-- dump date 20140619_104831 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type NP_438174.1 16271977 950899 2..1021 1 NC_000907.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; glyceraldehyde-3-phosphate dehydrogenase 1021 gapdH 950899 gapdH Haemophilus influenzae Rd KW20 glyceraldehyde-3-phosphate dehydrogenase NP_438174.1 2 D 71421 CDS NP_438175.1 16271978 950897 1190..3013 1 NC_000907.1 similar to GB:AE000782; long chain fatty acid CoA ligase 3013 950897 HI0002 Haemophilus influenzae Rd KW20 long chain fatty acid CoA ligase NP_438175.1 1190 D 71421 CDS NP_438176.1 16271979 950898 complement(3050..3838) 1 NC_000907.1 similar to GB:L10328 SP:P09997 PID:290545 PID:41648 GB:U00096; haloacid dehalogenase-like protein 3838 950898 HI0003 Haemophilus influenzae Rd KW20 haloacid dehalogenase-like protein NP_438176.1 3050 R 71421 CDS NP_438177.1 16271980 950900 complement(3854..4318) 1 NC_000907.1 similar to GB:U00096 SP:P77385 PID:1778578 PID:1786880; metalloprotease 4318 950900 HI0004 Haemophilus influenzae Rd KW20 metalloprotease NP_438177.1 3854 R 71421 CDS NP_438178.1 16271981 950902 complement(4579..5391) 1 NC_000907.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 5391 fdhD 950902 fdhD Haemophilus influenzae Rd KW20 formate dehydrogenase accessory protein NP_438178.1 4579 R 71421 CDS NP_438180.1 16271982 950904 8750..9688 1 NC_000907.1 similar to SP:P24184 GB:U00096 PID:1742408 PID:1742418 PID:1787749; formate dehydrogenase subunit beta 9688 fdxH 950904 fdxH Haemophilus influenzae Rd KW20 formate dehydrogenase subunit beta NP_438180.1 8750 D 71421 CDS NP_438181.1 16271983 950906 9681..10397 1 NC_000907.1 similar to GB:L19201 SP:P32174 PID:304996 GB:U00096 PID:1790325; formate dehydrogenase subunit gamma 10397 fdxI 950906 fdxI Haemophilus influenzae Rd KW20 formate dehydrogenase subunit gamma NP_438181.1 9681 D 71421 CDS NP_438182.1 16271984 950905 10467..11375 1 NC_000907.1 required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 11375 fdhE 950905 fdhE Haemophilus influenzae Rd KW20 formate dehydrogenase accessory protein FdhE NP_438182.1 10467 D 71421 CDS NP_438183.1 16271985 950907 complement(11414..11854) 1 NC_000907.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 11854 rimI 950907 rimI Haemophilus influenzae Rd KW20 ribosomal-protein-alanine N-acetyltransferase NP_438183.1 11414 R 71421 CDS NP_438184.1 16271986 950908 complement(11857..12261) 1 NC_000907.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 12261 holD 950908 holD Haemophilus influenzae Rd KW20 DNA polymerase III subunit psi NP_438184.1 11857 R 71421 CDS NP_438185.1 16271987 950903 12367..13359 1 NC_000907.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase 13359 rsmC 950903 rsmC Haemophilus influenzae Rd KW20 16S ribosomal RNA m2G1207 methyltransferase NP_438185.1 12367 D 71421 CDS NP_438186.1 16271988 950911 complement(13423..14331) 1 NC_000907.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 14331 era 950911 era Haemophilus influenzae Rd KW20 GTP-binding protein Era NP_438186.1 13423 R 71421 CDS NP_438187.1 16271989 950910 complement(14328..15011) 1 NC_000907.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 15011 rnc 950910 rnc Haemophilus influenzae Rd KW20 ribonuclease III NP_438187.1 14328 R 71421 CDS NP_438188.1 16271990 950912 complement(15013..16062) 1 NC_000907.1 similar to GB:K00426 SP:P00803 PID:146600 PID:987643 GB:U00096; signal peptidase I 16062 lepB 950912 lepB Haemophilus influenzae Rd KW20 signal peptidase I NP_438188.1 15013 R 71421 CDS NP_438189.1 16271991 950909 complement(16071..17867) 1 NC_000907.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 17867 lepA 950909 lepA Haemophilus influenzae Rd KW20 GTP-binding protein LepA NP_438189.1 16071 R 71421 CDS NP_438190.1 16271992 950913 complement(18035..18418) 1 NC_000907.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA 18418 950913 HI0017 Haemophilus influenzae Rd KW20 autonomous glycyl radical cofactor GrcA NP_438190.1 18035 R 71421 CDS NP_438191.1 16271993 950914 18676..19335 1 NC_000907.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 19335 ung 950914 ung Haemophilus influenzae Rd KW20 uracil-DNA glycosylase NP_438191.1 18676 D 71421 CDS NP_438192.1 16271994 950916 complement(19405..20829) 1 NC_000907.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 20829 950916 HI0019 Haemophilus influenzae Rd KW20 (dimethylallyl)adenosine tRNA methylthiotransferase NP_438192.1 19405 R 71421 CDS NP_438193.1 16271995 950917 complement(21248..22687) 1 NC_000907.1 similar to GB:U00096 SP:P75763 PID:1786986; hypothetical protein 22687 950917 HI0020 Haemophilus influenzae Rd KW20 hypothetical protein NP_438193.1 21248 R 71421 CDS NP_438194.1 16271996 950919 complement(22689..23939) 1 NC_000907.1 similar to GB:U00096 SP:P77231 PID:1778530 PID:1786830; CitG protein 23939 citG 950919 citG Haemophilus influenzae Rd KW20 CitG protein NP_438194.1 22689 R 71421 CDS NP_438195.1 16271997 950920 complement(24267..25769) 1 NC_000907.1 similar to GB:U00096 SP:P75726 PID:1778532 PID:1786832; citrate lyase subunit alpha 25769 citF 950920 citF Haemophilus influenzae Rd KW20 citrate lyase subunit alpha NP_438195.1 24267 R 71421 CDS NP_438196.2 30995348 950915 complement(25784..26641) 1 NC_000907.1 similar to GB:U00096 SP:P77770 PID:1778533 PID:1786833; citrate lyase subunit beta 26641 citE 950915 citE Haemophilus influenzae Rd KW20 citrate lyase subunit beta NP_438196.2 25784 R 71421 CDS NP_438197.1 16271999 950921 complement(26656..26943) 1 NC_000907.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma 26943 citD 950921 citD Haemophilus influenzae Rd KW20 citrate lyase subunit gamma NP_438197.1 26656 R 71421 CDS NP_438198.1 16272000 950918 complement(26981..27988) 1 NC_000907.1 similar to SP:P77390; citrate lyase ligase 27988 citC 950918 citC Haemophilus influenzae Rd KW20 citrate lyase ligase NP_438198.1 26981 R 71421 CDS NP_438199.1 16272001 950923 complement(28239..29201) 1 NC_000907.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 29201 lipA 950923 lipA Haemophilus influenzae Rd KW20 lipoyl synthase NP_438199.1 28239 R 71421 CDS NP_438200.1 16272002 950925 complement(29255..29893) 1 NC_000907.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 29893 lipB 950925 lipB Haemophilus influenzae Rd KW20 lipoate-protein ligase B NP_438200.1 29255 R 71421 CDS NP_438201.1 16272003 950924 complement(29895..30173) 1 NC_000907.1 similar to GB:L07636 SP:P30977 PID:146621 GB:U00096 PID:1778548; hypothetical protein 30173 950924 HI0028 Haemophilus influenzae Rd KW20 hypothetical protein NP_438201.1 29895 R 71421 CDS NP_438202.1 16272004 950922 complement(30229..31410) 1 NC_000907.1 similar to SP:P04287 PID:146620 PID:147661 PID:41212 GB:U00096; penicillin-binding protein 5 31410 dacA 950922 dacA Haemophilus influenzae Rd KW20 penicillin-binding protein 5 NP_438202.1 30229 R 71421 CDS NP_438203.1 16272005 950926 complement(31426..32289) 1 NC_000907.1 similar to GB:M18276 SP:P10100 PID:147660 GB:U00096 PID:1651260; lipoprotein 32289 950926 HI0030 Haemophilus influenzae Rd KW20 lipoprotein NP_438203.1 31426 R 71421 CDS NP_438204.1 16272006 950927 complement(32341..33456) 1 NC_000907.1 similar to GB:M22857 SP:P15035 PID:147695 GB:U00096 PID:1651261; rod shape-determining protein 33456 rodA 950927 rodA Haemophilus influenzae Rd KW20 rod shape-determining protein NP_438204.1 32341 R 71421 CDS NP_438205.1 16272007 950929 complement(33446..35401) 1 NC_000907.1 similar to SP:P08150 GB:X04516 PID:147694 PID:42316 GB:U00096; penicillin-binding protein 2 35401 pbp2 950929 pbp2 Haemophilus influenzae Rd KW20 penicillin-binding protein 2 NP_438205.1 33446 R 71421 CDS NP_438206.1 16272008 950930 complement(35422..35889) 1 NC_000907.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 35889 950930 HI0033 Haemophilus influenzae Rd KW20 rRNA large subunit methyltransferase NP_438206.1 35422 R 71421 CDS NP_438207.1 16272009 950928 complement(35943..36251) 1 NC_000907.1 similar to SP:P05848 GB:X04516 PID:42314 GB:U00096 PID:1778554; hypothetical protein 36251 950928 HI0034 Haemophilus influenzae Rd KW20 hypothetical protein NP_438207.1 35943 R 71421 CDS NP_438208.1 16272010 950933 complement(36376..38031) 1 NC_000907.1 similar to GB:L10328 SP:P29211 GB:M94104 PID:290534 PID:147371; hypothetical protein 38031 950933 HI0035 Haemophilus influenzae Rd KW20 hypothetical protein NP_438208.1 36376 R 71421 CDS NP_438209.1 16272011 950931 38237..40015 1 NC_000907.1 similar to SP:Q50614 PID:1483552; ABC transporter ATP-binding protein 40015 950931 HI0036 Haemophilus influenzae Rd KW20 ABC transporter ATP-binding protein NP_438209.1 38237 D 71421 CDS NP_438210.2 30995349 950934 40145..41200 1 NC_000907.1 functions in MreBCD complex in some organisms; rod shape-determining protein MreB 41200 mreB 950934 mreB Haemophilus influenzae Rd KW20 rod shape-determining protein MreB NP_438210.2 40145 D 71421 CDS NP_438211.1 16272013 950932 41280..42335 1 NC_000907.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 42335 mreC 950932 mreC Haemophilus influenzae Rd KW20 rod shape-determining protein MreC NP_438211.1 41280 D 71421 CDS NP_438212.1 16272014 950936 42335..42823 1 NC_000907.1 similar to GB:M31792 SP:P16927 PID:146819 PID:606189 GB:U00096; rod shape-determining protein MreD 42823 mreD 950936 mreD Haemophilus influenzae Rd KW20 rod shape-determining protein MreD NP_438212.1 42335 D 71421 CDS NP_438213.1 16272015 950937 complement(42874..43650) 1 NC_000907.1 similar to PID:1944176; hypothetical protein 43650 950937 HI0040 Haemophilus influenzae Rd KW20 hypothetical protein NP_438213.1 42874 R 71421 CDS NP_438214.1 16272016 950938 complement(43660..44463) 1 NC_000907.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 44463 xthA 950938 xthA Haemophilus influenzae Rd KW20 exonuclease III NP_438214.1 43660 R 71421 CDS NP_438215.1 16272017 950939 complement(44511..45185) 1 NC_000907.1 similar to SP:P39219 GB:U00096 PID:1786244; pseudouridine synthase-like protein 45185 950939 HI0042 Haemophilus influenzae Rd KW20 pseudouridine synthase-like protein NP_438215.1 44511 R 71421 CDS NP_438216.1 16272018 950940 complement(45185..46249) 1 NC_000907.1 similar to SP:P45525 GB:U00096 PID:1787582; hypothetical protein 46249 950940 HI0043 Haemophilus influenzae Rd KW20 hypothetical protein NP_438216.1 45185 R 71421 CDS NP_438217.1 16272019 950935 complement(46309..46971) 1 NC_000907.1 similar to SP:P06967 GB:X00547 PID:41284 GB:U00096 PID:1787205; hypothetical protein 46971 950935 HI0044 Haemophilus influenzae Rd KW20 hypothetical protein NP_438217.1 46309 R 71421 CDS NP_438218.1 16272020 950943 complement(47298..47852) 1 NC_000907.1 similar to GB:U14003 SP:P39187 PID:471102 PID:537057 GB:U00096; hypothetical protein 47852 950943 HI0045 Haemophilus influenzae Rd KW20 hypothetical protein NP_438218.1 47298 R 71421 CDS NP_438219.2 30995350 950944 47955..48281 1 NC_000907.1 similar to SP:P16680 GB:U14003 PID:147194 PID:536952 GB:U00096; alkylphosphonate uptake protein 48281 phnA 950944 phnA Haemophilus influenzae Rd KW20 alkylphosphonate uptake protein NP_438219.2 47955 D 71421 CDS NP_438220.1 16272022 950945 complement(48334..48972) 1 NC_000907.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 48972 eda 950945 eda Haemophilus influenzae Rd KW20 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase NP_438220.1 48334 R 71421 CDS NP_438221.1 16272023 950942 complement(48991..49848) 1 NC_000907.1 Converts D-mannonate to D-mannuronate; D-mannonate oxidoreductase 49848 950942 HI0048 Haemophilus influenzae Rd KW20 D-mannonate oxidoreductase NP_438221.1 48991 R 71421 CDS NP_438222.1 16272024 950949 complement(49848..50792) 1 NC_000907.1 similar to GB:X75047 SP:P45416 PID:495249; 2-dehydro-3-deoxygluconokinase 50792 kdgK 950949 kdgK Haemophilus influenzae Rd KW20 2-dehydro-3-deoxygluconokinase NP_438222.1 49848 R 71421 CDS NP_438223.1 16273630 950948 complement(50812..52068) 1 NC_000907.1 integral membrane protein transporter 52068 950948 HI0050m Haemophilus influenzae Rd KW20 integral membrane protein transporter NP_438223.1 50812 R 71421 CDS NP_438224.1 16272025 950946 complement(52092..52589) 1 NC_000907.1 similar to SP:P37674 PID:466715 GB:U00096 PID:1790002; hypothetical protein 52589 950946 HI0051 Haemophilus influenzae Rd KW20 hypothetical protein NP_438224.1 52092 R 71421 CDS NP_438225.1 16272026 950947 complement(52628..53614) 1 NC_000907.1 similar to SP:P37676 PID:466717 GB:U00096 PID:1790004; hypothetical protein 53614 950947 HI0052 Haemophilus influenzae Rd KW20 hypothetical protein NP_438225.1 52628 R 71421 CDS NP_438226.1 16272027 950952 complement(53641..54669) 1 NC_000907.1 similar to GB:M96947 SP:Q06004 PID:304153 GB:AL009126; zinc-type alcohol dehydrogenase 54669 950952 HI0053 Haemophilus influenzae Rd KW20 zinc-type alcohol dehydrogenase NP_438226.1 53641 R 71421 CDS NP_438227.2 30995351 950951 54830..55579 1 NC_000907.1 similar to GB:U14003 SP:P39161 PID:537165 PID:1160324 GB:U00096; uxu operon regulator 55579 uxuR 950951 uxuR Haemophilus influenzae Rd KW20 uxu operon regulator NP_438227.2 54830 D 71421 CDS NP_438228.1 16272029 950950 55607..56791 1 NC_000907.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 56791 uxuA 950950 uxuA Haemophilus influenzae Rd KW20 mannonate dehydratase NP_438228.1 55607 D 71421 CDS NP_438229.1 16272030 950954 complement(56844..57557) 1 NC_000907.1 similar to PID:882725 GB:U00096 PID:1789197; hypothetical protein 57557 950954 HI0056 Haemophilus influenzae Rd KW20 hypothetical protein NP_438229.1 56844 R 71421 CDS NP_438230.1 16272031 950955 complement(57655..59484) 1 NC_000907.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 59484 uvrC 950955 uvrC Haemophilus influenzae Rd KW20 excinuclease ABC subunit C NP_438230.1 57655 R 71421 CDS NP_438231.1 16272032 950957 complement(59486..60250) 1 NC_000907.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 60250 kdsB 950957 kdsB Haemophilus influenzae Rd KW20 3-deoxy-manno-octulosonate cytidylyltransferase NP_438231.1 59486 R 71421 CDS NP_438232.1 16272033 950959 complement(60321..61319) 1 NC_000907.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 61319 lpxK 950959 lpxK Haemophilus influenzae Rd KW20 tetraacyldisaccharide 4'-kinase NP_438232.1 60321 R 71421 CDS NP_438233.1 16272034 950953 complement(61392..63155) 1 NC_000907.1 involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease 63155 msbA 950953 msbA Haemophilus influenzae Rd KW20 lipid transporter ATP-binding/permease NP_438233.1 61392 R 71421 CDS NP_438234.1 16272035 950960 complement(63196..65562) 1 NC_000907.1 similar to GB:L20805 PID:305386; recombination protein 65562 rec2 950960 rec2 Haemophilus influenzae Rd KW20 recombination protein NP_438234.1 63196 R 71421 CDS NP_438235.1 16272036 950956 65821..66258 1 NC_000907.1 similar to GB:D26562 SP:P18274 GB:M34945 GB:M60726 PID:145751; dnaK suppressor protein 66258 dksA 950956 dksA Haemophilus influenzae Rd KW20 dnaK suppressor protein NP_438235.1 65821 D 71421 CDS NP_438236.1 16272037 950961 66506..67864 1 NC_000907.1 similar to SP:P13685 GB:D26562 GB:M20574 GB:S48039 PID:147117; polyA polymerase 67864 pcnB 950961 pcnB Haemophilus influenzae Rd KW20 polyA polymerase NP_438236.1 66506 D 71421 CDS NP_438237.1 16272038 950962 67873..68355 1 NC_000907.1 ATP-binding protein; similar to GB:D26562 SP:P26281 GB:L06495 PID:146013 PID:473801; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 68355 folK 950962 folK Haemophilus influenzae Rd KW20 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase NP_438237.1 67873 D 71421 CDS NP_438238.1 16272039 950963 68431..68907 1 NC_000907.1 forms homotrimers; magnesium-dependent; similar to SP:P31805 PID:304913 PID:537009 GB:U00096 PID:1790610; hypothetical protein 68907 yjeE 950963 yjeE Haemophilus influenzae Rd KW20 hypothetical protein NP_438238.1 68431 D 71421 CDS NP_438239.1 16272040 950965 68915..70213 1 NC_000907.1 similar to SP:P26365 GB:Z11831 PID:304914 PID:42068 PID:537010; N-acetylmuramoyl-L-alanine amidase 70213 950965 HI0066 Haemophilus influenzae Rd KW20 N-acetylmuramoyl-L-alanine amidase NP_438239.1 68915 D 71421 CDS NP_438240.1 16272041 950964 70214..72103 1 NC_000907.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 72103 mutL 950964 mutL Haemophilus influenzae Rd KW20 DNA mismatch repair protein NP_438240.1 70214 D 71421 CDS NP_438241.1 16272042 950968 72111..73046 1 NC_000907.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 73046 miaA 950968 miaA Haemophilus influenzae Rd KW20 tRNA delta(2)-isopentenylpyrophosphate transferase NP_438241.1 72111 D 71421 CDS NP_438242.1 16272043 950967 73052..75997 1 NC_000907.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 75997 glnE 950967 glnE Haemophilus influenzae Rd KW20 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase NP_438242.1 73052 D 71421 CDS NP_438243.1 16272044 950958 complement(76082..77758) 1 NC_000907.1 similar to SP:P05824 GB:Y00357 PID:42693 PID:1033112 GB:U00096; DNA repair protein 77758 recN 950958 recN Haemophilus influenzae Rd KW20 DNA repair protein NP_438243.1 76082 R 71421 CDS NP_438244.1 16272045 950969 complement(77902..78687) 1 NC_000907.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 78687 ppnK 950969 ppnK Haemophilus influenzae Rd KW20 inorganic polyphosphate/ATP-NAD kinase NP_438244.1 77902 R 71421 CDS NP_438245.2 30995352 950971 78763..79455 1 NC_000907.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 79455 grpE 950971 grpE Haemophilus influenzae Rd KW20 heat shock protein GrpE NP_438245.2 78763 D 71421 CDS NP_438246.1 16272047 950966 complement(79468..79812) 1 NC_000907.1 forms complexes with HI0074; nucleotidyltransferase 79812 950966 HI0073 Haemophilus influenzae Rd KW20 nucleotidyltransferase NP_438246.1 79468 R 71421 CDS NP_438247.1 16272048 950972 complement(79805..80245) 1 NC_000907.1 forms homodimers and complexes with HI0073; nucleotidyltransferase 80245 950972 HI0074 Haemophilus influenzae Rd KW20 nucleotidyltransferase NP_438247.1 79805 R 71421 CDS NP_438248.1 16272049 950970 80526..82649 1 NC_000907.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 82649 nrdD 950970 nrdD Haemophilus influenzae Rd KW20 anaerobic ribonucleoside triphosphate reductase NP_438248.1 80526 D 71421 CDS NP_438249.1 16272050 950974 82767..83627 1 NC_000907.1 similar to GB:M63308 SP:P23911 PID:147932 GB:U00096 PID:1773136; acyl-CoA thioesterase II 83627 tesB 950974 tesB Haemophilus influenzae Rd KW20 acyl-CoA thioesterase II NP_438249.1 82767 D 71421 CDS NP_438250.1 16272051 950975 83638..84504 1 NC_000907.1 hypothetical protein 84504 950975 HI0077 Haemophilus influenzae Rd KW20 hypothetical protein NP_438250.1 83638 D 71421 CDS NP_438251.1 16272052 950973 complement(84580..85959) 1 NC_000907.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 85959 cysS 950973 cysS Haemophilus influenzae Rd KW20 cysteinyl-tRNA synthetase NP_438251.1 84580 R 71421 CDS NP_438252.1 16272053 950978 86062..86571 1 NC_000907.1 similar to GB:M55430 SP:P23869 GB:X59293 PID:145290 PID:41205; peptidyl-prolyl cis-trans isomerase B 86571 ppiB 950978 ppiB Haemophilus influenzae Rd KW20 peptidyl-prolyl cis-trans isomerase B NP_438252.1 86062 D 71421 CDS NP_438253.1 16272054 950976 86575..87006 1 NC_000907.1 similar to GB:U00096 PID:2367279; hypothetical protein 87006 950976 HI0080 Haemophilus influenzae Rd KW20 hypothetical protein NP_438253.1 86575 D 71421 CDS NP_438254.1 16272055 950980 87148..87936 1 NC_000907.1 similar to GB:U14003 SP:P39408 PID:537218 GB:U00096 PID:1790838; hypothetical protein 87936 950980 HI0081 Haemophilus influenzae Rd KW20 hypothetical protein NP_438254.1 87148 D 71421 CDS NP_438255.1 16272056 950979 88193..88459 1 NC_000907.1 hypothetical protein 88459 950979 HI0082 Haemophilus influenzae Rd KW20 hypothetical protein NP_438255.1 88193 D 71421 CDS NP_438257.1 16272058 950983 complement(88739..89062) 1 NC_000907.1 similar to GB:J04475 SP:P12243 PID:142154; thioredoxin 89062 trxM 950983 trxM Haemophilus influenzae Rd KW20 thioredoxin NP_438257.1 88739 R 71421 CDS NP_438258.1 16272059 950977 complement(89182..90177) 1 NC_000907.1 Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynthes; D-lactate dehydrogenase 90177 ldhA 950977 ldhA Haemophilus influenzae Rd KW20 D-lactate dehydrogenase NP_438258.1 89182 R 71421 CDS NP_438259.1 16272060 950982 complement(90190..91335) 1 NC_000907.1 catalyzes the formation of cysteine from cystathionine; in B. subtilis also has O-acetylhomoserine thiolyase activity; cystathionine gamma-synthase 91335 metB 950982 metB Haemophilus influenzae Rd KW20 cystathionine gamma-synthase NP_438259.1 90190 R 71421 CDS NP_438260.1 16272061 950990 complement(92148..93425) 1 NC_000907.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 93425 thrC 950990 thrC Haemophilus influenzae Rd KW20 threonine synthase NP_438260.1 92148 R 71421 CDS NP_438261.1 16272062 950993 complement(93468..94412) 1 NC_000907.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 94412 thrB 950993 thrB Haemophilus influenzae Rd KW20 homoserine kinase NP_438261.1 93468 R 71421 CDS NP_438262.1 16272063 950991 complement(94425..96872) 1 NC_000907.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 96872 thrA 950991 thrA Haemophilus influenzae Rd KW20 bifunctional aspartokinase I/homoserine dehydrogenase I NP_438262.1 94425 R 71421 CDS NP_438263.1 16272064 950992 97196..97909 1 NC_000907.1 similar to PID:882480 SP:P52054 GB:U00096 PID:1789321; hypothetical protein 97909 950992 HI0090 Haemophilus influenzae Rd KW20 hypothetical protein NP_438263.1 97196 D 71421 CDS NP_438264.1 16272065 950989 complement(97949..99085) 1 NC_000907.1 similar to SP:P42100 PID:563934 PID:904179 GB:AL009126; hypothetical protein 99085 950989 HI0091 Haemophilus influenzae Rd KW20 hypothetical protein NP_438264.1 97949 R 71421 CDS NP_438265.1 16272066 950987 complement(99094..100353) 1 NC_000907.1 hypothetical protein 100353 950987 HI0092 Haemophilus influenzae Rd KW20 hypothetical protein NP_438265.1 99094 R 71421 CDS NP_438266.1 16272067 950994 complement(100475..101581) 1 NC_000907.1 similar to SP:P37047 GB:U00096 PID:1552740 PID:1786357; hypothetical protein 101581 950994 HI0093 Haemophilus influenzae Rd KW20 hypothetical protein NP_438266.1 100475 R 71421 CDS NP_438268.2 30995353 950995 complement(101783..102103) 1 NC_000907.1 hypothetical protein 102103 950995 HI0094 Haemophilus influenzae Rd KW20 hypothetical protein NP_438268.2 101783 R 71421 CDS NP_438269.1 16272069 950997 complement(102453..103208) 1 NC_000907.1 similar to PID:2104289; hypothetical protein 103208 950997 HI0095 Haemophilus influenzae Rd KW20 hypothetical protein NP_438269.1 102453 R 71421 CDS NP_438270.1 16272070 951000 103542..104117 1 NC_000907.1 hypothetical protein 104117 951000 HI0096 Haemophilus influenzae Rd KW20 hypothetical protein NP_438270.1 103542 D 71421 CDS NP_438271.2 30995354 950998 join(104277..104318,104318..105274) 1 NC_000907.1 periplasmic ferric iron binding protein; contains a frameshift with respect to purified protein; similar to PID:2340838; iron-utilization periplasmic protein hFbpA 105274 hitA 950998 hitA Haemophilus influenzae Rd KW20 iron-utilization periplasmic protein hFbpA NP_438271.2 104277 D 71421 CDS NP_438272.2 30995355 951001 105476..106912 1 NC_000907.1 similar to GB:M33815 SP:P21409 PID:152861; iron(III) ABC transporter permease 106912 hitB 951001 hitB Haemophilus influenzae Rd KW20 iron(III) ABC transporter permease NP_438272.2 105476 D 71421 CDS NP_438273.1 16272073 951003 106914..107969 1 NC_000907.1 similar to PID:1098689; iron(III) ABC transporter ATP-binding protein 107969 hitC 951003 hitC Haemophilus influenzae Rd KW20 iron(III) ABC transporter ATP-binding protein NP_438273.1 106914 D 71421 CDS NP_438276.1 16272076 950999 complement(108685..109818) 1 NC_000907.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 109818 dapE 950999 dapE Haemophilus influenzae Rd KW20 succinyl-diaminopimelate desuccinylase NP_438276.1 108685 R 71421 CDS NP_438277.1 16272077 951002 complement(109846..110190) 1 NC_000907.1 similar to SP:P24178 GB:X57403 PID:41233 GB:U00096 PID:1788815; hypothetical protein 110190 951002 HI0103 Haemophilus influenzae Rd KW20 hypothetical protein NP_438277.1 109846 R 71421 CDS NP_438278.1 16272078 951006 complement(110269..112164) 1 NC_000907.1 molecular chaperone; heat shock protein 90 112164 htpG 951006 htpG Haemophilus influenzae Rd KW20 heat shock protein 90 NP_438278.1 110269 R 71421 CDS NP_438279.2 30995356 951007 112465..113220 1 NC_000907.1 similar to GB:U00096 SP:P75743 PID:1786928; hypothetical protein 113220 951007 HI0105 Haemophilus influenzae Rd KW20 hypothetical protein NP_438279.2 112465 D 71421 CDS NP_438280.1 16272080 951009 complement(113277..114665) 1 NC_000907.1 similar to SP:P07019 PID:43142 GB:U00096 PID:1788963; Signal recognition particle protein 114665 ffh 951009 ffh Haemophilus influenzae Rd KW20 Signal recognition particle protein NP_438280.1 113277 R 71421 CDS NP_438281.1 16272081 951005 114997..116208 1 NC_000907.1 similar to GB:U00096 PID:1788966; Mg2+/Co2+ transporter 116208 951005 HI0107 Haemophilus influenzae Rd KW20 Mg2+/Co2+ transporter NP_438281.1 114997 D 71421 CDS NP_438282.1 16272082 951010 116337..117230 1 NC_000907.1 similar to GB:U14003 SP:P39402 PID:537207 GB:U00096 PID:1790826; hypothetical protein 117230 951010 HI0108 Haemophilus influenzae Rd KW20 hypothetical protein NP_438282.1 116337 D 71421 CDS NP_438283.1 16272083 951013 complement(117319..117660) 1 NC_000907.1 hypothetical protein 117660 951013 HI0109 Haemophilus influenzae Rd KW20 hypothetical protein NP_438283.1 117319 R 71421 CDS NP_438284.1 16272084 951014 117827..119116 1 NC_000907.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 119116 serS 951014 serS Haemophilus influenzae Rd KW20 seryl-tRNA synthetase NP_438284.1 117827 D 71421 CDS NP_438285.1 16272085 951011 119451..120080 1 NC_000907.1 similar to GB:X76500 PID:520921; glutathione transferase 120080 bphH 951011 bphH Haemophilus influenzae Rd KW20 glutathione transferase NP_438285.1 119451 D 71421 CDS NP_438286.1 16272086 951016 complement(120092..120388) 1 NC_000907.1 hypothetical protein 120388 951016 HI0112 Haemophilus influenzae Rd KW20 hypothetical protein NP_438286.1 120092 R 71421 CDS NP_438287.1 16272087 951015 120441..122675 1 NC_000907.1 similar to SP:Q56989 PID:1407797; hemin receptor 122675 hemR 951015 hemR Haemophilus influenzae Rd KW20 hemin receptor NP_438287.1 120441 D 71421 CDS NP_438289.1 16273671 951025 132027..132959 1 NC_000907.1 murein transglycosylase A 132959 mltA 951025 mltA Haemophilus influenzae Rd KW20 murein transglycosylase A NP_438289.1 132027 D 71421 CDS NP_438290.1 16272088 951021 132944..133729 1 NC_000907.1 similar to GB:D21145 PID:471103 PID:882707 GB:U00096 SP:Q46927; hypothetical protein 133729 951021 HI0118 Haemophilus influenzae Rd KW20 hypothetical protein NP_438290.1 132944 D 71421 CDS NP_438291.1 16272089 951027 133907..134920 1 NC_000907.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter substrate-binding protein 134920 znuA 951027 znuA Haemophilus influenzae Rd KW20 high-affinity zinc transporter substrate-binding protein NP_438291.1 133907 D 71421 CDS NP_438292.1 16272090 951028 complement(134970..135476) 1 NC_000907.1 hypothetical protein 135476 951028 HI0120 Haemophilus influenzae Rd KW20 hypothetical protein NP_438292.1 134970 R 71421 CDS NP_438293.1 16272091 951026 complement(135589..136950) 1 NC_000907.1 similar to GB:U14003 SP:P37773 PID:537075 GB:U00096 PID:1790680; UDP-N-acetylmuramoylalanine-D-glutamate ligase-like protein 136950 951026 HI0121 Haemophilus influenzae Rd KW20 UDP-N-acetylmuramoylalanine-D-glutamate ligase-like protein NP_438293.1 135589 R 71421 CDS NP_438294.1 16272092 951030 complement(137335..138525) 1 NC_000907.1 catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 138525 metC 951030 metC Haemophilus influenzae Rd KW20 cystathionine beta-lyase NP_438294.1 137335 R 71421 CDS NP_438295.1 16272093 951031 138800..139357 1 NC_000907.1 similar to GB:M12299 SP:P06978 PID:473749 GB:U00096 PID:1736571; phosphatidylglycerophosphate synthase 139357 pgsA 951031 pgsA Haemophilus influenzae Rd KW20 phosphatidylglycerophosphate synthase NP_438295.1 138800 D 71421 CDS NP_438296.1 16272094 951032 complement(139924..140454) 1 NC_000907.1 catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 140454 ppa 951032 ppa Haemophilus influenzae Rd KW20 inorganic pyrophosphatase NP_438296.1 139924 R 71421 CDS NP_438297.1 16272095 951038 140689..142005 1 NC_000907.1 similar to SP:P32702 PID:396399 GB:U00096 PID:1790499; hypothetical protein 142005 951038 HI0125 Haemophilus influenzae Rd KW20 hypothetical protein NP_438297.1 140689 D 71421 CDS NP_438298.1 16272096 951036 complement(142163..143149) 1 NC_000907.1 Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import; ferric transporter ATP-binding protein 143149 fbpC 951036 fbpC Haemophilus influenzae Rd KW20 ferric transporter ATP-binding protein NP_438298.1 142163 R 71421 CDS NP_438299.1 16272097 951037 complement(143193..145091) 1 NC_000907.1 ferric transport system permease-like protein 145091 afuB 951037 afuB Haemophilus influenzae Rd KW20 ferric transport system permease-like protein NP_438299.1 143193 R 71421 CDS NP_438300.1 16272098 951040 complement(145395..146435) 1 NC_000907.1 AfuA; similar to PID:1469286 PID:1477455; ferric ABC transporter protein 146435 afuA 951040 afuA Haemophilus influenzae Rd KW20 ferric ABC transporter protein NP_438300.1 145395 R 71421 CDS NP_438301.1 16272099 951039 146601..147242 1 NC_000907.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 147242 udk 951039 udk Haemophilus influenzae Rd KW20 uridine kinase NP_438301.1 146601 D 71421 CDS NP_438302.1 16272100 951042 147251..147838 1 NC_000907.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 147838 dcd 951042 dcd Haemophilus influenzae Rd KW20 deoxycytidine triphosphate deaminase NP_438302.1 147251 D 71421 CDS NP_438303.1 16272101 951034 147842..149017 1 NC_000907.1 hypothetical protein 149017 951034 HI0134 Haemophilus influenzae Rd KW20 hypothetical protein NP_438303.1 147842 D 71421 CDS NP_438304.1 16272102 951043 149017..150207 1 NC_000907.1 similar to GB:AE000511 PID:2314345; sugar efflux transporter 150207 951043 HI0135 Haemophilus influenzae Rd KW20 sugar efflux transporter NP_438304.1 149017 D 71421 CDS NP_438305.1 16272103 951041 complement(150287..151801) 1 NC_000907.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 151801 engA 951041 engA Haemophilus influenzae Rd KW20 GTP-binding protein EngA NP_438305.1 150287 R 71421 CDS NP_438306.1 16272104 951047 complement(152492..153262) 1 NC_000907.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 153262 dnaQ 951047 dnaQ Haemophilus influenzae Rd KW20 DNA polymerase III subunit epsilon NP_438306.1 152492 R 71421 CDS NP_438307.1 16272105 951050 153323..153787 1 NC_000907.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 153787 rnhA 951050 rnhA Haemophilus influenzae Rd KW20 ribonuclease H NP_438307.1 153323 D 71421 CDS NP_438308.1 16272106 951048 154039..155118 1 NC_000907.1 similar to GB:J03359 SP:P20149; outer membrane protein P2 155118 ompP2 951048 ompP2 Haemophilus influenzae Rd KW20 outer membrane protein P2 NP_438308.1 154039 D 71421 CDS NP_438309.1 16272107 951049 complement(155307..156452) 1 NC_000907.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 156452 nagA 951049 nagA Haemophilus influenzae Rd KW20 N-acetylglucosamine-6-phosphate deacetylase NP_438309.1 155307 R 71421 CDS NP_438310.1 16272108 951053 complement(156725..157537) 1 NC_000907.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 157537 nagB 951053 nagB Haemophilus influenzae Rd KW20 glucosamine-6-phosphate deaminase NP_438310.1 156725 R 71421 CDS NP_438311.1 16272109 951045 complement(157823..158704) 1 NC_000907.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 158704 nanA 951045 nanA Haemophilus influenzae Rd KW20 N-acetylneuraminate lyase NP_438311.1 157823 R 71421 CDS NP_438312.1 16272110 951052 complement(158715..159581) 1 NC_000907.1 similar to GB:M81878 SP:P26833 PID:144859; hypothetical protein 159581 951052 HI0143 Haemophilus influenzae Rd KW20 hypothetical protein NP_438312.1 158715 R 71421 CDS NP_438313.1 16272111 951055 complement(159574..160476) 1 NC_000907.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 160476 951055 HI0144 Haemophilus influenzae Rd KW20 N-acetylmannosamine kinase NP_438313.1 159574 R 71421 CDS NP_438314.1 16272112 951054 complement(160522..161208) 1 NC_000907.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 161208 951054 HI0145 Haemophilus influenzae Rd KW20 N-acetylmannosamine-6-phosphate 2-epimerase NP_438314.1 160522 R 71421 CDS NP_438315.1 16272113 951056 161558..162547 1 NC_000907.1 similar to SP:P37676 PID:466717 GB:U00096 PID:1790004; hypothetical protein 162547 951056 HI0146 Haemophilus influenzae Rd KW20 hypothetical protein NP_438315.1 161558 D 71421 CDS NP_438316.1 16272114 951057 162558..164459 1 NC_000907.1 similar to SP:P37675 PID:466716 GB:U00096 PID:1790003; hypothetical protein 164459 951057 HI0147 Haemophilus influenzae Rd KW20 hypothetical protein NP_438316.1 162558 D 71421 CDS NP_438317.1 16272115 951058 164623..165762 1 NC_000907.1 similar to GB:U14003 SP:P39371 PID:537151 GB:U00096 PID:1790764; N-acetylneuraminic acid mutarotase 165762 951058 HI0148 Haemophilus influenzae Rd KW20 N-acetylneuraminic acid mutarotase NP_438317.1 164623 D 71421 CDS NP_438320.1 16272118 951060 complement(166400..167287) 1 NC_000907.1 similar to SP:P25661 GB:U00005 PID:436158 PID:537016 GB:U00096; hypothetical protein 167287 hflC 951060 hflC Haemophilus influenzae Rd KW20 hypothetical protein NP_438320.1 166400 R 71421 CDS NP_438321.1 16272119 951061 complement(167287..168519) 1 NC_000907.1 similar to SP:P25662 GB:U00005 PID:436157 PID:537015 GB:U00096; HflK protein 168519 hflK 951061 hflK Haemophilus influenzae Rd KW20 HflK protein NP_438321.1 167287 R 71421 CDS NP_438322.1 16272120 951063 complement(168629..169336) 1 NC_000907.1 hypothetical protein 169336 951063 HI0152 Haemophilus influenzae Rd KW20 hypothetical protein NP_438322.1 168629 R 71421 CDS NP_438324.1 16272121 951065 complement(170930..171160) 1 NC_000907.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 171160 acpP 951065 acpP Haemophilus influenzae Rd KW20 acyl carrier protein NP_438324.1 170930 R 71421 CDS NP_438325.1 16272122 951066 complement(171416..172144) 1 NC_000907.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 172144 fabG 951066 fabG Haemophilus influenzae Rd KW20 3-ketoacyl-ACP reductase NP_438325.1 171416 R 71421 CDS NP_438326.1 16272123 951062 complement(172161..173099) 1 NC_000907.1 similar to GB:M87040 SP:P25715 GB:Z11565 PID:145887 PID:41364; acyl carrier protein S-malonyltransferase 173099 fabD 951062 fabD Haemophilus influenzae Rd KW20 acyl carrier protein S-malonyltransferase NP_438326.1 172161 R 71421 CDS NP_438327.1 16272124 951067 complement(173727..174677) 1 NC_000907.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 174677 fabH 951067 fabH Haemophilus influenzae Rd KW20 3-oxoacyl-ACP synthase NP_438327.1 173727 R 71421 CDS NP_438328.1 16272125 951068 complement(174863..175033) 1 NC_000907.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 175033 rpmF 951068 rpmF Haemophilus influenzae Rd KW20 50S ribosomal protein L32 NP_438328.1 174863 R 71421 CDS NP_438329.1 16272126 951069 complement(175056..175580) 1 NC_000907.1 similar to GB:M29698 SP:P14189 PID:146052 PID:147711 GB:U00096; hypothetical protein 175580 951069 HI0159 Haemophilus influenzae Rd KW20 hypothetical protein NP_438329.1 175056 R 71421 CDS NP_438330.1 16272127 951070 175737..176609 1 NC_000907.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 176609 psd 951070 psd Haemophilus influenzae Rd KW20 phosphatidylserine decarboxylase NP_438330.1 175737 D 71421 CDS NP_438331.1 16272128 951071 complement(176718..178088) 1 NC_000907.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 178088 gor 951071 gor Haemophilus influenzae Rd KW20 glutathione reductase NP_438331.1 176718 R 71421 CDS NP_438332.1 16272129 951072 complement(178304..178903) 1 NC_000907.1 similar to GB:U00096 PID:1773118 PID:1786637; lipoprotein 178903 951072 HI0162 Haemophilus influenzae Rd KW20 lipoprotein NP_438332.1 178304 R 71421 CDS NP_438333.1 16272130 951075 178997..179308 1 NC_000907.1 similar to PID:663269; transcriptional regulator 179308 bolA 951075 bolA Haemophilus influenzae Rd KW20 transcriptional regulator NP_438333.1 178997 D 71421 CDS NP_438334.1 16272131 951076 179599..180942 1 NC_000907.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit A 180942 951076 HI0164 Haemophilus influenzae Rd KW20 Na(+)-translocating NADH-quinone reductase subunit A NP_438334.1 179599 D 71421 CDS NP_438335.1 16272132 951078 180945..182180 1 NC_000907.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit B 182180 nqrB 951078 nqrB Haemophilus influenzae Rd KW20 Na(+)-translocating NADH-quinone reductase subunit B NP_438335.1 180945 D 71421 CDS NP_438336.1 16272133 951074 182173..182907 1 NC_000907.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit C 182907 951074 HI0167 Haemophilus influenzae Rd KW20 Na(+)-translocating NADH-quinone reductase subunit C NP_438336.1 182173 D 71421 CDS NP_438337.1 16272134 951073 182907..183533 1 NC_000907.1 Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit D 183533 951073 HI0168 Haemophilus influenzae Rd KW20 Na(+)-translocating NADH-quinone reductase subunit D NP_438337.1 182907 D 71421 CDS NP_438338.1 16272135 951077 183537..184133 1 NC_000907.1 Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.; Na(+)-translocating NADH-quinone reductase subunit E 184133 951077 HI0170 Haemophilus influenzae Rd KW20 Na(+)-translocating NADH-quinone reductase subunit E NP_438338.1 183537 D 71421 CDS NP_438339.1 16272136 951079 184146..185381 1 NC_000907.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit F 185381 nqr6 951079 nqr6 Haemophilus influenzae Rd KW20 Na(+)-translocating NADH-quinone reductase subunit F NP_438339.1 184146 D 71421 CDS NP_438340.1 16272137 951081 185525..186565 1 NC_000907.1 similar to SP:P33944 PID:405940 GB:U00096 PID:1788543; lipoprotein 186565 951081 HI0172 Haemophilus influenzae Rd KW20 lipoprotein NP_438340.1 185525 D 71421 CDS NP_438341.1 16272138 951082 186568..186828 1 NC_000907.1 hypothetical protein 186828 951082 HI0173 Haemophilus influenzae Rd KW20 hypothetical protein NP_438341.1 186568 D 71421 CDS NP_438342.1 16272139 951080 186840..188096 1 NC_000907.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 188096 mnmA 951080 mnmA Haemophilus influenzae Rd KW20 tRNA-specific 2-thiouridylase MnmA NP_438342.1 186840 D 71421 CDS NP_438343.1 16272140 951085 complement(188140..188874) 1 NC_000907.1 similar to SP:P33644 GB:M29364 PID:1236632 PID:147364 GB:U00096; hypothetical protein 188874 951085 HI0175 Haemophilus influenzae Rd KW20 hypothetical protein NP_438343.1 188140 R 71421 CDS NP_438344.1 16272141 951084 complement(188876..189850) 1 NC_000907.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D 189850 rluD 951084 rluD Haemophilus influenzae Rd KW20 23S rRNA pseudouridine synthase D NP_438344.1 188876 R 71421 CDS NP_438345.1 16272142 951089 189958..190746 1 NC_000907.1 similar to PID:1107833; hypothetical protein 190746 951089 HI0177 Haemophilus influenzae Rd KW20 hypothetical protein NP_438345.1 189958 D 71421 CDS NP_438346.1 16272143 951088 complement(190826..191308) 1 NC_000907.1 hypothetical protein 191308 951088 HI0178 Haemophilus influenzae Rd KW20 hypothetical protein NP_438346.1 190826 R 71421 CDS NP_438347.1 16272144 951086 complement(191340..192080) 1 NC_000907.1 activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 192080 pflA 951086 pflA Haemophilus influenzae Rd KW20 pyruvate formate lyase-activating enzyme 1 NP_438347.1 191340 R 71421 CDS NP_438348.1 16272145 951083 complement(192211..194529) 1 NC_000907.1 similar to GB:X08035 SP:P09373 PID:42370 GB:U00096 PID:1651427; formate acetyltransferase 194529 951083 HI0180 Haemophilus influenzae Rd KW20 formate acetyltransferase NP_438348.1 192211 R 71421 CDS NP_438349.1 16272146 951090 complement(194557..195411) 1 NC_000907.1 similar to SP:P21501 PID:147154 GB:U00096 PID:1651428 PID:1651435; formate transporter 195411 951090 HI0181 Haemophilus influenzae Rd KW20 formate transporter NP_438349.1 194557 R 71421 CDS NP_438350.2 30995357 951092 195915..196829 1 NC_000907.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 196829 951092 HI0182 Haemophilus influenzae Rd KW20 N-acetyl-D-glucosamine kinase NP_438350.2 195915 D 71421 CDS NP_438351.1 16272148 951094 197006..198451 1 NC_000907.1 similar to PID:757741 SP:Q45068 PID:1405464 GB:AL009126; amino acid carrier protein 198451 951094 HI0183 Haemophilus influenzae Rd KW20 amino acid carrier protein NP_438351.1 197006 D 71421 CDS NP_438352.1 16272149 951093 complement(198638..199465) 1 NC_000907.1 similar to SP:P10768; esterase 199465 951093 HI0184 Haemophilus influenzae Rd KW20 esterase NP_438352.1 198638 R 71421 CDS NP_438353.1 16272150 951091 complement(199474..200610) 1 NC_000907.1 similar to SP:P25437 PID:887431 GB:U00096 PID:1786552 PID:2443392; alcohol dehydrogenase class III 200610 adhC 951091 adhC Haemophilus influenzae Rd KW20 alcohol dehydrogenase class III NP_438353.1 199474 R 71421 CDS NP_438354.1 16272151 951087 200733..201140 1 NC_000907.1 similar to GB:D26185 SP:P37510 PID:467364 GB:AL009126; HTH-type transcriptional regulator 201140 951087 HI0186 Haemophilus influenzae Rd KW20 HTH-type transcriptional regulator NP_438354.1 200733 D 71421 CDS NP_438355.1 16273687 951097 201358..201627 1 NC_000907.1 Sec-independent protein secretion pathway component TatA 201627 tatA 951097 tatA Haemophilus influenzae Rd KW20 Sec-independent protein secretion pathway component TatA NP_438355.1 201358 D 71421 CDS NP_438356.1 16273632 951096 201591..202151 1 NC_000907.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 202151 tatB 951096 tatB Haemophilus influenzae Rd KW20 sec-independent translocase NP_438356.1 201591 D 71421 CDS NP_438357.1 16272152 951098 202161..202931 1 NC_000907.1 similar to SP:P27857 GB:M87049 PID:148238 PID:148237 GB:U00096; Sec-independent protein translocase protein TatC 202931 951098 HI0188 Haemophilus influenzae Rd KW20 Sec-independent protein translocase protein TatC NP_438357.1 202161 D 71421 CDS NP_438358.1 16272153 951095 203291..204640 1 NC_000907.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 204640 gdhA 951095 gdhA Haemophilus influenzae Rd KW20 glutamate dehydrogenase NP_438358.1 203291 D 71421 CDS NP_438359.1 16272154 951099 complement(204748..205188) 1 NC_000907.1 similar to PID:1568605; ferric uptake regulation protein 205188 fur 951099 fur Haemophilus influenzae Rd KW20 ferric uptake regulation protein NP_438359.1 204748 R 71421 CDS NP_438360.1 16272155 951101 complement(205217..205741) 1 NC_000907.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA 205741 fldA 951101 fldA Haemophilus influenzae Rd KW20 flavodoxin FldA NP_438360.1 205217 R 71421 CDS NP_438361.2 30995358 951100 complement(205838..206620) 1 NC_000907.1 similar to GB:U00096 PID:1786902; esterase/lipase 206620 951100 HI0193 Haemophilus influenzae Rd KW20 esterase/lipase NP_438361.2 205838 R 71421 CDS NP_438362.1 16272157 951105 206691..207284 1 NC_000907.1 negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 207284 seqA 951105 seqA Haemophilus influenzae Rd KW20 replication initiation regulator SeqA NP_438362.1 206691 D 71421 CDS NP_438363.1 16272158 951106 207287..208645 1 NC_000907.1 similar to GB:L35031 SP:P37353 PID:520813 GB:U00096 PID:1788595; O-succinylbenzoic acid--CoA ligase 208645 menE 951106 menE Haemophilus influenzae Rd KW20 O-succinylbenzoic acid--CoA ligase NP_438363.1 207287 D 71421 CDS NP_438364.1 16272159 951104 208672..212007 1 NC_000907.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 212007 951104 HI0195.1 Haemophilus influenzae Rd KW20 potassium efflux protein KefA NP_438364.1 208672 D 71421 CDS NP_438365.1 16272160 951107 212017..213090 1 NC_000907.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 213090 aroC 951107 aroC Haemophilus influenzae Rd KW20 chorismate synthase NP_438365.1 212017 D 71421 CDS NP_438366.1 16272161 951103 213175..214035 1 NC_000907.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 214035 mepA 951103 mepA Haemophilus influenzae Rd KW20 penicillin-insensitive murein endopeptidase NP_438366.1 213175 D 71421 CDS NP_438367.1 16272162 951110 214053..214820 1 NC_000907.1 similar to SP:P14008 PID:41996 GB:U00096 PID:1788667; hypothetical protein 214820 951110 HI0198 Haemophilus influenzae Rd KW20 hypothetical protein NP_438367.1 214053 D 71421 CDS NP_438368.1 16272163 951108 214867..215823 1 NC_000907.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 215823 msbB 951108 msbB Haemophilus influenzae Rd KW20 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase NP_438368.1 214867 D 71421 CDS NP_438369.1 16273684 951109 215881..216921 1 NC_000907.1 catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 216921 selD 951109 selD Haemophilus influenzae Rd KW20 selenophosphate synthetase NP_438369.1 215881 D 71421 CDS NP_438370.2 18677785 951102 complement(217030..217380) 1 NC_000907.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 217380 rplS 951102 rplS Haemophilus influenzae Rd KW20 50S ribosomal protein L19 NP_438370.2 217030 R 71421 CDS NP_438371.1 16272165 951111 complement(217417..218157) 1 NC_000907.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 218157 trmD 951111 trmD Haemophilus influenzae Rd KW20 tRNA (guanine-N(1)-)-methyltransferase NP_438371.1 217417 R 71421 CDS NP_438372.2 30995359 951115 complement(218195..218722) 1 NC_000907.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 218722 rimM 951115 rimM Haemophilus influenzae Rd KW20 16S rRNA-processing protein RimM NP_438372.2 218195 R 71421 CDS NP_438373.1 16272167 951113 complement(218767..219015) 1 NC_000907.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 219015 rpsP 951113 rpsP Haemophilus influenzae Rd KW20 30S ribosomal protein S16 NP_438373.1 218767 R 71421 CDS NP_438374.1 16272168 951114 219308..220081 1 NC_000907.1 hypothetical protein 220081 951114 HI0205 Haemophilus influenzae Rd KW20 hypothetical protein NP_438374.1 219308 D 71421 CDS NP_438375.1 16272169 951116 220104..221915 1 NC_000907.1 similar to SP:P29240 PID:62772; NAD nucleotidase 221915 951116 HI0206 Haemophilus influenzae Rd KW20 NAD nucleotidase NP_438375.1 220104 D 71421 CDS NP_438376.1 16272170 951112 222200..222742 1 NC_000907.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 222742 aroK 951112 aroK Haemophilus influenzae Rd KW20 shikimate kinase NP_438376.1 222200 D 71421 CDS NP_438377.1 16272171 951118 222762..223850 1 NC_000907.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 223850 aroB 951118 aroB Haemophilus influenzae Rd KW20 3-dehydroquinate synthase NP_438377.1 222762 D 71421 CDS NP_438378.1 16272172 951117 223852..224712 1 NC_000907.1 similar to GB:J01600 SP:P00475 GB:V00272 GB:Z19601 PID:145706; DNA adenine methylase 224712 dam 951117 dam Haemophilus influenzae Rd KW20 DNA adenine methylase NP_438378.1 223852 D 71421 CDS NP_438379.1 16272173 951120 complement(225814..226539) 1 NC_000907.1 similar to GB:M23628 SP:P18201 PID:450384 GB:U00096 PID:1742092; phosphatidylglycerophosphatase B 226539 pgpB 951120 pgpB Haemophilus influenzae Rd KW20 phosphatidylglycerophosphatase B NP_438379.1 225814 R 71421 CDS NP_438380.2 30995360 951119 226608..227258 1 NC_000907.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 227258 ribA 951119 ribA Haemophilus influenzae Rd KW20 GTP cyclohydrolase II NP_438380.2 226608 D 71421 CDS NP_438381.1 16272175 951122 complement(227577..229121) 1 NC_000907.1 similar to SP:P06202 GB:X05491 GB:X52093 PID:47802 PID:47808; oligopeptide transporter substrate-binding protein 229121 951122 HI0213 Haemophilus influenzae Rd KW20 oligopeptide transporter substrate-binding protein NP_438381.1 227577 R 71421 CDS NP_438383.2 30995361 951121 229603..231642 1 NC_000907.1 similar to SP:P27298 GB:M93984 PID:451277 PID:466635 GB:U00096; oligopeptidase A 231642 prlC 951121 prlC Haemophilus influenzae Rd KW20 oligopeptidase A NP_438383.2 229603 D 71421 CDS NP_438384.1 16272178 951125 233477..234634 1 NC_000907.1 similar to GB:X73984 PID:393411; type I restriction/modification specificity protein 234634 hsdS 951125 hsdS Haemophilus influenzae Rd KW20 type I restriction/modification specificity protein NP_438384.1 233477 D 71421 CDS NP_438385.1 16272179 951128 234763..235293 1 NC_000907.1 similar to PID:984584 GB:U00096 SP:Q47152 PID:1552796 PID:1786422; hypothetical protein 235293 951128 HI0217 Haemophilus influenzae Rd KW20 hypothetical protein NP_438385.1 234763 D 71421 CDS NP_438387.2 30995362 951126 complement(238674..239303) 1 NC_000907.1 similar to GB:S68137 SP:P46928 PID:469476; hypothetical protein 239303 951126 HI0219 Haemophilus influenzae Rd KW20 hypothetical protein NP_438387.2 238674 R 71421 CDS NP_438388.1 16273674 951131 complement(239516..240229) 1 NC_000907.1 two component signal transduction system protein 240229 951131 HI0219a Haemophilus influenzae Rd KW20 two component signal transduction system protein NP_438388.1 239516 R 71421 CDS NP_438390.2 30995363 951123 complement(241428..242015) 1 NC_000907.1 hypothetical protein 242015 951123 HI0220.2 Haemophilus influenzae Rd KW20 hypothetical protein NP_438390.2 241428 R 71421 CDS NP_438391.1 16272182 951136 complement(247910..248818) 1 NC_000907.