-- dump date 20140619_104412 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 374931000001 SEQ_END SEQ_END NC_009567.1 1887192 1887192 DR NC_009567.1; contig end 1887192..1887192 Haemophilus influenzae PittGG YP_001291510.1 CDS CGSHiGG_10220 NC_009567.1 1886944 333 D COG3102 Uncharacterized protein conserved in bacteria; hypothetical protein join(1886944..1887192,1..333) Haemophilus influenzae PittGG 5227848 YP_001291511.1 CDS CGSHiGG_00010 NC_009567.1 370 621 D COG3102 Uncharacterized protein conserved in bacteria; lipoprotein 370..621 Haemophilus influenzae PittGG 5227847 YP_001291512.1 CDS CGSHiGG_00015 NC_009567.1 647 1111 D COG3133 Outer membrane lipoprotein; 15 kDa peptidoglycan-associated lipoprotein 647..1111 Haemophilus influenzae PittGG 5227928 YP_001291513.1 CDS CGSHiGG_00020 NC_009567.1 1569 2264 R hypothetical protein complement(1569..2264) Haemophilus influenzae PittGG 5227929 YP_001291514.1 CDS CGSHiGG_00025 NC_009567.1 2360 2581 R hypothetical protein complement(2360..2581) Haemophilus influenzae PittGG 5227930 YP_001291515.1 CDS CGSHiGG_00030 NC_009567.1 2583 2681 R COG0463 Glycosyltransferases involved in cell wall biogenesis; hypothetical protein complement(2583..2681) Haemophilus influenzae PittGG 5227931 YP_001291516.1 CDS pgi NC_009567.1 2916 4565 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(2916..4565) Haemophilus influenzae PittGG 5227932 YP_001291517.1 CDS alr NC_009567.1 4662 5744 R converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase complement(4662..5744) Haemophilus influenzae PittGG 5227933 YP_001291518.1 CDS CGSHiGG_00060 NC_009567.1 7302 8738 R catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase complement(7302..8738) Haemophilus influenzae PittGG 5227934 YP_001291519.1 CDS CGSHiGG_00065 NC_009567.1 9247 9567 D putative integrase 9247..9567 Haemophilus influenzae PittGG 5227936 YP_001291520.1 CDS CGSHiGG_00070 NC_009567.1 9557 9928 R COG0582 Integrase; hypothetical protein complement(9557..9928) Haemophilus influenzae PittGG 5227937 YP_001291521.1 CDS CGSHiGG_00075 NC_009567.1 10056 10226 D integrase 10056..10226 Haemophilus influenzae PittGG 5227938 YP_001291522.1 CDS CGSHiGG_00080 NC_009567.1 10165 10689 R COG0582 Integrase; hypothetical protein complement(10165..10689) Haemophilus influenzae PittGG 5227939 YP_001291523.1 CDS CGSHiGG_00085 NC_009567.1 10689 10922 D hypothetical protein 10689..10922 Haemophilus influenzae PittGG 5227940 YP_001291524.1 CDS CGSHiGG_00090 NC_009567.1 10934 11635 D COG4383 Mu-like prophage protein gp29; hypothetical protein 10934..11635 Haemophilus influenzae PittGG 5227941 YP_001291525.1 CDS CGSHiGG_00095 NC_009567.1 11771 12187 D COG5005 Mu-like prophage protein gpG; hypothetical protein 11771..12187 Haemophilus influenzae PittGG 5227942 YP_001291526.1 CDS CGSHiGG_00100 NC_009567.1 12561 13358 R COG3475 LPS biosynthesis protein; lic-1 operon protein complement(12561..13358) Haemophilus influenzae PittGG 5227943 YP_001291527.1 CDS CGSHiGG_00105 NC_009567.1 13358 14059 R COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes; lic-1 operon protein complement(13358..14059) Haemophilus influenzae PittGG 5227944 YP_001291528.1 CDS CGSHiGG_00110 NC_009567.1 14056 14934 R COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; lic-1 operon protein complement(14056..14934) Haemophilus influenzae PittGG 5227945 YP_001291529.1 CDS CGSHiGG_00115 NC_009567.1 14934 15914 R hypothetical protein complement(14934..15914) Haemophilus influenzae PittGG 5227946 YP_001291530.1 CDS CGSHiGG_00120 NC_009567.1 16231 16359 D COG4416 Mu-like prophage protein Com; hypothetical protein 16231..16359 Haemophilus influenzae PittGG 5227947 YP_001291531.1 CDS CGSHiGG_00125 NC_009567.1 16426 16962 D COG3101 Uncharacterized protein conserved in bacteria; hypothetical protein 16426..16962 Haemophilus influenzae PittGG 5227948 YP_001291532.1 CDS CGSHiGG_00130 NC_009567.1 17164 18360 D Sel1 domain-containing protein 17164..18360 Haemophilus influenzae PittGG 5227949 YP_001291533.1 CDS CGSHiGG_00135 NC_009567.1 18363 19262 D COG0790 FOG: TPR repeat, SEL1 subfamily; hypothetical protein 18363..19262 Haemophilus influenzae PittGG 5227950 YP_001291534.1 CDS CGSHiGG_00140 NC_009567.1 19275 20039 D COG0790 FOG: TPR repeat, SEL1 subfamily; Sel1 repeat-containing protein 19275..20039 Haemophilus influenzae PittGG 5227951 YP_001291535.1 CDS CGSHiGG_00145 NC_009567.1 20039 21061 D COG0790 FOG: TPR repeat, SEL1 subfamily; pyruvate kinase 20039..21061 Haemophilus influenzae PittGG 5227952 YP_001291536.1 CDS prfA NC_009567.1 21168 22253 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 21168..22253 Haemophilus influenzae PittGG 5227953 YP_001291537.1 CDS CGSHiGG_00155 NC_009567.1 22306 22746 D COG1714 Predicted membrane protein/domain; hypothetical protein 22306..22746 Haemophilus influenzae PittGG 5227954 YP_001291538.1 CDS CGSHiGG_00160 NC_009567.1 22746 23624 D COG2890 Methylase of polypeptide chain release factors; hypothetical protein 22746..23624 Haemophilus influenzae PittGG 5227955 YP_001291539.1 CDS prfA NC_009567.1 23624 24427 D COG2912 Uncharacterized conserved protein; hypothetical protein 23624..24427 Haemophilus influenzae PittGG 5227956 YP_001291540.1 CDS CGSHiGG_00170 NC_009567.1 24442 25296 D catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 24442..25296 Haemophilus influenzae PittGG 5227957 YP_001291541.1 CDS CGSHiGG_00175 NC_009567.1 25356 26303 D Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor; glycerate dehydrogenase 25356..26303 Haemophilus influenzae PittGG 5227958 YP_001291542.1 CDS CGSHiGG_00180 NC_009567.1 26303 27379 D COG4591 ABC-type transport system, involved in lipoprotein release, permease component; glycerate dehydrogenase 26303..27379 Haemophilus influenzae PittGG 5227959 YP_001291543.1 CDS CGSHiGG_00185 NC_009567.1 27498 28787 D catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine--8-amino-7-oxononanoate transaminase 27498..28787 Haemophilus influenzae PittGG 5227960 YP_001291544.1 CDS CGSHiGG_00190 NC_009567.1 28796 29935 D catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 28796..29935 Haemophilus influenzae PittGG 5227961 YP_001291545.1 CDS CGSHiGG_00195 NC_009567.1 29945 30592 D COG2830 Uncharacterized protein conserved in bacteria; hypothetical protein 29945..30592 Haemophilus influenzae PittGG 5227962 YP_001291546.1 CDS CGSHiGG_00200 NC_009567.1 30580 31362 D COG0500 SAM-dependent methyltransferases; 8-amino-7-oxononanoate synthase 30580..31362 Haemophilus influenzae PittGG 5227963 YP_001291547.1 CDS bioD NC_009567.1 31372 32013 D DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 31372..32013 Haemophilus influenzae PittGG 5227964 YP_001291548.1 CDS bioD NC_009567.1 32095 32778 D COG1136 ABC-type antimicrobial peptide transport system, ATPase component; dithiobiotin synthetase 32095..32778 Haemophilus influenzae PittGG 5227965 YP_001291549.1 CDS CGSHiGG_00215 NC_009567.1 32778 34028 D part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 32778..34028 Haemophilus influenzae PittGG 5227849 YP_001291550.1 CDS CGSHiGG_00220 NC_009567.1 34246 35334 D catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 34246..35334 Haemophilus influenzae PittGG 5227850 YP_001291551.1 CDS CGSHiGG_00225 NC_009567.1 35404 35844 R hypothetical protein complement(35404..35844) Haemophilus influenzae PittGG 5227851 YP_001291552.1 CDS CGSHiGG_00230 NC_009567.1 36127 37371 D involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 36127..37371 Haemophilus influenzae PittGG 5227852 YP_001291553.1 CDS CGSHiGG_00235 NC_009567.1 37492 38106 D COG2249 Putative NADPH-quinone reductase (modulator of drug activity B); putative NAD(P)H oxidoreductase 37492..38106 Haemophilus influenzae PittGG 5227853 YP_001291554.1 CDS CGSHiGG_00240 NC_009567.1 38099 38653 D COG3381 Uncharacterized component of anaerobic dehydrogenases; putative component of anaerobic dehydrogenase 38099..38653 Haemophilus influenzae PittGG 5227854 YP_001291555.1 CDS CGSHiGG_00245 NC_009567.1 38700 39209 R COG0778 Nitroreductase; nitroreductase complement(38700..39209) Haemophilus influenzae PittGG 5227855 YP_001291556.1 CDS CGSHiGG_00265 NC_009567.1 41240 42037 R COG3475 LPS biosynthesis protein; lic-1 operon protein complement(41240..42037) Haemophilus influenzae PittGG 5227856 YP_001291557.1 CDS CGSHiGG_00270 NC_009567.1 42037 42738 R COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes; lic-1 operon protein complement(42037..42738) Haemophilus influenzae PittGG 5227857 YP_001291558.1 CDS CGSHiGG_00275 NC_009567.1 42735 43613 R COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; lic-1 operon protein complement(42735..43613) Haemophilus influenzae PittGG 5227858 YP_001291559.1 CDS CGSHiGG_00280 NC_009567.1 43613 44716 R COG0510 Predicted choline kinase involved in LPS biosynthesis; phospho-2-dehydro-3-heoxyheptonate aldolase complement(43613..44716) Haemophilus influenzae PittGG 5227859 YP_001291560.1 CDS mnmC NC_009567.1 44804 46816 R catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase complement(44804..46816) Haemophilus influenzae PittGG 5227860 YP_001291561.1 CDS CGSHiGG_00290 NC_009567.1 46965 48185 D FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase I 46965..48185 Haemophilus influenzae PittGG 5227861 YP_001291562.1 CDS grxA NC_009567.1 48252 48515 R functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 1 complement(48252..48515) Haemophilus influenzae PittGG 5227862 YP_001291563.1 CDS CGSHiGG_00300 NC_009567.1 48630 49538 D COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); ribosomal protein S6 modification protein 48630..49538 Haemophilus influenzae PittGG 5227863 YP_001291564.1 CDS grxA NC_009567.1 49577 50791 R COG0786 Na+/glutamate symporter; glutaredoxin 1 complement(49577..50791) Haemophilus influenzae PittGG 5227864 YP_001291565.1 CDS CGSHiGG_00310 NC_009567.1 50833 53076 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A complement(50833..53076) Haemophilus influenzae PittGG 5227865 YP_001291566.1 CDS CGSHiGG_00325 NC_009567.1 55113 56048 R Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase complement(55113..56048) Haemophilus influenzae PittGG 5227866 YP_001291567.1 CDS CGSHiGG_00330 NC_009567.1 56145 57575 D catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 56145..57575 Haemophilus influenzae PittGG 5227867 YP_001291568.1 CDS CGSHiGG_00335 NC_009567.1 57940 58035 R putative type I restriction enzyme HindVIIP R protein complement(57940..58035) Haemophilus influenzae PittGG 5227868 YP_001291569.1 CDS CGSHiGG_00340 NC_009567.1 58384 58608 R COG2870 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase complement(58384..58608) Haemophilus influenzae PittGG 5227869 YP_001291570.1 CDS CGSHiGG_00345 NC_009567.1 58603 58920 D COG0488 ATPase components of ABC transporters with duplicated ATPase domains; ABC transporter ATP-binding protein 58603..58920 Haemophilus influenzae PittGG 5227870 YP_001291571.1 