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
862965000153	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
862965000154	DnaA N-terminal domain; Region: DnaA_N; pfam11638
862965000155	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862965000156	Walker B motif; other site
862965000157	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
862965000158	arginine finger; other site
862965000159	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
862965000160	DnaA box-binding interface [nucleotide binding]; other site
862965000161	DNA polymerase III subunit beta; Validated; Region: PRK05643
862965000162	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
862965000163	putative DNA binding surface [nucleotide binding]; other site
862965000164	dimer interface [polypeptide binding]; other site
862965000165	beta-clamp/clamp loader binding surface; other site
862965000166	beta-clamp/translesion DNA polymerase binding surface; other site
862965000167	recF protein; Region: recf; TIGR00611
862965000168	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965000169	Walker A/P-loop; other site
862965000170	ATP binding site [chemical binding]; other site
862965000171	Q-loop/lid; other site
862965000172	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965000173	ABC transporter signature motif; other site
862965000174	Walker B; other site
862965000175	D-loop; other site
862965000176	H-loop/switch region; other site
862965000177	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
862965000178	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
862965000179	active site
862965000180	dimer interface [polypeptide binding]; other site
862965000181	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
862965000182	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
862965000183	active site
862965000184	trimer interface [polypeptide binding]; other site
862965000185	allosteric site; other site
862965000186	active site lid [active]
862965000187	hexamer (dimer of trimers) interface [polypeptide binding]; other site
862965000188	N-acetylneuraminate lyase; Provisional; Region: PRK04147
862965000189	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
862965000190	inhibitor site; inhibition site
862965000191	active site
862965000192	dimer interface [polypeptide binding]; other site
862965000193	catalytic residue [active]
862965000194	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
862965000195	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
862965000196	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
862965000197	putative active site [active]
862965000198	N-acetylmannosamine kinase; Provisional; Region: PRK05082
862965000199	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
862965000200	nucleotide binding site [chemical binding]; other site
862965000201	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
862965000202	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
862965000203	putative active site cavity [active]
862965000204	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
862965000205	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
862965000206	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
862965000207	active site turn [active]
862965000208	phosphorylation site [posttranslational modification]
862965000209	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
862965000210	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
862965000211	ligand binding site [chemical binding]; other site
862965000212	flexible hinge region; other site
862965000213	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
862965000214	putative switch regulator; other site
862965000215	non-specific DNA interactions [nucleotide binding]; other site
862965000216	DNA binding site [nucleotide binding]
862965000217	sequence specific DNA binding site [nucleotide binding]; other site
862965000218	putative cAMP binding site [chemical binding]; other site
862965000219	hypothetical protein; Provisional; Region: PRK04966
862965000220	division inhibitor protein; Provisional; Region: slmA; PRK09480
862965000221	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
862965000222	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
862965000223	trimer interface [polypeptide binding]; other site
862965000224	active site
862965000225	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
862965000226	Flavoprotein; Region: Flavoprotein; pfam02441
862965000227	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
862965000228	hypothetical protein; Reviewed; Region: PRK00024
862965000229	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
862965000230	MPN+ (JAMM) motif; other site
862965000231	Zinc-binding site [ion binding]; other site
862965000232	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
862965000233	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
862965000234	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
862965000235	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
862965000236	DNA binding site [nucleotide binding]
862965000237	catalytic residue [active]
862965000238	H2TH interface [polypeptide binding]; other site
862965000239	putative catalytic residues [active]
862965000240	turnover-facilitating residue; other site
862965000241	intercalation triad [nucleotide binding]; other site
862965000242	8OG recognition residue [nucleotide binding]; other site
862965000243	putative reading head residues; other site
862965000244	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
862965000245	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
862965000246	Protein of unknown function (DUF554); Region: DUF554; pfam04474
862965000247	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
862965000248	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
862965000249	trimer interface [polypeptide binding]; other site
862965000250	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
862965000251	YadA-like C-terminal region; Region: YadA; pfam03895
862965000252	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
862965000253	cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146
862965000254	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
862965000255	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
862965000256	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
862965000257	cytochrome c nitrate reductase biogenesis protein NrfE; Region: cyt_nit_nrfE; TIGR03145
862965000258	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
862965000259	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
862965000260	catalytic residues [active]
862965000261	central insert; other site
862965000262	cytochrome c nitrite reductase, accessory protein NrfF; Region: cyt_nit_nrfF; TIGR03147
862965000263	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
862965000264	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
862965000265	binding surface
862965000266	TPR motif; other site
862965000267	Predicted flavoproteins [General function prediction only]; Region: COG2081
862965000268	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
862965000269	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
862965000270	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
862965000271	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
862965000272	dimer interface [polypeptide binding]; other site
862965000273	tetramer interface [polypeptide binding]; other site
862965000274	PYR/PP interface [polypeptide binding]; other site
862965000275	TPP binding site [chemical binding]; other site
862965000276	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
862965000277	TPP-binding site; other site
862965000278	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
862965000279	chorismate binding enzyme; Region: Chorismate_bind; cl10555
862965000280	aminotransferase AlaT; Validated; Region: PRK09265
862965000281	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
862965000282	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862965000283	homodimer interface [polypeptide binding]; other site
862965000284	catalytic residue [active]
862965000285	Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589
862965000286	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
862965000287	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
862965000288	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
862965000289	putative acyl-acceptor binding pocket; other site
862965000290	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
862965000291	GTPase Era; Reviewed; Region: era; PRK00089
862965000292	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
862965000293	G1 box; other site
862965000294	GTP/Mg2+ binding site [chemical binding]; other site
862965000295	Switch I region; other site
862965000296	G2 box; other site
862965000297	Switch II region; other site
862965000298	G3 box; other site
862965000299	G4 box; other site
862965000300	G5 box; other site
862965000301	KH domain; Region: KH_2; pfam07650
862965000302	ribonuclease III; Reviewed; Region: rnc; PRK00102
862965000303	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
862965000304	dimerization interface [polypeptide binding]; other site
862965000305	active site
862965000306	metal binding site [ion binding]; metal-binding site
862965000307	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
862965000308	dsRNA binding site [nucleotide binding]; other site
862965000309	signal peptidase I; Provisional; Region: PRK10861
862965000310	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
862965000311	Catalytic site [active]
862965000312	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
862965000313	GTP-binding protein LepA; Provisional; Region: PRK05433
862965000314	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
862965000315	G1 box; other site
862965000316	putative GEF interaction site [polypeptide binding]; other site
862965000317	GTP/Mg2+ binding site [chemical binding]; other site
862965000318	Switch I region; other site
862965000319	G2 box; other site
862965000320	G3 box; other site
862965000321	Switch II region; other site
862965000322	G4 box; other site
862965000323	G5 box; other site
862965000324	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
862965000325	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
862965000326	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
862965000327	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
862965000328	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
862965000329	ligand binding site [chemical binding]; other site
862965000330	active site
862965000331	UGI interface [polypeptide binding]; other site
862965000332	catalytic site [active]
862965000333	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
862965000334	nucleoside/Zn binding site; other site
862965000335	dimer interface [polypeptide binding]; other site
862965000336	catalytic motif [active]
862965000337	thymidylate synthase; Reviewed; Region: thyA; PRK01827
862965000338	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
862965000339	dimerization interface [polypeptide binding]; other site
862965000340	active site
862965000341	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
862965000342	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
862965000343	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
862965000344	putative active site [active]
862965000345	Ap4A binding site [chemical binding]; other site
862965000346	nudix motif; other site
862965000347	putative metal binding site [ion binding]; other site
862965000348	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
862965000349	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
862965000350	amidase catalytic site [active]
862965000351	Zn binding residues [ion binding]; other site
862965000352	substrate binding site [chemical binding]; other site
862965000353	putative major pilin subunit; Provisional; Region: PRK10574
862965000354	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
862965000355	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
862965000356	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
862965000357	Walker A motif; other site
862965000358	ATP binding site [chemical binding]; other site
862965000359	Walker B motif; other site
862965000360	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
862965000361	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
862965000362	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
862965000363	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
862965000364	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
862965000365	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
862965000366	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
862965000367	CoA-binding site [chemical binding]; other site
862965000368	ATP-binding [chemical binding]; other site
862965000369	DNA gyrase inhibitor; Reviewed; Region: PRK00418
862965000370	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862965000371	Coenzyme A binding pocket [chemical binding]; other site
862965000372	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
862965000373	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
862965000374	ATP binding site [chemical binding]; other site
862965000375	Mg++ binding site [ion binding]; other site
862965000376	motif III; other site
862965000377	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862965000378	nucleotide binding region [chemical binding]; other site
862965000379	ATP-binding site [chemical binding]; other site
862965000380	rod shape-determining protein MreD; Region: MreD; cl01087
862965000381	rod shape-determining protein MreC; Region: mreC; TIGR00219
862965000382	rod shape-determining protein MreC; Region: MreC; pfam04085
862965000383	rod shape-determining protein MreB; Provisional; Region: PRK13927
862965000384	MreB and similar proteins; Region: MreB_like; cd10225
862965000385	nucleotide binding site [chemical binding]; other site
862965000386	Mg binding site [ion binding]; other site
862965000387	putative protofilament interaction site [polypeptide binding]; other site
862965000388	RodZ interaction site [polypeptide binding]; other site
862965000389	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
862965000390	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
862965000391	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
862965000392	putative transporter; Validated; Region: PRK03818
862965000393	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
862965000394	TrkA-C domain; Region: TrkA_C; pfam02080
862965000395	TrkA-C domain; Region: TrkA_C; pfam02080
862965000396	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
862965000397	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
862965000398	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
862965000399	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
862965000400	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
862965000401	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
862965000402	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
862965000403	rare lipoprotein A; Region: rlpA; TIGR00413
862965000404	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
862965000405	Sporulation related domain; Region: SPOR; cl10051
862965000406	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
862965000407	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
862965000408	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
862965000409	hypothetical protein; Provisional; Region: PRK04998
862965000410	lipoate-protein ligase B; Provisional; Region: PRK14342
862965000411	lipoyl synthase; Provisional; Region: PRK05481
862965000412	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862965000413	FeS/SAM binding site; other site
862965000414	adenylate kinase; Reviewed; Region: adk; PRK00279
862965000415	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
862965000416	AMP-binding site [chemical binding]; other site
862965000417	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
862965000418	muropeptide transporter; Reviewed; Region: ampG; PRK11902
862965000419	AmpG-like permease; Region: 2A0125; TIGR00901
862965000420	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
862965000421	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
862965000422	NAD binding site [chemical binding]; other site
862965000423	homodimer interface [polypeptide binding]; other site
862965000424	active site
862965000425	substrate binding site [chemical binding]; other site
862965000426	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
862965000427	catalytic triad [active]
862965000428	putative active site [active]
862965000429	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
862965000430	Autotransporter beta-domain; Region: Autotransporter; pfam03797
862965000431	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
862965000432	dimer interface [polypeptide binding]; other site
862965000433	substrate binding site [chemical binding]; other site
862965000434	metal binding sites [ion binding]; metal-binding site
862965000435	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
862965000436	putative protease; Provisional; Region: PRK15452
862965000437	Peptidase family U32; Region: Peptidase_U32; pfam01136
862965000438	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
862965000439	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
862965000440	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
862965000441	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
862965000442	Hemerythrin-like domain; Region: Hr-like; cd12108
862965000443	Fe binding site [ion binding]; other site
862965000444	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
862965000445	CPxP  motif; other site
862965000446	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
862965000447	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
862965000448	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
862965000449	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
862965000450	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
862965000451	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
862965000452	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
862965000453	Protein export membrane protein; Region: SecD_SecF; pfam02355
862965000454	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
862965000455	Domain of unknown function DUF20; Region: UPF0118; pfam01594
862965000456	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
862965000457	Nitrogen regulatory protein P-II; Region: P-II; smart00938
862965000458	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
862965000459	MPT binding site; other site
862965000460	trimer interface [polypeptide binding]; other site
862965000461	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
862965000462	Clp amino terminal domain; Region: Clp_N; pfam02861
862965000463	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862965000464	Walker A motif; other site
862965000465	ATP binding site [chemical binding]; other site
862965000466	Walker B motif; other site
862965000467	arginine finger; other site
862965000468	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862965000469	Walker A motif; other site
862965000470	ATP binding site [chemical binding]; other site
862965000471	Walker B motif; other site
862965000472	arginine finger; other site
862965000473	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
862965000474	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
862965000475	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
862965000476	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
862965000477	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
862965000478	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
862965000479	RNA binding surface [nucleotide binding]; other site
862965000480	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
862965000481	active site
862965000482	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
862965000483	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
862965000484	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
862965000485	hypothetical protein; Validated; Region: PRK00228
862965000486	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
862965000487	RNA methyltransferase, RsmE family; Region: TIGR00046
862965000488	fatty acid metabolism regulator; Provisional; Region: PRK04984
862965000489	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
862965000490	DNA-binding site [nucleotide binding]; DNA binding site
862965000491	FadR C-terminal domain; Region: FadR_C; pfam07840
862965000492	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
862965000493	disulfide bond formation protein B; Provisional; Region: PRK01749
862965000494	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
862965000495	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
862965000496	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
862965000497	TPR motif; other site
862965000498	binding surface
862965000499	Sel1-like repeats; Region: SEL1; smart00671
862965000500	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
862965000501	Sel1-like repeats; Region: SEL1; smart00671
862965000502	Sel1 repeat; Region: Sel1; pfam08238
862965000503	Sel1-like repeats; Region: SEL1; smart00671
862965000504	Sel1-like repeats; Region: SEL1; smart00671
862965000505	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
862965000506	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
862965000507	dimer interface [polypeptide binding]; other site
862965000508	active site
862965000509	glycine-pyridoxal phosphate binding site [chemical binding]; other site
862965000510	folate binding site [chemical binding]; other site
862965000511	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
862965000512	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
862965000513	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
862965000514	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
862965000515	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
862965000516	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
862965000517	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
862965000518	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
862965000519	purine monophosphate binding site [chemical binding]; other site
862965000520	dimer interface [polypeptide binding]; other site
862965000521	putative catalytic residues [active]
862965000522	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
862965000523	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
862965000524	Predicted membrane protein [Function unknown]; Region: COG2259
862965000525	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
862965000526	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
862965000527	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
862965000528	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
862965000529	DsbD alpha interface [polypeptide binding]; other site
862965000530	catalytic residues [active]
862965000531	two-component response regulator; Provisional; Region: PRK11173
862965000532	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862965000533	active site
862965000534	phosphorylation site [posttranslational modification]
862965000535	intermolecular recognition site; other site
862965000536	dimerization interface [polypeptide binding]; other site
862965000537	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
862965000538	DNA binding site [nucleotide binding]
862965000539	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
862965000540	SmpB-tmRNA interface; other site
862965000541	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
862965000542	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
862965000543	GTPase CgtA; Reviewed; Region: obgE; PRK12298
862965000544	GTP1/OBG; Region: GTP1_OBG; pfam01018
862965000545	Obg GTPase; Region: Obg; cd01898
862965000546	G1 box; other site
862965000547	GTP/Mg2+ binding site [chemical binding]; other site
862965000548	Switch I region; other site
862965000549	G2 box; other site
862965000550	G3 box; other site
862965000551	Switch II region; other site
862965000552	G4 box; other site
862965000553	G5 box; other site
862965000554	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
862965000555	EamA-like transporter family; Region: EamA; pfam00892
862965000556	EamA-like transporter family; Region: EamA; pfam00892
862965000557	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
862965000558	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
862965000559	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
862965000560	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
862965000561	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
862965000562	substrate binding pocket [chemical binding]; other site
862965000563	chain length determination region; other site
862965000564	substrate-Mg2+ binding site; other site
862965000565	catalytic residues [active]
862965000566	aspartate-rich region 1; other site
862965000567	active site lid residues [active]
862965000568	aspartate-rich region 2; other site
862965000569	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
862965000570	Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division,    chromosome partitioning]; Region: zapA; COG3027
862965000571	DNA polymerase I; Provisional; Region: PRK05755
862965000572	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
862965000573	active site
862965000574	metal binding site 1 [ion binding]; metal-binding site
862965000575	putative 5' ssDNA interaction site; other site
862965000576	metal binding site 3; metal-binding site
862965000577	metal binding site 2 [ion binding]; metal-binding site
862965000578	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
862965000579	putative DNA binding site [nucleotide binding]; other site
862965000580	putative metal binding site [ion binding]; other site
862965000581	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
862965000582	active site
862965000583	catalytic site [active]
862965000584	substrate binding site [chemical binding]; other site
862965000585	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
862965000586	active site
862965000587	DNA binding site [nucleotide binding]
862965000588	catalytic site [active]
862965000589	Cupin domain; Region: Cupin_2; cl17218
862965000590	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
862965000591	Sulphur transport; Region: Sulf_transp; pfam04143
862965000592	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
862965000593	CPxP  motif; other site
862965000594	Domain of unknown function (DUF386); Region: DUF386; cl01047
862965000595	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
862965000596	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
862965000597	RNase E interface [polypeptide binding]; other site
862965000598	trimer interface [polypeptide binding]; other site
862965000599	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
862965000600	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
862965000601	RNase E interface [polypeptide binding]; other site
862965000602	trimer interface [polypeptide binding]; other site
862965000603	active site
862965000604	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
862965000605	putative nucleic acid binding region [nucleotide binding]; other site
862965000606	G-X-X-G motif; other site
862965000607	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
862965000608	RNA binding site [nucleotide binding]; other site
862965000609	domain interface; other site
862965000610	Lipoprotein NlpI, contains TPR repeats [General function prediction only]; Region: NlpI; COG4785
862965000611	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
862965000612	binding surface
862965000613	TPR motif; other site
862965000614	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
862965000615	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
862965000616	ATP binding site [chemical binding]; other site
862965000617	Mg++ binding site [ion binding]; other site
862965000618	motif III; other site
862965000619	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862965000620	nucleotide binding region [chemical binding]; other site
862965000621	ATP-binding site [chemical binding]; other site
862965000622	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
862965000623	putative RNA binding site [nucleotide binding]; other site
862965000624	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
862965000625	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
862965000626	substrate binding pocket [chemical binding]; other site
862965000627	membrane-bound complex binding site; other site
862965000628	hinge residues; other site
862965000629	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
862965000630	N-acetyl-D-glucosamine binding site [chemical binding]; other site
862965000631	catalytic residue [active]
862965000632	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
862965000633	Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298
862965000634	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
862965000635	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
862965000636	N-terminal plug; other site
862965000637	ligand-binding site [chemical binding]; other site
862965000638	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
862965000639	30S subunit binding site; other site
862965000640	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
862965000641	amino acid carrier protein; Region: agcS; TIGR00835
862965000642	transketolase; Reviewed; Region: PRK12753
862965000643	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
862965000644	TPP-binding site [chemical binding]; other site
862965000645	dimer interface [polypeptide binding]; other site
862965000646	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
862965000647	PYR/PP interface [polypeptide binding]; other site
862965000648	dimer interface [polypeptide binding]; other site
862965000649	TPP binding site [chemical binding]; other site
862965000650	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
862965000651	Bacterial virulence factor haemolysin; Region: SMP_2; cl11479
862965000652	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
862965000653	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
862965000654	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862965000655	motif II; other site
862965000656	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
862965000657	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
862965000658	argininosuccinate lyase; Provisional; Region: PRK04833
862965000659	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
862965000660	active sites [active]
862965000661	tetramer interface [polypeptide binding]; other site
862965000662	transcription termination factor Rho; Provisional; Region: rho; PRK09376
862965000663	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
862965000664	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
862965000665	RNA binding site [nucleotide binding]; other site
862965000666	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
862965000667	multimer interface [polypeptide binding]; other site
862965000668	Walker A motif; other site
862965000669	ATP binding site [chemical binding]; other site
862965000670	Walker B motif; other site
862965000671	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
862965000672	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
862965000673	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
862965000674	RimM N-terminal domain; Region: RimM; pfam01782
862965000675	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
862965000676	glutamate dehydrogenase; Provisional; Region: PRK09414
862965000677	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
862965000678	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
862965000679	NAD(P) binding site [chemical binding]; other site
862965000680	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
862965000681	dimer interface [polypeptide binding]; other site
862965000682	allosteric magnesium binding site [ion binding]; other site
862965000683	active site
862965000684	aspartate-rich active site metal binding site; other site
862965000685	Schiff base residues; other site
862965000686	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
862965000687	sec-independent translocase; Provisional; Region: PRK01770
862965000688	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
862965000689	BCCT family transporter; Region: BCCT; pfam02028
862965000690	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
862965000691	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
862965000692	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
862965000693	Ligand Binding Site [chemical binding]; other site
862965000694	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
862965000695	active site 1 [active]
862965000696	dimer interface [polypeptide binding]; other site
862965000697	hexamer interface [polypeptide binding]; other site
862965000698	active site 2 [active]
862965000699	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991
862965000700	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
862965000701	ApbE family; Region: ApbE; pfam02424
862965000702	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
862965000703	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
862965000704	FAD binding pocket [chemical binding]; other site
862965000705	FAD binding motif [chemical binding]; other site
862965000706	phosphate binding motif [ion binding]; other site
862965000707	beta-alpha-beta structure motif; other site
862965000708	NAD binding pocket [chemical binding]; other site
862965000709	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
862965000710	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
862965000711	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
862965000712	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
862965000713	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
862965000714	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
862965000715	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
862965000716	E3 interaction surface; other site
862965000717	lipoyl attachment site [posttranslational modification]; other site
862965000718	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
862965000719	BolA-like protein; Region: BolA; cl00386
862965000720	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
862965000721	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
862965000722	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
862965000723	Cl binding site [ion binding]; other site
862965000724	oligomer interface [polypeptide binding]; other site
862965000725	YGGT family; Region: YGGT; pfam02325
862965000726	YGGT family; Region: YGGT; pfam02325
862965000727	hypothetical protein; Validated; Region: PRK05090
862965000728	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
862965000729	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
862965000730	HIGH motif; other site
862965000731	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
862965000732	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
862965000733	active site
862965000734	KMSKS motif; other site
862965000735	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
862965000736	tRNA binding surface [nucleotide binding]; other site
862965000737	Rare lipoprotein B [Cell envelope biogenesis, outer membrane]; Region: RlpB; COG2980
862965000738	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
862965000739	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
862965000740	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
862965000741	Sulfatase; Region: Sulfatase; cl17466
862965000742	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
862965000743	active site
862965000744	8-oxo-dGMP binding site [chemical binding]; other site
862965000745	nudix motif; other site
862965000746	metal binding site [ion binding]; metal-binding site
862965000747	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
862965000748	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
862965000749	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
862965000750	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
862965000751	nucleotide binding region [chemical binding]; other site
862965000752	ATP-binding site [chemical binding]; other site
862965000753	SEC-C motif; Region: SEC-C; pfam02810
862965000754	Protein of unknown function (DUF2547); Region: DUF2547; pfam10818
862965000755	Protein of unknown function (DUF721); Region: DUF721; cl02324
862965000756	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
862965000757	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
862965000758	active site
862965000759	dimer interface [polypeptide binding]; other site
862965000760	metal binding site [ion binding]; metal-binding site
862965000761	shikimate kinase; Reviewed; Region: aroK; PRK00131
862965000762	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
862965000763	ADP binding site [chemical binding]; other site
862965000764	magnesium binding site [ion binding]; other site
862965000765	putative shikimate binding site; other site
862965000766	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
862965000767	Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040
862965000768	acyl carrier protein; Provisional; Region: acpP; PRK00982
862965000769	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
862965000770	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
862965000771	NAD(P) binding site [chemical binding]; other site
862965000772	homotetramer interface [polypeptide binding]; other site
862965000773	homodimer interface [polypeptide binding]; other site
862965000774	active site
862965000775	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
862965000776	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
862965000777	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
862965000778	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
862965000779	dimer interface [polypeptide binding]; other site
862965000780	active site
862965000781	CoA binding pocket [chemical binding]; other site
862965000782	putative phosphate acyltransferase; Provisional; Region: PRK05331
862965000783	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
862965000784	hypothetical protein; Provisional; Region: PRK11193
862965000785	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
862965000786	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862965000787	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
862965000788	Walker A/P-loop; other site
862965000789	ATP binding site [chemical binding]; other site
862965000790	Q-loop/lid; other site
862965000791	ABC transporter signature motif; other site
862965000792	Walker B; other site
862965000793	D-loop; other site
862965000794	H-loop/switch region; other site
862965000795	Cupin; Region: Cupin_6; pfam12852
862965000796	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
862965000797	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
862965000798	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
862965000799	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
862965000800	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
862965000801	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
862965000802	putative active site [active]
862965000803	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
862965000804	3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723
862965000805	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
862965000806	active site
862965000807	ATP binding site [chemical binding]; other site
862965000808	glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211
862965000809	tRNA binding surface [nucleotide binding]; other site
862965000810	anticodon binding site; other site
862965000811	DALR anticodon binding domain; Region: DALR_1; pfam05746
862965000812	Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764
862965000813	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
862965000814	putative active site [active]
862965000815	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
862965000816	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
862965000817	catalytic core [active]
862965000818	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
862965000819	Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545
862965000820	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
862965000821	heme-binding site [chemical binding]; other site
862965000822	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
862965000823	dimer interface [polypeptide binding]; other site
862965000824	motif 1; other site
862965000825	active site
862965000826	motif 2; other site
862965000827	motif 3; other site
862965000828	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
862965000829	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
862965000830	N-terminal plug; other site
862965000831	ligand-binding site [chemical binding]; other site
862965000832	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
862965000833	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
862965000834	intersubunit interface [polypeptide binding]; other site
862965000835	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
862965000836	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
862965000837	ABC-ATPase subunit  interface; other site
862965000838	dimer interface [polypeptide binding]; other site
862965000839	putative PBP binding regions; other site
862965000840	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
862965000841	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
862965000842	Walker A/P-loop; other site
862965000843	ATP binding site [chemical binding]; other site
862965000844	Q-loop/lid; other site
862965000845	ABC transporter signature motif; other site
862965000846	Walker B; other site
862965000847	D-loop; other site
862965000848	H-loop/switch region; other site
862965000849	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
862965000850	active site
862965000851	multimer interface [polypeptide binding]; other site
862965000852	aminopeptidase B; Provisional; Region: PRK05015
862965000853	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
862965000854	interface (dimer of trimers) [polypeptide binding]; other site
862965000855	Substrate-binding/catalytic site; other site
862965000856	Zn-binding sites [ion binding]; other site
862965000857	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
862965000858	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
862965000859	NAD binding site [chemical binding]; other site
862965000860	substrate binding site [chemical binding]; other site
862965000861	homodimer interface [polypeptide binding]; other site
862965000862	active site
862965000863	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
862965000864	O-Antigen ligase; Region: Wzy_C; pfam04932
862965000865	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
862965000866	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
862965000867	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
862965000868	NAD(P) binding site [chemical binding]; other site
862965000869	homodimer interface [polypeptide binding]; other site
862965000870	substrate binding site [chemical binding]; other site
862965000871	active site
862965000872	Bacterial sugar transferase; Region: Bac_transf; pfam02397
862965000873	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
862965000874	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
862965000875	inhibitor-cofactor binding pocket; inhibition site
862965000876	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862965000877	catalytic residue [active]
862965000878	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
862965000879	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
862965000880	active site
862965000881	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
862965000882	active site
862965000883	Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922
862965000884	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
862965000885	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
862965000886	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
862965000887	trimer interface [polypeptide binding]; other site
862965000888	active site
862965000889	substrate binding site [chemical binding]; other site
862965000890	CoA binding site [chemical binding]; other site
862965000891	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
862965000892	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
862965000893	active site
862965000894	homodimer interface [polypeptide binding]; other site
862965000895	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
862965000896	ligand binding site; other site
862965000897	tetramer interface; other site
862965000898	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
862965000899	active site
862965000900	catalytic triad [active]
862965000901	oxyanion hole [active]
862965000902	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
862965000903	NeuB family; Region: NeuB; pfam03102
862965000904	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
862965000905	NeuB binding interface [polypeptide binding]; other site
862965000906	putative substrate binding site [chemical binding]; other site
862965000907	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
862965000908	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
862965000909	putative trimer interface [polypeptide binding]; other site
862965000910	putative CoA binding site [chemical binding]; other site
862965000911	Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765
862965000912	Chain length determinant protein; Region: Wzz; cl15801
862965000913	glutamine synthetase; Provisional; Region: glnA; PRK09469
862965000914	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
862965000915	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
862965000916	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
862965000917	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
862965000918	G1 box; other site
862965000919	putative GEF interaction site [polypeptide binding]; other site
862965000920	GTP/Mg2+ binding site [chemical binding]; other site
862965000921	Switch I region; other site
862965000922	G2 box; other site
862965000923	G3 box; other site
862965000924	Switch II region; other site
862965000925	G4 box; other site
862965000926	G5 box; other site
862965000927	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
862965000928	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
862965000929	DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974
862965000930	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
862965000931	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
862965000932	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
862965000933	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862965000934	putative substrate translocation pore; other site
862965000935	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
862965000936	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
862965000937	active site
862965000938	Int/Topo IB signature motif; other site
862965000939	FRG domain; Region: FRG; pfam08867
862965000940	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
862965000941	fructuronate transporter; Provisional; Region: PRK10034; cl15264
862965000942	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
862965000943	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
862965000944	HD domain; Region: HD_4; pfam13328
862965000945	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
862965000946	synthetase active site [active]