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 248818 birA 951136 birA Haemophilus influenzae Rd KW20 biotin--protein ligase NP_438391.1 247910 R 71421 CDS NP_438392.1 16272183 951137 248948..250414 1 NC_000907.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 250414 guaB 951137 guaB Haemophilus influenzae Rd KW20 inosine 5'-monophosphate dehydrogenase NP_438392.1 248948 D 71421 CDS NP_438393.1 16272184 951134 250524..251015 1 NC_000907.1 similar to C-terminus of HI0221; inosine-5'-monophosphate dehydrogenase-like protein 251015 951134 HI0221.1 Haemophilus influenzae Rd KW20 inosine-5'-monophosphate dehydrogenase-like protein NP_438393.1 250524 D 71421 CDS NP_438394.1 16272185 951140 251125..252696 1 NC_000907.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 252696 guaA 951140 guaA Haemophilus influenzae Rd KW20 GMP synthase NP_438394.1 251125 D 71421 CDS NP_438395.1 16272186 951139 complement(252758..253660) 1 NC_000907.1 similar to SP:P27844; hypothetical protein 253660 951139 HI0223 Haemophilus influenzae Rd KW20 hypothetical protein NP_438395.1 252758 R 71421 CDS NP_438396.2 30995364 951138 253772..254233 1 NC_000907.1 similar to SP:P55658 PID:2182633; transcriptional regulator 254233 951138 HI0224 Haemophilus influenzae Rd KW20 transcriptional regulator NP_438396.2 253772 D 71421 CDS NP_438397.1 16272188 951141 complement(254272..255474) 1 NC_000907.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 255474 nhaA 951141 nhaA Haemophilus influenzae Rd KW20 pH-dependent sodium/proton antiporter NP_438397.1 254272 R 71421 CDS NP_438398.1 16272189 951144 255662..256972 1 NC_000907.1 similar to SP:P37011 GB:U00096 PID:1657597 PID:1773085 PID:1786601; branched-chain amino acid ABC transporter 256972 brnQ 951144 brnQ Haemophilus influenzae Rd KW20 branched-chain amino acid ABC transporter NP_438398.1 255662 D 71421 CDS NP_438399.1 16272190 951142 complement(257080..257547) 1 NC_000907.1 similar to SP:P37673 PID:466714 GB:U00096 PID:1790001; hypothetical protein 257547 951142 HI0227 Haemophilus influenzae Rd KW20 hypothetical protein NP_438399.1 257080 R 71421 CDS NP_438401.1 16272192 951143 258296..260425 1 NC_000907.1 similar to GB:J02638 SP:P05055 GB:M14425 GB:X00761 PID:147749; polynucleotide phosphorylase/polyadenylase 260425 pnp 951143 pnp Haemophilus influenzae Rd KW20 polynucleotide phosphorylase/polyadenylase NP_438401.1 258296 D 71421 CDS NP_438402.1 16272193 951148 260507..261451 1 NC_000907.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI 261451 951148 HI0230 Haemophilus influenzae Rd KW20 lipoprotein NlpI NP_438402.1 260507 D 71421 CDS NP_438403.1 16272194 951147 261572..263413 1 NC_000907.1 similar to SP:P23304 GB:M63288 GB:U03750 PID:432406 PID:606102; ATP-dependent RNA helicase 263413 deaD 951147 deaD Haemophilus influenzae Rd KW20 ATP-dependent RNA helicase NP_438403.1 261572 D 71421 CDS NP_438404.1 16272195 951149 263591..264979 1 NC_000907.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; transglycosylase 264979 951149 HI0232 Haemophilus influenzae Rd KW20 transglycosylase NP_438404.1 263591 D 71421 CDS NP_438406.1 16272197 951152 complement(265624..265833) 1 NC_000907.1 similar to GB:L29458 SP:P36675 PID:473421; hypothetical protein 265833 951152 HI0235 Haemophilus influenzae Rd KW20 hypothetical protein NP_438406.1 265624 R 71421 CDS NP_438407.1 16272198 951153 complement(265901..266251) 1 NC_000907.1 similar to PID:1805555; arsenate reductase 266251 951153 HI0236 Haemophilus influenzae Rd KW20 arsenate reductase NP_438407.1 265901 R 71421 CDS NP_438409.1 16272199 951151 complement(267493..268470) 1 NC_000907.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 268470 secF 951151 secF Haemophilus influenzae Rd KW20 preprotein translocase subunit SecF NP_438409.1 267493 R 71421 CDS NP_438410.1 16272200 951150 complement(268478..270328) 1 NC_000907.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 270328 secD 951150 secD Haemophilus influenzae Rd KW20 preprotein translocase subunit SecD NP_438410.1 268478 R 71421 CDS NP_438411.1 16272201 949367 complement(270398..270691) 1 NC_000907.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 270691 yajC 949367 yajC Haemophilus influenzae Rd KW20 preprotein translocase subunit YajC NP_438411.1 270398 R 71421 CDS NP_438412.1 16272202 949384 complement(270799..271020) 1 NC_000907.1 similar to GB:L77117 SP:Q58397 PID:1591652; hypothetical protein 271020 949384 HI0242 Haemophilus influenzae Rd KW20 hypothetical protein NP_438412.1 270799 R 71421 CDS NP_438413.1 16272203 949380 complement(271017..271535) 1 NC_000907.1 hypothetical protein 271535 949380 HI0243 Haemophilus influenzae Rd KW20 hypothetical protein NP_438413.1 271017 R 71421 CDS NP_438414.1 16272204 949369 complement(271600..272748) 1 NC_000907.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 272748 tgt 949369 tgt Haemophilus influenzae Rd KW20 queuine tRNA-ribosyltransferase NP_438414.1 271600 R 71421 CDS NP_438415.1 16272205 949371 complement(273092..274183) 1 NC_000907.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 274183 queA 949371 queA Haemophilus influenzae Rd KW20 S-adenosylmethionine:tRNA ribosyltransferase-isomerase NP_438415.1 273092 R 71421 CDS NP_438416.1 16272206 949373 complement(274307..274753) 1 NC_000907.1 hypothetical protein 274753 949373 HI0246 Haemophilus influenzae Rd KW20 hypothetical protein NP_438416.1 274307 R 71421 CDS NP_438418.1 16272207 949621 complement(279439..282270) 1 NC_000907.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 282270 uvrA 949621 uvrA Haemophilus influenzae Rd KW20 excinuclease ABC subunit A NP_438418.1 279439 R 71421 CDS NP_438419.1 16272208 950657 282424..282930 1 NC_000907.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 282930 ssb 950657 ssb Haemophilus influenzae Rd KW20 single-stranded DNA-binding protein NP_438419.1 282424 D 71421 CDS NP_438420.1 16272209 949372 complement(283108..283920) 1 NC_000907.1 similar to GB:U04996; TonB 283920 949372 HI0251 Haemophilus influenzae Rd KW20 TonB NP_438420.1 283108 R 71421 CDS NP_438421.1 16272210 949375 complement(283930..284373) 1 NC_000907.1 similar to PID:555672 PID:1573218; biopolymer transport protein 284373 exbD 949375 exbD Haemophilus influenzae Rd KW20 biopolymer transport protein NP_438421.1 283930 R 71421 CDS NP_438422.1 16272211 949376 complement(284377..284829) 1 NC_000907.1 similar to PID:555671; transport protein ExbB 284829 exbB 949376 exbB Haemophilus influenzae Rd KW20 transport protein ExbB NP_438422.1 284377 R 71421 CDS NP_438423.1 16272212 949377 complement(284998..285465) 1 NC_000907.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 285465 bcp 949377 bcp Haemophilus influenzae Rd KW20 thioredoxin-dependent thiol peroxidase NP_438423.1 284998 R 71421 CDS NP_438424.1 16272213 949381 285566..286462 1 NC_000907.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 286462 dapA 949381 dapA Haemophilus influenzae Rd KW20 dihydrodipicolinate synthase NP_438424.1 285566 D 71421 CDS NP_438425.1 16272214 949378 286573..287220 1 NC_000907.1 similar to SP:P21167 PID:147409 PID:42126 GB:U00096 PID:1788822; lipoprotein 287220 949378 HI0256 Haemophilus influenzae Rd KW20 lipoprotein NP_438425.1 286573 D 71421 CDS NP_438426.1 16272215 949379 287390..287713 1 NC_000907.1 structural determination suggests similarity to dsRNA-binding proteins; similar to YfiA; similar to SP:P17160 GB:X05888 GB:X16334 PID:39270 PID:39276; hypothetical protein 287713 949379 HI0257 Haemophilus influenzae Rd KW20 hypothetical protein NP_438426.1 287390 D 71421 CDS NP_438427.1 16272216 949647 complement(288442..289434) 1 NC_000907.1 similar to PID:1857120; glycosyl transferase 289434 949647 HI0258 Haemophilus influenzae Rd KW20 glycosyl transferase NP_438427.1 288442 R 71421 CDS NP_438428.1 16272217 949383 complement(289511..290098) 1 NC_000907.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 290098 949383 HI0260 Haemophilus influenzae Rd KW20 deoxyribonucleotide triphosphate pyrophosphatase NP_438428.1 289511 R 71421 CDS NP_438429.1 16272218 950779 complement(290110..290835) 1 NC_000907.1 catalyzes the phosphorylation of 3-deoxy-D-manno-octulosonic acid at the 4-OH position; 3-deoxy-D-manno-octulosonic-acid kinase 290835 950779 HI0260.1 Haemophilus influenzae Rd KW20 3-deoxy-D-manno-octulosonic-acid kinase NP_438429.1 290110 R 71421 CDS NP_438430.1 16272219 950896 290912..291955 1 NC_000907.1 similar to GB:L21026 PID:311045; lipopolysaccharide biosynthesis protein 291955 950896 HI0261 Haemophilus influenzae Rd KW20 lipopolysaccharide biosynthesis protein NP_438430.1 290912 D 71421 CDS NP_438431.1 16272220 950895 292279..294450 1 NC_000907.1 similar to SP:P45357 PID:595326; heme-hemopexin utilization protein C 294450 950895 HI0262 Haemophilus influenzae Rd KW20 heme-hemopexin utilization protein C NP_438431.1 292279 D 71421 CDS NP_438432.1 16272221 949385 294525..296222 1 NC_000907.1 similar to SP:P45356 PID:1573229; heme/hemopexin-binding protein B 296222 hxuB 949385 hxuB Haemophilus influenzae Rd KW20 heme/hemopexin-binding protein B NP_438432.1 294525 D 71421 CDS NP_438433.1 16272222 949388 296234..298951 1 NC_000907.1 similar to GB:U08348 PID:540014; heme-hemopexin utilization protein A 298951 hxuA 949388 hxuA Haemophilus influenzae Rd KW20 heme-hemopexin utilization protein A NP_438433.1 296234 D 71421 CDS NP_438434.1 16272223 949403 complement(299047..299403) 1 NC_000907.1 similar to SP:P31055 PID:882580 GB:U00096 PID:1789438; dihydroneopterin aldolase 299403 949403 HI0265 Haemophilus influenzae Rd KW20 dihydroneopterin aldolase NP_438434.1 299047 R 71421 CDS NP_438435.1 16272224 949419 299486..300085 1 NC_000907.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 300085 949419 HI0266 Haemophilus influenzae Rd KW20 glycerol-3-phosphate acyltransferase PlsY NP_438435.1 299486 D 71421 CDS NP_438436.1 16272225 949389 300127..301830 1 NC_000907.1 similar to GB:M94724 SP:P27896 GB:X65714 PID:146928 PID:581139; nitrate/nitrite sensor protein NarQ 301830 narQ 949389 narQ Haemophilus influenzae Rd KW20 nitrate/nitrite sensor protein NarQ NP_438436.1 300127 D 71421 CDS NP_438437.1 16272226 949392 301840..302865 1 NC_000907.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 302865 murB 949392 murB Haemophilus influenzae Rd KW20 UDP-N-acetylenolpyruvoylglucosamine reductase NP_438437.1 301840 D 71421 CDS NP_438438.1 16272227 949393 302991..303836 1 NC_000907.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 303836 rpoH 949393 rpoH Haemophilus influenzae Rd KW20 RNA polymerase factor sigma-32 NP_438438.1 302991 D 71421 CDS NP_438439.1 16272228 950625 complement(303876..304808) 1 NC_000907.1 similar to SP:P33371 PID:405871 GB:U00096 PID:1788462; hypothetical protein 304808 950625 HI0270 Haemophilus influenzae Rd KW20 hypothetical protein NP_438439.1 303876 R 71421 CDS NP_438440.1 16272229 949410 complement(304808..305674) 1 NC_000907.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 305674 djlA 949410 djlA Haemophilus influenzae Rd KW20 Dna-J like membrane chaperone protein NP_438440.1 304808 R 71421 CDS NP_438441.1 16272230 949395 complement(305753..306394) 1 NC_000907.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 306394 pyrE 949395 pyrE Haemophilus influenzae Rd KW20 orotate phosphoribosyltransferase NP_438441.1 305753 R 71421 CDS NP_438442.1 16272231 949396 complement(306418..307134) 1 NC_000907.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 307134 rph 949396 rph Haemophilus influenzae Rd KW20 ribonuclease PH NP_438442.1 306418 R 71421 CDS NP_438443.1 16272232 949397 complement(307435..308877) 1 NC_000907.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 308877 gltX 949397 gltX Haemophilus influenzae Rd KW20 glutamyl-tRNA synthetase NP_438443.1 307435 R 71421 CDS NP_438444.1 16272233 949970 309627..311282 1 NC_000907.1 hypothetical protein 311282 949970 HI0275 Haemophilus influenzae Rd KW20 hypothetical protein NP_438444.1 309627 D 71421 CDS NP_438445.1 16272234 949791 complement(311302..312111) 1 NC_000907.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 312111 rbn 949791 rbn Haemophilus influenzae Rd KW20 ribonuclease BN NP_438445.1 311302 R 71421 CDS NP_438446.1 16272235 949404 complement(312108..312593) 1 NC_000907.1 similar to GB:L20251 SP:P37052 PID:410154 GB:U00096 PID:1787484; hypothetical protein 312593 949404 HI0277 Haemophilus influenzae Rd KW20 hypothetical protein NP_438446.1 312108 R 71421 CDS NP_438448.2 30995365 950640 313495..314253 1 NC_000907.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 314253 udp 950640 udp Haemophilus influenzae Rd KW20 uridine phosphorylase NP_438448.2 313495 D 71421 CDS NP_438449.1 16272237 950652 complement(314478..315794) 1 NC_000907.1 similar to SP:P37643 PID:466660 GB:U00096 PID:1789941; transporter 315794 950652 HI0281 Haemophilus influenzae Rd KW20 transporter NP_438449.1 314478 R 71421 CDS NP_438450.1 16272238 949409 complement(315850..316593) 1 NC_000907.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase YfbB 316593 949409 HI0282 Haemophilus influenzae Rd KW20 acyl-CoA thioester hydrolase YfbB NP_438450.1 315850 R 71421 CDS NP_438451.1 16272239 949474 complement(316654..318360) 1 NC_000907.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 318360 menD 949474 menD Haemophilus influenzae Rd KW20 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase NP_438451.1 316654 R 71421 CDS NP_438452.1 16272240 949812 complement(318376..319668) 1 NC_000907.1 synthesizes isochorismate acid from chorismate; menaquinone-specific isochorismate synthase 319668 menF 949812 menF Haemophilus influenzae Rd KW20 menaquinone-specific isochorismate synthase NP_438452.1 318376 R 71421 CDS NP_438453.1 16272241 949411 319804..321018 1 NC_000907.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 321018 949411 HI0286 Haemophilus influenzae Rd KW20 aminotransferase AlaT NP_438453.1 319804 D 71421 CDS NP_438454.1 16272242 949413 321135..322391 1 NC_000907.1 similar to GB:M58338 SP:P22306 GB:M59862 PID:146894 PID:146896; tryptophan-specific transport protein 322391 mtr 949413 mtr Haemophilus influenzae Rd KW20 tryptophan-specific transport protein NP_438454.1 321135 D 71421 CDS NP_438455.1 16272243 949415 complement(322500..323867) 1 NC_000907.1 similar to GB:M28695 SP:P16095 PID:290464 GB:U00096 PID:1736451; L-serine deaminase 323867 sdaA 949415 sdaA Haemophilus influenzae Rd KW20 L-serine deaminase NP_438455.1 322500 R 71421 CDS NP_438456.1 16272244 950177 complement(323902..325140) 1 NC_000907.1 similar to SP:P36559 GB:U01233 PID:402256 PID:882691 GB:U00096; serine transporter 325140 sdaC 950177 sdaC Haemophilus influenzae Rd KW20 serine transporter NP_438456.1 323902 R 71421 CDS NP_438457.1 16272245 949726 complement(325363..327531) 1 NC_000907.1 similar to GB:AL009126; cation-transporting ATPase 327531 949726 HI0290 Haemophilus influenzae Rd KW20 cation-transporting ATPase NP_438457.1 325363 R 71421 CDS NP_438458.1 16272246 949416 complement(327506..327712) 1 NC_000907.1 mercury transport-like protein 327712 949416 HI0291 Haemophilus influenzae Rd KW20 mercury transport-like protein NP_438458.1 327506 R 71421 CDS NP_438459.1 16272247 949615 complement(327787..327993) 1 NC_000907.1 similar to GB:X73112 PID:483769 SP:Q51770; mercuric ion scavenger protein 327993 merP 949615 merP Haemophilus influenzae Rd KW20 mercuric ion scavenger protein NP_438459.1 327787 R 71421 CDS NP_438460.1 16272248 949535 328070..328456 1 NC_000907.1 similar to GB:U00096 SP:P77565 PID:1773169 PID:1786695; MerR family transcriptional regulator 328456 949535 HI0293 Haemophilus influenzae Rd KW20 MerR family transcriptional regulator NP_438460.1 328070 D 71421 CDS NP_438461.1 16272249 949418 complement(328470..328787) 1 NC_000907.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ 328787 metJ 949418 metJ Haemophilus influenzae Rd KW20 transcriptional repressor protein MetJ NP_438461.1 328470 R 71421 CDS NP_438462.1 16272250 949491 329034..330296 1 NC_000907.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 330296 rho 949491 rho Haemophilus influenzae Rd KW20 transcription termination factor Rho NP_438462.1 329034 D 71421 CDS NP_438463.1 16272251 950669 complement(330350..331042) 1 NC_000907.1 similar to SP:P25960 GB:L28106 PID:145410 PID:451905 PID:606269; type 4 prepilin-like protein specific leader peptidase 331042 hopD 950669 hopD Haemophilus influenzae Rd KW20 type 4 prepilin-like protein specific leader peptidase NP_438463.1 330350 R 71421 CDS NP_438464.1 16272252 950200 complement(331039..332259) 1 NC_000907.1 similar to GB:M32066 SP:P22609 PID:151066; type IV pilin secretion protein 332259 950200 HI0297 Haemophilus influenzae Rd KW20 type IV pilin secretion protein NP_438464.1 331039 R 71421 CDS NP_438465.1 16272253 949957 complement(332256..333650) 1 NC_000907.1 similar to GB:M32066 SP:P22608 GB:S43866 PID:151065; protein transport protein 333650 949957 HI0298 Haemophilus influenzae Rd KW20 protein transport protein NP_438465.1 332256 R 71421 CDS NP_438466.1 16272254 949521 complement(333647..334096) 1 NC_000907.1 similar to GB:D26562 SP:P36647 GB:L28105 PID:473777 PID:456042; prepilin peptidase-dependent protein D 334096 949521 HI0299 Haemophilus influenzae Rd KW20 prepilin peptidase-dependent protein D NP_438466.1 333647 R 71421 CDS NP_438467.1 16272255 949420 334212..334766 1 NC_000907.1 similar to GB:D26562 SP:P13016 GB:L28105 GB:X15237 PID:40908; N-acetyl-anhydromuranmyl-L-alanine amidase 334766 ampD 949420 ampD Haemophilus influenzae Rd KW20 N-acetyl-anhydromuranmyl-L-alanine amidase NP_438467.1 334212 D 71421 CDS NP_438468.1 16272256 949422 335399..336298 1 NC_000907.1 similar to GB:U00096 PID:1778577 PID:1786879; hemolysin 336298 949422 HI0301 Haemophilus influenzae Rd KW20 hemolysin NP_438468.1 335399 D 71421 CDS NP_438469.2 30995366 949425 336321..337850 1 NC_000907.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 337850 lnt 949425 lnt Haemophilus influenzae Rd KW20 apolipoprotein N-acyltransferase NP_438469.2 336321 D 71421 CDS NP_438470.1 16272258 950245 337900..338637 1 NC_000907.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 338637 950245 HI0303 Haemophilus influenzae Rd KW20 16S ribosomal RNA methyltransferase RsmE NP_438470.1 337900 D 71421 CDS NP_438471.1 16272259 949387 338634..339194 1 NC_000907.1 similar to PID:882477 SP:P52049 GB:U00096 PID:1789317; hypothetical protein 339194 949387 HI0304 Haemophilus influenzae Rd KW20 hypothetical protein NP_438471.1 338634 D 71421 CDS NP_438472.1 16272260 950747 339194..339613 1 NC_000907.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 339613 950747 HI0305 Haemophilus influenzae Rd KW20 Holliday junction resolvase-like protein NP_438472.1 339194 D 71421 CDS NP_438473.1 16272261 949925 complement(339663..340571) 1 NC_000907.1 Required for efficient pilin antigenic variation; recombination associated protein 340571 rdgC 949925 rdgC Haemophilus influenzae Rd KW20 recombination associated protein NP_438473.1 339663 R 71421 CDS NP_438474.1 16272262 949427 340637..341452 1 NC_000907.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 341452 proC 949427 proC Haemophilus influenzae Rd KW20 pyrroline-5-carboxylate reductase NP_438474.1 340637 D 71421 CDS NP_438475.1 16272263 950679 341452..342618 1 NC_000907.1 transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; 3-phenylpropionic acid transporter 342618 950679 HI0308 Haemophilus influenzae Rd KW20 3-phenylpropionic acid transporter NP_438475.1 341452 D 71421 CDS NP_438476.1 16272264 949437 342649..343542 1 NC_000907.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 343542 xerD 949437 xerD Haemophilus influenzae Rd KW20 site-specific tyrosine recombinase XerD NP_438476.1 342649 D 71421 CDS NP_438477.1 16272265 949975 343715..344002 1 NC_000907.1 hypothetical protein 344002 949975 HI0310 Haemophilus influenzae Rd KW20 hypothetical protein NP_438477.1 343715 D 71421 CDS NP_438478.1 16272266 950827 complement(344054..345061) 1 NC_000907.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 345061 ruvB 950827 ruvB Haemophilus influenzae Rd KW20 Holliday junction DNA helicase RuvB NP_438478.1 344054 R 71421 CDS NP_438479.1 16272267 949429 complement(345069..345683) 1 NC_000907.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 345683 ruvA 949429 ruvA Haemophilus influenzae Rd KW20 Holliday junction DNA helicase RuvA NP_438479.1 345069 R 71421 CDS NP_438480.1 16272268 949435 complement(345746..346318) 1 NC_000907.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 346318 ruvC 949435 ruvC Haemophilus influenzae Rd KW20 Holliday junction resolvase NP_438480.1 345746 R 71421 CDS NP_438481.1 16272269 949441 complement(346365..347105) 1 NC_000907.1 similar to GB:D10165 SP:P24237 PID:216652 PID:42173 GB:U00096; hypothetical protein 347105 949441 HI0315 Haemophilus influenzae Rd KW20 hypothetical protein NP_438481.1 346365 R 71421 CDS NP_438482.2 30995367 949449 complement(347265..347729) 1 NC_000907.1 converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 347729 ntpA 949449 ntpA Haemophilus influenzae Rd KW20 dATP pyrophosphohydrolase NP_438482.2 347265 R 71421 CDS NP_438483.1 16272271 949430 complement(347763..349529) 1 NC_000907.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 349529 aspS 949430 aspS Haemophilus influenzae Rd KW20 aspartyl-tRNA synthetase NP_438483.1 347763 R 71421 CDS NP_438484.1 16272272 949431 349748..350266 1 NC_000907.1 similar to SP:P54158 PID:1256620 GB:AL009126; hypothetical protein 350266 949431 HI0318 Haemophilus influenzae Rd KW20 hypothetical protein NP_438484.1 349748 D 71421 CDS NP_438485.1 16272273 949432 350319..351044 1 NC_000907.1 YecO; contains bound cofactor S-adenosyl-L-homocysteine; similar to GB:U00096 PID:1788177; S-adenosyl-L-methionine-dependent methyltransferase 351044 yecO 949432 yecO Haemophilus influenzae Rd KW20 S-adenosyl-L-methionine-dependent methyltransferase NP_438485.1 350319 D 71421 CDS NP_438486.1 16272274 949433 351138..351374 1 NC_000907.1 similar to GB:L22308 GB:L31763 GB:M74565 PID:145069 PID:438535; virulence-associated protein B 351374 vapB 949433 vapB Haemophilus influenzae Rd KW20 virulence-associated protein B NP_438486.1 351138 D 71421 CDS NP_438487.1 16272275 949434 351371..351775 1 NC_000907.1 similar to GB:L22308 GB:L31763 GB:M74565 PID:145068 PID:438534; virulence-associated protein C 351775 949434 HI0322 Haemophilus influenzae Rd KW20 virulence-associated protein C NP_438487.1 351371 D 71421 CDS NP_438488.1 16272276 949438 351842..352249 1 NC_000907.1 similar to GB:U00096 SP:Q59384 PID:1354845 PID:1711245 PID:1787940; lactoylglutathione lyase 352249 gloA 949438 gloA Haemophilus influenzae Rd KW20 lactoylglutathione lyase NP_438488.1 351842 D 71421 CDS NP_438489.1 16272277 949924 352323..353012 1 NC_000907.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 353012 rnt 949924 rnt Haemophilus influenzae Rd KW20 ribonuclease T NP_438489.1 352323 D 71421 CDS NP_438490.1 16272278 950706 353326..354678 1 NC_000907.1 similar to GB:AL009126; hypothetical protein 354678 950706 HI0325 Haemophilus influenzae Rd KW20 hypothetical protein NP_438490.1 353326 D 71421 CDS NP_438492.3 161350014 949790 complement(355648..356214) 1 NC_000907.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 356214 efp 949790 efp Haemophilus influenzae Rd KW20 elongation factor P NP_438492.3 355648 R 71421 CDS NP_438493.1 16272281 949459 356252..357268 1 NC_000907.1 similar to GB:U14003 SP:P39280 PID:536990 GB:U00096 PID:1790589; hypothetical protein 357268 949459 HI0329 Haemophilus influenzae Rd KW20 hypothetical protein NP_438493.1 356252 D 71421 CDS NP_438494.1 16272282 949442 357367..358662 1 NC_000907.1 similar to GB:L42023 SP:P44415 PID:1003551 PID:1222255 PID:595942; opacity associated protein 358662 oapA 949442 oapA Haemophilus influenzae Rd KW20 opacity associated protein NP_438494.1 357367 D 71421 CDS NP_438495.1 16272283 950648 358722..359126 1 NC_000907.1 similar to GB:L42023 SP:P44416 PID:1003553 PID:1222256 PID:595943; opacity associated protein OapB 359126 oapB 950648 oapB Haemophilus influenzae Rd KW20 opacity associated protein OapB NP_438495.1 358722 D 71421 CDS NP_438496.1 16272284 950611 359129..359839 1 NC_000907.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 359839 recO 950611 recO Haemophilus influenzae Rd KW20 DNA repair protein RecO NP_438496.1 359129 D 71421 CDS NP_438497.1 16272285 949426 359839..361155 1 NC_000907.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 361155 rumA 949426 rumA Haemophilus influenzae Rd KW20 23S rRNA 5-methyluridine methyltransferase NP_438497.1 359839 D 71421 CDS NP_438498.1 16272286 950822 361233..363464 1 NC_000907.1 similar to GB:J04039 SP:P11585 PID:147562 PID:882678 GB:U00096; GTP pyrophosphokinase 363464 relA 950822 relA Haemophilus influenzae Rd KW20 GTP pyrophosphokinase NP_438498.1 361233 D 71421 CDS NP_438499.1 16272287 949443 363479..363835 1 NC_000907.1 similar to GB:U00006 SP:P00556 GB:K00127 PID:396377 PID:457112; diacylglycerol kinase 363835 dgkA 949443 dgkA Haemophilus influenzae Rd KW20 diacylglycerol kinase NP_438499.1 363479 D 71421 CDS NP_438500.1 16272288 949444 363918..364511 1 NC_000907.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 364511 mogA 949444 mogA Haemophilus influenzae Rd KW20 molybdenum cofactor biosynthesis protein MogA NP_438500.1 363918 D 71421 CDS NP_438501.1 16272289 949445 364513..364851 1 NC_000907.1 similar to GB:U00096 PID:1788904 PID:1799977; nitrogen regulatory protein P-II 364851 glnB 949445 glnB Haemophilus influenzae Rd KW20 nitrogen regulatory protein P-II NP_438501.1 364513 D 71421 CDS NP_438502.1 16272290 949451 364851..365897 1 NC_000907.1 similar to GB:U00096 PID:1787885; hypothetical protein 365897 949451 HI0338 Haemophilus influenzae Rd KW20 hypothetical protein NP_438502.1 364851 D 71421 CDS NP_438503.1 16272291 950761 complement(365938..368130) 1 NC_000907.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 368130 priA 950761 priA Haemophilus influenzae Rd KW20 primosome assembly protein PriA NP_438503.1 365938 R 71421 CDS NP_438504.1 16272292 949446 368213..368953 1 NC_000907.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 368953 trmB 949446 trmB Haemophilus influenzae Rd KW20 tRNA (guanine-N(7)-)-methyltransferase NP_438504.1 368213 D 71421 CDS NP_438505.1 16272293 949447 369038..369382 1 NC_000907.1 similar to SP:P38521 PID:882488 GB:U00096 PID:1789329; hypothetical protein 369382 949447 HI0341 Haemophilus influenzae Rd KW20 hypothetical protein NP_438505.1 369038 D 71421 CDS NP_438507.1 16272295 949452 370110..370391 1 NC_000907.1 similar to SP:P33938 PID:405935 GB:U00096 PID:1788535; nitrate reductase assembly protein NapD 370391 napD 949452 napD Haemophilus influenzae Rd KW20 nitrate reductase assembly protein NapD NP_438507.1 370110 D 71421 CDS NP_438509.1 16272296 950819 372967..373806 1 NC_000907.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic subunit 373806 napG 950819 napG Haemophilus influenzae Rd KW20 quinol dehydrogenase periplasmic subunit NP_438509.1 372967 D 71421 CDS NP_438510.1 16272297 949454 373806..374669 1 NC_000907.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane subunit 374669 napH 949454 napH Haemophilus influenzae Rd KW20 quinol dehydrogenase membrane subunit NP_438510.1 373806 D 71421 CDS NP_438511.1 16272298 949780 374666..375118 1 NC_000907.1 contains two heme groups; similar to SP:P33933 PID:405928 GB:U00096 PID:1788531; nitrate reductase 375118 napB 949780 napB Haemophilus influenzae Rd KW20 nitrate reductase NP_438511.1 374666 D 71421 CDS NP_438512.1 16272299 949803 375133..375735 1 NC_000907.1 similar to SP:P33932 PID:405927 GB:U00096 PID:1788530; cytochrome C-type protein 375735 napC 949803 napC Haemophilus influenzae Rd KW20 cytochrome C-type protein NP_438512.1 375133 D 71421 CDS NP_438513.1 16272300 949455 complement(375895..376539) 1 NC_000907.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 376539 adk 949455 adk Haemophilus influenzae Rd KW20 adenylate kinase NP_438513.1 375895 R 71421 CDS NP_438514.1 16272301 949456 complement(376624..377901) 1 NC_000907.1 similar to GB:U00096 SP:P36670 PID:1773117 PID:1786636 PID:563855; permease 377901 949456 HI0350 Haemophilus influenzae Rd KW20 permease NP_438514.1 376624 R 71421 CDS NP_438515.1 16272302 949642 complement(378043..379059) 1 NC_000907.1 similar to SP:P24325 GB:L42023 PID:1003592 PID:1222277 PID:43589; UDP-glucose 4-epimerase 379059 galE 949642 galE Haemophilus influenzae Rd KW20 UDP-glucose 4-epimerase NP_438515.1 378043 R 71421 CDS NP_438516.1 16272303 949950 complement(379232..379927) 1 NC_000907.1 similar to SP:P24324 GB:X57315 PID:43588; hypothetical protein 379927 949950 HI0352 Haemophilus influenzae Rd KW20 hypothetical protein NP_438516.1 379232 R 71421 CDS NP_438517.1 16272304 949457 380643..381365 1 NC_000907.1 similar to PID:1184189 GB:U00096 SP:Q47538 PID:1384059 PID:1657561; ABC transporter ATP-binding protein 381365 949457 HI0354 Haemophilus influenzae Rd KW20 ABC transporter ATP-binding protein NP_438517.1 380643 D 71421 CDS NP_438518.1 16272305 949458 381362..382099 1 NC_000907.1 similar to GB:L16808 SP:P40401 PID:438473 PID:1903040 GB:AL009126; ABC transporter permease 382099 949458 HI0355 Haemophilus influenzae Rd KW20 ABC transporter permease NP_438518.1 381362 D 71421 CDS NP_438519.1 16272306 949462 382121..383065 1 NC_000907.1 similar to SP:P42883 SP:P43534 SP:P47183 PID:1015913 PID:1302455; thiamine biosynthesis protein 383065 949462 HI0357 Haemophilus influenzae Rd KW20 thiamine biosynthesis protein NP_438519.1 382121 D 71421 CDS NP_438520.1 16272307 949463 383075..383722 1 NC_000907.1 similar to GB:AE000511 PID:2314455; transcriptional activator 383722 949463 HI0358 Haemophilus influenzae Rd KW20 transcriptional activator NP_438520.1 383075 D 71421 CDS NP_438521.1 16272308 949465 complement(383822..384637) 1 NC_000907.1 similar to PID:1245464 SP:Q56955 PID:1245467; iron (chelated) ABC transporter permease 384637 yfeD 949465 yfeD Haemophilus influenzae Rd KW20 iron (chelated) ABC transporter permease NP_438521.1 383822 R 71421 CDS NP_438522.1 16272309 950649 complement(384630..385478) 1 NC_000907.1 similar to PID:1245464 SP:Q56954 PID:1245466; iron (chelated) ABC transporter permease 385478 yfeC 950649 yfeC Haemophilus influenzae Rd KW20 iron (chelated) ABC transporter permease NP_438522.1 384630 R 71421 CDS NP_438523.1 16272310 950559 complement(385482..386402) 1 NC_000907.1 similar to PID:1245464 PID:1245465; iron (chelated) transporter ATP-binding protein 386402 yfeB 950559 yfeB Haemophilus influenzae Rd KW20 iron (chelated) transporter ATP-binding protein NP_438523.1 385482 R 71421 CDS NP_438524.1 16272311 950634 complement(386402..387283) 1 NC_000907.1 similar to PID:1245464; iron-chelated ABC transporter substrate-binding protein 387283 yfeA 950634 yfeA Haemophilus influenzae Rd KW20 iron-chelated ABC transporter substrate-binding protein NP_438524.1 386402 R 71421 CDS NP_438525.1 16272312 949374 complement(387648..388526) 1 NC_000907.1 similar to SP:P33364 GB:X01067 PID:405864 PID:808967 GB:U00096; penicillin-binding protein 7 388526 949374 HI0364 Haemophilus influenzae Rd KW20 penicillin-binding protein 7 NP_438525.1 387648 R 71421 CDS NP_438526.1 16272313 949466 388752..389924 1 NC_000907.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 389924 949466 HI0365 Haemophilus influenzae Rd KW20 ribosomal RNA large subunit methyltransferase N NP_438526.1 388752 D 71421 CDS NP_438527.1 16272314 949468 390026..390565 1 NC_000907.1 similar to PID:1162960; fimbrial biogenesis and twitching motility protein 390565 949468 HI0366 Haemophilus influenzae Rd KW20 fimbrial biogenesis and twitching motility protein NP_438527.1 390026 D 71421 CDS NP_438528.1 16272315 949469 390637..391548 1 NC_000907.1 similar to SP:P27434 GB:D21149 GB:U02965 GB:X64451 PID:41541; hypothetical protein 391548 949469 HI0367 Haemophilus influenzae Rd KW20 hypothetical protein NP_438528.1 390637 D 71421 CDS NP_438529.1 16272316 949471 391558..392664 1 NC_000907.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 392664 ispG 949471 ispG Haemophilus influenzae Rd KW20 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase NP_438529.1 391558 D 71421 CDS NP_438530.1 16272317 950203 392674..393945 1 NC_000907.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 393945 hisS 950203 hisS Haemophilus influenzae Rd KW20 histidyl-tRNA synthetase NP_438530.1 392674 D 71421 CDS NP_438531.1 16272318 949833 393962..394576 1 NC_000907.1 similar to GB:U00096 PID:1788860; hypothetical protein 394576 949833 HI0370 Haemophilus influenzae Rd KW20 hypothetical protein NP_438531.1 393962 D 71421 CDS NP_438532.1 16272319 949472 complement(394627..394821) 1 NC_000907.1 similar to SP:P37096 GB:U00096 PID:1788873; hypothetical protein 394821 949472 HI0371 Haemophilus influenzae Rd KW20 hypothetical protein NP_438532.1 394627 R 71421 CDS NP_438533.1 16272320 949473 complement(394821..395162) 1 NC_000907.1 similar to GB:M88654 SP:P25528 PID:145915 GB:U00096 PID:1788874; ferredoxin 395162 fdx-1 949473 fdx-1 Haemophilus influenzae Rd KW20 ferredoxin NP_438533.1 394821 R 71421 CDS NP_438534.1 16272321 949476 complement(395202..397061) 1 NC_000907.1 involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 397061 hscA 949476 hscA Haemophilus influenzae Rd KW20 chaperone protein HscA NP_438534.1 395202 R 71421 CDS NP_438535.1 16272322 950642 complement(397080..397766) 1 NC_000907.1 hypothetical protein 397766 950642 HI0374 Haemophilus influenzae Rd KW20 hypothetical protein NP_438535.1 397080 R 71421 CDS NP_438536.1 16272323 949448 complement(397817..398341) 1 NC_000907.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB 398341 hscB 949448 hscB Haemophilus influenzae Rd KW20 co-chaperone HscB NP_438536.1 397817 R 71421 CDS NP_438537.1 16272324 950630 complement(398354..398677) 1 NC_000907.1 similar to SP:P36539; hypothetical protein 398677 950630 HI0376 Haemophilus influenzae Rd KW20 hypothetical protein NP_438537.1 398354 R 71421 CDS NP_438538.2 30995369 949477 complement(398734..399150) 1 NC_000907.1 similar to PID:2271522; scaffold protein 399150 iscU 949477 iscU Haemophilus influenzae Rd KW20 scaffold protein NP_438538.2 398734 R 71421 CDS NP_438539.2 30995370 949479 complement(399174..400388) 1 NC_000907.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 400388 nifS 949479 nifS Haemophilus influenzae Rd KW20 cysteine desulfurase NP_438539.2 399174 R 71421 CDS NP_438540.1 16272327 949480 complement(400455..400907) 1 NC_000907.1 similar to GB:U00096 PID:1788880; hypothetical protein 400907 949480 HI0379 Haemophilus influenzae Rd KW20 hypothetical protein NP_438540.1 400455 R 71421 CDS NP_438541.1 16272328 949482 complement(400960..401685) 1 NC_000907.1 similar to GB:U00096 PID:1788881; hypothetical protein 401685 949482 HI0380 Haemophilus influenzae Rd KW20 hypothetical protein NP_438541.1 400960 R 71421 CDS NP_438542.1 16272329 949485 complement(402127..402588) 1 NC_000907.1 similar to SP:P10324 PID:1573351 SP:P10324 GB:M18878 PID:1573351; peptidoglycan-associated outer membrane lipoprotein 402588 pal 949485 pal Haemophilus influenzae Rd KW20 peptidoglycan-associated outer membrane lipoprotein NP_438542.1 402127 R 71421 CDS NP_438543.1 16272330 949486 complement(402612..403895) 1 NC_000907.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 403895 tolB 949486 tolB Haemophilus influenzae Rd KW20 translocation protein TolB NP_438543.1 402612 R 71421 CDS NP_438544.1 16272331 949487 complement(403937..405055) 1 NC_000907.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 405055 tolA 949487 tolA Haemophilus influenzae Rd KW20 cell envelope integrity inner membrane protein TolA NP_438544.1 403937 R 71421 CDS NP_438545.1 16272332 949489 complement(405071..405490) 1 NC_000907.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 405490 tolR 949489 tolR Haemophilus influenzae Rd KW20 colicin uptake protein TolR NP_438545.1 405071 R 71421 CDS NP_438546.1 16272333 950751 complement(405562..406248) 1 NC_000907.1 similar to SP:P05828 PID:1128978 GB:U00096 PID:1651329 PID:1786958; colicin transport protein 406248 tolQ 950751 tolQ Haemophilus influenzae Rd KW20 colicin transport protein NP_438546.1 405562 R 71421 CDS NP_438547.1 16272334 950554 complement(406265..406675) 1 NC_000907.1 similar to SP:P08999 PID:1128977 GB:U00096 PID:1786957; hypothetical protein 406675 950554 HI0386 Haemophilus influenzae Rd KW20 hypothetical protein NP_438547.1 406265 R 71421 CDS NP_438548.1 16272335 949750 407000..408922 1 NC_000907.1 similar to GB:U00096 PID:1736441 PID:1736447 PID:1788110; ATP-dependent helicase 408922 dinG 949750 dinG Haemophilus influenzae Rd KW20 ATP-dependent helicase NP_438548.1 407000 D 71421 CDS NP_438549.1 16272336 950019 408935..409645 1 NC_000907.1 similar to GB:U00096 SP:P76256 PID:1736440 PID:1736446 PID:1788109; hypothetical protein 409645 950019 HI0388 Haemophilus influenzae Rd KW20 hypothetical protein NP_438549.1 408935 D 71421 CDS NP_438550.1 16272337 949490 409670..410221 1 NC_000907.1 similar to GB:U00039 SP:P37194 GB:L23635 PID:387932 PID:466643; outer membrane protein 410221 949490 HI0389 Haemophilus influenzae Rd KW20 outer membrane protein NP_438550.1 409670 D 71421 CDS NP_438551.1 16272338 950680 410264..411952 1 NC_000907.1 Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 411952 fadD 950680 fadD Haemophilus influenzae Rd KW20 long-chain-fatty-acid--CoA ligase NP_438551.1 410264 D 71421 CDS NP_438552.1 16272339 950674 411952..413151 1 NC_000907.1 similar to SP:P09155 GB:X07055 GB:X70994 PID:581071 PID:581215; ribonuclease D 413151 rnd 950674 rnd Haemophilus influenzae Rd KW20 ribonuclease D NP_438552.1 411952 D 71421 CDS NP_438555.1 16272342 949492 complement(415151..416242) 1 NC_000907.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 416242 949492 HI0393 Haemophilus influenzae Rd KW20 GTP-dependent nucleic acid-binding protein EngD NP_438555.1 415151 R 71421 CDS NP_438556.1 16272343 949493 complement(416291..416875) 1 NC_000907.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 416875 pth 949493 pth Haemophilus influenzae Rd KW20 peptidyl-tRNA hydrolase NP_438556.1 416291 R 71421 CDS NP_438557.1 16272344 949524 417042..417350 1 NC_000907.1 similar to PID:1033114 SP:P52119 GB:U00096 PID:1788971; hypothetical protein 417350 949524 HI0395 Haemophilus influenzae Rd KW20 hypothetical protein NP_438557.1 417042 D 71421 CDS NP_438558.1 16272345 950708 417353..418567 1 NC_000907.1 similar to SP:P27431 GB:U00096 PID:1787373; hypothetical protein 418567 950708 HI0396 Haemophilus influenzae Rd KW20 hypothetical protein NP_438558.1 417353 D 71421 CDS NP_438559.1 16272346 949494 418569..419888 1 NC_000907.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 419888 xseA 949494 xseA Haemophilus influenzae Rd KW20 exodeoxyribonuclease VII large subunit NP_438559.1 418569 D 71421 CDS NP_438560.2 30995372 949499 420086..420718 1 NC_000907.1 similar to SP:P36651 PID:882564 GB:U00096 PID:1789412; hypothetical protein 420718 949499 HI0398 Haemophilus influenzae Rd KW20 hypothetical protein NP_438560.2 420086 D 71421 CDS NP_438561.1 16272348 949501 420728..421552 1 NC_000907.1 similar to GB:D16557 SP:P36650 PID:453396 PID:882562 GB:U00096; cyclic 3',5'-adenosine monophosphate phosphodiesterase 421552 icc 949501 icc Haemophilus influenzae Rd KW20 cyclic 3',5'-adenosine monophosphate phosphodiesterase NP_438561.1 420728 D 71421 CDS NP_438562.1 16272349 950654 complement(421650..421937) 1 NC_000907.1 similar to GB:U00096 PID:1788685; hypothetical protein 421937 950654 HI0400 Haemophilus influenzae Rd KW20 hypothetical protein NP_438562.1 421650 R 71421 CDS NP_438563.1 16272350 949945 422144..423523 1 NC_000907.1 similar to GB:M60607 SP:P10384 GB:Y00552 PID:145910 PID:41372; long-chain fatty acid transport protein 423523 fadL 949945 fadL Haemophilus influenzae Rd KW20 long-chain fatty acid transport protein NP_438563.1 422144 D 71421 CDS NP_438564.1 16272351 949561 423567..424139 1 NC_000907.1 dat1; similar to SP:P11742 GB:X15659 PID:39876 GB:AL009126; methylated-DNA-protein-cysteine methyltransferase 424139 949561 HI0402 Haemophilus influenzae Rd KW20 methylated-DNA-protein-cysteine methyltransferase NP_438564.1 423567 D 71421 CDS NP_438565.1 16272352 949640 424136..424807 1 NC_000907.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 424807 mutH 949640 mutH Haemophilus influenzae Rd KW20 DNA mismatch repair protein NP_438565.1 424136 D 71421 CDS NP_438566.1 16272353 949503 complement(424804..426096) 1 NC_000907.1 similar to GB:U00096 PID:1552765 PID:1786386 PID:971394; cell cycle protein 426096 mesJ 949503 mesJ Haemophilus influenzae Rd KW20 cell cycle protein NP_438566.1 424804 R 71421 CDS NP_438567.1 16272354 949504 complement(426096..426962) 1 NC_000907.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 426962 949504 HI0405 Haemophilus influenzae Rd KW20 pyridoxamine kinase NP_438567.1 426096 R 71421 CDS NP_438568.1 16272355 949505 complement(427035..427982) 1 NC_000907.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 427982 accA 949505 accA Haemophilus influenzae Rd KW20 acetyl-CoA carboxylase carboxyltransferase subunit alpha NP_438568.1 427035 R 71421 CDS NP_438569.1 16272356 949507 complement(428072..428857) 1 NC_000907.1 similar to PID:1054959 GB:U00096 PID:1788166; hypothetical protein 428857 949507 HI0407 Haemophilus influenzae Rd KW20 hypothetical protein NP_438569.1 428072 R 71421 CDS NP_438570.1 16272357 949513 complement(428857..429663) 1 NC_000907.1 similar to SP:P52648 GB:U00096 PID:1736501 PID:1736505 PID:1788165; ABC transporter ATP-binding protein 429663 yebM 949513 yebM Haemophilus influenzae Rd KW20 ABC transporter ATP-binding protein NP_438570.1 428857 R 71421 CDS NP_438571.1 16272358 949412 429835..431262 1 NC_000907.1 similar to GB:M77039 SP:P24204 PID:146890 PID:1054957 GB:U00096; hypothetical protein 431262 949412 HI0409 Haemophilus influenzae Rd KW20 hypothetical protein NP_438571.1 429835 D 71421 CDS NP_438572.1 16272359 950074 431377..432333 1 NC_000907.1 contains a C-terminal HTH DNA-binding domain; similar to GB:M12114 SP:P07604 PID:148092 GB:U00096 PID:1742168; transcriptional regulatory protein 432333 tyrR 950074 tyrR Haemophilus influenzae Rd KW20 transcriptional regulatory protein NP_438572.1 431377 D 71421 CDS NP_438573.1 16272360 950678 complement(432430..432705) 1 NC_000907.1 Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 432705 hfq 950678 hfq Haemophilus influenzae Rd KW20 RNA-binding protein Hfq NP_438573.1 432430 R 71421 CDS NP_438574.1 16272361 949514 complement(432796..433764) 1 NC_000907.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 433764 949514 HI0412 Haemophilus influenzae Rd KW20 23S rRNA pseudouridylate synthase C NP_438574.1 432796 R 71421 CDS NP_438575.2 30995373 949934 434185..436992 1 NC_000907.1 similar to SP:P21513 GB:X67470 GB:L23942 GB:M62747 GB:X54309; ribonuclease E 436992 rne 949934 rne Haemophilus influenzae Rd KW20 ribonuclease E NP_438575.2 434185 D 71421 CDS NP_438576.1 16272363 949402 437224..437436 1 NC_000907.1 hypothetical protein 437436 949402 HI0414 Haemophilus influenzae Rd KW20 hypothetical protein NP_438576.1 437224 D 71421 CDS NP_438577.1 16272364 949516 437760..438557 1 NC_000907.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 438557 949516 HI0415 Haemophilus influenzae Rd KW20 hydroxyethylthiazole kinase NP_438577.1 437760 D 71421 CDS NP_438578.1 16272365 949517 438550..439359 1 NC_000907.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 439359 thiD 949517 thiD Haemophilus influenzae Rd KW20 phosphomethylpyrimidine kinase NP_438578.1 438550 D 71421 CDS NP_438579.1 16272366 949518 439370..440050 1 NC_000907.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 440050 thiE 949518 thiE Haemophilus influenzae Rd KW20 thiamine-phosphate pyrophosphorylase NP_438579.1 439370 D 71421 CDS NP_438580.1 16272367 950811 439995..441338 1 NC_000907.1 similar to GB:L42023 SP:P44610 PID:1003458 PID:1222206 PID:1204537; transporter 441338 950811 HI0418 Haemophilus influenzae Rd KW20 transporter NP_438580.1 439995 D 71421 CDS NP_438581.1 16272368 949394 441507..442889 1 NC_000907.1 similar to GB:U00096 SP:P76403 PID:1736789 PID:1736801 PID:1788397; protease 442889 949394 HI0419 Haemophilus influenzae Rd KW20 protease NP_438581.1 441507 D 71421 CDS NP_438582.1 16272369 949520 443031..443330 1 NC_000907.1 hypothetical protein 443330 949520 HI0420 Haemophilus influenzae Rd KW20 hypothetical protein NP_438582.1 443031 D 71421 CDS NP_438583.1 16272370 949526 complement(444029..445348) 1 NC_000907.1 facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 445348 srmB 949526 srmB Haemophilus influenzae Rd KW20 ATP-dependent RNA helicase SrmB NP_438583.1 444029 R 71421 CDS NP_438584.1 16272371 949527 445394..446116 1 NC_000907.1 similar to SP:P31825 GB:U00096 PID:1788929; hypothetical protein 446116 949527 HI0423 Haemophilus influenzae Rd KW20 hypothetical protein NP_438584.1 445394 D 71421 CDS NP_438585.1 16272372 949529 complement(446149..447204) 1 NC_000907.1 similar to SP:P33635 GB:U00096 PID:1788935; rRNA methylase 447204 949529 HI0424 Haemophilus influenzae Rd KW20 rRNA methylase NP_438585.1 446149 R 71421 CDS NP_438586.1 16272373 950510 447351..448718 1 NC_000907.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 448718 pssA 950510 pssA Haemophilus influenzae Rd KW20 phosphatidylserine synthase NP_438586.1 447351 D 71421 CDS NP_438587.1 16272374 949831 complement(448763..449488) 1 NC_000907.1 Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 449488 fadR 949831 fadR Haemophilus influenzae Rd KW20 fatty acid metabolism regulator NP_438587.1 448763 R 71421 CDS NP_438588.2 30995374 949530 449613..451157 1 NC_000907.1 involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter 451157 nhaB 949530 nhaB Haemophilus influenzae Rd KW20 sodium/proton antiporter NP_438588.2 449613 D 71421 CDS NP_438589.1 16272376 950809 451167..451700 1 NC_000907.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 451700 dsbB 950809 dsbB Haemophilus influenzae Rd KW20 disulfide bond formation protein B NP_438589.1 451167 D 71421 CDS NP_438590.1 16272377 950659 complement(451754..453586) 1 NC_000907.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 453586 glmS 950659 glmS Haemophilus influenzae Rd KW20 glucosamine--fructose-6-phosphate aminotransferase NP_438590.1 451754 R 71421 CDS NP_438591.2 30995375 950715 complement(453698..453970) 1 NC_000907.1 similar to SP:P02342 GB:D12624 GB:X05994 PID:216565 PID:396339; DNA-binding protein HU-alpha 453970 950715 HI0430 Haemophilus influenzae Rd KW20 DNA-binding protein HU-alpha NP_438591.2 453698 R 71421 CDS NP_438592.1 16272379 950606 complement(454110..454700) 1 NC_000907.1 similar to SP:P32680 PID:396338 GB:U00096 PID:1790432; hypothetical protein 454700 950606 HI0431 Haemophilus influenzae Rd KW20 hypothetical protein NP_438592.1 454110 R 71421 CDS NP_438593.1 16272380 949531 complement(454736..455530) 1 NC_000907.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 455530 nudC 949531 nudC Haemophilus influenzae Rd KW20 NADH pyrophosphatase NP_438593.1 454736 R 71421 CDS NP_438594.1 16272381 950313 complement(455597..456193) 1 NC_000907.