CDS CGSHiGG_00360 NC_009567.1 59766 60905 R COG0687 Spermidine/putrescine-binding periplasmic protein; ABC transporter ATPase complement(59766..60905) Haemophilus influenzae PittGG 5227871 YP_001291572.1 CDS potC NC_009567.1 60978 61748 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein complement(60978..61748) Haemophilus influenzae PittGG 5227872 YP_001291573.1 CDS potA NC_009567.1 62591 63709 R functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase protein complement(62591..63709) Haemophilus influenzae PittGG 5227873 YP_001291574.1 CDS CGSHiGG_00385 NC_009567.1 64004 65242 D catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 64004..65242 Haemophilus influenzae PittGG 5227874 YP_001291575.1 CDS CGSHiGG_00390 NC_009567.1 65719 66201 R COG0783 DNA-binding ferritin-like protein (oxidative damage protectant); peptidase T complement(65719..66201) Haemophilus influenzae PittGG 5227875 YP_001291576.1 CDS CGSHiGG_00395 NC_009567.1 66474 67352 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 66474..67352 Haemophilus influenzae PittGG 5227876 YP_001291577.1 CDS CGSHiGG_00400 NC_009567.1 67395 68360 R COG0500 SAM-dependent methyltransferases; hypothetical protein complement(67395..68360) Haemophilus influenzae PittGG 5227877 YP_001291578.1 CDS CGSHiGG_00405 NC_009567.1 68357 69871 R COG0591 Na+/proline symporter; cytidine deaminase complement(68357..69871) Haemophilus influenzae PittGG 5227878 YP_001291579.1 CDS CGSHiGG_00420 NC_009567.1 72008 73672 D catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 72008..73672 Haemophilus influenzae PittGG 5227879 YP_001291580.1 CDS CGSHiGG_00425 NC_009567.1 73750 74202 D COG2983 Uncharacterized conserved protein; hypothetical protein 73750..74202 Haemophilus influenzae PittGG 5227880 YP_001291581.1 CDS CGSHiGG_00440 NC_009567.1 76372 78564 D catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 76372..78564 Haemophilus influenzae PittGG 5227881 YP_001291582.1 CDS CGSHiGG_00445 NC_009567.1 78663 80642 D COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases; glycogen branching enzyme 78663..80642 Haemophilus influenzae PittGG 5227882 YP_001291583.1 CDS glgC NC_009567.1 80665 81966 D catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 80665..81966 Haemophilus influenzae PittGG 5227883 YP_001291584.1 CDS glgA NC_009567.1 82074 83504 D catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 82074..83504 Haemophilus influenzae PittGG 5227884 YP_001291585.1 CDS glgA NC_009567.1 83751 86216 D COG0058 Glucan phosphorylase; glycogen synthase 83751..86216 Haemophilus influenzae PittGG 5227885 YP_001291586.1 CDS pntA NC_009567.1 86477 88015 D forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 86477..88015 Haemophilus influenzae PittGG 5227886 YP_001291587.1 CDS pntB NC_009567.1 88026 89450 D catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 88026..89450 Haemophilus influenzae PittGG 5227887 YP_001291588.1 CDS CGSHiGG_00485 NC_009567.1 90528 93134 D catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 90528..93134 Haemophilus influenzae PittGG 5227888 YP_001291589.1 CDS CGSHiGG_00490 NC_009567.1 93210 93794 R COG1182 Acyl carrier protein phosphodiesterase; DNA topoisomerase I complement(93210..93794) Haemophilus influenzae PittGG 5227889 YP_001291590.1 CDS CGSHiGG_00495 NC_009567.1 94079 96010 D catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 94079..96010 Haemophilus influenzae PittGG 5227890 YP_001291591.1 CDS CGSHiGG_00500 NC_009567.1 96122 98701 R COG0612 Predicted Zn-dependent peptidases; putative zinc protease complement(96122..98701) Haemophilus influenzae PittGG 5227891 YP_001291592.1 CDS CGSHiGG_00505 NC_009567.1 98670 98915 R zinc protease complement(98670..98915) Haemophilus influenzae PittGG 5227892 YP_001291593.1 CDS CGSHiGG_00520 NC_009567.1 101601 101810 R COG3585 Molybdopterin-binding protein; putative molybdenum-pterin binding protein complement(101601..101810) Haemophilus influenzae PittGG 5227893 YP_001291594.1 CDS CGSHiGG_00525 NC_009567.1 101928 102257 R COG2920 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit; putative dissimilatory sulfite reductase, desulfoviridin subunit gamma complement(101928..102257) Haemophilus influenzae PittGG 5227894 YP_001291595.1 CDS CGSHiGG_00540 NC_009567.1 103348 104682 D acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 103348..104682 Haemophilus influenzae PittGG 5227895 YP_001291596.1 CDS CGSHiGG_00545 NC_009567.1 104695 105651 D modification methylase HaeII 104695..105651 Haemophilus influenzae PittGG 5227896 YP_001291597.1 CDS mukB NC_009567.1 107452 111984 D SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 107452..111984 Haemophilus influenzae PittGG 5227897 YP_001291598.1 CDS CGSHiGG_00575 NC_009567.1 112054 112962 D COG3586 Uncharacterized conserved protein; hypothetical protein 112054..112962 Haemophilus influenzae PittGG 5227898 YP_001291599.1 CDS mukB NC_009567.1 113211 113840 D COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; cell division protein MukB 113211..113840 Haemophilus influenzae PittGG 5227899 YP_001291600.1 CDS sbcB NC_009567.1 113853 115274 D Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 113853..115274 Haemophilus influenzae PittGG 5227900 YP_001291601.1 CDS CGSHiGG_00590 NC_009567.1 115682 115969 D hypothetical protein 115682..115969 Haemophilus influenzae PittGG 5227901 YP_001291602.1 CDS CGSHiGG_00595 NC_009567.1 115956 116150 R COG2925 Exonuclease I; hypothetical protein complement(115956..116150) Haemophilus influenzae PittGG 5227902 YP_001291603.1 CDS CGSHiGG_00600 NC_009567.1 116339 116800 R hypothetical protein complement(116339..116800) Haemophilus influenzae PittGG 5227903 YP_001291604.1 CDS CGSHiGG_00605 NC_009567.1 116797 116982 R RstR-like phage repressor protein complement(116797..116982) Haemophilus influenzae PittGG 5227904 YP_001291605.1 CDS CGSHiGG_00610 NC_009567.1 117135 118283 D hypothetical protein 117135..118283 Haemophilus influenzae PittGG 5227905 YP_001291606.1 CDS CGSHiGG_00615 NC_009567.1 118323 118649 D hypothetical protein 118323..118649 Haemophilus influenzae PittGG 5227906 YP_001291607.1 CDS CGSHiGG_00620 NC_009567.1 118649 118738 D hypothetical protein 118649..118738 Haemophilus influenzae PittGG 5227907 YP_001291608.1 CDS CGSHiGG_00625 NC_009567.1 118735 119007 D hypothetical protein 118735..119007 Haemophilus influenzae PittGG 5227908 YP_001291609.1 CDS CGSHiGG_00630 NC_009567.1 119026 119256 D hypothetical protein 119026..119256 Haemophilus influenzae PittGG 5227909 YP_001291610.1 CDS CGSHiGG_00635 NC_009567.1 119307 120707 D hypothetical protein 119307..120707 Haemophilus influenzae PittGG 5227910 YP_001291611.1 CDS CGSHiGG_00640 NC_009567.1 120716 121012 D COG0181 Porphobilinogen deaminase; putative phage-like membrane protein 120716..121012 Haemophilus influenzae PittGG 5227911 YP_001291612.1 CDS CGSHiGG_00645 NC_009567.1 121016 122056 D COG4128 Zonula occludens toxin; putative phage-like membrane protein 121016..122056 Haemophilus influenzae PittGG 5227912 YP_001291613.1 CDS CGSHiGG_00650 NC_009567.1 122053 123186 D COG1450 Type II secretory pathway, component PulD; putative phage-like secreted protein 122053..123186 Haemophilus influenzae PittGG 5227913 YP_001291614.1 CDS CGSHiGG_00655 NC_009567.1 123991 125268 R COG0642 Signal transduction histidine kinase; phosphate regulon sensor protein PhoR complement(123991..125268) Haemophilus influenzae PittGG 5227914 YP_001291615.1 CDS CGSHiGG_00660 NC_009567.1 125265 125960 R COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; phosphate regulon transcriptional regulatory protein PhoB complement(125265..125960) Haemophilus influenzae PittGG 5227915 YP_001291616.1 CDS CGSHiGG_00665 NC_009567.1 126057 126824 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(126057..126824) Haemophilus influenzae PittGG 5227916 YP_001291617.1 CDS CGSHiGG_00670 NC_009567.1 126834 127682 R COG0581 ABC-type phosphate transport system, permease component; phosphate transport system permease protein PstA complement(126834..127682) Haemophilus influenzae PittGG 5227917 YP_001291618.1 CDS CGSHiGG_00675 NC_009567.1 127684 128631 R COG0573 ABC-type phosphate transport system, permease component; phosphate transport system permease protein PstC complement(127684..128631) Haemophilus influenzae PittGG 5227918 YP_001291619.1 CDS CGSHiGG_00680 NC_009567.1 128722 129741 R COG0226 ABC-type phosphate transport system, periplasmic component; phosphate-binding periplasmic protein PstS complement(128722..129741) Haemophilus influenzae PittGG 5227919 YP_001291620.1 CDS CGSHiGG_00685 NC_009567.1 130243 130731 D COG1528 Ferritin-like protein; ferritin like protein 1 130243..130731 Haemophilus influenzae PittGG 5227920 YP_001291621.1 CDS CGSHiGG_00690 NC_009567.1 130747 131244 D COG1528 Ferritin-like protein; ferritin 130747..131244 Haemophilus influenzae PittGG 5227921 YP_001291622.1 CDS sbcB NC_009567.1 131528 133084 D with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 131528..133084 Haemophilus influenzae PittGG 5227922 YP_001291623.1 CDS CGSHiGG_00700 NC_009567.1 133097 133678 D TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 133097..133678 Haemophilus influenzae PittGG 5227923 YP_001291624.1 CDS CGSHiGG_00705 NC_009567.1 133727 134113 D COG0512 Anthranilate/para-aminobenzoate synthases component II; anthranilate synthase component II 133727..134113 Haemophilus influenzae PittGG 5227924 YP_001291625.1 CDS trpD NC_009567.1 134166 135167 D Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 134166..135167 Haemophilus influenzae PittGG 5227925 YP_001291626.1 CDS CGSHiGG_00715 NC_009567.1 135208 136638 D monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 135208..136638 Haemophilus influenzae PittGG 5227926 YP_001291627.1 CDS CGSHiGG_00720 NC_009567.1 136700 136972 D COG0298 Hydrogenase maturation factor; hydrogenase 2 accessory protein HypG 136700..136972 Haemophilus influenzae PittGG 5227927 YP_001291628.1 CDS valS NC_009567.1 137004 139868 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(137004..139868) Haemophilus influenzae PittGG 5227966 YP_001291629.1 CDS CGSHiGG_00730 NC_009567.1 140096 140320 R hypothetical protein complement(140096..140320) Haemophilus influenzae PittGG 5227967 YP_001291630.1 CDS CGSHiGG_00735 NC_009567.1 140364 140447 R hypothetical protein complement(140364..140447) Haemophilus influenzae PittGG 5227968 YP_001291631.1 CDS CGSHiGG_00740 NC_009567.1 140524 141177 R COG0525 Valyl-tRNA synthetase; hypothetical protein complement(140524..141177) Haemophilus influenzae PittGG 5227969 YP_001291632.1 CDS valS NC_009567.1 141178 141483 R COG3097 Uncharacterized protein conserved in bacteria; hypothetical protein complement(141178..141483) Haemophilus influenzae PittGG 5227970 YP_001291633.1 CDS CGSHiGG_00750 NC_009567.1 141487 141921 R binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi complement(141487..141921) Haemophilus