862965000947	NTP binding site [chemical binding]; other site
862965000948	metal binding site [ion binding]; metal-binding site
862965000949	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
862965000950	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
862965000951	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
862965000952	TRAM domain; Region: TRAM; pfam01938
862965000953	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862965000954	S-adenosylmethionine binding site [chemical binding]; other site
862965000955	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
862965000956	Recombination protein O N terminal; Region: RecO_N; pfam11967
862965000957	Recombination protein O C terminal; Region: RecO_C; pfam02565
862965000958	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
862965000959	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
862965000960	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862965000961	FeS/SAM binding site; other site
862965000962	elongation factor P; Validated; Region: PRK00529
862965000963	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
862965000964	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
862965000965	RNA binding site [nucleotide binding]; other site
862965000966	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
862965000967	RNA binding site [nucleotide binding]; other site
862965000968	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
862965000969	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
862965000970	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862965000971	FeS/SAM binding site; other site
862965000972	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
862965000973	Pyruvate formate lyase 1; Region: PFL1; cd01678
862965000974	coenzyme A binding site [chemical binding]; other site
862965000975	active site
862965000976	catalytic residues [active]
862965000977	glycine loop; other site
862965000978	formate transporter FocA; Region: formate_focA; TIGR04060
862965000979	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
862965000980	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
862965000981	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
862965000982	active site
862965000983	dimerization interface [polypeptide binding]; other site
862965000984	Domain of unknown function (DUF305); Region: DUF305; cl17794
862965000985	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
862965000986	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
862965000987	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
862965000988	lipoprotein signal peptidase; Provisional; Region: PRK14787
862965000989	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
862965000990	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
862965000991	Substrate binding site; other site
862965000992	Mg++ binding site; other site
862965000993	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
862965000994	active site
862965000995	substrate binding site [chemical binding]; other site
862965000996	CoA binding site [chemical binding]; other site
862965000997	CTP synthetase; Validated; Region: pyrG; PRK05380
862965000998	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
862965000999	Catalytic site [active]
862965001000	active site
862965001001	UTP binding site [chemical binding]; other site
862965001002	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
862965001003	active site
862965001004	putative oxyanion hole; other site
862965001005	catalytic triad [active]
862965001006	aromatic amino acid exporter; Provisional; Region: PRK11689
862965001007	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
862965001008	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
862965001009	active site
862965001010	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
862965001011	enolase; Provisional; Region: eno; PRK00077
862965001012	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
862965001013	dimer interface [polypeptide binding]; other site
862965001014	metal binding site [ion binding]; metal-binding site
862965001015	substrate binding pocket [chemical binding]; other site
862965001016	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
862965001017	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
862965001018	nudix motif; other site
862965001019	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4316
862965001020	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
862965001021	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862965001022	active site
862965001023	motif I; other site
862965001024	motif II; other site
862965001025	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
862965001026	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
862965001027	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
862965001028	dimer interface [polypeptide binding]; other site
862965001029	active site
862965001030	metal binding site [ion binding]; metal-binding site
862965001031	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
862965001032	mRNA/rRNA interface [nucleotide binding]; other site
862965001033	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
862965001034	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
862965001035	23S rRNA interface [nucleotide binding]; other site
862965001036	L7/L12 interface [polypeptide binding]; other site
862965001037	putative thiostrepton binding site; other site
862965001038	L25 interface [polypeptide binding]; other site
862965001039	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
862965001040	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
862965001041	putative homodimer interface [polypeptide binding]; other site
862965001042	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
862965001043	heterodimer interface [polypeptide binding]; other site
862965001044	homodimer interface [polypeptide binding]; other site
862965001045	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
862965001046	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
862965001047	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
862965001048	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
862965001049	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862965001050	Walker A motif; other site
862965001051	ATP binding site [chemical binding]; other site
862965001052	Walker B motif; other site
862965001053	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
862965001054	Clp protease; Region: CLP_protease; pfam00574
862965001055	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
862965001056	oligomer interface [polypeptide binding]; other site
862965001057	active site residues [active]
862965001058	trigger factor; Provisional; Region: tig; PRK01490
862965001059	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
862965001060	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
862965001061	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
862965001062	BON domain; Region: BON; pfam04972
862965001063	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
862965001064	Predicted metalloprotease [General function prediction only]; Region: COG2321
862965001065	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
862965001066	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
862965001067	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
862965001068	active site
862965001069	HIGH motif; other site
862965001070	nucleotide binding site [chemical binding]; other site
862965001071	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
862965001072	active site
862965001073	KMSKS motif; other site
862965001074	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
862965001075	tRNA binding surface [nucleotide binding]; other site
862965001076	anticodon binding site; other site
862965001077	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
862965001078	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
862965001079	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
862965001080	active site
862965001081	Riboflavin kinase; Region: Flavokinase; smart00904
862965001082	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
862965001083	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
862965001084	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
862965001085	exoribonuclease R; Provisional; Region: PRK11642
862965001086	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
862965001087	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
862965001088	RNB domain; Region: RNB; pfam00773
862965001089	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
862965001090	RNA binding site [nucleotide binding]; other site
862965001091	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
862965001092	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
862965001093	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
862965001094	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
862965001095	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
862965001096	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
862965001097	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
862965001098	HlyD family secretion protein; Region: HlyD_3; pfam13437
862965001099	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
862965001100	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862965001101	putative substrate translocation pore; other site
862965001102	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
862965001103	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
862965001104	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
862965001105	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
862965001106	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
862965001107	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
862965001108	dimer interface [polypeptide binding]; other site
862965001109	ssDNA binding site [nucleotide binding]; other site
862965001110	tetramer (dimer of dimers) interface [polypeptide binding]; other site
862965001111	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
862965001112	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
862965001113	active site residue [active]
862965001114	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
862965001115	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
862965001116	putative active site [active]
862965001117	metal binding site [ion binding]; metal-binding site
862965001118	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
862965001119	non-specific DNA binding site [nucleotide binding]; other site
862965001120	salt bridge; other site
862965001121	sequence-specific DNA binding site [nucleotide binding]; other site
862965001122	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
862965001123	putative active site [active]
862965001124	putative NTP binding site [chemical binding]; other site
862965001125	putative nucleic acid binding site [nucleotide binding]; other site
862965001126	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
862965001127	Dicarboxylate transport; Region: DctA-YdbH; cl14674
862965001128	Protein of unknown function, DUF606; Region: DUF606; pfam04657
862965001129	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
862965001130	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
862965001131	active pocket/dimerization site; other site
862965001132	active site
862965001133	phosphorylation site [posttranslational modification]
862965001134	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
862965001135	active site
862965001136	phosphorylation site [posttranslational modification]
862965001137	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
862965001138	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
862965001139	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
862965001140	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
862965001141	Uncharacterized conserved protein [Function unknown]; Region: COG2128
862965001142	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
862965001143	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
862965001144	catalytic residues [active]
862965001145	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
862965001146	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
862965001147	SelR domain; Region: SelR; pfam01641
862965001148	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
862965001149	EamA-like transporter family; Region: EamA; cl17759
862965001150	iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411
862965001151	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
862965001152	siderophore binding site; other site
862965001153	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
862965001154	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
862965001155	ABC-ATPase subunit  interface; other site
862965001156	dimer interface [polypeptide binding]; other site
862965001157	putative PBP binding regions; other site
862965001158	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
862965001159	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
862965001160	ABC-ATPase subunit  interface; other site
862965001161	dimer interface [polypeptide binding]; other site
862965001162	putative PBP binding regions; other site
862965001163	iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231
862965001164	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
862965001165	Walker A/P-loop; other site
862965001166	ATP binding site [chemical binding]; other site
862965001167	Q-loop/lid; other site
862965001168	ABC transporter signature motif; other site
862965001169	Walker B; other site
862965001170	D-loop; other site
862965001171	H-loop/switch region; other site
862965001172	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
862965001173	TPR motif; other site
862965001174	binding surface
862965001175	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
862965001176	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
862965001177	active site
862965001178	substrate-binding site [chemical binding]; other site
862965001179	metal-binding site [ion binding]
862965001180	ATP binding site [chemical binding]; other site
862965001181	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
862965001182	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
862965001183	Ligand Binding Site [chemical binding]; other site
862965001184	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
862965001185	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
862965001186	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
862965001187	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
862965001188	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
862965001189	Glutamate binding site [chemical binding]; other site
862965001190	NAD binding site [chemical binding]; other site
862965001191	catalytic residues [active]
862965001192	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
862965001193	Na binding site [ion binding]; other site
862965001194	Integrase core domain; Region: rve_2; pfam13333
862965001195	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
862965001196	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
862965001197	dimerization interface [polypeptide binding]; other site
862965001198	domain crossover interface; other site
862965001199	redox-dependent activation switch; other site
862965001200	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
862965001201	trimer interface [polypeptide binding]; other site
862965001202	eyelet of channel; other site
862965001203	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
862965001204	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
862965001205	putative active site [active]
862965001206	EamA-like transporter family; Region: EamA; pfam00892
862965001207	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
862965001208	EamA-like transporter family; Region: EamA; pfam00892
862965001209	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
862965001210	proximal heme binding site [chemical binding]; other site
862965001211	YcxB-like protein; Region: YcxB; pfam14317
862965001212	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
862965001213	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
862965001214	putative active site [active]
862965001215	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
862965001216	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
862965001217	NADP binding site [chemical binding]; other site
862965001218	homopentamer interface [polypeptide binding]; other site
862965001219	substrate binding site [chemical binding]; other site
862965001220	active site
862965001221	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
862965001222	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
862965001223	catalytic residues [active]
862965001224	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
862965001225	intersubunit interface [polypeptide binding]; other site
862965001226	active site
862965001227	catalytic residue [active]
862965001228	phosphoglycolate phosphatase; Provisional; Region: PRK13222
862965001229	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
862965001230	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862965001231	motif II; other site
862965001232	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
862965001233	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
862965001234	substrate binding site [chemical binding]; other site
862965001235	hexamer interface [polypeptide binding]; other site
862965001236	metal binding site [ion binding]; metal-binding site
862965001237	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
862965001238	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
862965001239	active site
862965001240	metal binding site [ion binding]; metal-binding site
862965001241	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
862965001242	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
862965001243	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
862965001244	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862965001245	FeS/SAM binding site; other site
862965001246	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
862965001247	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
862965001248	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
862965001249	ligand binding site [chemical binding]; other site
862965001250	flexible hinge region; other site
862965001251	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
862965001252	Sulfatase; Region: Sulfatase; cl17466
862965001253	putative transporter; Provisional; Region: PRK10484
862965001254	uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328
862965001255	Na binding site [ion binding]; other site
862965001256	Predicted permeases [General function prediction only]; Region: COG0730
862965001257	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
862965001258	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
862965001259	homodimer interface [polypeptide binding]; other site
862965001260	metal binding site [ion binding]; metal-binding site
862965001261	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
862965001262	homodimer interface [polypeptide binding]; other site
862965001263	active site
862965001264	putative chemical substrate binding site [chemical binding]; other site
862965001265	metal binding site [ion binding]; metal-binding site
862965001266	portal vertex protein; Provisional; Region: Q; PHA02536
862965001267	Phage portal protein; Region: Phage_portal; pfam04860
862965001268	terminase ATPase subunit; Provisional; Region: P; PHA02535
862965001269	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
862965001270	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
862965001271	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
862965001272	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
862965001273	terminase endonuclease subunit; Provisional; Region: M; PHA02537
862965001274	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
862965001275	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
862965001276	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
862965001277	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
862965001278	catalytic residues [active]
862965001279	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
862965001280	phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419
862965001281	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
862965001282	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
862965001283	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
862965001284	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
862965001285	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
862965001286	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
862965001287	Baseplate J-like protein; Region: Baseplate_J; cl01294
862965001288	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
862965001289	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
862965001290	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
862965001291	major tail sheath protein; Provisional; Region: FI; PHA02560
862965001292	Phage tail tube protein FII; Region: Phage_tube; cl01390
862965001293	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
862965001294	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
862965001295	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
862965001296	tail protein; Provisional; Region: D; PHA02561
862965001297	WYL domain; Region: WYL; pfam13280
862965001298	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
862965001299	Dimer interface [polypeptide binding]; other site
862965001300	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
862965001301	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
862965001302	non-specific DNA binding site [nucleotide binding]; other site
862965001303	salt bridge; other site
862965001304	sequence-specific DNA binding site [nucleotide binding]; other site
862965001305	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
862965001306	Catalytic site [active]
862965001307	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
862965001308	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
862965001309	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540
862965001310	putative metal binding site [ion binding]; other site
862965001311	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
862965001312	active site
862965001313	DNA binding site [nucleotide binding]
862965001314	Int/Topo IB signature motif; other site
862965001315	Flavodoxin domain; Region: Flavodoxin_5; cl17428
862965001316	Cation transport protein; Region: TrkH; cl17365
862965001317	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
862965001318	hypothetical protein; Provisional; Region: PRK11568
862965001319	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
862965001320	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
862965001321	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
862965001322	CPxP  motif; other site
862965001323	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
862965001324	DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cl02442
862965001325	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
862965001326	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
862965001327	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
862965001328	G1 box; other site
862965001329	putative GEF interaction site [polypeptide binding]; other site
862965001330	GTP/Mg2+ binding site [chemical binding]; other site
862965001331	Switch I region; other site
862965001332	G2 box; other site
862965001333	G3 box; other site
862965001334	Switch II region; other site
862965001335	G4 box; other site
862965001336	G5 box; other site
862965001337	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
862965001338	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
862965001339	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
862965001340	DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cl02442
862965001341	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
862965001342	selenocysteine synthase; Provisional; Region: PRK04311
862965001343	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
862965001344	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
862965001345	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
862965001346	catalytic residue [active]
862965001347	elongation factor Tu; Reviewed; Region: PRK00049
862965001348	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
862965001349	G1 box; other site
862965001350	GEF interaction site [polypeptide binding]; other site
862965001351	GTP/Mg2+ binding site [chemical binding]; other site
862965001352	Switch I region; other site
862965001353	G2 box; other site
862965001354	G3 box; other site
862965001355	Switch II region; other site
862965001356	G4 box; other site
862965001357	G5 box; other site
862965001358	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
862965001359	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
862965001360	Antibiotic Binding Site [chemical binding]; other site
862965001361	elongation factor G; Reviewed; Region: PRK00007
862965001362	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
862965001363	G1 box; other site
862965001364	putative GEF interaction site [polypeptide binding]; other site
862965001365	GTP/Mg2+ binding site [chemical binding]; other site
862965001366	Switch I region; other site
862965001367	G2 box; other site
862965001368	G3 box; other site
862965001369	Switch II region; other site
862965001370	G4 box; other site
862965001371	G5 box; other site
862965001372	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
862965001373	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
862965001374	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
862965001375	30S ribosomal protein S7; Validated; Region: PRK05302
862965001376	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
862965001377	S17 interaction site [polypeptide binding]; other site
862965001378	S8 interaction site; other site
862965001379	16S rRNA interaction site [nucleotide binding]; other site
862965001380	streptomycin interaction site [chemical binding]; other site
862965001381	23S rRNA interaction site [nucleotide binding]; other site
862965001382	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
862965001383	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
862965001384	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
862965001385	putative ion selectivity filter; other site
862965001386	putative pore gating glutamate residue; other site
862965001387	putative H+/Cl- coupling transport residue; other site
862965001388	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
862965001389	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
862965001390	FMN binding site [chemical binding]; other site
862965001391	active site
862965001392	catalytic residues [active]
862965001393	substrate binding site [chemical binding]; other site
862965001394	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK01792
862965001395	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
862965001396	nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526
862965001397	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
862965001398	active site
862965001399	(T/H)XGH motif; other site
862965001400	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
862965001401	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
862965001402	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
862965001403	active site
862965001404	metal binding site [ion binding]; metal-binding site
862965001405	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
862965001406	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
862965001407	Part of AAA domain; Region: AAA_19; pfam13245
862965001408	Family description; Region: UvrD_C_2; pfam13538
862965001409	Protein of unknown function (DUF1375); Region: DUF1375; cl11456
862965001410	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
862965001411	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
862965001412	active site
862965001413	(T/H)XGH motif; other site
862965001414	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
862965001415	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
862965001416	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
862965001417	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
862965001418	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
862965001419	putative metal binding site; other site
862965001421	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
862965001422	NodB motif; other site
862965001423	putative active site [active]
862965001424	putative catalytic site [active]
862965001425	Zn binding site [ion binding]; other site
862965001426	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
862965001427	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059
862965001428	Peptidase family M23; Region: Peptidase_M23; pfam01551
862965001429	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
862965001430	catalytic core [active]
862965001431	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
862965001432	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
862965001433	pseudouridine synthase; Region: TIGR00093
862965001434	probable active site [active]
862965001435	ketol-acid reductoisomerase; Validated; Region: PRK05225
862965001436	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
862965001437	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
862965001438	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
862965001439	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
862965001440	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
862965001441	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
862965001442	putative dimerization interface [polypeptide binding]; other site
862965001443	rarD protein; Region: rarD; TIGR00688
862965001444	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
862965001445	active site residue [active]
862965001446	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
862965001447	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
862965001448	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
862965001449	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862965001450	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965001451	Walker A/P-loop; other site
862965001452	ATP binding site [chemical binding]; other site
862965001453	Q-loop/lid; other site
862965001454	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862965001455	ABC transporter signature motif; other site
862965001456	Walker B; other site
862965001457	D-loop; other site
862965001458	ABC transporter; Region: ABC_tran_2; pfam12848
862965001459	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862965001460	Fungal protein of unknown function (DUF1742); Region: DUF1742; pfam08432
862965001461	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
862965001462	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
862965001463	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
862965001464	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
862965001465	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
862965001466	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
862965001467	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
862965001468	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
862965001469	shikimate binding site; other site
862965001470	NAD(P) binding site [chemical binding]; other site
862965001471	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
862965001472	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
862965001473	OstA-like protein; Region: OstA; pfam03968
862965001474	Organic solvent tolerance protein; Region: OstA_C; pfam04453
862965001475	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
862965001476	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
862965001477	active site
862965001478	Int/Topo IB signature motif; other site
862965001479	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
862965001480	triosephosphate isomerase; Provisional; Region: PRK14567
862965001481	substrate binding site [chemical binding]; other site
862965001482	dimer interface [polypeptide binding]; other site
862965001483	catalytic triad [active]
862965001484	transcriptional regulator NarP; Provisional; Region: PRK10403
862965001485	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862965001486	active site
862965001487	phosphorylation site [posttranslational modification]
862965001488	intermolecular recognition site; other site
862965001489	dimerization interface [polypeptide binding]; other site
862965001490	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
862965001491	DNA binding residues [nucleotide binding]
862965001492	dimerization interface [polypeptide binding]; other site
862965001493	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
862965001494	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
862965001495	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
862965001496	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
862965001497	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
862965001498	domain interfaces; other site
862965001499	active site
862965001500	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
862965001501	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
862965001502	active site
862965001503	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
862965001504	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
862965001505	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
862965001506	HemY protein N-terminus; Region: HemY_N; pfam07219
862965001507	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965001508	dimer interface [polypeptide binding]; other site
862965001509	conserved gate region; other site
862965001510	putative PBP binding loops; other site
862965001511	ABC-ATPase subunit interface; other site
862965001512	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
862965001513	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965001514	dimer interface [polypeptide binding]; other site
862965001515	conserved gate region; other site
862965001516	putative PBP binding loops; other site
862965001517	ABC-ATPase subunit interface; other site
862965001518	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
862965001519	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
862965001520	Walker A/P-loop; other site
862965001521	ATP binding site [chemical binding]; other site
862965001522	Q-loop/lid; other site
862965001523	ABC transporter signature motif; other site
862965001524	Walker B; other site
862965001525	D-loop; other site
862965001526	H-loop/switch region; other site
862965001527	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
862965001528	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
862965001529	substrate binding pocket [chemical binding]; other site
862965001530	membrane-bound complex binding site; other site
862965001531	hinge residues; other site
862965001532	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
862965001533	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
862965001534	intersubunit interface [polypeptide binding]; other site
862965001535	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013
862965001536	Domain of unknown function (DUF4424); Region: DUF4424; pfam14415
862965001537	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
862965001538	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
862965001539	putative deacylase active site [active]
862965001540	DsrH like protein; Region: DsrH; cl17347
862965001541	sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010
862965001542	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
862965001543	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
862965001544	YheO-like PAS domain; Region: PAS_6; pfam08348
862965001545	HTH domain; Region: HTH_22; pfam13309
862965001546	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
862965001547	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
862965001548	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
862965001549	hypothetical protein; Provisional; Region: PRK02119
862965001550	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
862965001551	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965001552	Walker A/P-loop; other site
862965001553	ATP binding site [chemical binding]; other site
862965001554	Q-loop/lid; other site
862965001555	ABC transporter signature motif; other site
862965001556	Walker B; other site
862965001557	D-loop; other site
862965001558	H-loop/switch region; other site
862965001559	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
862965001560	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965001561	dimer interface [polypeptide binding]; other site
862965001562	conserved gate region; other site
862965001563	putative PBP binding loops; other site
862965001564	ABC-ATPase subunit interface; other site
862965001565	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
862965001566	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965001567	dimer interface [polypeptide binding]; other site
862965001568	conserved gate region; other site
862965001569	putative PBP binding loops; other site
862965001570	ABC-ATPase subunit interface; other site
862965001571	hypothetical protein; Provisional; Region: PRK11622
862965001572	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
862965001573	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
862965001574	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
862965001575	transmembrane helices; other site
862965001576	putative sialic acid transporter; Provisional; Region: PRK12307
862965001577	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862965001578	putative substrate translocation pore; other site
862965001579	Transcriptional regulators [Transcription]; Region: FadR; COG2186
862965001580	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
862965001581	DNA-binding site [nucleotide binding]; DNA binding site
862965001582	FCD domain; Region: FCD; pfam07729
862965001583	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
862965001584	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
862965001585	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
862965001586	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
862965001587	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
862965001588	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
862965001589	hypothetical protein; Provisional; Region: PRK10215
862965001590	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
862965001591	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
862965001592	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
862965001593	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
862965001594	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
862965001595	peptide binding site [polypeptide binding]; other site
862965001596	putative transporter; Provisional; Region: PRK10504
862965001597	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862965001598	putative substrate translocation pore; other site
862965001599	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862965001600	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
862965001601	Walker A motif; other site
862965001602	anti-sigma E factor; Provisional; Region: rseB; PRK09455
862965001603	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
862965001604	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
862965001605	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
862965001606	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
862965001607	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
862965001608	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
862965001609	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
862965001610	DNA binding residues [nucleotide binding]
862965001611	Uncharacterized conserved protein [Function unknown]; Region: COG2938
862965001612	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
862965001613	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
862965001614	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
862965001615	active site
862965001616	P-loop; other site
862965001617	phosphorylation site [posttranslational modification]
862965001618	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
862965001619	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
862965001620	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
862965001621	putative substrate binding site [chemical binding]; other site
862965001622	putative ATP binding site [chemical binding]; other site
862965001623	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK13779
862965001624	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
862965001625	active site
862965001626	phosphorylation site [posttranslational modification]
862965001627	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
862965001628	dimerization domain swap beta strand [polypeptide binding]; other site
862965001629	regulatory protein interface [polypeptide binding]; other site
862965001630	active site
862965001631	regulatory phosphorylation site [posttranslational modification]; other site
862965001632	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
862965001633	regulatory protein interface [polypeptide binding]; other site
862965001634	active site
862965001635	regulatory phosphorylation site [posttranslational modification]; other site
862965001636	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
862965001637	Domain of unknown function DUF21; Region: DUF21; pfam01595
862965001638	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
862965001639	Transporter associated domain; Region: CorC_HlyC; smart01091
862965001640	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
862965001641	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
862965001642	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
862965001643	active site
862965001644	DNA polymerase III subunit delta'; Validated; Region: PRK06871
862965001645	DNA polymerase III subunit delta'; Validated; Region: PRK08485
862965001646	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
862965001647	thymidylate kinase; Validated; Region: tmk; PRK00698
862965001648	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
862965001649	TMP-binding site; other site
862965001650	ATP-binding site [chemical binding]; other site
862965001651	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
862965001652	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
862965001653	dimerization interface [polypeptide binding]; other site
862965001654	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
862965001655	SurA N-terminal domain; Region: SurA_N; pfam09312
862965001656	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
862965001657	Pleckstrin homology-like domain; Region: PH-like; cl17171
862965001658	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
862965001659	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862965001660	active site
862965001661	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
862965001662	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
862965001663	putative active site [active]
862965001664	putative PHP Thumb interface [polypeptide binding]; other site
862965001665	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
862965001666	generic binding surface II; other site
862965001667	generic binding surface I; other site
862965001669	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862965001670	active site
862965001671	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
862965001672	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
862965001673	metal binding site [ion binding]; metal-binding site
862965001674	dimer interface [polypeptide binding]; other site
862965001675	heat shock protein HtpX; Provisional; Region: PRK05457
862965001676	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
862965001677	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
862965001678	GTP binding site; other site
862965001679	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
862965001680	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
862965001681	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
862965001682	catalytic residues [active]
862965001683	hinge region; other site
862965001684	alpha helical domain; other site
862965001685	hypothetical protein; Provisional; Region: PRK11027
862965001686	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
862965001687	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862965001688	S-adenosylmethionine binding site [chemical binding]; other site
862965001689	Putative SAM-dependent methyltransferase; Region: SAM_MT; pfam04445
862965001690	Positive regulator of sigma E activity [Signal transduction mechanisms]; Region: RseC; COG3086
862965001691	putrescine transporter; Provisional; Region: potE; PRK10655
862965001692	ornithine decarboxylase; Provisional; Region: PRK13578
862965001693	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
862965001694	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
862965001695	homodimer interface [polypeptide binding]; other site
862965001696	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862965001697	catalytic residue [active]
862965001698	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
862965001699	ornithine carbamoyltransferase; Provisional; Region: PRK01713
862965001700	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
862965001701	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
862965001702	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
862965001703	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
862965001704	active site
862965001705	metal binding site [ion binding]; metal-binding site
862965001706	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
862965001707	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
862965001708	Na2 binding site [ion binding]; other site
862965001709	putative substrate binding site 1 [chemical binding]; other site
862965001710	Na binding site 1 [ion binding]; other site
862965001711	putative substrate binding site 2 [chemical binding]; other site
862965001712	Protein of unknown function (DUF533); Region: DUF533; pfam04391
862965001713	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
862965001714	putative metal binding site [ion binding]; other site
862965001715	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
862965001716	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
862965001717	PYR/PP interface [polypeptide binding]; other site
862965001718	dimer interface [polypeptide binding]; other site
862965001719	TPP binding site [chemical binding]; other site
862965001720	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
862965001721	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
862965001722	TPP-binding site [chemical binding]; other site
862965001723	dimer interface [polypeptide binding]; other site
862965001724	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
862965001725	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
862965001726	threonine dehydratase; Reviewed; Region: PRK09224
862965001727	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
862965001728	tetramer interface [polypeptide binding]; other site
862965001729	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862965001730	catalytic residue [active]
862965001731	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
862965001732	putative Ile/Val binding site [chemical binding]; other site
862965001733	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