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; DNA uptake protein 456193 950313 HI0433 Haemophilus influenzae Rd KW20 DNA uptake protein NP_438594.1 455597 R 71421 CDS NP_438595.1 16272382 950316 complement(456269..456958) 1 NC_000907.1 similar to GB:M59751 SP:P31773 PID:1573409; competence protein F 456958 comF 950316 comF Haemophilus influenzae Rd KW20 competence protein F NP_438595.1 456269 R 71421 CDS NP_438596.1 16272383 950687 complement(456967..458304) 1 NC_000907.1 similar to GB:M62809 SP:P31772 PID:1573410; competence protein E 458304 comE 950687 comE Haemophilus influenzae Rd KW20 competence protein E NP_438596.1 456967 R 71421 CDS NP_438597.1 16272384 950663 complement(458314..458727) 1 NC_000907.1 similar to GB:M62809 SP:P31771 PID:1573411; competence protein D 458727 comD 950663 comD Haemophilus influenzae Rd KW20 competence protein D NP_438597.1 458314 R 71421 CDS NP_438598.1 16272385 950528 complement(458724..459245) 1 NC_000907.1 similar to GB:M62809 SP:P31770 PID:1573412; competence protein C 459245 comC 950528 comC Haemophilus influenzae Rd KW20 competence protein C NP_438598.1 458724 R 71421 CDS NP_438599.1 16272386 949525 complement(459242..459748) 1 NC_000907.1 similar to GB:M62809 SP:P31769 PID:1573413; competence protein B 459748 comB 949525 comB Haemophilus influenzae Rd KW20 competence protein B NP_438599.1 459242 R 71421 CDS NP_438600.1 16272387 949534 complement(459749..460546) 1 NC_000907.1 similar to GB:M62809 SP:P31768 PID:1573414; competence protein A 460546 comA 949534 comA Haemophilus influenzae Rd KW20 competence protein A NP_438600.1 459749 R 71421 CDS NP_438601.1 16272388 949537 460645..463239 1 NC_000907.1 similar to SP:P02918 GB:X02164 PID:581194 PID:606330 GB:U00096; penicillin-binding protein 1A 463239 ponA 949537 ponA Haemophilus influenzae Rd KW20 penicillin-binding protein 1A NP_438601.1 460645 D 71421 CDS NP_438602.1 16272389 949523 463327..464172 1 NC_000907.1 OrfJ; similar to GB:M62809 SP:P31777 PID:1573417; hypothetical protein 464172 949523 HI0441 Haemophilus influenzae Rd KW20 hypothetical protein NP_438602.1 463327 D 71421 CDS NP_438603.2 30995376 950773 464325..464654 1 NC_000907.1 forms homodimers; coexpressed with recR; similar to GB:M38777 SP:P17577 GB:X04487 PID:145298 PID:43322; hypothetical protein 464654 ybaB 950773 ybaB Haemophilus influenzae Rd KW20 hypothetical protein NP_438603.2 464325 D 71421 CDS NP_438604.1 16272391 949512 464716..465318 1 NC_000907.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 465318 recR 949512 recR Haemophilus influenzae Rd KW20 recombination protein RecR NP_438604.1 464716 D 71421 CDS NP_438605.1 16272392 949541 465334..467289 1 NC_000907.1 decatenates replicating daughter chromosomes; DNA topoisomerase III 467289 topB 949541 topB Haemophilus influenzae Rd KW20 DNA topoisomerase III NP_438605.1 465334 D 71421 CDS NP_438606.1 16272393 949417 467398..467736 1 NC_000907.1 similar to GB:D16463 SP:P33582 GB:U01376 PID:431135 PID:606113; preprotein translocase subunit SecG 467736 secG 949417 secG Haemophilus influenzae Rd KW20 preprotein translocase subunit SecG NP_438606.1 467398 D 71421 CDS NP_438607.1 16272394 949670 complement(468265..469935) 1 NC_000907.1 similar to SP:P20966 GB:M23196 PID:405893 PID:450372 GB:U00096; PTS system fructose-specific transporter subunit IIBC 469935 fruA 949670 fruA Haemophilus influenzae Rd KW20 PTS system fructose-specific transporter subunit IIBC NP_438607.1 468265 R 71421 CDS NP_438608.1 16272395 949542 complement(469937..470878) 1 NC_000907.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase 470878 fruK 949542 fruK Haemophilus influenzae Rd KW20 1-phosphofructokinase NP_438608.1 469937 R 71421 CDS NP_438609.1 16272396 950651 complement(470880..472379) 1 NC_000907.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; PTS system fructose-specific transporter subunit IIA/HPr protein 472379 fruB 950651 fruB Haemophilus influenzae Rd KW20 PTS system fructose-specific transporter subunit IIA/HPr protein NP_438609.1 470880 R 71421 CDS NP_438610.1 16272397 949746 complement(472451..472987) 1 NC_000907.1 hypothetical protein 472987 949746 HI0449 Haemophilus influenzae Rd KW20 hypothetical protein NP_438610.1 472451 R 71421 CDS NP_438611.1 16272398 949544 complement(473074..473349) 1 NC_000907.1 similar to GB:L22307 GB:L31763 GB:M74565 PID:145067 PID:438533; virulence-associated protein D 473349 vapD 949544 vapD Haemophilus influenzae Rd KW20 virulence-associated protein D NP_438611.1 473074 R 71421 CDS NP_438612.1 16272399 950826 complement(473358..473549) 1 NC_000907.1 similar to PID:1196479; hypothetical protein 473549 950826 HI0451 Haemophilus influenzae Rd KW20 hypothetical protein NP_438612.1 473358 R 71421 CDS NP_438613.1 16272400 949660 complement(473621..474919) 1 NC_000907.1 similar to GB:U14003 SP:P39319 PID:537059 GB:U00096 PID:1790664; hypothetical protein 474919 949660 HI0452 Haemophilus influenzae Rd KW20 hypothetical protein NP_438613.1 473621 R 71421 CDS NP_438614.1 16272401 949624 complement(474970..475494) 1 NC_000907.1 similar to GB:AE000511 PID:2313105; hypothetical protein 475494 949624 HI0453 Haemophilus influenzae Rd KW20 hypothetical protein NP_438614.1 474970 R 71421 CDS NP_438615.1 16272402 949545 complement(475521..476303) 1 NC_000907.1 similar to SP:P37346 GB:U00096 PID:1787342; hypothetical protein 476303 949545 HI0454 Haemophilus influenzae Rd KW20 hypothetical protein NP_438615.1 475521 R 71421 CDS NP_438616.1 16272403 949546 complement(476358..477341) 1 NC_000907.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 477341 holB 949546 holB Haemophilus influenzae Rd KW20 DNA polymerase III subunit delta' NP_438616.1 476358 R 71421 CDS NP_438617.2 30995377 949547 complement(477338..477997) 1 NC_000907.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 477997 tmk 949547 tmk Haemophilus influenzae Rd KW20 thymidylate kinase NP_438617.2 477338 R 71421 CDS NP_438618.1 16272405 950653 complement(477987..479030) 1 NC_000907.1 similar to GB:U00096 PID:1510185 PID:1787339; hypothetical protein 479030 950653 HI0457 Haemophilus influenzae Rd KW20 hypothetical protein NP_438618.1 477987 R 71421 CDS NP_438619.1 16272406 949829 complement(479100..480041) 1 NC_000907.1 similar to SP:P21202 GB:M68521 PID:147119 PID:216478 GB:U00096; stationary-phase survival protein SurA 480041 949829 HI0458 Haemophilus influenzae Rd KW20 stationary-phase survival protein SurA NP_438619.1 479100 R 71421 CDS NP_438620.1 16272407 949777 complement(480112..480651) 1 NC_000907.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase 480651 pyrR 949777 pyrR Haemophilus influenzae Rd KW20 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase NP_438620.1 480112 R 71421 CDS NP_438621.1 16272408 949607 480783..481574 1 NC_000907.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase 481574 mazG 949607 mazG Haemophilus influenzae Rd KW20 nucleoside triphosphate pyrophosphohydrolase NP_438621.1 480783 D 71421 CDS NP_438622.1 16272409 949548 complement(481624..482499) 1 NC_000907.1 similar to SP:P32181; hypothetical protein 482499 949548 HI0461 Haemophilus influenzae Rd KW20 hypothetical protein NP_438622.1 481624 R 71421 CDS NP_438623.1 16272410 949549 482692..485103 1 NC_000907.1 similar to GB:M38347 SP:P08177 GB:J03896 GB:L12349 GB:L20572; ATP-dependent proteinase 485103 lon 949549 lon Haemophilus influenzae Rd KW20 ATP-dependent proteinase NP_438623.1 482692 D 71421 CDS NP_438624.1 16272411 949551 485219..486370 1 NC_000907.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 486370 949551 HI0463 Haemophilus influenzae Rd KW20 coproporphyrinogen III oxidase NP_438624.1 485219 D 71421 CDS NP_438625.1 16272412 949550 486503..487162 1 NC_000907.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 487162 rpiA 949550 rpiA Haemophilus influenzae Rd KW20 ribose-5-phosphate isomerase A NP_438625.1 486503 D 71421 CDS NP_438626.1 16272413 950636 487192..488424 1 NC_000907.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 488424 serA 950636 serA Haemophilus influenzae Rd KW20 D-3-phosphoglycerate dehydrogenase NP_438626.1 487192 D 71421 CDS NP_438627.1 16272414 949552 complement(488468..489310) 1 NC_000907.1 similar to PID:887848 GB:U00096 SP:P39179 PID:1789265; hypothetical protein 489310 949552 HI0466 Haemophilus influenzae Rd KW20 hypothetical protein NP_438627.1 488468 R 71421 CDS NP_438628.3 161350015 949553 complement(489320..490183) 1 NC_000907.1 similar to GB:L10328 SP:P23839 GB:X14235 PID:290494 PID:42721; hypothetical protein 490183 949553 HI0467 Haemophilus influenzae Rd KW20 hypothetical protein NP_438628.3 489320 R 71421 CDS NP_438629.1 16272416 949555 490631..491542 1 NC_000907.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 491542 hisG 949555 hisG Haemophilus influenzae Rd KW20 ATP phosphoribosyltransferase NP_438629.1 490631 D 71421 CDS NP_438630.1 16272417 949557 491635..492918 1 NC_000907.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 492918 hisD 949557 hisD Haemophilus influenzae Rd KW20 histidinol dehydrogenase NP_438630.1 491635 D 71421 CDS NP_438631.1 16272418 949558 492987..494090 1 NC_000907.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 494090 hisC 949558 hisC Haemophilus influenzae Rd KW20 histidinol-phosphate aminotransferase NP_438631.1 492987 D 71421 CDS NP_438632.1 16272419 949564 494202..495290 1 NC_000907.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 495290 hisB 949564 hisB Haemophilus influenzae Rd KW20 imidazole glycerol-phosphate dehydratase/histidinol phosphatase NP_438632.1 494202 D 71421 CDS NP_438633.1 16272420 949532 495356..495955 1 NC_000907.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 495955 hisH 949532 hisH Haemophilus influenzae Rd KW20 imidazole glycerol phosphate synthase subunit HisH NP_438633.1 495356 D 71421 CDS NP_438634.1 16272421 949519 495991..496740 1 NC_000907.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 496740 hisA 949519 hisA Haemophilus influenzae Rd KW20 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase NP_438634.1 495991 D 71421 CDS NP_438635.1 16272422 949565 496722..497498 1 NC_000907.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 497498 hisF 949565 hisF Haemophilus influenzae Rd KW20 imidazole glycerol phosphate synthase subunit HisF NP_438635.1 496722 D 71421 CDS NP_438636.1 16272423 949566 497498..498163 1 NC_000907.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase 498163 hisIE 949566 hisIE Haemophilus influenzae Rd KW20 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase NP_438636.1 497498 D 71421 CDS NP_438637.1 16272424 950656 498427..499629 1 NC_000907.1 similar to GB:M23240 SP:P18199 PID:148089 GB:U00096 PID:1736569; tyrosine-specific transport protein 499629 tyrP 950656 tyrP Haemophilus influenzae Rd KW20 tyrosine-specific transport protein NP_438637.1 498427 D 71421 CDS NP_438638.1 16272425 950629 complement(499815..500243) 1 NC_000907.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 500243 atpC 950629 atpC Haemophilus influenzae Rd KW20 F0F1 ATP synthase subunit epsilon NP_438638.1 499815 R 71421 CDS NP_438639.1 16272426 950675 complement(500273..501646) 1 NC_000907.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 501646 atpD 950675 atpD Haemophilus influenzae Rd KW20 F0F1 ATP synthase subunit beta NP_438639.1 500273 R 71421 CDS NP_438640.1 16272427 949567 complement(501663..502532) 1 NC_000907.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 502532 atpG 949567 atpG Haemophilus influenzae Rd KW20 F0F1 ATP synthase subunit gamma NP_438640.1 501663 R 71421 CDS NP_438641.1 16272428 950615 complement(502548..504089) 1 NC_000907.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 504089 atpA 950615 atpA Haemophilus influenzae Rd KW20 F0F1 ATP synthase subunit alpha NP_438641.1 502548 R 71421 CDS NP_438642.1 16272429 949424 complement(504102..504635) 1 NC_000907.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 504635 atpH 949424 atpH Haemophilus influenzae Rd KW20 F0F1 ATP synthase subunit delta NP_438642.1 504102 R 71421 CDS NP_438643.1 16272430 949543 complement(504648..505118) 1 NC_000907.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 505118 atpF 949543 atpF Haemophilus influenzae Rd KW20 F0F1 ATP synthase subunit B NP_438643.1 504648 R 71421 CDS NP_438644.1 16272431 949568 complement(505168..505422) 1 NC_000907.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 505422 atpE 949568 atpE Haemophilus influenzae Rd KW20 F0F1 ATP synthase subunit C NP_438644.1 505168 R 71421 CDS NP_438645.1 16272432 949858 complement(505478..506266) 1 NC_000907.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 506266 atpB 949858 atpB Haemophilus influenzae Rd KW20 F0F1 ATP synthase subunit A NP_438645.1 505478 R 71421 CDS NP_438646.1 16272433 950693 complement(506303..506677) 1 NC_000907.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I 506677 950693 HI0485.1 Haemophilus influenzae Rd KW20 F0F1 ATP synthase subunit I NP_438646.1 506303 R 71421 CDS NP_438647.1 16272434 950623 complement(506803..507414) 1 NC_000907.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 507414 gidB 950623 gidB Haemophilus influenzae Rd KW20 16S rRNA methyltransferase GidB NP_438647.1 506803 R 71421 CDS NP_438648.1 16272435 950695 complement(507554..507931) 1 NC_000907.1 hypothetical protein 507931 950695 HI0487 Haemophilus influenzae Rd KW20 hypothetical protein NP_438648.1 507554 R 71421 CDS NP_438649.1 16272436 949569 508047..508649 1 NC_000907.1 similar to GB:U00096 PID:1789046; phosphatase/phosphohexomutase 508649 949569 HI0488 Haemophilus influenzae Rd KW20 phosphatase/phosphohexomutase NP_438649.1 508047 D 71421 CDS NP_438650.1 16272437 949626 508649..509122 1 NC_000907.1 similar to GB:U00096 PID:1789045; hypothetical protein 509122 949626 HI0489 Haemophilus influenzae Rd KW20 hypothetical protein NP_438650.1 508649 D 71421 CDS NP_438651.1 16272438 950775 509452..509955 1 NC_000907.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 509955 luxS 950775 luxS Haemophilus influenzae Rd KW20 S-ribosylhomocysteinase NP_438651.1 509452 D 71421 CDS NP_438652.1 16272439 949783 510454..510810 1 NC_000907.1 similar to GB:M29945 PID:1197032; hypothetical protein 510810 949783 HI0493 Haemophilus influenzae Rd KW20 hypothetical protein NP_438652.1 510454 D 71421 CDS NP_438653.1 16273634 950561 complement(join(510901..511410,511409..511609)) 1 NC_000907.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 511609 aphA 950561 aphA Haemophilus influenzae Rd KW20 acid phosphatase/phosphotransferase NP_438653.1 510901 R 71421 CDS NP_438654.1 16272440 949571 511828..512355 1 NC_000907.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 512355 hslV 949571 hslV Haemophilus influenzae Rd KW20 ATP-dependent protease peptidase subunit NP_438654.1 511828 D 71421 CDS NP_438655.1 16272441 950614 512366..513700 1 NC_000907.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 513700 hslU 950614 hslU Haemophilus influenzae Rd KW20 ATP-dependent protease ATP-binding subunit HslU NP_438655.1 512366 D 71421 CDS NP_438656.2 30995379 950055 complement(513770..514822) 1 NC_000907.1 similar to GB:M64519 SP:P23861 PID:147329 GB:U00096 PID:1651550; spermidine/putrescine ABC transporter substrate-binding protein 514822 potD 950055 potD Haemophilus influenzae Rd KW20 spermidine/putrescine ABC transporter substrate-binding protein NP_438656.2 513770 R 71421 CDS NP_438657.1 16272443 949572 514963..516258 1 NC_000907.1 similar to GB:M38433 SP:P37906 PID:1054921 PID:551780 GB:U00096; oxidoreductase 516258 949572 HI0499 Haemophilus influenzae Rd KW20 oxidoreductase NP_438657.1 514963 D 71421 CDS NP_438658.2 30995380 949635 516703..517866 1 NC_000907.1 similar to GB:M87049 SP:P27850 PID:148230 GB:U00096 PID:1790266; hypothetical protein 517866 949635 HI0500 Haemophilus influenzae Rd KW20 hypothetical protein NP_438658.2 516703 D 71421 CDS NP_438659.1 16272445 949497 518034..518453 1 NC_000907.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 518453 rbsD 949497 rbsD Haemophilus influenzae Rd KW20 D-ribose pyranase NP_438659.1 518034 D 71421 CDS NP_438660.1 16272446 950602 518467..519948 1 NC_000907.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP binding protein 519948 rbsA 950602 rbsA Haemophilus influenzae Rd KW20 D-ribose transporter ATP binding protein NP_438660.1 518467 D 71421 CDS NP_438661.1 16272447 949666 519961..520932 1 NC_000907.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 520932 rbsC 949666 rbsC Haemophilus influenzae Rd KW20 ribose ABC transporter permease NP_438661.1 519961 D 71421 CDS NP_438662.1 16272448 949573 520952..521830 1 NC_000907.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 521830 rbsB 949573 rbsB Haemophilus influenzae Rd KW20 D-ribose transporter subunit RbsB NP_438662.1 520952 D 71421 CDS NP_438663.1 16272449 949575 521928..522848 1 NC_000907.1 catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 522848 rbsK 949575 rbsK Haemophilus influenzae Rd KW20 ribokinase NP_438663.1 521928 D 71421 CDS NP_438664.1 16272450 949576 522876..523874 1 NC_000907.1 similar to GB:L10328 SP:P25551 GB:D10466 GB:M13169 PID:147517; RBS repressor 523874 rbsR 949576 rbsR Haemophilus influenzae Rd KW20 RBS repressor NP_438664.1 522876 D 71421 CDS NP_438665.1 16272451 949655 523980..524531 1 NC_000907.1 similar to PID:882531 SP:P52082 GB:U00096 PID:1789376; hypothetical protein 524531 949655 HI0507 Haemophilus influenzae Rd KW20 hypothetical protein NP_438665.1 523980 D 71421 CDS NP_438666.1 16272452 949667 complement(524671..525159) 1 NC_000907.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 525159 menG 949667 menG Haemophilus influenzae Rd KW20 ribonuclease activity regulator protein RraA NP_438666.1 524671 R 71421 CDS NP_438667.2 30995381 949923 complement(525211..526122) 1 NC_000907.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 526122 menA 949923 menA Haemophilus influenzae Rd KW20 1,4-dihydroxy-2-naphthoate octaprenyltransferase NP_438667.2 525211 R 71421 CDS NP_438668.1 16272454 949577 526184..526903 1 NC_000907.1 similar to GB:D15061 SP:P28634 PID:303558 GB:U00096 PID:1552771; hypothetical protein 526903 949577 HI0510 Haemophilus influenzae Rd KW20 hypothetical protein NP_438668.1 526184 D 71421 CDS NP_438669.1 16272455 950588 complement(526956..527942) 1 NC_000907.1 similar to GB:M74072 SP:P25396 PID:149017 GB:U00096 PID:1742325; potassium-tellurite ethidium and proflavin transporter 527942 950588 HI0511 Haemophilus influenzae Rd KW20 potassium-tellurite ethidium and proflavin transporter NP_438669.1 526956 R 71421 CDS NP_438670.1 16272456 950710 complement(528159..528935) 1 NC_000907.1 HincIIR; HindIIR; binds gtyrac palindromes as a dimer; similar to GB:X52124 SP:P17743 PID:1573497; type II restriction endonuclease 528935 hindIIR 950710 hindIIR Haemophilus influenzae Rd KW20 type II restriction endonuclease NP_438670.1 528159 R 71421 CDS NP_438671.1 16272457 950799 complement(528932..530488) 1 NC_000907.1 similar to SP:P17744; modification methylase 530488 hindIIM 950799 hindIIM Haemophilus influenzae Rd KW20 modification methylase NP_438671.1 528932 R 71421 CDS NP_438672.1 16272458 949579 complement(530561..534808) 1 NC_000907.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 534808 rpoC 949579 rpoC Haemophilus influenzae Rd KW20 DNA-directed RNA polymerase subunit beta' NP_438672.1 530561 R 71421 CDS NP_438673.1 16272459 949581 complement(535050..539081) 1 NC_000907.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 539081 rpoB 949581 rpoB Haemophilus influenzae Rd KW20 DNA-directed RNA polymerase subunit beta NP_438673.1 535050 R 71421 CDS NP_438674.1 16272460 949582 complement(539465..540154) 1 NC_000907.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 540154 rplA 949582 rplA Haemophilus influenzae Rd KW20 50S ribosomal protein L1 NP_438674.1 539465 R 71421 CDS NP_438675.1 16272461 949669 complement(540159..540587) 1 NC_000907.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 540587 rplK 949669 rplK Haemophilus influenzae Rd KW20 50S ribosomal protein L11 NP_438675.1 540159 R 71421 CDS NP_438676.1 16272462 949650 complement(540760..541476) 1 NC_000907.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 541476 deoD 949650 deoD Haemophilus influenzae Rd KW20 purine nucleoside phosphorylase NP_438676.1 540760 R 71421 CDS NP_438677.1 16272463 949656 complement(541560..542813) 1 NC_000907.1 similar to GB:AE000511 PID:2314337; transporter 542813 949656 HI0519 Haemophilus influenzae Rd KW20 transporter NP_438677.1 541560 R 71421 CDS NP_438678.1 16272464 949583 complement(542912..543700) 1 NC_000907.1 similar to GB:U14003 SP:P39409 PID:537219 GB:U00096 PID:1790839; hypothetical protein 543700 949583 HI0520 Haemophilus influenzae Rd KW20 hypothetical protein NP_438678.1 542912 R 71421 CDS NP_438679.1 16272465 950665 complement(543709..545253) 1 NC_000907.1 similar to GB:U14003 SP:P37342 PID:537220 GB:U00096 PID:1790840; hypothetical protein 545253 950665 HI0521 Haemophilus influenzae Rd KW20 hypothetical protein NP_438679.1 543709 R 71421 CDS NP_438680.1 16272466 950631 545466..546122 1 NC_000907.1 similar to GB:D26185 SP:P37505 PID:467358 GB:AL009126; hypothetical protein 546122 950631 HI0522 Haemophilus influenzae Rd KW20 hypothetical protein NP_438680.1 545466 D 71421 CDS NP_438681.2 30995382 950662 complement(546078..547118) 1 NC_000907.1 similar to GB:AE000511 PID:2314449; heptosyltransferase-like protein 547118 950662 HI0523 Haemophilus influenzae Rd KW20 heptosyltransferase-like protein NP_438681.2 546078 R 71421 CDS NP_438682.1 16272468 949539 complement(547186..548265) 1 NC_000907.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 548265 fba 949539 fba Haemophilus influenzae Rd KW20 fructose-bisphosphate aldolase NP_438682.1 547186 R 71421 CDS NP_438683.1 16272469 949587 complement(548376..549536) 1 NC_000907.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 549536 pgk 949587 pgk Haemophilus influenzae Rd KW20 phosphoglycerate kinase NP_438683.1 548376 R 71421 CDS NP_438684.1 16272470 949589 complement(549638..550456) 1 NC_000907.1 hypothetical protein 550456 949589 HI0526 Haemophilus influenzae Rd KW20 hypothetical protein NP_438684.1 549638 R 71421 CDS NP_438685.1 16272471 949590 550534..550794 1 NC_000907.1 similar to SP:P00208; ferredoxin 550794 fdx-2 949590 fdx-2 Haemophilus influenzae Rd KW20 ferredoxin NP_438685.1 550534 D 71421 CDS NP_438686.1 16272472 949591 complement(550936..552156) 1 NC_000907.1 similar to GB:M23240 SP:P18199 PID:148089 GB:U00096 PID:1736569; tyrosine-specific transport protein 552156 tyrP 949591 tyrP Haemophilus influenzae Rd KW20 tyrosine-specific transport protein NP_438686.1 550936 R 71421 CDS NP_438687.2 30995383 949592 complement(552193..552744) 1 NC_000907.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 552744 tdk 949592 tdk Haemophilus influenzae Rd KW20 thymidine kinase NP_438687.2 552193 R 71421 CDS NP_438688.1 16272474 950725 complement(552783..553811) 1 NC_000907.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 553811 gcp 950725 gcp Haemophilus influenzae Rd KW20 DNA-binding/iron metalloprotein/AP endonuclease NP_438688.1 552783 R 71421 CDS NP_438689.1 16272475 950699 554043..554258 1 NC_000907.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 554258 rpsU 950699 rpsU Haemophilus influenzae Rd KW20 30S ribosomal protein S21 NP_438689.1 554043 D 71421 CDS NP_438690.1 16272476 949627 554392..556173 1 NC_000907.1 synthesizes RNA primers at the replication forks; DNA primase 556173 dnaG 949627 dnaG Haemophilus influenzae Rd KW20 DNA primase NP_438690.1 554392 D 71421 CDS NP_438691.1 16272477 949596 556243..558132 1 NC_000907.1 similar to GB:J01687 SP:P00579 PID:147756 PID:882590 PID:1072030; RNA polymerase sigma-70 factor 558132 rpoD 949596 rpoD Haemophilus influenzae Rd KW20 RNA polymerase sigma-70 factor NP_438691.1 556243 D 71421 CDS NP_438692.1 16272478 949597 complement(558436..559863) 1 NC_000907.1 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 559863 aspA 949597 aspA Haemophilus influenzae Rd KW20 aspartate ammonia-lyase NP_438692.1 558436 R 71421 CDS NP_438693.1 16272479 949674 complement(560041..560826) 1 NC_000907.1 similar to GB:M84338 SP:Q09067 PID:485336 PID:1247672 GB:AE000511; urease accessory protein 560826 ureH 949674 ureH Haemophilus influenzae Rd KW20 urease accessory protein NP_438693.1 560041 R 71421 CDS NP_438694.1 16272480 950530 complement(560901..561578) 1 NC_000907.1 similar to GB:M84338 SP:Q09066 PID:485335 PID:1247672 GB:AE000511; urease accessory protein 561578 ureG 950530 ureG Haemophilus influenzae Rd KW20 urease accessory protein NP_438694.1 560901 R 71421 CDS NP_438695.2 30995384 949598 complement(561681..562388) 1 NC_000907.1 similar to SP:Q07402 PID:393298; urease accessory protein UreF 562388 ureF 949598 ureF Haemophilus influenzae Rd KW20 urease accessory protein UreF NP_438695.2 561681 R 71421 CDS NP_438696.1 16272482 949599 complement(562373..562930) 1 NC_000907.1 involved in the assembly of the urease metallocenter; possible nickel donor; urease accessory protein UreE 562930 ureE 949599 ureE Haemophilus influenzae Rd KW20 urease accessory protein UreE NP_438696.1 562373 R 71421 CDS NP_438697.1 16272483 950768 complement(563058..564776) 1 NC_000907.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 564776 ureC 950768 ureC Haemophilus influenzae Rd KW20 urease subunit alpha NP_438697.1 563058 R 71421 CDS NP_438698.1 16272484 950763 complement(564788..565093) 1 NC_000907.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active; urease subunit beta 565093 ureB 950763 ureB Haemophilus influenzae Rd KW20 urease subunit beta NP_438698.1 564788 R 71421 CDS NP_438699.1 16272485 949600 complement(565169..565471) 1 NC_000907.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 565471 ureA 949600 ureA Haemophilus influenzae Rd KW20 urease subunit gamma NP_438699.1 565169 R 71421 CDS NP_438700.1 16272486 949601 565634..565924 1 NC_000907.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 565924 groES 949601 groES Haemophilus influenzae Rd KW20 co-chaperonin GroES NP_438700.1 565634 D 71421 CDS NP_438701.1 16272487 950072 565947..567593 1 NC_000907.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 567593 groEL 950072 groEL Haemophilus influenzae Rd KW20 chaperonin GroEL NP_438701.1 565947 D 71421 CDS NP_438702.1 16272488 950774 complement(567767..568216) 1 NC_000907.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 568216 rplI 950774 rplI Haemophilus influenzae Rd KW20 50S ribosomal protein L9 NP_438702.1 567767 R 71421 CDS NP_438703.1 16272489 950770 complement(568233..568460) 1 NC_000907.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 568460 rpsR 950770 rpsR Haemophilus influenzae Rd KW20 30S ribosomal protein S18 NP_438703.1 568233 R 71421 CDS NP_438704.2 161350027 949533 complement(568473..568799) 1 NC_000907.1 binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 568799 949533 HI0546 Haemophilus influenzae Rd KW20 primosomal replication protein N NP_438704.2 568473 R 71421 CDS NP_438705.1 16272491 949602 complement(568786..569163) 1 NC_000907.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 569163 rpsF 949602 rpsF Haemophilus influenzae Rd KW20 30S ribosomal protein S6 NP_438705.1 568786 R 71421 CDS NP_438706.2 30995385 949386 complement(569362..569580) 1 NC_000907.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 569580 infA 949386 infA Haemophilus influenzae Rd KW20 translation initiation factor IF-1 NP_438706.2 569362 R 71421 CDS NP_438707.1 16272493 949586 569786..570649 1 NC_000907.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 570649 ksgA 949586 ksgA Haemophilus influenzae Rd KW20 dimethyladenosine transferase NP_438707.1 569786 D 71421 CDS NP_438708.1 16272494 949673 complement(570690..571598) 1 NC_000907.1 similar to GB:X56903 GB:L19441; lipooligosaccharide biosynthesis protein 571598 949673 HI0550 Haemophilus influenzae Rd KW20 lipooligosaccharide biosynthesis protein NP_438708.1 570690 R 71421 CDS NP_438709.1 16272495 950805 571717..572544 1 NC_000907.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 572544 apaH 950805 apaH Haemophilus influenzae Rd KW20 diadenosine tetraphosphatase NP_438709.1 571717 D 71421 CDS NP_438710.1 16272496 949603 572554..573177 1 NC_000907.1 hypothetical protein 573177 949603 HI0552 Haemophilus influenzae Rd KW20 hypothetical protein NP_438710.1 572554 D 71421 CDS NP_438711.1 16272497 949604 complement(573303..574757) 1 NC_000907.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 574757 gnd 949604 gnd Haemophilus influenzae Rd KW20 6-phosphogluconate dehydrogenase NP_438711.1 573303 R 71421 CDS NP_438712.1 16272498 949606 complement(575203..575745) 1 NC_000907.1 hypothetical protein 575745 949606 HI0554 Haemophilus influenzae Rd KW20 hypothetical protein NP_438712.1 575203 R 71421 CDS NP_438713.1 16272499 950248 complement(575870..576109) 1 NC_000907.1 similar to GB:M87483 SP:Q02009 PID:551879; hypothetical protein 576109 950248 HI0555 Haemophilus influenzae Rd KW20 hypothetical protein NP_438713.1 575870 R 71421 CDS NP_438715.1 16272501 949608 complement(576891..578375) 1 NC_000907.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 578375 zwf 949608 zwf Haemophilus influenzae Rd KW20 glucose-6-phosphate 1-dehydrogenase NP_438715.1 576891 R 71421 CDS NP_438716.1 16272502 949609 complement(578451..579137) 1 NC_000907.1 similar to SP:P22255 GB:M55170 GB:M80795 PID:145275 PID:145690; sulfite synthesis pathway protein 579137 cysQ 949609 cysQ Haemophilus influenzae Rd KW20 sulfite synthesis pathway protein NP_438716.1 578451 R 71421 CDS NP_438717.1 16272503 949585 complement(579332..579679) 1 NC_000907.1 hypothetical protein 579679 949585 HI0559.1 Haemophilus influenzae Rd KW20 hypothetical protein NP_438717.1 579332 R 71421 CDS NP_438718.1 16272504 950224 complement(579736..581637) 1 NC_000907.1 similar to PID:1655665; hypothetical protein 581637 950224 HI0561 Haemophilus influenzae Rd KW20 hypothetical protein NP_438718.1 579736 R 71421 CDS NP_438719.1 16272505 949610 581951..582346 1 NC_000907.1 similar to SP:P45802 PID:606334 GB:U00096 PID:1789803; hypothetical protein 582346 949610 HI0562 Haemophilus influenzae Rd KW20 hypothetical protein NP_438719.1 581951 D 71421 CDS NP_438720.1 16272506 950765 complement(582372..582824) 1 NC_000907.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 582824 asnC 950765 asnC Haemophilus influenzae Rd KW20 DNA-binding transcriptional regulator AsnC NP_438720.1 582372 R 71421 CDS NP_438721.1 16272507 949631 582978..583970 1 NC_000907.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 583970 asnA 949631 asnA Haemophilus influenzae Rd KW20 asparagine synthetase AsnA NP_438721.1 582978 D 71421 CDS NP_438722.1 16272508 949611 complement(584035..584709) 1 NC_000907.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 584709 gph 949611 gph Haemophilus influenzae Rd KW20 phosphoglycolate phosphatase NP_438722.1 584035 R 71421 CDS NP_438723.2 30995386 949612 complement(584755..585429) 1 NC_000907.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 585429 dod 949612 dod Haemophilus influenzae Rd KW20 ribulose-phosphate 3-epimerase NP_438723.2 584755 R 71421 CDS NP_438724.1 16272510 949613 complement(585576..587996) 1 NC_000907.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 587996 gyrB 949613 gyrB Haemophilus influenzae Rd KW20 DNA gyrase subunit B NP_438724.1 585576 R 71421 CDS NP_438725.1 16272511 949614 complement(588147..590435) 1 NC_000907.1 similar to SP:Q45388 PID:1477402; transcription accessory protein 590435 tex 949614 tex Haemophilus influenzae Rd KW20 transcription accessory protein NP_438725.1 588147 R 71421 CDS NP_438726.1 16272512 950647 590531..591007 1 NC_000907.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 591007 greB 950647 greB Haemophilus influenzae Rd KW20 transcription elongation factor GreB NP_438726.1 590531 D 71421 CDS NP_438727.1 16272513 949502 complement(591078..591695) 1 NC_000907.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 591695 949502 HI0570 Haemophilus influenzae Rd KW20 DNA-binding transcriptional repressor FabR NP_438727.1 591078 R 71421 CDS NP_438728.1 16272514 950698 complement(591695..592600) 1 NC_000907.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 592600 oxyR 950698 oxyR Haemophilus influenzae Rd KW20 DNA-binding transcriptional regulator OxyR NP_438728.1 591695 R 71421 CDS NP_438729.1 16272515 950101 592723..593448 1 NC_000907.1 contains peroxiredoxin and glutaredoxin domains; forms homotetramers; similar to PID:1652858; peroxiredoxin hybrid Prx5 593448 950101 HI0572 Haemophilus influenzae Rd KW20 peroxiredoxin hybrid Prx5 NP_438729.1 592723 D 71421 CDS NP_438730.1 16272516 949619 complement(593536..593757) 1 NC_000907.1 similar to GB:L13261 SP:P30857 PID:290468 PID:606282 GB:U00096; hypothetical protein 593757 slyX 949619 slyX Haemophilus influenzae Rd KW20 hypothetical protein NP_438730.1 593536 R 71421 CDS NP_438731.1 16272517 949620 593855..594580 1 NC_000907.1 similar to SP:P45523 SP:P45527 PID:606281 PID:862300 GB:U00096; FKBP-type peptidyl-prolyl cis-trans isomerase 594580 fkpA 949620 fkpA Haemophilus influenzae Rd KW20 FKBP-type peptidyl-prolyl cis-trans isomerase NP_438731.1 593855 D 71421 CDS NP_438732.1 16272518 950683 594669..595334 1 NC_000907.1 similar to SP:P45533 PID:606280 GB:U00096 PID:1789744; hypothetical protein 595334 950683 HI0575 Haemophilus influenzae Rd KW20 hypothetical protein NP_438732.1 594669 D 71421 CDS NP_438733.1 16272519 950688 595334..595714 1 NC_000907.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 595714 950688 HI0576 Haemophilus influenzae Rd KW20 sulfur transfer complex subunit TusD NP_438733.1 595334 D 71421 CDS NP_438734.1 16272520 950759 595711..596070 1 NC_000907.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC 596070 950759 HI0576.1 Haemophilus influenzae Rd KW20 sulfur relay protein TusC NP_438734.1 595711 D 71421 CDS NP_438735.1 16272521 949622 596079..596366 1 NC_000907.1 hypothetical protein 596366 949622 HI0577 Haemophilus influenzae Rd KW20 hypothetical protein NP_438735.1 596079 D 71421 CDS NP_438736.1 16272522 949623 complement(596497..597681) 1 NC_000907.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 597681 tuf 949623 tuf Haemophilus influenzae Rd KW20 elongation factor Tu NP_438736.1 596497 R 71421 CDS NP_438737.1 16272523 950282 complement(597746..599848) 1 NC_000907.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 599848 fusA 950282 fusA Haemophilus influenzae Rd KW20 elongation factor G NP_438737.1 597746 R 71421 CDS NP_438738.1 16272524 949475 complement(599932..600402) 1 NC_000907.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 600402 rpS7 949475 rpS7 Haemophilus influenzae Rd KW20 30S ribosomal protein S7 NP_438738.1 599932 R 71421 CDS NP_438739.1 16272525 949625 complement(600559..600933) 1 NC_000907.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 600933 rpsL 949625 rpsL Haemophilus influenzae Rd KW20 30S ribosomal protein S12 NP_438739.1 600559 R 71421 CDS NP_438740.1 16272526 950589 complement(601115..603004) 1 NC_000907.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 603004 gidA 950589 gidA Haemophilus influenzae Rd KW20 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA NP_438740.1 601115 R 71421 CDS NP_438741.1 16272527 949588 complement(603690..605663) 1 NC_000907.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase 605663 cpdB 949588 cpdB Haemophilus influenzae Rd KW20 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase NP_438741.1 603690 R 71421 CDS NP_438742.1 16272528 950603 complement(605757..607028) 1 NC_000907.1 similar to GB:U00096 SP:P77357 PID:1742205 PID:1742209 PID:1787599; hydrolase 607028 950603 HI0584 Haemophilus influenzae Rd KW20 hydrolase NP_438742.1 605757 R 71421 CDS NP_438745.2 30995387 949646 complement(608461..609117) 1 NC_000907.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E 609117 pepE 949646 pepE Haemophilus influenzae Rd KW20 peptidase E NP_438745.2 608461 R 71421 CDS NP_438746.1 16272532 950643 609241..610476 1 NC_000907.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase 610476 950643 HI0588 Haemophilus influenzae Rd KW20 allantoate amidohydrolase NP_438746.1 609241 D 71421 CDS NP_438747.1 16272533 949630 610691..611110 1 NC_000907.1 similar to SP:P46187 PID:987645 PID:1045631 PID:1050877 GB:U00096; sigma factor regulatory protein 611110 949630 HI0589 Haemophilus influenzae Rd KW20 sigma factor regulatory protein NP_438747.1 610691 D 71421 CDS NP_438748.1 16272534 950609 complement(611212..612519) 1 NC_000907.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter 612519 potE 950609 potE Haemophilus influenzae Rd KW20 putrescine transporter NP_438748.1 611212 R 71421 CDS NP_438749.1 16272535 949823 complement(612624..614786) 1 NC_000907.1 similar to GB:M64495 SP:P24169 PID:147331 GB:U00096 PID:1651300; ornithine decarboxylase 614786 speF 949823 speF Haemophilus influenzae Rd KW20 ornithine decarboxylase NP_438749.1 612624 R 71421 CDS NP_438751.1 16272537 949632 complement(615772..617301) 1 NC_000907.1 similar to GB:AE000783; hypothetical protein 617301 949632 HI0594 Haemophilus influenzae Rd KW20 hypothetical protein NP_438751.1 615772 R 71421 CDS NP_438752.1 16272538 949637 complement(617406..618338) 1 NC_000907.1 reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 618338 arcC 949637 arcC Haemophilus influenzae Rd KW20 carbamate kinase NP_438752.1 617406 R 71421 CDS NP_438753.1 16272539 950778 complement(618348..619352) 1 NC_000907.1 similar to GB:X05637 SP:P08308 PID:45288; ornithine carbamoyltransferase 619352 arcB 950778 arcB Haemophilus influenzae Rd KW20 ornithine carbamoyltransferase NP_438753.1 618348 R 71421 CDS NP_438754.1 16272540 950123 619754..620572 1 NC_000907.1 similar to SP:P27848; hypothetical protein 620572 950123 HI0597 Haemophilus influenzae Rd KW20 hypothetical protein NP_438754.1 619754 D 71421 CDS NP_438755.1 16272541 949807 620572..621054 1 NC_000907.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 621054 ccrB 949807 ccrB Haemophilus influenzae Rd KW20 camphor resistance protein CrcB NP_438755.1 620572 D 71421 CDS NP_438756.2 161350026 949641 complement(620954..621412) 1 NC_000907.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 621412 recX 949641 recX Haemophilus influenzae Rd KW20 recombination regulator RecX NP_438756.2 620954 R 71421 CDS NP_438757.1 16272543 949644 complement(621492..622556) 1 NC_000907.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 622556 recA 949644 recA Haemophilus influenzae Rd KW20 recombinase A NP_438757.1 621492 R 71421 CDS NP_438758.1 16272544 949645 622876..623529 1 NC_000907.1 similar to GB:U13205 PID:1573592; DNA transformation protein 623529 tfoX 949645 tfoX Haemophilus influenzae Rd KW20 DNA transformation protein NP_438758.1 622876 D 71421 CDS NP_438760.1 16272545 949653 complement(630346..631632) 1 NC_000907.1 similar to GB:M87049 SP:P09128 GB:X12614 PID:148201 PID:41669; protoheme synthesis protein HemY 631632 hemY 949653 hemY Haemophilus influenzae Rd KW20 protoheme synthesis protein HemY NP_438760.1 630346 R 71421 CDS NP_438761.2 30995388 949795 complement(join(631643..632173,632173..632856)) 1 NC_000907.1 heme biosynthesis-like protein 632856 hemX 949795 hemX Haemophilus influenzae Rd KW20 heme biosynthesis-like protein NP_438761.2 631643 R 71421 CDS NP_438762.1 16272546 950010 633161..635692 1 NC_000907.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 635692 cyaA 950010 cyaA Haemophilus influenzae Rd KW20 adenylate cyclase NP_438762.1 633161 D 71421 CDS NP_438763.1 16272547 949436 635766..636773 1 NC_000907.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 636773 gpsA 949436 gpsA Haemophilus influenzae Rd KW20 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase NP_438763.1 635766 D 71421 CDS NP_438764.1 16272548 949654 636785..637588 1 NC_000907.1 catalyzes the O-acetylation of serine; serine acetyltransferase 637588 cysE 949654 cysE Haemophilus influenzae Rd KW20 serine acetyltransferase NP_438764.1 636785 D 71421 CDS NP_438765.1 16272549 949659 637598..638413 1 NC_000907.1 catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 638413 aroE 949659 aroE Haemophilus influenzae Rd KW20 shikimate 5-dehydrogenase NP_438765.1 637598 D 71421 CDS NP_438766.1 16272550 949996 638552..639937 1 NC_000907.1 similar to GB:L77117 SP:Q58086 PID:1591386; di- and tricarboxylate transporter 639937 949996 HI0608 Haemophilus influenzae Rd KW20 di- and tricarboxylate transporter NP_438766.1 638552 D 71421 CDS NP_438767.1 16272551 950705 complement(640075..640923) 1 NC_000907.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 640923 folD 950705 folD Haemophilus influenzae Rd KW20 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase NP_438767.1 640075 R 71421 CDS NP_438768.1 16272552 950599 complement(641451..642737) 1 NC_000907.1 similar to SP:P11551 GB:X15025 PID:146041 PID:41504 PID:882696; L-fucose permease 642737 fucP 950599 fucP Haemophilus influenzae Rd KW20 L-fucose permease NP_438768.1 641451 R 71421 CDS NP_438769.1 16272553 950000 complement(642776..643426) 1 NC_000907.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 643426 fucA 950000 fucA Haemophilus influenzae Rd KW20 L-fuculose phosphate aldolase NP_438769.1 642776 R 71421 CDS NP_438770.1 16272554 949663 complement(643446..643880) 1 NC_000907.1 similar to PID:882699 GB:U00096 PID:1789169; fucose operon protein 643880 fucU 949663 fucU Haemophilus influenzae Rd KW20 fucose operon protein NP_438770.1 643446 R 71421 CDS NP_438771.1 16272555 950556 complement(643894..645306) 1 NC_000907.1 similar to SP:P11553 GB:X15025 PID:41506 PID:882698 GB:U00096; L-fuculokinase 645306 fucK 950556 fucK Haemophilus influenzae Rd KW20 L-fuculokinase NP_438771.1 643894 R 71421 CDS NP_438772.2 30995389 950887 complement(645379..647148) 1 NC_000907.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 647148 fucI 950887 fucI Haemophilus influenzae Rd KW20 L-fucose isomerase NP_438772.2 645379 R 71421 CDS NP_438773.1 16272557 949664 complement(647375..648124) 1 NC_000907.1 similar to SP:P11554 GB:X15025 PID:41508 PID:882700 GB:U00096; L-fucose operon activator 648124 fucR 949664 fucR Haemophilus influenzae Rd KW20 L-fucose operon activator NP_438773.1 647375 R 71421 CDS NP_438774.1 16272558 949665 648322..651093 1 NC_000907.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA 651093 hepA 949665 hepA Haemophilus influenzae Rd KW20 ATP-dependent helicase HepA NP_438774.1 648322 D 71421 CDS NP_438775.1 16272559 950684 651096..651755 1 NC_000907.1 similar to SP:P39219 GB:U00096 PID:1786244; hypothetical protein 651755 950684 HI0617 Haemophilus influenzae Rd KW20 hypothetical protein NP_438775.1 651096 D 71421 CDS NP_438776.1 16272560 950685 651782..652360 1 NC_000907.1 similar to GB:M54940 SP:P09391 GB:M96795 PID:146185 PID:146193; glp protein 652360 950685 HI0618 Haemophilus influenzae Rd KW20 glp protein NP_438776.1 651782 D 71421 CDS NP_438777.1 16272561 950682 652390..653157 1 NC_000907.1 similar to SP:P09392 GB:M96795 PID:146186 PID:606358 GB:U00096; glycerol-3-phosphate regulon repressor 653157 glpR 950682 glpR Haemophilus influenzae Rd KW20 glycerol-3-phosphate regulon repressor NP_438777.1 652390 D 71421 CDS NP_438778.1 16272562 950676 complement(653459..654280) 1 NC_000907.1 similar to GB:M59804 SP:P31728 PID:1573614; D-methionine-binding lipoprotein MetQ 654280 hlpA 950676 hlpA Haemophilus influenzae Rd KW20 D-methionine-binding lipoprotein MetQ NP_438778.1 653459 R 71421 CDS NP_438780.1 16272563 950557 complement(654999..656036) 1 NC_000907.1 part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding protein 656036 metN 950557 metN Haemophilus influenzae Rd KW20 DL-methionine transporter ATP-binding protein NP_438780.1 654999 R 71421 CDS NP_438781.1 16272564 949688 656212..656766 1 NC_000907.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 656766 949688 HI0621.1 Haemophilus influenzae Rd KW20 D,D-heptose 1,7-bisphosphate phosphatase NP_438781.1 656212 D 71421 CDS NP_438782.1 16272565 949678 662609..663118 1 NC_000907.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 663118 def 949678 def Haemophilus influenzae Rd KW20 peptide deformylase NP_438782.1 662609 D 71421 CDS NP_438783.1 16272566 949680 663211..664167 1 NC_000907.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 664167 fmt 949680 fmt Haemophilus influenzae Rd KW20 methionyl-tRNA formyltransferase NP_438783.1 663211 D 71421 CDS NP_438784.1 16272567 949681 664167..665522 1 NC_000907.1 similar to SP:P36929 SP:P36929 GB:X52114 PID:43136 PID:443992; sun protein 665522 sun 949681 sun Haemophilus influenzae Rd KW20 sun protein NP_438784.1 664167 D 71421 CDS NP_438785.1 16272568 949682 665535..666911 1 NC_000907.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 666911 trkA 949682 trkA Haemophilus influenzae Rd KW20 potassium transporter peripheral membrane component NP_438785.1 665535 D 71421 CDS NP_438786.1 16272569 950793 666984..667370 1 NC_000907.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 667370 mscL 950793 mscL Haemophilus influenzae Rd KW20 large-conductance mechanosensitive channel NP_438786.1 666984 D 71421 CDS NP_438787.1 16272570 950813 667460..667717 1 NC_000907.1 similar to PID:887847 GB:U00096 SP:Q46825 PID:1789264; hypothetical protein 667717 950813 HI0627 Haemophilus influenzae Rd KW20 hypothetical protein NP_438787.1 667460 D 71421 CDS NP_438788.1 16272571 950801 667825..668394 1 NC_000907.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 668394 rpoE 950801 rpoE Haemophilus influenzae Rd KW20 RNA polymerase sigma factor RpoE NP_438788.1 667825 D 71421 CDS NP_438789.1 16272572 949684 668419..669006 1 NC_000907.1 similar to SP:P38106 GB:U10148 GB:U00096 PID:1788925 PID:987647; sigma-E factor negative regulatory protein 669006 mclA 949684 mclA Haemophilus influenzae Rd KW20 sigma-E factor negative regulatory protein NP_438789.1 668419 D 71421 CDS NP_438790.1 16272573 949706 669086..670033 1 NC_000907.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; negative regulator of sigmaE 670033 rseB 949706 rseB Haemophilus influenzae Rd KW20 negative regulator of sigmaE NP_438790.1 669086 D 71421 CDS NP_438791.1 16272574 949538 complement(670124..671059) 1 NC_000907.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 671059 coaA 949538 coaA Haemophilus influenzae Rd KW20 pantothenate kinase NP_438791.1 670124 R 71421 CDS NP_438792.1 16272575 950329 671764..672948 1 NC_000907.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 672948 tuf 950329 tuf Haemophilus influenzae Rd KW20 elongation factor Tu NP_438792.1 671764 D 71421 CDS NP_438793.2 30995390 950781 673116..673493 1 NC_000907.1 hypothetical protein 673493 950781 HI0633 Haemophilus influenzae Rd KW20 hypothetical protein NP_438793.2 673116 D 71421 CDS NP_438794.1 16272577 950134 673496..674479 1 NC_000907.1 similar to SP:P32695 PID:396384 GB:U00096 PID:1790483; tRNA-dihydrouridine synthase A 674479 950134 HI0634 Haemophilus influenzae Rd KW20 tRNA-dihydrouridine synthase A NP_438794.1 673496 D 71421 CDS NP_438795.2 30995391 950591 complement(674692..677850) 1 NC_000907.1 similar to PID:1000292 PID:984513; hemoglobin-binding protein 677850 950591 HI0635 Haemophilus influenzae Rd KW20 hemoglobin-binding protein NP_438795.2 674692 R 71421 CDS NP_438796.1 16272579 949687 complement(678239..678529) 1 NC_000907.1 similar to GB:U00096 PID:1788685; hypothetical protein 678529 949687 HI0636 Haemophilus influenzae Rd KW20 hypothetical protein NP_438796.1 678239 R 71421 CDS NP_438797.1 16272580 949689 complement(678551..679555) 1 NC_000907.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 679555 trpS 949689 trpS Haemophilus influenzae Rd KW20 tryptophanyl-tRNA synthetase NP_438797.1 678551 R 71421 CDS NP_438798.1 16272581 950538 679684..680301 1 NC_000907.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 680301 950538 HI0638 Haemophilus influenzae Rd KW20 hypothetical protein NP_438798.1 679684 D 71421 CDS NP_438799.1 16272582 949686 680324..681694 1 NC_000907.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 681694 purB 949686 purB Haemophilus influenzae Rd KW20 adenylosuccinate lyase NP_438799.1 680324 D 71421 CDS NP_438800.1 16272583 950716 681966..682457 1 NC_000907.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 682457 rplJ 950716 rplJ Haemophilus influenzae Rd KW20 50S ribosomal protein L10 NP_438800.1 681966 D 71421 CDS NP_438801.1 16272584 949690 682512..682883 1 NC_000907.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 682883 rplL 949690 rplL Haemophilus influenzae Rd KW20 50S ribosomal protein L7/L12 NP_438801.1 682512 D 71421 CDS NP_438802.1 16272585 949691 683043..684413 1 NC_000907.