influenzae PittGG 5227971 YP_001291634.1 CDS fumC NC_009567.1 142156 143550 D class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 142156..143550 Haemophilus influenzae PittGG 5227972 YP_001291635.1 CDS CGSHiGG_00760 NC_009567.1 143678 144286 D COG0114 Fumarase; hypothetical protein 143678..144286 Haemophilus influenzae PittGG 5227973 YP_001291636.1 CDS fumC NC_009567.1 144385 145209 R COG0613 Predicted metal-dependent phosphoesterases (PHP family); fumarate hydratase complement(144385..145209) Haemophilus influenzae PittGG 5227974 YP_001291637.1 CDS CGSHiGG_00770 NC_009567.1 145209 146228 R catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 complement(145209..146228) Haemophilus influenzae PittGG 5227975 YP_001291638.1 CDS CGSHiGG_00785 NC_009567.1 147366 147821 R COG1855 ATPase (PilT family); hypothetical protein complement(147366..147821) Haemophilus influenzae PittGG 5227976 YP_001291639.1 CDS CGSHiGG_00790 NC_009567.1 147834 148934 R COG3566 Uncharacterized protein conserved in bacteria; hypothetical protein complement(147834..148934) Haemophilus influenzae PittGG 5227977 YP_001291640.1 CDS CGSHiGG_00795 NC_009567.1 149075 150358 R COG2369 Uncharacterized protein, homolog of phage Mu protein gp30; hypothetical protein complement(149075..150358) Haemophilus influenzae PittGG 5227978 YP_001291641.1 CDS CGSHiGG_00810 NC_009567.1 151863 152963 R COG1783 Phage terminase large subunit; phage terminase large subunit complement(151863..152963) Haemophilus influenzae PittGG 5227979 YP_001291642.1 CDS CGSHiGG_00815 NC_009567.1 152950 153465 R COG3728 Phage terminase, small subunit; terminase small subunit complement(152950..153465) Haemophilus influenzae PittGG 5227980 YP_001291643.1 CDS CGSHiGG_00820 NC_009567.1 153510 153788 D hypothetical protein 153510..153788 Haemophilus influenzae PittGG 5227981 YP_001291644.1 CDS CGSHiGG_00825 NC_009567.1 153790 154071 R hypothetical protein complement(153790..154071) Haemophilus influenzae PittGG 5227982 YP_001291645.1 CDS CGSHiGG_00830 NC_009567.1 154157 154306 R COG1396 Predicted transcriptional regulators; hypothetical protein complement(154157..154306) Haemophilus influenzae PittGG 5227983 YP_001291646.1 CDS CGSHiGG_00835 NC_009567.1 154299 154892 R hypothetical protein complement(154299..154892) Haemophilus influenzae PittGG 5227984 YP_001291647.1 CDS CGSHiGG_00840 NC_009567.1 154870 155226 R COG3179 Predicted chitinase; hypothetical protein complement(154870..155226) Haemophilus influenzae PittGG 5227985 YP_001291648.1 CDS CGSHiGG_00845 NC_009567.1 155449 156303 R COG3617 Prophage antirepressor; putative antirepressor protein complement(155449..156303) Haemophilus influenzae PittGG 5227986 YP_001291649.1 CDS CGSHiGG_00850 NC_009567.1 156616 157074 R COG1196 Chromosome segregation ATPases; hypothetical protein complement(156616..157074) Haemophilus influenzae PittGG 5227987 YP_001291650.1 CDS CGSHiGG_00855 NC_009567.1 157184 157723 R hypothetical protein complement(157184..157723) Haemophilus influenzae PittGG 5227988 YP_001291651.1 CDS CGSHiGG_00860 NC_009567.1 157901 158269 R hypothetical protein complement(157901..158269) Haemophilus influenzae PittGG 5227989 YP_001291652.1 CDS CGSHiGG_00865 NC_009567.1 158332 158913 R hypothetical protein complement(158332..158913) Haemophilus influenzae PittGG 5227990 YP_001291653.1 CDS CGSHiGG_00870 NC_009567.1 158960 159526 R hypothetical protein complement(158960..159526) Haemophilus influenzae PittGG 5227991 YP_001291654.1 CDS CGSHiGG_00875 NC_009567.1 159526 159618 R hypothetical protein complement(159526..159618) Haemophilus influenzae PittGG 5227992 YP_001291655.1 CDS CGSHiGG_00880 NC_009567.1 159615 159983 R putative recombination protein NinB complement(159615..159983) Haemophilus influenzae PittGG 5227993 YP_001291656.1 CDS CGSHiGG_00885 NC_009567.1 160070 160294 R hypothetical protein complement(160070..160294) Haemophilus influenzae PittGG 5227994 YP_001291657.1 CDS CGSHiGG_00890 NC_009567.1 160281 160931 R hypothetical protein complement(160281..160931) Haemophilus influenzae PittGG 5227995 YP_001291658.1 CDS CGSHiGG_00895 NC_009567.1 160928 161674 R hypothetical protein complement(160928..161674) Haemophilus influenzae PittGG 5227996 YP_001291659.1 CDS CGSHiGG_00900 NC_009567.1 161671 162339 R hypothetical protein complement(161671..162339) Haemophilus influenzae PittGG 5227997 YP_001291660.1 CDS CGSHiGG_00905 NC_009567.1 162386 162733 R hypothetical protein complement(162386..162733) Haemophilus influenzae PittGG 5227998 YP_001291661.1 CDS CGSHiGG_00910 NC_009567.1 162751 162825 R COG3646 Uncharacterized phage-encoded protein; hypothetical protein complement(162751..162825) Haemophilus influenzae PittGG 5227999 YP_001291662.1 CDS CGSHiGG_00915 NC_009567.1 162874 163062 R COG4197 Uncharacterized protein conserved in bacteria, prophage-related; hypothetical protein complement(162874..163062) Haemophilus influenzae PittGG 5228000 YP_001291663.1 CDS CGSHiGG_00920 NC_009567.1 163231 163872 D transcriptional regulator 163231..163872 Haemophilus influenzae PittGG 5228001 YP_001291664.1 CDS CGSHiGG_00925 NC_009567.1 163927 165009 D hypothetical protein 163927..165009 Haemophilus influenzae PittGG 5228002 YP_001291665.1 CDS CGSHiGG_00930 NC_009567.1 164936 165592 R COG2932 Predicted transcriptional regulator; hypothetical protein complement(164936..165592) Haemophilus influenzae PittGG 5228003 YP_001291666.1 CDS CGSHiGG_00935 NC_009567.1 166026 166196 R hypothetical protein complement(166026..166196) Haemophilus influenzae PittGG 5228004 YP_001291667.1 CDS CGSHiGG_00940 NC_009567.1 166211 166432 D hypothetical protein 166211..166432 Haemophilus influenzae PittGG 5228005 YP_001291668.1 CDS CGSHiGG_00945 NC_009567.1 166600 166920 D hypothetical protein 166600..166920 Haemophilus influenzae PittGG 5228006 YP_001291669.1 CDS CGSHiGG_00950 NC_009567.1 166898 167101 R hypothetical protein complement(166898..167101) Haemophilus influenzae PittGG 5228007 YP_001291670.1 CDS CGSHiGG_00955 NC_009567.1 167702 167947 D COG3422 Uncharacterized conserved protein; hypothetical protein 167702..167947 Haemophilus influenzae PittGG 5228008 YP_001291671.1 CDS CGSHiGG_00960 NC_009567.1 168003 168974 D COG0419 ATPase involved in DNA repair; hypothetical protein 168003..168974 Haemophilus influenzae PittGG 5228009 YP_001291672.1 CDS CGSHiGG_00965 NC_009567.1 169312 169563 D phage anti-repressor protein 169312..169563 Haemophilus influenzae PittGG 5228010 YP_001291673.1 CDS CGSHiGG_00970 NC_009567.1 169708 169827 D hypothetical protein 169708..169827 Haemophilus influenzae PittGG 5228011 YP_001291674.1 CDS CGSHiGG_00975 NC_009567.1 169869 170156 D COG3561 Phage anti-repressor protein; hypothetical protein 169869..170156 Haemophilus influenzae PittGG 5228012 YP_001291675.1 CDS CGSHiGG_00980 NC_009567.1 170153 170812 R COG0582 Integrase; integrase/recombinase complement(170153..170812) Haemophilus influenzae PittGG 5228013 YP_001291676.1 CDS CGSHiGG_00985 NC_009567.1 170831 171049 R dihydroorotate dehydrogenase 2 complement(170831..171049) Haemophilus influenzae PittGG 5228014 YP_001291677.1 CDS CGSHiGG_00990 NC_009567.1 171418 171483 R COG0582 Integrase; hypothetical protein complement(171418..171483) Haemophilus influenzae PittGG 5228015 YP_001291678.1 CDS CGSHiGG_00995 NC_009567.1 171575 172348 D Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 171575..172348 Haemophilus influenzae PittGG 5228016 YP_001291679.1 CDS CGSHiGG_01000 NC_009567.1 172377 173399 D with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 172377..173399 Haemophilus influenzae PittGG 5228017 YP_001291680.1 CDS CGSHiGG_01005 NC_009567.1 173596 174432 D COG5266 ABC-type Co2+ transport system, periplasmic component; universal stress protein UspE 173596..174432 Haemophilus influenzae PittGG 5228018 YP_001291681.1 CDS purN NC_009567.1 174516 175154 R glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase complement(174516..175154) Haemophilus influenzae PittGG 5228019 YP_001291682.1 CDS CGSHiGG_01015 NC_009567.1 175209 176243 R catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase complement(175209..176243) Haemophilus influenzae PittGG 5228020 YP_001291683.1 CDS CGSHiGG_01020 NC_009567.1 176472 177182 D COG4221 Short-chain alcohol dehydrogenase of unknown specificity; phosphoribosylaminoimidazole synthetase 176472..177182 Haemophilus influenzae PittGG 5228021 YP_001291684.1 CDS CGSHiGG_01025 NC_009567.1 177199 178395 D catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 177199..178395 Haemophilus influenzae PittGG 5228022 YP_001291685.1 CDS trpA NC_009567.1 178395 179201 D catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 178395..179201 Haemophilus influenzae PittGG 5228023 YP_001291686.1 CDS CGSHiGG_01035 NC_009567.1 179341 180294 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(179341..180294) Haemophilus influenzae PittGG 5228024 YP_001291687.1 CDS CGSHiGG_01040 NC_009567.1 180353 180829 D COG2606 Uncharacterized conserved protein; hypothetical protein 180353..180829 Haemophilus influenzae PittGG 5228025 YP_001291688.1 CDS CGSHiGG_01045 NC_009567.1 180984 181202 R COG1278 Cold shock proteins; aspartate-semialdehyde dehydrogenase complement(180984..181202) Haemophilus influenzae PittGG 5228026 YP_001291689.1 CDS CGSHiGG_01050 NC_009567.1 181351 181509 R COG3140 Uncharacterized protein conserved in bacteria; hypothetical protein complement(181351..181509) Haemophilus influenzae PittGG 5228027 YP_001291690.1 CDS CGSHiGG_01055 NC_009567.1 181502 182221 R catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C complement(181502..182221) Haemophilus influenzae PittGG 5228028 YP_001291691.1 CDS CGSHiGG_01060 NC_009567.1 182215 182535 R COG3098 Uncharacterized protein conserved in bacteria; hypothetical protein complement(182215..182535) Haemophilus influenzae PittGG 5228029 YP_001291692.1 CDS CGSHiGG_01065 NC_009567.1 182550 184007 R Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI complement(182550..184007) Haemophilus influenzae PittGG 5228030 YP_001291693.1 CDS CGSHiGG_01070 NC_009567.1 184166 184405 D catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 184166..184405 Haemophilus influenzae PittGG 5228031 YP_001291694.1 CDS CGSHiGG_01075 NC_009567.1 184405 185295 D COG0142 Geranylgeranyl pyrophosphate synthase; exodeoxyribonuclease VII small subunit 184405..185295 Haemophilus influenzae PittGG 5228032 YP_001291695.1 CDS CGSHiGG_01080 NC_009567.1 185337 187214 D catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 185337..187214 Haemophilus influenzae PittGG 5228033 YP_001291696.1 CDS CGSHiGG_01085 NC_009567.1 187250 187702 R COG2969 Stringent starvation protein B; ClpXP protease specificity-enhancing factor complement(187250..187702) Haemophilus influenzae PittGG 5228034 YP_001291697.1 CDS CGSHiGG_01090 NC_009567.1 187702 188340 R COG0625 Glutathione S-transferase; ClpXP protease specificity-enhancing factor complement(187702..188340) Haemophilus