862965001734	putative Ile/Val binding site [chemical binding]; other site
862965001735	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
862965001736	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
862965001737	gamma subunit interface [polypeptide binding]; other site
862965001738	epsilon subunit interface [polypeptide binding]; other site
862965001739	LBP interface [polypeptide binding]; other site
862965001740	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
862965001741	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
862965001742	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
862965001743	alpha subunit interaction interface [polypeptide binding]; other site
862965001744	Walker A motif; other site
862965001745	ATP binding site [chemical binding]; other site
862965001746	Walker B motif; other site
862965001747	inhibitor binding site; inhibition site
862965001748	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
862965001749	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
862965001750	core domain interface [polypeptide binding]; other site
862965001751	delta subunit interface [polypeptide binding]; other site
862965001752	epsilon subunit interface [polypeptide binding]; other site
862965001753	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
862965001754	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
862965001755	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
862965001756	beta subunit interaction interface [polypeptide binding]; other site
862965001757	Walker A motif; other site
862965001758	ATP binding site [chemical binding]; other site
862965001759	Walker B motif; other site
862965001760	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
862965001761	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
862965001762	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
862965001763	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
862965001764	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
862965001765	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
862965001766	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
862965001767	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
862965001768	F0F1 ATP synthase subunit I; Validated; Region: PRK06099
862965001769	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
862965001770	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
862965001771	Predicted transcriptional regulators [Transcription]; Region: COG1733
862965001772	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
862965001773	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
862965001774	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
862965001775	NADP binding site [chemical binding]; other site
862965001776	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
862965001777	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
862965001778	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
862965001779	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
862965001780	FMN-binding protein MioC; Provisional; Region: PRK09004
862965001781	Protein of unknown function (DUF904); Region: DUF904; pfam06005
862965001782	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
862965001783	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
862965001784	putative active site [active]
862965001785	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
862965001786	MutS domain I; Region: MutS_I; pfam01624
862965001787	MutS domain II; Region: MutS_II; pfam05188
862965001788	MutS domain III; Region: MutS_III; pfam05192
862965001789	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
862965001790	Walker A/P-loop; other site
862965001791	ATP binding site [chemical binding]; other site
862965001792	Q-loop/lid; other site
862965001793	ABC transporter signature motif; other site
862965001794	Walker B; other site
862965001795	D-loop; other site
862965001796	H-loop/switch region; other site
862965001797	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
862965001798	MgtC family; Region: MgtC; pfam02308
862965001799	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
862965001800	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
862965001801	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862965001802	FeS/SAM binding site; other site
862965001803	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
862965001804	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
862965001805	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
862965001806	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
862965001807	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
862965001808	tyrosine phenol-lyase; Provisional; Region: PRK13237
862965001809	Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617
862965001810	substrate binding site [chemical binding]; other site
862965001811	tetramer interface [polypeptide binding]; other site
862965001812	catalytic residue [active]
862965001813	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
862965001814	aromatic amino acid transport protein; Region: araaP; TIGR00837
862965001815	YheO-like PAS domain; Region: PAS_6; pfam08348
862965001816	HTH domain; Region: HTH_22; pfam13309
862965001817	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
862965001818	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
862965001819	ATP-grasp domain; Region: ATP-grasp; pfam02222
862965001820	S-ribosylhomocysteinase; Provisional; Region: PRK02260
862965001821	Predicted membrane protein [Function unknown]; Region: COG1238
862965001822	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
862965001823	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862965001824	motif II; other site
862965001825	exopolyphosphatase; Provisional; Region: PRK10854
862965001826	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
862965001827	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
862965001828	Family of unknown function (DUF490); Region: DUF490; pfam04357
862965001829	Family of unknown function (DUF490); Region: DUF490; pfam04357
862965001830	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
862965001831	Surface antigen; Region: Bac_surface_Ag; pfam01103
862965001832	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
862965001833	putative active site [active]
862965001834	dimerization interface [polypeptide binding]; other site
862965001835	putative tRNAtyr binding site [nucleotide binding]; other site
862965001836	hypothetical protein; Reviewed; Region: PRK01637
862965001837	hypothetical protein; Provisional; Region: PRK01752
862965001838	SEC-C motif; Region: SEC-C; pfam02810
862965001839	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
862965001840	MOSC domain; Region: MOSC; pfam03473
862965001841	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
862965001842	Domain of unknown function DUF87; Region: DUF87; pfam01935
862965001843	uridine phosphorylase; Provisional; Region: PRK11178
862965001844	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
862965001845	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
862965001846	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
862965001847	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
862965001848	shikimate binding site; other site
862965001849	NAD(P) binding site [chemical binding]; other site
862965001850	serine acetyltransferase; Provisional; Region: cysE; PRK11132
862965001851	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
862965001852	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
862965001853	trimer interface [polypeptide binding]; other site
862965001854	active site
862965001855	substrate binding site [chemical binding]; other site
862965001856	CoA binding site [chemical binding]; other site
862965001857	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
862965001858	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
862965001859	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
862965001860	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
862965001861	SecA binding site; other site
862965001862	Preprotein binding site; other site
862965001863	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
862965001864	active site residue [active]
862965001865	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
862965001866	active site
862965001867	homotetramer interface [polypeptide binding]; other site
862965001868	homodimer interface [polypeptide binding]; other site
862965001869	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
862965001870	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
862965001871	Predicted membrane protein [Function unknown]; Region: COG1288
862965001872	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
862965001874	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
862965001875	Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298
862965001876	Protein of unknown function (DUF560); Region: DUF560; pfam04575
862965001877	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862965001878	putative substrate translocation pore; other site
862965001879	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
862965001880	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
862965001881	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965001882	Walker A/P-loop; other site
862965001883	ATP binding site [chemical binding]; other site
862965001884	Q-loop/lid; other site
862965001885	ABC transporter signature motif; other site
862965001886	Walker B; other site
862965001887	D-loop; other site
862965001888	H-loop/switch region; other site
862965001889	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
862965001890	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862965001891	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965001892	Walker A/P-loop; other site
862965001893	ATP binding site [chemical binding]; other site
862965001894	Q-loop/lid; other site
862965001895	ABC transporter signature motif; other site
862965001896	Walker B; other site
862965001897	D-loop; other site
862965001898	H-loop/switch region; other site
862965001899	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
862965001900	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
862965001901	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
862965001902	Protein of unknown function (DUF535); Region: DUF535; cl01128
862965001903	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
862965001904	Found in ATP-dependent protease La (LON); Region: LON; smart00464
862965001905	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862965001906	Walker A motif; other site
862965001907	ATP binding site [chemical binding]; other site
862965001908	Walker B motif; other site
862965001909	arginine finger; other site
862965001910	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
862965001911	HemN family oxidoreductase; Provisional; Region: PRK05660
862965001912	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862965001913	FeS/SAM binding site; other site
862965001914	HemN C-terminal domain; Region: HemN_C; pfam06969
862965001915	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
862965001916	tetramer (dimer of dimers) interface [polypeptide binding]; other site
862965001917	active site
862965001918	dimer interface [polypeptide binding]; other site
862965001919	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
862965001920	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
862965001921	ligand binding site [chemical binding]; other site
862965001922	NAD binding site [chemical binding]; other site
862965001923	tetramer interface [polypeptide binding]; other site
862965001924	catalytic site [active]
862965001925	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
862965001926	L-serine binding site [chemical binding]; other site
862965001927	ACT domain interface; other site
862965001928	hydrogenase 2-specific chaperone; Provisional; Region: PRK10465
862965001929	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
862965001930	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
862965001931	putative substrate-binding site; other site
862965001932	nickel binding site [ion binding]; other site
862965001933	hydrogenase 2 large subunit; Provisional; Region: PRK10467
862965001934	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
862965001935	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
862965001936	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
862965001937	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
862965001938	4Fe-4S binding domain; Region: Fer4_6; pfam12837
862965001939	hydrogenase 2 small subunit; Provisional; Region: PRK10468
862965001940	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
862965001941	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
862965001942	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
862965001943	Protein of unknown function (DUF3137); Region: DUF3137; pfam11335
862965001944	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
862965001945	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862965001946	ATP binding site [chemical binding]; other site
862965001947	Mg2+ binding site [ion binding]; other site
862965001948	G-X-G motif; other site
862965001949	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
862965001950	anchoring element; other site
862965001951	dimer interface [polypeptide binding]; other site
862965001952	ATP binding site [chemical binding]; other site
862965001953	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
862965001954	active site
862965001955	putative metal-binding site [ion binding]; other site
862965001956	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
862965001957	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
862965001958	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862965001959	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965001960	Walker A/P-loop; other site
862965001961	ATP binding site [chemical binding]; other site
862965001962	Q-loop/lid; other site
862965001963	ABC transporter signature motif; other site
862965001964	Walker B; other site
862965001965	D-loop; other site
862965001966	H-loop/switch region; other site
862965001967	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
862965001968	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862965001969	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965001970	Walker A/P-loop; other site
862965001971	ATP binding site [chemical binding]; other site
862965001972	Q-loop/lid; other site
862965001973	ABC transporter signature motif; other site
862965001974	Walker B; other site
862965001975	D-loop; other site
862965001976	H-loop/switch region; other site
862965001977	pantothenate kinase; Provisional; Region: PRK05439
862965001978	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
862965001979	ATP-binding site [chemical binding]; other site
862965001980	CoA-binding site [chemical binding]; other site
862965001981	Mg2+-binding site [ion binding]; other site
862965001982	elongation factor Tu; Reviewed; Region: PRK00049
862965001983	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
862965001984	G1 box; other site
862965001985	GEF interaction site [polypeptide binding]; other site
862965001986	GTP/Mg2+ binding site [chemical binding]; other site
862965001987	Switch I region; other site
862965001988	G2 box; other site
862965001989	G3 box; other site
862965001990	Switch II region; other site
862965001991	G4 box; other site
862965001992	G5 box; other site
862965001993	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
862965001994	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
862965001995	Antibiotic Binding Site [chemical binding]; other site
862965001996	putative hydrolase; Provisional; Region: PRK10976
862965001997	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862965001998	active site
862965001999	motif I; other site
862965002000	motif II; other site
862965002001	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
862965002002	chromosome condensation membrane protein; Provisional; Region: PRK14196
862965002003	recombination regulator RecX; Reviewed; Region: recX; PRK00117
862965002004	recombinase A; Provisional; Region: recA; PRK09354
862965002005	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
862965002006	hexamer interface [polypeptide binding]; other site
862965002007	Walker A motif; other site
862965002008	ATP binding site [chemical binding]; other site
862965002009	Walker B motif; other site
862965002010	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
862965002011	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
862965002012	active site
862965002013	nucleophile elbow; other site
862965002014	TfoX N-terminal domain; Region: TfoX_N; pfam04993
862965002015	TfoX C-terminal domain; Region: TfoX_C; pfam04994
862965002016	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
862965002017	active site
862965002018	catalytic residues [active]
862965002019	metal binding site [ion binding]; metal-binding site
862965002020	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
862965002021	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
862965002022	putative active site [active]
862965002023	substrate binding site [chemical binding]; other site
862965002024	putative cosubstrate binding site; other site
862965002025	catalytic site [active]
862965002026	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
862965002027	substrate binding site [chemical binding]; other site
862965002028	16S rRNA methyltransferase B; Provisional; Region: PRK10901
862965002029	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
862965002030	putative RNA binding site [nucleotide binding]; other site
862965002031	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862965002032	S-adenosylmethionine binding site [chemical binding]; other site
862965002033	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
862965002034	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
862965002035	active site
862965002036	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
862965002037	TrkA-N domain; Region: TrkA_N; pfam02254
862965002038	TrkA-C domain; Region: TrkA_C; pfam02080
862965002039	TrkA-N domain; Region: TrkA_N; pfam02254
862965002040	TrkA-C domain; Region: TrkA_C; pfam02080
862965002041	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
862965002042	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
862965002043	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
862965002044	homotrimer interaction site [polypeptide binding]; other site
862965002045	zinc binding site [ion binding]; other site
862965002046	CDP-binding sites; other site
862965002047	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
862965002048	substrate binding site; other site
862965002049	dimer interface; other site
862965002050	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
862965002051	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
862965002052	Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503
862965002053	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
862965002054	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
862965002055	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
862965002056	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
862965002057	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
862965002058	dimerization interface [polypeptide binding]; other site
862965002059	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
862965002060	catalytic triad [active]
862965002061	dimer interface [polypeptide binding]; other site
862965002062	Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029
862965002063	GSH binding site [chemical binding]; other site
862965002064	catalytic residues [active]
862965002065	Rhomboid family; Region: Rhomboid; pfam01694
862965002066	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
862965002067	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
862965002068	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
862965002069	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
862965002070	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
862965002071	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862965002072	S-adenosylmethionine binding site [chemical binding]; other site
862965002073	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
862965002074	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
862965002075	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
862965002076	P loop; other site
862965002077	GTP binding site [chemical binding]; other site
862965002078	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
862965002079	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965002080	Walker A/P-loop; other site
862965002081	ATP binding site [chemical binding]; other site
862965002082	Q-loop/lid; other site
862965002083	ABC transporter signature motif; other site
862965002084	Walker B; other site
862965002085	D-loop; other site
862965002086	H-loop/switch region; other site
862965002087	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
862965002088	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
862965002089	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
862965002090	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
862965002091	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
862965002092	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
862965002093	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
862965002094	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
862965002095	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
862965002096	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
862965002097	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
862965002098	protein-rRNA interface [nucleotide binding]; other site
862965002099	putative translocon binding site; other site
862965002100	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
862965002101	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
862965002102	G-X-X-G motif; other site
862965002103	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
862965002104	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
862965002105	23S rRNA interface [nucleotide binding]; other site
862965002106	5S rRNA interface [nucleotide binding]; other site
862965002107	putative antibiotic binding site [chemical binding]; other site
862965002108	L25 interface [polypeptide binding]; other site
862965002109	L27 interface [polypeptide binding]; other site
862965002110	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
862965002111	23S rRNA interface [nucleotide binding]; other site
862965002112	putative translocon interaction site; other site
862965002113	signal recognition particle (SRP54) interaction site; other site
862965002114	L23 interface [polypeptide binding]; other site
862965002115	trigger factor interaction site; other site
862965002116	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
862965002117	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
862965002118	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
862965002119	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
862965002120	RNA binding site [nucleotide binding]; other site
862965002121	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
862965002122	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
862965002123	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
862965002124	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
862965002125	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
862965002126	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
862965002127	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
862965002128	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
862965002129	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
862965002130	5S rRNA interface [nucleotide binding]; other site
862965002131	L27 interface [polypeptide binding]; other site
862965002132	23S rRNA interface [nucleotide binding]; other site
862965002133	L5 interface [polypeptide binding]; other site
862965002134	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
862965002135	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
862965002136	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
862965002137	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
862965002138	23S rRNA binding site [nucleotide binding]; other site
862965002139	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
862965002140	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
862965002141	SecY translocase; Region: SecY; pfam00344
862965002142	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
862965002143	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
862965002144	30S ribosomal protein S13; Region: bact_S13; TIGR03631
862965002145	30S ribosomal protein S11; Validated; Region: PRK05309
862965002146	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
862965002147	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
862965002148	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
862965002149	RNA binding surface [nucleotide binding]; other site
862965002150	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
862965002151	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
862965002152	alphaNTD homodimer interface [polypeptide binding]; other site
862965002153	alphaNTD - beta interaction site [polypeptide binding]; other site
862965002154	alphaNTD - beta' interaction site [polypeptide binding]; other site
862965002155	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
862965002156	Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203
862965002157	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
862965002158	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
862965002159	active site
862965002160	ATP-dependent helicase HepA; Validated; Region: PRK04914
862965002161	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
862965002162	ATP binding site [chemical binding]; other site
862965002163	putative Mg++ binding site [ion binding]; other site
862965002164	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862965002165	nucleotide binding region [chemical binding]; other site
862965002166	ATP-binding site [chemical binding]; other site
862965002167	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
862965002168	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
862965002169	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862965002170	S-adenosylmethionine binding site [chemical binding]; other site
862965002171	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
862965002172	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
862965002173	ATP binding site [chemical binding]; other site
862965002174	Mg++ binding site [ion binding]; other site
862965002175	motif III; other site
862965002176	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862965002177	nucleotide binding region [chemical binding]; other site
862965002178	ATP-binding site [chemical binding]; other site
862965002179	Domain of unknown function (DUF4298); Region: DUF4298; pfam14131
862965002180	6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362
862965002181	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
862965002182	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
862965002183	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
862965002184	GIY-YIG motif/motif A; other site
862965002185	active site
862965002186	catalytic site [active]
862965002187	metal binding site [ion binding]; metal-binding site
862965002188	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862965002189	Coenzyme A binding pocket [chemical binding]; other site
862965002190	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
862965002191	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
862965002192	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
862965002193	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
862965002194	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
862965002195	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
862965002196	putative active site [active]
862965002197	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
862965002198	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
862965002199	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
862965002200	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
862965002201	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
862965002202	active site
862965002203	Predicted membrane protein [Function unknown]; Region: COG1297
862965002204	putative oligopeptide transporter, OPT family; Region: TIGR00733
862965002205	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
862965002206	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
862965002207	dimer interface [polypeptide binding]; other site
862965002208	ADP-ribose binding site [chemical binding]; other site
862965002209	active site
862965002210	nudix motif; other site
862965002211	metal binding site [ion binding]; metal-binding site
862965002212	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
862965002213	RNA binding surface [nucleotide binding]; other site
862965002214	hypothetical protein; Provisional; Region: PRK05208
862965002215	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
862965002216	RmuC family; Region: RmuC; pfam02646
862965002217	acid phosphatase/phosphotransferase; Provisional; Region: aphA; PRK11009
862965002218	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
862965002219	HslU subunit interaction site [polypeptide binding]; other site
862965002220	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
862965002221	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862965002222	Walker A motif; other site
862965002223	ATP binding site [chemical binding]; other site
862965002224	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862965002225	Walker B motif; other site
862965002226	arginine finger; other site
862965002227	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
862965002228	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737
862965002229	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
862965002230	Protein of unknown function (DUF541); Region: SIMPL; cl01077
862965002231	RNase E inhibitor protein; Provisional; Region: PRK11191
862965002232	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
862965002233	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
862965002234	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
862965002235	Permutation of conserved domain; other site
862965002236	active site
862965002237	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
862965002238	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
862965002239	Predicted membrane protein [Function unknown]; Region: COG1238
862965002240	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
862965002241	Peptidase family M23; Region: Peptidase_M23; pfam01551
862965002242	prolyl-tRNA synthetase; Provisional; Region: PRK09194
862965002243	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
862965002244	dimer interface [polypeptide binding]; other site
862965002245	motif 1; other site
862965002246	active site
862965002247	motif 2; other site
862965002248	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
862965002249	putative deacylase active site [active]
862965002250	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
862965002251	active site
862965002252	motif 3; other site
862965002253	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
862965002254	anticodon binding site; other site
862965002255	Protein of unknown function (DUF560); Region: DUF560; pfam04575
862965002256	Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298
862965002257	Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298
862965002258	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
862965002259	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862965002260	S-adenosylmethionine binding site [chemical binding]; other site
862965002261	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
862965002262	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
862965002263	dimerization interface [polypeptide binding]; other site
862965002264	ATP binding site [chemical binding]; other site
862965002265	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
862965002266	dimerization interface [polypeptide binding]; other site
862965002267	ATP binding site [chemical binding]; other site
862965002268	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
862965002269	putative active site [active]
862965002270	catalytic triad [active]
862965002271	Predicted membrane protein [Function unknown]; Region: COG3059
862965002272	Protein of unknown function (DUF541); Region: SIMPL; cl01077
862965002273	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
862965002274	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
862965002275	active site
862965002276	catalytic site [active]
862965002277	metal binding site [ion binding]; metal-binding site
862965002278	glycerol-3-phosphate transporter; Region: glpT; TIGR00712
862965002279	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862965002280	putative substrate translocation pore; other site
862965002281	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
862965002282	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
862965002283	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
862965002284	glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378
862965002285	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
862965002286	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
862965002287	Cysteine-rich domain; Region: CCG; pfam02754
862965002288	Cysteine-rich domain; Region: CCG; pfam02754
862965002289	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
862965002290	dimer interface [polypeptide binding]; other site
862965002291	active site
862965002292	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
862965002293	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
862965002294	putative DNA binding site [nucleotide binding]; other site
862965002295	dimerization interface [polypeptide binding]; other site
862965002296	putative Zn2+ binding site [ion binding]; other site
862965002297	AsnC family; Region: AsnC_trans_reg; pfam01037
862965002298	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
862965002299	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
862965002300	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
862965002301	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
862965002302	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
862965002303	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
862965002304	adenylosuccinate lyase; Provisional; Region: PRK09285
862965002305	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
862965002306	tetramer interface [polypeptide binding]; other site
862965002307	active site
862965002308	putative lysogenization regulator; Reviewed; Region: PRK00218
862965002309	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
862965002310	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
862965002311	active site
862965002312	HIGH motif; other site
862965002313	dimer interface [polypeptide binding]; other site
862965002314	KMSKS motif; other site
862965002315	conserved hypothetical protein; Region: TIGR00743
862965002316	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
862965002317	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862965002318	FeS/SAM binding site; other site
862965002319	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
862965002320	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
862965002321	Nucleoside recognition; Region: Gate; pfam07670
862965002322	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
862965002323	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
862965002324	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
862965002325	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
862965002326	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
862965002327	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
862965002328	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
862965002329	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
862965002330	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
862965002331	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
862965002332	RNA binding site [nucleotide binding]; other site
862965002333	Protein of unknown function (DUF1436); Region: DUF1436; pfam07262
862965002334	glycerol kinase; Provisional; Region: glpK; PRK00047
862965002335	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
862965002336	N- and C-terminal domain interface [polypeptide binding]; other site
862965002337	active site
862965002338	MgATP binding site [chemical binding]; other site
862965002339	catalytic site [active]
862965002340	metal binding site [ion binding]; metal-binding site
862965002341	glycerol binding site [chemical binding]; other site
862965002342	homotetramer interface [polypeptide binding]; other site
862965002343	homodimer interface [polypeptide binding]; other site
862965002344	FBP binding site [chemical binding]; other site
862965002345	protein IIAGlc interface [polypeptide binding]; other site
862965002346	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
862965002347	amphipathic channel; other site
862965002348	Asn-Pro-Ala signature motifs; other site
862965002349	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
862965002350	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
862965002351	Walker A/P-loop; other site
862965002352	ATP binding site [chemical binding]; other site
862965002353	Q-loop/lid; other site
862965002354	ABC transporter signature motif; other site
862965002355	Walker B; other site
862965002356	D-loop; other site
862965002357	H-loop/switch region; other site
862965002358	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
862965002359	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965002360	dimer interface [polypeptide binding]; other site
862965002361	conserved gate region; other site
862965002362	putative PBP binding loops; other site
862965002363	ABC-ATPase subunit interface; other site
862965002364	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
862965002365	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
862965002366	substrate binding pocket [chemical binding]; other site
862965002367	membrane-bound complex binding site; other site
862965002368	hinge residues; other site
862965002369	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
862965002370	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
862965002371	dimer interface [polypeptide binding]; other site
862965002372	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862965002373	catalytic residue [active]
862965002374	putative sulfate transport protein CysZ; Validated; Region: PRK04949
862965002375	cell division protein ZipA; Provisional; Region: PRK01741
862965002376	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
862965002377	FtsZ protein binding site [polypeptide binding]; other site
862965002378	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
862965002379	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
862965002380	nucleotide binding pocket [chemical binding]; other site
862965002381	K-X-D-G motif; other site
862965002382	catalytic site [active]
862965002383	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
862965002384	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
862965002385	Helix-hairpin-helix motif; Region: HHH; pfam00633
862965002386	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
862965002387	Dimer interface [polypeptide binding]; other site
862965002388	BRCT sequence motif; other site
862965002389	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
862965002390	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222
862965002391	aromatic amino acid transport protein; Region: araaP; TIGR00837
862965002392	thymidine kinase; Provisional; Region: PRK04296
862965002393	UGMP family protein; Validated; Region: PRK09604
862965002394	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
862965002395	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
862965002396	DNA primase; Validated; Region: dnaG; PRK05667
862965002397	CHC2 zinc finger; Region: zf-CHC2; pfam01807
862965002398	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
862965002399	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
862965002400	active site
862965002401	metal binding site [ion binding]; metal-binding site
862965002402	interdomain interaction site; other site
862965002403	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
862965002404	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
862965002405	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
862965002406	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
862965002407	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
862965002408	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
862965002409	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
862965002410	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
862965002411	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
862965002412	DNA binding residues [nucleotide binding]
862965002413	Predicted membrane protein [Function unknown]; Region: COG3223
862965002414	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
862965002415	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
862965002416	Transglycosylase; Region: Transgly; pfam00912
862965002417	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
862965002418	Competence protein A; Region: Competence_A; pfam11104
862965002419	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
862965002420	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
862965002421	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
862965002422	comF family protein; Region: comF; TIGR00201
862965002423	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862965002424	active site
862965002425	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
862965002426	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
862965002427	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
862965002428	Mg chelatase-related protein; Region: TIGR00368
862965002429	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
862965002430	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862965002431	Walker A motif; other site
862965002432	ATP binding site [chemical binding]; other site
862965002433	Walker B motif; other site
862965002434	arginine finger; other site
862965002435	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
862965002436	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
862965002437	G1 box; other site
862965002438	GTP/Mg2+ binding site [chemical binding]; other site
862965002439	Switch I region; other site
862965002440	G2 box; other site
862965002441	G3 box; other site
862965002442	Switch II region; other site
862965002443	G4 box; other site
862965002444	G5 box; other site
862965002445	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
862965002446	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
862965002447	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
862965002448	Walker A/P-loop; other site
862965002449	ATP binding site [chemical binding]; other site
862965002450	Q-loop/lid; other site
862965002451	ABC transporter signature motif; other site
862965002452	Walker B; other site
862965002453	D-loop; other site
862965002454	H-loop/switch region; other site
862965002455	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
862965002456	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
862965002457	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
862965002458	Walker A/P-loop; other site
862965002459	ATP binding site [chemical binding]; other site
862965002460	Q-loop/lid; other site
862965002461	ABC transporter signature motif; other site
862965002462	Walker B; other site
862965002463	D-loop; other site
862965002464	H-loop/switch region; other site
862965002465	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
862965002466	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
862965002467	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
862965002468	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965002469	dimer interface [polypeptide binding]; other site
862965002470	conserved gate region; other site
862965002471	ABC-ATPase subunit interface; other site
862965002472	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
862965002473	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965002474	dimer interface [polypeptide binding]; other site
862965002475	conserved gate region; other site
862965002476	putative PBP binding loops; other site
862965002477	ABC-ATPase subunit interface; other site
862965002478	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
862965002479	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
862965002480	peptide binding site [polypeptide binding]; other site
862965002481	transaldolase-like protein; Provisional; Region: PTZ00411
862965002482	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
862965002483	active site
862965002484	dimer interface [polypeptide binding]; other site
862965002485	catalytic residue [active]
862965002486	Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853
862965002487	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
862965002488	homotrimer interaction site [polypeptide binding]; other site
862965002489	putative active site [active]
862965002490	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
862965002491	23S rRNA interface [nucleotide binding]; other site
862965002492	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
862965002493	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
862965002494	core dimer interface [polypeptide binding]; other site
862965002495	peripheral dimer interface [polypeptide binding]; other site
862965002496	L10 interface [polypeptide binding]; other site
862965002497	L11 interface [polypeptide binding]; other site
862965002498	putative EF-Tu interaction site [polypeptide binding]; other site
862965002499	putative EF-G interaction site [polypeptide binding]; other site
862965002500	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
862965002501	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
862965002502	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
862965002503	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
862965002504	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
862965002505	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
862965002506	RPB1 interaction site [polypeptide binding]; other site
862965002507	RPB11 interaction site [polypeptide binding]; other site
862965002508	RPB10 interaction site [polypeptide binding]; other site
862965002509	RPB3 interaction site [polypeptide binding]; other site
862965002510	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
862965002511	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
862965002512	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
862965002513	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
862965002514	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
862965002515	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
862965002516	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
862965002517	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
862965002518	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
862965002519	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
862965002520	DNA binding site [nucleotide binding]
862965002521	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