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 684413 glmU 949691 glmU Haemophilus influenzae Rd KW20 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase NP_438802.1 683043 D 71421 CDS YP_008530233.1 542123258 16830694 complement(684452..684763) 1 NC_000907.1 hypothetical protein 684763 16830694 HI0642a Haemophilus influenzae Rd KW20 hypothetical protein YP_008530233.1 684452 R 71421 CDS NP_438803.1 16272586 950790 complement(685466..687943) 1 NC_000907.1 similar to SP:P46923 PID:1045667 GB:U00096 PID:1736518 PID:1736526; biotin sulfoxide reductase 687943 bisC 950790 bisC Haemophilus influenzae Rd KW20 biotin sulfoxide reductase NP_438803.1 685466 R 71421 CDS NP_438804.2 30995392 950598 complement(687976..689076) 1 NC_000907.1 similar to SP:P52005 GB:U00096 PID:1736519 PID:1736527 PID:1788181; cytochrome C-like protein 689076 yecK 950598 yecK Haemophilus influenzae Rd KW20 cytochrome C-like protein NP_438804.2 687976 R 71421 CDS NP_438805.1 16272588 949694 complement(689231..690172) 1 NC_000907.1 similar to PID:1449198; lysophospholipase L2 690172 pldB 949694 pldB Haemophilus influenzae Rd KW20 lysophospholipase L2 NP_438805.1 689231 R 71421 CDS NP_438806.1 16272589 949960 complement(690227..691342) 1 NC_000907.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 691342 asd 949960 asd Haemophilus influenzae Rd KW20 aspartate-semialdehyde dehydrogenase NP_438806.1 690227 R 71421 CDS NP_438807.1 16272590 949408 complement(691501..692217) 1 NC_000907.1 similar to GB:M57715 SP:P22037 PID:154179; transporter 692217 949408 HI0647 Haemophilus influenzae Rd KW20 transporter NP_438807.1 691501 R 71421 CDS NP_438808.2 30995393 949679 complement(692495..693073) 1 NC_000907.1 similar to SP:P40717 PID:609328 PID:882558 GB:U00096 PID:1789406; modulator of drug activity B 693073 mdaB 949679 mdaB Haemophilus influenzae Rd KW20 modulator of drug activity B NP_438808.2 692495 R 71421 CDS NP_438809.1 16272592 949695 complement(693363..695375) 1 NC_000907.1 similar to GB:M87049 SP:P09980 GB:X04794 PID:148182 GB:U00096; ATP-dependent DNA helicase 695375 rep 949695 rep Haemophilus influenzae Rd KW20 ATP-dependent DNA helicase NP_438809.1 693363 R 71421 CDS NP_438810.1 16272593 949696 complement(695381..695593) 1 NC_000907.1 hypothetical protein 695593 949696 HI0650 Haemophilus influenzae Rd KW20 hypothetical protein NP_438810.1 695381 R 71421 CDS NP_438811.1 16272594 949693 complement(695590..696060) 1 NC_000907.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 696060 coaD 949693 coaD Haemophilus influenzae Rd KW20 phosphopantetheine adenylyltransferase NP_438811.1 695590 R 71421 CDS NP_438812.1 16272595 949683 complement(696057..697340) 1 NC_000907.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 697340 kdtA 949683 kdtA Haemophilus influenzae Rd KW20 3-deoxy-D-manno-octulosonic-acid transferase NP_438812.1 696057 R 71421 CDS NP_438813.1 16272596 950619 697403..698167 1 NC_000907.1 similar to PID:1389735; lipopolysaccharide biosynthesis protein 698167 950619 HI0653 Haemophilus influenzae Rd KW20 lipopolysaccharide biosynthesis protein NP_438813.1 697403 D 71421 CDS NP_438814.1 16272597 949931 complement(698164..698721) 1 NC_000907.1 similar to SP:P05100 GB:J02606 GB:X03845 PID:147920 PID:43030; DNA-3-methyladenine glycosylase 698721 tagI 949931 tagI Haemophilus influenzae Rd KW20 DNA-3-methyladenine glycosylase NP_438814.1 698164 R 71421 CDS NP_438815.1 16272598 949697 complement(698718..699536) 1 NC_000907.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 699536 aroE 949697 aroE Haemophilus influenzae Rd KW20 shikimate 5-dehydrogenase NP_438815.1 698718 R 71421 CDS NP_438816.1 16272599 950161 complement(699540..700091) 1 NC_000907.1 similar to SP:P45748 PID:606216 GB:U00096 PID:2367210; hypothetical protein 700091 950161 HI0656 Haemophilus influenzae Rd KW20 hypothetical protein NP_438816.1 699540 R 71421 CDS NP_438817.1 16272600 949423 complement(700107..700643) 1 NC_000907.1 similar to SP:P45771 PID:606217 GB:U00096 PID:1789677; hypothetical protein 700643 949423 HI0656.1 Haemophilus influenzae Rd KW20 hypothetical protein NP_438817.1 700107 R 71421 CDS NP_438818.1 16272601 949699 complement(700653..702569) 1 NC_000907.1 similar to SP:P45535 PID:606286 GB:U00096 PID:1789751; ABC transporter ATP-binding protein 702569 949699 HI0658 Haemophilus influenzae Rd KW20 ABC transporter ATP-binding protein NP_438818.1 700653 R 71421 CDS NP_438819.1 16272602 949700 complement(702730..703026) 1 NC_000907.1 HTH-type transcriptional regulator 703026 949700 HI0659 Haemophilus influenzae Rd KW20 HTH-type transcriptional regulator NP_438819.1 702730 R 71421 CDS NP_438820.1 16272603 950644 complement(703019..703378) 1 NC_000907.1 hypothetical protein 703378 950644 HI0660 Haemophilus influenzae Rd KW20 hypothetical protein NP_438820.1 703019 R 71421 CDS NP_438821.1 16272604 949701 complement(703648..706680) 1 NC_000907.1 similar to PID:1000292 PID:984513; hemoglobin-binding protein 706680 oapA 949701 oapA Haemophilus influenzae Rd KW20 hemoglobin-binding protein NP_438821.1 703648 R 71421 CDS NP_438822.1 16273636 949702 707165..708910 1 NC_000907.1 ABC transporter ATP-binding protein 708910 cydD 949702 cydD Haemophilus influenzae Rd KW20 ABC transporter ATP-binding protein NP_438822.1 707165 D 71421 CDS NP_438823.1 16272605 949703 708903..710561 1 NC_000907.1 similar to GB:AL009126; ABC transporter ATP-binding protein 710561 949703 HI0664 Haemophilus influenzae Rd KW20 ABC transporter ATP-binding protein NP_438823.1 708903 D 71421 CDS NP_438824.1 16272606 949704 complement(710645..711676) 1 NC_000907.1 hypothetical protein 711676 949704 HI0665 Haemophilus influenzae Rd KW20 hypothetical protein NP_438824.1 710645 R 71421 CDS NP_438825.1 16272607 949708 complement(711673..711993) 1 NC_000907.1 hypothetical protein 711993 949708 HI0666 Haemophilus influenzae Rd KW20 hypothetical protein NP_438825.1 711673 R 71421 CDS NP_438826.1 16272608 949707 complement(711981..712289) 1 NC_000907.1 hypothetical protein 712289 949707 HI0666.1 Haemophilus influenzae Rd KW20 hypothetical protein NP_438826.1 711981 R 71421 CDS NP_438827.1 16272609 949705 complement(712489..713490) 1 NC_000907.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 713490 glpX 949705 glpX Haemophilus influenzae Rd KW20 fructose 1,6-bisphosphatase II NP_438827.1 712489 R 71421 CDS NP_438828.1 16272610 949710 713652..713870 1 NC_000907.1 similar to GB:L19201 SP:P32164 PID:305031 GB:U00096 PID:1790363; hypothetical protein 713870 949710 HI0668 Haemophilus influenzae Rd KW20 hypothetical protein NP_438828.1 713652 D 71421 CDS NP_438829.1 16272611 949711 713967..714407 1 NC_000907.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 714407 mioC 949711 mioC Haemophilus influenzae Rd KW20 flavodoxin NP_438829.1 713967 D 71421 CDS NP_438830.1 16272612 949713 714404..714838 1 NC_000907.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 714838 949713 HI0670 Haemophilus influenzae Rd KW20 D-tyrosyl-tRNA(Tyr) deacylase NP_438830.1 714404 D 71421 CDS NP_438831.1 16272613 950633 complement(715140..715616) 1 NC_000907.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 715616 ispF 950633 ispF Haemophilus influenzae Rd KW20 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase NP_438831.1 715140 R 71421 CDS NP_438832.1 16272614 950888 complement(715613..716290) 1 NC_000907.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 716290 ispD 950888 ispD Haemophilus influenzae Rd KW20 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NP_438832.1 715613 R 71421 CDS NP_438833.1 16272615 950558 complement(716290..716568) 1 NC_000907.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB 716568 ftsB 950558 ftsB Haemophilus influenzae Rd KW20 cell division protein FtsB NP_438833.1 716290 R 71421 CDS NP_438834.1 16272616 949714 complement(716691..717158) 1 NC_000907.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 717158 gptA 949714 gptA Haemophilus influenzae Rd KW20 xanthine-guanine phosphoribosyltransferase NP_438834.1 716691 R 71421 CDS NP_438835.1 16272617 950737 717269..718723 1 NC_000907.1 similar to GB:M34034 SP:P15288 GB:X14790 PID:1208983 PID:147140; aminoacyl-histidine dipeptidase 718723 pepD 950737 pepD Haemophilus influenzae Rd KW20 aminoacyl-histidine dipeptidase NP_438835.1 717269 D 71421 CDS NP_438836.1 16272618 950745 complement(718776..719663) 1 NC_000907.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 719663 xerC 950745 xerC Haemophilus influenzae Rd KW20 site-specific tyrosine recombinase XerC NP_438836.1 718776 R 71421 CDS NP_438837.1 16272619 950735 complement(719657..720097) 1 NC_000907.1 hypothetical protein 720097 950735 HI0677 Haemophilus influenzae Rd KW20 hypothetical protein NP_438837.1 719657 R 71421 CDS NP_438838.1 16272620 950739 720263..721054 1 NC_000907.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 721054 tpiA 950739 tpiA Haemophilus influenzae Rd KW20 triosephosphate isomerase NP_438838.1 720263 D 71421 CDS NP_438839.1 16272621 949715 complement(721137..721454) 1 NC_000907.1 similar to GB:X07520 SP:P09390 GB:M96795 PID:146184 PID:146192; thiosulfate sulfurtransferase GlpE 721454 glpE 949715 glpE Haemophilus influenzae Rd KW20 thiosulfate sulfurtransferase GlpE NP_438839.1 721137 R 71421 CDS NP_438840.1 16272622 949717 complement(721436..722332) 1 NC_000907.1 similar to SP:P27844; RarD protein 722332 949717 HI0680 Haemophilus influenzae Rd KW20 RarD protein NP_438840.1 721436 R 71421 CDS NP_438841.1 16272623 949718 complement(722364..723242) 1 NC_000907.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 723242 ilvY 949718 ilvY Haemophilus influenzae Rd KW20 DNA-binding transcriptional regulator IlvY NP_438841.1 722364 R 71421 CDS NP_438842.1 16272624 949478 723919..725397 1 NC_000907.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 725397 ilvC 949478 ilvC Haemophilus influenzae Rd KW20 ketol-acid reductoisomerase NP_438842.1 723919 D 71421 CDS NP_438843.1 16272625 949971 complement(725508..726788) 1 NC_000907.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 726788 glpC 949971 glpC Haemophilus influenzae Rd KW20 sn-glycerol-3-phosphate dehydrogenase subunit C NP_438843.1 725508 R 71421 CDS NP_438844.1 16272626 950690 complement(726800..728098) 1 NC_000907.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 728098 glpB 950690 glpB Haemophilus influenzae Rd KW20 anaerobic glycerol-3-phosphate dehydrogenase subunit B NP_438844.1 726800 R 71421 CDS NP_438845.1 16272627 949605 complement(728088..729779) 1 NC_000907.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 729779 glpA 949605 glpA Haemophilus influenzae Rd KW20 sn-glycerol-3-phosphate dehydrogenase subunit A NP_438845.1 728088 R 71421 CDS NP_438846.1 16272628 949719 730072..731514 1 NC_000907.1 similar to SP:P08194 GB:Y00536 PID:41587 GB:U00096 PID:1788573; glycerol-3-phosphatase transporter 731514 glpT 949719 glpT Haemophilus influenzae Rd KW20 glycerol-3-phosphatase transporter NP_438846.1 730072 D 71421 CDS NP_438847.1 16272629 949720 731614..732528 1 NC_000907.1 similar to GB:D26185 SP:P37511 PID:467365 GB:AL009126; hypothetical protein 732528 949720 HI0687 Haemophilus influenzae Rd KW20 hypothetical protein NP_438847.1 731614 D 71421 CDS NP_438848.1 16272630 949721 732623..732934 1 NC_000907.1 hypothetical protein 732934 949721 HI0688 Haemophilus influenzae Rd KW20 hypothetical protein NP_438848.1 732623 D 71421 CDS NP_438849.1 16272631 949981 732946..734040 1 NC_000907.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase 734040 glpQ 949981 glpQ Haemophilus influenzae Rd KW20 glycerophosphodiester phosphodiesterase NP_438849.1 732946 D 71421 CDS NP_438850.1 16272632 949956 734270..735064 1 NC_000907.1 similar to GB:L19201 SP:P11244 GB:M55990 GB:U13915 GB:X15054; glycerol uptake facilitator protein 735064 glpF 949956 glpF Haemophilus influenzae Rd KW20 glycerol uptake facilitator protein NP_438850.1 734270 D 71421 CDS NP_438851.1 16272633 949976 735085..736596 1 NC_000907.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 736596 glpK 949976 glpK Haemophilus influenzae Rd KW20 glycerol kinase NP_438851.1 735085 D 71421 CDS NP_438852.1 16272634 949722 complement(736671..737138) 1 NC_000907.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 737138 gptB 949722 gptB Haemophilus influenzae Rd KW20 xanthine-guanine phosphoribosyltransferase NP_438852.1 736671 R 71421 CDS NP_438853.1 16272635 949723 737422..738246 1 NC_000907.1 similar to GB:M68502 SP:P26093 PID:1573696; lipoprotein E 738246 hel 949723 hel Haemophilus influenzae Rd KW20 lipoprotein E NP_438853.1 737422 D 71421 CDS NP_438854.1 16272636 950211 738386..739108 1 NC_000907.1 similar to GB:U00096 SP:P75966 PID:1787380; hypothetical protein 739108 950211 HI0694 Haemophilus influenzae Rd KW20 hypothetical protein NP_438854.1 738386 D 71421 CDS NP_438855.1 16272637 950213 complement(739234..740205) 1 NC_000907.1 similar to GB:L06129 SP:P29014 PID:147343 GB:U00096 PID:1788848; exopolyphosphatase 740205 950213 HI0695 Haemophilus influenzae Rd KW20 exopolyphosphatase NP_438855.1 739234 R 71421 CDS NP_438856.1 16272638 950032 complement(740213..744109) 1 NC_000907.1 similar to GB:U14003 SP:P39321 PID:537063 GB:U00096; hypothetical protein 744109 950032 HI0696 Haemophilus influenzae Rd KW20 hypothetical protein NP_438856.1 740213 R 71421 CDS NP_438857.1 16272639 950204 complement(744119..745855) 1 NC_000907.1 similar to GB:U14003 SP:P39320 PID:537061 GB:U00096 PID:1790666; hypothetical protein 745855 950204 HI0698 Haemophilus influenzae Rd KW20 hypothetical protein NP_438857.1 744119 R 71421 CDS NP_438858.1 16272640 949724 complement(746006..746578) 1 NC_000907.1 similar to GB:L13261 SP:P30856 GB:Z21496 PID:394720 PID:475995; peptidyl-prolyl cis-trans isomerase 746578 slyD 949724 slyD Haemophilus influenzae Rd KW20 peptidyl-prolyl cis-trans isomerase NP_438858.1 746006 R 71421 CDS NP_438859.1 16272641 949725 complement(746658..747119) 1 NC_000907.1 similar to SP:P37163 GB:U14003 PID:537096 GB:U00096 PID:1790704; hypothetical protein 747119 949725 HI0700 Haemophilus influenzae Rd KW20 hypothetical protein NP_438859.1 746658 R 71421 CDS NP_438860.1 16272642 949727 747228..748247 1 NC_000907.1 catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D 748247 truD 949727 truD Haemophilus influenzae Rd KW20 tRNA pseudouridine synthase D NP_438860.1 747228 D 71421 CDS NP_438861.1 16272643 949728 748257..749006 1 NC_000907.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 749006 surE 949728 surE Haemophilus influenzae Rd KW20 stationary phase survival protein SurE NP_438861.1 748257 D 71421 CDS NP_438862.1 16272644 949729 749015..749593 1 NC_000907.1 similar to GB:L10653 SP:P36684 PID:148929; lipoprotein B 749593 lppB 949729 lppB Haemophilus influenzae Rd KW20 lipoprotein B NP_438862.1 749015 D 71421 CDS NP_438863.1 16272645 949730 749602..749787 1 NC_000907.1 hypothetical protein 749787 949730 HI0704 Haemophilus influenzae Rd KW20 hypothetical protein NP_438863.1 749602 D 71421 CDS NP_438864.1 16272646 949731 749811..751028 1 NC_000907.1 similar to GB:L07869 SP:P33648 PID:404099 PID:433185 PID:882635; lipoprotein 751028 949731 HI0706 Haemophilus influenzae Rd KW20 lipoprotein NP_438864.1 749811 D 71421 CDS NP_438865.1 16272647 949732 751161..753746 1 NC_000907.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 753746 mutS 949732 mutS Haemophilus influenzae Rd KW20 DNA mismatch repair protein MutS NP_438865.1 751161 D 71421 CDS NP_438866.1 16272648 950262 753952..755337 1 NC_000907.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 755337 selA 950262 selA Haemophilus influenzae Rd KW20 selenocysteine synthase NP_438866.1 753952 D 71421 CDS NP_438867.1 16272649 950261 755334..757193 1 NC_000907.1 similar to SP:P14081 GB:X16644 PID:42937 PID:466728 GB:U00096; selenocysteine-specific elongation factor 757193 selB 950261 selB Haemophilus influenzae Rd KW20 selenocysteine-specific elongation factor NP_438867.1 755334 D 71421 CDS NP_438868.1 16272650 950711 757421..757717 1 NC_000907.1 hypothetical protein 757717 950711 HI0710 Haemophilus influenzae Rd KW20 hypothetical protein NP_438868.1 757421 D 71421 CDS NP_438869.1 16272651 949734 757717..758025 1 NC_000907.1 similar to PID:984581 GB:U00096 SP:Q47149 PID:1786419; hypothetical protein 758025 949734 HI0711 Haemophilus influenzae Rd KW20 hypothetical protein NP_438869.1 757717 D 71421 CDS NP_438870.1 16272652 949735 complement(758082..761336) 1 NC_000907.1 similar to PID:1000292 PID:984513; hemoglobin-binding protein 761336 949735 HI0712 Haemophilus influenzae Rd KW20 hemoglobin-binding protein NP_438870.1 758082 R 71421 CDS NP_438871.1 16272653 949736 761637..762935 1 NC_000907.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 762935 tig 949736 tig Haemophilus influenzae Rd KW20 trigger factor NP_438871.1 761637 D 71421 CDS NP_438872.3 161350016 949737 763058..763639 1 NC_000907.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 763639 clpP 949737 clpP Haemophilus influenzae Rd KW20 ATP-dependent Clp protease proteolytic subunit NP_438872.3 763058 D 71421 CDS NP_438873.1 16272655 949862 763649..764884 1 NC_000907.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 764884 clpX 949862 clpX Haemophilus influenzae Rd KW20 ATP-dependent protease ATP-binding subunit ClpX NP_438873.1 763649 D 71421 CDS NP_438874.1 16272656 949943 765122..765442 1 NC_000907.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 765442 secE 949943 secE Haemophilus influenzae Rd KW20 preprotein translocase subunit SecE NP_438874.1 765122 D 71421 CDS NP_438875.1 16272657 950637 765444..766001 1 NC_000907.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 766001 nusG 950637 nusG Haemophilus influenzae Rd KW20 transcription antitermination protein NusG NP_438875.1 765444 D 71421 CDS NP_438876.1 16272658 949738 766152..766904 1 NC_000907.1 similar to SP:P43262 PID:904221; lipoprotein 766904 vacJ 949738 vacJ Haemophilus influenzae Rd KW20 lipoprotein NP_438876.1 766152 D 71421 CDS NP_438877.1 16272659 949739 766958..767350 1 NC_000907.1 unknown function; forms homotrimers; binds small molecules of alpha-keto acids or alpha,beta-unsaturated acids; similar to GB:U14003 SP:P39330 PID:537085 GB:U00096 PID:1790691; hypothetical protein 767350 949739 HI0719 Haemophilus influenzae Rd KW20 hypothetical protein NP_438877.1 766958 D 71421 CDS NP_438878.1 16272660 949740 767518..768369 1 NC_000907.1 metalloprotease; heat shock protein HtpX 768369 htpX 949740 htpX Haemophilus influenzae Rd KW20 heat shock protein HtpX NP_438878.1 767518 D 71421 CDS NP_438879.2 30995395 949741 complement(768411..768650) 1 NC_000907.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 768650 949741 HI0721 Haemophilus influenzae Rd KW20 sulfur transfer protein SirA NP_438879.2 768411 R 71421 CDS NP_438880.2 30995396 949742 768754..769386 1 NC_000907.1 similar to GB:U00096 PID:1790283; hypothetical protein 769386 949742 HI0722 Haemophilus influenzae Rd KW20 hypothetical protein NP_438880.2 768754 D 71421 CDS NP_438881.1 16272663 949570 769389..770852 1 NC_000907.1 similar to GB:M87049 SP:P21166 PID:148249 PID:42359 PID:2367317; Trk system potassium uptake protein TrkH 770852 trkH 949570 trkH Haemophilus influenzae Rd KW20 Trk system potassium uptake protein TrkH NP_438881.1 769389 D 71421 CDS NP_438882.1 16272664 949751 776909..777469 1 NC_000907.1 similar to PID:1685095; hypothetical protein 777469 949751 HI0724 Haemophilus influenzae Rd KW20 hypothetical protein NP_438882.1 776909 D 71421 CDS NP_438883.1 16272665 949753 777473..777913 1 NC_000907.1 similar to PID:1685094; hypothetical protein 777913 949753 HI0725 Haemophilus influenzae Rd KW20 hypothetical protein NP_438883.1 777473 D 71421 CDS NP_438884.1 16272666 949754 complement(777975..778601) 1 NC_000907.1 similar to GB:U00008 SP:P31802 GB:L11273 PID:304917 PID:405947; nitrate/nitrite response regulator protein 778601 narP 949754 narP Haemophilus influenzae Rd KW20 nitrate/nitrite response regulator protein NP_438884.1 777975 R 71421 CDS NP_438885.1 16272667 949755 complement(778807..780054) 1 NC_000907.1 similar to SP:P19572; diaminopimelate decarboxylase 780054 lysA 949755 lysA Haemophilus influenzae Rd KW20 diaminopimelate decarboxylase NP_438885.1 778807 R 71421 CDS NP_438886.1 16272668 949756 780315..780620 1 NC_000907.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 780620 cyaY 949756 cyaY Haemophilus influenzae Rd KW20 frataxin-like protein NP_438886.1 780315 D 71421 CDS NP_438887.1 16272669 949757 780622..782481 1 NC_000907.1 similar to GB:M87049 SP:P15043 GB:M30198 PID:147559 PID:148221; ATP-dependent DNA helicase 782481 recQ 949757 recQ Haemophilus influenzae Rd KW20 ATP-dependent DNA helicase NP_438887.1 780622 D 71421 CDS NP_438888.1 16272670 949758 782566..784284 1 NC_000907.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 784284 proS 949758 proS Haemophilus influenzae Rd KW20 prolyl-tRNA synthetase NP_438888.1 782566 D 71421 CDS NP_438889.1 16272671 949761 complement(784372..786720) 1 NC_000907.1 determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein 786720 949761 HI0730 Haemophilus influenzae Rd KW20 organic solvent tolerance protein NP_438889.1 784372 R 71421 CDS NP_438893.1 16272675 950749 complement(788247..788969) 1 NC_000907.1 similar to GB:M63491 SP:P26647 PID:147298 PID:882548 GB:U00096; 1-acylglycerol-3-phosphate O-acyltransferase 788969 plsC 950749 plsC Haemophilus influenzae Rd KW20 1-acylglycerol-3-phosphate O-acyltransferase NP_438893.1 788247 R 71421 CDS NP_438894.1 16272676 950740 789055..789768 1 NC_000907.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 789768 950740 HI0735 Haemophilus influenzae Rd KW20 UDP-2,3-diacylglucosamine hydrolase NP_438894.1 789055 D 71421 CDS NP_438895.1 16272677 949764 complement(789998..791524) 1 NC_000907.1 similar to GB:AE000782; sodium-dependent transporter 791524 949764 HI0736 Haemophilus influenzae Rd KW20 sodium-dependent transporter NP_438895.1 789998 R 71421 CDS NP_438896.1 16272678 949765 791772..792569 1 NC_000907.1 similar to GB:M10313 SP:P00892 GB:M32253 GB:V00290 GB:X04890; acetohydroxy acid synthase II 792569 949765 HI0737 Haemophilus influenzae Rd KW20 acetohydroxy acid synthase II NP_438896.1 791772 D 71421 CDS NP_438897.1 16272679 949825 792641..794479 1 NC_000907.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 794479 ilvD 949825 ilvD Haemophilus influenzae Rd KW20 dihydroxy-acid dehydratase NP_438897.1 792641 D 71421 CDS NP_438898.1 16272680 950764 794559..796100 1 NC_000907.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 796100 ilvA 950764 ilvA Haemophilus influenzae Rd KW20 threonine dehydratase NP_438898.1 794559 D 71421 CDS NP_438899.1 16272681 949766 complement(796139..799618) 1 NC_000907.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 799618 dnaE 949766 dnaE Haemophilus influenzae Rd KW20 DNA polymerase III subunit alpha NP_438899.1 796139 R 71421 CDS NP_438900.2 30995397 949768 799857..801509 1 NC_000907.1 similar to GB:M34393 SP:P18159 PID:142994 PID:2226139 GB:AL009126; phosphomannomutase 801509 yhxB 949768 yhxB Haemophilus influenzae Rd KW20 phosphomannomutase NP_438900.2 799857 D 71421 CDS NP_438901.1 16272683 949769 801658..801987 1 NC_000907.1 hypothetical protein 801987 949769 HI0742 Haemophilus influenzae Rd KW20 hypothetical protein NP_438901.1 801658 D 71421 CDS NP_438902.1 16272684 949770 complement(802054..802563) 1 NC_000907.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 802563 secB 949770 secB Haemophilus influenzae Rd KW20 preprotein translocase subunit SecB NP_438902.1 802054 R 71421 CDS NP_438903.1 16272685 949771 complement(802577..803023) 1 NC_000907.1 similar to SP:P37688 PID:466749 GB:U00096 PID:1790040; hypothetical protein 803023 949771 HI0744 Haemophilus influenzae Rd KW20 hypothetical protein NP_438903.1 802577 R 71421 CDS NP_438904.1 16272686 949675 803249..804298 1 NC_000907.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II 804298 ansB 949675 ansB Haemophilus influenzae Rd KW20 L-asparaginase II NP_438904.1 803249 D 71421 CDS NP_438905.1 16272687 950696 804454..805776 1 NC_000907.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 805776 dcuB 950696 dcuB Haemophilus influenzae Rd KW20 anaerobic C4-dicarboxylate transporter NP_438905.1 804454 D 71421 CDS NP_438906.1 16272688 949772 805980..807314 1 NC_000907.1 similar to SP:P00393 PID:581140 GB:U00096 PID:1651546 PID:1787352; NADH dehydrogenase 807314 ndh 949772 ndh Haemophilus influenzae Rd KW20 NADH dehydrogenase NP_438906.1 805980 D 71421 CDS NP_438907.1 16272689 949773 complement(807394..809826) 1 NC_000907.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 809826 949773 HI0748 Haemophilus influenzae Rd KW20 glycerol-3-phosphate acyltransferase NP_438907.1 807394 R 71421 CDS NP_438908.2 30995398 949794 810081..810704 1 NC_000907.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 810704 lexA 949794 lexA Haemophilus influenzae Rd KW20 LexA repressor NP_438908.2 810081 D 71421 CDS NP_438909.1 16272691 949560 810848..811672 1 NC_000907.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 811672 dapF 949560 dapF Haemophilus influenzae Rd KW20 diaminopimelate epimerase NP_438909.1 810848 D 71421 CDS NP_438910.1 16272692 949774 complement(811891..812388) 1 NC_000907.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 812388 tpx 949774 tpx Haemophilus influenzae Rd KW20 thiol peroxidase NP_438910.1 811891 R 71421 CDS NP_438911.1 16272693 949775 812967..816929 1 NC_000907.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 816929 purL 949775 purL Haemophilus influenzae Rd KW20 phosphoribosylformylglycinamidine synthase NP_438911.1 812967 D 71421 CDS NP_438912.1 16272694 949467 817101..818249 1 NC_000907.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 818249 anmK 949467 anmK Haemophilus influenzae Rd KW20 anhydro-N-acetylmuramic acid kinase NP_438912.1 817101 D 71421 CDS NP_438913.1 16272695 949804 818259..819170 1 NC_000907.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid-6-phosphate etherase 819170 murQ 949804 murQ Haemophilus influenzae Rd KW20 N-acetylmuramic acid-6-phosphate etherase NP_438913.1 818259 D 71421 CDS NP_438914.2 30995399 949515 complement(819200..820042) 1 NC_000907.1 similar to SP:P37691 PID:912478 GB:U00096 PID:1790043; hypothetical protein 820042 dat1 949515 dat1 Haemophilus influenzae Rd KW20 hypothetical protein NP_438914.2 819200 R 71421 CDS NP_438915.1 16272697 950697 complement(820042..821274) 1 NC_000907.1 similar to SP:P37690 PID:466751 GB:U00096 PID:1790042; hypothetical protein 821274 950697 HI0756 Haemophilus influenzae Rd KW20 hypothetical protein NP_438915.1 820042 R 71421 CDS NP_438916.1 16272698 949776 821450..822133 1 NC_000907.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 822133 gpmA 949776 gpmA Haemophilus influenzae Rd KW20 phosphoglyceromutase NP_438916.1 821450 D 71421 CDS NP_438917.1 16272699 950704 complement(822211..822423) 1 NC_000907.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 822423 rpmE 950704 rpmE Haemophilus influenzae Rd KW20 50S ribosomal protein L31 NP_438917.1 822211 R 71421 CDS NP_438918.1 16272700 950824 822600..823736 1 NC_000907.1 similar to GB:M59471 SP:P17802 GB:X52391 PID:146864 PID:42073; A/G-specific adenine glycosylase 823736 mutY 950824 mutY Haemophilus influenzae Rd KW20 A/G-specific adenine glycosylase NP_438918.1 822600 D 71421 CDS NP_438919.1 16272701 949979 823714..823986 1 NC_000907.1 similar to PID:882491 SP:P52065 GB:U00096 PID:1789332; hypothetical protein 823986 949979 HI0760 Haemophilus influenzae Rd KW20 hypothetical protein NP_438919.1 823714 D 71421 CDS NP_438920.1 16272702 950821 824001..825074 1 NC_000907.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 825074 mltC 950821 mltC Haemophilus influenzae Rd KW20 murein transglycosylase C NP_438920.1 824001 D 71421 CDS NP_438921.1 16272703 949781 complement(825685..826365) 1 NC_000907.1 hypothetical protein 826365 949781 HI0762 Haemophilus influenzae Rd KW20 hypothetical protein NP_438921.1 825685 R 71421 CDS NP_438922.1 16272704 950800 complement(826362..827627) 1 NC_000907.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 827627 nadR 950800 nadR Haemophilus influenzae Rd KW20 nicotinamide-nucleotide adenylyltransferase NP_438922.1 826362 R 71421 CDS NP_438923.1 16272705 950808 827846..828493 1 NC_000907.1 DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase 828493 ribB 950808 ribB Haemophilus influenzae Rd KW20 3,4-dihydroxy-2-butanone 4-phosphate synthase NP_438923.1 827846 D 71421 CDS NP_438924.2 30995400 950810 828520..829356 1 NC_000907.1 similar to GB:M37913 GB:L19441 PID:1573535; lipooligosaccharide biosynthesis protein 829356 950810 HI0765 Haemophilus influenzae Rd KW20 lipooligosaccharide biosynthesis protein NP_438924.2 828520 D 71421 CDS NP_438925.1 16272707 949782 complement(829405..829887) 1 NC_000907.1 YibK; binds cofactor S-adenosylhomocysteine; similar to SP:P33899 PID:466744 GB:U00096 PID:1790034; RNA methyltransferase 829887 yibK 949782 yibK Haemophilus influenzae Rd KW20 RNA methyltransferase NP_438925.1 829405 R 71421 CDS NP_438926.1 16272708 949786 complement(829898..830479) 1 NC_000907.1 similar to SP:P10120 GB:U00039 GB:X04398 PID:41497 PID:466601; hypothetical protein 830479 949786 HI0767 Haemophilus influenzae Rd KW20 hypothetical protein NP_438926.1 829898 R 71421 CDS NP_438927.1 16272709 950144 830534..831778 1 NC_000907.1 similar to SP:P10121 GB:U00039 GB:X04398 PID:41498 PID:466600; cell division protein FtsY 831778 ftsY 950144 ftsY Haemophilus influenzae Rd KW20 cell division protein FtsY NP_438927.1 830534 D 71421 CDS NP_438928.1 16272710 950167 831797..832453 1 NC_000907.1 similar to SP:P10115 GB:U00039 GB:X04398 PID:41499 PID:466599; cell division ATP-binding protein 832453 ftsE 950167 ftsE Haemophilus influenzae Rd KW20 cell division ATP-binding protein NP_438928.1 831797 D 71421 CDS NP_438929.1 16272711 949837 832463..833395 1 NC_000907.1 ABC transporter, membrane protein; cell division protein FtsX 833395 ftsX 949837 ftsX Haemophilus influenzae Rd KW20 cell division protein FtsX NP_438929.1 832463 D 71421 CDS NP_438930.1 16272712 950638 complement(833490..834671) 1 NC_000907.1 similar to GB:U00096 SP:P76461 PID:1736879 PID:1788554 PID:1799573; acetyl-CoA acetyltransferase 834671 atoB 950638 atoB Haemophilus influenzae Rd KW20 acetyl-CoA acetyltransferase NP_438930.1 833490 R 71421 CDS NP_438931.1 16272713 949788 complement(834686..836029) 1 NC_000907.1 similar to GB:U00096 SP:P76460 PID:1788553; short chain fatty acids transporter 836029 atoE 949788 atoE Haemophilus influenzae Rd KW20 short chain fatty acids transporter NP_438931.1 834686 R 71421 CDS NP_438932.1 16272714 949789 complement(836026..836697) 1 NC_000907.1 similar to GB:U00096 SP:P76459 PID:1736877 PID:1788552; acetate CoA-transferase subunit beta 836697 atoA 949789 atoA Haemophilus influenzae Rd KW20 acetate CoA-transferase subunit beta NP_438932.1 836026 R 71421 CDS NP_438933.1 16272715 949792 complement(836708..837361) 1 NC_000907.1 similar to GB:U00096 SP:P76458 PID:1736876 PID:1788551; acetyl-CoA:acetoacetyl-CoA transferase subunit alpha 837361 949792 HI0774 Haemophilus influenzae Rd KW20 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha NP_438933.1 836708 R 71421 CDS NP_438934.2 30995401 950670 837609..838514 1 NC_000907.1 similar to GB:X73124 SP:P39592 PID:413948 GB:AL009126; transcriptional regulator 838514 950670 HI0775 Haemophilus influenzae Rd KW20 transcriptional regulator NP_438934.2 837609 D 71421 CDS NP_438935.2 161350025 950681 838750..839061 1 NC_000907.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 839061 rpsJ 950681 rpsJ Haemophilus influenzae Rd KW20 30S ribosomal protein S10 NP_438935.2 838750 D 71421 CDS NP_438936.1 16272718 950820 839078..839704 1 NC_000907.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 839704 rplC 950820 rplC Haemophilus influenzae Rd KW20 50S ribosomal protein L3 NP_438936.1 839078 D 71421 CDS NP_438937.1 16272719 950806 839720..840322 1 NC_000907.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 840322 rplD 950806 rplD Haemophilus influenzae Rd KW20 50S ribosomal protein L4 NP_438937.1 839720 D 71421 CDS NP_438938.1 16272720 949793 840319..840618 1 NC_000907.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 840618 rplW 949793 rplW Haemophilus influenzae Rd KW20 50S ribosomal protein L23 NP_438938.1 840319 D 71421 CDS NP_438939.1 16272721 949796 840636..841457 1 NC_000907.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 841457 rplB 949796 rplB Haemophilus influenzae Rd KW20 50S ribosomal protein L2 NP_438939.1 840636 D 71421 CDS NP_438940.1 16272722 949797 841483..841758 1 NC_000907.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 841758 rpsS 949797 rpsS Haemophilus influenzae Rd KW20 30S ribosomal protein S19 NP_438940.1 841483 D 71421 CDS NP_438941.1 16272723 949798 841770..842102 1 NC_000907.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 842102 rplV 949798 rplV Haemophilus influenzae Rd KW20 50S ribosomal protein L22 NP_438941.1 841770 D 71421 CDS NP_438942.1 16272724 949799 842120..842827 1 NC_000907.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 842827 rpsC 949799 rpsC Haemophilus influenzae Rd KW20 30S ribosomal protein S3 NP_438942.1 842120 D 71421 CDS NP_438943.1 16272725 950752 842841..843251 1 NC_000907.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 843251 rplP 950752 rplP Haemophilus influenzae Rd KW20 50S ribosomal protein L16 NP_438943.1 842841 D 71421 CDS NP_438944.1 16272726 950743 843251..843442 1 NC_000907.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 843442 rpmC 950743 rpmC Haemophilus influenzae Rd KW20 50S ribosomal protein L29 NP_438944.1 843251 D 71421 CDS NP_438945.1 16272727 949800 843442..843699 1 NC_000907.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 843699 rpsQ 949800 rpsQ Haemophilus influenzae Rd KW20 30S ribosomal protein S17 NP_438945.1 843442 D 71421 CDS NP_438946.1 16272728 949801 844090..844695 1 NC_000907.1 hypothetical protein 844695 949801 HI0787 Haemophilus influenzae Rd KW20 hypothetical protein NP_438946.1 844090 D 71421 CDS NP_438947.1 16272729 949802 844976..845347 1 NC_000907.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 845347 rplN 949802 rplN Haemophilus influenzae Rd KW20 50S ribosomal protein L14 NP_438947.1 844976 D 71421 CDS NP_438948.1 16272730 949805 845358..845669 1 NC_000907.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 845669 rplX 949805 rplX Haemophilus influenzae Rd KW20 50S ribosomal protein L24 NP_438948.1 845358 D 71421 CDS NP_438949.3 542123255 949806 845687..846226 1 NC_000907.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 846226 rplE 949806 rplE Haemophilus influenzae Rd KW20 50S ribosomal protein L5 NP_438949.3 845687 D 71421 CDS NP_438950.1 16272732 949808 846238..846543 1 NC_000907.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 846543 rpsN 949808 rpsN Haemophilus influenzae Rd KW20 30S ribosomal protein S14 NP_438950.1 846238 D 71421 CDS NP_438951.1 16272733 949811 846580..846972 1 NC_000907.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 846972 rpsH 949811 rpsH Haemophilus influenzae Rd KW20 30S ribosomal protein S8 NP_438951.1 846580 D 71421 CDS NP_438952.1 16272734 950560 846988..847521 1 NC_000907.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 847521 rplF 950560 rplF Haemophilus influenzae Rd KW20 50S ribosomal protein L6 NP_438952.1 846988 D 71421 CDS NP_438953.1 16272735 950639 847535..847888 1 NC_000907.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 847888 rplR 950639 rplR Haemophilus influenzae Rd KW20 50S ribosomal protein L18 NP_438953.1 847535 D 71421 CDS NP_438954.1 16272736 949813 847903..848403 1 NC_000907.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 848403 rpsE 949813 rpsE Haemophilus influenzae Rd KW20 30S ribosomal protein S5 NP_438954.1 847903 D 71421 CDS NP_438955.1 16272737 949787 848410..848589 1 NC_000907.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 848589 rpmD 949787 rpmD Haemophilus influenzae Rd KW20 50S ribosomal protein L30 NP_438955.1 848410 D 71421 CDS NP_438956.1 16272738 949815 848593..849027 1 NC_000907.1 late assembly protein; 50S ribosomal protein L15 849027 rplO 949815 rplO Haemophilus influenzae Rd KW20 50S ribosomal protein L15 NP_438956.1 848593 D 71421 CDS NP_438957.1 16272739 949574 849035..850360 1 NC_000907.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 850360 secY 949574 secY Haemophilus influenzae Rd KW20 preprotein translocase subunit SecY NP_438957.1 849035 D 71421 CDS NP_438958.1 16272740 949814 850389..850502 1 NC_000907.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 850502 rpmJ 949814 rpmJ Haemophilus influenzae Rd KW20 50S ribosomal protein L36 NP_438958.1 850389 D 71421 CDS NP_438959.3 542123257 949817 850642..851010 1 NC_000907.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 851010 rpsM 949817 rpsM Haemophilus influenzae Rd KW20 30S ribosomal protein S13 NP_438959.3 850642 D 71421 CDS NP_438960.1 16272742 949749 851013..851402 1 NC_000907.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 851402 rpS11 949749 rpS11 Haemophilus influenzae Rd KW20 30S ribosomal protein S11 NP_438960.1 851013 D 71421 CDS NP_438961.1 16272743 950601 851430..852050 1 NC_000907.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 852050 rpsD 950601 rpsD Haemophilus influenzae Rd KW20 30S ribosomal protein S4 NP_438961.1 851430 D 71421 CDS NP_438962.1 16272744 949818 852082..853068 1 NC_000907.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 853068 rpoA 949818 rpoA Haemophilus influenzae Rd KW20 DNA-directed RNA polymerase subunit alpha NP_438962.1 852082 D 71421 CDS NP_438963.1 16272745 949819 853109..853495 1 NC_000907.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 853495 rplQ 949819 rplQ Haemophilus influenzae Rd KW20 50S ribosomal protein L17 NP_438963.1 853109 D 71421 CDS NP_438966.1 16272747 949820 855169..855975 1 NC_000907.1 similar to GB:L77117 SP:Q57883 PID:1591145; hypothetical protein 855975 949820 HI0806 Haemophilus influenzae Rd KW20 hypothetical protein NP_438966.1 855169 D 71421 CDS NP_438967.1 16272748 949821 complement(856007..857200) 1 NC_000907.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 857200 949821 HI0807 Haemophilus influenzae Rd KW20 1-deoxy-D-xylulose 5-phosphate reductoisomerase NP_438967.1 856007 R 71421 CDS NP_438968.1 16272749 949822 complement(857310..857867) 1 NC_000907.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 857867 frr 949822 frr Haemophilus influenzae Rd KW20 ribosome recycling factor NP_438968.1 857310 R 71421 CDS NP_438969.1 16272750 950742 complement(858019..859635) 1 NC_000907.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 859635 pckA 950742 pckA Haemophilus influenzae Rd KW20 phosphoenolpyruvate carboxykinase NP_438969.1 858019 R 71421 CDS NP_438970.1 16272751 950307 complement(859808..860689) 1 NC_000907.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 860689 hslO 950307 hslO Haemophilus influenzae Rd KW20 Hsp33-like chaperonin NP_438970.1 859808 R 71421 CDS NP_438971.1 16272752 949824 complement(860834..862207) 1 NC_000907.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 862207 argH 949824 argH Haemophilus influenzae Rd KW20 argininosuccinate lyase NP_438971.1 860834 R 71421 CDS NP_438972.1 16272753 949826 complement(862342..863229) 1 NC_000907.1 similar to GB:M98830 SP:P25520 GB:X59940 PID:146073 PID:42026; glucosephosphate uridylyltransferase 863229 galU 949826 galU Haemophilus influenzae Rd KW20 glucosephosphate uridylyltransferase NP_438972.1 862342 R 71421 CDS NP_438973.1 16272754 949827 complement(863251..863442) 1 NC_000907.1 affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator 863442 csrA 949827 csrA Haemophilus influenzae Rd KW20 carbon storage regulator NP_438973.1 863251 R 71421 CDS NP_438974.1 16272755 950776 complement(863520..866144) 1 NC_000907.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 866144 alaS 950776 alaS Haemophilus influenzae Rd KW20 alanyl-tRNA synthetase NP_438974.1 863520 R 71421 CDS NP_438975.1 16272756 949495 complement(866332..866757) 1 NC_000907.1 forms asymmetric homodimer; similar to GB:U00039 SP:P28242 GB:X67639 PID:43280 PID:466632; universal stress protein A 866757 uspA 949495 uspA Haemophilus influenzae Rd KW20 universal stress protein A NP_438975.1 866332 R 71421 CDS NP_438976.1 16272757 949828 complement(866859..868151) 1 NC_000907.1 similar to GB:D00398 SP:P15034 PID:216529 PID:216627 PID:882438; aminopeptidase P 868151 pepP 949828 pepP Haemophilus influenzae Rd KW20 aminopeptidase P NP_438976.1 866859 R 71421 CDS NP_438977.1 16272758 949830 complement(868163..868711) 1 NC_000907.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein 868711 949830 HI0817 Haemophilus influenzae Rd KW20 hypothetical protein NP_438977.1 868163 R 71421 CDS NP_438978.1 16272759 949661 complement(868882..869904) 1 NC_000907.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase 869904 galM 949661 galM Haemophilus influenzae Rd KW20 aldose 1-epimerase NP_438978.1 868882 R 71421 CDS NP_438979.2 30995403 950587 complement(869914..871068) 1 NC_000907.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 871068 galK 950587 galK Haemophilus influenzae Rd KW20 galactokinase NP_438979.2 869914 R 71421 CDS NP_438980.1 16272761 950798 complement(871145..872194) 1 NC_000907.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 872194 galT 950798 galT Haemophilus influenzae Rd KW20 galactose-1-phosphate uridylyltransferase NP_438980.1 871145 R 71421 CDS NP_438981.1 16272762 949832 872402..873400 1 NC_000907.1 similar to SP:P31766 GB:X65934 PID:1573834; LacI family transcriptional repressor 873400 galR 949832 galR Haemophilus influenzae Rd KW20 LacI family transcriptional repressor NP_438981.1 872402 D 71421 CDS NP_438982.2 30995404 949834 873545..874540 1 NC_000907.1 similar to SP:P02927 GB:K00419 GB:X05646 PID:146853 PID:146857; galactose ABC transporter substrate-binding protein 874540 mglB 949834 mglB Haemophilus influenzae Rd KW20 galactose ABC transporter substrate-binding protein NP_438982.2 873545 D 71421 CDS NP_438983.1 16272764 949835 874606..876126 1 NC_000907.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein 876126 mglA 949835 mglA Haemophilus influenzae Rd KW20 galactose/methyl galaxtoside transporter ATP-binding protein NP_438983.1 874606 D 71421 CDS NP_438984.1 16272765 949838 876143..877153 1 NC_000907.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane protein 877153 mglC 949838 mglC Haemophilus influenzae Rd KW20 beta-methylgalactoside transporter inner membrane protein NP_438984.1 876143 D 71421 CDS NP_438985.1 16272766 949928 877299..878033 1 NC_000907.1 hypothetical protein 878033 949928 HI0825 Haemophilus influenzae Rd KW20 hypothetical protein NP_438985.1 877299 D 71421 CDS NP_438986.1 16272767 949918 878039..878596 1 NC_000907.1 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 878596 949918 HI0826 Haemophilus influenzae Rd KW20 intracellular septation protein A NP_438986.1 878039 D 71421 CDS NP_438987.1 16272768 949716 878596..879060 1 NC_000907.1 similar to GB:K00431 SP:P04379 PID:455187 PID:902382 PID:902391; hypothetical protein 879060 949716 HI0827 Haemophilus influenzae Rd KW20 hypothetical protein NP_438987.1 878596 D 71421 CDS NP_438988.1 16272769 949842 879077..879373 1 NC_000907.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; YciI-like protein 879373 949842 HI0828 Haemophilus influenzae Rd KW20 YciI-like protein NP_438988.1 879077 D 71421 CDS NP_438989.1 16272770 949843 879389..881170 1 NC_000907.1 similar to GB:U14003 SP:P03810 GB:M69185 PID:147836 PID:537232; soluble lytic murein transglycosylase 881170 949843 HI0829 Haemophilus influenzae Rd KW20 soluble lytic murein transglycosylase NP_438989.1 879389 D 71421 CDS NP_438990.1 16272771 949844 881208..881513 1 NC_000907.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 881513 trpR 949844 trpR Haemophilus influenzae Rd KW20 Trp operon repressor NP_438990.1 881208 D 71421 CDS NP_438991.2 30995405 949845 881500..882240 1 NC_000907.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase 882240 mtgA 949845 mtgA Haemophilus influenzae Rd KW20 monofunctional biosynthetic peptidoglycan transglycosylase NP_438991.2 881500 D 71421 CDS NP_438992.1 16272773 949846 complement(882346..882690) 1 NC_000907.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 882690 frdD 949846 frdD Haemophilus influenzae Rd KW20 fumarate reductase subunit D NP_438992.1 882346 R 71421 CDS NP_438993.2 228918116 949847 complement(882703..883113) 1 NC_000907.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C 883113 frdC 949847 frdC Haemophilus influenzae Rd KW20 fumarate reductase subunit C NP_438993.2 882703 R 71421 CDS NP_438994.1 16272775 949848 complement(883124..883894) 1 NC_000907.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit 883894 frdB 949848 frdB Haemophilus influenzae Rd KW20 fumarate reductase iron-sulfur subunit NP_438994.1 883124 R 71421 CDS NP_438995.1 16272776 949849 complement(883887..885686) 1 NC_000907.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 885686 frdA 949849 frdA Haemophilus influenzae Rd KW20 fumarate reductase flavoprotein subunit NP_438995.1 883887 R 71421 CDS NP_438996.2 161350024 949850 885898..886869 1 NC_000907.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 886869 genX 949850 genX Haemophilus influenzae Rd KW20 lysyl-tRNA synthetase NP_438996.2 885898 D 71421 CDS NP_438997.1 16272778 949851 complement(887135..887818) 1 NC_000907.1 similar to GB:L19201 SP:P16244 GB:L14579 GB:X13307 PID:145589; response regulator 887818 cpxR 949851 cpxR Haemophilus influenzae Rd KW20 response regulator NP_438997.1 887135 R 71421 CDS NP_438998.2 542123256 949852 complement(887872..888285) 1 NC_000907.1 similar to SP:P23089; small protein A 888285 949852 HI0838 Haemophilus influenzae Rd KW20 small protein A NP_438998.2 887872 R 71421 CDS NP_438999.2 30995406 949853 complement(888351..889367) 1 NC_000907.1 similar to SP:P33920 PID:405914 GB:U00096 PID:1788513; nucleoid-associated protein NdpA 889367 949853 HI0839 Haemophilus influenzae Rd KW20 nucleoid-associated protein NdpA NP_438999.2 888351 R 71421 CDS NP_439000.1 16272781 949854 889493..889711 1 NC_000907.1 similar to SP:P33921 PID:405915 GB:U00096 PID:1788514; hypothetical protein 889711 949854 HI0840 Haemophilus influenzae Rd KW20 hypothetical protein NP_439000.1 889493 D 71421 CDS NP_439001.1 16272782 949855 889713..891470 1 NC_000907.1 similar to SP:P33922 PID:453987 GB:U00096 PID:1788515; hypothetical protein 891470 949855 HI0841 Haemophilus influenzae Rd KW20 hypothetical protein NP_439001.1 889713 D 71421 CDS NP_439004.1 16272785 950590 complement(892798..893376) 1 NC_000907.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA 893376 mobA 950590 mobA Haemophilus influenzae Rd KW20 molybdopterin-guanine dinucleotide biosynthesis protein MobA NP_439004.1 892798 R 71421 CDS NP_439005.1 16272786 950597 893463..893729 1 NC_000907.1 similar to GB:L19201 SP:P32126 PID:304964 GB:U00096 PID:1790289; hypothetical protein 893729 950597 HI0845 Haemophilus influenzae Rd KW20 hypothetical protein NP_439005.1 893463 D 71421 CDS NP_439006.1 16272787 949506 893740..894357 1 NC_000907.1 similar to GB:M94205 SP:P31810 PID:1573860; oxidoreductase 894357 por 949506 por Haemophilus influenzae Rd KW20 oxidoreductase NP_439006.1 893740 D 71421 CDS NP_439007.1 16272788 950632 894419..894754 1 NC_000907.1 similar to GB:M87049 SP:P27827 PID:148172 GB:U00096 PID:2367277; hypothetical protein 894754 950632 HI0847 Haemophilus influenzae Rd KW20 hypothetical protein NP_439007.1 894419 D 71421 CDS NP_439008.1 16272789 949860 894898..895989 1 NC_000907.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 895989 trmA 949860 trmA Haemophilus influenzae Rd KW20 tRNA (uracil-5-)-methyltransferase NP_439008.1 894898 D 71421 CDS NP_439009.1 16273637 949861 895971..896744 1 NC_000907.1 SAM-dependent methyltransferase 896744 949861 HI0849m Haemophilus influenzae Rd KW20 SAM-dependent methyltransferase NP_439009.1 895971 D 71421 CDS NP_439010.1 16272790 949863 896738..897172 1 NC_000907.1 similar to SP:P46187 PID:987645 PID:1045631 PID:1050877 GB:U00096; sigma-E factor regulatory protein 897172 949863 HI0850 Haemophilus influenzae Rd KW20 sigma-E factor regulatory protein NP_439010.1 896738 D 71421 CDS NP_439011.1 16272791 949864 897574..898110 1 NC_000907.1 similar to GB:L19201 SP:P32125 PID:304962 GB:U00096 PID:1790287; molybdopterin-guanine dinucleotide biosynthesis protein B 898110 mobB 949864 mobB Haemophilus influenzae Rd KW20 molybdopterin-guanine dinucleotide biosynthesis protein B NP_439011.1 897574 D 71421 CDS NP_439012.1 16272792 949865 898107..899498 1 NC_000907.1 similar to GB:L10328 SP:P31474 PID:290604 GB:U00096 PID:1790195; hypothetical protein 899498 949865 HI0852 Haemophilus influenzae Rd KW20 hypothetical protein NP_439012.1 898107 D 71421 CDS NP_439013.1 16272793 949866 899639..901288 1 NC_000907.1 similar to GB:M84028 SP:P33950 PID:1573869; heme-binding lipoprotein 901288 dppA 949866 dppA Haemophilus influenzae Rd KW20 heme-binding lipoprotein NP_439013.1 899639 D 71421 CDS NP_439014.1 16272794 949867 901464..902225 1 NC_000907.1 similar to GB:AE000511 PID:2313418; heme iron utilization protein 902225 949867 HI0854 Haemophilus influenzae Rd KW20 heme iron utilization protein NP_439014.1 901464 D 71421 CDS NP_439015.1 16272795 949868 complement(902362..902709) 1 NC_000907.1 similar to SP:P42626 PID:606050 GB:U00096 PID:1789496; hypothetical protein 902709 949868 HI0855 Haemophilus influenzae Rd KW20 hypothetical protein NP_439015.1 902362 R 71421 CDS NP_439016.1 16272796 950729 complement(902724..905516) 1 NC_000907.