influenzae PittGG 5228035 YP_001291698.1 CDS rpsI NC_009567.1 188521 188913 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(188521..188913) Haemophilus influenzae PittGG 5228036 YP_001291699.1 CDS rplM NC_009567.1 188930 189358 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(188930..189358) Haemophilus influenzae PittGG 5228037 YP_001291700.1 CDS metF NC_009567.1 189822 190700 D MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 189822..190700 Haemophilus influenzae PittGG 5228038 YP_001291701.1 CDS bioD NC_009567.1 190790 191518 R DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase complement(190790..191518) Haemophilus influenzae PittGG 5228039 YP_001291702.1 CDS bioD NC_009567.1 191621 191887 R COG3100 Uncharacterized protein conserved in bacteria; dithiobiotin synthetase complement(191621..191887) Haemophilus influenzae PittGG 5228040 YP_001291703.1 CDS folE NC_009567.1 191948 192604 R involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I complement(191948..192604) Haemophilus influenzae PittGG 5228041 YP_001291704.1 CDS folE NC_009567.1 192742 193956 D COG0303 Molybdopterin biosynthesis enzyme; GTP cyclohydrolase I 192742..193956 Haemophilus influenzae PittGG 5228042 YP_001291705.1 CDS CGSHiGG_01130 NC_009567.1 193960 194691 D ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 193960..194691 Haemophilus influenzae PittGG 5228043 YP_001291706.1 CDS CGSHiGG_01135 NC_009567.1 194758 195081 D highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 194758..195081 Haemophilus influenzae PittGG 5228044 YP_001291707.1 CDS CGSHiGG_01140 NC_009567.1 195138 195665 R COG0526 Thiol-disulfide isomerase and thioredoxins; phosphoribosylformylglycinamidine synthase complement(195138..195665) Haemophilus influenzae PittGG 5228045 YP_001291708.1 CDS CGSHiGG_01145 NC_009567.1 195708 196349 R COG0785 Cytochrome c biogenesis protein; hypothetical protein complement(195708..196349) Haemophilus influenzae PittGG 5228046 YP_001291709.1 CDS CGSHiGG_01150 NC_009567.1 196361 197422 R COG0225 Peptide methionine sulfoxide reductase; bifunctional methionine sulfoxide reductase A/B protein complement(196361..197422) Haemophilus influenzae PittGG 5228047 YP_001291710.1 CDS CGSHiGG_01155 NC_009567.1 197596 198459 D hypothetical protein 197596..198459 Haemophilus influenzae PittGG 5228048 YP_001291711.1 CDS CGSHiGG_01160 NC_009567.1 198554 198727 R COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; dsDNA-mimic protein complement(198554..198727) Haemophilus influenzae PittGG 5228049 YP_001291712.1 CDS CGSHiGG_01165 NC_009567.1 198736 199281 R Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor complement(198736..199281) Haemophilus influenzae PittGG 5228050 YP_001291713.1 CDS CGSHiGG_01170 NC_009567.1 199408 199557 R hypothetical protein complement(199408..199557) Haemophilus influenzae PittGG 5228051 YP_001291714.1 CDS CGSHiGG_01175 NC_009567.1 199641 199793 R hypothetical protein complement(199641..199793) Haemophilus influenzae PittGG 5228052 YP_001291715.1 CDS CGSHiGG_01180 NC_009567.1 199816 199923 R COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; hypothetical protein complement(199816..199923) Haemophilus influenzae PittGG 5228053 YP_001291716.1 CDS CGSHiGG_01185 NC_009567.1 200150 201514 D COG1538 Outer membrane protein; hypothetical protein 200150..201514 Haemophilus influenzae PittGG 5226806 YP_001291717.1 CDS CGSHiGG_01200 NC_009567.1 202334 202828 R COG2062 Phosphohistidine phosphatase SixA; hypothetical protein complement(202334..202828) Haemophilus influenzae PittGG 5226807 YP_001291718.1 CDS CGSHiGG_01215 NC_009567.1 204260 205087 R COG0294 Dihydropteroate synthase and related enzymes; dihydropteroate synthase complement(204260..205087) Haemophilus influenzae PittGG 5226808 YP_001291719.1 CDS CGSHiGG_01220 NC_009567.1 205199 207106 R COG0465 ATP-dependent Zn proteases; RNA polymerase sigma factor complement(205199..207106) Haemophilus influenzae PittGG 5226809 YP_001291720.1 CDS CGSHiGG_01225 NC_009567.1 207197 207784 R COG0293 23S rRNA methylase; cell division protein complement(207197..207784) Haemophilus influenzae PittGG 5226810 YP_001291721.1 CDS rrmJ NC_009567.1 207954 208253 D COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein; 23S rRNA methyltransferase J 207954..208253 Haemophilus influenzae PittGG 5226811 YP_001291722.1 CDS greA NC_009567.1 208292 208768 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(208292..208768) Haemophilus influenzae PittGG 5226812 YP_001291723.1 CDS rpsO NC_009567.1 210687 210956 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(210687..210956) Haemophilus influenzae PittGG 5226813 YP_001291724.1 CDS CGSHiGG_01255 NC_009567.1 211092 211223 R hypothetical protein complement(211092..211223) Haemophilus influenzae PittGG 5226814 YP_001291725.1 CDS rpsO NC_009567.1 211223 211948 R COG0184 Ribosomal protein S15P/S13E; 30S ribosomal protein S15 complement(211223..211948) Haemophilus influenzae PittGG 5226815 YP_001291726.1 CDS CGSHiGG_01265 NC_009567.1 212185 212718 R catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-(acyl carrier protein) dehydratase complement(212185..212718) Haemophilus influenzae PittGG 5226816 YP_001291727.1 CDS CGSHiGG_01270 NC_009567.1 212889 214664 R COG1067 Predicted ATP-dependent protease; 3-hydroxydecanoyl-ACP dehydratase complement(212889..214664) Haemophilus influenzae PittGG 5226817 YP_001291728.1 CDS CGSHiGG_01275 NC_009567.1 214791 215237 D COG3120 Uncharacterized protein conserved in bacteria; hypothetical protein 214791..215237 Haemophilus influenzae PittGG 5226818 YP_001291729.1 CDS CGSHiGG_01280 NC_009567.1 215305 217227 R COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member; exodeoxyribonuclease V subunit alpha complement(215305..217227) Haemophilus influenzae PittGG 5226819 YP_001291730.1 CDS rplT NC_009567.1 220977 221330 R binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 complement(220977..221330) Haemophilus influenzae PittGG 5226820 YP_001291731.1 CDS rpmI NC_009567.1 221396 221665 R COG0291 Ribosomal protein L35; 50S ribosomal protein L35 complement(221396..221665) Haemophilus influenzae PittGG 5226821 YP_001291732.1 CDS CGSHiGG_01305 NC_009567.1 221804 222073 R COG0290 Translation initiation factor 3 (IF-3); translation initiation factor IF-3 complement(221804..222073) Haemophilus influenzae PittGG 5226822 YP_001291733.1 CDS CGSHiGG_01310 NC_009567.1 222482 223294 R related to aldose 1-epimerase; COG0676 Uncharacterized enzymes related to aldose 1-epimerase; hypothetical protein complement(222482..223294) Haemophilus influenzae PittGG 5226823 YP_001291734.1 CDS CGSHiGG_01315 NC_009567.1 223379 223816 R COG3119 Arylsulfatase A and related enzymes; arylsulfatase A-like enzyme complement(223379..223816) Haemophilus influenzae PittGG 5226824 YP_001291735.1 CDS CGSHiGG_01320 NC_009567.1 223836 225887 R COG0464 ATPases of the AAA+ class; serine/threonine protein phosphatase family protein complement(223836..225887) Haemophilus influenzae PittGG 5226825 YP_001291736.1 CDS CGSHiGG_01335 NC_009567.1 227916 229247 R COG1479 Uncharacterized conserved protein; hypothetical protein complement(227916..229247) Haemophilus influenzae PittGG 5226826 YP_001291737.1 CDS CGSHiGG_01340 NC_009567.1 229284 230036 R COG0631 Serine/threonine protein phosphatase; hypothetical protein complement(229284..230036) Haemophilus influenzae PittGG 5226827 YP_001291738.1 CDS CGSHiGG_01345 NC_009567.1 230047 230880 R COG0846 NAD-dependent protein deacetylases, SIR2 family; NAD-dependent deacetylase sirtuin 5 complement(230047..230880) Haemophilus influenzae PittGG 5226828 YP_001291739.1 CDS CGSHiGG_01350 NC_009567.1 230877 231077 R COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins; DNA translocase FtsK complement(230877..231077) Haemophilus influenzae PittGG 5226829 YP_001291740.1 CDS CGSHiGG_01365 NC_009567.1 232107 232766 R COG0846 NAD-dependent protein deacetylases, SIR2 family; NAD-dependent deacetylase complement(232107..232766) Haemophilus influenzae PittGG 5226830 YP_001291741.1 CDS CGSHiGG_01370 NC_009567.1 232750 233205 R COG4502 Uncharacterized protein conserved in bacteria; putative 5'(3')-deoxyribonucleotidase complement(232750..233205) Haemophilus influenzae PittGG 5226831 YP_001291742.1 CDS CGSHiGG_01375 NC_009567.1 233264 234034 R hypothetical protein complement(233264..234034) Haemophilus influenzae PittGG 5226832 YP_001291743.1 CDS CGSHiGG_01380 NC_009567.1 234070 234273 R COG2378 Predicted transcriptional regulator; hypothetical protein complement(234070..234273) Haemophilus influenzae PittGG 5226833 YP_001291744.1 CDS CGSHiGG_01385 NC_009567.1 234282 234767 R COG0791 Cell wall-associated hydrolases (invasion-associated proteins); lipoprotein complement(234282..234767) Haemophilus influenzae PittGG 5226834 YP_001291745.1 CDS ihfA NC_009567.1 234820 235110 R This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha complement(234820..235110) Haemophilus influenzae PittGG 5226835 YP_001291746.1 CDS pheT NC_009567.1 235112 237499 R catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta complement(235112..237499) Haemophilus influenzae PittGG 5226836 YP_001291747.1 CDS CGSHiGG_01410 NC_009567.1 238670 239410 R COG0016 Phenylalanyl-tRNA synthetase alpha subunit; hypothetical protein complement(238670..239410) Haemophilus influenzae PittGG 5226837 YP_001291748.1 CDS pheS NC_009567.1 239456 239704 D COG0633 Ferredoxin; phenylalanyl-tRNA synthetase subunit alpha 239456..239704 Haemophilus influenzae PittGG 5226838 YP_001291749.1 CDS CGSHiGG_01420 NC_009567.1 239699 240511 R catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase complement(239699..240511) Haemophilus influenzae PittGG 5226839 YP_001291750.1 CDS CGSHiGG_01425 NC_009567.1 240528 241157 R COG1280 Putative threonine efflux protein; hypothetical protein complement(240528..241157) Haemophilus influenzae PittGG 5226840 YP_001291751.1 CDS CGSHiGG_01430 NC_009567.1 241157 241648 R COG1267 Phosphatidylglycerophosphatase A and related proteins; phosphatidylglycerophosphatase A complement(241157..241648) Haemophilus influenzae PittGG 5226841 YP_001291752.1 CDS CGSHiGG_01435 NC_009567.1 241645 242631 R COG0611 Thiamine monophosphate kinase; dihydrodipicolinate reductase complement(241645..242631) Haemophilus influenzae PittGG 5226842 YP_001291753.1 CDS nusB NC_009567.1 242699 243133 R Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB complement(242699..243133) Haemophilus influenzae PittGG 5226843 YP_001291754.1 CDS ribH NC_009567.1 243137 243610 R RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase complement(243137..243610) Haemophilus influenzae PittGG 5226844 YP_001291755.1 CDS asnC NC_009567.1 243836 245239 D catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 243836..245239 Haemophilus influenzae PittGG 5226845 YP_001291756.1 CDS asnC NC_009567.1 245315 246004 D COG0288 Carbonic