862965002522	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
862965002523	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
862965002524	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965002525	ABC-ATPase subunit interface; other site
862965002526	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
862965002527	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
862965002528	Walker A/P-loop; other site
862965002529	ATP binding site [chemical binding]; other site
862965002530	Q-loop/lid; other site
862965002531	ABC transporter signature motif; other site
862965002532	Walker B; other site
862965002533	D-loop; other site
862965002534	H-loop/switch region; other site
862965002535	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
862965002536	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
862965002537	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862965002538	active site
862965002539	motif I; other site
862965002540	motif II; other site
862965002541	Der GTPase activator; Provisional; Region: PRK05244
862965002542	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
862965002543	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
862965002544	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862965002545	FeS/SAM binding site; other site
862965002546	HemN C-terminal domain; Region: HemN_C; pfam06969
862965002547	diaminopimelate decarboxylase; Region: lysA; TIGR01048
862965002548	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
862965002549	active site
862965002550	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
862965002551	substrate binding site [chemical binding]; other site
862965002552	catalytic residues [active]
862965002553	dimer interface [polypeptide binding]; other site
862965002554	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
862965002555	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
862965002556	putative iron binding site [ion binding]; other site
862965002557	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
862965002558	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
862965002559	ATP binding site [chemical binding]; other site
862965002560	putative Mg++ binding site [ion binding]; other site
862965002561	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862965002562	nucleotide binding region [chemical binding]; other site
862965002563	ATP-binding site [chemical binding]; other site
862965002564	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
862965002565	HRDC domain; Region: HRDC; pfam00570
862965002566	glycine radical enzyme, YjjI family; Region: glycyl_YjjI; TIGR04040
862965002567	Pyruvate formate lyase; Region: PFL; pfam02901
862965002568	Predicted membrane protein [Function unknown]; Region: COG2364
862965002569	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
862965002570	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
862965002571	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
862965002572	putative active site [active]
862965002573	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
862965002574	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
862965002575	active site
862965002576	intersubunit interface [polypeptide binding]; other site
862965002577	zinc binding site [ion binding]; other site
862965002578	Na+ binding site [ion binding]; other site
862965002579	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
862965002580	Phosphoglycerate kinase; Region: PGK; pfam00162
862965002581	substrate binding site [chemical binding]; other site
862965002582	hinge regions; other site
862965002583	ADP binding site [chemical binding]; other site
862965002584	catalytic site [active]
862965002585	Ribonuclease I [Translation, ribosomal structure and biogenesis]; Region: Rna; COG3719
862965002586	CAS motifs; other site
862965002587	active site
862965002588	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
862965002589	benzoate transport; Region: 2A0115; TIGR00895
862965002590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862965002591	putative substrate translocation pore; other site
862965002592	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
862965002593	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
862965002594	HAMP domain; Region: HAMP; pfam00672
862965002595	Histidine kinase; Region: HisKA_3; pfam07730
862965002596	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862965002597	ATP binding site [chemical binding]; other site
862965002598	Mg2+ binding site [ion binding]; other site
862965002599	G-X-G motif; other site
862965002600	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
862965002601	FAD binding domain; Region: FAD_binding_4; pfam01565
862965002602	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
862965002603	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084
862965002604	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
862965002605	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
862965002606	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
862965002607	DNA binding residues [nucleotide binding]
862965002608	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
862965002609	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
862965002610	homooctamer interface [polypeptide binding]; other site
862965002611	active site
862965002612	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
862965002613	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
862965002614	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
862965002615	DNA binding residues [nucleotide binding]
862965002616	dimer interface [polypeptide binding]; other site
862965002617	putative metal binding site [ion binding]; other site
862965002618	NnrS protein; Region: NnrS; cl01258
862965002619	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
862965002620	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965002621	Walker A/P-loop; other site
862965002622	ATP binding site [chemical binding]; other site
862965002623	Q-loop/lid; other site
862965002624	ABC transporter signature motif; other site
862965002625	Walker B; other site
862965002626	D-loop; other site
862965002627	H-loop/switch region; other site
862965002628	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
862965002629	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965002630	dimer interface [polypeptide binding]; other site
862965002631	conserved gate region; other site
862965002632	putative PBP binding loops; other site
862965002633	ABC-ATPase subunit interface; other site
862965002634	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
862965002635	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
862965002636	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
862965002637	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
862965002638	trimer interface [polypeptide binding]; other site
862965002639	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
862965002640	trimer interface [polypeptide binding]; other site
862965002641	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
862965002642	trimer interface [polypeptide binding]; other site
862965002643	YadA-like C-terminal region; Region: YadA; pfam03895
862965002644	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
862965002645	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
862965002646	Ligand binding site; other site
862965002647	metal-binding site
862965002649	FtsI repressor; Provisional; Region: PRK10883
862965002650	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
862965002651	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
862965002652	putative acyl-acceptor binding pocket; other site
862965002653	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
862965002654	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
862965002655	putative active site [active]
862965002656	putative metal binding site [ion binding]; other site
862965002657	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
862965002658	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
862965002659	glutaminase active site [active]
862965002660	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
862965002661	dimer interface [polypeptide binding]; other site
862965002662	active site
862965002663	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
862965002664	dimer interface [polypeptide binding]; other site
862965002665	active site
862965002666	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
862965002667	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
862965002668	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
862965002669	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
862965002670	IHF dimer interface [polypeptide binding]; other site
862965002671	IHF - DNA interface [nucleotide binding]; other site
862965002672	Protein of unknown function (DUF416); Region: DUF416; cl01166
862965002673	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
862965002674	substrate binding site [chemical binding]; other site
862965002675	active site
862965002676	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
862965002677	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
862965002678	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
862965002679	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
862965002680	putative NADH binding site [chemical binding]; other site
862965002681	putative active site [active]
862965002682	nudix motif; other site
862965002683	putative metal binding site [ion binding]; other site
862965002684	Predicted membrane protein [Function unknown]; Region: COG2323
862965002685	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222
862965002686	aromatic amino acid transport protein; Region: araaP; TIGR00837
862965002687	hypothetical protein; Provisional; Region: PRK11820
862965002688	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
862965002689	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
862965002690	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
862965002691	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
862965002692	Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702
862965002693	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
862965002694	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
862965002695	putative active site [active]
862965002696	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
862965002697	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
862965002698	active site
862965002699	substrate binding site [chemical binding]; other site
862965002700	metal binding site [ion binding]; metal-binding site
862965002701	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
862965002702	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
862965002703	substrate binding site [chemical binding]; other site
862965002704	oxyanion hole (OAH) forming residues; other site
862965002705	trimer interface [polypeptide binding]; other site
862965002706	O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441
862965002707	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
862965002708	active site
862965002709	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
862965002710	Dehydroquinase class II; Region: DHquinase_II; pfam01220
862965002711	active site
862965002712	trimer interface [polypeptide binding]; other site
862965002713	dimer interface [polypeptide binding]; other site
862965002714	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
862965002715	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
862965002716	carboxyltransferase (CT) interaction site; other site
862965002717	biotinylation site [posttranslational modification]; other site
862965002718	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
862965002719	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
862965002720	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
862965002721	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
862965002722	Surface protein; Region: DUF3664; pfam12406
862965002723	Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298
862965002724	Predicted membrane protein [Function unknown]; Region: COG3924
862965002725	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
862965002726	putative transporter; Provisional; Region: PRK10484
862965002727	Na binding site [ion binding]; other site
862965002728	EamA-like transporter family; Region: EamA; pfam00892
862965002729	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
862965002730	EamA-like transporter family; Region: EamA; pfam00892
862965002731	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
862965002732	Methyltransferase domain; Region: Methyltransf_18; pfam12847
862965002733	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
862965002734	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
862965002735	FMN binding site [chemical binding]; other site
862965002736	active site
862965002737	catalytic residues [active]
862965002738	substrate binding site [chemical binding]; other site
862965002739	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
862965002740	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
862965002741	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
862965002742	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
862965002743	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
862965002744	TonB system transport protein ExbD, group 2; Region: ExbD_2; TIGR02804
862965002745	tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805
862965002746	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
862965002747	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
862965002748	catalytic triad [active]
862965002749	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
862965002750	dihydrodipicolinate synthase; Region: dapA; TIGR00674
862965002751	dimer interface [polypeptide binding]; other site
862965002752	active site
862965002753	catalytic residue [active]
862965002754	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
862965002755	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
862965002756	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036
862965002757	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
862965002758	ArsC family; Region: ArsC; pfam03960
862965002759	catalytic residues [active]
862965002760	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
862965002761	Domain of unknown function DUF20; Region: UPF0118; pfam01594
862965002762	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
862965002763	homodimer interaction site [polypeptide binding]; other site
862965002764	cofactor binding site; other site
862965002765	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
862965002766	UbiA prenyltransferase family; Region: UbiA; pfam01040
862965002767	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
862965002768	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
862965002769	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
862965002770	transmembrane helices; other site
862965002771	benzoate transport; Region: 2A0115; TIGR00895
862965002772	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862965002773	putative substrate translocation pore; other site
862965002774	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862965002775	hypothetical protein; Provisional; Region: PRK11212
862965002776	outer membrane receptor FepA; Provisional; Region: PRK13524
862965002777	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
862965002778	N-terminal plug; other site
862965002779	ligand-binding site [chemical binding]; other site
862965002780	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
862965002781	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
862965002782	N-terminal plug; other site
862965002783	ligand-binding site [chemical binding]; other site
862965002784	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
862965002785	adenine DNA glycosylase; Provisional; Region: PRK10880
862965002786	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
862965002787	minor groove reading motif; other site
862965002788	helix-hairpin-helix signature motif; other site
862965002789	substrate binding pocket [chemical binding]; other site
862965002790	active site
862965002791	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
862965002792	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
862965002793	DNA binding and oxoG recognition site [nucleotide binding]
862965002794	oxidative damage protection protein; Provisional; Region: PRK05408
862965002795	murein transglycosylase C; Provisional; Region: mltC; PRK11671
862965002796	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
862965002797	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
862965002798	N-acetyl-D-glucosamine binding site [chemical binding]; other site
862965002799	catalytic residue [active]
862965002800	glutathione reductase; Validated; Region: PRK06116
862965002801	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
862965002802	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
862965002803	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
862965002804	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
862965002805	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
862965002806	putative active site [active]
862965002807	putative dimer interface [polypeptide binding]; other site
862965002808	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
862965002809	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
862965002810	putative acyl-acceptor binding pocket; other site
862965002811	LexA repressor; Validated; Region: PRK00215
862965002812	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
862965002813	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
862965002814	Catalytic site [active]
862965002815	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
862965002816	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
862965002817	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
862965002818	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
862965002819	active site
862965002820	zinc binding site [ion binding]; other site
862965002821	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
862965002822	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
862965002823	FMN binding site [chemical binding]; other site
862965002824	active site
862965002825	catalytic residues [active]
862965002826	substrate binding site [chemical binding]; other site
862965002827	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
862965002828	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
862965002829	putative metal binding site [ion binding]; other site
862965002830	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
862965002831	HSP70 interaction site [polypeptide binding]; other site
862965002832	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862965002833	active site
862965002834	ribonuclease PH; Reviewed; Region: rph; PRK00173
862965002835	Ribonuclease PH; Region: RNase_PH_bact; cd11362
862965002836	hexamer interface [polypeptide binding]; other site
862965002837	active site
862965002838	putative transporter; Provisional; Region: PRK11660
862965002839	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
862965002840	Sulfate transporter family; Region: Sulfate_transp; pfam00916
862965002841	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
862965002842	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
862965002843	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
862965002844	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
862965002845	homodimer interface [polypeptide binding]; other site
862965002846	NADP binding site [chemical binding]; other site
862965002847	substrate binding site [chemical binding]; other site
862965002848	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
862965002849	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
862965002850	Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786
862965002851	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
862965002852	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
862965002853	active site
862965002854	metal binding site [ion binding]; metal-binding site
862965002855	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
862965002856	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
862965002857	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
862965002858	rRNA binding site [nucleotide binding]; other site
862965002859	predicted 30S ribosome binding site; other site
862965002860	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
862965002861	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
862965002862	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
862965002863	ribosomal protein L9; Region: L9; TIGR00158
862965002864	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
862965002865	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
862965002866	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
862965002867	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
862965002868	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
862965002869	tetrameric interface [polypeptide binding]; other site
862965002870	NAD binding site [chemical binding]; other site
862965002871	catalytic residues [active]
862965002872	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
862965002873	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
862965002874	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
862965002875	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
862965002876	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
862965002877	putative ligand binding site [chemical binding]; other site
862965002878	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
862965002879	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
862965002880	putative ligand binding site [chemical binding]; other site
862965002881	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
862965002882	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
862965002883	Walker A/P-loop; other site
862965002884	ATP binding site [chemical binding]; other site
862965002885	Q-loop/lid; other site
862965002886	ABC transporter signature motif; other site
862965002887	Walker B; other site
862965002888	D-loop; other site
862965002889	H-loop/switch region; other site
862965002890	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
862965002891	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
862965002892	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
862965002893	TM-ABC transporter signature motif; other site
862965002894	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
862965002895	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
862965002896	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
862965002897	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
862965002898	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
862965002899	Metal-binding active site; metal-binding site
862965002900	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
862965002901	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
862965002902	PYR/PP interface [polypeptide binding]; other site
862965002903	dimer interface [polypeptide binding]; other site
862965002904	TPP binding site [chemical binding]; other site
862965002905	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
862965002906	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
862965002907	TPP-binding site; other site
862965002908	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
862965002909	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
862965002910	substrate binding site [chemical binding]; other site
862965002911	ATP binding site [chemical binding]; other site
862965002912	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
862965002913	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
862965002914	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
862965002915	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
862965002916	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
862965002917	putative active site [active]
862965002918	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
862965002919	Iron-sulfur protein interface; other site
862965002920	proximal quinone binding site [chemical binding]; other site
862965002921	C-subunit interface; other site
862965002922	distal quinone binding site; other site
862965002923	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
862965002924	D-subunit interface [polypeptide binding]; other site
862965002925	Iron-sulfur protein interface; other site
862965002926	proximal quinone binding site [chemical binding]; other site
862965002927	distal quinone binding site [chemical binding]; other site
862965002928	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
862965002929	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
862965002930	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
862965002931	L-aspartate oxidase; Provisional; Region: PRK06175
862965002932	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
862965002933	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
862965002934	poxB regulator PoxA; Provisional; Region: PRK09350
862965002935	motif 1; other site
862965002936	dimer interface [polypeptide binding]; other site
862965002937	active site
862965002938	motif 2; other site
862965002939	motif 3; other site
862965002940	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
862965002941	serine transporter; Region: stp; TIGR00814
862965002942	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
862965002943	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
862965002944	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
862965002945	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
862965002946	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
862965002947	putative active site [active]
862965002948	putative metal binding site [ion binding]; other site
862965002949	hypothetical protein; Validated; Region: PRK00153
862965002950	recombination protein RecR; Reviewed; Region: recR; PRK00076
862965002951	RecR protein; Region: RecR; pfam02132
862965002952	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
862965002953	putative active site [active]
862965002954	putative metal-binding site [ion binding]; other site
862965002955	tetramer interface [polypeptide binding]; other site
862965002956	DNA topoisomerase III; Provisional; Region: PRK07726
862965002957	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
862965002958	active site
862965002959	putative interdomain interaction site [polypeptide binding]; other site
862965002960	putative metal-binding site [ion binding]; other site
862965002961	putative nucleotide binding site [chemical binding]; other site
862965002962	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
862965002963	domain I; other site
862965002964	DNA binding groove [nucleotide binding]
862965002965	phosphate binding site [ion binding]; other site
862965002966	domain II; other site
862965002967	domain III; other site
862965002968	nucleotide binding site [chemical binding]; other site
862965002969	catalytic site [active]
862965002970	domain IV; other site
862965002971	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
862965002972	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
862965002973	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
862965002974	active site turn [active]
862965002975	phosphorylation site [posttranslational modification]
862965002976	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
862965002977	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
862965002978	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
862965002979	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
862965002980	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
862965002981	substrate binding pocket [chemical binding]; other site
862965002982	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
862965002983	B12 binding site [chemical binding]; other site
862965002984	cobalt ligand [ion binding]; other site
862965002985	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
862965002986	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
862965002987	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
862965002988	substrate binding site [chemical binding]; other site
862965002989	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
862965002990	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
862965002991	substrate binding site [chemical binding]; other site
862965002992	ligand binding site [chemical binding]; other site
862965002993	tartrate dehydrogenase; Region: TTC; TIGR02089
862965002994	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
862965002995	2-isopropylmalate synthase; Validated; Region: PRK00915
862965002996	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
862965002997	active site
862965002998	catalytic residues [active]
862965002999	metal binding site [ion binding]; metal-binding site
862965003000	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
862965003001	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
862965003002	DNA protecting protein DprA; Region: dprA; TIGR00732
862965003003	hypothetical protein; Validated; Region: PRK02101
862965003004	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
862965003005	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
862965003006	active site
862965003007	ADP/pyrophosphate binding site [chemical binding]; other site
862965003008	dimerization interface [polypeptide binding]; other site
862965003009	allosteric effector site; other site
862965003010	fructose-1,6-bisphosphate binding site; other site
862965003011	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
862965003012	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
862965003013	folate binding site [chemical binding]; other site
862965003014	NADP+ binding site [chemical binding]; other site
862965003015	gamma-glutamyl kinase; Provisional; Region: PRK05429
862965003016	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
862965003017	nucleotide binding site [chemical binding]; other site
862965003018	homotetrameric interface [polypeptide binding]; other site
862965003019	putative phosphate binding site [ion binding]; other site
862965003020	putative allosteric binding site; other site
862965003021	PUA domain; Region: PUA; pfam01472
862965003022	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
862965003023	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
862965003024	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
862965003025	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
862965003026	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
862965003027	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
862965003028	domain interface [polypeptide binding]; other site
862965003029	putative active site [active]
862965003030	catalytic site [active]
862965003031	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
862965003032	domain interface [polypeptide binding]; other site
862965003033	putative active site [active]
862965003034	catalytic site [active]
862965003035	putative methyltransferase; Provisional; Region: PRK10864
862965003036	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
862965003037	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
862965003038	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
862965003039	CHAP domain; Region: CHAP; pfam05257
862965003040	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
862965003041	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
862965003042	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
862965003043	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
862965003044	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
862965003045	4Fe-4S binding domain; Region: Fer4_5; pfam12801
862965003046	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
862965003047	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
862965003048	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
862965003049	[4Fe-4S] binding site [ion binding]; other site
862965003050	molybdopterin cofactor binding site; other site
862965003051	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
862965003052	molybdopterin cofactor binding site; other site
862965003053	NapD protein; Region: NapD; pfam03927
862965003054	ferredoxin-type protein NapF; Region: napF; TIGR00402
862965003055	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
862965003056	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
862965003057	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
862965003058	4Fe-4S binding domain; Region: Fer4; cl02805
862965003059	hypothetical protein; Provisional; Region: PRK11702
862965003060	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
862965003061	primosome assembly protein PriA; Validated; Region: PRK05580
862965003062	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
862965003063	ATP binding site [chemical binding]; other site
862965003064	putative Mg++ binding site [ion binding]; other site
862965003065	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
862965003066	ATP-binding site [chemical binding]; other site
862965003067	Sporulation related domain; Region: SPOR; cl10051
862965003068	Sporulation related domain; Region: SPOR; pfam05036
862965003069	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
862965003070	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
862965003071	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
862965003072	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
862965003073	HlyD family secretion protein; Region: HlyD_3; pfam13437
862965003074	multidrug efflux protein; Reviewed; Region: PRK09579
862965003075	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
862965003076	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222
862965003077	aromatic amino acid transport protein; Region: araaP; TIGR00837
862965003078	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
862965003079	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862965003080	S-adenosylmethionine binding site [chemical binding]; other site
862965003081	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
862965003082	rRNA interaction site [nucleotide binding]; other site
862965003083	S8 interaction site; other site
862965003084	putative laminin-1 binding site; other site
862965003085	elongation factor Ts; Provisional; Region: tsf; PRK09377
862965003086	UBA/TS-N domain; Region: UBA; pfam00627
862965003087	Elongation factor TS; Region: EF_TS; pfam00889
862965003088	Elongation factor TS; Region: EF_TS; pfam00889
862965003089	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
862965003090	Sulfatase; Region: Sulfatase; pfam00884
862965003091	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
862965003092	putative nucleotide binding site [chemical binding]; other site
862965003093	uridine monophosphate binding site [chemical binding]; other site
862965003094	homohexameric interface [polypeptide binding]; other site
862965003095	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
862965003096	ribosome recycling factor; Reviewed; Region: frr; PRK00083
862965003097	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
862965003098	hinge region; other site
862965003099	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
862965003100	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
862965003101	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
862965003102	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
862965003103	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
862965003104	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
862965003105	catalytic residue [active]
862965003106	putative FPP diphosphate  binding site; other site
862965003107	putative FPP binding hydrophobic cleft; other site
862965003108	dimer interface [polypeptide binding]; other site
862965003109	putative IPP diphosphate binding site; other site
862965003110	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
862965003111	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
862965003112	zinc metallopeptidase RseP; Provisional; Region: PRK10779
862965003113	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
862965003114	active site
862965003115	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
862965003116	protein binding site [polypeptide binding]; other site
862965003117	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
862965003118	protein binding site [polypeptide binding]; other site
862965003119	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
862965003120	putative substrate binding region [chemical binding]; other site
862965003121	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
862965003122	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
862965003123	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
862965003124	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
862965003125	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
862965003126	Surface antigen; Region: Bac_surface_Ag; pfam01103
862965003127	periplasmic chaperone; Provisional; Region: PRK10780
862965003128	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
862965003129	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
862965003130	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
862965003131	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
862965003132	trimer interface [polypeptide binding]; other site
862965003133	active site
862965003134	UDP-GlcNAc binding site [chemical binding]; other site
862965003135	lipid binding site [chemical binding]; lipid-binding site
862965003136	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
862965003137	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
862965003138	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
862965003139	active site
862965003140	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
862965003141	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
862965003142	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
862965003143	RNA/DNA hybrid binding site [nucleotide binding]; other site
862965003144	active site
862965003145	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
862965003146	transmembrane helices; other site
862965003147	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
862965003148	TrkA-C domain; Region: TrkA_C; pfam02080
862965003149	TrkA-C domain; Region: TrkA_C; pfam02080
862965003150	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
862965003151	Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298
862965003152	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
862965003153	Aspartase; Region: Aspartase; cd01357
862965003154	active sites [active]
862965003155	tetramer interface [polypeptide binding]; other site
862965003156	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
862965003157	oligomerisation interface [polypeptide binding]; other site
862965003158	mobile loop; other site
862965003159	roof hairpin; other site
862965003160	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
862965003161	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
862965003162	ring oligomerisation interface [polypeptide binding]; other site
862965003163	ATP/Mg binding site [chemical binding]; other site
862965003164	stacking interactions; other site
862965003165	hinge regions; other site
862965003166	hypothetical protein; Reviewed; Region: PRK01736
862965003167	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
862965003168	proline aminopeptidase P II; Provisional; Region: PRK10879
862965003169	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
862965003170	active site
862965003171	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
862965003172	Ligand Binding Site [chemical binding]; other site
862965003173	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
862965003174	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
862965003175	motif 1; other site
862965003176	active site
862965003177	motif 2; other site
862965003178	motif 3; other site
862965003179	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
862965003180	DHHA1 domain; Region: DHHA1; pfam02272
862965003181	carbon storage regulator; Provisional; Region: PRK01712
862965003182	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
862965003183	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
862965003184	active site
862965003185	tetramer interface; other site
862965003186	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
862965003187	amphipathic channel; other site
862965003188	Asn-Pro-Ala signature motifs; other site
862965003189	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
862965003190	dimerization interface [polypeptide binding]; other site
862965003191	DNA binding site [nucleotide binding]
862965003192	corepressor binding sites; other site
862965003193	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
862965003194	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
862965003195	DNA binding residues [nucleotide binding]
862965003196	dimer interface [polypeptide binding]; other site
862965003197	copper binding site [ion binding]; other site
862965003198	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
862965003199	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
862965003200	metal-binding site [ion binding]
862965003201	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
862965003202	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
862965003203	metal-binding site [ion binding]
862965003204	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
862965003205	C2 domain; Region: C2; cl14603
862965003206	Soluble P-type ATPase [General function prediction only]; Region: COG4087
862965003207	two-component sensor protein; Provisional; Region: cpxA; PRK09470
862965003208	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
862965003209	dimerization interface [polypeptide binding]; other site
862965003210	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
862965003211	dimer interface [polypeptide binding]; other site
862965003212	phosphorylation site [posttranslational modification]
862965003213	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862965003214	ATP binding site [chemical binding]; other site
862965003215	Mg2+ binding site [ion binding]; other site
862965003216	G-X-G motif; other site
862965003217	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
862965003218	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862965003219	active site
862965003220	phosphorylation site [posttranslational modification]
862965003221	intermolecular recognition site; other site
862965003222	dimerization interface [polypeptide binding]; other site
862965003223	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
862965003224	DNA binding site [nucleotide binding]
862965003225	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
862965003226	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
862965003227	Nucleoid-associated protein [General function prediction only]; Region: COG3081
862965003228	nucleoid-associated protein NdpA; Validated; Region: PRK00378
862965003229	Protein of unknown function (DUF1414); Region: DUF1414; cl01175
862965003230	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
862965003231	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
862965003232	Sulfatase; Region: Sulfatase; cl17466
862965003233	hypothetical protein; Validated; Region: PRK06886
862965003234	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
862965003235	active site
862965003236	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
862965003237	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
862965003238	HIGH motif; other site
862965003239	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
862965003240	active site
862965003241	KMSKS motif; other site
862965003242	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
862965003243	Transglycosylase; Region: Transgly; cl17702
862965003244	Trp operon repressor; Provisional; Region: PRK01381
862965003245	lytic murein transglycosylase; Provisional; Region: PRK11619
862965003246	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
862965003247	N-acetyl-D-glucosamine binding site [chemical binding]; other site
862965003248	catalytic residue [active]
862965003249	YciI-like protein; Reviewed; Region: PRK11370
862965003250	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
862965003251	intracellular septation protein A; Reviewed; Region: PRK00259
862965003252	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
862965003253	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
862965003254	active site
862965003255	substrate binding site [chemical binding]; other site
862965003256	cosubstrate binding site; other site
862965003257	catalytic site [active]
862965003258	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
862965003259	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
862965003260	dimerization interface [polypeptide binding]; other site
862965003261	putative ATP binding site [chemical binding]; other site
862965003262	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691
862965003263	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
862965003264	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
862965003265	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
862965003266	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
862965003267	DNA binding site [nucleotide binding]
862965003268	active site
862965003269	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
862965003270	putative DNA-binding cleft [nucleotide binding]; other site
862965003271	putative DNA clevage site; other site
862965003272	molecular lever; other site
862965003273	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
862965003274	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
862965003275	Ligand Binding Site [chemical binding]; other site
862965003276	TilS substrate binding domain; Region: TilS; pfam09179
862965003277	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
862965003278	pyridoxamine kinase; Validated; Region: PRK05756
862965003279	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
862965003280	dimer interface [polypeptide binding]; other site
862965003281	pyridoxal binding site [chemical binding]; other site
862965003282	ATP binding site [chemical binding]; other site
862965003283	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
862965003284	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
862965003285	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
862965003286	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
862965003287	ABC-ATPase subunit  interface; other site
862965003288	dimer interface [polypeptide binding]; other site
862965003289	putative PBP binding regions; other site
862965003290	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
862965003291	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965003292	Walker A/P-loop; other site
862965003293	ATP binding site [chemical binding]; other site
862965003294	Q-loop/lid; other site
862965003295	ABC transporter signature motif; other site
862965003296	Walker B; other site
862965003297	D-loop; other site
862965003298	H-loop/switch region; other site
862965003299	putative peptidase; Provisional; Region: PRK11649
862965003300	Peptidase family M23; Region: Peptidase_M23; pfam01551
862965003301	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
862965003302	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
862965003303	ABC-ATPase subunit  interface; other site
862965003304	dimer interface [polypeptide binding]; other site
862965003305	putative PBP binding regions; other site
862965003306	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