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 905516 polA 950729 polA Haemophilus influenzae Rd KW20 DNA polymerase I NP_439016.1 902724 R 71421 CDS NP_439017.1 16272797 950666 905665..905967 1 NC_000907.1 similar to SP:P45580 PID:882440 GB:U00096 PID:1789277; hypothetical protein 905967 950666 HI0857 Haemophilus influenzae Rd KW20 hypothetical protein NP_439017.1 905665 D 71421 CDS NP_439018.1 16272798 949870 906285..906848 1 NC_000907.1 similar to GB:M12965 SP:P09160 PID:147874 PID:882441 GB:U00096; hypothetical protein 906848 949870 HI0858 Haemophilus influenzae Rd KW20 hypothetical protein NP_439018.1 906285 D 71421 CDS NP_439019.1 16272799 949871 906976..909546 1 NC_000907.1 similar to GB:M29364 SP:P03815 GB:V00350 GB:X57620 PID:1236633; ATP-dependent Clp protease ATPase subunit 909546 clpB 949871 clpB Haemophilus influenzae Rd KW20 ATP-dependent Clp protease ATPase subunit NP_439019.1 906976 D 71421 CDS NP_439020.1 16272800 949872 complement(909583..910323) 1 NC_000907.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 910323 949872 HI0860 Haemophilus influenzae Rd KW20 23S rRNA (guanosine-2'-O-)-methyltransferase NP_439020.1 909583 R 71421 CDS NP_439021.1 16272801 949873 complement(910379..912727) 1 NC_000907.1 exoribonuclease R; similar to GB:U14003 SP:P21499 PID:537020 GB:U00096 PID:1790622; virulence-associated protein 912727 vacB 949873 vacB Haemophilus influenzae Rd KW20 virulence-associated protein NP_439021.1 910379 R 71421 CDS NP_439022.1 16272802 949874 complement(912919..913626) 1 NC_000907.1 similar to SP:P37619 PID:466607 GB:U00096 PID:1789882; hypothetical protein 913626 949874 HI0862 Haemophilus influenzae Rd KW20 hypothetical protein NP_439022.1 912919 R 71421 CDS NP_439023.2 161350023 949875 913819..914451 1 NC_000907.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 914451 pdxH 949875 pdxH Haemophilus influenzae Rd KW20 pyridoxamine 5'-phosphate oxidase NP_439023.2 913819 D 71421 CDS NP_439024.1 16272804 949876 complement(914539..916389) 1 NC_000907.1 similar to GB:L19201 SP:P32132 PID:304976 GB:U00096 PID:1790302; GTP-binding protein 916389 949876 HI0864 Haemophilus influenzae Rd KW20 GTP-binding protein NP_439024.1 914539 R 71421 CDS NP_439025.1 16272805 949878 916620..918038 1 NC_000907.1 similar to SP:P28786 GB:X68129 PID:45900; glutamine synthetase 918038 glnA 949878 glnA Haemophilus influenzae Rd KW20 glutamine synthetase NP_439025.1 916620 D 71421 CDS NP_439026.1 16272806 950756 918515..919138 1 NC_000907.1 hypothetical protein 919138 950756 HI0866 Haemophilus influenzae Rd KW20 hypothetical protein NP_439026.1 918515 D 71421 CDS NP_439027.1 16272807 950724 919376..920590 1 NC_000907.1 similar to SP:P37781 PID:454902; lipopolysaccharide biosynthesis protein 920590 950724 HI0867 Haemophilus influenzae Rd KW20 lipopolysaccharide biosynthesis protein NP_439027.1 919376 D 71421 CDS NP_439028.1 16272808 949464 920571..921323 1 NC_000907.1 similar to GB:AL009126; hypothetical protein 921323 949464 HI0868 Haemophilus influenzae Rd KW20 hypothetical protein NP_439028.1 920571 D 71421 CDS NP_439032.1 16272812 949881 923293..924213 1 NC_000907.1 N-acetylneuraminic acid synthase-like protein 924213 siaA 949881 siaA Haemophilus influenzae Rd KW20 N-acetylneuraminic acid synthase-like protein NP_439032.1 923293 D 71421 CDS NP_439033.1 16272813 949841 924206..925621 1 NC_000907.1 similar to SP:P26406 GB:X52093 PID:1335815 PID:1335817; undecaprenyl-phosphate galactosephosphotransferase 925621 wbaP 949841 wbaP Haemophilus influenzae Rd KW20 undecaprenyl-phosphate galactosephosphotransferase NP_439033.1 924206 D 71421 CDS NP_439034.2 30995408 949510 925683..926696 1 NC_000907.1 similar to GB:M87049 SP:P27830 PID:148191 GB:U00096 PID:1790223; dTDP-glucose 46-dehydratase 926696 rffG 949510 rffG Haemophilus influenzae Rd KW20 dTDP-glucose 46-dehydratase NP_439034.2 925683 D 71421 CDS NP_439035.1 16272815 949882 complement(926749..927948) 1 NC_000907.1 hypothetical protein 927948 949882 HI0874 Haemophilus influenzae Rd KW20 hypothetical protein NP_439035.1 926749 R 71421 CDS NP_439037.1 16272816 949884 929409..929834 1 NC_000907.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 929834 ndk 949884 ndk Haemophilus influenzae Rd KW20 nucleoside diphosphate kinase NP_439037.1 929409 D 71421 CDS NP_439038.1 16272817 949885 complement(929904..931076) 1 NC_000907.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 931076 obgE 949885 obgE Haemophilus influenzae Rd KW20 GTPase ObgE NP_439038.1 929904 R 71421 CDS NP_439039.1 16272818 949421 complement(931104..932024) 1 NC_000907.1 similar to SP:P28636 PID:216638 PID:606122 GB:U00096 PID:1789575; hypothetical protein 932024 949421 HI0878 Haemophilus influenzae Rd KW20 hypothetical protein NP_439039.1 931104 R 71421 CDS NP_439040.1 16272819 950621 complement(932105..932362) 1 NC_000907.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 932362 rpmA 950621 rpmA Haemophilus influenzae Rd KW20 50S ribosomal protein L27 NP_439040.1 932105 R 71421 CDS NP_439041.1 16272820 950467 complement(932383..932694) 1 NC_000907.1 similar to GB:D13267 SP:P02422 PID:216636 PID:606124 GB:U00096; 50S ribosomal protein L21 932694 rplU 950467 rplU Haemophilus influenzae Rd KW20 50S ribosomal protein L21 NP_439041.1 932383 R 71421 CDS NP_439042.1 16272821 949563 932907..933896 1 NC_000907.1 similar to SP:P19641 GB:X68873 PID:388220 PID:606125 GB:U00096; octaprenyl-diphosphate synthase 933896 ispB 949563 ispB Haemophilus influenzae Rd KW20 octaprenyl-diphosphate synthase NP_439042.1 932907 D 71421 CDS NP_439043.1 16272822 949886 933947..934684 1 NC_000907.1 hypothetical protein 934684 949886 HI0882 Haemophilus influenzae Rd KW20 hypothetical protein NP_439043.1 933947 D 71421 CDS NP_439044.1 16272823 949887 complement(934743..936113) 1 NC_000907.1 similar to PID:757741 SP:Q45068 PID:1405464 GB:AL009126; Na+/alanine symporter 936113 949887 HI0883 Haemophilus influenzae Rd KW20 Na+/alanine symporter NP_439044.1 934743 R 71421 CDS NP_439045.1 16272824 949839 complement(936511..937221) 1 NC_000907.1 similar to SP:P03026 GB:L34010 GB:M10044 PID:1790863; two-component response regulator 937221 arcA 949839 arcA Haemophilus influenzae Rd KW20 two-component response regulator NP_439045.1 936511 R 71421 CDS NP_439046.1 16272825 950312 937413..939152 1 NC_000907.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein 939152 dipZ 950312 dipZ Haemophilus influenzae Rd KW20 thiol:disulfide interchange protein NP_439046.1 937413 D 71421 CDS NP_439047.1 16272826 949888 939264..939668 1 NC_000907.1 hypothetical protein 939668 949888 HI0886 Haemophilus influenzae Rd KW20 hypothetical protein NP_439047.1 939264 D 71421 CDS NP_439048.1 16272827 949891 939856..941454 1 NC_000907.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 941454 purH 949891 purH Haemophilus influenzae Rd KW20 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase NP_439048.1 939856 D 71421 CDS NP_439049.1 16272828 949893 941550..942839 1 NC_000907.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 942839 purD 949893 purD Haemophilus influenzae Rd KW20 phosphoribosylamine--glycine ligase NP_439049.1 941550 D 71421 CDS NP_439050.1 16272829 949894 942963..944228 1 NC_000907.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 944228 glyA 949894 glyA Haemophilus influenzae Rd KW20 serine hydroxymethyltransferase NP_439050.1 942963 D 71421 CDS NP_439051.1 16273638 950766 944299..944919 1 NC_000907.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 944919 coaE 950766 coaE Haemophilus influenzae Rd KW20 dephospho-CoA kinase NP_439051.1 944299 D 71421 CDS NP_439052.1 16273639 949368 944912..945118 1 NC_000907.1 zinc-binding protein 945118 949368 HI0891m Haemophilus influenzae Rd KW20 zinc-binding protein NP_439052.1 944912 D 71421 CDS NP_439053.1 16272830 949895 945227..946483 1 NC_000907.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB 946483 rhlB 949895 rhlB Haemophilus influenzae Rd KW20 ATP-dependent RNA helicase RhlB NP_439053.1 945227 D 71421 CDS NP_439054.1 16272831 949896 946725..947288 1 NC_000907.1 Bm3T1; similar to GB:S87512 SP:P43506 PID:623036 PID:247052; transcriptional repressor 947288 949896 HI0893 Haemophilus influenzae Rd KW20 transcriptional repressor NP_439054.1 946725 D 71421 CDS NP_439055.1 16272832 949897 947368..948516 1 NC_000907.1 similar to GB:U14993 SP:P43505 PID:438192 PID:550460; membrane-fusion protein 948516 949897 HI0894 Haemophilus influenzae Rd KW20 membrane-fusion protein NP_439055.1 947368 D 71421 CDS NP_439056.1 16272833 949898 948516..951614 1 NC_000907.1 similar to GB:M94248 SP:P31224 GB:U00734 PID:290406 PID:532311; acriflavine resistance protein 951614 acrB 949898 acrB Haemophilus influenzae Rd KW20 acriflavine resistance protein NP_439056.1 948516 D 71421 CDS NP_439057.1 16272834 949899 952004..952618 1 NC_000907.1 similar to GB:L19201 SP:P29131 GB:L14281 PID:290448 PID:305036; cell division protein 952618 ftsN 949899 ftsN Haemophilus influenzae Rd KW20 cell division protein NP_439057.1 952004 D 71421 CDS NP_439058.1 16272835 949901 complement(952635..954167) 1 NC_000907.1 similar to GB:M86657 SP:P27304 PID:145836 GB:U00096 PID:1789042; multidrug resistance protein B 954167 emrB 949901 emrB Haemophilus influenzae Rd KW20 multidrug resistance protein B NP_439058.1 952635 R 71421 CDS NP_439059.1 16272836 949904 complement(954177..955349) 1 NC_000907.1 similar to GB:M86657 SP:P27303 PID:145835 GB:U00096 PID:1789041; multidrug resistance protein A 955349 emrA 949904 emrA Haemophilus influenzae Rd KW20 multidrug resistance protein A NP_439059.1 954177 R 71421 CDS NP_439060.1 16272837 949905 complement(955532..956014) 1 NC_000907.1 similar to GB:D10483 SP:P00379 GB:J01609 GB:J01609 GB:X05108; dihydrofolate reductase 956014 folA 949905 folA Haemophilus influenzae Rd KW20 dihydrofolate reductase NP_439060.1 955532 R 71421 CDS NP_439061.1 16272838 949633 956115..957221 1 NC_000907.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 957221 proB 949633 proB Haemophilus influenzae Rd KW20 gamma-glutamyl kinase NP_439061.1 956115 D 71421 CDS NP_439062.1 16272839 950618 957302..957892 1 NC_000907.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 957892 950618 HI0901 Haemophilus influenzae Rd KW20 dinucleoside polyphosphate hydrolase NP_439062.1 957302 D 71421 CDS NP_439063.1 16272840 949698 957892..958686 1 NC_000907.1 similar to GB:L77117 SP:Q57883 PID:1591145; hypothetical protein 958686 949698 HI0902 Haemophilus influenzae Rd KW20 hypothetical protein NP_439063.1 957892 D 71421 CDS NP_439064.1 16272841 950017 958695..959501 1 NC_000907.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 959501 lgt 950017 lgt Haemophilus influenzae Rd KW20 prolipoprotein diacylglyceryl transferase NP_439064.1 958695 D 71421 CDS NP_439065.1 16272842 949907 959511..960362 1 NC_000907.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 960362 thyA 949907 thyA Haemophilus influenzae Rd KW20 thymidylate synthase NP_439065.1 959511 D 71421 CDS NP_439066.1 16272843 949908 960362..960883 1 NC_000907.1 similar to SP:P30134 PID:296183 PID:987637 PID:1033148 GB:U00096; hypothetical protein 960883 949908 HI0906 Haemophilus influenzae Rd KW20 hypothetical protein NP_439066.1 960362 D 71421 CDS NP_439067.1 16272844 949909 complement(960911..961225) 1 NC_000907.1 hypothetical protein 961225 949909 HI0907 Haemophilus influenzae Rd KW20 hypothetical protein NP_439067.1 960911 R 71421 CDS NP_439068.1 16272845 949910 961305..961607 1 NC_000907.1 hypothetical protein 961607 949910 HI0908 Haemophilus influenzae Rd KW20 hypothetical protein NP_439068.1 961305 D 71421 CDS NP_439069.1 16272846 949911 961732..964437 1 NC_000907.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 964437 secA 949911 secA Haemophilus influenzae Rd KW20 preprotein translocase subunit SecA NP_439069.1 961732 D 71421 CDS NP_439070.1 16272847 949912 964502..964912 1 NC_000907.1 MutT; similar to GB:D10483 SP:P08337 GB:M20791 GB:X04831 PID:147795; mutator protein 964912 mutT 949912 mutT Haemophilus influenzae Rd KW20 mutator protein NP_439070.1 964502 D 71421 CDS NP_439071.1 16272848 950431 965021..966877 1 NC_000907.1 similar to GB:D10483 SP:P03819 GB:X56742 PID:216472 PID:41875; glutathione-regulated potassium efflux system protein 966877 kefC 950431 kefC Haemophilus influenzae Rd KW20 glutathione-regulated potassium efflux system protein NP_439071.1 965021 D 71421 CDS NP_439072.1 16272849 950836 966978..967742 1 NC_000907.1 hypothetical protein 967742 950836 HI0912 Haemophilus influenzae Rd KW20 hypothetical protein NP_439072.1 966978 D 71421 CDS NP_439073.2 161350022 949913 967920..968642 1 NC_000907.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 968642 rpsB 949913 rpsB Haemophilus influenzae Rd KW20 30S ribosomal protein S2 NP_439073.2 967920 D 71421 CDS NP_439074.1 16272851 949917 968775..969626 1 NC_000907.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 969626 tsf 949917 tsf Haemophilus influenzae Rd KW20 elongation factor Ts NP_439074.1 968775 D 71421 CDS NP_439075.1 16272852 949919 complement(969806..970831) 1 NC_000907.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 970831 lpxD 949919 lpxD Haemophilus influenzae Rd KW20 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase NP_439075.1 969806 R 71421 CDS NP_439076.1 16272853 949929 complement(970844..971437) 1 NC_000907.1 similar to PID:1935023; outer membrane protein 971437 949929 HI0916 Haemophilus influenzae Rd KW20 outer membrane protein NP_439076.1 970844 R 71421 CDS NP_439077.1 16272854 949634 complement(971545..973932) 1 NC_000907.1 similar to GB:U13961 PID:1573938 PID:2231192 PID:2231195; protective surface antigen D15 973932 949634 HI0917 Haemophilus influenzae Rd KW20 protective surface antigen D15 NP_439077.1 971545 R 71421 CDS NP_439078.1 16272855 949920 complement(973952..975283) 1 NC_000907.1 similar to SP:P37764 PID:1208948 GB:U00096 PID:1552753 PID:1786373; hypothetical protein 975283 949920 HI0918 Haemophilus influenzae Rd KW20 hypothetical protein NP_439078.1 973952 R 71421 CDS NP_439079.1 16272856 949391 complement(975293..976159) 1 NC_000907.1 similar to GB:M11330 SP:P06466 PID:1208947 PID:145476 GB:U00096; CDP-diglyceride synthetase 976159 cdsA 949391 cdsA Haemophilus influenzae Rd KW20 CDP-diglyceride synthetase NP_439079.1 975293 R 71421 CDS NP_439080.1 16272857 950624 complement(976177..976896) 1 NC_000907.1 similar to PID:1208946 GB:U00096 SP:Q47675 PID:1552751 PID:1786371; hypothetical protein 976896 950624 HI0920 Haemophilus influenzae Rd KW20 hypothetical protein NP_439080.1 976177 R 71421 CDS NP_439081.1 16272858 949390 977145..979730 1 NC_000907.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 979730 leuS 949390 leuS Haemophilus influenzae Rd KW20 leucyl-tRNA synthetase NP_439081.1 977145 D 71421 CDS NP_439082.2 30995409 950738 979825..980328 1 NC_000907.1 similar to GB:M18277 SP:P10101 PID:147663 GB:U00096 PID:1651268; rare lipoprotein B 980328 950738 HI0922 Haemophilus influenzae Rd KW20 rare lipoprotein B NP_439082.2 979825 D 71421 CDS NP_439083.1 16272860 949921 980328..981362 1 NC_000907.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 981362 holA 949921 holA Haemophilus influenzae Rd KW20 DNA polymerase III subunit delta NP_439083.1 980328 D 71421 CDS NP_439084.1 16272861 949922 complement(981597..983663) 1 NC_000907.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 983663 glyS 949922 glyS Haemophilus influenzae Rd KW20 glycyl-tRNA synthetase subunit beta NP_439084.1 981597 R 71421 CDS NP_439085.1 16272862 950812 complement(984000..984365) 1 NC_000907.1 similar to SP:P45736 GB:U00096 PID:1279405 PID:1787546; hypothetical protein 984365 950812 HI0925 Haemophilus influenzae Rd KW20 hypothetical protein NP_439085.1 984000 R 71421 CDS NP_439086.1 16272863 949651 complement(984395..984655) 1 NC_000907.1 hypothetical protein 984655 949651 HI0926 Haemophilus influenzae Rd KW20 hypothetical protein NP_439086.1 984395 R 71421 CDS NP_439087.1 16272864 950664 complement(984714..985622) 1 NC_000907.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 985622 glyQ 950664 glyQ Haemophilus influenzae Rd KW20 glycyl-tRNA synthetase subunit alpha NP_439087.1 984714 R 71421 CDS NP_439088.1 16272865 949926 985888..987414 1 NC_000907.1 similar to GB:U02682 PID:1573949; catalase 987414 hktE 949926 hktE Haemophilus influenzae Rd KW20 catalase NP_439088.1 985888 D 71421 CDS NP_439089.1 16272866 949927 complement(987646..988827) 1 NC_000907.1 similar to GB:M77129 SP:P24196 PID:146678 PID:882568 GB:U00096; hypothetical protein 988827 949927 HI0929 Haemophilus influenzae Rd KW20 hypothetical protein NP_439089.1 987646 R 71421 CDS NP_439090.1 16272867 949932 complement(988828..989448) 1 NC_000907.1 hypothetical protein 989448 949932 HI0930 Haemophilus influenzae Rd KW20 hypothetical protein NP_439090.1 988828 R 71421 CDS NP_439091.2 30995410 949933 complement(989421..989840) 1 NC_000907.1 hypothetical protein 989840 949933 HI0931 Haemophilus influenzae Rd KW20 hypothetical protein NP_439091.2 989421 R 71421 CDS NP_439092.1 16272869 949935 complement(989924..991234) 1 NC_000907.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 991234 eno 949935 eno Haemophilus influenzae Rd KW20 phosphopyruvate hydratase NP_439092.1 989924 R 71421 CDS NP_439093.1 16272870 949936 complement(991355..992560) 1 NC_000907.1 similar to SP:P37631 PID:912464 GB:U00096 PID:2367234; hypothetical protein 992560 949936 HI0933 Haemophilus influenzae Rd KW20 hypothetical protein NP_439093.1 991355 R 71421 CDS NP_439094.1 16272871 949938 complement(992557..993711) 1 NC_000907.1 similar to SP:P32711 GB:X72298 PID:396410 PID:404307 GB:U00096; cytochrome C-type biogenesis protein 993711 nrfF 949938 nrfF Haemophilus influenzae Rd KW20 cytochrome C-type biogenesis protein NP_439094.1 992557 R 71421 CDS NP_439095.1 16272872 949930 complement(993708..994238) 1 NC_000907.1 similar to SP:P33926 PID:405920 GB:U00096 PID:1788523; thiol-disulfide interchange protein 994238 dsbE 949930 dsbE Haemophilus influenzae Rd KW20 thiol-disulfide interchange protein NP_439095.1 993708 R 71421 CDS NP_439096.1 16272873 950731 complement(994238..996145) 1 NC_000907.1 similar to SP:P32710 GB:X72298 PID:581146 GB:U00096 PID:1790511; cytochrome C-type biogenesis 996145 950731 HI0936 Haemophilus influenzae Rd KW20 cytochrome C-type biogenesis NP_439096.1 994238 R 71421 CDS NP_439097.1 16272874 949915 complement(996254..997057) 1 NC_000907.1 similar to GB:M34828 SP:P22783 PID:147899 GB:U00096 PID:1788882; extragenic suppressor 997057 suhB 949915 suhB Haemophilus influenzae Rd KW20 extragenic suppressor NP_439097.1 996254 R 71421 CDS NP_439098.1 16272875 949906 997258..997770 1 NC_000907.1 hypothetical protein 997770 949906 HI0938 Haemophilus influenzae Rd KW20 hypothetical protein NP_439098.1 997258 D 71421 CDS NP_439099.1 16272876 949939 997770..998486 1 NC_000907.1 hypothetical protein 998486 949939 HI0939 Haemophilus influenzae Rd KW20 hypothetical protein NP_439099.1 997770 D 71421 CDS NP_439100.1 16272877 949941 998486..999169 1 NC_000907.1 hypothetical protein 999169 949941 HI0940 Haemophilus influenzae Rd KW20 hypothetical protein NP_439100.1 998486 D 71421 CDS NP_439101.1 16272878 950292 999144..999449 1 NC_000907.1 hypothetical protein 999449 950292 HI0941 Haemophilus influenzae Rd KW20 hypothetical protein NP_439101.1 999144 D 71421 CDS NP_439102.1 16272879 950610 999495..1002860 1 NC_000907.1 similar to SP:P07648 PID:42689 PID:882714 GB:U00096 PID:1789186; exodeoxyribonuclease V subunit gamma 1002860 recC 950610 recC Haemophilus influenzae Rd KW20 exodeoxyribonuclease V subunit gamma NP_439102.1 999495 D 71421 CDS NP_439103.1 16272880 949508 1002915..1003364 1 NC_000907.1 similar to SP:P25538 GB:X64395 PID:42148 GB:U00096 PID:1773097; transcriptional regulator NrdR 1003364 nrdR 949508 nrdR Haemophilus influenzae Rd KW20 transcriptional regulator NrdR NP_439103.1 1002915 D 71421 CDS NP_439104.1 16272881 949944 1003367..1004485 1 NC_000907.1 similar to SP:P25539 GB:X64395 PID:581147 GB:U00096 PID:1773098; riboflavin biosynthesis protein 1004485 ribD 949944 ribD Haemophilus influenzae Rd KW20 riboflavin biosynthesis protein NP_439104.1 1003367 D 71421 CDS NP_439105.1 16272882 949947 1004486..1005508 1 NC_000907.1 similar to SP:P31137 GB:U15661 GB:U00096 PID:1789630; protease 1005508 degS 949947 degS Haemophilus influenzae Rd KW20 protease NP_439105.1 1004486 D 71421 CDS NP_439106.1 16272883 949949 complement(1005582..1006397) 1 NC_000907.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 1006397 fpg 949949 fpg Haemophilus influenzae Rd KW20 formamidopyrimidine-DNA glycosylase NP_439106.1 1005582 R 71421 CDS NP_439107.1 16272884 950216 complement(1006630..1008165) 1 NC_000907.1 similar to PID:893355; L-24-diaminobutyrate decarboxylase 1008165 950216 HI0946.1 Haemophilus influenzae Rd KW20 L-24-diaminobutyrate decarboxylase NP_439107.1 1006630 R 71421 CDS NP_439108.1 16272885 950223 complement(1008185..1008583) 1 NC_000907.1 similar to GB:L22308 GB:L31763 GB:M74565 PID:145068 PID:438534; virulence-associated protein C 1008583 vapC 950223 vapC Haemophilus influenzae Rd KW20 virulence-associated protein C NP_439108.1 1008185 R 71421 CDS NP_439109.1 16272886 949840 complement(1008583..1008816) 1 NC_000907.1 similar to SP:P18355; hypothetical protein 1008816 949840 HI0948 Haemophilus influenzae Rd KW20 hypothetical protein NP_439109.1 1008583 R 71421 CDS NP_439110.1 16272887 949951 complement(1008963..1010327) 1 NC_000907.1 catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde; diaminobutyrate--2-oxoglutarate aminotransferase 1010327 949951 HI0949 Haemophilus influenzae Rd KW20 diaminobutyrate--2-oxoglutarate aminotransferase NP_439110.1 1008963 R 71421 CDS NP_439111.1 16272888 949952 complement(1010675..1010845) 1 NC_000907.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 1010845 rpmG 949952 rpmG Haemophilus influenzae Rd KW20 50S ribosomal protein L33 NP_439111.1 1010675 R 71421 CDS NP_439112.1 16272889 949955 complement(1010857..1011093) 1 NC_000907.1 required for 70S ribosome assembly; 50S ribosomal protein L28 1011093 rpmB 949955 rpmB Haemophilus influenzae Rd KW20 50S ribosomal protein L28 NP_439112.1 1010857 R 71421 CDS NP_439113.2 30995411 949958 complement(1011307..1011972) 1 NC_000907.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 1011972 radC 949958 radC Haemophilus influenzae Rd KW20 DNA repair protein RadC NP_439113.2 1011307 R 71421 CDS NP_439114.1 16272891 949948 1012136..1013338 1 NC_000907.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 1013338 dfp 949948 dfp Haemophilus influenzae Rd KW20 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase NP_439114.1 1012136 D 71421 CDS NP_439115.1 16272892 949940 1013386..1013841 1 NC_000907.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 1013841 dut 949940 dut Haemophilus influenzae Rd KW20 deoxyuridine 5'-triphosphate nucleotidohydrolase NP_439115.1 1013386 D 71421 CDS NP_439116.1 16272893 949937 1013845..1014501 1 NC_000907.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 1014501 slmA 949937 slmA Haemophilus influenzae Rd KW20 nucleoid occlusion protein NP_439116.1 1013845 D 71421 CDS NP_439118.1 16272895 949963 1014760..1015434 1 NC_000907.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 1015434 crp 949963 crp Haemophilus influenzae Rd KW20 cAMP-regulatory protein NP_439118.1 1014760 D 71421 CDS NP_439119.1 16272896 949964 complement(1015799..1016977) 1 NC_000907.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 1016977 rumB 949964 rumB Haemophilus influenzae Rd KW20 23S rRNA methyluridine methyltransferase NP_439119.1 1015799 R 71421 CDS NP_439120.1 16272897 949658 complement(1016970..1018025) 1 NC_000907.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1018025 exoII 949658 exoII Haemophilus influenzae Rd KW20 beta-hexosaminidase NP_439120.1 1016970 R 71421 CDS NP_439121.1 16272898 950757 complement(1018029..1018379) 1 NC_000907.1 hypothetical protein 1018379 950757 HI0960 Haemophilus influenzae Rd KW20 hypothetical protein NP_439121.1 1018029 R 71421 CDS NP_439122.2 30995412 950594 complement(1018379..1018729) 1 NC_000907.1 similar to SP:P44956; HIT-like protein 1018729 950594 HI0961 Haemophilus influenzae Rd KW20 HIT-like protein NP_439122.2 1018379 R 71421 CDS NP_439124.1 16272900 949965 complement(1021700..1022638) 1 NC_000907.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1022638 ribF 949965 ribF Haemophilus influenzae Rd KW20 bifunctional riboflavin kinase/FMN adenylyltransferase NP_439124.1 1021700 R 71421 CDS NP_439125.1 16272901 950595 complement(1022673..1024205) 1 NC_000907.1 similar to GB:D25292 SP:P37169 GB:Z26133 PID:438252 PID:505363; virulence factor 1024205 mviN 950595 mviN Haemophilus influenzae Rd KW20 virulence factor NP_439125.1 1022673 R 71421 CDS NP_439126.2 30995413 950750 1024514..1024777 1 NC_000907.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 1024777 rpsT 950750 rpsT Haemophilus influenzae Rd KW20 30S ribosomal protein S20 NP_439126.2 1024514 D 71421 CDS NP_439127.1 16272903 950444 complement(1024850..1025416) 1 NC_000907.1 hypothetical protein 1025416 950444 HI0966 Haemophilus influenzae Rd KW20 hypothetical protein NP_439127.1 1024850 R 71421 CDS NP_439128.1 16272904 949914 1025442..1025546 1 NC_000907.1 hypothetical protein 1025546 949914 HI0967 Haemophilus influenzae Rd KW20 hypothetical protein NP_439128.1 1025442 D 71421 CDS NP_439129.1 16272905 949967 1025562..1026419 1 NC_000907.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 1026419 menB 949967 menB Haemophilus influenzae Rd KW20 naphthoate synthase NP_439129.1 1025562 D 71421 CDS NP_439130.2 30995414 949968 1026452..1027477 1 NC_000907.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 1027477 menC 949968 menC Haemophilus influenzae Rd KW20 O-succinylbenzoate synthase NP_439130.2 1026452 D 71421 CDS NP_439131.1 16272907 949969 1027535..1027984 1 NC_000907.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 1027984 aroQ 949969 aroQ Haemophilus influenzae Rd KW20 3-dehydroquinate dehydratase NP_439131.1 1027535 D 71421 CDS NP_439132.1 16272908 949974 1028137..1028604 1 NC_000907.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 1028604 accB 949974 accB Haemophilus influenzae Rd KW20 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit NP_439132.1 1028137 D 71421 CDS NP_439133.1 16272909 949398 1028779..1030125 1 NC_000907.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 1030125 accC 949398 accC Haemophilus influenzae Rd KW20 acetyl-CoA carboxylase biotin carboxylase subunit NP_439133.1 1028779 D 71421 CDS NP_439134.1 16272910 949511 1030275..1031144 1 NC_000907.1 hypothetical protein 1031144 949511 HI0973 Haemophilus influenzae Rd KW20 hypothetical protein NP_439134.1 1030275 D 71421 CDS NP_439136.1 16272911 949407 1032765..1033022 1 NC_000907.1 similar to SP:P45566 PID:606197 GB:U00096 PID:1789655; hypothetical protein 1033022 949407 HI0974.1 Haemophilus influenzae Rd KW20 hypothetical protein NP_439136.1 1032765 D 71421 CDS NP_439137.1 16272912 950256 1033019..1034473 1 NC_000907.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 1034473 panF 950256 panF Haemophilus influenzae Rd KW20 sodium/panthothenate symporter NP_439137.1 1033019 D 71421 CDS NP_439140.1 16272915 949973 1035466..1036041 1 NC_000907.1 similar to GB:M28363 SP:P20605 PID:145955 PID:147054 PID:606295; cell filamentation protein 1036041 fic 949973 fic Haemophilus influenzae Rd KW20 cell filamentation protein NP_439140.1 1035466 D 71421 CDS NP_439141.1 16272916 949962 1036082..1036972 1 NC_000907.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 1036972 prmA 949962 prmA Haemophilus influenzae Rd KW20 ribosomal protein L11 methyltransferase NP_439141.1 1036082 D 71421 CDS NP_439142.1 16272917 949982 1037121..1038113 1 NC_000907.1 similar to SP:P45672 PID:599600; hypothetical protein 1038113 949982 HI0979 Haemophilus influenzae Rd KW20 hypothetical protein NP_439142.1 1037121 D 71421 CDS NP_439143.1 16272918 949985 1038094..1038393 1 NC_000907.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 1038393 fis 949985 fis Haemophilus influenzae Rd KW20 DNA-binding protein Fis NP_439143.1 1038094 D 71421 CDS NP_439144.1 16272919 950039 complement(1038488..1038973) 1 NC_000907.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 1038973 smpB 950039 smpB Haemophilus influenzae Rd KW20 SsrA-binding protein NP_439144.1 1038488 R 71421 CDS NP_439145.1 16272920 949556 complement(1039212..1040177) 1 NC_000907.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 1040177 pfkA 949556 pfkA Haemophilus influenzae Rd KW20 6-phosphofructokinase NP_439145.1 1039212 R 71421 CDS NP_439146.1 16272921 949986 complement(1040273..1040854) 1 NC_000907.1 hypothetical protein 1040854 949986 HI0983 Haemophilus influenzae Rd KW20 hypothetical protein NP_439146.1 1040273 R 71421 CDS NP_439147.2 30995415 949993 complement(1040847..1041623) 1 NC_000907.1 similar to GB:D10483 SP:P11288 PID:216438 PID:537248 PID:1128976; hypothetical protein 1041623 949993 HI0984 Haemophilus influenzae Rd KW20 hypothetical protein NP_439147.2 1040847 R 71421 CDS NP_439148.1 16272923 949984 complement(1041677..1042798) 1 NC_000907.1 similar to GB:L42023 SP:P43862 PID:1006171 PID:1221098 PID:609332; DNA processing chain A 1042798 dprA 949984 dprA Haemophilus influenzae Rd KW20 DNA processing chain A NP_439148.1 1041677 R 71421 CDS NP_439149.2 30995416 949987 1043355..1044902 1 NC_000907.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 1044902 leuA 949987 leuA Haemophilus influenzae Rd KW20 2-isopropylmalate synthase NP_439149.2 1043355 D 71421 CDS NP_439150.1 16272925 949989 1044988..1046064 1 NC_000907.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 1046064 leuB 949989 leuB Haemophilus influenzae Rd KW20 3-isopropylmalate dehydrogenase NP_439150.1 1044988 D 71421 CDS NP_439151.1 16272926 950815 1046240..1047649 1 NC_000907.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 1047649 leuC 950815 leuC Haemophilus influenzae Rd KW20 isopropylmalate isomerase large subunit NP_439151.1 1046240 D 71421 CDS NP_439152.1 16272927 949559 1047673..1048275 1 NC_000907.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 1048275 leuD 949559 leuD Haemophilus influenzae Rd KW20 isopropylmalate isomerase small subunit NP_439152.1 1047673 D 71421 CDS NP_439153.1 16272928 950762 complement(1048389..1053473) 1 NC_000907.1 similar to GB:M87489; immunoglobin A1 protease 1053473 iga1 950762 iga1 Haemophilus influenzae Rd KW20 immunoglobin A1 protease NP_439153.1 1048389 R 71421 CDS NP_439154.1 16272929 949990 complement(1053715..1054794) 1 NC_000907.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 1054794 recF 949990 recF Haemophilus influenzae Rd KW20 recombination protein F NP_439154.1 1053715 R 71421 CDS NP_439155.1 16272930 949992 complement(1054796..1055896) 1 NC_000907.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 1055896 dnaN 949992 dnaN Haemophilus influenzae Rd KW20 DNA polymerase III subunit beta NP_439155.1 1054796 R 71421 CDS NP_439156.1 16272931 950755 complement(1055909..1057273) 1 NC_000907.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1057273 dnaA 950755 dnaA Haemophilus influenzae Rd KW20 chromosomal replication initiation protein NP_439156.1 1055909 R 71421 CDS NP_439157.1 16272932 950660 complement(1057465..1060203) 1 NC_000907.1 similar to GB:Z15129 SP:Q06987 GB:S64486 GB:X75168 PID:297044; transferrin-binding protein 1 1060203 tbp1 950660 tbp1 Haemophilus influenzae Rd KW20 transferrin-binding protein 1 NP_439157.1 1057465 R 71421 CDS NP_439158.1 16272933 950797 complement(1060231..1062108) 1 NC_000907.1 similar to PID:1177569; transferrin-binding protein 2 1062108 tbp2 950797 tbp2 Haemophilus influenzae Rd KW20 transferrin-binding protein 2 NP_439158.1 1060231 R 71421 CDS NP_439160.1 16272934 949994 1063832..1063966 1 NC_000907.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 1063966 rpmH 949994 rpmH Haemophilus influenzae Rd KW20 50S ribosomal protein L34 NP_439160.1 1063832 D 71421 CDS NP_439161.1 16272935 950612 1063986..1064345 1 NC_000907.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 1064345 rnpA 950612 rnpA Haemophilus influenzae Rd KW20 ribonuclease P NP_439161.1 1063986 D 71421 CDS NP_439162.1 16272936 949902 1064309..1064569 1 NC_000907.1 similar to PID:1005414; hypothetical protein 1064569 949902 HI1000 Haemophilus influenzae Rd KW20 hypothetical protein NP_439162.1 1064309 D 71421 CDS NP_439163.1 16272937 949995 1064569..1066194 1 NC_000907.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 1066194 yidC 949995 yidC Haemophilus influenzae Rd KW20 inner membrane protein translocase component YidC NP_439163.1 1064569 D 71421 CDS NP_439164.1 16272938 949988 1066325..1067710 1 NC_000907.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 1067710 trmE 949988 trmE Haemophilus influenzae Rd KW20 tRNA modification GTPase TrmE NP_439164.1 1066325 D 71421 CDS NP_439165.2 30995417 950512 join(1067898..1068025,1068027..1069767) 1 NC_000907.1 contains frameshifts; similar to GB:U00096 SP:P77241 PID:1580712 PID:1773125 PID:1786645; peptidyl-prolyl cis-trans isomerase 1069767 950512 HI1004 Haemophilus influenzae Rd KW20 peptidyl-prolyl cis-trans isomerase NP_439165.2 1067898 D 71421 CDS NP_439166.1 16272940 949997 1069855..1071414 1 NC_000907.1 similar to HI1064; similar to GB:U00096 SP:P75785 PID:1787035; hypothetical protein 1071414 949997 HI1005 Haemophilus influenzae Rd KW20 hypothetical protein NP_439166.1 1069855 D 71421 CDS NP_439167.1 16272941 949998 1071484..1071999 1 NC_000907.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 1071999 lspA 949998 lspA Haemophilus influenzae Rd KW20 lipoprotein signal peptidase NP_439167.1 1071484 D 71421 CDS NP_439168.1 16272942 950001 1071996..1072940 1 NC_000907.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1072940 ispH 950001 ispH Haemophilus influenzae Rd KW20 4-hydroxy-3-methylbut-2-enyl diphosphate reductase NP_439168.1 1071996 D 71421 CDS NP_439169.1 16272943 950002 1073118..1073456 1 NC_000907.1 similar to GB:U00096 SP:P77415 PID:1580713 PID:1773126 PID:1786646; hypothetical protein 1073456 950002 HI1008 Haemophilus influenzae Rd KW20 hypothetical protein NP_439169.1 1073118 D 71421 CDS NP_439170.1 16272944 950712 complement(1073504..1074274) 1 NC_000907.1 similar to SP:P09392 GB:M96795 PID:146186 PID:606358 GB:U00096; glycerol-3-phosphate regulon repressor 1074274 glpR 950712 glpR Haemophilus influenzae Rd KW20 glycerol-3-phosphate regulon repressor NP_439170.1 1073504 R 71421 CDS NP_439171.1 16272945 950607 1074433..1075338 1 NC_000907.1 similar to PID:882629 GB:U00096 PID:1789092; 3-hydroxyisobutyrate dehydrogenase 1075338 950607 HI1010 Haemophilus influenzae Rd KW20 3-hydroxyisobutyrate dehydrogenase NP_439171.1 1074433 D 71421 CDS NP_439172.1 16272946 950004 1075341..1076582 1 NC_000907.1 similar to PID:882630 GB:U00096 PID:1789093; hypothetical protein 1076582 950004 HI1011 Haemophilus influenzae Rd KW20 hypothetical protein NP_439172.1 1075341 D 71421 CDS NP_439173.1 16272947 950005 1076579..1077211 1 NC_000907.1 similar to PID:882631 GB:U00096 SP:Q46890 PID:1789094; aldolase 1077211 950005 HI1012 Haemophilus influenzae Rd KW20 aldolase NP_439173.1 1076579 D 71421 CDS NP_439174.1 16272948 950733 1077214..1077990 1 NC_000907.1 similar to PID:882632 GB:U00096 SP:Q46891 PID:1789095; hypothetical protein 1077990 950733 HI1013 Haemophilus influenzae Rd KW20 hypothetical protein NP_439174.1 1077214 D 71421 CDS NP_439175.1 16272949 950006 1078046..1078993 1 NC_000907.1 similar to PID:695275; hypothetical protein 1078993 950006 HI1014 Haemophilus influenzae Rd KW20 hypothetical protein NP_439175.1 1078046 D 71421 CDS NP_439176.1 16272950 950013 1079002..1080468 1 NC_000907.1 similar to SP:P39835 PID:606350 GB:U00096 PID:1789820; gluconate permease 1080468 gntP 950013 gntP Haemophilus influenzae Rd KW20 gluconate permease NP_439176.1 1079002 D 71421 CDS NP_439177.1 16272951 949991 1080488..1080916 1 NC_000907.1 hypothetical protein 1080916 949991 HI1016 Haemophilus influenzae Rd KW20 hypothetical protein NP_439177.1 1080488 D 71421 CDS NP_439179.1 16272953 949440 1082773..1083771 1 NC_000907.1 similar to GB:D10483 SP:P31550 GB:U09984 PID:216488 PID:497658; thiamin ABC transporter substrate-binding protein 1083771 tbpA 949440 tbpA Haemophilus influenzae Rd KW20 thiamin ABC transporter substrate-binding protein NP_439179.1 1082773 D 71421 CDS NP_439180.1 16272954 950718 1083776..1085392 1 NC_000907.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein 1085392 thiP 950718 thiP Haemophilus influenzae Rd KW20 thiamine transporter membrane protein NP_439180.1 1083776 D 71421 CDS NP_439181.1 16272955 950003 1085376..1086023 1 NC_000907.1 similar to GB:D10483 SP:P31548 PID:216486 GB:U00096 PID:1786253; thiamin ABC transporter ATP-binding protein 1086023 950003 HI1021 Haemophilus influenzae Rd KW20 thiamin ABC transporter ATP-binding protein NP_439181.1 1085376 D 71421 CDS NP_439182.1 16272956 950009 1086136..1087137 1 NC_000907.1 similar to GB:J04423 SP:P12996 PID:145425 PID:490219 GB:U00096; biotin synthetase 1087137 bioB 950009 bioB Haemophilus influenzae Rd KW20 biotin synthetase NP_439182.1 1086136 D 71421 CDS NP_439183.1 16272957 949889 complement(1087262..1089259) 1 NC_000907.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1089259 tktA 949889 tktA Haemophilus influenzae Rd KW20 transketolase NP_439183.1 1087262 R 71421 CDS NP_439184.1 16272958 950714 complement(1089388..1090065) 1 NC_000907.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 1090065 ulaD 950714 ulaD Haemophilus influenzae Rd KW20 3-keto-L-gulonate-6-phosphate decarboxylase NP_439184.1 1089388 R 71421 CDS NP_439185.1 16272959 950011 complement(1090115..1090810) 1 NC_000907.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 1090810 sgbE 950011 sgbE Haemophilus influenzae Rd KW20 L-ribulose-5-phosphate 4-epimerase NP_439185.1 1090115 R 71421 CDS NP_439186.1 16272960 950012 complement(1090804..1091664) 1 NC_000907.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; L-xylulose 5-phosphate 3-epimerase 1091664 950012 HI1026 Haemophilus influenzae Rd KW20 L-xylulose 5-phosphate 3-epimerase NP_439186.1 1090804 R 71421 CDS NP_439187.1 16272961 949892 complement(1091678..1093135) 1 NC_000907.1 similar to SP:P37677 PID:466718 GB:U00096 PID:1790005; L-xylulose kinase 1093135 lyx 949892 lyx Haemophilus influenzae Rd KW20 L-xylulose kinase NP_439187.1 1091678 R 71421 CDS NP_439188.1 16272962 949528 complement(1093194..1094180) 1 NC_000907.1 similar to SP:P37676 PID:466717 GB:U00096 PID:1790004; hypothetical protein 1094180 949528 HI1028 Haemophilus influenzae Rd KW20 hypothetical protein NP_439188.1 1093194 R 71421 CDS NP_439189.1 16272963 949652 complement(1094211..1095488) 1 NC_000907.1 similar to SP:P37675 PID:466716 GB:U00096 PID:1790003; hypothetical protein 1095488 949652 HI1029 Haemophilus influenzae Rd KW20 hypothetical protein NP_439189.1 1094211 R 71421 CDS NP_439190.1 16272964 950014 complement(1095485..1095970) 1 NC_000907.1 similar to SP:P37674 PID:466715 GB:U00096 PID:1790002; hypothetical protein 1095970 950014 HI1030 Haemophilus influenzae Rd KW20 hypothetical protein NP_439190.1 1095485 R 71421 CDS NP_439191.1 16272965 950015 complement(1096042..1097040) 1 NC_000907.1 NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; 2,3-diketo-L-gulonate reductase 1097040 950015 HI1031 Haemophilus influenzae Rd KW20 2,3-diketo-L-gulonate reductase NP_439191.1 1096042 R 71421 CDS NP_439192.1 16272966 950700 1097216..1098022 1 NC_000907.1 similar to SP:P37671 PID:466712 GB:U00096 PID:1789999; transcriptional regulator 1098022 950700 HI1032 Haemophilus influenzae Rd KW20 transcriptional regulator NP_439192.1 1097216 D 71421 CDS NP_439193.1 16272967 949401 1098172..1099116 1 NC_000907.1 catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 1099116 serB 949401 serB Haemophilus influenzae Rd KW20 phosphoserine phosphatase NP_439193.1 1098172 D 71421 CDS NP_439194.1 16272968 950728 1099134..1099625 1 NC_000907.1 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein 1099625 950728 HI1034 Haemophilus influenzae Rd KW20 nucleotide-binding protein NP_439194.1 1099134 D 71421 CDS NP_439195.1 16272969 950726 1099920..1100867 1 NC_000907.1 responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 1100867 corA 950726 corA Haemophilus influenzae Rd KW20 magnesium/nickel/cobalt transporter CorA NP_439195.1 1099920 D 71421 CDS NP_439196.2 30995418 950018 1100867..1101412 1 NC_000907.1 similar to PID:801880 SP:P52059 PID:801882; hypothetical protein 1101412 950018 HI1036 Haemophilus influenzae Rd KW20 hypothetical protein NP_439196.2 1100867 D 71421 CDS NP_439197.1 16272971 950020 complement(1101593..1102477) 1 NC_000907.1 similar to PID:984579 GB:U00096 SP:Q47147 PID:1552793 PID:1786417; hypothetical protein 1102477 950020 HI1037 Haemophilus influenzae Rd KW20 hypothetical protein NP_439197.1 1101593 R 71421 CDS NP_439198.1 16272972 950021 1102856..1104058 1 NC_000907.1 similar to GB:L77117 PID:1592175; hypothetical protein 1104058 950021 HI1038 Haemophilus influenzae Rd KW20 hypothetical protein NP_439198.1 1102856 D 71421 CDS NP_439199.1 16272973 950604 1104411..1105415 1 NC_000907.1 similar to SP:P25261 SP:P24599 PID:43474; urease accessory protein 1105415 ureF 950604 ureF Haemophilus influenzae Rd KW20 urease accessory protein NP_439199.1 1104411 D 71421 CDS NP_439200.1 16272974 950661 1105412..1106326 1 NC_000907.1 similar to SP:P24600 SP:P25267 PID:43482; modification methylase 1106326 950661 HI1041 Haemophilus influenzae Rd KW20 modification methylase NP_439200.1 1105412 D 71421 CDS NP_439202.1 16272975 950023 complement(1108431..1108931) 1 NC_000907.1 similar to SP:P33939 PID:453990 GB:U00096 PID:1736849 PID:1788536; ferredoxin-type protein 1108931 napF 950023 napF Haemophilus influenzae Rd KW20 ferredoxin-type protein NP_439202.1 1108431 R 71421 CDS NP_439203.1 16272976 950592 complement(1108931..1109542) 1 NC_000907.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1109542 950592 HI1044 Haemophilus influenzae Rd KW20 twin-argninine leader-binding protein DmsD NP_439203.1 1108931 R 71421 CDS NP_439204.1 16272977 950571 complement(1109654..1110493) 1 NC_000907.1 similar to GB:J03412 SP:P18777 PID:145757 GB:U00096 PID:1651423; anaerobic dimethyl sulfoxide reductase subunit C 1110493 dmsC 950571 dmsC Haemophilus influenzae Rd KW20 anaerobic dimethyl sulfoxide reductase subunit C NP_439204.1 1109654 R 71421 CDS NP_439205.1 16272978 950772 complement(1110495..1111112) 1 NC_000907.1 similar to GB:J03412 SP:P18776 PID:145756 GB:U00096 PID:1742612; anaerobic dimethyl sulfoxide reductase subunit B 1111112 dmsB 950772 dmsB Haemophilus influenzae Rd KW20 anaerobic dimethyl sulfoxide reductase subunit B NP_439205.1 1110495 R 71421 CDS NP_439206.1 16272979 950024 complement(1111123..1113543) 1 NC_000907.1 similar to GB:J03412 SP:P18775 PID:145755 GB:U00096 PID:1651421; anaerobic dimethyl sulfoxide reductase subunit A 1113543 dmsA 950024 dmsA Haemophilus influenzae Rd KW20 anaerobic dimethyl sulfoxide reductase subunit A NP_439206.1 1111123 R 71421 CDS NP_439207.1 16272980 949536 1113797..1114906 1 NC_000907.1 hypothetical protein 1114906 949536 HI1048 Haemophilus influenzae Rd KW20 hypothetical protein NP_439207.1 1113797 D 71421 CDS NP_439208.1 16272981 949946 1114948..1115241 1 NC_000907.1 similar to SP:P04140 GB:Z00027 PID:154899 PID:43716; mercuric ion transport protein 1115241 merT 949946 merT Haemophilus influenzae Rd KW20 mercuric ion transport protein NP_439208.1 1114948 D 71421 CDS NP_439209.1 16272982 950027 1115250..1115528 1 NC_000907.1 similar to PID:1143574 SP:Q54463; mercuric ion scavenger protein 1115528 merP 950027 merP Haemophilus influenzae Rd KW20 mercuric ion scavenger protein NP_439209.1 1115250 D 71421 CDS NP_439210.1 16272983 950028 complement(1115653..1117497) 1 NC_000907.1 similar to GB:AL009126; ABC transporter ATP-binding protein 1117497 950028 HI1051 Haemophilus influenzae Rd KW20 ABC transporter ATP-binding protein NP_439210.1 1115653 R 71421 CDS NP_439211.1 16272984 950029 complement(1117575..1118471) 1 NC_000907.1 similar to SP:P35319 PID:581707; AraC family transcriptional regulator 1118471 950029 HI1052 Haemophilus influenzae Rd KW20 AraC family transcriptional regulator NP_439211.1 1117575 R 71421 CDS NP_439212.1 16272985 950030 1118583..1118924 1 NC_000907.1 similar to GB:M66060 SP:P27749 PID:141897; hypothetical protein 1118924 950030 HI1053 Haemophilus influenzae Rd KW20 hypothetical protein NP_439212.1 1118583 D 71421 CDS NP_439215.1 16272988 950036 complement(1121801..1123690) 1 NC_000907.1 type III restriction-modification system methyltransferase-like protein 1123690 950036 HI1056 Haemophilus influenzae Rd KW20 type III restriction-modification system methyltransferase-like protein NP_439215.1 1121801 R 71421 CDS NP_439216.1 16272989 949400 complement(1123464..1124048) 1 NC_000907.1 hypothetical protein 1124048 949400 HI1058 Haemophilus influenzae Rd KW20 hypothetical protein NP_439216.1 1123464 R 71421 CDS NP_439217.1 16272990 950033 complement(1124264..1124857) 1 NC_000907.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1124857 rnhB 950033 rnhB Haemophilus influenzae Rd KW20 ribonuclease HII NP_439217.1 1124264 R 71421 CDS NP_439218.1 16272991 950031 complement(1124850..1126022) 1 NC_000907.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 1126022 lpxB 950031 lpxB Haemophilus influenzae Rd KW20 lipid-A-disaccharide synthase NP_439218.1 1124850 R 71421 CDS NP_439219.1 16272992 950038 complement(1126089..1126877) 1 NC_000907.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 1126877 lpxA 950038 lpxA Haemophilus influenzae Rd KW20 UDP-N-acetylglucosamine acyltransferase NP_439219.1 1126089 R 71421 CDS NP_439220.1 16272993 950037 complement(1126891..1127337) 1 NC_000907.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 1127337 fabZ 950037 fabZ Haemophilus influenzae Rd KW20 (3R)-hydroxymyristoyl-ACP dehydratase NP_439220.1 1126891 R 71421 CDS NP_439223.1 16272996 950042 1129110..1129823 1 NC_000907.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 1129823 pyrH 950042 pyrH Haemophilus influenzae Rd KW20 uridylate kinase NP_439223.1 1129110 D 71421 CDS NP_439224.1 16272997 950044 complement(1130062..1131027) 1 NC_000907.1 similar to SP:P32709 GB:X72298 PID:396408 PID:404305 GB:U00096; nitrite reductase transmembrane protein 1131027 nrfD 950044 nrfD Haemophilus influenzae Rd KW20 nitrite reductase transmembrane protein NP_439224.1 1130062 R 71421 CDS NP_439225.1 16272998 950045 complement(1131024..1131701) 1 NC_000907.1 similar to SP:P32708 GB:X72298 PID:396407 PID:404304 GB:U00096; nitrite reductase Fe-S protein 1131701 nrfC 950045 nrfC Haemophilus influenzae Rd KW20 nitrite reductase Fe-S protein NP_439225.1 1131024 R 71421 CDS NP_439226.2 30995421 950046 complement(1131698..1132345) 1 NC_000907.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 1132345 nrfB 950046 nrfB Haemophilus influenzae Rd KW20 cytochrome c nitrite reductase pentaheme subunit NP_439226.2 1131698 R 71421 CDS NP_439227.3 161350017 950047 complement(1132422..1134038) 1 NC_000907.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 1134038 nrfA 950047 nrfA Haemophilus influenzae Rd KW20 cytochrome c552 NP_439227.3 1132422 R 71421 CDS NP_439228.2 161350021 950050 complement(1134200..1138042) 1 NC_000907.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1138042 hrpa 950050 hrpa Haemophilus influenzae Rd KW20 ATP-dependent RNA helicase HrpA NP_439228.2 1134200 R 71421 CDS NP_439229.1 16273002 950051 complement(1138111..1138485) 1 NC_000907.1 similar to SP:P32065 GB:U01030 GB:X73413 PID:312767 PID:523332; hypothetical protein 1138485 950051 HI1073 Haemophilus influenzae Rd KW20 hypothetical protein NP_439229.1 1138111 R 71421 CDS NP_439230.1 16273003 950048 complement(1138486..1138938) 1 NC_000907.1 similar to GB:U00096 PID:1788090; hypothetical protein 1138938 950048 HI1074 Haemophilus influenzae Rd KW20 hypothetical protein NP_439230.1 1138486 R 71421 CDS NP_439231.1 16273004 949877 complement(1139203..1140339) 1 NC_000907.1 similar to GB:J03939 SP:P11027 PID:145640 GB:U00096 PID:1651328; cytochrome oxidase subunit II 1140339 cydB 949877 cydB Haemophilus influenzae Rd KW20 cytochrome oxidase subunit II NP_439231.1 1139203 R 71421 CDS NP_439232.1 16273005 950049 complement(1140354..1141919) 1 NC_000907.1 similar to GB:J03939 SP:P11026 PID:497637 GB:U00096 PID:1651327; cytochrome D ubiquinol oxidase subunit I 1141919 cydA 950049 cydA Haemophilus influenzae Rd KW20 cytochrome D ubiquinol oxidase subunit I NP_439232.1 1140354 R 71421 CDS NP_439233.1 16273006 950052 1142571..1144208 1 NC_000907.