anhydrase; asparaginyl-tRNA synthetase 245315..246004 Haemophilus influenzae PittGG 5226846 YP_001291757.1 CDS CGSHiGG_01460 NC_009567.1 246032 247975 R Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase complement(246032..247975) Haemophilus influenzae PittGG 5226847 YP_001291758.1 CDS CGSHiGG_01465 NC_009567.1 248069 249454 R dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein complement(248069..249454) Haemophilus influenzae PittGG 5226848 YP_001291759.1 CDS CGSHiGG_01470 NC_009567.1 249666 250241 R COG1346 Putative effector of murein hydrolase; deoxyguanosinetriphosphate triphosphohydrolase-like protein complement(249666..250241) Haemophilus influenzae PittGG 5226849 YP_001291760.1 CDS CGSHiGG_01475 NC_009567.1 250260 250682 R COG1380 Putative effector of murein hydrolase LrgA; hypothetical protein complement(250260..250682) Haemophilus influenzae PittGG 5226850 YP_001291761.1 CDS CGSHiGG_01480 NC_009567.1 250818 251279 D COG1525 Micrococcal nuclease (thermonuclease) homologs; nuclease 250818..251279 Haemophilus influenzae PittGG 5226851 YP_001291762.1 CDS CGSHiGG_01485 NC_009567.1 251281 252480 D COG0520 Selenocysteine lyase; putative selenocysteine lyase 251281..252480 Haemophilus influenzae PittGG 5226852 YP_001291763.1 CDS CGSHiGG_01490 NC_009567.1 252477 252857 D COG2166 SufE protein probably involved in Fe-S center assembly; hypothetical protein 252477..252857 Haemophilus influenzae PittGG 5226853 YP_001291764.1 CDS CGSHiGG_01495 NC_009567.1 252848 253633 D COG5595 Zn-ribbon-containing, possibly nucleic-acid-binding protein; hypothetical protein 252848..253633 Haemophilus influenzae PittGG 5226854 YP_001291765.1 CDS queF NC_009567.1 253760 254599 D catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 253760..254599 Haemophilus influenzae PittGG 5226855 YP_001291766.1 CDS tyrA NC_009567.1 254632 255756 R catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase complement(254632..255756) Haemophilus influenzae PittGG 5226856 YP_001291767.1 CDS truB NC_009567.1 255845 256765 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(255845..256765) Haemophilus influenzae PittGG 5226857 YP_001291768.1 CDS CGSHiGG_01525 NC_009567.1 257317 258993 D putative type I restriction enzyme HindVIIP M protein 257317..258993 Haemophilus influenzae PittGG 5226858 YP_001291769.1 CDS CGSHiGG_01530 NC_009567.1 258986 260365 D putative type I restriction enzyme HindVIIP specificity protein 258986..260365 Haemophilus influenzae PittGG 5226859 YP_001291770.1 CDS CGSHiGG_01535 NC_009567.1 260367 260891 D COG0732 Restriction endonuclease S subunits; hypothetical protein 260367..260891 Haemophilus influenzae PittGG 5226860 YP_001291771.1 CDS CGSHiGG_01540 NC_009567.1 260928 261173 D hypothetical protein 260928..261173 Haemophilus influenzae PittGG 5226861 YP_001291772.1 CDS CGSHiGG_01545 NC_009567.1 261357 261683 D COG1338 Flagellar biosynthesis pathway, component FliP; hypothetical protein 261357..261683 Haemophilus influenzae PittGG 5226862 YP_001291773.1 CDS infB NC_009567.1 265042 267576 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(265042..267576) Haemophilus influenzae PittGG 5226863 YP_001291774.1 CDS nusA NC_009567.1 267588 269075 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(267588..269075) Haemophilus influenzae PittGG 5226864 YP_001291775.1 CDS CGSHiGG_01570 NC_009567.1 269092 269547 R in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein complement(269092..269547) Haemophilus influenzae PittGG 5226865 YP_001291777.1 CDS CGSHiGG_01580 NC_009567.1 270942 271058 R COG2801 Transposase and inactivated derivatives; transposase complement(270942..271058) Haemophilus influenzae PittGG 5226867 YP_001291778.1 CDS CGSHiGG_01585 NC_009567.1 271536 272210 R COG1083 CMP-N-acetylneuraminic acid synthetase; acylneuraminate cytidylyltransferase complement(271536..272210) Haemophilus influenzae PittGG 5226868 YP_001291779.1 CDS CGSHiGG_01590 NC_009567.1 272324 272971 D COG0778 Nitroreductase; hypothetical protein 272324..272971 Haemophilus influenzae PittGG 5226869 YP_001291780.1 CDS CGSHiGG_01595 NC_009567.1 273033 274145 R COG0489 ATPases involved in chromosome partitioning; putative ATPase complement(273033..274145) Haemophilus influenzae PittGG 5226870 YP_001291781.1 CDS metG NC_009567.1 274296 276344 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 274296..276344 Haemophilus influenzae PittGG 5226871 YP_001291782.1 CDS CGSHiGG_01615 NC_009567.1 277368 278099 R COG0491 Zn-dependent hydrolases, including glyoxylases; hydroxyacylglutathione hydrolase complement(277368..278099) Haemophilus influenzae PittGG 5226872 YP_001291783.1 CDS CGSHiGG_01645 NC_009567.1 279719 279853 R COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components; hypothetical protein complement(279719..279853) Haemophilus influenzae PittGG 5226873 YP_001291784.1 CDS CGSHiGG_01650 NC_009567.1 279825 280688 R COG0609 ABC-type Fe3+-siderophore transport system, permease component; ABC transporter permease complement(279825..280688) Haemophilus influenzae PittGG 5226874 YP_001291785.1 CDS CGSHiGG_01655 NC_009567.1 280734 281279 R periplasmic binding protein complement(280734..281279) Haemophilus influenzae PittGG 5226875 YP_001291786.1 CDS CGSHiGG_01660 NC_009567.1 281315 281635 D COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component; hypothetical protein 281315..281635 Haemophilus influenzae PittGG 5226876 YP_001291787.1 CDS metX NC_009567.1 286802 287692 R Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase complement(286802..287692) Haemophilus influenzae PittGG 5226877 YP_001291788.1 CDS CGSHiGG_01690 NC_009567.1 287993 288673 D COG2949 Uncharacterized membrane protein; hypothetical protein 287993..288673 Haemophilus influenzae PittGG 5226878 YP_001291789.1 CDS CGSHiGG_01705 NC_009567.1 290266 291156 R catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta complement(290266..291156) Haemophilus influenzae PittGG 5226879 YP_001291790.1 CDS CGSHiGG_01720 NC_009567.1 292794 296234 R transcription-repair coupling factor complement(292794..296234) Haemophilus influenzae PittGG 5226880 YP_001291791.1 CDS CGSHiGG_01725 NC_009567.1 296337 296510 R COG1197 Transcription-repair coupling factor (superfamily II helicase); hypothetical protein complement(296337..296510) Haemophilus influenzae PittGG 5226881 YP_001291792.1 CDS CGSHiGG_01730 NC_009567.1 296507 298351 R COG1444 Predicted P-loop ATPase fused to an acetyltransferase; P-loop ATPase fused to an acetyltransferase complement(296507..298351) Haemophilus influenzae PittGG 5226882 YP_001291793.1 CDS CGSHiGG_01735 NC_009567.1 298356 298652 R COG3094 Uncharacterized protein conserved in bacteria; hypothetical protein complement(298356..298652) Haemophilus influenzae PittGG 5226883 YP_001291794.1 CDS CGSHiGG_01740 NC_009567.1 298758 300428 R ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein complement(298758..300428) Haemophilus influenzae PittGG 5226884 YP_001291795.1 CDS CGSHiGG_01745 NC_009567.1 300593 300916 R COG3093 Plasmid maintenance system antidote protein; plasmid maintenance system antidote protein complement(300593..300916) Haemophilus influenzae PittGG 5226885 YP_001291796.1 CDS CGSHiGG_01750 NC_009567.1 300927 301232 R COG3549 Plasmid maintenance system killer protein; plasmid maintenance system killer protein complement(300927..301232) Haemophilus influenzae PittGG 5226886 YP_001291797.1 CDS CGSHiGG_01775 NC_009567.1 303961 305799 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 303961..305799 Haemophilus influenzae PittGG 5226887 YP_001291798.1 CDS CGSHiGG_01780 NC_009567.1 305830 307773 R COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily; excinuclease ABC subunit B complement(305830..307773) Haemophilus influenzae PittGG 5226888 YP_001291799.1 CDS CGSHiGG_01785 NC_009567.1 307991 310261 R NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme complement(307991..310261) Haemophilus influenzae PittGG 5226889 YP_001291800.1 CDS CGSHiGG_01790 NC_009567.1 310459 311079 D COG3955 Exopolysaccharide biosynthesis protein; hypothetical protein 310459..311079 Haemophilus influenzae PittGG 5226890 YP_001291801.1 CDS CGSHiGG_01795 NC_009567.1 311170 311868 D COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; malic enzyme 311170..311868 Haemophilus influenzae PittGG 5226891 YP_001291802.1 CDS CGSHiGG_01800 NC_009567.1 311870 313066 D Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system 311870..313066 Haemophilus influenzae PittGG 5226892 YP_001291803.1 CDS CGSHiGG_01805 NC_009567.1 313098 313898 R COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; hypothetical protein complement(313098..313898) Haemophilus influenzae PittGG 5226893 YP_001291804.1 CDS CGSHiGG_01810 NC_009567.1 313996 314658 D COG2860 Predicted membrane protein; bicyclomycin/multidrug efflux system 313996..314658 Haemophilus influenzae PittGG 5226894 YP_001291805.1 CDS proA NC_009567.1 314679 315932 D Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 314679..315932 Haemophilus influenzae PittGG 5226895 YP_001291806.1 CDS CGSHiGG_01820 NC_009567.1 316011 317159 R chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ complement(316011..317159) Haemophilus influenzae PittGG 5226896 YP_001291807.1 CDS dnaK NC_009567.1 317386 319293 R heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK complement(317386..319293) Haemophilus influenzae PittGG 5226897 YP_001291808.1 CDS proA NC_009567.1 319546 320988 D COG5339 Uncharacterized protein conserved in bacteria; hypothetical protein 319546..320988 Haemophilus influenzae PittGG 5226898 YP_001291809.1 CDS mgsA NC_009567.1 321133 321591 R catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase complement(321133..321591) Haemophilus influenzae PittGG 5226899 YP_001291810.1 CDS aceE NC_009567.1 321890 324550 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 321890..324550 Haemophilus influenzae PittGG 5226900 YP_001291811.1 CDS CGSHiGG_01845 NC_009567.1 324613 326274 D COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes; dihydrolipoamide acetyltransferase 324613..326274 Haemophilus influenzae PittGG 5226901 YP_001291812.1 CDS CGSHiGG_01850 NC_009567.1 326388 327812 D E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 326388..327812 Haemophilus influenzae PittGG 5226902 YP_001291813.1 CDS CGSHiGG_01855 NC_009567.1 327970 328512 D catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 327970..328512 Haemophilus influenzae PittGG 5226903 YP_001291814.1 CDS CGSHiGG_01860 NC_009567.1 328524 330590 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 328524..330590 Haemophilus influenzae PittGG 5226904 YP_001291815.1 CDS upp NC_009567.1 330713 331339 D Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 330713..331339 Haemophilus influenzae PittGG 5226905 YP_001291816.1 CDS upp NC_009567.1 331443 332687 D COG2233 Xanthine/uracil permeases; uracil phosphoribosyltransferase 331443..332687 Haemophilus influenzae PittGG 