862965003307	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
862965003308	ABC-ATPase subunit  interface; other site
862965003309	dimer interface [polypeptide binding]; other site
862965003310	putative PBP binding regions; other site
862965003311	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
862965003312	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
862965003313	Walker A/P-loop; other site
862965003314	ATP binding site [chemical binding]; other site
862965003315	Q-loop/lid; other site
862965003316	ABC transporter signature motif; other site
862965003317	Walker B; other site
862965003318	D-loop; other site
862965003319	H-loop/switch region; other site
862965003320	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
862965003321	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
862965003322	putative ligand binding residues [chemical binding]; other site
862965003323	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
862965003324	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862965003325	Walker A motif; other site
862965003326	ATP binding site [chemical binding]; other site
862965003327	Walker B motif; other site
862965003328	arginine finger; other site
862965003329	GTPase HflX; Provisional; Region: PRK11058
862965003330	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
862965003331	HflX GTPase family; Region: HflX; cd01878
862965003332	G1 box; other site
862965003333	GTP/Mg2+ binding site [chemical binding]; other site
862965003334	Switch I region; other site
862965003335	G2 box; other site
862965003336	G3 box; other site
862965003337	Switch II region; other site
862965003338	G4 box; other site
862965003339	G5 box; other site
862965003340	bacterial Hfq-like; Region: Hfq; cd01716
862965003341	hexamer interface [polypeptide binding]; other site
862965003342	Sm1 motif; other site
862965003343	RNA binding site [nucleotide binding]; other site
862965003344	Sm2 motif; other site
862965003345	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
862965003346	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
862965003347	RNA binding surface [nucleotide binding]; other site
862965003348	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
862965003349	active site
862965003350	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
862965003351	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
862965003352	homodimer interface [polypeptide binding]; other site
862965003353	oligonucleotide binding site [chemical binding]; other site
862965003354	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
862965003355	Primosomal replication protein priB and priC; Region: priB_priC; cl11483
862965003356	Predicted permease [General function prediction only]; Region: COG2056
862965003357	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
862965003358	ribonuclease T; Provisional; Region: PRK05168
862965003359	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
862965003360	active site
862965003361	catalytic site [active]
862965003362	substrate binding site [chemical binding]; other site
862965003363	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
862965003364	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
862965003365	dimer interface [polypeptide binding]; other site
862965003366	active site
862965003367	metal binding site [ion binding]; metal-binding site
862965003368	glutathione binding site [chemical binding]; other site
862965003369	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
862965003370	Pectate lyase; Region: Pec_lyase_C; cl01593
862965003371	Predicted membrane protein [Function unknown]; Region: COG4984
862965003372	Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925
862965003373	Domain of unknown function (DUF4401); Region: DUF4401; pfam14351
862965003374	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
862965003375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862965003376	S-adenosylmethionine binding site [chemical binding]; other site
862965003377	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
862965003378	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
862965003379	dimer interface [polypeptide binding]; other site
862965003380	anticodon binding site; other site
862965003381	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
862965003382	homodimer interface [polypeptide binding]; other site
862965003383	motif 1; other site
862965003384	active site
862965003385	motif 2; other site
862965003386	GAD domain; Region: GAD; pfam02938
862965003387	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
862965003388	active site
862965003389	motif 3; other site
862965003390	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
862965003391	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
862965003392	nudix motif; other site
862965003393	hypothetical protein; Validated; Region: PRK00110
862965003394	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
862965003395	active site
862965003396	putative DNA-binding cleft [nucleotide binding]; other site
862965003397	dimer interface [polypeptide binding]; other site
862965003398	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
862965003399	RuvA N terminal domain; Region: RuvA_N; pfam01330
862965003400	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
862965003401	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
862965003402	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862965003403	Walker A motif; other site
862965003404	ATP binding site [chemical binding]; other site
862965003405	Walker B motif; other site
862965003406	arginine finger; other site
862965003407	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
862965003408	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
862965003409	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
862965003410	cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203
862965003411	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
862965003412	Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; cl11451
862965003413	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
862965003414	active site
862965003415	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
862965003416	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
862965003417	colicin uptake protein TolR; Provisional; Region: PRK11024
862965003418	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
862965003419	TolA C-terminal; Region: TolA; pfam06519
862965003420	translocation protein TolB; Provisional; Region: tolB; PRK01742
862965003421	TolB amino-terminal domain; Region: TolB_N; pfam04052
862965003422	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
862965003423	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
862965003424	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
862965003425	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
862965003426	ligand binding site [chemical binding]; other site
862965003427	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
862965003428	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
862965003429	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
862965003430	Rrf2 family protein; Region: rrf2_super; TIGR00738
862965003431	cysteine desulfurase; Provisional; Region: PRK14012
862965003432	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
862965003433	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
862965003434	catalytic residue [active]
862965003435	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
862965003436	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
862965003437	trimerization site [polypeptide binding]; other site
862965003438	active site
862965003439	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
862965003440	co-chaperone HscB; Provisional; Region: hscB; PRK01773
862965003441	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
862965003442	HSP70 interaction site [polypeptide binding]; other site
862965003443	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
862965003444	Protein of unknown function DUF2625; Region: DUF2625; pfam10946
862965003445	chaperone protein HscA; Provisional; Region: hscA; PRK05183
862965003446	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
862965003447	nucleotide binding site [chemical binding]; other site
862965003448	putative NEF/HSP70 interaction site [polypeptide binding]; other site
862965003449	SBD interface [polypeptide binding]; other site
862965003450	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
862965003451	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
862965003452	catalytic loop [active]
862965003453	iron binding site [ion binding]; other site
862965003454	Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384
862965003455	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862965003456	S-adenosylmethionine binding site [chemical binding]; other site
862965003457	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
862965003458	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
862965003459	TM-ABC transporter signature motif; other site
862965003460	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
862965003461	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
862965003462	Walker A/P-loop; other site
862965003463	ATP binding site [chemical binding]; other site
862965003464	Q-loop/lid; other site
862965003465	ABC transporter signature motif; other site
862965003466	Walker B; other site
862965003467	D-loop; other site
862965003468	H-loop/switch region; other site
862965003469	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
862965003470	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
862965003471	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
862965003472	ligand binding site [chemical binding]; other site
862965003473	calcium binding site [ion binding]; other site
862965003474	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
862965003475	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
862965003476	DNA binding site [nucleotide binding]
862965003477	domain linker motif; other site
862965003478	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
862965003479	ligand binding site [chemical binding]; other site
862965003480	dimerization interface (closed form) [polypeptide binding]; other site
862965003481	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
862965003482	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
862965003483	dimer interface [polypeptide binding]; other site
862965003484	active site
862965003485	galactokinase; Provisional; Region: PRK05101
862965003486	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
862965003487	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
862965003488	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
862965003489	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
862965003490	active site
862965003491	catalytic residues [active]
862965003492	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
862965003493	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
862965003494	Transporter associated domain; Region: CorC_HlyC; smart01091
862965003495	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
862965003496	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
862965003497	putative active site [active]
862965003498	catalytic triad [active]
862965003499	putative dimer interface [polypeptide binding]; other site
862965003500	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
862965003501	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
862965003502	Walker A/P-loop; other site
862965003503	ATP binding site [chemical binding]; other site
862965003504	Q-loop/lid; other site
862965003505	ABC transporter signature motif; other site
862965003506	Walker B; other site
862965003507	D-loop; other site
862965003508	H-loop/switch region; other site
862965003509	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
862965003510	conserved hypothetical integral membrane protein; Region: TIGR00056
862965003511	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
862965003512	mce related protein; Region: MCE; pfam02470
862965003513	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
862965003514	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
862965003515	anti sigma factor interaction site; other site
862965003516	regulatory phosphorylation site [posttranslational modification]; other site
862965003517	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
862965003518	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
862965003519	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
862965003520	hinge; other site
862965003521	active site
862965003522	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
862965003523	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
862965003524	catalytic residue [active]
862965003525	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
862965003526	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
862965003527	nucleotide binding site [chemical binding]; other site
862965003528	substrate binding site [chemical binding]; other site
862965003529	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
862965003530	dimer interface [polypeptide binding]; other site
862965003531	putative threonine allosteric regulatory site; other site
862965003532	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
862965003533	putative threonine allosteric regulatory site; other site
862965003534	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
862965003535	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
862965003536	homoserine kinase; Region: thrB; TIGR00191
862965003537	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
862965003538	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
862965003539	threonine synthase; Validated; Region: PRK09225
862965003540	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
862965003541	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
862965003542	catalytic residue [active]
862965003543	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
862965003544	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
862965003545	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
862965003546	active site turn [active]
862965003547	phosphorylation site [posttranslational modification]
862965003548	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
862965003549	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
862965003550	FtsH protease regulator HflK; Provisional; Region: PRK10930
862965003551	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
862965003552	FtsH protease regulator HflC; Provisional; Region: PRK11029
862965003553	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
862965003554	Haem-binding domain; Region: Haem_bd; pfam14376
862965003555	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
862965003556	metabolite-proton symporter; Region: 2A0106; TIGR00883
862965003557	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
862965003558	thiamine phosphate binding site [chemical binding]; other site
862965003559	active site
862965003560	pyrophosphate binding site [ion binding]; other site
862965003561	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
862965003562	dimer interface [polypeptide binding]; other site
862965003563	substrate binding site [chemical binding]; other site
862965003564	ATP binding site [chemical binding]; other site
862965003565	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
862965003566	substrate binding site [chemical binding]; other site
862965003567	multimerization interface [polypeptide binding]; other site
862965003568	ATP binding site [chemical binding]; other site
862965003569	Putative transcription activator [Transcription]; Region: TenA; COG0819
862965003570	NMT1/THI5 like; Region: NMT1; pfam09084
862965003571	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
862965003572	substrate binding pocket [chemical binding]; other site
862965003573	membrane-bound complex binding site; other site
862965003574	hinge residues; other site
862965003575	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
862965003576	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965003577	dimer interface [polypeptide binding]; other site
862965003578	conserved gate region; other site
862965003579	putative PBP binding loops; other site
862965003580	ABC-ATPase subunit interface; other site
862965003581	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
862965003582	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965003583	Walker A/P-loop; other site
862965003584	ATP binding site [chemical binding]; other site
862965003585	Q-loop/lid; other site
862965003586	ABC transporter signature motif; other site
862965003587	Walker B; other site
862965003588	D-loop; other site
862965003589	H-loop/switch region; other site
862965003590	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
862965003591	active site
862965003592	catalytic residues [active]
862965003593	DNA binding site [nucleotide binding]
862965003594	Int/Topo IB signature motif; other site
862965003595	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
862965003596	Putative helicase; Region: TraI_2; pfam07514
862965003597	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
862965003598	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
862965003599	active site
862965003600	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862965003601	active site
862965003602	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
862965003603	putative DNA binding site [nucleotide binding]; other site
862965003604	putative Zn2+ binding site [ion binding]; other site
862965003605	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
862965003606	RelB antitoxin; Region: RelB; cl01171
862965003607	multiple promoter invertase; Provisional; Region: mpi; PRK13413
862965003608	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
862965003609	catalytic residues [active]
862965003610	catalytic nucleophile [active]
862965003611	Presynaptic Site I dimer interface [polypeptide binding]; other site
862965003612	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
862965003613	Synaptic Flat tetramer interface [polypeptide binding]; other site
862965003614	Synaptic Site I dimer interface [polypeptide binding]; other site
862965003615	DNA binding site [nucleotide binding]
862965003616	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
862965003617	DNA-binding interface [nucleotide binding]; DNA binding site
862965003618	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
862965003619	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
862965003620	Sodium/glutamate symporter; Region: Glt_symporter; pfam03616
862965003621	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
862965003622	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
862965003623	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
862965003624	dimerization interface [polypeptide binding]; other site
862965003625	putative DNA binding site [nucleotide binding]; other site
862965003626	putative Zn2+ binding site [ion binding]; other site
862965003627	tetracycline repressor protein TetR; Provisional; Region: PRK13756
862965003628	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
862965003629	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
862965003630	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862965003631	putative substrate translocation pore; other site
862965003632	Major Facilitator Superfamily; Region: MFS_1; pfam07690
862965003633	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
862965003634	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
862965003635	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
862965003636	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
862965003637	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
862965003638	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
862965003639	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
862965003640	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
862965003641	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
862965003642	integrating conjugative element protein, PFL_4709 family; Region: conj_TIGR03757
862965003643	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
862965003644	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
862965003645	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
862965003646	catalytic residue [active]
862965003647	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
862965003648	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
862965003649	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
862965003650	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
862965003651	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
862965003652	Protein of unknown function (DUF3438); Region: DUF3438; pfam11920
862965003653	integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746
862965003654	Protein of unknown function (DUF3487); Region: DUF3487; pfam11990
862965003655	Protein of unknown function (DUF2976); Region: DUF2976; pfam11190
862965003656	Protein of unknown function (DUF3262); Region: DUF3262; pfam11660
862965003657	integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690
862965003658	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
862965003659	integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747
862965003660	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
862965003661	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
862965003662	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
862965003663	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
862965003664	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
862965003665	N-acetyl-D-glucosamine binding site [chemical binding]; other site
862965003666	catalytic residue [active]
862965003667	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
862965003668	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
862965003669	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
862965003670	conjugal transfer protein TrbP; Provisional; Region: PRK13882
862965003671	TraX protein; Region: TraX; pfam05857
862965003672	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
862965003673	MPN+ (JAMM) motif; other site
862965003674	Zinc-binding site [ion binding]; other site
862965003675	Domain of unknown function (DUF3560); Region: DUF3560; pfam12083
862965003676	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
862965003677	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
862965003678	putative active site [active]
862965003679	AAA domain; Region: AAA_21; pfam13304
862965003680	DNA topoisomerase III; Provisional; Region: PRK07726
862965003681	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
862965003682	active site
862965003683	putative interdomain interaction site [polypeptide binding]; other site
862965003684	putative metal-binding site [ion binding]; other site
862965003685	putative nucleotide binding site [chemical binding]; other site
862965003686	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
862965003687	domain I; other site
862965003688	DNA binding groove [nucleotide binding]
862965003689	phosphate binding site [ion binding]; other site
862965003690	domain II; other site
862965003691	domain III; other site
862965003692	nucleotide binding site [chemical binding]; other site
862965003693	catalytic site [active]
862965003694	domain IV; other site
862965003695	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
862965003696	YedD-like protein; Region: YedD; cl08117
862965003697	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
862965003698	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
862965003699	dimer interface [polypeptide binding]; other site
862965003700	ssDNA binding site [nucleotide binding]; other site
862965003701	tetramer (dimer of dimers) interface [polypeptide binding]; other site
862965003702	Protein of unknown function (DUF3158); Region: DUF3158; pfam11358
862965003703	integrating conjugative element protein, PFL_4669 family; Region: ICE_PFL4669; TIGR03761
862965003704	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
862965003705	integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764
862965003706	ParB-like nuclease domain; Region: ParBc; pfam02195
862965003707	replicative DNA helicase; Region: DnaB; TIGR00665
862965003708	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
862965003709	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
862965003710	Walker A motif; other site
862965003711	ATP binding site [chemical binding]; other site
862965003712	Walker B motif; other site
862965003713	DNA binding loops [nucleotide binding]
862965003714	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
862965003715	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
862965003716	P-loop; other site
862965003717	Magnesium ion binding site [ion binding]; other site
862965003718	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
862965003719	Magnesium ion binding site [ion binding]; other site
862965003720	cystathionine gamma-synthase; Reviewed; Region: PRK08247
862965003721	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
862965003722	homodimer interface [polypeptide binding]; other site
862965003723	substrate-cofactor binding pocket; other site
862965003724	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862965003725	catalytic residue [active]
862965003726	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
862965003727	catalytic residues [active]
862965003728	DNA ligase; Provisional; Region: PRK09125
862965003729	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
862965003730	DNA binding site [nucleotide binding]
862965003731	active site
862965003732	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
862965003733	DNA binding site [nucleotide binding]
862965003734	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
862965003735	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
862965003736	dimer interface [polypeptide binding]; other site
862965003737	active site
862965003738	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
862965003739	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965003740	Walker A/P-loop; other site
862965003741	ATP binding site [chemical binding]; other site
862965003742	Q-loop/lid; other site
862965003743	ABC transporter signature motif; other site
862965003744	Walker B; other site
862965003745	D-loop; other site
862965003746	H-loop/switch region; other site
862965003747	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
862965003748	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
862965003749	substrate binding pocket [chemical binding]; other site
862965003750	membrane-bound complex binding site; other site
862965003751	hinge residues; other site
862965003752	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
862965003753	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965003754	dimer interface [polypeptide binding]; other site
862965003755	conserved gate region; other site
862965003756	putative PBP binding loops; other site
862965003757	ABC-ATPase subunit interface; other site
862965003758	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965003759	dimer interface [polypeptide binding]; other site
862965003760	conserved gate region; other site
862965003761	putative PBP binding loops; other site
862965003762	ABC-ATPase subunit interface; other site
862965003763	Predicted transcriptional regulator [Transcription]; Region: COG2378
862965003764	WYL domain; Region: WYL; pfam13280
862965003765	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
862965003766	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
862965003767	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
862965003768	NAD-dependent deacetylase; Provisional; Region: PRK00481
862965003769	NAD+ binding site [chemical binding]; other site
862965003770	substrate binding site [chemical binding]; other site
862965003771	Zn binding site [ion binding]; other site
862965003772	Opioid growth factor receptor (OGFr) conserved region; Region: OGFr_N; pfam04664
862965003773	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
862965003774	Fic/DOC family; Region: Fic; pfam02661
862965003775	Fic/DOC family; Region: Fic; cl00960
862965003777	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
862965003778	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296
862965003779	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
862965003780	active site
862965003781	Protein of unknown function DUF262; Region: DUF262; pfam03235
862965003782	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862965003783	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
862965003784	Walker A motif; other site
862965003785	ATP binding site [chemical binding]; other site
862965003786	Walker B motif; other site
862965003787	arginine finger; other site
862965003788	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862965003789	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
862965003790	Walker A motif; other site
862965003791	ATP binding site [chemical binding]; other site
862965003792	Walker B motif; other site
862965003793	arginine finger; other site
862965003794	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
862965003795	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
862965003796	Carbon starvation protein CstA; Region: CstA; pfam02554
862965003797	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
862965003798	cell division protein MraZ; Reviewed; Region: PRK00326
862965003799	MraZ protein; Region: MraZ; pfam02381
862965003800	MraZ protein; Region: MraZ; pfam02381
862965003801	16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006
862965003802	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
862965003803	Cell division protein [Cell division and chromosome partitioning]; Region: FtsL; COG3116
862965003804	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
862965003805	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
862965003806	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
862965003807	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
862965003808	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
862965003809	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
862965003810	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
862965003811	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
862965003812	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
862965003813	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
862965003814	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
862965003815	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
862965003816	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
862965003817	Mg++ binding site [ion binding]; other site
862965003818	putative catalytic motif [active]
862965003819	putative substrate binding site [chemical binding]; other site
862965003820	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
862965003821	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
862965003822	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
862965003823	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
862965003824	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
862965003825	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
862965003826	active site
862965003827	homodimer interface [polypeptide binding]; other site
862965003828	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
862965003829	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
862965003830	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
862965003831	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
862965003832	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
862965003833	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
862965003834	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
862965003835	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
862965003836	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
862965003837	Cell division protein FtsQ; Region: FtsQ; pfam03799
862965003838	cell division protein FtsA; Region: ftsA; TIGR01174
862965003839	Cell division protein FtsA; Region: FtsA; smart00842
862965003840	Cell division protein FtsA; Region: FtsA; pfam14450
862965003841	cell division protein FtsZ; Region: ftsZ; TIGR00065
862965003842	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
862965003843	nucleotide binding site [chemical binding]; other site
862965003844	SulA interaction site; other site
862965003845	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
862965003846	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
862965003847	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
862965003848	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
862965003849	active site
862965003850	metal binding site [ion binding]; metal-binding site
862965003851	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
862965003852	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
862965003853	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
862965003854	Prephenate dehydratase; Region: PDT; pfam00800
862965003855	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
862965003856	putative L-Phe binding site [chemical binding]; other site
862965003857	alkylphosphonate utilization operon protein PhnA; Region: phnA; TIGR00686
862965003858	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
862965003859	PhnA protein; Region: PhnA; pfam03831
862965003860	Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398
862965003861	Putative zinc-finger; Region: zf-HC2; pfam13490
862965003862	RNA polymerase sigma factor; Provisional; Region: PRK12530
862965003863	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
862965003864	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
862965003865	DNA binding residues [nucleotide binding]
862965003866	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3219
862965003867	Protein of unknown function (DUF692); Region: DUF692; pfam05114
862965003868	Uncharacterized low-complexity protein [Function unknown]; Region: COG3767
862965003869	Predicted membrane protein [Function unknown]; Region: COG2259
862965003870	Integrase core domain; Region: rve_3; cl15866
862965003871	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
862965003872	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
862965003873	active site
862965003874	HIGH motif; other site
862965003875	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
862965003876	KMSKS motif; other site
862965003877	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
862965003878	tRNA binding surface [nucleotide binding]; other site
862965003879	anticodon binding site; other site
862965003880	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
862965003881	substrate binding site [chemical binding]; other site
862965003882	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
862965003883	active site
862965003884	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
862965003885	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862965003886	FeS/SAM binding site; other site
862965003887	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
862965003888	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862965003889	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
862965003890	Walker A/P-loop; other site
862965003891	ATP binding site [chemical binding]; other site
862965003892	Q-loop/lid; other site
862965003893	ABC transporter signature motif; other site
862965003894	Walker B; other site
862965003895	D-loop; other site
862965003896	H-loop/switch region; other site
862965003897	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
862965003898	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862965003899	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965003900	Walker A/P-loop; other site
862965003901	ATP binding site [chemical binding]; other site
862965003902	Q-loop/lid; other site
862965003903	ABC transporter signature motif; other site
862965003904	Walker B; other site
862965003905	D-loop; other site
862965003906	H-loop/switch region; other site
862965003907	thioredoxin reductase; Provisional; Region: PRK10262
862965003908	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
862965003909	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
862965003910	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
862965003911	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
862965003912	xanthine permease; Region: pbuX; TIGR03173
862965003913	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
862965003914	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
862965003915	transmembrane helices; other site
862965003917	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
862965003918	putative uracil binding site [chemical binding]; other site
862965003919	putative active site [active]
862965003920	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
862965003921	ATP cone domain; Region: ATP-cone; pfam03477
862965003922	Class III ribonucleotide reductase; Region: RNR_III; cd01675
862965003923	effector binding site; other site
862965003924	active site
862965003925	Zn binding site [ion binding]; other site
862965003926	glycine loop; other site
862965003927	GrpE; Region: GrpE; pfam01025
862965003928	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
862965003929	dimer interface [polypeptide binding]; other site
862965003930	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
862965003931	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
862965003932	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
862965003933	recombination and repair protein; Provisional; Region: PRK10869
862965003934	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
862965003935	Walker A/P-loop; other site
862965003936	ATP binding site [chemical binding]; other site
862965003937	Q-loop/lid; other site
862965003938	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
862965003939	ABC transporter signature motif; other site
862965003940	Walker B; other site
862965003941	D-loop; other site
862965003942	H-loop/switch region; other site
862965003943	S-adenosylmethionine synthetase; Validated; Region: PRK05250
862965003944	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
862965003945	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
862965003946	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
862965003947	hypothetical protein; Provisional; Region: PRK04860
862965003948	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
862965003949	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
862965003950	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
862965003951	ArsC family; Region: ArsC; pfam03960
862965003952	putative catalytic residues [active]
862965003953	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
862965003954	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
862965003955	N-terminal plug; other site
862965003956	ligand-binding site [chemical binding]; other site
862965003957	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
862965003958	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
862965003959	metal binding site [ion binding]; metal-binding site
862965003960	dimer interface [polypeptide binding]; other site
862965003961	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
862965003962	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
862965003963	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
862965003964	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
862965003965	active site
862965003966	phosphorylation site [posttranslational modification]
862965003967	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
862965003968	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
862965003969	Walker A/P-loop; other site
862965003970	ATP binding site [chemical binding]; other site
862965003971	Q-loop/lid; other site
862965003972	ABC transporter signature motif; other site
862965003973	Walker B; other site
862965003974	D-loop; other site
862965003975	H-loop/switch region; other site
862965003976	OstA-like protein; Region: OstA; cl00844
862965003977	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
862965003978	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
862965003979	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
862965003980	hypothetical protein; Provisional; Region: PRK05255
862965003981	peptidase PmbA; Provisional; Region: PRK11040
862965003982	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
862965003983	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862965003984	active site
862965003985	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
862965003986	GTP-binding protein Der; Reviewed; Region: PRK00093
862965003987	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
862965003988	G1 box; other site
862965003989	GTP/Mg2+ binding site [chemical binding]; other site
862965003990	Switch I region; other site
862965003991	G2 box; other site
862965003992	Switch II region; other site
862965003993	G3 box; other site
862965003994	G4 box; other site
862965003995	G5 box; other site
862965003996	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
862965003997	G1 box; other site
862965003998	GTP/Mg2+ binding site [chemical binding]; other site
862965003999	Switch I region; other site
862965004000	G2 box; other site
862965004001	G3 box; other site
862965004002	Switch II region; other site
862965004003	G4 box; other site
862965004004	G5 box; other site
862965004005	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
862965004006	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
862965004007	active site
862965004008	catalytic site [active]
862965004009	substrate binding site [chemical binding]; other site
862965004010	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
862965004011	RNA/DNA hybrid binding site [nucleotide binding]; other site
862965004012	active site
862965004013	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
862965004014	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
862965004015	active site
862965004016	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
862965004017	catalytic triad [active]
862965004018	dimer interface [polypeptide binding]; other site
862965004019	GTP-binding protein YchF; Reviewed; Region: PRK09601
862965004020	YchF GTPase; Region: YchF; cd01900
862965004021	G1 box; other site
862965004022	GTP/Mg2+ binding site [chemical binding]; other site
862965004023	Switch I region; other site
862965004024	G2 box; other site
862965004025	Switch II region; other site
862965004026	G3 box; other site
862965004027	G4 box; other site
862965004028	G5 box; other site
862965004029	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
862965004030	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
862965004031	putative active site [active]
862965004032	catalytic residue [active]
862965004033	Predicted membrane protein [Function unknown]; Region: COG2510
862965004034	hypothetical protein; Validated; Region: PRK01777
862965004035	Uncharacterized conserved protein [Function unknown]; Region: COG2850
862965004036	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
862965004037	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
862965004038	generic binding surface II; other site
862965004039	generic binding surface I; other site
862965004040	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
862965004041	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
862965004042	dimer interface [polypeptide binding]; other site
862965004043	ADP-ribose binding site [chemical binding]; other site
862965004044	active site
862965004045	nudix motif; other site
862965004046	metal binding site [ion binding]; metal-binding site
862965004047	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
862965004048	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
862965004049	active site
862965004050	metal binding site [ion binding]; metal-binding site
862965004051	hexamer interface [polypeptide binding]; other site
862965004052	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
862965004053	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
862965004054	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862965004055	FeS/SAM binding site; other site
862965004056	TRAM domain; Region: TRAM; pfam01938
862965004057	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
862965004058	peroxidase; Provisional; Region: PRK15000
862965004059	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
862965004060	dimer interface [polypeptide binding]; other site
862965004061	decamer (pentamer of dimers) interface [polypeptide binding]; other site
862965004062	catalytic triad [active]
862965004063	peroxidatic and resolving cysteines [active]
862965004064	cystathionine beta-lyase; Provisional; Region: PRK08114
862965004065	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
862965004066	homodimer interface [polypeptide binding]; other site
862965004067	substrate-cofactor binding pocket; other site
862965004068	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862965004069	catalytic residue [active]
862965004070	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
862965004071	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
862965004072	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
862965004073	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
862965004074	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241
862965004075	PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736
862965004076	murein transglycosylase A; Provisional; Region: mltA; PRK11162
862965004077	MltA specific insert domain; Region: MltA; smart00925
862965004078	3D domain; Region: 3D; pfam06725
862965004079	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
862965004080	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
862965004081	putative ATP binding site [chemical binding]; other site
862965004082	putative substrate interface [chemical binding]; other site
862965004083	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
862965004084	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
862965004085	metal binding site [ion binding]; metal-binding site
862965004086	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
862965004087	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
862965004088	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862965004089	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
862965004090	putative RNA binding site [nucleotide binding]; other site
862965004091	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862965004092	S-adenosylmethionine binding site [chemical binding]; other site
862965004093	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
862965004094	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
862965004095	TrkA-N domain; Region: TrkA_N; pfam02254
862965004096	Predicted membrane protein [Function unknown]; Region: COG2707
862965004097	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
862965004098	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
862965004099	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
862965004100	ATP binding site [chemical binding]; other site
862965004101	putative Mg++ binding site [ion binding]; other site
862965004102	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862965004103	nucleotide binding region [chemical binding]; other site
862965004104	ATP-binding site [chemical binding]; other site
862965004105	Helicase associated domain (HA2); Region: HA2; pfam04408
862965004106	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
862965004107	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
862965004108	AAA domain; Region: AAA_21; pfam13304