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 1144208 pyrG 950052 pyrG Haemophilus influenzae Rd KW20 CTP synthetase NP_439233.1 1142571 D 71421 CDS NP_439235.2 30995423 950054 complement(1145211..1145978) 1 NC_000907.1 similar to SP:P39456; amino-acid ABC transporter ATP-binding protein 1145978 950054 HI1078 Haemophilus influenzae Rd KW20 amino-acid ABC transporter ATP-binding protein NP_439235.2 1145211 R 71421 CDS NP_439236.1 16273641 949554 complement(1145988..1146704) 1 NC_000907.1 amino acid ABC transporter permease 1146704 949554 HI1079m Haemophilus influenzae Rd KW20 amino acid ABC transporter permease NP_439236.1 1145988 R 71421 CDS NP_439237.1 16273008 950096 complement(1146688..1147461) 1 NC_000907.1 similar to SP:P42199; amino acid ABC transporter substrate-binding protein 1147461 950096 HI1080 Haemophilus influenzae Rd KW20 amino acid ABC transporter substrate-binding protein NP_439237.1 1146688 R 71421 CDS NP_439238.1 16273009 950056 complement(1147762..1149036) 1 NC_000907.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1149036 murZ 950056 murZ Haemophilus influenzae Rd KW20 UDP-N-acetylglucosamine 1-carboxyvinyltransferase NP_439238.1 1147762 R 71421 CDS NP_439239.1 16273010 949428 complement(1149047..1149304) 1 NC_000907.1 similar to SP:P43781 PID:606128 GB:U00096 PID:1789581; hypothetical protein 1149304 949428 HI1082 Haemophilus influenzae Rd KW20 hypothetical protein NP_439239.1 1149047 R 71421 CDS NP_439240.1 16273011 950057 complement(1149325..1149642) 1 NC_000907.1 similar to GB:M34995 SP:P17903 GB:L35574 PID:143458 PID:1881281; NTP binding protein 1149642 950057 HI1083 Haemophilus influenzae Rd KW20 NTP binding protein NP_439240.1 1149325 R 71421 CDS NP_439241.1 16273012 950058 complement(1149653..1150297) 1 NC_000907.1 similar to SP:P45390 PID:606130 GB:U00096 PID:1789583; ABC transporter 1150297 950058 HI1084 Haemophilus influenzae Rd KW20 ABC transporter NP_439241.1 1149653 R 71421 CDS NP_439242.1 16273013 950060 complement(1150327..1150830) 1 NC_000907.1 similar to SP:P45391 PID:606131 GB:U00096 PID:1789584; ABC transporter substrate-binding protein 1150830 950060 HI1085 Haemophilus influenzae Rd KW20 ABC transporter substrate-binding protein NP_439242.1 1150327 R 71421 CDS NP_439243.1 16273014 950061 complement(1150841..1151626) 1 NC_000907.1 similar to SP:P45392 PID:606132 GB:U00096 PID:1789585; ABC transporter permease 1151626 950061 HI1086 Haemophilus influenzae Rd KW20 ABC transporter permease NP_439243.1 1150841 R 71421 CDS NP_439244.1 16273015 950090 complement(1151623..1152417) 1 NC_000907.1 similar to SP:P45393 PID:606133 GB:U00096 PID:1789586; ABC transporter ATPase 1152417 950090 HI1087 Haemophilus influenzae Rd KW20 ABC transporter ATPase NP_439244.1 1151623 R 71421 CDS NP_439245.1 16273016 950093 complement(1152847..1153494) 1 NC_000907.1 similar to GB:X73832 PID:1574643; superoxide dismutase 1153494 sodA 950093 sodA Haemophilus influenzae Rd KW20 superoxide dismutase NP_439245.1 1152847 R 71421 CDS NP_439246.1 16273017 949617 1153743..1154381 1 NC_000907.1 ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 1154381 ccmA 949617 ccmA Haemophilus influenzae Rd KW20 cytochrome c biogenesis protein CcmA NP_439246.1 1153743 D 71421 CDS NP_439247.1 16273018 950092 1154386..1155051 1 NC_000907.1 similar to SP:P33930 PID:405925 GB:U00096 PID:1788528; heme exporter protein B 1155051 ccmB 950092 ccmB Haemophilus influenzae Rd KW20 heme exporter protein B NP_439247.1 1154386 D 71421 CDS NP_439248.1 16273019 950063 1155109..1155849 1 NC_000907.1 similar to SP:P33929 PID:405924 GB:U00096 PID:1788527; heme exporter protein C 1155849 ccmC 950063 ccmC Haemophilus influenzae Rd KW20 heme exporter protein C NP_439248.1 1155109 D 71421 CDS NP_439249.1 16273020 950064 1155891..1156094 1 NC_000907.1 similar to SP:P36770 PID:453988 GB:U00096 PID:1788526; heme exporter protein D 1156094 ccmD 950064 ccmD Haemophilus influenzae Rd KW20 heme exporter protein D NP_439249.1 1155891 D 71421 CDS NP_439250.1 16273021 950065 1156091..1156612 1 NC_000907.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 1156612 ccmE 950065 ccmE Haemophilus influenzae Rd KW20 cytochrome c-type biogenesis protein CcmE NP_439250.1 1156091 D 71421 CDS NP_439251.1 16273022 950066 1156609..1158555 1 NC_000907.1 similar to SP:P33927 PID:405921 GB:U00096 PID:1788524; cytochrome C-type biogenesis protein 1158555 ccmF 950066 ccmF Haemophilus influenzae Rd KW20 cytochrome C-type biogenesis protein NP_439251.1 1156609 D 71421 CDS NP_439252.1 16273023 950067 1158694..1159239 1 NC_000907.1 similar to SP:P33926 PID:405920 GB:U00096 PID:1788523; thiol-disulfide interchange protein 1159239 dsbE 950067 dsbE Haemophilus influenzae Rd KW20 thiol-disulfide interchange protein NP_439252.1 1158694 D 71421 CDS NP_439253.1 16273642 950062 1159239..1159700 1 NC_000907.1 cytochrome C-type biogenesis protein 1159700 ccmH 950062 ccmH Haemophilus influenzae Rd KW20 cytochrome C-type biogenesis protein NP_439253.1 1159239 D 71421 CDS NP_439254.1 16273643 950550 1159701..1160618 1 NC_000907.1 hypothetical protein 1160618 950550 HI1097m Haemophilus influenzae Rd KW20 hypothetical protein NP_439254.1 1159701 D 71421 CDS NP_439256.1 16273025 950069 1161239..1161547 1 NC_000907.1 hypothetical protein 1161547 950069 HI1099 Haemophilus influenzae Rd KW20 hypothetical protein NP_439256.1 1161239 D 71421 CDS NP_439257.2 30995424 950070 complement(1161552..1163564) 1 NC_000907.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 1163564 ligA 950070 ligA Haemophilus influenzae Rd KW20 NAD-dependent DNA ligase LigA NP_439257.2 1161552 R 71421 CDS NP_439258.1 16273027 950071 complement(1163676..1164662) 1 NC_000907.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA 1164662 950071 HI1101 Haemophilus influenzae Rd KW20 cell division protein ZipA NP_439258.1 1163676 R 71421 CDS NP_439259.1 16273028 950075 1164815..1165633 1 NC_000907.1 role in sulfur assimilation; sulfate transport protein CysZ 1165633 cysZ 950075 cysZ Haemophilus influenzae Rd KW20 sulfate transport protein CysZ NP_439259.1 1164815 D 71421 CDS NP_439260.1 16273029 950077 1165732..1166682 1 NC_000907.1 similar to GB:M21451 SP:P11096 GB:X12615 PID:145686 PID:41201; cysteine synthetase 1166682 cysK 950077 cysK Haemophilus influenzae Rd KW20 cysteine synthetase NP_439260.1 1165732 D 71421 CDS NP_439261.1 16273030 950078 1167406..1168629 1 NC_000907.1 similar to PID:1842056; transporter protein 1168629 950078 HI1104 Haemophilus influenzae Rd KW20 transporter protein NP_439261.1 1167406 D 71421 CDS NP_439262.1 16273031 950079 complement(1168738..1169778) 1 NC_000907.1 similar to SP:P37692 PID:466758 GB:U00096 PID:1790050; ADP-heptose-LPS heptosyltransferase II 1169778 rfaF 950079 rfaF Haemophilus influenzae Rd KW20 ADP-heptose-LPS heptosyltransferase II NP_439262.1 1168738 R 71421 CDS NP_439263.1 16273032 949767 complement(1169854..1171017) 1 NC_000907.1 similar to SP:P37390 PID:466707 GB:U00096 PID:1789993; xylose operon regulatory protein 1171017 xylR 949767 xylR Haemophilus influenzae Rd KW20 xylose operon regulatory protein NP_439263.1 1169854 R 71421 CDS NP_439264.1 16273033 950734 complement(1171129..1172535) 1 NC_000907.1 similar to GB:U61539 SP:P27611 PID:143245 PID:2209268; Na+/H+ antiporter 1172535 nhaC 950734 nhaC Haemophilus influenzae Rd KW20 Na+/H+ antiporter NP_439264.1 1171129 R 71421 CDS NP_439266.1 16273034 950080 complement(1173984..1175111) 1 NC_000907.1 similar to SP:P37389 PID:466706 GB:U00096 PID:1789992; D-xylose ABC transporter permease 1175111 xylH 950080 xylH Haemophilus influenzae Rd KW20 D-xylose ABC transporter permease NP_439266.1 1173984 R 71421 CDS NP_439267.1 16273035 950081 complement(1175115..1176626) 1 NC_000907.1 with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding protein 1176626 xylG 950081 xylG Haemophilus influenzae Rd KW20 xylose transporter ATP-binding protein NP_439267.1 1175115 R 71421 CDS NP_439268.1 16273036 950082 complement(1176677..1177675) 1 NC_000907.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 1177675 xylF 950082 xylF Haemophilus influenzae Rd KW20 D-xylose transporter subunit XylF NP_439268.1 1176677 R 71421 CDS NP_439269.1 16273037 950068 1177909..1179228 1 NC_000907.1 catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase 1179228 xylA 950068 xylA Haemophilus influenzae Rd KW20 xylose isomerase NP_439269.1 1177909 D 71421 CDS NP_439270.1 16273038 950087 1179231..1180766 1 NC_000907.1 similar to PID:2293419; xylulose kinase 1180766 950087 HI1113 Haemophilus influenzae Rd KW20 xylulose kinase NP_439270.1 1179231 D 71421 CDS NP_439271.1 16273039 950083 complement(1180817..1181743) 1 NC_000907.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-mannoheptose-6-epimerase 1181743 rfaD 950083 rfaD Haemophilus influenzae Rd KW20 ADP-L-glycero-D-mannoheptose-6-epimerase NP_439271.1 1180817 R 71421 CDS NP_439272.1 16273040 950780 complement(1181796..1182299) 1 NC_000907.1 similar to PID:1213065 SP:P52229; thioredoxin 1182299 950780 HI1115 Haemophilus influenzae Rd KW20 thioredoxin NP_439272.1 1181796 R 71421 CDS NP_439273.1 16273041 950311 1182410..1183081 1 NC_000907.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 1183081 deoC 950311 deoC Haemophilus influenzae Rd KW20 deoxyribose-phosphate aldolase NP_439273.1 1182410 D 71421 CDS NP_439274.1 16273042 950645 complement(1183115..1184644) 1 NC_000907.1 similar to GB:M37337 SP:P22787 PID:147774 PID:147775 PID:148173; competence protein 1184644 comM 950645 comM Haemophilus influenzae Rd KW20 competence protein NP_439274.1 1183115 R 71421 CDS NP_439275.1 16273043 950084 complement(1184759..1185376) 1 NC_000907.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 1185376 engB 950084 engB Haemophilus influenzae Rd KW20 ribosome biogenesis GTP-binding protein YsxC NP_439275.1 1184759 R 71421 CDS NP_439276.1 16273044 950085 1185469..1186347 1 NC_000907.1 similar to SP:P32181 GB:M59210 PID:387858; membrane protein 1186347 lapB 950085 lapB Haemophilus influenzae Rd KW20 membrane protein NP_439276.1 1185469 D 71421 CDS NP_439277.1 16273045 950088 complement(1186387..1187385) 1 NC_000907.1 similar to GB:U00096 SP:P77737 PID:1742036 PID:1787500 PID:1805528; oligopeptide ABC transporter ATP-binding protein 1187385 oppF 950088 oppF Haemophilus influenzae Rd KW20 oligopeptide ABC transporter ATP-binding protein NP_439277.1 1186387 R 71421 CDS NP_439278.1 16273046 950089 complement(1187382..1188353) 1 NC_000907.1 similar to SP:P04285 GB:X05491 GB:X52093 PID:47805; oligopeptide transporter ATP-binding protein 1188353 oppD 950089 oppD Haemophilus influenzae Rd KW20 oligopeptide transporter ATP-binding protein NP_439278.1 1187382 R 71421 CDS NP_439279.1 16273047 950091 complement(1188363..1189298) 1 NC_000907.1 similar to SP:P08006 GB:X05491 GB:X52093 PID:47804; oligopeptide ABC transporter permease 1189298 oppC 950091 oppC Haemophilus influenzae Rd KW20 oligopeptide ABC transporter permease NP_439279.1 1188363 R 71421 CDS NP_439280.1 16273048 950094 complement(1189308..1190228) 1 NC_000907.1 similar to GB:U00096 PID:1742033 PID:1787497 PID:1805525; oligopeptide transporter permease 1190228 oppB 950094 oppB Haemophilus influenzae Rd KW20 oligopeptide transporter permease NP_439280.1 1189308 R 71421 CDS NP_439281.1 16273049 950086 complement(1190309..1191934) 1 NC_000907.1 similar to SP:P06202 GB:X05491 GB:X52093 PID:47802 PID:47808; oligopeptide ABC transporter substrate-binding protein 1191934 oppA 950086 oppA Haemophilus influenzae Rd KW20 oligopeptide ABC transporter substrate-binding protein NP_439281.1 1190309 R 71421 CDS NP_439282.1 16273050 950099 1192230..1193183 1 NC_000907.1 Maintains the balance of metabolites in the pentose-phosphate pathway; transaldolase B 1193183 talB 950099 talB Haemophilus influenzae Rd KW20 transaldolase B NP_439282.1 1192230 D 71421 CDS NP_439287.1 16273055 950095 1196050..1196505 1 NC_000907.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 1196505 950095 HI1129 Haemophilus influenzae Rd KW20 cell division protein MraZ NP_439287.1 1196050 D 71421 CDS NP_439288.1 16273056 950097 1196536..1197501 1 NC_000907.1 similar to GB:D10483 SP:P18595 GB:X52063 PID:216497 PID:40850; S-adenosyl-methyltransferase MraW 1197501 mraW 950097 mraW Haemophilus influenzae Rd KW20 S-adenosyl-methyltransferase MraW NP_439288.1 1196536 D 71421 CDS NP_439289.1 16273057 950098 1197504..1197827 1 NC_000907.1 similar to SP:P22187 GB:K00137 GB:S49802 GB:S49875 GB:X52063; cell division protein 1197827 ftsL 950098 ftsL Haemophilus influenzae Rd KW20 cell division protein NP_439289.1 1197504 D 71421 CDS NP_439290.1 16273058 950626 1197840..1199672 1 NC_000907.1 similar to GB:D10483 SP:P04286 GB:K00137 GB:S49802 GB:S49875; penicillin-binding protein 3 1199672 ftsI 950626 ftsI Haemophilus influenzae Rd KW20 penicillin-binding protein 3 NP_439290.1 1197840 D 71421 CDS NP_439291.1 16273059 949983 1199682..1201148 1 NC_000907.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1201148 murE 949983 murE Haemophilus influenzae Rd KW20 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase NP_439291.1 1199682 D 71421 CDS NP_439292.1 16273060 950620 1201162..1202535 1 NC_000907.1 similar to GB:D10483 SP:P11880 PID:216500 PID:40854 PID:42048; UDP-MurNAc-pentapeptide synthetase 1202535 murF 950620 murF Haemophilus influenzae Rd KW20 UDP-MurNAc-pentapeptide synthetase NP_439292.1 1201162 D 71421 CDS NP_439293.1 16273061 950102 1202529..1203611 1 NC_000907.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 1203611 mraY 950102 mraY Haemophilus influenzae Rd KW20 phospho-N-acetylmuramoyl-pentapeptide- transferase NP_439293.1 1202529 D 71421 CDS NP_439294.1 16273062 950103 1203734..1205047 1 NC_000907.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 1205047 murD 950103 murD Haemophilus influenzae Rd KW20 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase NP_439294.1 1203734 D 71421 CDS NP_439295.1 16273063 950104 1205069..1206253 1 NC_000907.1 similar to GB:D10483 SP:P16457 GB:M30807 PID:146039 PID:216503; cell division protein 1206253 ftsW 950104 ftsW Haemophilus influenzae Rd KW20 cell division protein NP_439295.1 1205069 D 71421 CDS NP_439296.1 16273064 949484 1206265..1207320 1 NC_000907.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 1207320 murG 949484 murG Haemophilus influenzae Rd KW20 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase NP_439296.1 1206265 D 71421 CDS NP_439297.1 16273065 949618 1207458..1208885 1 NC_000907.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 1208885 murC 949618 murC Haemophilus influenzae Rd KW20 UDP-N-acetylmuramate--L-alanine ligase NP_439297.1 1207458 D 71421 CDS NP_439298.1 16273066 950555 1208957..1209877 1 NC_000907.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 1209877 ddl 950555 ddl Haemophilus influenzae Rd KW20 D-alanine--D-alanine ligase NP_439298.1 1208957 D 71421 CDS NP_439299.1 16273067 950106 1209877..1210641 1 NC_000907.1 similar to GB:D10483 SP:P06136 GB:K02668 GB:X02821 PID:145725; cell division protein 1210641 ftsQ 950106 ftsQ Haemophilus influenzae Rd KW20 cell division protein NP_439299.1 1209877 D 71421 CDS NP_439300.1 16273068 950107 1210660..1211937 1 NC_000907.1 similar to GB:D10483 SP:P06137 GB:K02668 GB:M36531 GB:X02821; cell division protein 1211937 ftsA 950107 ftsA Haemophilus influenzae Rd KW20 cell division protein NP_439300.1 1210660 D 71421 CDS NP_439301.1 16273069 950290 1212021..1213286 1 NC_000907.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1213286 ftsZ 950290 ftsZ Haemophilus influenzae Rd KW20 cell division protein FtsZ NP_439301.1 1212021 D 71421 CDS NP_439302.1 16273070 950276 1213325..1214242 1 NC_000907.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 1214242 lpxC 950276 lpxC Haemophilus influenzae Rd KW20 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase NP_439302.1 1213325 D 71421 CDS NP_439303.1 16273071 950108 1214369..1215526 1 NC_000907.1 similar to SP:Q02286 GB:M74134 GB:X60420 PID:148468 PID:43344; chorismate mutase/prephenate dehydratase 1215526 pheA 950108 pheA Haemophilus influenzae Rd KW20 chorismate mutase/prephenate dehydratase NP_439303.1 1214369 D 71421 CDS NP_439304.2 30995425 950109 complement(1215571..1216428) 1 NC_000907.1 similar to SP:P33995 GB:Z27094 PID:414888 PID:551341 PID:606144; hypothetical protein 1216428 950109 HI1146 Haemophilus influenzae Rd KW20 hypothetical protein NP_439304.2 1215571 R 71421 CDS NP_439305.1 16273073 950111 complement(1216446..1216940) 1 NC_000907.1 similar to GB:D12938 SP:P31222 GB:Z27094 PID:285783 PID:414887; nitrogen regulatory IIA protein 1216940 ptsN 950111 ptsN Haemophilus influenzae Rd KW20 nitrogen regulatory IIA protein NP_439305.1 1216446 R 71421 CDS NP_439306.1 16273074 950112 complement(1216943..1217668) 1 NC_000907.1 similar to GB:D12938 SP:P31220 PID:285780 PID:551337 PID:606140; ABC transporter ATP-binding protein 1217668 950112 HI1148 Haemophilus influenzae Rd KW20 ABC transporter ATP-binding protein NP_439306.1 1216943 R 71421 CDS NP_439307.1 16273644 950113 complement(1217672..1218190) 1 NC_000907.1 hypothetical protein 1218190 950113 HI1149m Haemophilus influenzae Rd KW20 hypothetical protein NP_439307.1 1217672 R 71421 CDS NP_439308.2 30995426 950694 complement(1218171..1218785) 1 NC_000907.1 similar to SP:P45397 PID:606138 GB:U00096 PID:1789591; hypothetical protein 1218785 950694 HI1150 Haemophilus influenzae Rd KW20 hypothetical protein NP_439308.2 1218171 R 71421 CDS NP_439309.1 16273076 949961 complement(1218836..1219372) 1 NC_000907.1 similar to SP:P26650 GB:M95096 PID:148266 PID:537076 GB:U00096; hypothetical protein 1219372 949961 HI1151 Haemophilus influenzae Rd KW20 hypothetical protein NP_439309.1 1218836 R 71421 CDS NP_439310.1 16273077 950115 1219461..1220816 1 NC_000907.1 similar to SP:P24231 GB:X54152 PID:42440 PID:537077 GB:U00096; hypothetical protein 1220816 pmbA 950115 pmbA Haemophilus influenzae Rd KW20 hypothetical protein NP_439310.1 1219461 D 71421 CDS NP_439311.1 16273078 950117 1221027..1221566 1 NC_000907.1 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase 1221566 hpt 950117 hpt Haemophilus influenzae Rd KW20 hypoxanthine-guanine phosphoribosyltransferase NP_439311.1 1221027 D 71421 CDS NP_439312.1 16273079 950771 1221872..1223194 1 NC_000907.1 similar to GB:U00096 PID:1742823 PID:1742828 PID:1788024; proton glutamate symport protein 1223194 950771 HI1154 Haemophilus influenzae Rd KW20 proton glutamate symport protein NP_439312.1 1221872 D 71421 CDS NP_439313.1 16273080 949759 complement(1223294..1223761) 1 NC_000907.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein 1223761 nrdG 949759 nrdG Haemophilus influenzae Rd KW20 anaerobic ribonucleotide reductase-activating protein NP_439313.1 1223294 R 71421 CDS NP_439314.1 16273081 949498 complement(1224009..1225739) 1 NC_000907.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane protein/ATP-binding protein 1225739 cydC 949498 cydC Haemophilus influenzae Rd KW20 cysteine/glutathione ABC transporter membrane protein/ATP-binding protein NP_439314.1 1224009 R 71421 CDS NP_439315.1 16273082 949785 complement(1225739..1227499) 1 NC_000907.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane protein/ATP-binding protein 1227499 cydD 949785 cydD Haemophilus influenzae Rd KW20 cysteine/glutathione ABC transporter membrane protein/ATP-binding protein NP_439315.1 1225739 R 71421 CDS NP_439316.1 16273083 950118 complement(1227571..1228527) 1 NC_000907.1 similar to GB:J03762 SP:P09625 PID:148073 PID:347239 GB:U00096; thioredoxin reductase 1228527 trxB 950118 trxB Haemophilus influenzae Rd KW20 thioredoxin reductase NP_439316.1 1227571 R 71421 CDS NP_439317.2 30995427 950110 complement(join(1228601..1229386,1229385..1229459)) 1 NC_000907.1 contains frameshifts; thioredoxin domain-containing protein 1229459 950110 HI1159m Haemophilus influenzae Rd KW20 thioredoxin domain-containing protein NP_439317.2 1228601 R 71421 CDS NP_439318.1 16273084 950120 complement(1229539..1230510) 1 NC_000907.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 1230510 hemH 950120 hemH Haemophilus influenzae Rd KW20 ferrochelatase NP_439318.1 1229539 R 71421 CDS NP_439319.1 16273085 950121 complement(1230507..1230923) 1 NC_000907.1 similar to GB:M24143 SP:P15050 PID:450383 PID:522184 GB:U00096; hypothetical protein 1230923 950121 HI1161 Haemophilus influenzae Rd KW20 hypothetical protein NP_439319.1 1230507 R 71421 CDS NP_439320.1 16273086 950122 complement(1231372..1231845) 1 NC_000907.1 similar to SP:P45736 GB:U00096 PID:1279405 PID:1787546; hypothetical protein 1231845 950122 HI1162 Haemophilus influenzae Rd KW20 hypothetical protein NP_439320.1 1231372 R 71421 CDS NP_439321.1 16273087 950119 complement(1231849..1234932) 1 NC_000907.1 similar to GB:U00096 SP:P77748 PID:1742760 PID:1787977; hypothetical protein 1234932 950119 HI1163 Haemophilus influenzae Rd KW20 hypothetical protein NP_439321.1 1231849 R 71421 CDS NP_439322.1 16273088 950124 1235301..1236362 1 NC_000907.1 similar to GB:L20309 SP:P38368; outer membrane protein P5 1236362 ompA 950124 ompA Haemophilus influenzae Rd KW20 outer membrane protein P5 NP_439322.1 1235301 D 71421 CDS NP_439323.2 30995428 949810 1236513..1236836 1 NC_000907.1 similar to PID:2407233; hypothetical protein 1236836 949810 HI1165 Haemophilus influenzae Rd KW20 hypothetical protein NP_439323.2 1236513 D 71421 CDS NP_439324.1 16273090 950769 complement(1236913..1238013) 1 NC_000907.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 1238013 hisH 950769 hisH Haemophilus influenzae Rd KW20 histidinol-phosphate aminotransferase NP_439324.1 1236913 R 71421 CDS NP_439325.1 16273091 949636 complement(1238101..1239189) 1 NC_000907.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 1239189 serC 949636 serC Haemophilus influenzae Rd KW20 phosphoserine aminotransferase NP_439325.1 1238101 R 71421 CDS NP_439326.1 16273092 950127 1239380..1239724 1 NC_000907.1 similar to GB:U00096 PID:1788317; hypothetical protein 1239724 950127 HI1168 Haemophilus influenzae Rd KW20 hypothetical protein NP_439326.1 1239380 D 71421 CDS YP_008530234.1 542123259 16830696 complement(1239765..1240331) 1 NC_000907.1 hypothetical protein 1240331 16830696 HI1168a Haemophilus influenzae Rd KW20 hypothetical protein YP_008530234.1 1239765 R 71421 CDS YP_008530235.1 542123260 950132 complement(1240331..1241317) 1 NC_000907.1 para-aminobenzoate synthase component I 1241317 950132 HI1169 Haemophilus influenzae Rd KW20 para-aminobenzoate synthase component I YP_008530235.1 1240331 R 71421 CDS NP_439329.1 16273095 950129 1241359..1241940 1 NC_000907.1 catalyzes the formation of anthranilate from chorismate and glutamine; functions in tryptophan biosynthesis; anthranilate synthase component II 1241940 trpG 950129 trpG Haemophilus influenzae Rd KW20 anthranilate synthase component II NP_439329.1 1241359 D 71421 CDS NP_439330.1 16273096 950016 1242025..1243179 1 NC_000907.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1243179 metX 950016 metX Haemophilus influenzae Rd KW20 S-adenosylmethionine synthetase NP_439330.1 1242025 D 71421 CDS NP_439331.1 16273097 950125 1243518..1243988 1 NC_000907.1 similar to SP:P39902 PID:1208420 PID:882473 GB:U00096 PID:1789313; hypothetical protein 1243988 sprT 950125 sprT Haemophilus influenzae Rd KW20 hypothetical protein NP_439331.1 1243518 D 71421 CDS NP_439332.2 30995429 950130 1244067..1244552 1 NC_000907.1 similar to GB:X15780 PID:1333789; opacity protein 1244552 950130 HI1174 Haemophilus influenzae Rd KW20 opacity protein NP_439332.2 1244067 D 71421 CDS NP_439333.1 16273099 950131 complement(1245169..1245852) 1 NC_000907.1 with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM 1245852 artM 950131 artM Haemophilus influenzae Rd KW20 arginine transporter permease subunit ArtM NP_439333.1 1245169 R 71421 CDS NP_439334.1 16273100 950141 complement(1245852..1246517) 1 NC_000907.1 with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ 1246517 artQ 950141 artQ Haemophilus influenzae Rd KW20 arginine transporter permease subunit ArtQ NP_439334.1 1245852 R 71421 CDS NP_439335.1 16273101 950269 complement(1246521..1247240) 1 NC_000907.1 similar to GB:M59210 SP:P49618 PID:387859; arginine ABC transporter substrate-binding protein 1247240 artI 950269 artI Haemophilus influenzae Rd KW20 arginine ABC transporter substrate-binding protein NP_439335.1 1246521 R 71421 CDS NP_439336.1 16273102 950628 complement(1247258..1247989) 1 NC_000907.1 With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding protein 1247989 artP 950628 artP Haemophilus influenzae Rd KW20 arginine transporter ATP-binding protein NP_439336.1 1247258 R 71421 CDS NP_439337.1 16273103 950026 complement(1248116..1248700) 1 NC_000907.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 1248700 gmhA 950026 gmhA Haemophilus influenzae Rd KW20 phosphoheptose isomerase NP_439337.1 1248116 R 71421 CDS NP_439340.1 16273106 950622 complement(1249741..1250724) 1 NC_000907.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding protein 1250724 dppF 950622 dppF Haemophilus influenzae Rd KW20 dipeptide transporter ATP-binding protein NP_439340.1 1249741 R 71421 CDS NP_439341.1 16273107 950137 complement(1250727..1251719) 1 NC_000907.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding protein 1251719 dppD 950137 dppD Haemophilus influenzae Rd KW20 dipeptide transporter ATP-binding protein NP_439341.1 1250727 R 71421 CDS NP_439342.1 16273108 950114 complement(1251729..1252616) 1 NC_000907.1 similar to SP:P37315 PID:349227 PID:466681 GB:U00096 PID:1789964; dipeptide ABC transporter permease 1252616 dppC 950114 dppC Haemophilus influenzae Rd KW20 dipeptide ABC transporter permease NP_439342.1 1251729 R 71421 CDS NP_439343.2 30995430 950100 complement(1252631..1253602) 1 NC_000907.1 similar to SP:P37316 PID:349226 PID:466682 GB:U00096 PID:1789965; dipeptide ABC transporter permease 1253602 dppB 950100 dppB Haemophilus influenzae Rd KW20 dipeptide ABC transporter permease NP_439343.2 1252631 R 71421 CDS NP_439344.1 16273110 950076 complement(1253722..1255905) 1 NC_000907.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 1255905 uvrD 950076 uvrD Haemophilus influenzae Rd KW20 DNA-dependent helicase II NP_439344.1 1253722 R 71421 CDS NP_439345.1 16273111 950138 complement(1256516..1257151) 1 NC_000907.1 similar to PID:1652793; hypothetical protein 1257151 950138 HI1189 Haemophilus influenzae Rd KW20 hypothetical protein NP_439345.1 1256516 R 71421 CDS NP_439346.1 16273112 950142 complement(1257152..1257577) 1 NC_000907.1 similar to PID:882658 GB:U00096 SP:Q46903 PID:1789124; 6-pyruvoyl tetrahydrobiopterin synthase 1257577 950142 HI1190 Haemophilus influenzae Rd KW20 6-pyruvoyl tetrahydrobiopterin synthase NP_439346.1 1257152 R 71421 CDS NP_439348.1 16273114 950139 1258413..1258556 1 NC_000907.1 hypothetical protein 1258556 950139 HI1192 Haemophilus influenzae Rd KW20 hypothetical protein NP_439348.1 1258413 D 71421 CDS NP_439349.1 16273115 950143 complement(1258603..1259634) 1 NC_000907.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 1259634 ilvE 950143 ilvE Haemophilus influenzae Rd KW20 branched-chain amino acid aminotransferase NP_439349.1 1258603 R 71421 CDS NP_439350.1 16273646 950145 1260108..1261001 1 NC_000907.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA 1261001 gcvA 950145 gcvA Haemophilus influenzae Rd KW20 DNA-binding transcriptional activator GcvA NP_439350.1 1260108 D 71421 CDS NP_439351.1 16273647 950147 1260994..1262085 1 NC_000907.1 RNA 2'-O-ribose methyltransferase 1262085 950147 HI1195m Haemophilus influenzae Rd KW20 RNA 2'-O-ribose methyltransferase NP_439351.1 1260994 D 71421 CDS NP_439352.1 16273116 950149 1262121..1263290 1 NC_000907.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 1263290 sucC 950149 sucC Haemophilus influenzae Rd KW20 succinyl-CoA synthetase subunit beta NP_439352.1 1262121 D 71421 CDS NP_439353.1 16273117 950515 1263290..1264171 1 NC_000907.1 similar to GB:J01619 SP:P07459 PID:146204 PID:809679 GB:U00096; succinyl-CoA synthetase subunit alpha 1264171 sucD 950515 sucD Haemophilus influenzae Rd KW20 succinyl-CoA synthetase subunit alpha NP_439353.1 1263290 D 71421 CDS NP_439354.1 16273118 950741 1264292..1264915 1 NC_000907.1 similar to SP:P45847 PID:602960 GB:U00096 PID:1787521; hypothetical protein 1264915 950741 HI1198 Haemophilus influenzae Rd KW20 hypothetical protein NP_439354.1 1264292 D 71421 CDS NP_439355.1 16273119 950150 1264963..1266036 1 NC_000907.1 similar to PID:602963 GB:U00096 PID:1787524; hypothetical protein 1266036 950150 HI1199 Haemophilus influenzae Rd KW20 hypothetical protein NP_439355.1 1264963 D 71421 CDS NP_439356.1 16273120 950152 1266047..1267018 1 NC_000907.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1267018 cysB 950152 cysB Haemophilus influenzae Rd KW20 transcriptional regulator CysB NP_439356.1 1266047 D 71421 CDS NP_439357.1 16273121 950156 complement(1267077..1268021) 1 NC_000907.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1268021 950156 HI1201 Haemophilus influenzae Rd KW20 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase NP_439357.1 1267077 R 71421 CDS NP_439358.2 30995431 950140 1268132..1268656 1 NC_000907.1 similar to GB:U00096 PID:1788671; hypothetical protein 1268656 950140 HI1202 Haemophilus influenzae Rd KW20 hypothetical protein NP_439358.2 1268132 D 71421 CDS NP_439359.1 16273123 950151 complement(1268731..1270866) 1 NC_000907.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 1270866 pta 950151 pta Haemophilus influenzae Rd KW20 phosphate acetyltransferase NP_439359.1 1268731 R 71421 CDS NP_439360.1 16273124 949638 complement(1270934..1272139) 1 NC_000907.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 1272139 ackA 949638 ackA Haemophilus influenzae Rd KW20 acetate kinase NP_439360.1 1270934 R 71421 CDS NP_439361.1 16273125 950166 1272354..1272797 1 NC_000907.1 similar to GB:U00096 PID:1788632 GB:U00096 PID:1788632; hypothetical protein 1272797 950166 HI1205 Haemophilus influenzae Rd KW20 hypothetical protein NP_439361.1 1272354 D 71421 CDS NP_439362.1 16273126 950153 1272884..1273375 1 NC_000907.1 similar to GB:J01666 SP:P08550 PID:146367 PID:147415 GB:U00096; colicin V production protein 1273375 cvpA 950153 cvpA Haemophilus influenzae Rd KW20 colicin V production protein NP_439362.1 1272884 D 71421 CDS NP_439363.1 16273127 950171 1273386..1274903 1 NC_000907.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 1274903 purF 950171 purF Haemophilus influenzae Rd KW20 amidophosphoribosyltransferase NP_439363.1 1273386 D 71421 CDS NP_439364.1 16273128 950157 complement(1274958..1275848) 1 NC_000907.1 similar to GB:L42023 PID:1007092 PID:1221333 PID:1205451 PID:1574138; hypothetical protein 1275848 950157 HI1208 Haemophilus influenzae Rd KW20 hypothetical protein NP_439364.1 1274958 R 71421 CDS NP_439365.1 16273129 950154 complement(1275848..1276303) 1 NC_000907.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 1276303 argR 950154 argR Haemophilus influenzae Rd KW20 arginine repressor NP_439365.1 1275848 R 71421 CDS NP_439366.1 16273130 950148 1276510..1277445 1 NC_000907.1 oxidizes malate to oxaloacetate; malate dehydrogenase 1277445 mdh 950148 mdh Haemophilus influenzae Rd KW20 malate dehydrogenase NP_439366.1 1276510 D 71421 CDS NP_439367.1 16273131 950158 complement(1277530..1279038) 1 NC_000907.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 1279038 lysS 950158 lysS Haemophilus influenzae Rd KW20 lysyl-tRNA synthetase NP_439367.1 1277530 R 71421 CDS YP_008530236.1 542123261 950159 complement(1279189..1279935) 1 NC_000907.1 peptide chain release factor 1 1279935 950159 HI1212 Haemophilus influenzae Rd KW20 peptide chain release factor 1 YP_008530236.1 1279189 R 71421 CDS NP_439369.1 16273132 950655 1280420..1281109 1 NC_000907.1 similar to GB:M54884 SP:P21892 PID:147549 PID:887843 GB:U00096; thiol-disulfide interchange protein 1281109 dsbC 950655 dsbC Haemophilus influenzae Rd KW20 thiol-disulfide interchange protein NP_439369.1 1280420 D 71421 CDS NP_439370.1 16273133 950889 1281398..1283125 1 NC_000907.1 similar to GB:M54884 SP:P21893 PID:147550 PID:887842 GB:U00096; single-stranded-DNA-specific exonuclease 1283125 recJ 950889 recJ Haemophilus influenzae Rd KW20 single-stranded-DNA-specific exonuclease NP_439370.1 1281398 D 71421 CDS NP_439371.2 30995432 950165 1283130..1283825 1 NC_000907.1 similar to PID:840949 SP:P50024; thiol-disulfide interchange protein 1283825 dsbA 950165 dsbA Haemophilus influenzae Rd KW20 thiol-disulfide interchange protein NP_439371.2 1283130 D 71421 CDS NP_439372.1 16273135 950160 1283822..1284511 1 NC_000907.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1284511 pfs 950160 pfs Haemophilus influenzae Rd KW20 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase NP_439372.1 1283822 D 71421 CDS NP_439373.1 16273136 950767 complement(1284588..1287329) 1 NC_000907.1 similar to PID:2764817; transferrin-binding protein 1287329 950767 HI1217 Haemophilus influenzae Rd KW20 transferrin-binding protein NP_439373.1 1284588 R 71421 CDS NP_439374.1 16273137 950748 complement(1287584..1289182) 1 NC_000907.1 similar to GB:AE000782; L-lactate permease 1289182 lctP 950748 lctP Haemophilus influenzae Rd KW20 L-lactate permease NP_439374.1 1287584 R 71421 CDS NP_439375.2 30995433 950461 1289456..1290157 1 NC_000907.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1290157 cmk 950461 cmk Haemophilus influenzae Rd KW20 cytidylate kinase NP_439375.2 1289456 D 71421 CDS NP_439376.1 16273139 950163 1290233..1291882 1 NC_000907.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1291882 rpsA 950163 rpsA Haemophilus influenzae Rd KW20 30S ribosomal protein S1 NP_439376.1 1290233 D 71421 CDS NP_439377.1 16273140 950562 1292005..1292289 1 NC_000907.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 1292289 ihfB 950562 ihfB Haemophilus influenzae Rd KW20 integration host factor subunit beta NP_439377.1 1292005 D 71421 CDS NP_439378.1 16273141 950617 1292364..1292657 1 NC_000907.1 similar to GB:U00096 PID:1787535; hypothetical protein 1292657 950617 HI1222 Haemophilus influenzae Rd KW20 hypothetical protein NP_439378.1 1292364 D 71421 CDS NP_439379.1 16273142 950168 1292657..1293847 1 NC_000907.1 similar to SP:P45576 GB:U00096 PID:2367116; hypothetical protein 1293847 950168 HI1223 Haemophilus influenzae Rd KW20 hypothetical protein NP_439379.1 1292657 D 71421 CDS NP_439380.1 16273143 950791 1293871..1294563 1 NC_000907.1 OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1294563 pyrF 950791 pyrF Haemophilus influenzae Rd KW20 orotidine 5'-phosphate decarboxylase NP_439380.1 1293871 D 71421 CDS NP_439381.1 16273144 950401 1294570..1294890 1 NC_000907.1 involved in start site selection during the initiation of translation; translation initiation factor Sui1 1294890 950401 HI1225 Haemophilus influenzae Rd KW20 translation initiation factor Sui1 NP_439381.1 1294570 D 71421 CDS NP_439382.1 16273145 950792 complement(1294919..1295614) 1 NC_000907.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor 1295614 950792 HI1225.1 Haemophilus influenzae Rd KW20 DNA replication initiation factor NP_439382.1 1294919 R 71421 CDS NP_439383.1 16273146 950172 complement(1295680..1296924) 1 NC_000907.1 similar to GB:X76083 SP:P41006 PID:431231; uracil permease 1296924 uraA 950172 uraA Haemophilus influenzae Rd KW20 uracil permease NP_439383.1 1295680 R 71421 CDS NP_439384.1 16273147 950169 complement(1297029..1297655) 1 NC_000907.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 1297655 upp 950169 upp Haemophilus influenzae Rd KW20 uracil phosphoribosyltransferase NP_439384.1 1297029 R 71421 CDS NP_439385.1 16273148 950174 complement(1297779..1299845) 1 NC_000907.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 1299845 dnaX 950174 dnaX Haemophilus influenzae Rd KW20 DNA polymerase III subunits gamma and tau NP_439385.1 1297779 R 71421 CDS NP_439386.1 16273149 950707 complement(1299857..1300399) 1 NC_000907.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 1300399 apt 950707 apt Haemophilus influenzae Rd KW20 adenine phosphoribosyltransferase NP_439386.1 1299857 R 71421 CDS NP_439387.1 16273150 950173 complement(1300547..1301983) 1 NC_000907.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 1301983 lpdA 950173 lpdA Haemophilus influenzae Rd KW20 dihydrolipoamide dehydrogenase NP_439387.1 1300547 R 71421 CDS NP_439388.1 16273151 949836 complement(1302097..1303800) 1 NC_000907.1 similar to GB:D26562 SP:P06959 GB:V01498 PID:434011 PID:473784; dihydrolipoamide acetyltransferase 1303800 aceF 949836 aceF Haemophilus influenzae Rd KW20 dihydrolipoamide acetyltransferase NP_439388.1 1302097 R 71421 CDS NP_439389.1 16273152 950116 complement(1303863..1306523) 1 NC_000907.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 1306523 aceE 950116 aceE Haemophilus influenzae Rd KW20 pyruvate dehydrogenase subunit E1 NP_439389.1 1303863 R 71421 CDS NP_439390.1 16273153 950176 1306823..1307281 1 NC_000907.1 catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 1307281 mgsA 950176 mgsA Haemophilus influenzae Rd KW20 methylglyoxal synthase NP_439390.1 1306823 D 71421 CDS NP_439393.1 16273156 950188 1309144..1311051 1 NC_000907.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 1311051 dnaK 950188 dnaK Haemophilus influenzae Rd KW20 molecular chaperone DnaK NP_439393.1 1309144 D 71421 CDS NP_439394.1 16273157 950178 1311102..1312286 1 NC_000907.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 1312286 dnaJ 950178 dnaJ Haemophilus influenzae Rd KW20 chaperone protein DnaJ NP_439394.1 1311102 D 71421 CDS NP_439395.1 16273158 950691 complement(1312365..1313618) 1 NC_000907.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 1313618 proA 950691 proA Haemophilus influenzae Rd KW20 gamma-glutamyl phosphate reductase NP_439395.1 1312365 R 71421 CDS NP_439396.1 16273159 950105 complement(1313639..1314301) 1 NC_000907.1 similar to GB:L10328 SP:P31432 PID:290496 GB:U00096 PID:1790078; hypothetical protein 1314301 950105 HI1240 Haemophilus influenzae Rd KW20 hypothetical protein NP_439396.1 1313639 R 71421 CDS NP_439397.1 16273160 950179 1314399..1315199 1 NC_000907.1 hypothetical protein 1315199 950179 HI1241 Haemophilus influenzae Rd KW20 hypothetical protein NP_439397.1 1314399 D 71421 CDS NP_439398.1 16273161 949578 complement(1315231..1316427) 1 NC_000907.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system 1316427 bcr 949578 bcr Haemophilus influenzae Rd KW20 bicyclomycin/multidrug efflux system NP_439398.1 1315231 R 71421 CDS NP_439399.1 16273162 950576 complement(1316429..1317127) 1 NC_000907.1 similar to SP:P33918 PID:405907 GB:U00096 PID:1788510; 16S pseudouridylate 516 synthase 1317127 rsuA 950576 rsuA Haemophilus influenzae Rd KW20 16S pseudouridylate 516 synthase NP_439399.1 1316429 R 71421 CDS NP_439400.1 16273163 950183 complement(1317218..1317838) 1 NC_000907.1 hypothetical protein 1317838 950183 HI1244 Haemophilus influenzae Rd KW20 hypothetical protein NP_439400.1 1317218 R 71421 CDS NP_439401.1 16273164 949562 1318036..1320306 1 NC_000907.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 1320306 949562 HI1245 Haemophilus influenzae Rd KW20 malic enzyme NP_439401.1 1318036 D 71421 CDS NP_439402.1 16273165 950184 1320516..1322459 1 NC_000907.1 hypothetical protein 1322459 950184 HI1246 Haemophilus influenzae Rd KW20 hypothetical protein NP_439402.1 1320516 D 71421 CDS NP_439403.1 16273166 950196 complement(1322490..1324529) 1 NC_000907.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1324529 uvrB 950196 uvrB Haemophilus influenzae Rd KW20 excinuclease ABC subunit B NP_439403.1 1322490 R 71421 CDS NP_439404.1 16273167 950186 complement(1325143..1326111) 1 NC_000907.1 hypothetical protein 1326111 950186 HI1248 Haemophilus influenzae Rd KW20 hypothetical protein NP_439404.1 1325143 R 71421 CDS NP_439405.1 16273168 950126 complement(1326114..1326734) 1 NC_000907.1 hypothetical protein 1326734 950126 HI1249 Haemophilus influenzae Rd KW20 hypothetical protein NP_439405.1 1326114 R 71421 CDS NP_439406.1 16273169 950243 1327059..1327364 1 NC_000907.1 hypothetical protein 1327364 950243 HI1250 Haemophilus influenzae Rd KW20 hypothetical protein NP_439406.1 1327059 D 71421 CDS NP_439407.1 16273170 950190 1327375..1327698 1 NC_000907.1 similar to PID:1002991 PID:563265 SP:Q46560; virulence-associated protein A 1327698 vapA 950190 vapA Haemophilus influenzae Rd KW20 virulence-associated protein A NP_439407.1 1327375 D 71421 CDS NP_439408.1 16273171 950263 1327861..1329531 1 NC_000907.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 1329531 950263 HI1252 Haemophilus influenzae Rd KW20 ABC transporter ATP-binding protein NP_439408.1 1327861 D 71421 CDS NP_439409.1 16273172 950692 1329551..1329934 1 NC_000907.1 similar to PID:968932 GB:U00096 PID:1787464; hypothetical protein 1329934 950692 HI1253 Haemophilus influenzae Rd KW20 hypothetical protein NP_439409.1 1329551 D 71421 CDS NP_439413.1 16273176 950181 1332180..1335620 1 NC_000907.1 similar to SP:P30958 GB:U00096 PID:1651547 PID:1651549 PID:1787357; transcription-repair coupling factor 1335620 mfd 950181 mfd Haemophilus influenzae Rd KW20 transcription-repair coupling factor NP_439413.1 1332180 D 71421 CDS NP_439414.1 16273177 950193 complement(1335673..1337073) 1 NC_000907.1 similar to SP:P39099 PID:558912 PID:606173 PID:984379 GB:U00096; serine protease 1337073 950193 HI1259 Haemophilus influenzae Rd KW20 serine protease NP_439414.1 1335673 R 71421 CDS NP_439415.1 16273178 950194 1337267..1338157 1 NC_000907.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 1338157 accD 950194 accD Haemophilus influenzae Rd KW20 acetyl-CoA carboxylase subunit beta NP_439415.1 1337267 D 71421 CDS NP_439416.1 16273179 950205 1338150..1339463 1 NC_000907.1 similar to GB:M68934 SP:P08192 GB:M32445 PID:146009 PID:146020; folylpolyglutamate synthase/dihydrofolate synthase 1339463 folC 950205 folC Haemophilus influenzae Rd KW20 folylpolyglutamate synthase/dihydrofolate synthase NP_439416.1 1338150 D 71421 CDS NP_439417.2 30995434 950206 complement(1339751..1340431) 1 NC_000907.1 similar to SP:P33017 PID:405877 PID:1161522 GB:U00096 PID:1788466; hypothetical protein 1340431 sanA 950206 sanA Haemophilus influenzae Rd KW20 hypothetical protein NP_439417.2 1339751 R 71421 CDS NP_439418.1 16273181 950208 1340589..1341665 1 NC_000907.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase 1341665 metX 950208 metX Haemophilus influenzae Rd KW20 homoserine O-acetyltransferase NP_439418.1 1340589 D 71421 CDS NP_439419.1 16273182 950199 complement(1341719..1344361) 1 NC_000907.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 1344361 gyrA 950199 gyrA Haemophilus influenzae Rd KW20 DNA gyrase subunit A NP_439419.1 1341719 R 71421 CDS NP_439420.1 16273183 950187 complement(1344944..1346707) 1 NC_000907.1 similar to GB:U00096 SP:P75838 PID:1787133; hypothetical protein 1346707 950187 HI1265 Haemophilus influenzae Rd KW20 hypothetical protein NP_439420.1 1344944 R 71421 CDS NP_439421.1 16273184 950198 complement(1346844..1347230) 1 NC_000907.1 hypothetical protein 1347230 950198 HI1266 Haemophilus influenzae Rd KW20 hypothetical protein NP_439421.1 1346844 R 71421 CDS NP_439425.1 16273187 950689 1348468..1349259 1 NC_000907.1 similar to GB:AE000511 SP:O05732 PID:2072456 PID:2314024; ABC transporter ATP-binding protein 1349259 950689 HI1272 Haemophilus influenzae Rd KW20 ABC transporter ATP-binding protein NP_439425.1 1348468 D 71421 CDS NP_439426.1 16273188 950164 1349256..1350062 1 NC_000907.1 similar to PID:1816658; hypothetical protein 1350062 950164 HI1273 Haemophilus influenzae Rd KW20 hypothetical protein NP_439426.1 1349256 D 71421 CDS NP_439427.1 16273189 950207 1350114..1350830 1 NC_000907.1 similar to PID:1208973 GB:U00096 SP:Q47677 PID:1552782 PID:1786406; hydroxyacylglutathione hydrolase 1350830 950207 HI1274 Haemophilus influenzae Rd KW20 hydroxyacylglutathione hydrolase NP_439427.1 1350114 D 71421 CDS NP_439428.1 16273190 949980 complement(1350886..1351746) 1 NC_000907.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 1351746 tehB 949980 tehB Haemophilus influenzae Rd KW20 tellurite resistance protein TehB NP_439428.1 1350886 R 71421 CDS NP_439429.1 16273191 949809 complement(1351859..1353907) 1 NC_000907.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 1353907 metG 949809 metG Haemophilus influenzae Rd KW20 methionyl-tRNA synthetase NP_439429.1 1351859 R 71421 CDS NP_439430.2 30995435 950197 1354058..1355170 1 NC_000907.1 similar to SP:P21590 GB:U00007 GB:X55791 PID:405896 PID:42017; ATPase 1355170 mrp 950197 mrp Haemophilus influenzae Rd KW20 ATPase NP_439430.2 1354058 D 71421 CDS NP_439431.1 16273193 950210 complement(1355217..1355879) 1 NC_000907.1 similar to GB:D17743 SP:P46072 PID:517169; NAD(P)H-flavin oxidoreductase 1355879 950210 HI1278 Haemophilus influenzae Rd KW20 NAD(P)H-flavin oxidoreductase NP_439431.1 1355217 R 71421 CDS NP_439432.1 16273194 950022 1355984..1356670 1 NC_000907.1 similar to GB:M95053 GB:X78068 GB:U04328 PID:460146 PID:520734; acylneuraminate cytidylyltransferase 1356670 neuA 950022 neuA Haemophilus influenzae Rd KW20 acylneuraminate cytidylyltransferase NP_439432.1 1355984 D 71421 CDS NP_439434.2 30995436 950221 1358656..1359111 1 NC_000907.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 1359111 950221 HI1282 Haemophilus influenzae Rd KW20 hypothetical protein NP_439434.2 1358656 D 71421 CDS NP_439435.1 16273197 950214 1359128..1360615 1 NC_000907.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 1360615 nusA 950214 nusA Haemophilus influenzae Rd KW20 transcription elongation factor NusA NP_439435.1 1359128 D 71421 CDS NP_439436.1 16273198 950215 1360627..1363116 1 NC_000907.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 1363116 infB 950215 infB Haemophilus influenzae Rd KW20 translation initiation factor IF-2 NP_439436.1 1360627 D 71421 CDS NP_439437.1 16273199 950228 complement(1363195..1366362) 1 NC_000907.1 similar to PID:1685100; type I restriction enzyme 1366362 hsdR 950228 hsdR Haemophilus influenzae Rd KW20 type I restriction enzyme NP_439437.1 1363195 R 71421 CDS NP_439438.1 16273200 950231 complement(1366454..1367833) 1 NC_000907.1 similar to PID:1685099; type I restriction/modification specificity protein 1367833 hsdS 950231 hsdS Haemophilus influenzae Rd KW20 type I restriction/modification specificity protein NP_439438.1 1366454 R 71421 CDS NP_439439.2 30995437 950217 complement(1367826..1369556) 1 NC_000907.1 similar to PID:1679866; type I modification enzyme 1369556 hsdM 950217 hsdM Haemophilus influenzae Rd KW20 type I modification enzyme NP_439439.2 1367826 R 71421 CDS NP_439440.1 16273202 950218 1369672..1370058 1 NC_000907.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 1370058 rbfA 950218 rbfA Haemophilus influenzae Rd KW20 ribosome-binding factor A NP_439440.1 1369672 D 71421 CDS NP_439441.1 16273203 950222 1370058..1370996 1 NC_000907.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 1370996 truB 950222 truB Haemophilus influenzae Rd KW20 tRNA pseudouridine synthase B NP_439441.1 1370058 D 71421 CDS NP_439442.1 16273204 950220 1371056..1372189 1 NC_000907.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 1372189 tyrA 950220 tyrA Haemophilus influenzae Rd KW20 bifunctional chorismate mutase/prephenate dehydrogenase NP_439442.1 1371056 D 71421 CDS NP_439443.1 16273205 949405 complement(1372222..1373061) 1 NC_000907.