5226906 YP_001291817.1 CDS CGSHiGG_01875 NC_009567.1 332888 333445 D COG0593 ATPase involved in DNA replication initiation; DNA replication initiation factor 332888..333445 Haemophilus influenzae PittGG 5226907 YP_001291818.1 CDS CGSHiGG_01880 NC_009567.1 333474 333794 R involved in start site selection during the initiation of translation; translation initiation factor Sui1 complement(333474..333794) Haemophilus influenzae PittGG 5226908 YP_001291819.1 CDS CGSHiGG_01885 NC_009567.1 333801 334475 R type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase complement(333801..334475) Haemophilus influenzae PittGG 5226909 YP_001291820.1 CDS CGSHiGG_01890 NC_009567.1 334518 335708 R COG2956 Predicted N-acetylglucosaminyl transferase; tetratricopeptide repeat protein complement(334518..335708) Haemophilus influenzae PittGG 5226910 YP_001291821.1 CDS CGSHiGG_01895 NC_009567.1 335708 336001 R COG3771 Predicted membrane protein; hypothetical protein complement(335708..336001) Haemophilus influenzae PittGG 5226911 YP_001291822.1 CDS ihfB NC_009567.1 336076 336360 R This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta complement(336076..336360) Haemophilus influenzae PittGG 5226912 YP_001291823.1 CDS rpsA NC_009567.1 336483 338132 R in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 complement(336483..338132) Haemophilus influenzae PittGG 5226913 YP_001291824.1 CDS cmk NC_009567.1 338229 338906 R Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase complement(338229..338906) Haemophilus influenzae PittGG 5226914 YP_001291825.1 CDS CGSHiGG_01915 NC_009567.1 339375 340250 D with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 339375..340250 Haemophilus influenzae PittGG 5226915 YP_001291826.1 CDS CGSHiGG_01920 NC_009567.1 340251 340829 D with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 340251..340829 Haemophilus influenzae PittGG 5226916 YP_001291827.1 CDS CGSHiGG_01925 NC_009567.1 341378 343072 R component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase complement(341378..343072) Haemophilus influenzae PittGG 5226917 YP_001291828.1 CDS CGSHiGG_01930 NC_009567.1 343331 343441 D COG0277 FAD/FMN-containing dehydrogenases; hypothetical protein 343331..343441 Haemophilus influenzae PittGG 5226918 YP_001291829.1 CDS CGSHiGG_01945 NC_009567.1 344644 346092 R COG0312 Predicted Zn-dependent proteases and their inactivated homologs; hypothetical protein complement(344644..346092) Haemophilus influenzae PittGG 5226919 YP_001291830.1 CDS CGSHiGG_01950 NC_009567.1 346194 347045 R COG0313 Predicted methyltransferases; methyltransferase complement(346194..347045) Haemophilus influenzae PittGG 5226920 YP_001291831.1 CDS CGSHiGG_01955 NC_009567.1 347117 348844 D COG3107 Putative lipoprotein; D-lactate dehydrogenase 347117..348844 Haemophilus influenzae PittGG 5226921 YP_001291832.1 CDS CGSHiGG_01960 NC_009567.1 348844 349203 D COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase; hypothetical protein 348844..349203 Haemophilus influenzae PittGG 5226922 YP_001291833.1 CDS CGSHiGG_01965 NC_009567.1 349216 349800 D COG0279 Phosphoheptose isomerase; hypothetical protein 349216..349800 Haemophilus influenzae PittGG 5226923 YP_001291834.1 CDS CGSHiGG_01970 NC_009567.1 349857 350438 D COG2823 Predicted periplasmic or secreted lipoprotein; hypothetical protein 349857..350438 Haemophilus influenzae PittGG 5226924 YP_001291835.1 CDS nrdB NC_009567.1 354277 355506 R COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes; ribonucleotide-diphosphate reductase subunit beta complement(354277..355506) Haemophilus influenzae PittGG 5226925 YP_001291836.1 CDS sucA NC_009567.1 355628 358435 R SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component complement(355628..358435) Haemophilus influenzae PittGG 5226926 YP_001291837.1 CDS CGSHiGG_02005 NC_009567.1 358658 359158 R COG0790 FOG: TPR repeat, SEL1 subfamily; hypothetical protein complement(358658..359158) Haemophilus influenzae PittGG 5226927 YP_001291838.1 CDS CGSHiGG_02010 NC_009567.1 359180 359923 R hypothetical protein complement(359180..359923) Haemophilus influenzae PittGG 5226928 YP_001291839.1 CDS CGSHiGG_02015 NC_009567.1 359936 360289 R hypothetical protein complement(359936..360289) Haemophilus influenzae PittGG 5226929 YP_001291840.1 CDS CGSHiGG_02020 NC_009567.1 360371 361213 R hypothetical protein complement(360371..361213) Haemophilus influenzae PittGG 5226930 YP_001291841.1 CDS CGSHiGG_02025 NC_009567.1 361227 361499 R hypothetical protein complement(361227..361499) Haemophilus influenzae PittGG 5226931 YP_001291842.1 CDS CGSHiGG_02030 NC_009567.1 361645 361716 R hypothetical protein complement(361645..361716) Haemophilus influenzae PittGG 5226932 YP_001291843.1 CDS CGSHiGG_02035 NC_009567.1 361774 362037 R COG0790 FOG: TPR repeat, SEL1 subfamily; hypothetical protein complement(361774..362037) Haemophilus influenzae PittGG 5226933 YP_001291844.1 CDS CGSHiGG_02040 NC_009567.1 362124 362762 R hypothetical protein complement(362124..362762) Haemophilus influenzae PittGG 5226934 YP_001291845.1 CDS CGSHiGG_02055 NC_009567.1 363578 364138 R COG3108 Uncharacterized protein conserved in bacteria; hypothetical protein complement(363578..364138) Haemophilus influenzae PittGG 5226935 YP_001291846.1 CDS kgd NC_009567.1 364154 365623 R COG2989 Uncharacterized protein conserved in bacteria; hypothetical protein complement(364154..365623) Haemophilus influenzae PittGG 5226936 YP_001291847.1 CDS CGSHiGG_02065 NC_009567.1 365690 367777 R Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease complement(365690..367777) Haemophilus influenzae PittGG 5226937 YP_001291848.1 CDS CGSHiGG_02070 NC_009567.1 367805 368443 R affects solute and DNA transport through an unknown mechanism; putative solute/DNA competence effector complement(367805..368443) Haemophilus influenzae PittGG 5226938 YP_001291849.1 CDS CGSHiGG_02075 NC_009567.1 368563 368694 R COG3109 Activator of osmoprotectant transporter ProP; hypothetical protein complement(368563..368694) Haemophilus influenzae PittGG 5226939 YP_001291850.1 CDS CGSHiGG_02100 NC_009567.1 372569 373021 R COG0314 Molybdopterin converting factor, large subunit; molybdopterin converting factor subunit 2 complement(372569..373021) Haemophilus influenzae PittGG 5226940 YP_001291851.1 CDS moaD NC_009567.1 373022 373267 R catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit complement(373022..373267) Haemophilus influenzae PittGG 5226941 YP_001291852.1 CDS moaC NC_009567.1 373269 373751 R MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC complement(373269..373751) Haemophilus influenzae PittGG 5226942 YP_001291853.1 CDS moaA NC_009567.1 373843 374856 R together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A complement(373843..374856) Haemophilus influenzae PittGG 5226943 YP_001291854.1 CDS CGSHiGG_02120 NC_009567.1 375301 375972 D Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein 375301..375972 Haemophilus influenzae PittGG 5226944 YP_001291855.1 CDS CGSHiGG_02125 NC_009567.1 376587 377522 D COG0794 Predicted sugar phosphate isomerase involved in capsule formation; arabinose-5-phosphate isomerase 376587..377522 Haemophilus influenzae PittGG 5226945 YP_001291856.1 CDS CGSHiGG_02130 NC_009567.1 377532 378074 D COG1778 Low specificity phosphatase (HAD superfamily); phosphatase 377532..378074 Haemophilus influenzae PittGG 5226946 YP_001291857.1 CDS moaA NC_009567.1 378172 380328 R COG1289 Predicted membrane protein; molybdenum cofactor biosynthesis protein A complement(378172..380328) Haemophilus influenzae PittGG 5226947 YP_001291858.1 CDS CGSHiGG_02140 NC_009567.1 380396 381061 R COG3110 Uncharacterized protein conserved in bacteria; hypothetical protein complement(380396..381061) Haemophilus influenzae PittGG 5226948 YP_001291859.1 CDS CGSHiGG_02155 NC_009567.1 382604 383182 D COG4657 Predicted NADH:ubiquinone oxidoreductase, subunit RnfA; Na(+)-translocating NADH-quinone reductase subunit E 382604..383182 Haemophilus influenzae PittGG 5226949 YP_001291860.1 CDS CGSHiGG_02160 NC_009567.1 383270 383926 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 383270..383926 Haemophilus influenzae PittGG 5226950 YP_001291861.1 CDS CGSHiGG_02165 NC_009567.1 383923 385974 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 383923..385974 Haemophilus influenzae PittGG 5226951 YP_001291862.1 CDS rnfD NC_009567.1 385979 387055 D RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 385979..387055 Haemophilus influenzae PittGG 5226952 YP_001291863.1 CDS CGSHiGG_02175 NC_009567.1 387055 387597 D part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 387055..387597 Haemophilus influenzae PittGG 5226953 YP_001291864.1 CDS CGSHiGG_02180 NC_009567.1 387679 388383 D in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex RsxE subunit 387679..388383 Haemophilus influenzae PittGG 5226954 YP_001291865.1 CDS CGSHiGG_02185 NC_009567.1 388504 389139 D COG0177 Predicted EndoIII-related endonuclease; endonuclease III 388504..389139 Haemophilus influenzae PittGG 5226955 YP_001291866.1 CDS CGSHiGG_02190 NC_009567.1 389198 390571 D COG0733 Na+-dependent transporters of the SNF family; SoxR-reducing system protein RsxE 389198..390571 Haemophilus influenzae PittGG 5226956 YP_001291867.1 CDS modC NC_009567.1 390595 391650 R Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein complement(390595..391650) Haemophilus influenzae PittGG 5226957 YP_001291868.1 CDS modB NC_009567.1 391637 392365 R part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease protein complement(391637..392365) Haemophilus influenzae PittGG 5226958 YP_001291869.1 CDS CGSHiGG_02205 NC_009567.1 392500 393264 R COG0725 ABC-type molybdate transport system, periplasmic component; molybdate-binding periplasmic protein complement(392500..393264) Haemophilus influenzae PittGG 5226959 YP_001291870.1 CDS CGSHiGG_02210 NC_009567.1 393402 394169 D COG2005 N-terminal domain of molybdenum-binding protein; molybdenum transport protein 393402..394169 Haemophilus influenzae PittGG 5226960 YP_001291871.1 CDS CGSHiGG_02215 NC_009567.1 394279 395082 R COG0463 Glycosyltransferases involved in cell wall biogenesis; putative UDP-galactose--lipooligosaccharide galactosyltransferase complement(394279..395082) Haemophilus influenzae PittGG 5226961 YP_001291872.1 CDS CGSHiGG_02230 NC_009567.1 396175 396750 R COG3306 Glycosyltransferase involved in LPS biosynthesis; putative UDP-GlcNAc--lipooligosaccharide N-acetylglucosaminyl glycosyltransferase complement(396175..396750) Haemophilus influenzae PittGG 5226962 YP_001291873.1 CDS CGSHiGG_02235 NC_009567.1 396762 397652 R lipopolysaccharide biosynthesis protein complement(396762..397652) Haemophilus influenzae PittGG 5226963 YP_001291874.1 CDS CGSHiGG_02240 NC_009567.1 397649 397822 R COG0438 Glycosyltransferase; hypothetical protein complement(397649..397822) Haemophilus influenzae PittGG 5226964 YP_001291875.1 CDS CGSHiGG_02245 