862965004109	PIN domain; Region: PIN; pfam01850
862965004110	putative active site [active]
862965004111	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
862965004112	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
862965004113	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
862965004114	catalytic center binding site [active]
862965004115	ATP binding site [chemical binding]; other site
862965004116	poly(A) polymerase; Region: pcnB; TIGR01942
862965004117	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
862965004118	active site
862965004119	NTP binding site [chemical binding]; other site
862965004120	metal binding triad [ion binding]; metal-binding site
862965004121	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
862965004122	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
862965004123	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
862965004124	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
862965004125	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
862965004126	Competence protein; Region: Competence; pfam03772
862965004127	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
862965004128	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
862965004129	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
862965004130	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
862965004131	Walker A/P-loop; other site
862965004132	ATP binding site [chemical binding]; other site
862965004133	Q-loop/lid; other site
862965004134	ABC transporter signature motif; other site
862965004135	Walker B; other site
862965004136	D-loop; other site
862965004137	H-loop/switch region; other site
862965004138	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
862965004139	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
862965004140	Uncharacterized conserved protein [Function unknown]; Region: COG2835
862965004141	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
862965004142	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
862965004143	Ligand binding site; other site
862965004144	oligomer interface; other site
862965004145	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
862965004146	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
862965004147	active site
862965004148	catalytic site [active]
862965004149	putative DNA binding site [nucleotide binding]; other site
862965004150	GIY-YIG motif/motif A; other site
862965004151	metal binding site [ion binding]; metal-binding site
862965004152	UvrB/uvrC motif; Region: UVR; pfam02151
862965004153	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
862965004154	Helix-hairpin-helix motif; Region: HHH; pfam00633
862965004155	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
862965004156	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
862965004157	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
862965004158	Walker A/P-loop; other site
862965004159	ATP binding site [chemical binding]; other site
862965004160	Q-loop/lid; other site
862965004161	ABC transporter signature motif; other site
862965004162	Walker B; other site
862965004163	D-loop; other site
862965004164	H-loop/switch region; other site
862965004165	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
862965004166	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965004167	dimer interface [polypeptide binding]; other site
862965004168	conserved gate region; other site
862965004169	putative PBP binding loops; other site
862965004170	ABC-ATPase subunit interface; other site
862965004171	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965004172	dimer interface [polypeptide binding]; other site
862965004173	conserved gate region; other site
862965004174	putative PBP binding loops; other site
862965004175	ABC-ATPase subunit interface; other site
862965004176	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
862965004177	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
862965004178	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
862965004179	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
862965004180	ATP-grasp domain; Region: ATP-grasp_4; cl17255
862965004181	ATP-grasp domain; Region: ATP-grasp_4; cl17255
862965004182	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
862965004183	PhoH-like protein; Region: PhoH; pfam02562
862965004184	metal-binding heat shock protein; Provisional; Region: PRK00016
862965004185	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
862965004186	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862965004187	active site
862965004188	motif I; other site
862965004189	motif II; other site
862965004190	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862965004191	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
862965004192	dimer interface [polypeptide binding]; other site
862965004193	catalytic triad [active]
862965004194	peroxidatic and resolving cysteines [active]
862965004195	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
862965004196	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
862965004197	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862965004198	homodimer interface [polypeptide binding]; other site
862965004199	catalytic residue [active]
862965004200	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
862965004201	homodimer interface [polypeptide binding]; other site
862965004202	substrate-cofactor binding pocket; other site
862965004203	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862965004204	catalytic residue [active]
862965004205	hypothetical protein; Provisional; Region: PRK05423
862965004206	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
862965004207	substrate binding site [chemical binding]; other site
862965004208	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
862965004209	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
862965004210	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862965004211	S-adenosylmethionine binding site [chemical binding]; other site
862965004212	DNA polymerase III, psi subunit; Region: DNA_III_psi; TIGR00664
862965004213	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
862965004214	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
862965004215	Coenzyme A binding pocket [chemical binding]; other site
862965004216	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
862965004217	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
862965004218	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
862965004219	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
862965004220	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
862965004222	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
862965004223	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
862965004224	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
862965004225	Ligand binding site; other site
862965004226	metal-binding site
862965004227	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
862965004228	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
862965004229	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
862965004230	Part of AAA domain; Region: AAA_19; pfam13245
862965004231	Family description; Region: UvrD_C_2; pfam13538
862965004232	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
862965004233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965004234	dimer interface [polypeptide binding]; other site
862965004235	conserved gate region; other site
862965004236	putative PBP binding loops; other site
862965004237	ABC-ATPase subunit interface; other site
862965004238	dipeptide transporter; Provisional; Region: PRK10913
862965004239	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
862965004240	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965004241	dimer interface [polypeptide binding]; other site
862965004242	conserved gate region; other site
862965004243	putative PBP binding loops; other site
862965004244	ABC-ATPase subunit interface; other site
862965004245	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
862965004246	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
862965004247	Walker A/P-loop; other site
862965004248	ATP binding site [chemical binding]; other site
862965004249	Q-loop/lid; other site
862965004250	ABC transporter signature motif; other site
862965004251	Walker B; other site
862965004252	D-loop; other site
862965004253	H-loop/switch region; other site
862965004254	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
862965004255	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
862965004256	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
862965004257	Walker A/P-loop; other site
862965004258	ATP binding site [chemical binding]; other site
862965004259	Q-loop/lid; other site
862965004260	ABC transporter signature motif; other site
862965004261	Walker B; other site
862965004262	D-loop; other site
862965004263	H-loop/switch region; other site
862965004264	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
862965004265	putative arabinose transporter; Provisional; Region: PRK03545
862965004266	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862965004267	putative substrate translocation pore; other site
862965004268	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
862965004269	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
862965004270	trimer interface [polypeptide binding]; other site
862965004271	active site
862965004272	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
862965004273	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
862965004274	Sugar specificity; other site
862965004275	Pyrimidine base specificity; other site
862965004276	ATP-binding site [chemical binding]; other site
862965004277	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
862965004278	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
862965004279	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
862965004280	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
862965004281	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
862965004282	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965004283	dimer interface [polypeptide binding]; other site
862965004284	conserved gate region; other site
862965004285	putative PBP binding loops; other site
862965004286	ABC-ATPase subunit interface; other site
862965004287	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965004288	dimer interface [polypeptide binding]; other site
862965004289	conserved gate region; other site
862965004290	putative PBP binding loops; other site
862965004291	ABC-ATPase subunit interface; other site
862965004292	ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432
862965004293	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
862965004294	Walker A/P-loop; other site
862965004295	ATP binding site [chemical binding]; other site
862965004296	Q-loop/lid; other site
862965004297	ABC transporter signature motif; other site
862965004298	Walker B; other site
862965004299	D-loop; other site
862965004300	H-loop/switch region; other site
862965004301	TOBE domain; Region: TOBE_2; pfam08402
862965004302	Site-specific recombinase; Region: SpecificRecomb; cl15411
862965004303	Transcriptional regulator [Transcription]; Region: LysR; COG0583
862965004304	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
862965004305	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
862965004306	putative dimerization interface [polypeptide binding]; other site
862965004307	AzlC protein; Region: AzlC; cl00570
862965004308	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
862965004309	Membrane transport protein; Region: Mem_trans; cl09117
862965004310	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
862965004311	putative dimer interface [polypeptide binding]; other site
862965004312	catalytic triad [active]
862965004313	GMP synthase; Reviewed; Region: guaA; PRK00074
862965004314	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
862965004315	AMP/PPi binding site [chemical binding]; other site
862965004316	candidate oxyanion hole; other site
862965004317	catalytic triad [active]
862965004318	potential glutamine specificity residues [chemical binding]; other site
862965004319	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
862965004320	ATP Binding subdomain [chemical binding]; other site
862965004321	Ligand Binding sites [chemical binding]; other site
862965004322	Dimerization subdomain; other site
862965004323	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
862965004324	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
862965004325	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
862965004326	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
862965004327	active site
862965004328	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
862965004329	HTH domain; Region: HTH_11; cl17392
862965004330	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
862965004331	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
862965004332	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
862965004333	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
862965004334	dimer interface [polypeptide binding]; other site
862965004335	phosphorylation site [posttranslational modification]
862965004336	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862965004337	ATP binding site [chemical binding]; other site
862965004338	Mg2+ binding site [ion binding]; other site
862965004339	G-X-G motif; other site
862965004340	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862965004341	active site
862965004342	phosphorylation site [posttranslational modification]
862965004343	intermolecular recognition site; other site
862965004344	dimerization interface [polypeptide binding]; other site
862965004345	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
862965004346	putative binding surface; other site
862965004347	active site
862965004348	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
862965004349	Helicase; Region: Helicase_RecD; pfam05127
862965004350	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
862965004351	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
862965004352	transcription-repair coupling factor; Provisional; Region: PRK10689
862965004353	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
862965004354	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
862965004355	ATP binding site [chemical binding]; other site
862965004356	putative Mg++ binding site [ion binding]; other site
862965004357	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862965004358	nucleotide binding region [chemical binding]; other site
862965004359	ATP-binding site [chemical binding]; other site
862965004360	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
862965004361	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
862965004362	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
862965004363	putative NAD(P) binding site [chemical binding]; other site
862965004364	putative active site [active]
862965004365	arginine repressor; Provisional; Region: PRK05066
862965004366	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
862965004367	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
862965004368	malate dehydrogenase; Provisional; Region: PRK05086
862965004369	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
862965004370	NAD binding site [chemical binding]; other site
862965004371	dimerization interface [polypeptide binding]; other site
862965004372	Substrate binding site [chemical binding]; other site
862965004373	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
862965004374	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
862965004375	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862965004376	active site
862965004377	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
862965004378	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
862965004379	outer membrane lipoprotein LolB; Region: lolB; TIGR00548
862965004380	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
862965004381	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
862965004382	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
862965004383	active site
862965004384	NTP binding site [chemical binding]; other site
862965004385	metal binding triad [ion binding]; metal-binding site
862965004386	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
862965004387	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
862965004388	Zn2+ binding site [ion binding]; other site
862965004389	Mg2+ binding site [ion binding]; other site
862965004390	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
862965004391	Bacterial SH3 domain homologues; Region: SH3b; smart00287
862965004392	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
862965004393	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
862965004394	TIGR00153 family protein; Region: TIGR00153
862965004395	Uncharacterized conserved protein [Function unknown]; Region: COG3025
862965004396	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
862965004397	putative active site [active]
862965004398	putative metal binding residues [ion binding]; other site
862965004399	signature motif; other site
862965004400	putative triphosphate binding site [ion binding]; other site
862965004401	DNA repair protein RadA; Region: sms; TIGR00416
862965004402	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
862965004403	Walker A motif/ATP binding site; other site
862965004404	ATP binding site [chemical binding]; other site
862965004405	Walker B motif; other site
862965004406	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
862965004407	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
862965004408	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
862965004409	dimerization interface [polypeptide binding]; other site
862965004410	putative DNA binding site [nucleotide binding]; other site
862965004411	putative Zn2+ binding site [ion binding]; other site
862965004412	AsnC family; Region: AsnC_trans_reg; pfam01037
862965004413	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
862965004414	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
862965004415	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
862965004416	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
862965004417	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
862965004418	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
862965004419	recombination factor protein RarA; Reviewed; Region: PRK13342
862965004420	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862965004421	Walker A motif; other site
862965004422	ATP binding site [chemical binding]; other site
862965004423	Walker B motif; other site
862965004424	arginine finger; other site
862965004425	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
862965004426	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
862965004427	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
862965004428	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
862965004429	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965004430	dimer interface [polypeptide binding]; other site
862965004431	conserved gate region; other site
862965004432	ABC-ATPase subunit interface; other site
862965004433	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
862965004434	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965004435	dimer interface [polypeptide binding]; other site
862965004436	conserved gate region; other site
862965004437	putative PBP binding loops; other site
862965004438	ABC-ATPase subunit interface; other site
862965004439	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
862965004440	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
862965004441	Walker A/P-loop; other site
862965004442	ATP binding site [chemical binding]; other site
862965004443	Q-loop/lid; other site
862965004444	ABC transporter signature motif; other site
862965004445	Walker B; other site
862965004446	D-loop; other site
862965004447	H-loop/switch region; other site
862965004448	TOBE domain; Region: TOBE_2; pfam08402
862965004449	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
862965004450	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
862965004451	metal binding site [ion binding]; metal-binding site
862965004452	dimer interface [polypeptide binding]; other site
862965004453	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
862965004454	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
862965004455	Peptidase M15; Region: Peptidase_M15_3; cl01194
862965004456	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
862965004457	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
862965004458	carboxy-terminal protease; Provisional; Region: PRK11186
862965004459	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
862965004460	protein binding site [polypeptide binding]; other site
862965004461	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
862965004462	Catalytic dyad [active]
862965004463	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
862965004464	ProP expression regulator; Provisional; Region: PRK04950
862965004465	ProQ/FINO family; Region: ProQ; smart00945
862965004466	integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155
862965004467	Paraquat-inducible protein A; Region: PqiA; pfam04403
862965004468	Paraquat-inducible protein A; Region: PqiA; pfam04403
862965004469	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
862965004470	mce related protein; Region: MCE; pfam02470
862965004471	mce related protein; Region: MCE; pfam02470
862965004472	mce related protein; Region: MCE; pfam02470
862965004473	mce related protein; Region: MCE; pfam02470
862965004474	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
862965004475	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
862965004476	active site
862965004477	motif I; other site
862965004478	motif II; other site
862965004479	KpsF/GutQ family protein; Region: kpsF; TIGR00393
862965004480	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
862965004481	putative active site [active]
862965004482	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
862965004483	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
862965004484	active site
862965004485	DNA polymerase IV; Validated; Region: PRK02406
862965004486	DNA binding site [nucleotide binding]
862965004487	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
862965004488	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
862965004489	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676
862965004490	Protein of unknown function (DUF2931); Region: DUF2931; pfam11153
862965004491	Protein of unknown function, DUF462; Region: DUF462; cl01190
862965004492	peptide chain release factor 1; Validated; Region: prfA; PRK00591
862965004493	This domain is found in peptide chain release factors; Region: PCRF; smart00937
862965004494	RF-1 domain; Region: RF-1; pfam00472
862965004495	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
862965004496	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862965004497	Uncharacterized conserved protein [Function unknown]; Region: COG2912
862965004498	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
862965004499	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
862965004500	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
862965004501	glycerate dehydrogenase; Provisional; Region: PRK06932
862965004502	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
862965004503	putative ligand binding site [chemical binding]; other site
862965004504	putative NAD binding site [chemical binding]; other site
862965004505	catalytic site [active]
862965004506	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
862965004507	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
862965004508	FtsX-like permease family; Region: FtsX; pfam02687
862965004509	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
862965004510	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
862965004511	Walker A/P-loop; other site
862965004512	ATP binding site [chemical binding]; other site
862965004513	Q-loop/lid; other site
862965004514	ABC transporter signature motif; other site
862965004515	Walker B; other site
862965004516	D-loop; other site
862965004517	H-loop/switch region; other site
862965004518	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
862965004519	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
862965004520	FtsX-like permease family; Region: FtsX; pfam02687
862965004521	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
862965004522	Protein of unknown function (DUF1043); Region: DUF1043; pfam06295
862965004523	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
862965004524	homotrimer interaction site [polypeptide binding]; other site
862965004525	putative active site [active]
862965004526	YwiC-like protein; Region: YwiC; pfam14256
862965004527	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
862965004528	Sel1-like repeats; Region: SEL1; smart00671
862965004529	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
862965004530	Uncharacterized conserved protein [Function unknown]; Region: COG4121
862965004531	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
862965004532	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
862965004533	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
862965004534	dimer interface [polypeptide binding]; other site
862965004535	active site
862965004536	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06882
862965004537	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
862965004538	PYR/PP interface [polypeptide binding]; other site
862965004539	dimer interface [polypeptide binding]; other site
862965004540	TPP binding site [chemical binding]; other site
862965004541	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
862965004542	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
862965004543	TPP-binding site [chemical binding]; other site
862965004544	dimer interface [polypeptide binding]; other site
862965004545	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
862965004546	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
862965004547	putative valine binding site [chemical binding]; other site
862965004548	dimer interface [polypeptide binding]; other site
862965004549	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
862965004550	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
862965004551	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
862965004552	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965004553	Walker A/P-loop; other site
862965004554	ATP binding site [chemical binding]; other site
862965004555	Q-loop/lid; other site
862965004556	ABC transporter signature motif; other site
862965004557	Walker B; other site
862965004558	D-loop; other site
862965004559	H-loop/switch region; other site
862965004560	TOBE domain; Region: TOBE_2; pfam08402
862965004561	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
862965004562	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965004563	dimer interface [polypeptide binding]; other site
862965004564	conserved gate region; other site
862965004565	putative PBP binding loops; other site
862965004566	ABC-ATPase subunit interface; other site
862965004567	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965004568	dimer interface [polypeptide binding]; other site
862965004569	conserved gate region; other site
862965004570	putative PBP binding loops; other site
862965004571	ABC-ATPase subunit interface; other site
862965004572	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
862965004573	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965004574	Walker A/P-loop; other site
862965004575	ATP binding site [chemical binding]; other site
862965004576	Q-loop/lid; other site
862965004577	ABC transporter signature motif; other site
862965004578	Walker B; other site
862965004579	D-loop; other site
862965004580	H-loop/switch region; other site
862965004581	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
862965004582	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
862965004583	Protein of unknown function, DUF484; Region: DUF484; cl17449
862965004584	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
862965004585	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
862965004586	GDP-binding site [chemical binding]; other site
862965004587	ACT binding site; other site
862965004588	IMP binding site; other site
862965004589	aspartate kinase III; Validated; Region: PRK09084
862965004590	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
862965004591	nucleotide binding site [chemical binding]; other site
862965004592	substrate binding site [chemical binding]; other site
862965004593	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
862965004594	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
862965004595	dimer interface [polypeptide binding]; other site
862965004596	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
862965004597	putative active site [active]
862965004598	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
862965004599	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
862965004600	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
862965004601	putative FMN binding site [chemical binding]; other site
862965004602	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
862965004603	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
862965004604	tandem repeat interface [polypeptide binding]; other site
862965004605	oligomer interface [polypeptide binding]; other site
862965004606	active site residues [active]
862965004607	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
862965004608	tandem repeat interface [polypeptide binding]; other site
862965004609	oligomer interface [polypeptide binding]; other site
862965004610	active site residues [active]
862965004611	bile acid transporter; Region: bass; TIGR00841
862965004612	Sodium Bile acid symporter family; Region: SBF; pfam01758
862965004613	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167
862965004614	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
862965004615	Walker A/P-loop; other site
862965004616	ATP binding site [chemical binding]; other site
862965004617	Q-loop/lid; other site
862965004618	ABC transporter signature motif; other site
862965004619	Walker B; other site
862965004620	D-loop; other site
862965004621	H-loop/switch region; other site
862965004622	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170
862965004623	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
862965004624	Walker A/P-loop; other site
862965004625	ATP binding site [chemical binding]; other site
862965004626	Q-loop/lid; other site
862965004627	ABC transporter signature motif; other site
862965004628	Walker B; other site
862965004629	D-loop; other site
862965004630	H-loop/switch region; other site
862965004631	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
862965004632	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171
862965004633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965004634	putative PBP binding loops; other site
862965004635	dimer interface [polypeptide binding]; other site
862965004636	ABC-ATPase subunit interface; other site
862965004637	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168
862965004638	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965004639	dimer interface [polypeptide binding]; other site
862965004640	conserved gate region; other site
862965004641	putative PBP binding loops; other site
862965004642	ABC-ATPase subunit interface; other site
862965004643	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
862965004644	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
862965004645	peptide binding site [polypeptide binding]; other site
862965004646	Predicted ATPase [General function prediction only]; Region: COG3106
862965004647	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
862965004648	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
862965004649	E-class dimer interface [polypeptide binding]; other site
862965004650	P-class dimer interface [polypeptide binding]; other site
862965004651	active site
862965004652	Cu2+ binding site [ion binding]; other site
862965004653	Zn2+ binding site [ion binding]; other site
862965004654	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
862965004655	metal-binding site [ion binding]
862965004656	MerT mercuric transport protein; Region: MerT; cl03578
862965004657	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
862965004658	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
862965004659	hypothetical protein; Provisional; Region: PRK05415
862965004660	Domain of unknown function (DUF697); Region: DUF697; cl12064
862965004661	peptide chain release factor 2; Validated; Region: prfB; PRK00578
862965004662	This domain is found in peptide chain release factors; Region: PCRF; smart00937
862965004663	RF-1 domain; Region: RF-1; pfam00472
862965004664	electron transport complex protein RnfC; Provisional; Region: PRK05035
862965004665	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
862965004666	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
862965004667	dimerization domain [polypeptide binding]; other site
862965004668	dimer interface [polypeptide binding]; other site
862965004669	catalytic residues [active]
862965004670	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
862965004671	DHH family; Region: DHH; pfam01368
862965004672	DHHA1 domain; Region: DHHA1; pfam02272
862965004673	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
862965004674	catalytic residues [active]
862965004675	hinge region; other site
862965004676	alpha helical domain; other site
862965004677	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
862965004678	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
862965004679	cytidylate kinase; Provisional; Region: cmk; PRK00023
862965004680	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
862965004681	CMP-binding site; other site
862965004682	The sites determining sugar specificity; other site
862965004683	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
862965004684	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
862965004685	RNA binding site [nucleotide binding]; other site
862965004686	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
862965004687	RNA binding site [nucleotide binding]; other site
862965004688	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
862965004689	RNA binding site [nucleotide binding]; other site
862965004690	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
862965004691	RNA binding site [nucleotide binding]; other site
862965004692	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
862965004693	RNA binding site [nucleotide binding]; other site
862965004694	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
862965004695	RNA binding site [nucleotide binding]; other site
862965004696	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
862965004697	IHF dimer interface [polypeptide binding]; other site
862965004698	IHF - DNA interface [nucleotide binding]; other site
862965004699	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
862965004700	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
862965004701	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
862965004702	binding surface
862965004703	TPR motif; other site
862965004704	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
862965004705	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
862965004706	active site
862965004707	dimer interface [polypeptide binding]; other site
862965004708	translation initiation factor Sui1; Validated; Region: PRK06824
862965004709	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
862965004710	putative rRNA binding site [nucleotide binding]; other site
862965004711	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
862965004712	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
862965004713	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
862965004714	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862965004715	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862965004716	ABC transporter; Region: ABC_tran_2; pfam12848
862965004717	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862965004718	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
862965004719	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
862965004720	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
862965004721	dimer interface [polypeptide binding]; other site
862965004722	FMN binding site [chemical binding]; other site
862965004723	Uncharacterized conserved protein [Function unknown]; Region: COG1434
862965004724	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
862965004725	putative active site [active]
862965004726	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
862965004727	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
862965004728	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
862965004729	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
862965004730	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
862965004731	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
862965004732	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
862965004733	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
862965004734	N-terminal plug; other site
862965004735	ligand-binding site [chemical binding]; other site
862965004736	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
862965004737	pyruvate kinase; Provisional; Region: PRK05826
862965004738	domain interfaces; other site
862965004739	active site
862965004740	replicative DNA helicase; Validated; Region: PRK06904
862965004741	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
862965004742	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
862965004743	Walker A motif; other site
862965004744	ATP binding site [chemical binding]; other site
862965004745	Walker B motif; other site
862965004746	DNA binding loops [nucleotide binding]
862965004747	alanine racemase; Reviewed; Region: alr; PRK00053
862965004748	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
862965004749	active site
862965004750	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
862965004751	substrate binding site [chemical binding]; other site
862965004752	catalytic residues [active]
862965004753	dimer interface [polypeptide binding]; other site
862965004754	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
862965004755	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
862965004756	active site
862965004757	dimer interface [polypeptide binding]; other site
862965004758	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
862965004759	dimer interface [polypeptide binding]; other site
862965004760	active site
862965004761	sugar efflux transporter B; Provisional; Region: PRK15011
862965004762	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862965004763	putative substrate translocation pore; other site
862965004764	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
862965004765	active site
862965004766	catalytic residues [active]
862965004767	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
862965004768	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
862965004769	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
862965004770	substrate binding [chemical binding]; other site
862965004771	active site
862965004772	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
862965004773	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
862965004774	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
862965004775	putative substrate binding site [chemical binding]; other site
862965004776	putative ATP binding site [chemical binding]; other site
862965004777	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
862965004778	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
862965004779	active site
862965004780	HIGH motif; other site
862965004781	dimer interface [polypeptide binding]; other site
862965004782	KMSKS motif; other site
862965004783	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
862965004784	RNA binding surface [nucleotide binding]; other site
862965004785	Rhodanese-like domain; Region: Rhodanese; pfam00581
862965004786	active site residue [active]
862965004787	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
862965004788	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
862965004789	active site residue [active]
862965004790	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
862965004791	active site residue [active]
862965004792	Sulphur transport; Region: Sulf_transp; pfam04143
862965004793	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
862965004794	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
862965004795	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
862965004796	YccA-like proteins; Region: YccA_like; cd10433
862965004797	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
862965004798	Helix-hairpin-helix motif; Region: HHH; pfam00633
862965004799	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
862965004800	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
862965004801	TPP-binding site [chemical binding]; other site
862965004802	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
862965004803	PYR/PP interface [polypeptide binding]; other site
862965004804	dimer interface [polypeptide binding]; other site
862965004805	TPP binding site [chemical binding]; other site
862965004806	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
862965004807	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
862965004808	E3 interaction surface; other site
862965004809	lipoyl attachment site [posttranslational modification]; other site
862965004810	e3 binding domain; Region: E3_binding; pfam02817
862965004811	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
862965004812	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
862965004813	Na binding site [ion binding]; other site
862965004814	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
862965004815	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
862965004816	CoA-ligase; Region: Ligase_CoA; pfam00549
862965004817	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
862965004818	CoA binding domain; Region: CoA_binding; pfam02629
862965004819	CoA-ligase; Region: Ligase_CoA; pfam00549
862965004820	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
862965004821	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
862965004822	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
862965004823	RNA binding surface [nucleotide binding]; other site
862965004824	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
862965004825	probable active site [active]
862965004826	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
862965004827	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
862965004828	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
862965004829	substrate binding site [chemical binding]; other site
862965004830	dimerization interface [polypeptide binding]; other site
862965004831	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862965004832	Major Facilitator Superfamily; Region: MFS_1; pfam07690
862965004833	putative substrate translocation pore; other site
862965004834	HemK family putative methylases; Region: hemK_fam; TIGR00536
862965004835	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862965004836	S-adenosylmethionine binding site [chemical binding]; other site
862965004837	hypothetical protein; Provisional; Region: PRK04946
862965004838	Smr domain; Region: Smr; pfam01713
862965004839	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
862965004840	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
862965004841	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
862965004842	active site
862965004843	HIGH motif; other site
862965004844	KMSK motif region; other site
862965004845	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
862965004846	tRNA binding surface [nucleotide binding]; other site
862965004847	anticodon binding site; other site
862965004848	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
862965004849	putative metal binding site [ion binding]; other site
862965004850	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
862965004851	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
862965004852	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
862965004853	trimer interface [polypeptide binding]; other site
862965004854	active site
862965004855	substrate binding site [chemical binding]; other site
862965004856	CoA binding site [chemical binding]; other site
862965004857	tellurite resistance protein TehB; Provisional; Region: PRK12335
862965004858	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
862965004859	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862965004860	S-adenosylmethionine binding site [chemical binding]; other site
862965004861	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
862965004862	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
862965004863	active site
862965004864	HIGH motif; other site
862965004865	KMSKS motif; other site
862965004866	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
862965004867	tRNA binding surface [nucleotide binding]; other site
862965004868	anticodon binding site; other site
862965004869	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
862965004870	dimer interface [polypeptide binding]; other site
862965004871	putative tRNA-binding site [nucleotide binding]; other site
862965004872	antiporter inner membrane protein; Provisional; Region: PRK11670
862965004873	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
862965004874	Walker A motif; other site
862965004875	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
862965004876	catalytic core [active]
862965004877	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
862965004878	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
862965004879	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
862965004880	Walker A/P-loop; other site
862965004881	ATP binding site [chemical binding]; other site
862965004882	Q-loop/lid; other site
862965004883	ABC transporter signature motif; other site
862965004884	Walker B; other site
862965004885	D-loop; other site
862965004886	H-loop/switch region; other site
862965004887	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
862965004888	FtsX-like permease family; Region: FtsX; pfam02687
862965004889	macrolide transporter subunit MacA; Provisional; Region: PRK11578
862965004890	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
862965004891	HlyD family secretion protein; Region: HlyD_3; pfam13437
862965004892	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
862965004893	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
862965004894	active site
862965004895	HIGH motif; other site
862965004896	nucleotide binding site [chemical binding]; other site
862965004897	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
862965004898	KMSKS motif; other site
862965004899	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
862965004900	hypothetical protein; Provisional; Region: PRK05170
862965004901	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
862965004902	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
862965004903	glycogen branching enzyme; Provisional; Region: PRK05402
862965004904	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
862965004905	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
862965004906	active site
862965004907	catalytic site [active]
862965004908	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
862965004909	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
862965004910	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