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 1373061 queF 949405 queF Haemophilus influenzae Rd KW20 7-cyano-7-deazaguanine reductase NP_439443.1 1372222 R 71421 CDS NP_439444.1 16273206 949593 complement(1373188..1373973) 1 NC_000907.1 hypothetical protein 1373973 949593 HI1292 Haemophilus influenzae Rd KW20 hypothetical protein NP_439444.1 1373188 R 71421 CDS NP_439445.1 16273207 950226 complement(1373964..1374344) 1 NC_000907.1 similar to PID:882706 GB:U00096 SP:Q46926 PID:1789176; hypothetical protein 1374344 950226 HI1293 Haemophilus influenzae Rd KW20 hypothetical protein NP_439445.1 1373964 R 71421 CDS NP_439446.2 30995438 950232 complement(1374341..1375534) 1 NC_000907.1 similar to PID:882705 GB:U00096 PID:1789175; selenocysteine lyase 1375534 950232 HI1295 Haemophilus influenzae Rd KW20 selenocysteine lyase NP_439446.2 1374341 R 71421 CDS NP_439447.2 30995439 950236 complement(1375488..1376003) 1 NC_000907.1 similar to SP:P29769; nuclease 1376003 950236 HI1296 Haemophilus influenzae Rd KW20 nuclease NP_439447.2 1375488 R 71421 CDS NP_439448.1 16273210 950233 1376139..1376561 1 NC_000907.1 similar to SP:P33372 PID:405872 GB:U00096 PID:1788463; hypothetical protein 1376561 950233 HI1297 Haemophilus influenzae Rd KW20 hypothetical protein NP_439448.1 1376139 D 71421 CDS NP_439449.1 16273211 950227 1376580..1377275 1 NC_000907.1 similar to SP:P33373 PID:405873 GB:U00096 PID:1788464; hypothetical protein 1377275 950227 HI1298 Haemophilus influenzae Rd KW20 hypothetical protein NP_439449.1 1376580 D 71421 CDS NP_439451.1 16273212 950128 1378846..1380789 1 NC_000907.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 1380789 950128 HI1300 Haemophilus influenzae Rd KW20 ABC transporter ATPase NP_439451.1 1378846 D 71421 CDS NP_439452.1 16273213 950229 complement(1380817..1381506) 1 NC_000907.1 similar to PID:1513236; carbonic anhydrase 1381506 950229 HI1301 Haemophilus influenzae Rd KW20 carbonic anhydrase NP_439452.1 1380817 R 71421 CDS NP_439453.2 30995440 950195 complement(1381582..1382985) 1 NC_000907.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 1382985 asnC 950195 asnC Haemophilus influenzae Rd KW20 asparaginyl-tRNA synthetase NP_439453.2 1381582 R 71421 CDS NP_439454.2 30995441 949500 1383211..1383684 1 NC_000907.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 1383684 ribH 949500 ribH Haemophilus influenzae Rd KW20 6,7-dimethyl-8-ribityllumazine synthase NP_439454.2 1383211 D 71421 CDS NP_439455.1 16273216 950225 1383688..1384122 1 NC_000907.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 1384122 nusB 950225 nusB Haemophilus influenzae Rd KW20 transcription antitermination protein NusB NP_439455.1 1383688 D 71421 CDS NP_439456.1 16273217 950230 1384139..1385176 1 NC_000907.1 similar to GB:U00096 SP:P77785 PID:1773101 PID:1786619 PID:2329840; thiamin-monophosphate kinase 1385176 thiL 950230 thiL Haemophilus influenzae Rd KW20 thiamin-monophosphate kinase NP_439456.1 1384139 D 71421 CDS NP_439457.1 16273218 950237 1385173..1385664 1 NC_000907.1 similar to GB:U00096 PID:1773102 PID:1786620 PID:2329841; phosphatidylglycerophosphatase A 1385664 pgpA 950237 pgpA Haemophilus influenzae Rd KW20 phosphatidylglycerophosphatase A NP_439457.1 1385173 D 71421 CDS NP_439458.1 16273219 950239 1385661..1386293 1 NC_000907.1 similar to GB:U00096 SP:P75693 PID:1657525 PID:1786522; hypothetical protein 1386293 950239 HI1307 Haemophilus influenzae Rd KW20 hypothetical protein NP_439458.1 1385661 D 71421 CDS NP_439459.1 16273220 950240 1386310..1387122 1 NC_000907.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 1387122 dapB 950240 dapB Haemophilus influenzae Rd KW20 dihydrodipicolinate reductase NP_439459.1 1386310 D 71421 CDS NP_439460.1 16273221 950234 complement(1387117..1387365) 1 NC_000907.1 similar to SP:P37910 GB:U00096 PID:1788568; hypothetical protein 1387365 950234 HI1309 Haemophilus influenzae Rd KW20 hypothetical protein NP_439460.1 1387117 R 71421 CDS NP_439461.1 16273222 949509 1387390..1388151 1 NC_000907.1 hypothetical protein 1388151 949509 HI1310 Haemophilus influenzae Rd KW20 hypothetical protein NP_439461.1 1387390 D 71421 CDS NP_439462.1 16273223 950073 1388300..1389289 1 NC_000907.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1389289 pheS 950073 pheS Haemophilus influenzae Rd KW20 phenylalanyl-tRNA synthetase subunit alpha NP_439462.1 1388300 D 71421 CDS NP_439463.1 16273224 950235 1389323..1391710 1 NC_000907.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1391710 pheT 950235 pheT Haemophilus influenzae Rd KW20 phenylalanyl-tRNA synthetase subunit beta NP_439463.1 1389323 D 71421 CDS NP_439464.1 16273225 949629 1391712..1392002 1 NC_000907.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 1392002 ihfA 949629 ihfA Haemophilus influenzae Rd KW20 integration host factor subunit alpha NP_439464.1 1391712 D 71421 CDS NP_439465.1 16273226 949594 1392055..1392540 1 NC_000907.1 similar to GB:M14031 SP:P23898 PID:145446 GB:U00096 PID:1742788; lipoprotein 1392540 nlpC 949594 nlpC Haemophilus influenzae Rd KW20 lipoprotein NP_439465.1 1392055 D 71421 CDS NP_439466.2 30995442 950581 1392718..1393023 1 NC_000907.1 hypothetical protein 1393023 950581 HI1315 Haemophilus influenzae Rd KW20 hypothetical protein NP_439466.2 1392718 D 71421 CDS NP_439467.2 30995443 950238 1393010..1393996 1 NC_000907.1 sulfatase-like protein 1393996 950238 HI1316 Haemophilus influenzae Rd KW20 sulfatase-like protein NP_439467.2 1393010 D 71421 CDS NP_439468.1 16273229 950209 1394078..1394893 1 NC_000907.1 similar to GB:U00096 SP:P39173 PID:1736408 PID:1742898 PID:1788080; hypothetical protein 1394893 950209 HI1317 Haemophilus influenzae Rd KW20 hypothetical protein NP_439468.1 1394078 D 71421 CDS NP_439469.1 16273648 950242 1395026..1395568 1 NC_000907.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1395568 infC 950242 infC Haemophilus influenzae Rd KW20 translation initiation factor IF-3 NP_439469.1 1395026 D 71421 CDS NP_439470.1 16273679 950241 1395779..1395976 1 NC_000907.1 50S ribosomal protein L35 1395976 rpmI 950241 rpmI Haemophilus influenzae Rd KW20 50S ribosomal protein L35 NP_439470.1 1395779 D 71421 CDS NP_439471.1 16273230 950247 1396043..1396396 1 NC_000907.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1396396 rplT 950247 rplT Haemophilus influenzae Rd KW20 50S ribosomal protein L20 NP_439471.1 1396043 D 71421 CDS NP_439472.1 16273231 950246 1396509..1400144 1 NC_000907.1 similar to SP:P08394 GB:X04581 GB:X04582 PID:42682 PID:763090; exodeoxyribonuclease V subunit beta 1400144 recB 950246 recB Haemophilus influenzae Rd KW20 exodeoxyribonuclease V subunit beta NP_439472.1 1396509 D 71421 CDS NP_439473.1 16273232 950249 1400144..1402066 1 NC_000907.1 similar to SP:P04993 GB:X04581 GB:X04582 PID:42683 PID:42691; exodeoxyribonuclease V subunit alpha 1402066 recD 950249 recD Haemophilus influenzae Rd KW20 exodeoxyribonuclease V subunit alpha NP_439473.1 1400144 D 71421 CDS NP_439474.1 16273233 950258 complement(1402135..1402581) 1 NC_000907.1 similar to SP:P45569 GB:U00096 PID:1787190; hypothetical protein 1402581 950258 HI1323 Haemophilus influenzae Rd KW20 hypothetical protein NP_439474.1 1402135 R 71421 CDS NP_439475.1 16273234 950250 1402678..1404483 1 NC_000907.1 similar to GB:D00863 SP:P36772 PID:402504; lon protease 1404483 950250 HI1324 Haemophilus influenzae Rd KW20 lon protease NP_439475.1 1402678 D 71421 CDS NP_439476.1 16273235 950257 1404652..1405185 1 NC_000907.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-ACP dehydratase 1405185 fabA 950257 fabA Haemophilus influenzae Rd KW20 3-hydroxydecanoyl-ACP dehydratase NP_439476.1 1404652 D 71421 CDS NP_439477.1 16273236 950251 1405419..1406147 1 NC_000907.1 hypothetical protein 1406147 950251 HI1326 Haemophilus influenzae Rd KW20 hypothetical protein NP_439477.1 1405419 D 71421 CDS NP_439478.1 16273237 950255 1406144..1406281 1 NC_000907.1 hypothetical protein 1406281 950255 HI1327 Haemophilus influenzae Rd KW20 hypothetical protein NP_439478.1 1406144 D 71421 CDS NP_439479.1 16273238 950244 1406417..1406686 1 NC_000907.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1406686 rpsO 950244 rpsO Haemophilus influenzae Rd KW20 30S ribosomal protein S15 NP_439479.1 1406417 D 71421 CDS NP_439482.1 16273241 950252 complement(1407458..1408897) 1 NC_000907.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase/endopeptidase 1408897 dacB 950252 dacB Haemophilus influenzae Rd KW20 D-alanyl-D-alanine carboxypeptidase/endopeptidase NP_439482.1 1407458 R 71421 CDS NP_439483.1 16273242 950254 1409061..1409537 1 NC_000907.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1409537 greA 950254 greA Haemophilus influenzae Rd KW20 transcription elongation factor GreA NP_439483.1 1409061 D 71421 CDS NP_439484.1 16273243 949671 complement(1409576..1409875) 1 NC_000907.1 contains RNA-binding domains; monomeric; similar to SP:P42550 PID:606118 GB:U00096 PID:1789570; hypothetical protein 1409875 yhbY 949671 yhbY Haemophilus influenzae Rd KW20 hypothetical protein NP_439484.1 1409576 R 71421 CDS NP_439485.1 16273244 950794 1410002..1410631 1 NC_000907.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase J 1410631 rrmJ 950794 rrmJ Haemophilus influenzae Rd KW20 23S rRNA methyltransferase J NP_439485.1 1410002 D 71421 CDS NP_439486.1 16273245 950795 1410722..1412629 1 NC_000907.1 similar to GB:M83138 SP:P28691 GB:U01376 PID:146028 PID:606116; cell division protein 1412629 ftsH 950795 ftsH Haemophilus influenzae Rd KW20 cell division protein NP_439486.1 1410722 D 71421 CDS NP_439487.1 16273246 950701 1412741..1413568 1 NC_000907.1 similar to GB:L06494 SP:P26282 GB:U01376 GB:X68776 GB:X68777; dihydropteroate synthase 1413568 folP-1 950701 folP-1 Haemophilus influenzae Rd KW20 dihydropteroate synthase NP_439487.1 1412741 D 71421 CDS NP_439488.1 16273247 950893 1413606..1414943 1 NC_000907.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 1414943 glmM 950893 glmM Haemophilus influenzae Rd KW20 phosphoglucosamine mutase NP_439488.1 1413606 D 71421 CDS NP_439489.1 16273248 950260 1415002..1415496 1 NC_000907.1 similar to GB:U00096 PID:1788681; hypothetical protein 1415496 950260 HI1338 Haemophilus influenzae Rd KW20 hypothetical protein NP_439489.1 1415002 D 71421 CDS NP_439490.1 16273249 950818 1415698..1416087 1 NC_000907.1 hypothetical protein 1416087 950818 HI1339 Haemophilus influenzae Rd KW20 hypothetical protein NP_439490.1 1415698 D 71421 CDS NP_439491.1 16273250 950814 complement(1416165..1417490) 1 NC_000907.1 similar to PID:882689 GB:U00096 SP:Q46920 PID:1789158; hypothetical protein 1417490 950814 HI1340 Haemophilus influenzae Rd KW20 hypothetical protein NP_439491.1 1416165 R 71421 CDS NP_439492.1 16273251 950616 complement(1417617..1418228) 1 NC_000907.1 hemoglobin-binding protein 1418228 950616 HI1341 Haemophilus influenzae Rd KW20 hemoglobin-binding protein NP_439492.1 1417617 R 71421 CDS NP_439493.1 16273252 949643 complement(1418131..1418847) 1 NC_000907.1 hypothetical protein 1418847 949643 HI1343 Haemophilus influenzae Rd KW20 hypothetical protein NP_439493.1 1418131 R 71421 CDS NP_439494.1 16273253 950264 1418744..1420123 1 NC_000907.1 similar to SP:P43672 GB:U00096 PID:1787182 PID:2251144; ABC transporter ATP-binding protein 1420123 950264 HI1342 Haemophilus influenzae Rd KW20 ABC transporter ATP-binding protein NP_439494.1 1418744 D 71421 CDS NP_439495.1 16273254 950266 complement(1420204..1421343) 1 NC_000907.1 similar to PID:1142681; spermidine/putrescine ABC transporter substrate-binding protein 1421343 potD 950266 potD Haemophilus influenzae Rd KW20 spermidine/putrescine ABC transporter substrate-binding protein NP_439495.1 1420204 R 71421 CDS NP_439496.1 16273255 950267 complement(1421416..1422159) 1 NC_000907.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein 1422159 potC 950267 potC Haemophilus influenzae Rd KW20 spermidine/putrescine ABC transporter membrane protein NP_439496.1 1421416 R 71421 CDS NP_439497.1 16273256 950272 complement(1422185..1423045) 1 NC_000907.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein 1423045 potB 950272 potB Haemophilus influenzae Rd KW20 spermidine/putrescine ABC transporter membrane protein NP_439497.1 1422185 R 71421 CDS NP_439498.2 30995444 950268 complement(1423029..1424177) 1 NC_000907.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase 1424177 potA 950268 potA Haemophilus influenzae Rd KW20 putrescine/spermidine ABC transporter ATPase NP_439498.2 1423029 R 71421 CDS NP_439499.1 16273258 950265 1424443..1425681 1 NC_000907.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1425681 pepT 950265 pepT Haemophilus influenzae Rd KW20 peptidase T NP_439499.1 1424443 D 71421 CDS NP_439500.1 16273259 950182 complement(1426245..1426727) 1 NC_000907.1 similar to PID:1652428; hypothetical protein 1426727 950182 HI1349 Haemophilus influenzae Rd KW20 hypothetical protein NP_439500.1 1426245 R 71421 CDS NP_439501.1 16273260 950271 1427001..1427879 1 NC_000907.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 1427879 cdd 950271 cdd Haemophilus influenzae Rd KW20 cytidine deaminase NP_439501.1 1427001 D 71421 CDS NP_439502.1 16273261 950443 complement(1427922..1428887) 1 NC_000907.1 similar to GB:U00096 PID:1788178; hypothetical protein 1428887 950443 HI1351 Haemophilus influenzae Rd KW20 hypothetical protein NP_439502.1 1427922 R 71421 CDS NP_439503.1 16273262 950133 complement(1428884..1430398) 1 NC_000907.1 proline permease; similar to GB:D32069 PID:509694 PID:913690; sodium/proline symporter 1430398 putP 950133 putP Haemophilus influenzae Rd KW20 sodium/proline symporter NP_439503.1 1428884 R 71421 CDS NP_439504.1 16273263 950270 1430514..1431989 1 NC_000907.1 involved in the processing of the 5'end of 16S rRNA; ribonuclease G 1431989 cafA 950270 cafA Haemophilus influenzae Rd KW20 ribonuclease G NP_439504.1 1430514 D 71421 CDS NP_439505.1 16273264 950274 1432409..1434082 1 NC_000907.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 1434082 glnS 950274 glnS Haemophilus influenzae Rd KW20 glutaminyl-tRNA synthetase NP_439505.1 1432409 D 71421 CDS NP_439506.1 16273265 950283 1434148..1434612 1 NC_000907.1 similar to GB:U00096 PID:1787429; hypothetical protein 1434612 950283 HI1355 Haemophilus influenzae Rd KW20 hypothetical protein NP_439506.1 1434148 D 71421 CDS NP_439507.1 16273266 950287 1434674..1436773 1 NC_000907.1 similar to GB:M32793 SP:P15977 PID:146715 PID:606351 GB:U00096; 4-alpha-glucanotransferase 1436773 malQ 950287 malQ Haemophilus influenzae Rd KW20 4-alpha-glucanotransferase NP_439507.1 1434674 D 71421 CDS NP_439508.1 16273267 950275 1436783..1438975 1 NC_000907.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 1438975 glgB 950275 glgB Haemophilus influenzae Rd KW20 glycogen branching protein NP_439508.1 1436783 D 71421 CDS NP_439509.1 16273268 949470 1439071..1441050 1 NC_000907.1 similar to GB:J01616 SP:P15067 PID:146135 PID:606366 GB:U00096; glycogen operon protein 1441050 glgX 949470 glgX Haemophilus influenzae Rd KW20 glycogen operon protein NP_439509.1 1439071 D 71421 CDS NP_439510.1 16273269 950593 1441040..1442374 1 NC_000907.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1442374 glgC 950593 glgC Haemophilus influenzae Rd KW20 glucose-1-phosphate adenylyltransferase NP_439510.1 1441040 D 71421 CDS NP_439511.1 16273270 950277 1442482..1443912 1 NC_000907.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 1443912 glgA 950277 glgA Haemophilus influenzae Rd KW20 glycogen synthase NP_439511.1 1442482 D 71421 CDS NP_439512.1 16273271 950286 1444158..1446623 1 NC_000907.1 similar to GB:J03966 SP:P13031 GB:M22368 GB:X16931 PID:146146; hypothetical protein 1446623 950286 HI1361 Haemophilus influenzae Rd KW20 hypothetical protein NP_439512.1 1444158 D 71421 CDS NP_439513.1 16273272 950278 1446885..1448423 1 NC_000907.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 1448423 pntA 950278 pntA Haemophilus influenzae Rd KW20 NAD(P) transhydrogenase subunit alpha NP_439513.1 1446885 D 71421 CDS NP_439514.1 16273273 950280 1448434..1449858 1 NC_000907.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 1449858 pntB 950280 pntB Haemophilus influenzae Rd KW20 pyridine nucleotide transhydrogenase NP_439514.1 1448434 D 71421 CDS NP_439515.1 16273274 950273 complement(1449976..1450842) 1 NC_000907.1 similar to SP:P37641 PID:466658 GB:U00096 PID:1789938; transcriptional regulator 1450842 950273 HI1364 Haemophilus influenzae Rd KW20 transcriptional regulator NP_439515.1 1449976 R 71421 CDS NP_439516.1 16273275 950025 1450938..1453544 1 NC_000907.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1453544 topA 950025 topA Haemophilus influenzae Rd KW20 DNA topoisomerase I NP_439516.1 1450938 D 71421 CDS NP_439517.1 16273276 950279 complement(1453620..1454204) 1 NC_000907.1 similar to GB:U00096 PID:1742298 PID:1742303 PID:1787680; acyl carrier protein phosphodiesterase 1454204 acpD 950279 acpD Haemophilus influenzae Rd KW20 acyl carrier protein phosphodiesterase NP_439517.1 1453620 R 71421 CDS NP_439518.1 16273277 950281 1454489..1456420 1 NC_000907.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 1456420 thrS 950281 thrS Haemophilus influenzae Rd KW20 threonyl-tRNA synthetase NP_439518.1 1454489 D 71421 CDS NP_439519.1 16273278 950673 complement(1456539..1459319) 1 NC_000907.1 similar to SP:P31828 GB:X71917 PID:535004 GB:U00096 PID:1742451; zinc protease 1459319 950673 HI1368 Haemophilus influenzae Rd KW20 zinc protease NP_439519.1 1456539 R 71421 CDS NP_439520.1 16273279 950892 complement(1459423..1461942) 1 NC_000907.1 similar to SP:P31827 GB:X71917 PID:311346 GB:U00096 PID:1787771; hypothetical protein 1461942 950892 HI1369 Haemophilus influenzae Rd KW20 hypothetical protein NP_439520.1 1459423 R 71421 CDS NP_439521.1 16273280 950284 complement(1461986..1462195) 1 NC_000907.1 similar to GB:M17157 SP:P04952 SP:P08854 GB:M17158 GB:X04982; molybdenum-pterin binding protein 1462195 mopI 950284 mopI Haemophilus influenzae Rd KW20 molybdenum-pterin binding protein NP_439521.1 1461986 R 71421 CDS NP_439522.1 16273281 950285 complement(1462303..1462632) 1 NC_000907.1 similar to GB:L05610 SP:P45573 PID:145087; dissimilatory sulfite reductase, desulfoviridin subunit gamma 1462632 950285 HI1371 Haemophilus influenzae Rd KW20 dissimilatory sulfite reductase, desulfoviridin subunit gamma NP_439522.1 1462303 R 71421 CDS NP_439523.1 16273282 950672 complement(1462634..1463575) 1 NC_000907.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1463575 950672 HI1371.1 Haemophilus influenzae Rd KW20 C32 tRNA thiolase NP_439523.1 1462634 R 71421 CDS NP_439524.2 30995445 950891 1463725..1465059 1 NC_000907.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 1465059 kicB 950891 kicB Haemophilus influenzae Rd KW20 condesin subunit F NP_439524.2 1463725 D 71421 CDS NP_439525.1 16273284 950288 1465106..1465837 1 NC_000907.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 1465837 kicA 950288 kicA Haemophilus influenzae Rd KW20 condesin subunit E NP_439525.1 1465106 D 71421 CDS NP_439526.1 16273285 950289 1465837..1470369 1 NC_000907.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 1470369 mukB 950289 mukB Haemophilus influenzae Rd KW20 cell division protein MukB NP_439526.1 1465837 D 71421 CDS NP_439527.1 16273286 950817 1470440..1471348 1 NC_000907.1 hypothetical protein 1471348 950817 HI1375 Haemophilus influenzae Rd KW20 hypothetical protein NP_439527.1 1470440 D 71421 CDS NP_439528.1 16273287 950804 1471351..1472226 1 NC_000907.1 hypothetical protein 1472226 950804 HI1376 Haemophilus influenzae Rd KW20 hypothetical protein NP_439528.1 1471351 D 71421 CDS NP_439529.1 16273288 950828 1472239..1473660 1 NC_000907.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 1473660 sbcB 950828 sbcB Haemophilus influenzae Rd KW20 exonuclease I NP_439529.1 1472239 D 71421 CDS NP_439530.1 16273289 950291 complement(1474351..1475628) 1 NC_000907.1 similar to SP:P08400 GB:X04704 PID:581188 GB:U00096 PID:1657596; phosphate regulon sensor protein PhoR 1475628 phoR 950291 phoR Haemophilus influenzae Rd KW20 phosphate regulon sensor protein PhoR NP_439530.1 1474351 R 71421 CDS NP_439531.1 16273290 950671 complement(1475625..1476320) 1 NC_000907.1 similar to SP:P08402 GB:X04026 PID:42388 GB:U00096 PID:1657595; phosphate regulon transcriptional regulatory protein PhoB 1476320 phoB 950671 phoB Haemophilus influenzae Rd KW20 phosphate regulon transcriptional regulatory protein PhoB NP_439531.1 1475625 R 71421 CDS NP_439533.1 16273291 950294 complement(1477193..1478041) 1 NC_000907.1 similar to GB:L10328 SP:P07654 GB:K01992 GB:X02723 PID:147258; phosphate ABC transporter permease 1478041 pstA 950294 pstA Haemophilus influenzae Rd KW20 phosphate ABC transporter permease NP_439533.1 1477193 R 71421 CDS NP_439534.1 16273292 950295 complement(1478043..1478990) 1 NC_000907.1 similar to GB:L10328 SP:P07653 GB:K01992 GB:X02723 PID:147257; phosphate ABC transporter permease 1478990 pstC 950295 pstC Haemophilus influenzae Rd KW20 phosphate ABC transporter permease NP_439534.1 1478043 R 71421 CDS NP_439535.1 16273649 950702 complement(join(1479081..1480076,1480076..1480084)) 1 NC_000907.1 phosphate ABC transporter substrate-binding protein 1480084 pstS 950702 pstS Haemophilus influenzae Rd KW20 phosphate ABC transporter substrate-binding protein NP_439535.1 1479081 R 71421 CDS NP_439536.1 16273293 950297 1480541..1481089 1 NC_000907.1 similar to SP:P23887 GB:X53513 PID:42898 GB:U00096 PID:1736567; ferritin like protein 1 1481089 rsgA 950297 rsgA Haemophilus influenzae Rd KW20 ferritin like protein 1 NP_439536.1 1480541 D 71421 CDS NP_439537.1 16273294 950298 1481105..1481602 1 NC_000907.1 similar to SP:P23887 GB:X53513 PID:42898 GB:U00096 PID:1736567; ferritin 1481602 rsgA 950298 rsgA Haemophilus influenzae Rd KW20 ferritin NP_439537.1 1481105 D 71421 CDS NP_439538.1 16273295 950299 1481976..1482422 1 NC_000907.1 hypothetical protein 1482422 950299 HI1386 Haemophilus influenzae Rd KW20 hypothetical protein NP_439538.1 1481976 D 71421 CDS NP_439539.1 16273296 950300 1482528..1484084 1 NC_000907.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1484084 trpE 950300 trpE Haemophilus influenzae Rd KW20 anthranilate synthase component I NP_439539.1 1482528 D 71421 CDS NP_439540.1 16273297 950293 1484097..1484678 1 NC_000907.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 1484678 trpG 950293 trpG Haemophilus influenzae Rd KW20 anthranilate synthase component II NP_439540.1 1484097 D 71421 CDS NP_439541.1 16273298 950703 1484727..1485113 1 NC_000907.1 hypothetical protein 1485113 950703 HI1388.1 Haemophilus influenzae Rd KW20 hypothetical protein NP_439541.1 1484727 D 71421 CDS NP_439542.1 16273299 950894 1485166..1486167 1 NC_000907.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1486167 trpD 950894 trpD Haemophilus influenzae Rd KW20 anthranilate phosphoribosyltransferase NP_439542.1 1485166 D 71421 CDS NP_439543.1 16273300 950301 1486204..1487637 1 NC_000907.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1487637 trpC 950301 trpC Haemophilus influenzae Rd KW20 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase NP_439543.1 1486204 D 71421 CDS YP_008530237.1 542123262 950155 1487699..1487971 1 NC_000907.1 hydrogenase 2 accessory protein 1487971 hybG 950155 hybG Haemophilus influenzae Rd KW20 hydrogenase 2 accessory protein YP_008530237.1 1487699 D 71421 CDS NP_439545.1 16273301 950584 complement(1488005..1490869) 1 NC_000907.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 1490869 valS 950584 valS Haemophilus influenzae Rd KW20 valyl-tRNA synthetase NP_439545.1 1488005 R 71421 CDS NP_439546.1 16273302 950302 complement(1490870..1491799) 1 NC_000907.1 similar to GB:L15391 PID:1574226; modification methylase 1491799 hindIIIM 950302 hindIIIM Haemophilus influenzae Rd KW20 modification methylase NP_439546.1 1490870 R 71421 CDS NP_439547.1 16273303 950303 complement(1491780..1492682) 1 NC_000907.1 similar to GB:L15391 PID:1574230; type II restriction endonuclease 1492682 hindIIIR 950303 hindIIIR Haemophilus influenzae Rd KW20 type II restriction endonuclease NP_439547.1 1491780 R 71421 CDS NP_439548.1 16273304 950304 complement(1492630..1493001) 1 NC_000907.1 similar to PID:887850 GB:U00096 SP:Q46828 PID:1789267; hypothetical protein 1493001 950304 HI1394 Haemophilus influenzae Rd KW20 hypothetical protein NP_439548.1 1492630 R 71421 CDS NP_439550.1 16273306 950308 complement(1493866..1494300) 1 NC_000907.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 1494300 holC 950308 holC Haemophilus influenzae Rd KW20 DNA polymerase III subunit chi NP_439550.1 1493866 R 71421 CDS NP_439551.1 16273307 950314 1494535..1495929 1 NC_000907.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1495929 fumC 950314 fumC Haemophilus influenzae Rd KW20 fumarate hydratase NP_439551.1 1494535 D 71421 CDS NP_439552.1 16273308 950317 1496057..1496665 1 NC_000907.1 hypothetical protein 1496665 950317 HI1399 Haemophilus influenzae Rd KW20 hypothetical protein NP_439552.1 1496057 D 71421 CDS NP_439553.1 16273309 950717 complement(1496764..1497588) 1 NC_000907.1 similar to GB:U00096 PID:1787520; hypothetical protein 1497588 950717 HI1400 Haemophilus influenzae Rd KW20 hypothetical protein NP_439553.1 1496764 R 71421 CDS NP_439554.1 16273310 950325 complement(1497588..1498607) 1 NC_000907.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1498607 pyrD 950325 pyrD Haemophilus influenzae Rd KW20 dihydroorotate dehydrogenase 2 NP_439554.1 1497588 R 71421 CDS NP_439556.1 16273312 950856 complement(1499076..1499624) 1 NC_000907.1 tail fiber protein/phosphomannomutase 1499624 yhxB 950856 yhxB Haemophilus influenzae Rd KW20 tail fiber protein/phosphomannomutase NP_439556.1 1499076 R 71421 CDS NP_439557.1 16273313 950333 complement(1500122..1501222) 1 NC_000907.1 hypothetical protein 1501222 950333 HI1405 Haemophilus influenzae Rd KW20 hypothetical protein NP_439557.1 1500122 R 71421 CDS NP_439558.1 16273314 950830 complement(1501283..1501639) 1 NC_000907.1 hypothetical protein 1501639 950830 HI1406 Haemophilus influenzae Rd KW20 hypothetical protein NP_439558.1 1501283 R 71421 CDS NP_439559.1 16273315 950320 complement(1502127..1503470) 1 NC_000907.1 similar to GB:L10330 PID:437700; plasmid RP4 TraN-like protein 1503470 950320 HI1407 Haemophilus influenzae Rd KW20 plasmid RP4 TraN-like protein NP_439559.1 1502127 R 71421 CDS NP_439560.1 16273316 950321 complement(1503394..1504704) 1 NC_000907.1 hypothetical protein 1504704 950321 HI1409 Haemophilus influenzae Rd KW20 hypothetical protein NP_439560.1 1503394 R 71421 CDS NP_439561.1 16273317 950727 complement(1504706..1505890) 1 NC_000907.1 terminase large subunit-like protein 1505890 950727 HI1410 Haemophilus influenzae Rd KW20 terminase large subunit-like protein NP_439561.1 1504706 R 71421 CDS NP_439562.1 16273318 950482 complement(1506035..1506550) 1 NC_000907.1 similar to SP:Q38627 PID:522116; terminase small subunit 1506550 950482 HI1411 Haemophilus influenzae Rd KW20 terminase small subunit NP_439562.1 1506035 R 71421 CDS NP_439563.1 16273319 950722 complement(1506560..1507081) 1 NC_000907.1 similar to SP:P21417 PID:1196685; hypothetical protein 1507081 950722 HI1412 Haemophilus influenzae Rd KW20 hypothetical protein NP_439563.1 1506560 R 71421 CDS NP_439564.1 16273320 949414 complement(1507209..1507490) 1 NC_000907.1 hypothetical protein 1507490 949414 HI1413 Haemophilus influenzae Rd KW20 hypothetical protein NP_439564.1 1507209 R 71421 CDS NP_439565.1 16273321 950322 complement(1507402..1507677) 1 NC_000907.1 hypothetical protein 1507677 950322 HI1414 Haemophilus influenzae Rd KW20 hypothetical protein NP_439565.1 1507402 R 71421 CDS NP_439566.1 16273322 950713 complement(1507670..1508272) 1 NC_000907.1 hypothetical protein 1508272 950713 HI1415 Haemophilus influenzae Rd KW20 hypothetical protein NP_439566.1 1507670 R 71421 CDS NP_439567.1 16273323 950758 complement(1508241..1508597) 1 NC_000907.1 hypothetical protein 1508597 950758 HI1416 Haemophilus influenzae Rd KW20 hypothetical protein NP_439567.1 1508241 R 71421 CDS NP_439568.2 30995448 950323 complement(1509035..1509601) 1 NC_000907.1 hypothetical protein 1509601 950323 HI1418 Haemophilus influenzae Rd KW20 hypothetical protein NP_439568.2 1509035 R 71421 CDS NP_439569.1 16273325 949900 1509962..1510261 1 NC_000907.1 hypothetical protein 1510261 949900 HI1419 Haemophilus influenzae Rd KW20 hypothetical protein NP_439569.1 1509962 D 71421 CDS NP_439570.1 16273326 950760 1510258..1510551 1 NC_000907.1 hypothetical protein 1510551 950760 HI1420 Haemophilus influenzae Rd KW20 hypothetical protein NP_439570.1 1510258 D 71421 CDS NP_439571.1 16273327 949966 1511013..1511588 1 NC_000907.1 hypothetical protein 1511588 949966 HI1422 Haemophilus influenzae Rd KW20 hypothetical protein NP_439571.1 1511013 D 71421 CDS NP_439572.1 16273328 950324 1511874..1512158 1 NC_000907.1 hypothetical protein 1512158 950324 HI1423 Haemophilus influenzae Rd KW20 hypothetical protein NP_439572.1 1511874 D 71421 CDS NP_439573.1 16273329 950326 complement(1512159..1513073) 1 NC_000907.1 similar to SP:P10487 GB:D90039 SP:P16470 GB:AB027308 GB:AB027308; integrase/recombinase 1513073 950326 HI1424 Haemophilus influenzae Rd KW20 integrase/recombinase NP_439573.1 1512159 R 71421 CDS NP_439574.1 16273330 950327 1513585..1514358 1 NC_000907.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 1514358 fnr 950327 fnr Haemophilus influenzae Rd KW20 fumarate/nitrate reduction transcriptional regulator NP_439574.1 1513585 D 71421 CDS NP_439575.2 161350020 950328 1514479..1515408 1 NC_000907.1 with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 1515408 950328 HI1426 Haemophilus influenzae Rd KW20 universal stress protein UspE NP_439575.2 1514479 D 71421 CDS NP_439576.1 16273332 950330 1515608..1516444 1 NC_000907.1 hypothetical protein 1516444 950330 HI1427 Haemophilus influenzae Rd KW20 hypothetical protein NP_439576.1 1515608 D 71421 CDS NP_439577.1 16273333 950331 complement(1516529..1517167) 1 NC_000907.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 1517167 purN 950331 purN Haemophilus influenzae Rd KW20 phosphoribosylglycinamide formyltransferase NP_439577.1 1516529 R 71421 CDS NP_439578.1 16273334 950335 complement(1517222..1518256) 1 NC_000907.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 1518256 purM 950335 purM Haemophilus influenzae Rd KW20 phosphoribosylaminoimidazole synthetase NP_439578.1 1517222 R 71421 CDS NP_439579.1 16273335 950332 1518436..1519194 1 NC_000907.1 similar to GB:U00096 PID:1787820; short chain dehydrogenase/reductase 1519194 950332 HI1430 Haemophilus influenzae Rd KW20 short chain dehydrogenase/reductase NP_439579.1 1518436 D 71421 CDS NP_439580.1 16273336 950336 1519211..1520404 1 NC_000907.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1520404 trpB 950336 trpB Haemophilus influenzae Rd KW20 tryptophan synthase subunit beta NP_439580.1 1519211 D 71421 CDS NP_439581.1 16273337 950337 1520404..1521210 1 NC_000907.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1521210 trpA 950337 trpA Haemophilus influenzae Rd KW20 tryptophan synthase subunit alpha NP_439581.1 1520404 D 71421 CDS NP_439582.1 16273338 950338 complement(1521348..1522301) 1 NC_000907.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 1522301 usg1 950338 usg1 Haemophilus influenzae Rd KW20 aspartate-semialdehyde dehydrogenase NP_439582.1 1521348 R 71421 CDS NP_439583.1 16273339 949657 1522360..1522836 1 NC_000907.1 contains a C-type lectin fold; similar to prolyl-tRNA synthetases; similar to GB:L23802 SP:P36922 PID:388109; hypothetical protein 1522836 ybaK 949657 ybaK Haemophilus influenzae Rd KW20 hypothetical protein NP_439583.1 1522360 D 71421 CDS NP_439584.1 16273340 949903 complement(1522993..1523211) 1 NC_000907.1 similar to SP:P24245 GB:U00096 PID:1651400 PID:1787107; cold shock-like protein 1523211 cspD 949903 cspD Haemophilus influenzae Rd KW20 cold shock-like protein NP_439584.1 1522993 R 71421 CDS NP_439585.2 30995449 949916 complement(1523361..1523519) 1 NC_000907.1 similar to GB:U00096 PID:1788113; hypothetical protein 1523519 949916 HI1434.2 Haemophilus influenzae Rd KW20 hypothetical protein NP_439585.2 1523361 R 71421 CDS NP_439587.1 16273343 950784 complement(1524226..1524546) 1 NC_000907.1 similar to PID:882688 GB:U00096 PID:882687; hypothetical protein 1524546 950784 HI1436 Haemophilus influenzae Rd KW20 hypothetical protein NP_439587.1 1524226 R 71421 CDS NP_439589.1 16273344 950341 1526179..1526433 1 NC_000907.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 1526433 xseB 950341 xseB Haemophilus influenzae Rd KW20 exodeoxyribonuclease VII small subunit NP_439589.1 1526179 D 71421 CDS NP_439590.1 16273345 950833 1526433..1527320 1 NC_000907.1 similar to GB:D00694 SP:P22939 PID:216584 GB:U00096 PID:1773105; geranyltranstransferase 1527320 ispA 950833 ispA Haemophilus influenzae Rd KW20 geranyltranstransferase NP_439590.1 1526433 D 71421 CDS NP_439591.1 16273346 950315 1527362..1529239 1 NC_000907.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 1529239 dxs 950315 dxs Haemophilus influenzae Rd KW20 1-deoxy-D-xylulose-5-phosphate synthase NP_439591.1 1527362 D 71421 CDS NP_439592.1 16273347 950343 complement(1529275..1529727) 1 NC_000907.1 similar to GB:M69028 SP:P25663 GB:X05088 PID:147872 PID:42999; ClpXP protease specificity-enhancing factor 1529727 sspB 950343 sspB Haemophilus influenzae Rd KW20 ClpXP protease specificity-enhancing factor NP_439592.1 1529275 R 71421 CDS NP_439593.1 16273348 950832 complement(1529727..1530365) 1 NC_000907.1 similar to SP:P31784 PID:241868; stringent starvation protein A 1530365 sspA 950832 sspA Haemophilus influenzae Rd KW20 stringent starvation protein A NP_439593.1 1529727 R 71421 CDS NP_439594.1 16273349 950342 complement(1530546..1530938) 1 NC_000907.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 1530938 rpsI 950342 rpsI Haemophilus influenzae Rd KW20 30S ribosomal protein S9 NP_439594.1 1530546 R 71421 CDS NP_439595.1 16273350 950831 complement(1530955..1531383) 1 NC_000907.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 1531383 rplM 950831 rplM Haemophilus influenzae Rd KW20 50S ribosomal protein L13 NP_439595.1 1530955 R 71421 CDS NP_439596.1 16273351 950344 1531847..1532725 1 NC_000907.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 1532725 metF 950344 metF Haemophilus influenzae Rd KW20 5,10-methylenetetrahydrofolate reductase NP_439596.1 1531847 D 71421 CDS NP_439597.1 16273352 950720 complement(1532814..1533542) 1 NC_000907.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 1533542 bioD 950720 bioD Haemophilus influenzae Rd KW20 dithiobiotin synthetase NP_439597.1 1532814 R 71421 CDS NP_439598.1 16273353 950564 complement(1533645..1533968) 1 NC_000907.1 similar to GB:U00096 PID:1787427; hypothetical protein 1533968 950564 HI1446 Haemophilus influenzae Rd KW20 hypothetical protein NP_439598.1 1533645 R 71421 CDS NP_439599.1 16273354 950345 complement(1533972..1534628) 1 NC_000907.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 1534628 folE 950345 folE Haemophilus influenzae Rd KW20 GTP cyclohydrolase I NP_439599.1 1533972 R 71421 CDS NP_439600.1 16273355 950719 1534766..1535980 1 NC_000907.1 similar to GB:M21151 SP:P12281 PID:145539 GB:U00096 PID:1651376; molybdopterin biosynthesis protein 1535980 moeA 950719 moeA Haemophilus influenzae Rd KW20 molybdopterin biosynthesis protein NP_439600.1 1534766 D 71421 CDS NP_439601.1 16273356 950565 1535984..1536715 1 NC_000907.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 1536715 moeB 950565 moeB Haemophilus influenzae Rd KW20 molybdopterin biosynthesis protein MoeB NP_439601.1 1535984 D 71421 CDS NP_439602.1 16273357 950346 1536782..1537105 1 NC_000907.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 1537105 950346 HI1450 Haemophilus influenzae Rd KW20 dsDNA-mimic protein NP_439602.1 1536782 D 71421 CDS NP_439603.1 16273358 950785 complement(1537173..1537760) 1 NC_000907.1 hypothetical protein 1537760 950785 HI1452 Haemophilus influenzae Rd KW20 hypothetical protein NP_439603.1 1537173 R 71421 CDS NP_439604.1 16273359 950347 complement(1537998..1538468) 1 NC_000907.1 similar to GB:AL009126; phosphoribosylformylglycinamidine synthase 1538468 purL 950347 purL Haemophilus influenzae Rd KW20 phosphoribosylformylglycinamidine synthase NP_439604.1 1537998 R 71421 CDS NP_439605.1 16273360 950340 complement(1538510..1539151) 1 NC_000907.1 similar to SP:P45706 PID:870925 PID:1405449 GB:AL009126; hypothetical protein 1539151 950340 HI1454 Haemophilus influenzae Rd KW20 hypothetical protein NP_439605.1 1538510 R 71421 CDS NP_439606.1 16273361 950358 complement(1539163..1540224) 1 NC_000907.1 this fusion consists of methionine sulfoxide A reductase at the N-terminus and B at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion; bifunctional methionine sulfoxide reductase subunits A/B 1540224 msrA 950358 msrA Haemophilus influenzae Rd KW20 bifunctional methionine sulfoxide reductase subunits A/B NP_439606.1 1539163 R 71421 CDS NP_439607.2 30995450 950348 complement(1540419..1540868) 1 NC_000907.1 hypothetical protein 1540868 950348 HI1456 Haemophilus influenzae Rd KW20 hypothetical protein NP_439607.2 1540419 R 71421 CDS NP_439608.1 16273363 950146 complement(1540879..1541415) 1 NC_000907.1 similar to PID:2367659; opacity protein 1541415 950146 HI1457 Haemophilus influenzae Rd KW20 opacity protein NP_439608.1 1540879 R 71421 CDS NP_439610.2 30995451 950350 complement(1542231..1542776) 1 NC_000907.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor 1542776 950350 HI1459 Haemophilus influenzae Rd KW20 RNA polymerase sigma factor NP_439610.2 1542231 R 71421 CDS NP_439611.1 16273365 950787 1544081..1545445 1 NC_000907.1 similar to GB:U00096 SP:P77211 PID:1778487 PID:1786785; hypothetical protein 1545445 950787 HI1462 Haemophilus influenzae Rd KW20 hypothetical protein NP_439611.1 1544081 D 71421 CDS NP_439612.2 30995452 950572 complement(1545523..1545912) 1 NC_000907.1 hypothetical protein 1545912 950572 HI1462.1 Haemophilus influenzae Rd KW20 hypothetical protein NP_439612.2 1545523 R 71421 CDS NP_439613.1 16273367 950352 complement(1546114..1546608) 1 NC_000907.1 similar to GB:U00096 PID:1788681; hypothetical protein 1546608 950352 HI1462.2 Haemophilus influenzae Rd KW20 hypothetical protein NP_439613.1 1546114 R 71421 CDS NP_439614.1 16273368 950567 complement(1546667..1548004) 1 NC_000907.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 1548004 glmM 950567 glmM Haemophilus influenzae Rd KW20 phosphoglucosamine mutase NP_439614.1 1546667 R 71421 CDS NP_439615.1 16273369 950351 complement(1548042..1548869) 1 NC_000907.1 similar to GB:L06494 SP:P26282 GB:U01376 GB:X68776 GB:X68777; dihydropteroate synthase 1548869 folP-2 950351 folP-2 Haemophilus influenzae Rd KW20 dihydropteroate synthase NP_439615.1 1548042 R 71421 CDS NP_439616.1 16273370 950570 complement(1548981..1550126) 1 NC_000907.1 similar to GB:M83138 SP:P28691 GB:U01376 PID:146028 PID:606116; cell division FtsH-like protein 1550126 950570 HI1465 Haemophilus influenzae Rd KW20 cell division FtsH-like protein NP_439616.1 1548981 R 71421 CDS NP_439618.1 16273371 950646 1552525..1554294 1 NC_000907.1 similar to SP:Q50614 PID:1483552; ABC transporter ATP-binding protein 1554294 950646 HI1467 Haemophilus influenzae Rd KW20 ABC transporter ATP-binding protein NP_439618.1 1552525 D 71421 CDS NP_439619.1 16273372 950650 complement(1554432..1554701) 1 NC_000907.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1554701 rpsO 950650 rpsO Haemophilus influenzae Rd KW20 30S ribosomal protein S15 NP_439619.1 1554432 R 71421 CDS NP_439621.1 16273374 950600 complement(1555042..1555803) 1 NC_000907.1 similar to GB:AE000511 SP:O05732 PID:2072456 PID:2314024; iron chelatin ABC transporter ATP-binding protein 1555803 950600 HI1470 Haemophilus influenzae Rd KW20 iron chelatin ABC transporter ATP-binding protein NP_439621.1 1555042 R 71421 CDS NP_439622.1 16273375 950354 complement(1555796..1556809) 1 NC_000907.1 similar to GB:AE000511 SP:O05731 PID:2072455 PID:2314025; iron chelatin ABC transporter permease 1556809 950354 HI1471 Haemophilus influenzae Rd KW20 iron chelatin ABC transporter permease NP_439622.1 1555796 R 71421 CDS NP_439623.1 16273376 950575 complement(1556796..1557851) 1 NC_000907.1 similar to GB:AE000511 PID:2314746; iron chelatin ABC transporter substrate-binding protein 1557851 950575 HI1472 Haemophilus influenzae Rd KW20 iron chelatin ABC transporter substrate-binding protein NP_439623.1 1556796 R 71421 CDS NP_439624.1 16273377 950721 complement(1557919..1558764) 1 NC_000907.1 involved in molybdenum transport; molybdenum transport protein ModD 1558764 modD 950721 modD Haemophilus influenzae Rd KW20 molybdenum transport protein ModD NP_439624.1 1557919 R 71421 CDS NP_439625.1 16273378 950574 complement(1558774..1559373) 1 NC_000907.1 similar to GB:AE000511 PID:2313950; ABC transporter ATP-binding protein 1559373 950574 HI1474 Haemophilus influenzae Rd KW20 ABC transporter ATP-binding protein NP_439625.1 1558774 R 71421 CDS NP_439626.1 16273379 950353 complement(1559375..1559734) 1 NC_000907.1 hypothetical protein 1559734 950353 HI1475 Haemophilus influenzae Rd KW20 hypothetical protein NP_439626.1 1559375 R 71421 CDS NP_439627.1 16273380 950582 complement(1559962..1560681) 1 NC_000907.1 similar to SP:Q37906 PID:403436; transcriptional regulatory protein 1560681 950582 HI1476 Haemophilus influenzae Rd KW20 transcriptional regulatory protein NP_439627.1 1559962 R 71421 CDS NP_439628.1 16273381 950789 1560909..1561178 1 NC_000907.1 similar to SP:P06903; DNA-binding protein 1561178 ner 950789 ner Haemophilus influenzae Rd KW20 DNA-binding protein NP_439628.1 1560909 D 71421 CDS NP_439629.1 16273382 950583 1561212..1563275 1 NC_000907.1 similar to SP:P07636 PID:15450 PID:15810 PID:215511 PID:215547; transposase 1563275 muA 950583 muA Haemophilus influenzae Rd KW20 transposase NP_439629.1 1561212 D 71421 CDS NP_439630.1 16273383 950355 1563332..1563604 1 NC_000907.1 hypothetical protein 1563604 950355 HI1479 Haemophilus influenzae Rd KW20 hypothetical protein NP_439630.1 1563332 D 71421 CDS NP_439631.1 16273384 950577 complement(1563537..1564007) 1 NC_000907.1 hypothetical protein 1564007 950577 HI1480 Haemophilus influenzae Rd KW20 hypothetical protein NP_439631.1 1563537 R 71421 CDS NP_439632.1 16273385 950585 1564041..1564904 1 NC_000907.1 similar to SP:P03763 PID:15448 PID:215512 PID:215550; DNA transposition protein 1564904 muB 950585 muB Haemophilus influenzae Rd KW20 DNA transposition protein NP_439632.1 1564041 D 71421 CDS NP_439633.1 16273386 950568 1564965..1565282 1 NC_000907.1 hypothetical protein 1565282 950568 HI1482 Haemophilus influenzae Rd KW20 hypothetical protein NP_439633.1 1564965 D 71421 CDS NP_439634.1 16273387 950566 1565297..1565806 1 NC_000907.1 similar to SP:P06023 PID:15461 PID:215562; host-nuclease inhibitor protein 1565806 gam 950566 gam Haemophilus influenzae Rd KW20 host-nuclease inhibitor protein NP_439634.1 1565297 D 71421 CDS NP_439635.1 16273388 950356 1566436..1566657 1 NC_000907.1 hypothetical protein 1566657 950356 HI1485 Haemophilus influenzae Rd KW20 hypothetical protein NP_439635.1 1566436 D 71421 CDS NP_439636.1 16273389 950578 1566657..1566830 1 NC_000907.1 hypothetical protein 1566830 950578 HI1486 Haemophilus influenzae Rd KW20 hypothetical protein NP_439636.1 1566657 D 71421 CDS NP_439637.1 16273390 950580 1566833..1567393 1 NC_000907.1 hypothetical protein 1567393 950580 HI1487 Haemophilus influenzae Rd KW20 hypothetical protein NP_439637.1 1566833 D 71421 CDS NP_439638.1 16273391 950788 1567567..1568124 1 NC_000907.1 similar to PID:215574; hypothetical protein 1568124 950788 HI1488 Haemophilus influenzae Rd KW20 hypothetical protein NP_439638.1 1567567 D 71421 CDS NP_439639.1 16273392 950579 1568121..1568675 1 NC_000907.1 hypothetical protein 1568675 950579 HI1489 Haemophilus influenzae Rd KW20 hypothetical protein NP_439639.1 1568121 D 71421 CDS NP_439641.1 16273393 950359 1569309..1569815 1 NC_000907.1 hypothetical protein 1569815 950359 HI1492 Haemophilus influenzae Rd KW20 hypothetical protein NP_439641.1 1569309 D 71421 CDS NP_439642.1 16273394 950360 1569897..1570181 1 NC_000907.1 hypothetical protein 1570181 950360 HI1493 Haemophilus influenzae Rd KW20 hypothetical protein NP_439642.1 1569897 D 71421 CDS NP_439644.1 16273396 950744 1570448..1570708 1 NC_000907.1 hypothetical protein 1570708 950744 HI1495 Haemophilus influenzae Rd KW20 hypothetical protein NP_439644.1 1570448 D 71421 CDS NP_439645.1 16273397 950362 1570705..1570959 1 NC_000907.1 hypothetical protein 1570959 950362 HI1496 Haemophilus influenzae Rd KW20 hypothetical protein NP_439645.1 1570705 D 71421 CDS NP_439646.1 16273398 950363 1571077..1571304 1 NC_000907.1 similar to SP:Q06424 PID:288658; hypothetical protein 1571304 950363 HI1497 Haemophilus influenzae Rd KW20 hypothetical protein NP_439646.1 1571077 D 71421 CDS NP_439647.1 16273399 950364 1571211..1571630 1 NC_000907.1 hypothetical protein 1571630 950364 HI1498 Haemophilus influenzae Rd KW20 hypothetical protein NP_439647.1 1571211 D 71421 CDS NP_439648.1 16273400 950365 1571635..1571943 1 NC_000907.1 hypothetical protein 1571943 950365 HI1498.1 Haemophilus influenzae Rd KW20 hypothetical protein NP_439648.1 1571635 D 71421 CDS NP_439649.1 16273401 950366 1571955..1572524 1 NC_000907.1 hypothetical protein 1572524 950366 HI1499 Haemophilus influenzae Rd KW20 hypothetical protein NP_439649.1 1571955 D 71421 CDS NP_439650.1 16273402 950367 1572524..1574050 1 NC_000907.1 hypothetical protein 1574050 950367 HI1500 Haemophilus influenzae Rd KW20 hypothetical protein NP_439650.1 1572524 D 71421 CDS NP_439651.1 16273403 950368 1574062..1575624 1 NC_000907.1 hypothetical protein 1575624 950368 HI1501 Haemophilus influenzae Rd KW20 hypothetical protein NP_439651.1 1574062 D 71421 CDS NP_439652.1 16273404 950369 1575715..1576959 1 NC_000907.1 hypothetical protein 1576959 950369 HI1502 Haemophilus influenzae Rd KW20 hypothetical protein NP_439652.1 1575715 D 71421 CDS NP_439653.1 16273405 950371 1577097..1577537 1 NC_000907.1 similar to bacteriophage Mu G-1 protein; SP:Q01261 PID:215535; Mu-like prophage FluMu G protein 1577537 950371 HI1503 Haemophilus influenzae Rd KW20 Mu-like prophage FluMu G protein NP_439653.1 1577097 D 71421 CDS NP_439654.1 16273406 950372 1577768..1578835 1 NC_000907.1 similar to bacteriophage Mu I protein; similar to SP:Q01267 PID:215536; bacteriophage Mu I protein 1578835 950372 HI1504 Haemophilus influenzae Rd KW20 bacteriophage Mu I protein NP_439654.1 1577768 D 71421 CDS NP_439655.1 16273407 950373 1578835..1579761 1 NC_000907.1 hypothetical protein 1579761 950373 HI1505 Haemophilus influenzae Rd KW20 hypothetical protein NP_439655.1 1578835 D 71421 CDS NP_439658.1 16273410 950376 1580232..1580657 1 NC_000907.1 similar to PID:2353778; hypothetical protein 1580657 950376 HI1508 Haemophilus influenzae Rd KW20 hypothetical protein NP_439658.1 1580232 D 71421 CDS NP_439659.2 30995454 950377 1580657..1581208 1 NC_000907.1 similar to PID:2353777; hypothetical protein 1581208 950377 HI1509 Haemophilus influenzae Rd KW20 hypothetical protein NP_439659.2 1580657 D 71421 CDS NP_439660.1 16273412 950834 1581221..1581412 1 NC_000907.1 similar to PID:1834290; hypothetical protein 1581412 950834 HI1510 Haemophilus influenzae Rd KW20 hypothetical protein NP_439660.1 1581221 D 71421 CDS NP_439661.1 16273413 950573 1581412..1582875 1 NC_000907.1 similar to bacteriophage Mu L protein; PID:1834291; sheath protein gpL 1582875 950573 HI1511 Haemophilus influenzae Rd KW20 sheath protein gpL NP_439661.1 1581412 D 71421 CDS NP_439662.1 16273414 950378 1582885..1583241 1 NC_000907.1 similar to PID:1834292; hypothetical protein 1583241 950378 HI1512 Haemophilus influenzae Rd KW20 hypothetical protein NP_439662.1 1582885 D 71421 CDS NP_439663.1 16273415 950379 1583254..1583637 1 NC_000907.1 similar to PID:1834293; hypothetical protein 1583637 950379 HI1513 Haemophilus influenzae Rd KW20 hypothetical protein NP_439663.1 1583254 D 71421 CDS NP_439664.1 16273416 950380 1583718..1585613 1 NC_000907.1 monofunctional biosynthetic peptidoglycan transglycosylase 1585613 950380 HI1514 Haemophilus influenzae Rd KW20 monofunctional biosynthetic peptidoglycan transglycosylase NP_439664.1 1583718 D 71421 CDS NP_439665.1 16273417 950381 1585613..1586980 1 NC_000907.1 similar to SP:P08557 PID:15105; 64 kDa virion protein 1586980 muN 950381 muN Haemophilus influenzae Rd KW20 64 kDa virion protein NP_439665.1 1585613 D 71421 CDS NP_439667.1 16273418 950383 1588277..1588825 1 NC_000907.1 hypothetical protein 1588825 950383 HI1518 Haemophilus influenzae Rd KW20 hypothetical protein NP_439667.1 1588277 D 71421 CDS NP_439668.1 16273419 950384 1588834..1589241 1 NC_000907.1 hypothetical protein 1589241 950384 HI1519 Haemophilus influenzae Rd KW20 hypothetical protein NP_439668.1 1588834 D 71421 CDS NP_439669.1 16273420 950385 1589241..1590308 1 NC_000907.1 similar to GB:U00096 PID:1787398; hypothetical protein 1590308 950385 HI1520 Haemophilus influenzae Rd KW20 hypothetical protein NP_439669.1 1589241 D 71421 CDS NP_439670.2 30995455 950386 1590340..1590900 1 NC_000907.1 similar to GB:U00096 PID:1787399; hypothetical protein 1590900 950386 HI1521 Haemophilus influenzae Rd KW20 hypothetical protein NP_439670.2 1590340 D 71421 CDS NP_439671.1 16273422 950387 1590900..1592771 1 NC_000907.1 hypothetical protein 1592771 950387 HI1522 Haemophilus influenzae Rd KW20 hypothetical protein NP_439671.1 1590900 D 71421 CDS NP_439672.1 16273423 950388 1593255..1593374 1 NC_000907.1 hypothetical protein 1593374 950388 HI1522.1 Haemophilus influenzae Rd KW20 hypothetical protein NP_439672.1 1593255 D 71421 CDS NP_439673.1 16273424 949672 1593385..1594275 1 NC_000907.1 hypothetical protein 1594275 949672 HI1523 Haemophilus influenzae Rd KW20 hypothetical protein NP_439673.1 1593385 D 71421 CDS NP_439674.1 16273425 950823 complement(1594829..1595566) 1 NC_000907.1 similar to GB:AE000666; molybdate-binding periplasmic protein 1595566 950823 HI1525 Haemophilus influenzae Rd KW20 molybdate-binding periplasmic protein NP_439674.1 1594829 R 71421 CDS NP_439675.1 16273426 949890 complement(1595753..1597183) 1 NC_000907.