NC_009567.1 397824 398738 R COG1112 Superfamily I DNA and RNA helicases and helicase subunits; lipopolysaccharide biosynthesis protein complement(397824..398738) Haemophilus influenzae PittGG 5226965 YP_001291876.1 CDS CGSHiGG_02250 NC_009567.1 398735 399940 R COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; lipopolysaccharide biosynthesis protein complement(398735..399940) Haemophilus influenzae PittGG 5226966 YP_001291877.1 CDS modB NC_009567.1 400074 400817 D COG1434 Uncharacterized conserved protein; hypothetical protein 400074..400817 Haemophilus influenzae PittGG 5226967 YP_001291878.1 CDS CGSHiGG_02260 NC_009567.1 401039 403309 R catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase complement(401039..403309) Haemophilus influenzae PittGG 5226968 YP_001291879.1 CDS CGSHiGG_02265 NC_009567.1 403503 404579 R COG0795 Predicted permeases; permease complement(403503..404579) Haemophilus influenzae PittGG 5226969 YP_001291880.1 CDS CGSHiGG_02270 NC_009567.1 404576 405679 R COG0795 Predicted permeases; 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase complement(404576..405679) Haemophilus influenzae PittGG 5226970 YP_001291881.1 CDS CGSHiGG_02275 NC_009567.1 405786 407261 D catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 405786..407261 Haemophilus influenzae PittGG 5226971 YP_001291882.1 CDS CGSHiGG_02280 NC_009567.1 407297 409324 R COG1292 Choline-glycine betaine transporter; choline-glycine betaine transporter complement(407297..409324) Haemophilus influenzae PittGG 5226972 YP_001291883.1 CDS CGSHiGG_02285 NC_009567.1 409601 410956 R COG0642 Signal transduction histidine kinase; sensor protein QseC complement(409601..410956) Haemophilus influenzae PittGG 5226973 YP_001291884.1 CDS CGSHiGG_02290 NC_009567.1 410953 411618 R COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; transcriptional regulatory protein complement(410953..411618) Haemophilus influenzae PittGG 5226974 YP_001291885.1 CDS CGSHiGG_02295 NC_009567.1 411681 412046 R hypothetical protein complement(411681..412046) Haemophilus influenzae PittGG 5226975 YP_001291886.1 CDS CGSHiGG_02300 NC_009567.1 412161 412256 R COG3111 Uncharacterized conserved protein; leucyl aminopeptidase complement(412161..412256) Haemophilus influenzae PittGG 5226976 YP_001291887.1 CDS CGSHiGG_02305 NC_009567.1 412393 412893 R functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter subunit complement(412393..412893) Haemophilus influenzae PittGG 5226977 YP_001291888.1 CDS CGSHiGG_02310 NC_009567.1 412953 414680 R Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase complement(412953..414680) Haemophilus influenzae PittGG 5226978 YP_001291889.1 CDS CGSHiGG_02315 NC_009567.1 414760 415017 R COG1925 Phosphotransferase system, HPr-related proteins; phosphoenolpyruvate-protein phosphotransferase complement(414760..415017) Haemophilus influenzae PittGG 5226979 YP_001291890.1 CDS CGSHiGG_02320 NC_009567.1 415175 416215 R EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase complement(415175..416215) Haemophilus influenzae PittGG 5226980 YP_001291891.1 CDS CGSHiGG_02325 NC_009567.1 416285 416833 D 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 416285..416833 Haemophilus influenzae PittGG 5226981 YP_001291892.1 CDS CGSHiGG_02330 NC_009567.1 417135 418202 R COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase; oligoribonuclease complement(417135..418202) Haemophilus influenzae PittGG 5226982 YP_001291893.1 CDS CGSHiGG_02345 NC_009567.1 420964 421770 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase complement(420964..421770) Haemophilus influenzae PittGG 5226983 YP_001291894.1 CDS CGSHiGG_02350 NC_009567.1 421906 422250 D essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 421906..422250 Haemophilus influenzae PittGG 5226984 YP_001291895.1 CDS CGSHiGG_02355 NC_009567.1 422303 422605 D COG3112 Uncharacterized protein conserved in bacteria; hypothetical protein 422303..422605 Haemophilus influenzae PittGG 5226985 YP_001291896.1 CDS CGSHiGG_02365 NC_009567.1 425130 426002 D catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 425130..426002 Haemophilus influenzae PittGG 5226988 YP_001291897.1 CDS CGSHiGG_02370 NC_009567.1 426158 427492 D catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 426158..427492 Haemophilus influenzae PittGG 5226989 YP_001291898.1 CDS CGSHiGG_02375 NC_009567.1 427563 428756 R COG1914 Mn2+ and Fe2+ transporters of the NRAMP family; argininosuccinate synthase complement(427563..428756) Haemophilus influenzae PittGG 5226990 YP_001291899.1 CDS CGSHiGG_02380 NC_009567.1 428800 429537 R COG1540 Uncharacterized proteins, homologs of lactam utilization protein B; LamB/YcsF family protein complement(428800..429537) Haemophilus influenzae PittGG 5226991 YP_001291900.1 CDS CGSHiGG_02395 NC_009567.1 430449 431090 R COG2049 Allophanate hydrolase subunit 1; hypothetical protein complement(430449..431090) Haemophilus influenzae PittGG 5226992 YP_001291901.1 CDS CGSHiGG_02400 NC_009567.1 431323 431931 R COG5295 Autotransporter adhesin; hypothetical protein complement(431323..431931) Haemophilus influenzae PittGG 5226993 YP_001291902.1 CDS CGSHiGG_02405 NC_009567.1 431909 433888 R Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II complement(431909..433888) Haemophilus influenzae PittGG 5226994 YP_001291903.1 CDS CGSHiGG_02410 NC_009567.1 434056 434760 R COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH); exoribonuclease II complement(434056..434760) Haemophilus influenzae PittGG 5226995 YP_001291904.1 CDS prfC NC_009567.1 434939 436522 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 434939..436522 Haemophilus influenzae PittGG 5226996 YP_001291905.1 CDS CGSHiGG_02420 NC_009567.1 436935 437264 R COG1687 Predicted branched-chain amino acid permeases (azaleucine resistance); putative branched-chain amino acid permease complement(436935..437264) Haemophilus influenzae PittGG 5226997 YP_001291906.1 CDS CGSHiGG_02425 NC_009567.1 437261 437995 R COG1296 Predicted branched-chain amino acid permease (azaleucine resistance); putative branched-chain amino acid permease complement(437261..437995) Haemophilus influenzae PittGG 5226998 YP_001291907.1 CDS prfC NC_009567.1 438005 438934 R COG0583 Transcriptional regulator; peptide chain release factor 3 complement(438005..438934) Haemophilus influenzae PittGG 5226999 YP_001291908.1 CDS lldD NC_009567.1 444978 446123 R flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase complement(444978..446123) Haemophilus influenzae PittGG 5227002 YP_001291909.1 CDS CGSHiGG_02440 NC_009567.1 446335 447144 R converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase complement(446335..447144) Haemophilus influenzae PittGG 5227003 YP_001291910.1 CDS CGSHiGG_02445 NC_009567.1 447174 449255 R catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG complement(447174..449255) Haemophilus influenzae PittGG 5227004 YP_001291911.1 CDS CGSHiGG_02450 NC_009567.1 449252 451366 R COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; glutamate racemase complement(449252..451366) Haemophilus influenzae PittGG 5227005 YP_001291912.1 CDS rpoZ NC_009567.1 451439 451705 R promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega complement(451439..451705) Haemophilus influenzae PittGG 5227006 YP_001291913.1 CDS gmk NC_009567.1 451767 452393 R Essential for recycling GMP and indirectly, cGMP; guanylate kinase complement(451767..452393) Haemophilus influenzae PittGG 5227007 YP_001291914.1 CDS CGSHiGG_02465 NC_009567.1 452644 453663 D COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase 452644..453663 Haemophilus influenzae PittGG 5227008 YP_001291915.1 CDS CGSHiGG_02470 NC_009567.1 453858 455657 D COG1022 Long-chain acyl-CoA synthetases (AMP-forming); long chain fatty acid CoA ligase 453858..455657 Haemophilus influenzae PittGG 5227009 YP_001291916.1 CDS gmk NC_009567.1 455694 456479 R COG0561 Predicted hydrolases of the HAD superfamily; guanylate kinase complement(455694..456479) Haemophilus influenzae PittGG 5227010 YP_001291917.1 CDS CGSHiGG_02480 NC_009567.1 456498 456962 R COG0319 Predicted metal-dependent hydrolase; putative metalloprotease complement(456498..456962) Haemophilus influenzae PittGG 5227011 YP_001291918.1 CDS CGSHiGG_02485 NC_009567.1 457220 458032 R involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein complement(457220..458032) Haemophilus influenzae PittGG 5227012 YP_001291919.1 CDS CGSHiGG_02490 NC_009567.1 458303 458914 D COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; formate dehydrogenase major subunit 458303..458914 Haemophilus influenzae PittGG 5227013 YP_001291920.1 CDS CGSHiGG_02495 NC_009567.1 458963 461389 D COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; formate dehydrogenase major subunit 458963..461389 Haemophilus influenzae PittGG 5227014 YP_001291921.1 CDS CGSHiGG_02500 NC_009567.1 461391 463037 D COG0437 Fe-S-cluster-containing hydrogenase components 1; formate dehydrogenase accessory protein 461391..463037 Haemophilus influenzae PittGG 5227015 YP_001291922.1 CDS CGSHiGG_02505 NC_009567.1 463107 464015 D required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 463107..464015 Haemophilus influenzae PittGG 5227016 YP_001291923.1 CDS rimI NC_009567.1 464054 464521 R alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase complement(464054..464521) Haemophilus influenzae PittGG 5227017 YP_001291924.1 CDS CGSHiGG_02515 NC_009567.1 464497 464901 R with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi complement(464497..464901) Haemophilus influenzae PittGG 5227018 YP_001291925.1 CDS rsmC NC_009567.1 465007 465999 D 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase 465007..465999 Haemophilus influenzae PittGG 5227019 YP_001291926.1 CDS era NC_009567.1 466063 466785 R COG1159 GTPase; GTP-binding protein Era complement(466063..466785) Haemophilus influenzae PittGG 5227020 YP_001291927.1 CDS rnc NC_009567.1 466967 467650 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(466967..467650) Haemophilus influenzae PittGG 5227021 YP_001291928.1 CDS CGSHiGG_02545 NC_009567.1 468712 470508 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(468712..470508) Haemophilus influenzae PittGG 5227022 YP_001291929.1 CDS CGSHiGG_02550 NC_009567.1 470677 471060 R stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA complement(470677..471060) Haemophilus influenzae PittGG 5227023 YP_001291930.1 CDS CGSHiGG_02565 NC_009567.1 472060 473484 R catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase complement(472060..473484) Haemophilus influenzae PittGG 5227024 YP_001291931.1 CDS CGSHiGG_02570 NC_009567.1 473904 475343 R COG0471 Di- and tricarboxylate transporters; hypothetical protein complement(473904..475343) Haemophilus influenzae PittGG 5227025 YP_001291932.1 CDS CGSHiGG_02575 NC_009567.1 475345 476568 R COG3697 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase); ATP:dephospho-CoA triphosphoribosyl