862965004911	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
862965004912	active site
862965004913	catalytic site [active]
862965004914	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
862965004915	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
862965004916	ligand binding site; other site
862965004917	oligomer interface; other site
862965004918	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
862965004919	N-terminal domain interface [polypeptide binding]; other site
862965004920	sulfate 1 binding site; other site
862965004921	glycogen synthase; Provisional; Region: glgA; PRK00654
862965004922	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
862965004923	ADP-binding pocket [chemical binding]; other site
862965004924	homodimer interface [polypeptide binding]; other site
862965004925	glycogen phosphorylase; Provisional; Region: PRK14986
862965004926	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
862965004927	homodimer interface [polypeptide binding]; other site
862965004928	active site pocket [active]
862965004929	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
862965004930	homopentamer interface [polypeptide binding]; other site
862965004931	active site
862965004932	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
862965004933	putative RNA binding site [nucleotide binding]; other site
862965004934	thiamine monophosphate kinase; Provisional; Region: PRK05731
862965004935	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
862965004936	ATP binding site [chemical binding]; other site
862965004937	dimerization interface [polypeptide binding]; other site
862965004938	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
862965004939	tetramer interfaces [polypeptide binding]; other site
862965004940	binuclear metal-binding site [ion binding]; other site
862965004941	LysE type translocator; Region: LysE; cl00565
862965004942	dihydrodipicolinate reductase; Provisional; Region: PRK00048
862965004943	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
862965004944	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
862965004945	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
862965004946	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
862965004947	catalytic loop [active]
862965004948	iron binding site [ion binding]; other site
862965004949	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
862965004950	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
862965004951	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
862965004952	active site
862965004953	phosphorylation site [posttranslational modification]
862965004954	intermolecular recognition site; other site
862965004955	dimerization interface [polypeptide binding]; other site
862965004956	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
862965004957	DNA binding site [nucleotide binding]
862965004958	sensor protein QseC; Provisional; Region: PRK10337
862965004959	HAMP domain; Region: HAMP; pfam00672
862965004960	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
862965004961	dimer interface [polypeptide binding]; other site
862965004962	phosphorylation site [posttranslational modification]
862965004963	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862965004964	ATP binding site [chemical binding]; other site
862965004965	Mg2+ binding site [ion binding]; other site
862965004966	G-X-G motif; other site
862965004967	Protein of unknown function (DUF1439); Region: DUF1439; pfam07273
862965004968	ribosome maturation protein RimP; Reviewed; Region: PRK00092
862965004969	Sm and related proteins; Region: Sm_like; cl00259
862965004970	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
862965004971	putative oligomer interface [polypeptide binding]; other site
862965004972	putative RNA binding site [nucleotide binding]; other site
862965004973	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
862965004974	NusA N-terminal domain; Region: NusA_N; pfam08529
862965004975	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
862965004976	RNA binding site [nucleotide binding]; other site
862965004977	homodimer interface [polypeptide binding]; other site
862965004978	NusA-like KH domain; Region: KH_5; pfam13184
862965004979	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
862965004980	G-X-X-G motif; other site
862965004981	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
862965004982	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
862965004983	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
862965004984	translation initiation factor IF-2; Region: IF-2; TIGR00487
862965004985	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
862965004986	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
862965004987	G1 box; other site
862965004988	putative GEF interaction site [polypeptide binding]; other site
862965004989	GTP/Mg2+ binding site [chemical binding]; other site
862965004990	Switch I region; other site
862965004991	G2 box; other site
862965004992	G3 box; other site
862965004993	Switch II region; other site
862965004994	G4 box; other site
862965004995	G5 box; other site
862965004996	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
862965004997	Translation-initiation factor 2; Region: IF-2; pfam11987
862965004998	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
862965004999	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
862965005000	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
862965005001	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
862965005002	RNA binding site [nucleotide binding]; other site
862965005003	active site
862965005004	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
862965005005	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
862965005006	chorismate mutase domain of T-protein; Region: CM_T; TIGR01799
862965005007	prephenate dehydrogenase; Validated; Region: PRK08507
862965005008	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
862965005009	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
862965005010	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
862965005011	Zn-ribbon-containing, possibly nucleic-acid-binding protein [General function prediction only]; Region: COG5595
862965005012	Fe-S metabolism associated domain; Region: SufE; cl00951
862965005013	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
862965005014	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
862965005015	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
862965005016	catalytic residue [active]
862965005017	Staphylococcal nuclease homologues; Region: SNc; smart00318
862965005018	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
862965005019	Catalytic site; other site
862965005020	hypothetical protein; Provisional; Region: PRK01821
862965005021	LrgB-like family; Region: LrgB; cl00596
862965005022	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
862965005023	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
862965005024	Zn2+ binding site [ion binding]; other site
862965005025	Mg2+ binding site [ion binding]; other site
862965005026	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
862965005027	ABC transporter ATPase component; Reviewed; Region: PRK11147
862965005028	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862965005029	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965005030	Walker A/P-loop; other site
862965005031	ATP binding site [chemical binding]; other site
862965005032	Q-loop/lid; other site
862965005033	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862965005034	ABC transporter signature motif; other site
862965005035	Walker B; other site
862965005036	D-loop; other site
862965005037	ABC transporter; Region: ABC_tran_2; pfam12848
862965005038	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
862965005039	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
862965005040	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
862965005041	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
862965005042	ATP binding site [chemical binding]; other site
862965005043	putative Mg++ binding site [ion binding]; other site
862965005044	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
862965005045	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
862965005046	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
862965005047	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
862965005048	HsdM N-terminal domain; Region: HsdM_N; pfam12161
862965005049	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
862965005050	Methyltransferase domain; Region: Methyltransf_26; pfam13659
862965005051	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
862965005052	Na2 binding site [ion binding]; other site
862965005053	putative substrate binding site 1 [chemical binding]; other site
862965005054	Na binding site 1 [ion binding]; other site
862965005055	putative substrate binding site 2 [chemical binding]; other site
862965005056	endonuclease III; Provisional; Region: PRK10702
862965005057	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
862965005058	minor groove reading motif; other site
862965005059	helix-hairpin-helix signature motif; other site
862965005060	substrate binding pocket [chemical binding]; other site
862965005061	active site
862965005062	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
862965005063	electron transport complex RsxE subunit; Provisional; Region: PRK12405
862965005064	electron transport complex protein RnfG; Validated; Region: PRK01908
862965005065	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
862965005066	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
862965005067	SLBB domain; Region: SLBB; pfam10531
862965005068	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
862965005069	electron transport complex protein RnfB; Provisional; Region: PRK05113
862965005070	Putative Fe-S cluster; Region: FeS; pfam04060
862965005071	4Fe-4S binding domain; Region: Fer4; pfam00037
862965005072	electron transport complex protein RsxA; Provisional; Region: PRK05151
862965005073	TIGR01666 family membrane protein; Region: YCCS
862965005074	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
862965005075	Mg++ binding site [ion binding]; other site
862965005076	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
862965005077	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
862965005078	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437
862965005079	hypothetical protein; Provisional; Region: PRK03641
862965005080	Acylphosphatase; Region: Acylphosphatase; cl00551
862965005081	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
862965005082	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
862965005083	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
862965005084	probable active site [active]
862965005085	Uncharacterized protein family (UPF0181); Region: UPF0181; pfam03701
862965005086	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
862965005087	DNA-binding site [nucleotide binding]; DNA binding site
862965005088	RNA-binding motif; other site
862965005089	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
862965005090	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
862965005091	Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742
862965005092	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
862965005093	3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Validated; Region: PRK05174
862965005094	active site 2 [active]
862965005095	active site 1 [active]
862965005096	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
862965005097	putative deacylase active site [active]
862965005098	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06901
862965005099	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
862965005100	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
862965005101	DsrE/DsrF-like family; Region: DrsE; cl00672
862965005102	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
862965005103	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
862965005104	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
862965005105	AAA domain; Region: AAA_30; pfam13604
862965005106	Family description; Region: UvrD_C_2; pfam13538
862965005107	glutaredoxin 2; Provisional; Region: PRK10387
862965005108	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
862965005109	C-terminal domain interface [polypeptide binding]; other site
862965005110	GSH binding site (G-site) [chemical binding]; other site
862965005111	catalytic residues [active]
862965005112	putative dimer interface [polypeptide binding]; other site
862965005113	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
862965005114	N-terminal domain interface [polypeptide binding]; other site
862965005115	Uncharacterized conserved protein [Function unknown]; Region: COG2966
862965005116	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
862965005117	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
862965005118	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
862965005119	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
862965005120	Sel1-like repeats; Region: SEL1; smart00671
862965005121	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
862965005122	Sel1-like repeats; Region: SEL1; smart00671
862965005123	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
862965005124	binding surface
862965005125	TPR motif; other site
862965005126	Sel1 repeat; Region: Sel1; pfam08238
862965005127	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
862965005128	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
862965005129	dimerization interface [polypeptide binding]; other site
862965005130	DPS ferroxidase diiron center [ion binding]; other site
862965005131	ion pore; other site
862965005132	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
862965005133	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
862965005134	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
862965005135	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965005136	dimer interface [polypeptide binding]; other site
862965005137	conserved gate region; other site
862965005138	ABC-ATPase subunit interface; other site
862965005139	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
862965005140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965005141	dimer interface [polypeptide binding]; other site
862965005142	conserved gate region; other site
862965005143	putative PBP binding loops; other site
862965005144	ABC-ATPase subunit interface; other site
862965005145	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
862965005146	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
862965005147	Walker A/P-loop; other site
862965005148	ATP binding site [chemical binding]; other site
862965005149	Q-loop/lid; other site
862965005150	ABC transporter signature motif; other site
862965005151	Walker B; other site
862965005152	D-loop; other site
862965005153	H-loop/switch region; other site
862965005154	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
862965005155	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
862965005156	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
862965005157	Walker A/P-loop; other site
862965005158	ATP binding site [chemical binding]; other site
862965005159	Q-loop/lid; other site
862965005160	ABC transporter signature motif; other site
862965005161	Walker B; other site
862965005162	D-loop; other site
862965005163	H-loop/switch region; other site
862965005164	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
862965005165	cytidine deaminase; Provisional; Region: PRK09027
862965005166	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
862965005167	active site
862965005168	catalytic motif [active]
862965005169	Zn binding site [ion binding]; other site
862965005170	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
862965005171	active site
862965005172	catalytic motif [active]
862965005173	Zn binding site [ion binding]; other site
862965005174	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
862965005175	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
862965005176	THF binding site; other site
862965005177	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
862965005178	substrate binding site [chemical binding]; other site
862965005179	THF binding site; other site
862965005180	zinc-binding site [ion binding]; other site
862965005181	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
862965005182	putative ligand binding residues [chemical binding]; other site
862965005183	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
862965005184	outer membrane receptor FepA; Provisional; Region: PRK13524
862965005185	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
862965005186	N-terminal plug; other site
862965005187	ligand-binding site [chemical binding]; other site
862965005188	Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083
862965005189	molybdenum-pterin binding domain; Region: Mop; TIGR00638
862965005190	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
862965005191	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
862965005192	putative ligand binding residues [chemical binding]; other site
862965005193	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
862965005194	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
862965005195	Walker A/P-loop; other site
862965005196	ATP binding site [chemical binding]; other site
862965005197	Q-loop/lid; other site
862965005198	ABC transporter signature motif; other site
862965005199	Walker B; other site
862965005200	D-loop; other site
862965005201	H-loop/switch region; other site
862965005202	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
862965005203	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
862965005204	ABC-ATPase subunit  interface; other site
862965005205	dimer interface [polypeptide binding]; other site
862965005206	putative PBP binding regions; other site
862965005207	AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271
862965005208	Virulence factor SrfB; Region: SrfB; pfam07520
862965005209	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
862965005210	Putative bacterial virulence factor; Region: Virul_Fac; pfam10139
862965005211	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
862965005212	metal ion-dependent adhesion site (MIDAS); other site
862965005213	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
862965005214	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
862965005215	Walker A/P-loop; other site
862965005216	ATP binding site [chemical binding]; other site
862965005217	Q-loop/lid; other site
862965005218	ABC transporter signature motif; other site
862965005219	Walker B; other site
862965005220	D-loop; other site
862965005221	H-loop/switch region; other site
862965005222	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
862965005223	FtsX-like permease family; Region: FtsX; pfam02687
862965005224	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
862965005225	Uncharacterized conserved protein [Function unknown]; Region: COG1262
862965005226	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
862965005227	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
862965005228	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
862965005229	metal ion-dependent adhesion site (MIDAS); other site
862965005230	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
862965005231	metal ion-dependent adhesion site (MIDAS); other site
862965005232	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
862965005233	DsrC like protein; Region: DsrC; pfam04358
862965005234	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
862965005235	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
862965005236	Ligand Binding Site [chemical binding]; other site
862965005237	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
862965005238	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
862965005239	Ferritin-like domain; Region: Ferritin; pfam00210
862965005240	ferroxidase diiron center [ion binding]; other site
862965005241	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
862965005242	Ferritin-like domain; Region: Ferritin; pfam00210
862965005243	ferroxidase diiron center [ion binding]; other site
862965005244	exonuclease I; Provisional; Region: sbcB; PRK11779
862965005245	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
862965005246	active site
862965005247	catalytic site [active]
862965005248	substrate binding site [chemical binding]; other site
862965005249	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
862965005250	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
862965005251	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
862965005252	P-loop containing region of AAA domain; Region: AAA_29; cl17516
862965005253	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
862965005254	condesin subunit E; Provisional; Region: PRK05256
862965005255	condesin subunit F; Provisional; Region: PRK05260
862965005256	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
862965005257	trimer interface [polypeptide binding]; other site
862965005258	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
862965005259	trimer interface [polypeptide binding]; other site
862965005260	YadA-like C-terminal region; Region: YadA; pfam03895
862965005261	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
862965005262	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
862965005263	ligand binding site [chemical binding]; other site
862965005264	flexible hinge region; other site
862965005265	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
862965005266	putative switch regulator; other site
862965005267	non-specific DNA interactions [nucleotide binding]; other site
862965005268	DNA binding site [nucleotide binding]
862965005269	sequence specific DNA binding site [nucleotide binding]; other site
862965005270	putative cAMP binding site [chemical binding]; other site
862965005271	universal stress protein UspE; Provisional; Region: PRK11175
862965005272	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
862965005273	Ligand Binding Site [chemical binding]; other site
862965005274	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
862965005275	Ligand Binding Site [chemical binding]; other site
862965005276	ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
862965005277	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
862965005278	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
862965005279	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
862965005280	active site
862965005281	interdomain interaction site; other site
862965005282	putative metal-binding site [ion binding]; other site
862965005283	nucleotide binding site [chemical binding]; other site
862965005284	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
862965005285	domain I; other site
862965005286	DNA binding groove [nucleotide binding]
862965005287	phosphate binding site [ion binding]; other site
862965005288	domain II; other site
862965005289	domain III; other site
862965005290	nucleotide binding site [chemical binding]; other site
862965005291	catalytic site [active]
862965005292	domain IV; other site
862965005293	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
862965005294	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
862965005295	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
862965005296	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
862965005297	Transcriptional regulator [Transcription]; Region: LysR; COG0583
862965005298	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
862965005299	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
862965005300	putative effector binding pocket; other site
862965005301	dimerization interface [polypeptide binding]; other site
862965005302	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
862965005303	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
862965005304	active site
862965005305	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
862965005306	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
862965005307	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
862965005308	quinone interaction residues [chemical binding]; other site
862965005309	active site
862965005310	catalytic residues [active]
862965005311	FMN binding site [chemical binding]; other site
862965005312	substrate binding site [chemical binding]; other site
862965005313	putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755
862965005314	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
862965005315	peptide binding site [polypeptide binding]; other site
862965005316	aminopeptidase N; Provisional; Region: pepN; PRK14015
862965005317	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
862965005318	active site
862965005319	Zn binding site [ion binding]; other site
862965005320	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
862965005321	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026
862965005322	ATP-grasp domain; Region: ATP-grasp; pfam02222
862965005323	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
862965005324	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
862965005325	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862965005326	homodimer interface [polypeptide binding]; other site
862965005327	catalytic residue [active]
862965005328	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
862965005329	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
862965005330	trimer interface [polypeptide binding]; other site
862965005331	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
862965005332	trimer interface [polypeptide binding]; other site
862965005333	YadA-like C-terminal region; Region: YadA; pfam03895
862965005334	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
862965005335	MoaE homodimer interface [polypeptide binding]; other site
862965005336	MoaD interaction [polypeptide binding]; other site
862965005337	active site residues [active]
862965005338	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
862965005339	MoaE interaction surface [polypeptide binding]; other site
862965005340	MoeB interaction surface [polypeptide binding]; other site
862965005341	thiocarboxylated glycine; other site
862965005342	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
862965005343	trimer interface [polypeptide binding]; other site
862965005344	dimer interface [polypeptide binding]; other site
862965005345	putative active site [active]
862965005346	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
862965005347	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862965005348	FeS/SAM binding site; other site
862965005349	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
862965005350	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
862965005351	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
862965005352	phosphate binding site [ion binding]; other site
862965005353	putative substrate binding pocket [chemical binding]; other site
862965005354	dimer interface [polypeptide binding]; other site
862965005355	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
862965005356	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
862965005357	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
862965005358	Ligand Binding Site [chemical binding]; other site
862965005359	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
862965005360	active site residue [active]
862965005361	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
862965005362	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
862965005363	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
862965005364	substrate binding pocket [chemical binding]; other site
862965005365	chain length determination region; other site
862965005366	substrate-Mg2+ binding site; other site
862965005367	catalytic residues [active]
862965005368	aspartate-rich region 1; other site
862965005369	active site lid residues [active]
862965005370	aspartate-rich region 2; other site
862965005371	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
862965005372	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
862965005373	TPP-binding site; other site
862965005374	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
862965005375	PYR/PP interface [polypeptide binding]; other site
862965005376	dimer interface [polypeptide binding]; other site
862965005377	TPP binding site [chemical binding]; other site
862965005378	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
862965005379	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
862965005380	23S rRNA binding site [nucleotide binding]; other site
862965005381	L21 binding site [polypeptide binding]; other site
862965005382	L13 binding site [polypeptide binding]; other site
862965005383	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
862965005384	translation initiation factor IF-3; Region: infC; TIGR00168
862965005385	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
862965005386	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
862965005387	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
862965005388	active site
862965005389	phosphate binding residues; other site
862965005390	catalytic residues [active]
862965005391	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
862965005392	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
862965005393	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
862965005394	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
862965005395	active site
862965005396	dimer interface [polypeptide binding]; other site
862965005397	motif 1; other site
862965005398	motif 2; other site
862965005399	motif 3; other site
862965005400	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
862965005401	anticodon binding site; other site
862965005402	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
862965005403	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
862965005404	anthranilate synthase component I; Provisional; Region: PRK13564
862965005405	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
862965005406	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
862965005407	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
862965005408	Glutamine amidotransferase class-I; Region: GATase; pfam00117
862965005409	glutamine binding [chemical binding]; other site
862965005410	catalytic triad [active]
862965005411	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
862965005412	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
862965005413	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
862965005414	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
862965005415	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
862965005416	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
862965005417	active site
862965005418	ribulose/triose binding site [chemical binding]; other site
862965005419	phosphate binding site [ion binding]; other site
862965005420	substrate (anthranilate) binding pocket [chemical binding]; other site
862965005421	product (indole) binding pocket [chemical binding]; other site
862965005422	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
862965005423	active site
862965005424	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
862965005425	malonic semialdehyde reductase; Provisional; Region: PRK10538
862965005426	putative NAD(P) binding site [chemical binding]; other site
862965005427	homotetramer interface [polypeptide binding]; other site
862965005428	homodimer interface [polypeptide binding]; other site
862965005429	active site
862965005430	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
862965005431	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
862965005432	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862965005433	catalytic residue [active]
862965005434	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
862965005435	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
862965005436	substrate binding site [chemical binding]; other site
862965005437	active site
862965005438	catalytic residues [active]
862965005439	heterodimer interface [polypeptide binding]; other site
862965005440	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
862965005441	stringent starvation protein A; Provisional; Region: sspA; PRK09481
862965005442	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
862965005443	C-terminal domain interface [polypeptide binding]; other site
862965005444	putative GSH binding site (G-site) [chemical binding]; other site
862965005445	dimer interface [polypeptide binding]; other site
862965005446	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
862965005447	dimer interface [polypeptide binding]; other site
862965005448	N-terminal domain interface [polypeptide binding]; other site
862965005449	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
862965005450	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
862965005451	23S rRNA interface [nucleotide binding]; other site
862965005452	L3 interface [polypeptide binding]; other site
862965005453	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
862965005454	FAD binding site [chemical binding]; other site
862965005455	NlpC/P60 family; Region: NLPC_P60; pfam00877
862965005456	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
862965005457	IHF dimer interface [polypeptide binding]; other site
862965005458	IHF - DNA interface [nucleotide binding]; other site
862965005459	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
862965005460	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
862965005461	putative tRNA-binding site [nucleotide binding]; other site
862965005462	B3/4 domain; Region: B3_4; pfam03483
862965005463	tRNA synthetase B5 domain; Region: B5; smart00874
862965005464	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
862965005465	dimer interface [polypeptide binding]; other site
862965005466	motif 1; other site
862965005467	motif 3; other site
862965005468	motif 2; other site
862965005469	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
862965005470	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
862965005471	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
862965005472	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
862965005473	dimer interface [polypeptide binding]; other site
862965005474	motif 1; other site
862965005475	active site
862965005476	motif 2; other site
862965005477	motif 3; other site
862965005478	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
862965005479	Phosphotransferase enzyme family; Region: APH; pfam01636
862965005480	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
862965005481	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
862965005482	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
862965005483	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
862965005484	ligand binding site [chemical binding]; other site
862965005485	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
862965005486	putative inner membrane peptidase; Provisional; Region: PRK11778
862965005487	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
862965005488	tandem repeat interface [polypeptide binding]; other site
862965005489	oligomer interface [polypeptide binding]; other site
862965005490	active site residues [active]
862965005491	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
862965005492	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
862965005493	putative dimer interface [polypeptide binding]; other site
862965005494	putative anticodon binding site; other site
862965005495	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
862965005496	homodimer interface [polypeptide binding]; other site
862965005497	motif 1; other site
862965005498	motif 2; other site
862965005499	active site
862965005500	motif 3; other site
862965005501	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
862965005502	active site clefts [active]
862965005503	zinc binding site [ion binding]; other site
862965005504	dimer interface [polypeptide binding]; other site
862965005505	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
862965005506	AAA domain; Region: AAA_26; pfam13500
862965005507	YcgL domain; Region: YcgL; cl01189
862965005508	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
862965005509	catalytic core [active]
862965005510	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
862965005511	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
862965005512	active site
862965005513	substrate binding site [chemical binding]; other site
862965005514	metal binding site [ion binding]; metal-binding site
862965005515	dihydropteroate synthase; Region: DHPS; TIGR01496
862965005516	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
862965005517	substrate binding pocket [chemical binding]; other site
862965005518	dimer interface [polypeptide binding]; other site
862965005519	inhibitor binding site; inhibition site
862965005520	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
862965005521	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862965005522	Walker A motif; other site
862965005523	ATP binding site [chemical binding]; other site
862965005524	Walker B motif; other site
862965005525	arginine finger; other site
862965005526	Peptidase family M41; Region: Peptidase_M41; pfam01434
862965005527	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
862965005528	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862965005529	S-adenosylmethionine binding site [chemical binding]; other site
862965005530	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
862965005531	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
862965005532	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
862965005533	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
862965005534	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
862965005535	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
862965005536	amidophosphoribosyltransferase; Provisional; Region: PRK09246
862965005537	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
862965005538	active site
862965005539	tetramer interface [polypeptide binding]; other site
862965005540	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862965005541	active site
862965005542	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
862965005543	Colicin V production protein; Region: Colicin_V; cl00567
862965005544	hypothetical protein; Provisional; Region: PRK01816
862965005545	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
862965005546	propionate/acetate kinase; Provisional; Region: PRK12379
862965005547	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
862965005548	ribonuclease D; Provisional; Region: PRK10829
862965005549	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
862965005550	catalytic site [active]
862965005551	putative active site [active]
862965005552	putative substrate binding site [chemical binding]; other site
862965005553	Helicase and RNase D C-terminal; Region: HRDC; smart00341
862965005554	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
862965005555	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
862965005556	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
862965005557	acyl-activating enzyme (AAE) consensus motif; other site
862965005558	putative AMP binding site [chemical binding]; other site
862965005559	putative active site [active]
862965005560	putative CoA binding site [chemical binding]; other site
862965005561	Outer membrane lipoprotein Slp family; Region: Slp; cl01164
862965005562	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
862965005563	Glycoprotease family; Region: Peptidase_M22; pfam00814
862965005564	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
862965005565	DEAD/DEAH box helicase; Region: DEAD; pfam00270
862965005566	ATP binding site [chemical binding]; other site
862965005567	DEAD_2; Region: DEAD_2; pfam06733
862965005568	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862965005569	nucleotide binding region [chemical binding]; other site
862965005570	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
862965005571	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
862965005572	Mg++ binding site [ion binding]; other site
862965005573	putative catalytic motif [active]
862965005574	substrate binding site [chemical binding]; other site
862965005575	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
862965005576	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
862965005577	inhibitor-cofactor binding pocket; inhibition site
862965005578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862965005579	catalytic residue [active]
862965005580	PII uridylyl-transferase; Provisional; Region: glnD; PRK01759
862965005581	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
862965005582	metal binding triad; other site
862965005583	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
862965005584	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
862965005585	Zn2+ binding site [ion binding]; other site
862965005586	Mg2+ binding site [ion binding]; other site
862965005587	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
862965005588	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
862965005589	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
862965005590	active site
862965005591	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
862965005592	hypothetical protein; Provisional; Region: PRK05248
862965005593	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
862965005594	Transglycosylase; Region: Transgly; pfam00912
862965005595	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
862965005596	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
862965005597	Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470
862965005598	Predicted membrane protein [Function unknown]; Region: COG4393
862965005599	Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080
862965005600	Uncharacterized conserved protein [Function unknown]; Region: COG3350
862965005601	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
862965005602	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
862965005603	FtsX-like permease family; Region: FtsX; pfam02687
862965005604	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
862965005605	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
862965005606	FtsX-like permease family; Region: FtsX; pfam02687
862965005607	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
862965005608	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
862965005609	Walker A/P-loop; other site
862965005610	ATP binding site [chemical binding]; other site
862965005611	Q-loop/lid; other site
862965005612	ABC transporter signature motif; other site
862965005613	Walker B; other site
862965005614	D-loop; other site
862965005615	H-loop/switch region; other site
862965005616	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
862965005617	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
862965005618	catalytic residues [active]
862965005619	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
862965005620	Cytochrome c; Region: Cytochrom_C; cl11414
862965005621	ATP-grasp domain; Region: ATP-grasp_4; cl17255
862965005622	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
862965005623	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
862965005624	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
862965005625	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
862965005626	Walker A/P-loop; other site
862965005627	ATP binding site [chemical binding]; other site
862965005628	Q-loop/lid; other site
862965005629	ABC transporter signature motif; other site
862965005630	Walker B; other site
862965005631	D-loop; other site
862965005632	H-loop/switch region; other site
862965005633	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
862965005634	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
862965005635	ABC-ATPase subunit  interface; other site
862965005636	dimer interface [polypeptide binding]; other site
862965005637	putative PBP binding regions; other site
862965005638	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
862965005639	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
862965005640	intersubunit interface [polypeptide binding]; other site
862965005641	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
862965005642	lytic murein transglycosylase; Region: MltB_2; TIGR02283
862965005643	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
862965005644	N-acetyl-D-glucosamine binding site [chemical binding]; other site
862965005645	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
862965005646	GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195
862965005647	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
862965005648	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
862965005649	active site
862965005650	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
862965005651	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
862965005652	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
862965005653	DNA binding site [nucleotide binding]
862965005654	domain linker motif; other site
862965005655	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
862965005656	dimerization interface [polypeptide binding]; other site
862965005657	ligand binding site [chemical binding]; other site
862965005658	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
862965005659	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
862965005660	Transcriptional regulators [Transcription]; Region: MarR; COG1846
862965005661	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
862965005662	ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748
862965005663	dsDNA-mimic protein; Reviewed; Region: PRK05094
862965005664	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
862965005665	dimerization interface [polypeptide binding]; other site
862965005666	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
862965005667	ATP binding site [chemical binding]; other site
862965005668	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
862965005669	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
862965005670	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
862965005671	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
862965005672	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
862965005673	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
862965005674	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
862965005675	DNA binding residues [nucleotide binding]
862965005676	dimer interface [polypeptide binding]; other site
862965005677	putative metal binding site [ion binding]; other site
862965005678	ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
862965005679	cobalt transport protein CbiM; Validated; Region: PRK06265
862965005680	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
862965005681	Cobalt transport protein; Region: CbiQ; cl00463
862965005682	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
862965005683	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
862965005684	Walker A/P-loop; other site
862965005685	ATP binding site [chemical binding]; other site
862965005686	Q-loop/lid; other site
862965005687	ABC transporter signature motif; other site
862965005688	Walker B; other site
862965005689	D-loop; other site
862965005690	H-loop/switch region; other site
862965005691	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
862965005692	molybdopterin cofactor binding site; other site
862965005693	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
862965005694	molybdopterin cofactor binding site; other site
862965005695	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
862965005696	Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067
862965005697	nickel binding site [ion binding]; other site