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 1597183 rfaE 949890 rfaE Haemophilus influenzae Rd KW20 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase NP_439675.1 1595753 R 71421 CDS NP_439676.2 30995456 950389 1597280..1598215 1 NC_000907.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 1598215 htrB 950389 htrB Haemophilus influenzae Rd KW20 lipid A biosynthesis lauroyl acyltransferase NP_439676.2 1597280 D 71421 CDS NP_439677.1 16273428 950390 1598289..1600187 1 NC_000907.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 1600187 parE 950390 parE Haemophilus influenzae Rd KW20 DNA topoisomerase IV subunit B NP_439677.1 1598289 D 71421 CDS NP_439678.1 16273429 950391 1600254..1602497 1 NC_000907.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 1602497 parC 950391 parC Haemophilus influenzae Rd KW20 DNA topoisomerase IV subunit A NP_439678.1 1600254 D 71421 CDS NP_439679.1 16273430 950392 1602539..1603753 1 NC_000907.1 similar to GB:L10328 SP:P19933 GB:D00626 GB:X17499 PID:216541; glutamate permease 1603753 gltS 950392 gltS Haemophilus influenzae Rd KW20 glutamate permease NP_439679.1 1602539 D 71421 CDS NP_439680.1 16273431 950393 complement(1603792..1604700) 1 NC_000907.1 similar to SP:P17116 GB:X15859 PID:42747 GB:U00096 PID:1651386; ribosomal protein S6 modification protein 1604700 rimK 950393 rimK Haemophilus influenzae Rd KW20 ribosomal protein S6 modification protein NP_439680.1 1603792 R 71421 CDS NP_439681.1 16273432 950394 1604817..1605080 1 NC_000907.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 1605080 grxA 950394 grxA Haemophilus influenzae Rd KW20 glutaredoxin NP_439681.1 1604817 D 71421 CDS NP_439682.1 16273433 950395 complement(1605147..1606367) 1 NC_000907.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1606367 fabB 950395 fabB Haemophilus influenzae Rd KW20 3-oxoacyl-ACP synthase NP_439682.1 1605147 R 71421 CDS NP_439686.1 16273437 950399 1608780..1609583 1 NC_000907.1 similar to GB:M27280 SP:P14181 GB:M37912 PID:1574379; lic-1 operon protein 1609583 licA 950399 licA Haemophilus influenzae Rd KW20 lic-1 operon protein NP_439686.1 1608780 D 71421 CDS NP_439687.1 16273438 950400 1609583..1610461 1 NC_000907.1 similar to GB:M27280 SP:P14182; lic-1 operon protein 1610461 licB 950400 licB Haemophilus influenzae Rd KW20 lic-1 operon protein NP_439687.1 1609583 D 71421 CDS NP_439688.1 16273439 950402 1610458..1611159 1 NC_000907.1 similar to GB:M27280 SP:P14183; lic-1 operon protein 1611159 licC 950402 licC Haemophilus influenzae Rd KW20 lic-1 operon protein NP_439688.1 1610458 D 71421 CDS NP_439689.1 16273440 950403 1611159..1611956 1 NC_000907.1 similar to GB:M27280 SP:P14184; lic-1 operon protein 1611956 licD 950403 licD Haemophilus influenzae Rd KW20 lic-1 operon protein NP_439689.1 1611159 D 71421 CDS NP_439690.1 16273441 950404 complement(1611994..1613841) 1 NC_000907.1 similar to GB:M13359 SP:P08395 GB:U13772 GB:U13773 GB:U13774; protease IV 1613841 sppA 950404 sppA Haemophilus influenzae Rd KW20 protease IV NP_439690.1 1611994 R 71421 CDS NP_439691.1 16273442 950405 1613939..1614493 1 NC_000907.1 similar to PID:2253239; hypothetical protein 1614493 950405 HI1542 Haemophilus influenzae Rd KW20 hypothetical protein NP_439691.1 1613939 D 71421 CDS NP_439692.1 16273443 950406 complement(1614541..1615095) 1 NC_000907.1 similar to GB:U00096 SP:P75915 PID:1787272; anaerobic dehydrogenase subunit 1615095 950406 HI1543 Haemophilus influenzae Rd KW20 anaerobic dehydrogenase subunit NP_439692.1 1614541 R 71421 CDS NP_439693.1 16273444 950407 complement(1615095..1615703) 1 NC_000907.1 similar to SP:Q64669 PID:595518; NAD(P)H oxidoreductase 1615703 950407 HI1544 Haemophilus influenzae Rd KW20 NAD(P)H oxidoreductase NP_439693.1 1615095 R 71421 CDS NP_439694.1 16273445 950408 complement(1615824..1617068) 1 NC_000907.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 1617068 950408 HI1545 Haemophilus influenzae Rd KW20 serine/threonine transporter SstT NP_439694.1 1615824 R 71421 CDS NP_439695.1 16273446 950409 1617353..1617775 1 NC_000907.1 hypothetical protein 1617775 950409 HI1546 Haemophilus influenzae Rd KW20 hypothetical protein NP_439695.1 1617353 D 71421 CDS NP_439696.1 16273447 950411 complement(1617864..1618952) 1 NC_000907.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1618952 aroG 950411 aroG Haemophilus influenzae Rd KW20 phospho-2-dehydro-3-deoxyheptonate aldolase NP_439696.1 1617864 R 71421 CDS NP_439697.1 16273448 950412 complement(1619170..1620420) 1 NC_000907.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1620420 950412 HI1548 Haemophilus influenzae Rd KW20 outer membrane-specific lipoprotein transporter subunit LolE NP_439697.1 1619170 R 71421 CDS NP_439698.1 16273449 950413 complement(1620420..1621103) 1 NC_000907.1 similar to GB:U00096 SP:P75957 PID:1787361; ABC transporter ATP-binding protein 1621103 950413 HI1549 Haemophilus influenzae Rd KW20 ABC transporter ATP-binding protein NP_439698.1 1620420 R 71421 CDS NP_439699.1 16273450 950414 complement(1621250..1621825) 1 NC_000907.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 1621825 bioD 950414 bioD Haemophilus influenzae Rd KW20 dithiobiotin synthetase NP_439699.1 1621250 R 71421 CDS NP_439700.1 16273451 950415 complement(1621835..1622617) 1 NC_000907.1 similar to GB:J04423 SP:P12999 PID:145427 PID:490221 GB:U00096; biotin synthase 1622617 950415 HI1551 Haemophilus influenzae Rd KW20 biotin synthase NP_439700.1 1621835 R 71421 CDS NP_439701.1 16273452 950563 complement(1622605..1623252) 1 NC_000907.1 hypothetical protein 1623252 950563 HI1552 Haemophilus influenzae Rd KW20 hypothetical protein NP_439701.1 1622605 R 71421 CDS NP_439702.1 16273453 950334 complement(1623262..1624404) 1 NC_000907.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 1624404 bioF 950334 bioF Haemophilus influenzae Rd KW20 8-amino-7-oxononanoate synthase NP_439702.1 1623262 R 71421 CDS NP_439703.1 16273454 950608 complement(1624413..1625705) 1 NC_000907.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine--8-amino-7-oxononanoate transaminase 1625705 bioA 950608 bioA Haemophilus influenzae Rd KW20 adenosylmethionine--8-amino-7-oxononanoate transaminase NP_439703.1 1624413 R 71421 CDS NP_439704.1 16273455 949639 complement(1625724..1626905) 1 NC_000907.1 similar to GB:U00096 SP:P75956 PID:1787360; hypothetical protein 1626905 949639 HI1555 Haemophilus influenzae Rd KW20 hypothetical protein NP_439704.1 1625724 R 71421 CDS NP_439705.1 16273456 950416 complement(1626905..1627852) 1 NC_000907.1 Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor; glycerate dehydrogenase 1627852 950416 HI1556 Haemophilus influenzae Rd KW20 glycerate dehydrogenase NP_439705.1 1626905 R 71421 CDS NP_439706.1 16273457 950417 complement(1627912..1628766) 1 NC_000907.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1628766 kdsA 950417 kdsA Haemophilus influenzae Rd KW20 2-dehydro-3-deoxyphosphooctonate aldolase NP_439706.1 1627912 R 71421 CDS NP_439707.1 16273458 950418 complement(1628781..1629584) 1 NC_000907.1 similar to SP:P20101 GB:X05552 PID:41872 PID:1008040 GB:U00096; hypothetical protein 1629584 950418 HI1558 Haemophilus influenzae Rd KW20 hypothetical protein NP_439707.1 1628781 R 71421 CDS NP_439708.1 16273459 950419 complement(1629584..1630462) 1 NC_000907.1 similar to GB:D28567 SP:P37186 PID:466533 PID:968931 GB:U00096; hypothetical protein 1630462 hemK 950419 hemK Haemophilus influenzae Rd KW20 hypothetical protein NP_439708.1 1629584 R 71421 CDS NP_439709.1 16273460 950420 complement(1630462..1630932) 1 NC_000907.1 hypothetical protein 1630932 950420 HI1560 Haemophilus influenzae Rd KW20 hypothetical protein NP_439709.1 1630462 R 71421 CDS NP_439710.1 16273461 950421 complement(1630955..1632040) 1 NC_000907.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1632040 prfA 950421 prfA Haemophilus influenzae Rd KW20 peptide chain release factor 1 NP_439710.1 1630955 R 71421 CDS NP_439712.1 16273463 950423 complement(1632558..1633094) 1 NC_000907.1 similar to GB:U00096 PID:1788666; hypothetical protein 1633094 950423 HI1563 Haemophilus influenzae Rd KW20 hypothetical protein NP_439712.1 1632558 R 71421 CDS NP_439713.1 16273464 950424 complement(1633127..1633279) 1 NC_000907.1 hypothetical protein 1633279 950424 HI1564 Haemophilus influenzae Rd KW20 hypothetical protein NP_439713.1 1633127 R 71421 CDS NP_439715.1 16273465 950426 complement(1636791..1637207) 1 NC_000907.1 similar to bacteriophage Mu G-2 protein; SP:Q01261 PID:215535; Mu-like prophage FluMu G protein 1637207 950426 HI1568 Haemophilus influenzae Rd KW20 Mu-like prophage FluMu G protein NP_439715.1 1636791 R 71421 CDS NP_439717.1 16273467 950428 complement(1638049..1638288) 1 NC_000907.1 hypothetical protein 1638288 950428 HI1571 Haemophilus influenzae Rd KW20 hypothetical protein NP_439717.1 1638049 R 71421 CDS NP_439719.1 16273468 950433 1640232..1641668 1 NC_000907.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1641668 pykA 950433 pykA Haemophilus influenzae Rd KW20 pyruvate kinase NP_439719.1 1640232 D 71421 CDS NP_439720.1 16273469 950434 1641702..1643216 1 NC_000907.1 unwinds double stranded DNA; replicative DNA helicase 1643216 dnaB 950434 dnaB Haemophilus influenzae Rd KW20 replicative DNA helicase NP_439720.1 1641702 D 71421 CDS NP_439721.1 16273470 950435 1643226..1644308 1 NC_000907.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 1644308 alr 950435 alr Haemophilus influenzae Rd KW20 alanine racemase NP_439721.1 1643226 D 71421 CDS NP_439722.2 161350019 950436 1644405..1646054 1 NC_000907.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 1646054 pgi 950436 pgi Haemophilus influenzae Rd KW20 glucose-6-phosphate isomerase NP_439722.2 1644405 D 71421 CDS NP_439724.1 16273473 950438 1646702..1647673 1 NC_000907.1 similar to PID:595813; glycosyl transferase 1647673 950438 HI1578 Haemophilus influenzae Rd KW20 glycosyl transferase NP_439724.1 1646702 D 71421 CDS NP_439725.1 16273474 950439 complement(1647856..1648323) 1 NC_000907.1 similar to GB:M18877 SP:P10325; 15 kDa peptidoglycan-associated lipoprotein 1648323 lpp 950439 lpp Haemophilus influenzae Rd KW20 15 kDa peptidoglycan-associated lipoprotein NP_439725.1 1647856 R 71421 CDS NP_439728.1 16273477 950446 1649297..1651030 1 NC_000907.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1651030 argS 950446 argS Haemophilus influenzae Rd KW20 arginyl-tRNA synthetase NP_439728.1 1649297 D 71421 CDS NP_439729.1 16273478 950447 complement(1651323..1651814) 1 NC_000907.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 1651814 ilvH 950447 ilvH Haemophilus influenzae Rd KW20 acetolactate synthase 3 regulatory subunit NP_439729.1 1651323 R 71421 CDS NP_439730.1 16273479 950449 complement(1651814..1653535) 1 NC_000907.1 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 3 catalytic subunit 1653535 ilvI 950449 ilvI Haemophilus influenzae Rd KW20 acetolactate synthase 3 catalytic subunit NP_439730.1 1651814 R 71421 CDS NP_439731.1 16273480 950450 complement(1653802..1655361) 1 NC_000907.1 similar to GB:AE000511 PID:2314087; isoleucyl-tRNA synthetase 1655361 950450 HI1586 Haemophilus influenzae Rd KW20 isoleucyl-tRNA synthetase NP_439731.1 1653802 R 71421 CDS NP_439732.1 16273481 950451 1655765..1656169 1 NC_000907.1 similar to GB:X07688 SP:P08936 GB:X57231 GB:X59940 GB:X67326; DNA-binding protein H-NS 1656169 hns 950451 hns Haemophilus influenzae Rd KW20 DNA-binding protein H-NS NP_439732.1 1655765 D 71421 CDS NP_439733.1 16273482 950306 1656239..1657075 1 NC_000907.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 1657075 purU 950306 purU Haemophilus influenzae Rd KW20 formyltetrahydrofolate deformylase NP_439733.1 1656239 D 71421 CDS NP_439734.1 16273483 950448 1657075..1658373 1 NC_000907.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1658373 aroA 950448 aroA Haemophilus influenzae Rd KW20 3-phosphoshikimate 1-carboxyvinyltransferase NP_439734.1 1657075 D 71421 CDS NP_439735.1 16273484 950837 complement(1658455..1659795) 1 NC_000907.1 similar to SP:P45526 GB:U00096 PID:1787119; recombination factor protein RarA 1659795 950837 HI1590 Haemophilus influenzae Rd KW20 recombination factor protein RarA NP_439735.1 1658455 R 71421 CDS NP_439736.1 16273485 950452 complement(1659856..1660473) 1 NC_000907.1 participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 1660473 lolA 950452 lolA Haemophilus influenzae Rd KW20 outer-membrane lipoprotein carrier protein NP_439736.1 1659856 R 71421 CDS NP_439738.2 161350018 950361 complement(1663262..1663741) 1 NC_000907.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 1663741 lrp 950361 lrp Haemophilus influenzae Rd KW20 leucine-responsive transcriptional regulator NP_439738.2 1663262 R 71421 CDS NP_439739.2 30995458 950453 complement(1663821..1665197) 1 NC_000907.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 1665197 radA 950453 radA Haemophilus influenzae Rd KW20 DNA repair protein RadA NP_439739.2 1663821 R 71421 CDS NP_439740.1 16273488 950454 complement(1665333..1666391) 1 NC_000907.1 similar to SP:P30871 GB:Z21844 PID:49399 GB:U00096 PID:1789434; hypothetical protein 1666391 950454 HI1598 Haemophilus influenzae Rd KW20 hypothetical protein NP_439740.1 1665333 R 71421 CDS NP_439741.2 30995459 950442 complement(1666703..1667401) 1 NC_000907.1 hypothetical protein 1667401 950442 HI1599 Haemophilus influenzae Rd KW20 hypothetical protein NP_439741.2 1666703 R 71421 CDS NP_439742.1 16273490 950455 complement(1667409..1668362) 1 NC_000907.1 hypothetical protein 1668362 950455 HI1600 Haemophilus influenzae Rd KW20 hypothetical protein NP_439742.1 1667409 R 71421 CDS NP_439743.1 16273491 950456 complement(1668392..1668679) 1 NC_000907.1 hypothetical protein 1668679 950456 HI1601 Haemophilus influenzae Rd KW20 hypothetical protein NP_439743.1 1668392 R 71421 CDS NP_439744.2 30995460 950457 complement(1668718..1669158) 1 NC_000907.1 hypothetical protein 1669158 950457 HI1602 Haemophilus influenzae Rd KW20 hypothetical protein NP_439744.2 1668718 R 71421 CDS NP_439745.1 16273493 950838 1669381..1670061 1 NC_000907.1 similar to GB:AE000782; phosphate transport regulator 1670061 950838 HI1603 Haemophilus influenzae Rd KW20 phosphate transport regulator NP_439745.1 1669381 D 71421 CDS NP_439746.1 16273494 950410 1670086..1671348 1 NC_000907.1 similar to PID:1814405; phosphate permease 1671348 950410 HI1604 Haemophilus influenzae Rd KW20 phosphate permease NP_439746.1 1670086 D 71421 CDS NP_439747.1 16273495 950458 1671414..1672025 1 NC_000907.1 similar to SP:P39202 PID:1203798 GB:U00096 PID:1789435; hypothetical protein 1672025 950458 HI1605 Haemophilus influenzae Rd KW20 hypothetical protein NP_439747.1 1671414 D 71421 CDS NP_439748.1 16273496 950839 1672032..1673282 1 NC_000907.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 1673282 cca 950839 cca Haemophilus influenzae Rd KW20 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase NP_439748.1 1672032 D 71421 CDS NP_439749.1 16273497 950296 1673345..1673974 1 NC_000907.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB 1673974 lolB 950296 lolB Haemophilus influenzae Rd KW20 outer membrane lipoprotein LolB NP_439749.1 1673345 D 71421 CDS NP_439750.1 16273498 950459 1673986..1674927 1 NC_000907.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1674927 ipk 950459 ipk Haemophilus influenzae Rd KW20 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase NP_439750.1 1673986 D 71421 CDS NP_439751.1 16273499 950463 1674929..1675876 1 NC_000907.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1675876 prsA 950463 prsA Haemophilus influenzae Rd KW20 ribose-phosphate pyrophosphokinase NP_439751.1 1674929 D 71421 CDS NP_439752.1 16273500 950464 complement(1675940..1677145) 1 NC_000907.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1677145 tyrS 950464 tyrS Haemophilus influenzae Rd KW20 tyrosyl-tRNA synthetase NP_439752.1 1675940 R 71421 CDS NP_439753.1 16273501 950840 complement(1677346..1678062) 1 NC_000907.1 Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A 1678062 sfsA 950840 sfsA Haemophilus influenzae Rd KW20 sugar fermentation stimulation protein A NP_439753.1 1677346 R 71421 CDS NP_439754.1 16273502 950466 complement(1678071..1679465) 1 NC_000907.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1679465 950466 HI1612 Haemophilus influenzae Rd KW20 multidrug efflux protein NP_439754.1 1678071 R 71421 CDS NP_439755.1 16273503 950465 1679509..1680123 1 NC_000907.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1680123 ribE 950465 ribE Haemophilus influenzae Rd KW20 riboflavin synthase subunit alpha NP_439755.1 1679509 D 71421 CDS NP_439756.1 16273504 950613 complement(1680195..1682804) 1 NC_000907.1 similar to GB:M15273 SP:P04825 GB:M15676 GB:X04020 PID:147142; aminopeptidase N 1682804 pepN 950613 pepN Haemophilus influenzae Rd KW20 aminopeptidase N NP_439756.1 1680195 R 71421 CDS NP_439757.1 16273505 949616 1682965..1683459 1 NC_000907.1 Catalyzes a step in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase catalytic subunit 1683459 purE 949616 purE Haemophilus influenzae Rd KW20 phosphoribosylaminoimidazole carboxylase catalytic subunit NP_439757.1 1682965 D 71421 CDS NP_439758.1 16273506 950468 1683529..1684617 1 NC_000907.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 1684617 purK 950468 purK Haemophilus influenzae Rd KW20 phosphoribosylaminoimidazole carboxylase ATPase subunit NP_439758.1 1683529 D 71421 CDS NP_439759.1 16273507 950841 1684756..1685946 1 NC_000907.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 1685946 aspC 950841 aspC Haemophilus influenzae Rd KW20 aromatic amino acid aminotransferase NP_439759.1 1684756 D 71421 CDS NP_439760.2 30995461 950842 complement(1686173..1686790) 1 NC_000907.1 similar to GB:AE000666; ABC transporter ATP-binding protein 1686790 950842 HI1618 Haemophilus influenzae Rd KW20 ABC transporter ATP-binding protein NP_439760.2 1686173 R 71421 CDS NP_439763.1 16273510 950848 complement(1687425..1688045) 1 NC_000907.1 catalyzes the ATP-dependent transport of cobalt; cobalt transport protein CbiM 1688045 950848 HI1621 Haemophilus influenzae Rd KW20 cobalt transport protein CbiM NP_439763.1 1687425 R 71421 CDS NP_439764.1 16273511 950474 complement(1688045..1688530) 1 NC_000907.1 hypothetical protein 1688530 950474 HI1622 Haemophilus influenzae Rd KW20 hypothetical protein NP_439764.1 1688045 R 71421 CDS NP_439765.1 16273512 950470 complement(1688543..1689226) 1 NC_000907.1 branched chain amino acid ABC transporter substrate-binding protein 1689226 950470 HI1624 Haemophilus influenzae Rd KW20 branched chain amino acid ABC transporter substrate-binding protein NP_439765.1 1688543 R 71421 CDS NP_439766.1 16273513 950843 1689316..1689723 1 NC_000907.1 similar to GB:X57326 PID:48151; mercuric resistance operon regulatory protein 1689723 merR2 950843 merR2 Haemophilus influenzae Rd KW20 mercuric resistance operon regulatory protein NP_439766.1 1689316 D 71421 CDS NP_439767.1 16273514 950478 complement(1689783..1690280) 1 NC_000907.1 hypothetical protein 1690280 950478 HI1625 Haemophilus influenzae Rd KW20 hypothetical protein NP_439767.1 1689783 R 71421 CDS NP_439768.1 16273515 950846 complement(1690281..1690997) 1 NC_000907.1 similar to SP:P46909 PID:971339 GB:AL009126; hypothetical protein 1690997 950846 HI1626 Haemophilus influenzae Rd KW20 hypothetical protein NP_439768.1 1690281 R 71421 CDS NP_439769.1 16273516 950462 1691109..1691459 1 NC_000907.1 similar to PID:2407234; hypothetical protein 1691459 950462 HI1627 Haemophilus influenzae Rd KW20 hypothetical protein NP_439769.1 1691109 D 71421 CDS NP_439770.1 16273517 950472 1691490..1691894 1 NC_000907.1 similar to SP:P39436 PID:606172 GB:U00096 PID:1789628; hypothetical protein 1691894 950472 HI1628 Haemophilus influenzae Rd KW20 hypothetical protein NP_439770.1 1691490 D 71421 CDS NP_439771.2 30995462 950844 complement(1691957..1692544) 1 NC_000907.1 similar to GB:M68934 SP:P09548 GB:X02743 PID:146363 GB:U00096; hypothetical protein 1692544 950844 HI1629 Haemophilus influenzae Rd KW20 hypothetical protein NP_439771.2 1691957 R 71421 CDS NP_439772.1 16273519 950473 1692762..1693049 1 NC_000907.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 1693049 rpL25 950473 rpL25 Haemophilus influenzae Rd KW20 50S ribosomal protein L25 NP_439772.1 1692762 D 71421 CDS NP_439773.1 16273520 950845 complement(1693148..1693720) 1 NC_000907.1 hypothetical protein 1693720 950845 HI1631 Haemophilus influenzae Rd KW20 hypothetical protein NP_439773.1 1693148 R 71421 CDS NP_439774.1 16273521 950850 1694577..1694942 1 NC_000907.1 hypothetical protein 1694942 950850 HI1632 Haemophilus influenzae Rd KW20 hypothetical protein NP_439774.1 1694577 D 71421 CDS NP_439775.1 16273522 950476 1695071..1696369 1 NC_000907.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 1696369 purA 950476 purA Haemophilus influenzae Rd KW20 adenylosuccinate synthetase NP_439775.1 1695071 D 71421 CDS NP_439776.2 30995463 950847 complement(1696426..1697253) 1 NC_000907.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 1697253 dapD 950847 dapD Haemophilus influenzae Rd KW20 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase NP_439776.2 1696426 R 71421 CDS NP_439777.1 16273524 950319 1697612..1698622 1 NC_000907.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 1698622 purR 950319 purR Haemophilus influenzae Rd KW20 DNA-binding transcriptional repressor PurR NP_439777.1 1697612 D 71421 CDS NP_439778.1 16273525 950481 1698805..1701444 1 NC_000907.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 1701444 ppc 950481 ppc Haemophilus influenzae Rd KW20 phosphoenolpyruvate carboxylase NP_439778.1 1698805 D 71421 CDS NP_439779.1 16273526 950851 complement(1701481..1702893) 1 NC_000907.1 similar to GB:U00096 PID:1787581; hypothetical protein 1702893 950851 HI1637 Haemophilus influenzae Rd KW20 hypothetical protein NP_439779.1 1701481 R 71421 CDS NP_439780.1 16273527 950479 1702963..1704660 1 NC_000907.1 similar to SP:P36634 GB:X52093 GB:X74212 PID:414208; anti peptide resistance ABC transporter substrate-binding protein 1704660 sapA 950479 sapA Haemophilus influenzae Rd KW20 anti peptide resistance ABC transporter substrate-binding protein NP_439780.1 1702963 D 71421 CDS NP_439781.1 16273528 950849 1704660..1705625 1 NC_000907.1 similar to SP:P36668 GB:X52093 GB:X74212 PID:414209; peptide ABC transporter permease 1705625 sapB 950849 sapB Haemophilus influenzae Rd KW20 peptide ABC transporter permease NP_439781.1 1704660 D 71421 CDS NP_439782.1 16273529 950835 1705615..1706502 1 NC_000907.1 similar to SP:P36669 GB:X74212 PID:414210; peptide ABC transporter permease 1706502 sapC 950835 sapC Haemophilus influenzae Rd KW20 peptide ABC transporter permease NP_439782.1 1705615 D 71421 CDS NP_439783.1 16273530 950483 1706506..1707555 1 NC_000907.1 similar to SP:P36636 GB:X74212 PID:414211; peptide ABC transporter ATP-binding protein 1707555 sapD 950483 sapD Haemophilus influenzae Rd KW20 peptide ABC transporter ATP-binding protein NP_439783.1 1706506 D 71421 CDS NP_439784.1 16273531 950853 1707555..1708364 1 NC_000907.1 similar to SP:P36637 GB:U08190 PID:470683 GB:U00096 PID:1279404; anti peptide resistance ABC transporter ATPase 1708364 sapF 950853 sapF Haemophilus influenzae Rd KW20 anti peptide resistance ABC transporter ATPase NP_439784.1 1707555 D 71421 CDS NP_439785.1 16273532 950484 1708376..1709392 1 NC_000907.1 similar to SP:P33019 PID:405879 GB:U00096 PID:1788482; hypothetical protein 1709392 950484 HI1643 Haemophilus influenzae Rd KW20 hypothetical protein NP_439785.1 1708376 D 71421 CDS NP_439786.1 16273533 950487 complement(1709484..1710293) 1 NC_000907.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1710293 truA 950487 truA Haemophilus influenzae Rd KW20 tRNA pseudouridine synthase A NP_439786.1 1709484 R 71421 CDS NP_439787.1 16273534 950852 1710527..1711528 1 NC_000907.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 1711528 fbp 950852 fbp Haemophilus influenzae Rd KW20 fructose-1,6-bisphosphatase NP_439787.1 1710527 D 71421 CDS NP_439788.1 16273655 950485 complement(1711447..1712115) 1 NC_000907.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1712115 cmk 950485 cmk Haemophilus influenzae Rd KW20 cytidylate kinase NP_439788.1 1711447 R 71421 CDS NP_439789.1 16273535 950488 1712590..1713465 1 NC_000907.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 1713465 950488 HI1647 Haemophilus influenzae Rd KW20 pyridoxal biosynthesis lyase PdxS NP_439789.1 1712590 D 71421 CDS NP_439790.2 30995464 950854 1713466..1714044 1 NC_000907.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 1714044 950854 HI1648 Haemophilus influenzae Rd KW20 glutamine amidotransferase subunit PdxT NP_439790.2 1713466 D 71421 CDS NP_439791.1 16273537 950490 complement(1714592..1716286) 1 NC_000907.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 1716286 dld 950490 dld Haemophilus influenzae Rd KW20 D-lactate dehydrogenase NP_439791.1 1714592 R 71421 CDS NP_439792.1 16273538 950489 1716547..1716657 1 NC_000907.1 hypothetical protein 1716657 950489 HI1650 Haemophilus influenzae Rd KW20 hypothetical protein NP_439792.1 1716547 D 71421 CDS NP_439793.1 16273539 950855 complement(1716772..1717050) 1 NC_000907.1 nucleotide sequence similar to HI0220; hypothetical protein 1717050 950855 HI1651 Haemophilus influenzae Rd KW20 hypothetical protein NP_439793.1 1716772 R 71421 CDS NP_439794.1 16273540 950494 complement(1717801..1718352) 1 NC_000907.1 similar to GB:U00096 SP:P77685 PID:1498150 PID:1736840 PID:1788501; lipoprotein 1718352 spr 950494 spr Haemophilus influenzae Rd KW20 lipoprotein NP_439794.1 1717801 R 71421 CDS NP_439795.2 30995465 950857 complement(join(1718465..1718884,1718884..1719912)) 1 NC_000907.1 similar to Zn-dependent protease; this region contains an authentic frame shift and is not the result of a sequencing artifact; similar to SP:P46473 PID:606183 GB:U00096 PID:1732437 PID:1789640; hypothetical protein 1719912 tldD 950857 tldD Haemophilus influenzae Rd KW20 hypothetical protein NP_439795.2 1718465 R 71421 CDS NP_439796.1 16273541 950491 complement(1720014..1720865) 1 NC_000907.1 similar to SP:P45528 PID:606086 GB:U00096 PID:1789535; hypothetical protein 1720865 950491 HI1654 Haemophilus influenzae Rd KW20 hypothetical protein NP_439796.1 1720014 R 71421 CDS NP_439797.1 16273542 950219 1720937..1722664 1 NC_000907.1 similar to PID:1353671; antigen 1722664 950219 HI1655 Haemophilus influenzae Rd KW20 antigen NP_439797.1 1720937 D 71421 CDS NP_439798.1 16273543 950807 1722664..1723023 1 NC_000907.1 similar to SP:P45465 PID:606088 GB:U00096 PID:1789538; hypothetical protein 1723023 950807 HI1656 Haemophilus influenzae Rd KW20 hypothetical protein NP_439798.1 1722664 D 71421 CDS NP_439799.1 16273544 950796 1723036..1723620 1 NC_000907.1 similar to SP:P45466 PID:606089 GB:U00096 PID:1789539; hypothetical protein 1723620 950796 HI1657 Haemophilus influenzae Rd KW20 hypothetical protein NP_439799.1 1723036 D 71421 CDS NP_439800.1 16273545 950803 1723677..1724258 1 NC_000907.1 similar to SP:P45467 PID:606090 GB:U00096 PID:1789540; hypothetical protein 1724258 950803 HI1658 Haemophilus influenzae Rd KW20 hypothetical protein NP_439800.1 1723677 D 71421 CDS NP_439801.2 30995466 950495 1724513..1726783 1 NC_000907.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1726783 nrdA 950495 nrdA Haemophilus influenzae Rd KW20 ribonucleotide-diphosphate reductase subunit alpha NP_439801.2 1724513 D 71421 CDS NP_439802.1 16273547 950858 1726925..1728055 1 NC_000907.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 1728055 nrdB 950858 nrdB Haemophilus influenzae Rd KW20 ribonucleotide-diphosphate reductase subunit beta NP_439802.1 1726925 D 71421 CDS NP_439803.1 16273548 950492 complement(1728171..1729400) 1 NC_000907.1 similar to GB:J01619 SP:P07016 GB:X00664 PID:146202 PID:43022; 2-oxoglutarate dehydrogenase E2 component dihydrolipoamide succinyltransferase 1729400 sucB 950492 sucB Haemophilus influenzae Rd KW20 2-oxoglutarate dehydrogenase E2 component dihydrolipoamide succinyltransferase NP_439803.1 1728171 R 71421 CDS NP_439804.2 30995467 950496 complement(1729503..1732310) 1 NC_000907.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 1732310 sucA 950496 sucA Haemophilus influenzae Rd KW20 2-oxoglutarate dehydrogenase E1 component NP_439804.2 1729503 R 71421 CDS NP_439805.1 16273550 950497 complement(1732513..1733151) 1 NC_000907.1 similar to GB:U00096 SP:P75849 PID:1787158; hypothetical protein 1733151 950497 HI1663 Haemophilus influenzae Rd KW20 hypothetical protein NP_439805.1 1732513 R 71421 CDS NP_439806.2 30995468 950504 complement(1733161..1733916) 1 NC_000907.1 similar to GB:U00089 SP:P78005 PID:1673805; hypothetical protein 1733916 950504 HI1664 Haemophilus influenzae Rd KW20 hypothetical protein NP_439806.2 1733161 R 71421 CDS NP_439809.1 16273554 950498 complement(1734543..1736012) 1 NC_000907.1 similar to SP:P22525 GB:X57550 PID:42044 GB:U00096 PID:1787155; hypothetical protein 1736012 950498 HI1667 Haemophilus influenzae Rd KW20 hypothetical protein NP_439809.1 1734543 R 71421 CDS NP_439810.1 16273555 950859 complement(1736086..1738173) 1 NC_000907.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 1738173 prc 950859 prc Haemophilus influenzae Rd KW20 carboxy-terminal protease NP_439810.1 1736086 R 71421 CDS NP_439812.1 16273557 950501 complement(1738359..1738832) 1 NC_000907.1 affects solute and DNA transport through an unknown mechanism; solute/DNA competence effector 1738832 950501 HI1670 Haemophilus influenzae Rd KW20 solute/DNA competence effector NP_439812.1 1738359 R 71421 CDS NP_439813.1 16273558 950860 1739016..1740266 1 NC_000907.1 similar to GB:U00096 PID:1736474 PID:1736480 PID:1788137; hypothetical protein 1740266 950860 HI1671 Haemophilus influenzae Rd KW20 hypothetical protein NP_439813.1 1739016 D 71421 CDS NP_439814.1 16273559 950502 1740250..1742895 1 NC_000907.1 similar to GB:U00096 PID:1736475 PID:1736481 PID:1788138; hypothetical protein 1742895 950502 HI1672 Haemophilus influenzae Rd KW20 hypothetical protein NP_439814.1 1740250 D 71421 CDS NP_439815.1 16273560 950861 complement(1742950..1743402) 1 NC_000907.1 similar to GB:X70420 SP:P30749 PID:42012 GB:U00096 PID:1787003; molybdopterin converting factor subunit 2 1743402 moaE 950861 moaE Haemophilus influenzae Rd KW20 molybdopterin converting factor subunit 2 NP_439815.1 1742950 R 71421 CDS NP_439816.1 16273561 950503 complement(1743403..1743648) 1 NC_000907.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 1743648 moaD 950503 moaD Haemophilus influenzae Rd KW20 molybdopterin synthase small subunit NP_439816.1 1743403 R 71421 CDS NP_439817.1 16273562 950864 complement(1743650..1744132) 1 NC_000907.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 1744132 moaC 950864 moaC Haemophilus influenzae Rd KW20 molybdenum cofactor biosynthesis protein MoaC NP_439817.1 1743650 R 71421 CDS NP_439818.1 16273563 950505 complement(1744224..1745237) 1 NC_000907.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 1745237 moaA 950505 moaA Haemophilus influenzae Rd KW20 molybdenum cofactor biosynthesis protein A NP_439818.1 1744224 R 71421 CDS NP_439819.1 16273564 950862 1745682..1746353 1 NC_000907.1 Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein 1746353 950862 HI1677 Haemophilus influenzae Rd KW20 iron-sulfur cluster repair di-iron protein NP_439819.1 1745682 D 71421 CDS NP_439820.1 16273565 950863 1746890..1747903 1 NC_000907.1 similar to GB:L19929 SP:P42502 PID:455424; arabinose-5-phosphate isomerase KpsF 1747903 kpsF 950863 kpsF Haemophilus influenzae Rd KW20 arabinose-5-phosphate isomerase KpsF NP_439820.1 1746890 D 71421 CDS NP_439821.1 16273566 950506 1747913..1748455 1 NC_000907.1 forms homotetramers; similar to SP:P45396 PID:606137 GB:U00096 PID:2367202; phosphatase 1748455 yrbI 950506 yrbI Haemophilus influenzae Rd KW20 phosphatase NP_439821.1 1747913 D 71421 CDS NP_439822.1 16273567 950508 complement(1748553..1750709) 1 NC_000907.1 similar to GB:U00096 PID:1787194; hypothetical protein 1750709 950508 HI1680 Haemophilus influenzae Rd KW20 hypothetical protein NP_439822.1 1748553 R 71421 CDS NP_439823.1 16273568 950865 complement(1750777..1751442) 1 NC_000907.1 similar to GB:U00096 PID:1787198; hypothetical protein 1751442 950865 HI1681 Haemophilus influenzae Rd KW20 hypothetical protein NP_439823.1 1750777 R 71421 CDS NP_439824.1 16273569 950509 1751640..1752701 1 NC_000907.1 SohB; periplasmic protein; member of the peptidase S49 family; protease 1752701 sohB 950509 sohB Haemophilus influenzae Rd KW20 protease NP_439824.1 1751640 D 71421 CDS NP_439825.1 16273570 950867 1752983..1753561 1 NC_000907.1 similar to rnfA/rnfE proteins; similar to GB:U00096 PID:1787914; Na(+)-translocating NADH-quinone reductase subunit E 1753561 950867 HI1683 Haemophilus influenzae Rd KW20 Na(+)-translocating NADH-quinone reductase subunit E NP_439825.1 1752983 D 71421 CDS NP_439826.1 16273571 950511 1753649..1754230 1 NC_000907.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 1754230 950511 HI1684 Haemophilus influenzae Rd KW20 electron transport complex protein RnfB NP_439826.1 1753649 D 71421 CDS NP_439827.1 16273572 950866 1754231..1756690 1 NC_000907.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 1756690 950866 HI1685 Haemophilus influenzae Rd KW20 electron transport complex protein RnfC NP_439827.1 1754231 D 71421 CDS NP_439828.1 16273573 950513 1756695..1757771 1 NC_000907.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 1757771 rnfD 950513 rnfD Haemophilus influenzae Rd KW20 electron transport complex protein RnfD NP_439828.1 1756695 D 71421 CDS NP_439829.1 16273574 950514 1757771..1758394 1 NC_000907.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 1758394 rnfG 950514 rnfG Haemophilus influenzae Rd KW20 electron transport complex protein RnfG NP_439829.1 1757771 D 71421 CDS NP_439830.1 16273575 950516 1758396..1759103 1 NC_000907.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex RsxE subunit 1759103 950516 HI1688 Haemophilus influenzae Rd KW20 electron transport complex RsxE subunit NP_439830.1 1758396 D 71421 CDS NP_439831.1 16273576 950507 1759288..1759923 1 NC_000907.1 similar to GB:J02857 SP:P20625 PID:146972 GB:U00096 PID:1742691; endonuclease III 1759923 nth 950507 nth Haemophilus influenzae Rd KW20 endonuclease III NP_439831.1 1759288 D 71421 CDS NP_439832.1 16273577 950500 1759981..1761354 1 NC_000907.1 similar to GB:AL009126; sodium-dependent transporter 1761354 950500 HI1690 Haemophilus influenzae Rd KW20 sodium-dependent transporter NP_439832.1 1759981 D 71421 CDS NP_439833.1 16273578 950518 complement(1761378..1762433) 1 NC_000907.1 Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 1762433 modC 950518 modC Haemophilus influenzae Rd KW20 molybdate transporter ATP-binding protein NP_439833.1 1761378 R 71421 CDS NP_439834.1 16273579 949953 complement(1762420..1763109) 1 NC_000907.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 1763109 modB 949953 modB Haemophilus influenzae Rd KW20 molybdate ABC transporter permease NP_439834.1 1762420 R 71421 CDS NP_439835.1 16273580 950605 complement(1763283..1764047) 1 NC_000907.1 similar to GB:L34009 SP:P37329 PID:504498 PID:973214 PID:1147817; molybdenum ABC transporter substrate-binding protein 1764047 modA 950605 modA Haemophilus influenzae Rd KW20 molybdenum ABC transporter substrate-binding protein NP_439835.1 1763283 R 71421 CDS NP_439836.1 16273581 950754 1764185..1764952 1 NC_000907.1 similar to PID:1002825 SP:P46930 GB:U00096 PID:1147816 PID:1786976; molybdenum transport protein 1764952 modE 950754 modE Haemophilus influenzae Rd KW20 molybdenum transport protein NP_439836.1 1764185 D 71421 CDS NP_439837.2 30995469 950753 complement(1765061..1765846) 1 NC_000907.1 similar to PID:600434 SP:Q46635; UDP-galactose--lipooligosaccharide galactosyltransferase 1765846 950753 HI1695 Haemophilus influenzae Rd KW20 UDP-galactose--lipooligosaccharide galactosyltransferase NP_439837.2 1765061 R 71421 CDS NP_439838.1 16273583 950519 complement(1765866..1766750) 1 NC_000907.1 similar to PID:1944156; lipopolysaccharide biosynthesis protein 1766750 950519 HI1696 Haemophilus influenzae Rd KW20 lipopolysaccharide biosynthesis protein NP_439838.1 1765866 R 71421 CDS NP_439839.1 16273584 950869 complement(1766762..1767535) 1 NC_000907.1 similar to GB:U05670; UDP-GlcNAc--lipooligosaccharide N-acetylglucosaminyl glycosyltransferase 1767535 950869 HI1697 Haemophilus influenzae Rd KW20 UDP-GlcNAc--lipooligosaccharide N-acetylglucosaminyl glycosyltransferase NP_439839.1 1766762 R 71421 CDS NP_439840.1 16273585 950521 complement(1767547..1768608) 1 NC_000907.1 similar to PID:633695; lipopolysaccharide biosynthesis protein 1768608 950521 HI1698 Haemophilus influenzae Rd KW20 lipopolysaccharide biosynthesis protein NP_439840.1 1767547 R 71421 CDS NP_439841.1 16273586 950520 complement(1768610..1769524) 1 NC_000907.1 similar to PID:1546004; lipopolysaccharide biosynthesis protein 1769524 950520 HI1699 Haemophilus influenzae Rd KW20 lipopolysaccharide biosynthesis protein NP_439841.1 1768610 R 71421 CDS NP_439842.2 30995470 950658 complement(1769521..1770726) 1 NC_000907.1 similar to GB:AE000666; lipopolysaccharide biosynthesis protein 1770726 950658 HI1700 Haemophilus influenzae Rd KW20 lipopolysaccharide biosynthesis protein NP_439842.2 1769521 R 71421 CDS NP_439843.1 16273588 949784 1770861..1771604 1 NC_000907.1 similar to PID:1652989; hypothetical protein 1771604 949784 HI1701 Haemophilus influenzae Rd KW20 hypothetical protein NP_439843.1 1770861 D 71421 CDS NP_439844.1 16273589 949942 complement(1771826..1774096) 1 NC_000907.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 1774096 metE 949942 metE Haemophilus influenzae Rd KW20 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase NP_439844.1 1771826 R 71421 CDS NP_439845.1 16273590 950522 complement(1774289..1775365) 1 NC_000907.1 similar to GB:U14003 SP:P39341 PID:537104 GB:U00096 PID:1790713; hypothetical protein 1775365 950522 HI1703 Haemophilus influenzae Rd KW20 hypothetical protein NP_439845.1 1774289 R 71421 CDS NP_439846.1 16273591 949709 complement(1775349..1776467) 1 NC_000907.1 similar to GB:U14003 SP:P39340 PID:537103 GB:U00096 PID:1790712; hypothetical protein 1776467 949709 HI1704 Haemophilus influenzae Rd KW20 hypothetical protein NP_439846.1 1775349 R 71421 CDS NP_439847.1 16273592 949712 1776575..1778050 1 NC_000907.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 1778050 pepA 949712 pepA Haemophilus influenzae Rd KW20 leucyl aminopeptidase NP_439847.1 1776575 D 71421 CDS NP_439848.2 30995471 950523 complement(1778086..1780029) 1 NC_000907.1 similar to SP:P17447 GB:X52905 PID:48716 GB:U00096 PID:1657512; high affinity choline transport protein 1780029 betT 950523 betT Haemophilus influenzae Rd KW20 high affinity choline transport protein NP_439848.2 1778086 R 71421 CDS NP_439849.1 16273594 950868 complement(1780390..1781745) 1 NC_000907.1 similar to SP:P40719 PID:882556 GB:U00096 PID:1789403; sensor protein QseC 1781745 ygiY 950868 ygiY Haemophilus influenzae Rd KW20 sensor protein QseC NP_439849.1 1780390 R 71421 CDS NP_439850.1 16273595 950525 complement(1781742..1782407) 1 NC_000907.1 similar to PID:882555 SP:P52076 GB:U00096 PID:1789402; transcriptional regulatory protein 1782407 ygiX 950525 ygiX Haemophilus influenzae Rd KW20 transcriptional regulatory protein NP_439850.1 1781742 R 71421 CDS NP_439851.1 16273596 950526 complement(1782470..1782835) 1 NC_000907.1 similar to PID:882554 SP:P52083 GB:U00096 PID:1789401; hypothetical protein 1782835 950526 HI1709 Haemophilus influenzae Rd KW20 hypothetical protein NP_439851.1 1782470 R 71421 CDS NP_439853.1 16273598 950531 complement(1783345..1783845) 1 NC_000907.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter subunit 1783845 crr 950531 crr Haemophilus influenzae Rd KW20 PTS system glucose-specific transporter subunit NP_439853.1 1783345 R 71421 CDS NP_439854.1 16273599 950872 complement(1783905..1785632) 1 NC_000907.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 1785632 ptsI 950872 ptsI Haemophilus influenzae Rd KW20 phosphoenolpyruvate-protein phosphotransferase NP_439854.1 1783905 R 71421 CDS NP_439855.1 16273600 950527 complement(1785712..1785969) 1 NC_000907.1 similar to SP:P07006 PID:153936 PID:47845; phosphocarrier protein HPr 1785969 ptsH 950527 ptsH Haemophilus influenzae Rd KW20 phosphocarrier protein HPr NP_439855.1 1785712 R 71421 CDS NP_439856.1 16273601 950871 complement(1786128..1787168) 1 NC_000907.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 1787168 950871 HI1714 Haemophilus influenzae Rd KW20 ribosome-associated GTPase NP_439856.1 1786128 R 71421 CDS NP_439857.1 16273602 950529 1787239..1787787 1 NC_000907.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 1787787 950529 HI1715 Haemophilus influenzae Rd KW20 oligoribonuclease NP_439857.1 1787239 D 71421 CDS NP_439858.1 16273603 950539 complement(1788088..1789155) 1 NC_000907.1 rfe; similar to GB:M87049 SP:P24235 GB:M76129 PID:147578 PID:148187; undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase 1789155 950539 HI1716 Haemophilus influenzae Rd KW20 undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase NP_439858.1 1788088 R 71421 CDS NP_439860.1 16273605 950533 complement(1790426..1793017) 1 NC_000907.1 similar to GB:M96431 SP:P27249 PID:146155 PID:49393 PID:473822; PII uridylyl-transferase 1793017 glnD 950533 glnD Haemophilus influenzae Rd KW20 PII uridylyl-transferase NP_439860.1 1790426 R 71421 CDS NP_439861.2 30995472 950873 1793136..1793645 1 NC_000907.1 similar to GB:U09558 PID:495495; hypothetical protein 1793645 950873 HI1720 Haemophilus influenzae Rd KW20 hypothetical protein NP_439861.2 1793136 D 71421 CDS NP_439862.2 30995473 950534 1793696..1794463 1 NC_000907.1 similar to SP:P19769 GB:X07037 PID:581111 PID:912474 GB:U00096; transposase 1794463 950534 HI1721 Haemophilus influenzae Rd KW20 transposase NP_439862.2 1793696 D 71421 CDS NP_439863.1 16273608 950876 complement(1794526..1795332) 1 NC_000907.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 1795332 map 950876 map Haemophilus influenzae Rd KW20 methionine aminopeptidase NP_439863.1 1794526 R 71421 CDS NP_439864.1 16273609 950536 1795468..1795812 1 NC_000907.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 1795812 950536 HI1723 Haemophilus influenzae Rd KW20 iron-sulfur cluster insertion protein ErpA NP_439864.1 1795468 D 71421 CDS NP_439865.2 30995474 950875 1795814..1796167 1 NC_000907.1 similar to SP:P45567 GB:U00096 PID:1786310; hypothetical protein 1796167 950875 HI1724 Haemophilus influenzae Rd KW20 hypothetical protein NP_439865.2 1795814 D 71421 CDS NP_439866.1 16273611 950545 1796174..1798519 1 NC_000907.1 similar to GB:D26562 SP:P02919 GB:M12486 GB:X02163 PID:145948; penicillin-binding protein 1B 1798519 ponB 950545 ponB Haemophilus influenzae Rd KW20 penicillin-binding protein 1B NP_439866.1 1796174 D 71421 CDS NP_439867.2 30995475 950883 1798692..1799564 1 NC_000907.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 1799564 hemH 950883 hemH Haemophilus influenzae Rd KW20 phosphoribosylaminoimidazole-succinocarboxamide synthase NP_439867.2 1798692 D 71421 CDS NP_439868.1 16273613 950537 1799720..1801054 1 NC_000907.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 1801054 argG 950537 argG Haemophilus influenzae Rd KW20 argininosuccinate synthase NP_439868.1 1799720 D 71421 CDS NP_439869.1 16273614 950517 complement(1801125..1802318) 1 NC_000907.1 similar to SP:P42964 PID:707085 PID:1805475 GB:AL009126; hypothetical protein 1802318 950517 HI1728 Haemophilus influenzae Rd KW20 hypothetical protein NP_439869.1 1801125 R 71421 CDS NP_439870.1 16273656 950524 complement(1802362..1803099) 1 NC_000907.1 LamB/YcsF family protein 1803099 950524 HI1729m Haemophilus influenzae Rd KW20 LamB/YcsF family protein NP_439870.1 1802362 R 71421 CDS NP_439871.1 16273615 950540 complement(1803086..1804015) 1 NC_000907.1 similar to GB:U00096 SP:P75745 PID:1786930; hypothetical protein 1804015 950540 HI1730 Haemophilus influenzae Rd KW20 hypothetical protein NP_439871.1 1803086 R 71421 CDS NP_439872.1 16273616 950880 complement(1804012..1804653) 1 NC_000907.1 similar to GB:U00096 SP:P75744 PID:1786929; hypothetical protein 1804653 950880 HI1731 Haemophilus influenzae Rd KW20 hypothetical protein NP_439872.1 1804012 R 71421 CDS NP_439873.1 16273668 950541 complement(1804886..1807948) 1 NC_000907.1 Hsf-like protein 1807948 950541 HI1731a Haemophilus influenzae Rd KW20 Hsf-like protein NP_439873.1 1804886 R 71421 CDS NP_439875.1 16273617 950879 complement(1809215..1811194) 1 NC_000907.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II 1811194 rnb 950879 rnb Haemophilus influenzae Rd KW20 exoribonuclease II NP_439875.1 1809215 R 71421 CDS NP_439876.2 30995476 950535 complement(1811277..1812065) 1 NC_000907.1 acyl-carrier-protein reductase; similar to GB:M97219 SP:P29132 GB:X78733 PID:145851 PID:587106; enoyl reductase 1812065 fabI 950535 fabI Haemophilus influenzae Rd KW20 enoyl reductase NP_439876.2 1811277 R 71421 CDS NP_439877.1 16273619 950874 1812244..1813827 1 NC_000907.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 1813827 prfC 950874 prfC Haemophilus influenzae Rd KW20 peptide chain release factor 3 NP_439877.1 1812244 D 71421 CDS NP_439878.1 16273620 950544 complement(1813903..1814136) 1 NC_000907.1 hypothetical protein 1814136 950544 HI1736 Haemophilus influenzae Rd KW20 hypothetical protein NP_439878.1 1813903 R 71421 CDS NP_439879.1 16273621 950881 complement(1814239..1814568) 1 NC_000907.1 similar to GB:AL009126; branched-chain amino acid ABC transporter permease 1814568 950881 HI1737 Haemophilus influenzae Rd KW20 branched-chain amino acid ABC transporter permease NP_439879.1 1814239 R 71421 CDS NP_439880.1 16273622 950553 complement(1814565..1815299) 1 NC_000907.1 similar to GB:AL009126; branched-chain amino acid ABC transporter permease 1815299 950553 HI1738 Haemophilus influenzae Rd KW20 branched-chain amino acid ABC transporter permease NP_439880.1 1814565 R 71421 CDS NP_439881.1 16273623 950886 complement(1815309..1816238) 1 NC_000907.1 similar to GB:J04155 SP:P19797 GB:M37630 PID:1790262; transcriptional activator 1816238 metR 950886 metR Haemophilus influenzae Rd KW20 transcriptional activator NP_439881.1 1815309 R 71421 CDS NP_439882.1 16273624 950543 complement(1822366..1823511) 1 NC_000907.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 1823511 lldD 950543 lldD Haemophilus influenzae Rd KW20 L-lactate dehydrogenase NP_439882.1 1822366 R 71421 CDS NP_439883.1 16273625 950882 complement(1823723..1824532) 1 NC_000907.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1824532 murI 950882 murI Haemophilus influenzae Rd KW20 glutamate racemase NP_439883.1 1823723 R 71421 CDS NP_439884.1 16273626 950549 complement(1824562..1826643) 1 NC_000907.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 1826643 recG 950549 recG Haemophilus influenzae Rd KW20 ATP-dependent DNA helicase RecG NP_439884.1 1824562 R 71421 CDS NP_439885.2 30995477 950884 complement(1826640..1828754) 1 NC_000907.1 similar to GB:L10328 SP:P17580 GB:M24503 PID:290500 PID:551840; guanosine-3'5'-bis(diphosphate) 3'- pyrophosphohydrolase 1828754 spoT 950884 spoT Haemophilus influenzae Rd KW20 guanosine-3'5'-bis(diphosphate) 3'- pyrophosphohydrolase NP_439885.2 1826640 R 71421 CDS NP_439886.1 16273628 950552 complement(1828934..1829200) 1 NC_000907.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 1829200 rpoZ 950552 rpoZ Haemophilus influenzae Rd KW20 DNA-directed RNA polymerase subunit omega NP_439886.1 1828934 R 71421 CDS NP_439887.1 16273629 950885 complement(1829263..1829889) 1 NC_000907.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1829889 gmk 950885 gmk Haemophilus influenzae Rd KW20 guanylate kinase NP_439887.1 1829263 R 71421 CDS