862965005698	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
862965005699	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
862965005700	hydrogenase 4 subunit H; Validated; Region: PRK08222
862965005701	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
862965005702	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
862965005703	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
862965005704	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
862965005705	hydrogenase 4 subunit F; Validated; Region: PRK06458
862965005706	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
862965005707	hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492
862965005708	hydrogenase 4 subunit D; Validated; Region: PRK06525
862965005709	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
862965005710	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
862965005711	NADH dehydrogenase; Region: NADHdh; cl00469
862965005712	hydrogenase 4 subunit B; Validated; Region: PRK06521
862965005713	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
862965005714	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
862965005715	4Fe-4S binding domain; Region: Fer4; pfam00037
862965005716	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
862965005717	Acylphosphatase; Region: Acylphosphatase; pfam00708
862965005718	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
862965005719	HypF finger; Region: zf-HYPF; pfam07503
862965005720	HypF finger; Region: zf-HYPF; pfam07503
862965005721	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
862965005722	Predicted membrane protein [Function unknown]; Region: COG2431
862965005723	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
862965005724	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
862965005725	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
862965005726	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
862965005727	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
862965005728	protein binding site [polypeptide binding]; other site
862965005729	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
862965005730	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
862965005731	excinuclease ABC subunit B; Provisional; Region: PRK05298
862965005732	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
862965005733	ATP-binding site [chemical binding]; other site
862965005734	ATP binding site [chemical binding]; other site
862965005735	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862965005736	nucleotide binding region [chemical binding]; other site
862965005737	ATP-binding site [chemical binding]; other site
862965005738	Ultra-violet resistance protein B; Region: UvrB; pfam12344
862965005739	UvrB/uvrC motif; Region: UVR; pfam02151
862965005740	TIGR01619 family protein; Region: hyp_HI0040
862965005741	Family of unknown function (DUF695); Region: DUF695; pfam05117
862965005742	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
862965005743	putative catalytic site [active]
862965005744	putative phosphate binding site [ion binding]; other site
862965005745	active site
862965005746	metal binding site A [ion binding]; metal-binding site
862965005747	DNA binding site [nucleotide binding]
862965005748	putative AP binding site [nucleotide binding]; other site
862965005749	putative metal binding site B [ion binding]; other site
862965005750	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
862965005751	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
862965005752	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
862965005753	active site
862965005754	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
862965005755	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
862965005756	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
862965005757	putative active site [active]
862965005758	catalytic site [active]
862965005759	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
862965005760	putative active site [active]
862965005761	catalytic site [active]
862965005762	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
862965005763	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
862965005764	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
862965005765	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
862965005766	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
862965005767	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
862965005768	putative active site [active]
862965005769	putative substrate binding site [chemical binding]; other site
862965005770	putative cosubstrate binding site; other site
862965005771	catalytic site [active]
862965005772	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
862965005773	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
862965005774	hinge; other site
862965005775	active site
862965005776	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
862965005777	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862965005778	putative substrate translocation pore; other site
862965005779	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
862965005780	homodecamer interface [polypeptide binding]; other site
862965005781	GTP cyclohydrolase I; Provisional; Region: PLN03044
862965005782	active site
862965005783	putative catalytic site residues [active]
862965005784	zinc binding site [ion binding]; other site
862965005785	GTP-CH-I/GFRP interaction surface; other site
862965005786	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
862965005787	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
862965005788	dimer interface [polypeptide binding]; other site
862965005789	putative functional site; other site
862965005790	putative MPT binding site; other site
862965005791	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
862965005792	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
862965005793	ATP binding site [chemical binding]; other site
862965005794	substrate interface [chemical binding]; other site
862965005795	putative inner membrane protein; Provisional; Region: PRK11099
862965005796	hypothetical protein; Provisional; Region: PRK11018
862965005797	CPxP  motif; other site
862965005798	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
862965005799	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
862965005800	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
862965005801	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
862965005802	ligand binding site [chemical binding]; other site
862965005803	homodimer interface [polypeptide binding]; other site
862965005804	NAD(P) binding site [chemical binding]; other site
862965005805	trimer interface B [polypeptide binding]; other site
862965005806	trimer interface A [polypeptide binding]; other site
862965005807	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
862965005808	protease TldD; Provisional; Region: tldD; PRK10735
862965005809	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
862965005810	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
862965005811	putative SAM binding site [chemical binding]; other site
862965005812	putative homodimer interface [polypeptide binding]; other site
862965005813	LppC putative lipoprotein; Region: LppC; pfam04348
862965005814	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
862965005815	putative ligand binding site [chemical binding]; other site
862965005816	TIGR00252 family protein; Region: TIGR00252
862965005817	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
862965005818	dimer interface [polypeptide binding]; other site
862965005819	active site
862965005820	outer membrane lipoprotein; Provisional; Region: PRK11023
862965005821	BON domain; Region: BON; pfam04972
862965005822	BON domain; Region: BON; cl02771
862965005823	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
862965005824	ATP cone domain; Region: ATP-cone; pfam03477
862965005825	Class I ribonucleotide reductase; Region: RNR_I; cd01679
862965005826	active site
862965005827	dimer interface [polypeptide binding]; other site
862965005828	catalytic residues [active]
862965005829	effector binding site; other site
862965005830	R2 peptide binding site; other site
862965005831	Domain of unknown function (DUF4393); Region: DUF4393; pfam14337
862965005832	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
862965005833	dimer interface [polypeptide binding]; other site
862965005834	putative radical transfer pathway; other site
862965005835	diiron center [ion binding]; other site
862965005836	tyrosyl radical; other site
862965005837	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
862965005838	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
862965005839	dimer interface [polypeptide binding]; other site
862965005840	putative anticodon binding site; other site
862965005841	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
862965005842	motif 1; other site
862965005843	active site
862965005844	motif 2; other site
862965005845	motif 3; other site
862965005846	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
862965005847	substrate binding site [chemical binding]; other site
862965005848	zinc-binding site [ion binding]; other site
862965005849	cytosine deaminase; Provisional; Region: PRK09230
862965005850	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
862965005851	active site
862965005852	nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484
862965005853	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
862965005854	Na binding site [ion binding]; other site
862965005855	putative substrate binding site [chemical binding]; other site
862965005856	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
862965005857	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
862965005858	putative active site [active]
862965005859	biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724
862965005860	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
862965005861	sensor histidine kinase inhibitor, KipI family; Region: TIGR00370
862965005862	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
862965005863	AMP binding site [chemical binding]; other site
862965005864	metal binding site [ion binding]; metal-binding site
862965005865	active site
862965005866	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
862965005867	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
862965005868	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
862965005869	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
862965005870	multifunctional aminopeptidase A; Provisional; Region: PRK00913
862965005871	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
862965005872	interface (dimer of trimers) [polypeptide binding]; other site
862965005873	Substrate-binding/catalytic site; other site
862965005874	Zn-binding sites [ion binding]; other site
862965005875	hypothetical protein; Provisional; Region: PRK05421
862965005876	putative catalytic site [active]
862965005877	putative metal binding site [ion binding]; other site
862965005878	putative phosphate binding site [ion binding]; other site
862965005879	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
862965005880	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
862965005881	Hemerythrin-like domain; Region: Hr-like; cd12108
862965005882	Fe binding site [ion binding]; other site
862965005883	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
862965005884	Sulfatase; Region: Sulfatase; pfam00884
862965005885	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
862965005886	Malic enzyme, N-terminal domain; Region: malic; pfam00390
862965005887	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
862965005888	putative NAD(P) binding site [chemical binding]; other site
862965005889	Domain of unknown function (DUF1919); Region: DUF1919; pfam08942
862965005890	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
862965005891	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
862965005892	RNA binding surface [nucleotide binding]; other site
862965005893	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
862965005894	active site
862965005895	uracil binding [chemical binding]; other site
862965005896	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
862965005897	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862965005898	putative substrate translocation pore; other site
862965005899	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
862965005900	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
862965005901	fructokinase; Reviewed; Region: PRK09557
862965005902	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
862965005903	nucleotide binding site [chemical binding]; other site
862965005904	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
862965005905	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
862965005906	active site
862965005907	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
862965005908	dimerization interface [polypeptide binding]; other site
862965005909	active site
862965005910	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
862965005911	Ligand Binding Site [chemical binding]; other site
862965005912	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
862965005913	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862965005914	ATP binding site [chemical binding]; other site
862965005915	Mg2+ binding site [ion binding]; other site
862965005916	G-X-G motif; other site
862965005917	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
862965005918	anchoring element; other site
862965005919	dimer interface [polypeptide binding]; other site
862965005920	ATP binding site [chemical binding]; other site
862965005921	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
862965005922	active site
862965005923	putative metal-binding site [ion binding]; other site
862965005924	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
862965005925	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
862965005926	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
862965005927	Multicopper oxidase; Region: Cu-oxidase; pfam00394
862965005928	DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062
862965005929	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
862965005930	CAP-like domain; other site
862965005931	active site
862965005932	primary dimer interface [polypeptide binding]; other site
862965005933	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
862965005934	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
862965005935	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
862965005936	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
862965005937	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
862965005938	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
862965005939	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
862965005940	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
862965005941	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
862965005942	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
862965005943	dimerization interface 3.5A [polypeptide binding]; other site
862965005944	active site
862965005945	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
862965005946	5S rRNA interface [nucleotide binding]; other site
862965005947	CTC domain interface [polypeptide binding]; other site
862965005948	L16 interface [polypeptide binding]; other site
862965005949	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
862965005950	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
862965005951	Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms]; Region: COG3513
862965005952	CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643
862965005953	CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720
862965005954	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
862965005955	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
862965005956	Lumazine binding domain; Region: Lum_binding; pfam00677
862965005957	Lumazine binding domain; Region: Lum_binding; pfam00677
862965005958	multidrug efflux protein; Reviewed; Region: PRK01766
862965005959	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
862965005960	cation binding site [ion binding]; other site
862965005961	ribonuclease G; Provisional; Region: PRK11712
862965005962	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
862965005963	homodimer interface [polypeptide binding]; other site
862965005964	oligonucleotide binding site [chemical binding]; other site
862965005965	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
862965005966	Na binding site [ion binding]; other site
862965005967	Methyltransferase domain; Region: Methyltransf_23; pfam13489
862965005968	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862965005969	S-adenosylmethionine binding site [chemical binding]; other site
862965005970	putative lyase; Provisional; Region: PRK09687
862965005971	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
862965005972	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
862965005973	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
862965005974	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
862965005975	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
862965005976	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
862965005977	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
862965005978	dimerization interface [polypeptide binding]; other site
862965005979	substrate binding pocket [chemical binding]; other site
862965005980	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
862965005981	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
862965005982	homodimer interface [polypeptide binding]; other site
862965005983	substrate-cofactor binding pocket; other site
862965005984	catalytic residue [active]
862965005985	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
862965005986	oxaloacetate decarboxylase; Provisional; Region: PRK14040
862965005987	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
862965005988	active site
862965005989	catalytic residues [active]
862965005990	metal binding site [ion binding]; metal-binding site
862965005991	homodimer binding site [polypeptide binding]; other site
862965005992	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
862965005993	carboxyltransferase (CT) interaction site; other site
862965005994	biotinylation site [posttranslational modification]; other site
862965005995	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
862965005996	2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633
862965005997	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
862965005998	putative substrate translocation pore; other site
862965005999	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
862965006000	putative acyl-acceptor binding pocket; other site
862965006001	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
862965006002	acyl-activating enzyme (AAE) consensus motif; other site
862965006003	AMP binding site [chemical binding]; other site
862965006004	active site
862965006005	CoA binding site [chemical binding]; other site
862965006006	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
862965006007	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
862965006008	DNA binding residues [nucleotide binding]
862965006009	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
862965006010	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
862965006011	peptide binding site [polypeptide binding]; other site
862965006012	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
862965006013	oligopeptidase A; Provisional; Region: PRK10911
862965006014	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
862965006015	active site
862965006016	Zn binding site [ion binding]; other site
862965006017	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
862965006018	16S/18S rRNA binding site [nucleotide binding]; other site
862965006019	S13e-L30e interaction site [polypeptide binding]; other site
862965006020	25S rRNA binding site [nucleotide binding]; other site
862965006021	molybdenum transport protein ModD; Provisional; Region: PRK06096
862965006022	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
862965006023	dimerization interface [polypeptide binding]; other site
862965006024	active site
862965006025	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
862965006026	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
862965006027	Walker A/P-loop; other site
862965006028	ATP binding site [chemical binding]; other site
862965006029	Q-loop/lid; other site
862965006030	ABC transporter signature motif; other site
862965006031	Walker B; other site
862965006032	D-loop; other site
862965006033	H-loop/switch region; other site
862965006034	potential frameshift: common BLAST hit: gi|251793366|ref|YP_003008094.1| FecCD family ABC transporter permease
862965006035	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
862965006036	putative PBP binding regions; other site
862965006037	ABC-ATPase subunit  interface; other site
862965006038	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
862965006039	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
862965006040	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
862965006041	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
862965006042	putative metal binding site [ion binding]; other site
862965006043	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
862965006044	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
862965006045	N-terminal plug; other site
862965006046	ligand-binding site [chemical binding]; other site
862965006047	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
862965006048	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
862965006049	putative ribose interaction site [chemical binding]; other site
862965006050	putative ADP binding site [chemical binding]; other site
862965006051	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
862965006052	active site
862965006053	nucleotide binding site [chemical binding]; other site
862965006054	HIGH motif; other site
862965006055	KMSKS motif; other site
862965006056	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
862965006057	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
862965006058	putative acyl-acceptor binding pocket; other site
862965006059	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
862965006060	Uncharacterized conserved protein [Function unknown]; Region: COG0327
862965006061	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
862965006062	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
862965006063	NAD binding site [chemical binding]; other site
862965006064	homotetramer interface [polypeptide binding]; other site
862965006065	homodimer interface [polypeptide binding]; other site
862965006066	substrate binding site [chemical binding]; other site
862965006067	active site
862965006068	exoribonuclease II; Provisional; Region: PRK05054
862965006069	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
862965006070	RNB domain; Region: RNB; pfam00773
862965006071	S1 RNA binding domain; Region: S1; pfam00575
862965006072	RNA binding site [nucleotide binding]; other site
862965006073	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
862965006074	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
862965006075	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
862965006076	active site turn [active]
862965006077	phosphorylation site [posttranslational modification]
862965006078	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
862965006079	putative catalytic site [active]
862965006080	putative metal binding site [ion binding]; other site
862965006081	putative phosphate binding site [ion binding]; other site
862965006082	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
862965006083	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
862965006084	4-alpha-glucanotransferase; Provisional; Region: PRK14508
862965006085	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
862965006086	DNA-binding site [nucleotide binding]; DNA binding site
862965006087	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
862965006088	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
862965006089	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
862965006090	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
862965006091	gating phenylalanine in ion channel; other site
862965006092	seryl-tRNA synthetase; Provisional; Region: PRK05431
862965006093	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
862965006094	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
862965006095	dimer interface [polypeptide binding]; other site
862965006096	active site
862965006097	motif 1; other site
862965006098	motif 2; other site
862965006099	motif 3; other site
862965006100	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841
862965006101	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
862965006102	EamA-like transporter family; Region: EamA; pfam00892
862965006103	Predicted membrane protein [Function unknown]; Region: COG2860
862965006104	UPF0126 domain; Region: UPF0126; pfam03458
862965006105	UPF0126 domain; Region: UPF0126; pfam03458
862965006106	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
862965006107	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
862965006108	putative catalytic cysteine [active]
862965006109	Protein of unknown function (DUF808); Region: DUF808; pfam05661
862965006110	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
862965006111	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
862965006112	Walker A motif; other site
862965006113	ATP binding site [chemical binding]; other site
862965006114	Walker B motif; other site
862965006115	arginine finger; other site
862965006116	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
862965006117	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
862965006118	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
862965006119	active site
862965006120	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
862965006121	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
862965006122	putative acyl-acceptor binding pocket; other site
862965006123	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
862965006124	hypothetical protein; Provisional; Region: PRK10621
862965006125	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
862965006126	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
862965006127	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
862965006128	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
862965006129	Tetramer interface [polypeptide binding]; other site
862965006130	active site
862965006131	FMN-binding site [chemical binding]; other site
862965006132	hypothetical protein; Provisional; Region: PRK11281
862965006133	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
862965006134	Mechanosensitive ion channel; Region: MS_channel; pfam00924
862965006135	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
862965006136	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
862965006137	acyl-activating enzyme (AAE) consensus motif; other site
862965006138	putative AMP binding site [chemical binding]; other site
862965006139	putative active site [active]
862965006140	putative CoA binding site [chemical binding]; other site
862965006141	replication initiation regulator SeqA; Provisional; Region: PRK11187
862965006142	acyl-CoA esterase; Provisional; Region: PRK10673
862965006143	PGAP1-like protein; Region: PGAP1; pfam07819
862965006144	flavodoxin FldA; Validated; Region: PRK09267
862965006145	ferric uptake regulator; Provisional; Region: fur; PRK09462
862965006146	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
862965006147	metal binding site 2 [ion binding]; metal-binding site
862965006148	putative DNA binding helix; other site
862965006149	metal binding site 1 [ion binding]; metal-binding site
862965006150	dimer interface [polypeptide binding]; other site
862965006151	structural Zn2+ binding site [ion binding]; other site
862965006152	argininosuccinate synthase; Validated; Region: PRK05370
862965006153	argininosuccinate synthase; Provisional; Region: PRK13820
862965006154	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
862965006155	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
862965006156	putative NAD(P) binding site [chemical binding]; other site
862965006157	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
862965006158	ATP binding site [chemical binding]; other site
862965006159	active site
862965006160	substrate binding site [chemical binding]; other site
862965006161	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
862965006162	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
862965006163	G1 box; other site
862965006164	putative GEF interaction site [polypeptide binding]; other site
862965006165	GTP/Mg2+ binding site [chemical binding]; other site
862965006166	Switch I region; other site
862965006167	G2 box; other site
862965006168	G3 box; other site
862965006169	Switch II region; other site
862965006170	G4 box; other site
862965006171	G5 box; other site
862965006172	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
862965006173	Predicted periplasmic protein [Function unknown]; Region: COG3698
862965006174	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
862965006175	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
862965006176	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
862965006177	tRNA; other site
862965006178	putative tRNA binding site [nucleotide binding]; other site
862965006179	putative NADP binding site [chemical binding]; other site
862965006180	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
862965006181	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
862965006182	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
862965006183	S-adenosylmethionine binding site [chemical binding]; other site
862965006184	DNA methylase; Region: N6_N4_Mtase; cl17433
862965006185	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
862965006186	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
862965006187	uncharacterized domain; Region: TIGR00702
862965006188	YcaO-like family; Region: YcaO; pfam02624
862965006189	DNA gyrase subunit A; Validated; Region: PRK05560
862965006190	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
862965006191	CAP-like domain; other site
862965006192	active site
862965006193	primary dimer interface [polypeptide binding]; other site
862965006194	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
862965006195	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
862965006196	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
862965006197	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
862965006198	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
862965006199	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
862965006200	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
862965006201	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
862965006202	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
862965006203	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
862965006204	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
862965006205	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
862965006206	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
862965006207	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965006208	Walker A/P-loop; other site
862965006209	ATP binding site [chemical binding]; other site
862965006210	Q-loop/lid; other site
862965006211	ABC transporter signature motif; other site
862965006212	Walker B; other site
862965006213	D-loop; other site
862965006214	H-loop/switch region; other site
862965006215	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965006216	Walker A/P-loop; other site
862965006217	ATP binding site [chemical binding]; other site
862965006218	Q-loop/lid; other site
862965006219	ABC transporter signature motif; other site
862965006220	Walker B; other site
862965006221	D-loop; other site
862965006222	H-loop/switch region; other site
862965006223	serine/threonine transporter SstT; Provisional; Region: PRK13628
862965006224	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
862965006225	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
862965006226	NlpC/P60 family; Region: NLPC_P60; pfam00877
862965006227	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
862965006228	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
862965006229	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
862965006230	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
862965006231	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
862965006232	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
862965006233	E3 interaction surface; other site
862965006234	lipoyl attachment site [posttranslational modification]; other site
862965006235	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
862965006236	E3 interaction surface; other site
862965006237	lipoyl attachment site [posttranslational modification]; other site
862965006238	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
862965006239	E3 interaction surface; other site
862965006240	lipoyl attachment site [posttranslational modification]; other site
862965006241	e3 binding domain; Region: E3_binding; pfam02817
862965006242	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
862965006243	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
862965006244	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
862965006245	dimer interface [polypeptide binding]; other site
862965006246	TPP-binding site [chemical binding]; other site
862965006247	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
862965006248	active site
862965006249	dimer interfaces [polypeptide binding]; other site
862965006250	catalytic residues [active]
862965006251	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
862965006252	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
862965006253	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
862965006254	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
862965006255	nucleotide binding site [chemical binding]; other site
862965006256	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
862965006257	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
862965006258	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
862965006259	homodimer interface [polypeptide binding]; other site
862965006260	substrate-cofactor binding pocket; other site
862965006261	pyridoxal 5'-phosphate binding site [chemical binding]; other site
862965006262	catalytic residue [active]
862965006263	chaperone protein DnaJ; Provisional; Region: PRK10767
862965006264	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
862965006265	HSP70 interaction site [polypeptide binding]; other site
862965006266	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
862965006267	substrate binding site [polypeptide binding]; other site
862965006268	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
862965006269	Zn binding sites [ion binding]; other site
862965006270	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
862965006271	dimer interface [polypeptide binding]; other site
862965006272	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
862965006273	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965006274	Walker A/P-loop; other site
862965006275	ATP binding site [chemical binding]; other site
862965006276	Q-loop/lid; other site
862965006277	ABC transporter signature motif; other site
862965006278	Walker B; other site
862965006279	D-loop; other site
862965006280	H-loop/switch region; other site
862965006281	TOBE domain; Region: TOBE; pfam03459
862965006282	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
862965006283	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965006284	dimer interface [polypeptide binding]; other site
862965006285	conserved gate region; other site
862965006286	putative PBP binding loops; other site
862965006287	ABC-ATPase subunit interface; other site
862965006288	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
862965006289	molybdenum ABC transporter, periplasmic molybdate-binding protein; Region: modA; TIGR01256
862965006290	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
862965006291	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
862965006292	molybdenum-pterin binding domain; Region: Mop; TIGR00638
862965006293	5'-nucleotidase; Provisional; Region: PRK03826
862965006294	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
862965006295	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
862965006296	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
862965006297	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
862965006298	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
862965006299	catalytic motif [active]
862965006300	Zn binding site [ion binding]; other site
862965006301	RibD C-terminal domain; Region: RibD_C; cl17279
862965006302	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
862965006303	ATP cone domain; Region: ATP-cone; pfam03477
862965006304	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
862965006305	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
862965006306	Protein of unknown function (DUF2572); Region: DUF2572; pfam10833
862965006307	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
862965006308	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
862965006309	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
862965006310	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
862965006311	active site
862965006312	dimerization interface [polypeptide binding]; other site
862965006313	biotin synthase; Region: bioB; TIGR00433
862965006314	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
862965006315	FeS/SAM binding site; other site
862965006316	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
862965006317	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
862965006318	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
862965006319	Walker A/P-loop; other site
862965006320	ATP binding site [chemical binding]; other site
862965006321	Q-loop/lid; other site
862965006322	ABC transporter signature motif; other site
862965006323	Walker B; other site
862965006324	D-loop; other site
862965006325	H-loop/switch region; other site
862965006326	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
862965006327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
862965006328	dimer interface [polypeptide binding]; other site
862965006329	conserved gate region; other site
862965006330	putative PBP binding loops; other site
862965006331	ABC-ATPase subunit interface; other site
862965006332	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
862965006333	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
862965006334	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
862965006335	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
862965006336	putative GSH binding site [chemical binding]; other site
862965006337	catalytic residues [active]
862965006338	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
862965006339	Repair protein; Region: Repair_PSII; pfam04536
862965006340	Repair protein; Region: Repair_PSII; cl01535
862965006341	LemA family; Region: LemA; pfam04011
862965006342	outer membrane protein A; Reviewed; Region: PRK10808
862965006343	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
862965006344	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
862965006345	ligand binding site [chemical binding]; other site
862965006346	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
862965006347	FAD binding domain; Region: FAD_binding_4; pfam01565
862965006348	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
862965006349	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
862965006350	CoenzymeA binding site [chemical binding]; other site
862965006351	subunit interaction site [polypeptide binding]; other site
862965006352	PHB binding site; other site
862965006353	ferrochelatase; Reviewed; Region: hemH; PRK00035
862965006354	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
862965006355	C-terminal domain interface [polypeptide binding]; other site
862965006356	active site
862965006357	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
862965006358	active site
862965006359	N-terminal domain interface [polypeptide binding]; other site
862965006360	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
862965006361	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
862965006362	trimer interface [polypeptide binding]; other site
862965006363	eyelet of channel; other site
862965006364	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
862965006365	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
862965006366	HIGH motif; other site
862965006367	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
862965006368	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
862965006369	active site
862965006370	KMSKS motif; other site
862965006371	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
862965006372	tRNA binding surface [nucleotide binding]; other site
862965006373	anticodon binding site; other site
862965006374	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
862965006375	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
862965006376	Protein of unknown function (DUF1375); Region: DUF1375; cl11456
862965006377	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
862965006378	DNA polymerase III subunit chi; Validated; Region: PRK05728
862965006379	fumarate hydratase; Reviewed; Region: fumC; PRK00485
862965006380	Class II fumarases; Region: Fumarase_classII; cd01362
862965006381	active site
862965006382	tetramer interface [polypeptide binding]; other site
862965006383	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
862965006384	ATP-grasp domain; Region: ATP-grasp_4; cl17255
862965006385	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
862965006386	GSH binding site [chemical binding]; other site
862965006387	catalytic residues [active]
862965006388	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
862965006389	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
862965006390	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
862965006391	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
862965006392	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
862965006393	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
862965006394	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
862965006395	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
862965006396	PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439
862965006397	HPr interaction site; other site
862965006398	glycerol kinase (GK) interaction site [polypeptide binding]; other site
862965006399	active site
862965006400	phosphorylation site [posttranslational modification]
862965006401	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
862965006402	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
862965006403	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
862965006404	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
862965006405	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
862965006406	dimerization domain swap beta strand [polypeptide binding]; other site
862965006407	regulatory protein interface [polypeptide binding]; other site
862965006408	active site
862965006409	regulatory phosphorylation site [posttranslational modification]; other site
862965006410	GTPase RsgA; Reviewed; Region: PRK12288
862965006411	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
862965006412	RNA binding site [nucleotide binding]; other site
862965006413	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
862965006414	GTPase/Zn-binding domain interface [polypeptide binding]; other site
862965006415	GTP/Mg2+ binding site [chemical binding]; other site
862965006416	G4 box; other site
862965006417	G5 box; other site
862965006418	G1 box; other site
862965006419	Switch I region; other site
862965006420	G2 box; other site
862965006421	G3 box; other site
862965006422	Switch II region; other site
862965006423	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
862965006424	catalytic site [active]
862965006425	putative active site [active]
862965006426	putative substrate binding site [chemical binding]; other site
862965006427	dimer interface [polypeptide binding]; other site
862965006428	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
862965006429	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
862965006430	active site
862965006431	metal binding site [ion binding]; metal-binding site
862965006432	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
862965006433	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
862965006434	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
862965006435	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
862965006436	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
862965006437	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
862965006438	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
862965006439	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
862965006440	ATP binding site [chemical binding]; other site
862965006441	Mg2+ binding site [ion binding]; other site
862965006442	G-X-G motif; other site
862965006443	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
862965006444	ATP binding site [chemical binding]; other site
862965006445	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
862965006446	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
862965006447	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
862965006448	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
862965006449	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
862965006450	metal binding triad; other site
862965006451	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
862965006452	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
862965006453	metal binding triad; other site
862965006454	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
862965006455	glutamate racemase; Provisional; Region: PRK00865
862965006456	aspartate racemase; Region: asp_race; TIGR00035
862965006457	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
862965006458	Pathogenicity locus; Region: Cdd1; pfam11731
862965006459	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
862965006460	generic binding surface II; other site
862965006461	ssDNA binding site; other site
862965006462	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
862965006463	ATP binding site [chemical binding]; other site
862965006464	putative Mg++ binding site [ion binding]; other site
862965006465	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
862965006466	nucleotide binding region [chemical binding]; other site
862965006467	ATP-binding site [chemical binding]; other site
862965006468	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
862965006469	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
862965006470	Zn2+ binding site [ion binding]; other site
862965006471	Mg2+ binding site [ion binding]; other site
862965006472	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
862965006473	synthetase active site [active]
862965006474	NTP binding site [chemical binding]; other site
862965006475	metal binding site [ion binding]; metal-binding site
862965006476	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
862965006477	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
862965006478	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
862965006479	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
862965006480	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
862965006481	catalytic site [active]
862965006482	G-X2-G-X-G-K; other site