transferase CitG complement(475345..476568) Haemophilus influenzae PittGG 5227026 YP_001291933.1 CDS CGSHiGG_02580 NC_009567.1 476541 476741 R COG3697 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase); hypothetical protein complement(476541..476741) Haemophilus influenzae PittGG 5227027 YP_001291934.1 CDS CGSHiGG_02600 NC_009567.1 478437 479312 R COG2301 Citrate lyase beta subunit; citrate lyase beta chain complement(478437..479312) Haemophilus influenzae PittGG 5227028 YP_001291935.1 CDS CGSHiGG_02605 NC_009567.1 479309 479596 R acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma complement(479309..479596) Haemophilus influenzae PittGG 5227029 YP_001291936.1 CDS CGSHiGG_02610 NC_009567.1 479634 480641 R COG3053 Citrate lyase synthetase; uracil-DNA glycosylase complement(479634..480641) Haemophilus influenzae PittGG 5227030 YP_001291937.1 CDS CGSHiGG_02615 NC_009567.1 481018 481980 R catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase complement(481018..481980) Haemophilus influenzae PittGG 5227031 YP_001291938.1 CDS lipB NC_009567.1 482034 482672 R lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B complement(482034..482672) Haemophilus influenzae PittGG 5227032 YP_001291939.1 CDS CGSHiGG_02625 NC_009567.1 482674 482952 R COG2921 Uncharacterized conserved protein; hypothetical protein complement(482674..482952) Haemophilus influenzae PittGG 5227033 YP_001291940.1 CDS CGSHiGG_02650 NC_009567.1 485121 486236 R COG0772 Bacterial cell division membrane protein; rod shape-determining protein complement(485121..486236) Haemophilus influenzae PittGG 5227034 YP_001291941.1 CDS CGSHiGG_02655 NC_009567.1 486226 488181 R COG0768 Cell division protein FtsI/penicillin-binding protein 2; penicillin-binding protein 2 complement(486226..488181) Haemophilus influenzae PittGG 5227035 YP_001291942.1 CDS CGSHiGG_02660 NC_009567.1 488203 488670 R SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(488203..488670) Haemophilus influenzae PittGG 5227036 YP_001291943.1 CDS CGSHiGG_02665 NC_009567.1 488724 489032 R COG0799 Uncharacterized homolog of plant Iojap protein; hypothetical protein complement(488724..489032) Haemophilus influenzae PittGG 5227037 YP_001291944.1 CDS CGSHiGG_02670 NC_009567.1 489157 490812 R COG2985 Predicted permease; hypothetical protein complement(489157..490812) Haemophilus influenzae PittGG 5227038 YP_001291945.1 CDS CGSHiGG_02675 NC_009567.1 491018 492796 D COG4178 ABC-type uncharacterized transport system, permease and ATPase components; ABC transporter ATP-binding protein 491018..492796 Haemophilus influenzae PittGG 5227039 YP_001291946.1 CDS CGSHiGG_02680 NC_009567.1 492926 493981 D functions in MreBCD complex in some organisms; rod shape-determining protein MreB 492926..493981 Haemophilus influenzae PittGG 5227040 YP_001291947.1 CDS CGSHiGG_02685 NC_009567.1 494061 495116 D in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 494061..495116 Haemophilus influenzae PittGG 5227041 YP_001291948.1 CDS CGSHiGG_02690 NC_009567.1 495116 495604 D COG2891 Cell shape-determining protein; rod shape-determining protein MreD 495116..495604 Haemophilus influenzae PittGG 5227042 YP_001291949.1 CDS CGSHiGG_02695 NC_009567.1 495655 496431 R COG3076 Uncharacterized protein conserved in bacteria; hypothetical protein complement(495655..496431) Haemophilus influenzae PittGG 5227043 YP_001291950.1 CDS CGSHiGG_02700 NC_009567.1 496441 497244 R removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III complement(496441..497244) Haemophilus influenzae PittGG 5227044 YP_001291951.1 CDS CGSHiGG_02705 NC_009567.1 497292 497966 R COG0564 Pseudouridylate synthases, 23S RNA-specific; exonuclease III complement(497292..497966) Haemophilus influenzae PittGG 5227045 YP_001291952.1 CDS CGSHiGG_02710 NC_009567.1 497966 499030 R COG3768 Predicted membrane protein; hypothetical protein complement(497966..499030) Haemophilus influenzae PittGG 5227046 YP_001291953.1 CDS CGSHiGG_02715 NC_009567.1 499087 499749 R COG0670 Integral membrane protein, interacts with FtsH; FtsH-interacting integral membrane protein complement(499087..499749) Haemophilus influenzae PittGG 5227047 YP_001291954.1 CDS CGSHiGG_02720 NC_009567.1 500076 500630 R COG3054 Predicted transcriptional regulator; hypothetical protein complement(500076..500630) Haemophilus influenzae PittGG 5227048 YP_001291955.1 CDS CGSHiGG_02725 NC_009567.1 500734 501060 D COG2824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism; hypothetical protein 500734..501060 Haemophilus influenzae PittGG 5227049 YP_001291956.1 CDS CGSHiGG_02740 NC_009567.1 501762 503165 R catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase complement(501762..503165) Haemophilus influenzae PittGG 5227050 YP_001291957.1 CDS CGSHiGG_02745 NC_009567.1 503234 504637 R COG2211 Na+/melibiose symporter and related transporters; glucuronide permease complement(503234..504637) Haemophilus influenzae PittGG 5227051 YP_001291958.1 CDS CGSHiGG_02750 NC_009567.1 504656 506416 R COG1472 Beta-glucosidase-related glycosidases; beta-hexosamidase A complement(504656..506416) Haemophilus influenzae PittGG 5227052 YP_001291959.1 CDS CGSHiGG_02755 NC_009567.1 506427 507308 R COG0546 Predicted phosphatases; glucuronate isomerase complement(506427..507308) Haemophilus influenzae PittGG 5227053 YP_001291960.1 CDS CGSHiGG_02760 NC_009567.1 507277 508122 R Converts D-mannonate to D-mannuronate; D-mannonate oxidoreductase complement(507277..508122) Haemophilus influenzae PittGG 5227055 YP_001291961.1 CDS CGSHiGG_02765 NC_009567.1 508477 508749 D COG3676 Transposase and inactivated derivatives; putative transposase-like protein 508477..508749 Haemophilus influenzae PittGG 5227056 YP_001291962.1 CDS CGSHiGG_02770 NC_009567.1 508850 509605 D COG2186 Transcriptional regulators; D-mannonate oxidoreductase 508850..509605 Haemophilus influenzae PittGG 5227057 YP_001291963.1 CDS CGSHiGG_02775 NC_009567.1 509625 510809 D catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 509625..510809 Haemophilus influenzae PittGG 5227058 YP_001291964.1 CDS CGSHiGG_02780 NC_009567.1 510862 511575 R COG0861 Membrane protein TerC, possibly involved in tellurium resistance; mannonate dehydratase complement(510862..511575) Haemophilus influenzae PittGG 5227059 YP_001291965.1 CDS CGSHiGG_02800 NC_009567.1 513645 514409 R CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase complement(513645..514409) Haemophilus influenzae PittGG 5227060 YP_001291966.1 CDS lpxK NC_009567.1 514480 515382 R COG1663 Tetraacyldisaccharide-1-P 4'-kinase; tetraacyldisaccharide 4'-kinase complement(514480..515382) Haemophilus influenzae PittGG 5227061 YP_001291967.1 CDS CGSHiGG_02810 NC_009567.1 515551 517314 R involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease protein complement(515551..517314) Haemophilus influenzae PittGG 5227062 YP_001291968.1 CDS CGSHiGG_02825 NC_009567.1 519981 520418 D COG1734 DnaK suppressor protein; DnaK suppressor protein 519981..520418 Haemophilus influenzae PittGG 5227063 YP_001291969.1 CDS CGSHiGG_02830 NC_009567.1 520666 522024 D COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; polyA polymerase 520666..522024 Haemophilus influenzae PittGG 5227064 YP_001291970.1 CDS CGSHiGG_02835 NC_009567.1 522033 522515 D COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 522033..522515 Haemophilus influenzae PittGG 5227065 YP_001291971.1 CDS CGSHiGG_02840 NC_009567.1 522630 523067 D COG0802 Predicted ATPase or kinase; hypothetical protein 522630..523067 Haemophilus influenzae PittGG 5227066 YP_001291972.1 CDS CGSHiGG_02845 NC_009567.1 523075 524373 D COG0860 N-acetylmuramoyl-L-alanine amidase; lipid ABC transporter membrane protein/ATP-binding protein 523075..524373 Haemophilus influenzae PittGG 5227067 YP_001291973.1 CDS mutL NC_009567.1 524374 526263 D This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 524374..526263 Haemophilus influenzae PittGG 5227068 YP_001291974.1 CDS CGSHiGG_02865 NC_009567.1 527211 530156 D catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 527211..530156 Haemophilus influenzae PittGG 5227069 YP_001291975.1 CDS ppnK NC_009567.1 532031 532921 R catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase complement(532031..532921) Haemophilus influenzae PittGG 5227070 YP_001291976.1 CDS CGSHiGG_02890 NC_009567.1 532913 533617 D with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 532913..533617 Haemophilus influenzae PittGG 5227071 YP_001291977.1 CDS CGSHiGG_02895 NC_009567.1 533630 533974 R nucleotidyltransferase complement(533630..533974) Haemophilus influenzae PittGG 5227072 YP_001291978.1 CDS ppnK NC_009567.1 533976 534404 R COG1708 Predicted nucleotidyltransferases; inorganic polyphosphate/ATP-NAD kinase complement(533976..534404) Haemophilus influenzae PittGG 5227073 YP_001291979.1 CDS CGSHiGG_02910 NC_009567.1 535224 535319 D COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; hypothetical protein 535224..535319 Haemophilus influenzae PittGG 5227074 YP_001291980.1 CDS CGSHiGG_02920 NC_009567.1 536931 537791 D anaerobic ribonucleoside triphosphate reductase 536931..537791 Haemophilus influenzae PittGG 5227075 YP_001291981.1 CDS CGSHiGG_02925 NC_009567.1 537800 537874 D COG1946 Acyl-CoA thioesterase; hypothetical protein 537800..537874 Haemophilus influenzae PittGG 5227076 YP_001291982.1 CDS cysS NC_009567.1 537950 539329 R catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase complement(537950..539329) Haemophilus influenzae PittGG 5227077 YP_001291983.1 CDS CGSHiGG_02935 NC_009567.1 539432 539941 D COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; peptidyl-prolyl cis-trans isomerase B 539432..539941 Haemophilus influenzae PittGG 5227078 YP_001291984.1 CDS CGSHiGG_02950 NC_009567.1 540894 540992 D COG0084 Mg-dependent DNase; hypothetical protein 540894..540992 Haemophilus influenzae PittGG 5227079 YP_001291985.1 CDS CGSHiGG_02955 NC_009567.1 541040 541306 D hypothetical protein 541040..541306 Haemophilus influenzae PittGG 5227080 YP_001291986.1 CDS CGSHiGG_02960 NC_009567.1 541282 541590 D COG1960 Acyl-CoA dehydrogenases; hypothetical protein 541282..541590 Haemophilus influenzae PittGG 5227081 YP_001291987.1 CDS CGSHiGG_02965 NC_009567.1 541587 541910 R COG0526 Thiol-disulfide isomerase and thioredoxins; thioredoxin complement(541587..541910) Haemophilus influenzae PittGG 5227082 YP_001291988.1 CDS cysS NC_009567.1 542029 543024 R COG1052 Lactate dehydrogenase and related dehydrogenases; cysteinyl-tRNA synthetase complement(542029..543024) Haemophilus influenzae PittGG 5227083 YP_001291989.1 CDS CGSHiGG_02985 NC_009567.1 545011 546288 R catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase complement(545011..546288) Haemophilus influenzae PittGG 5227084 YP_001291990.1 CDS CGSHiGG_02990 NC_009567.1 546331 547275 R catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase complement(546331..547275) Haemophilus influenzae PittGG 5227085 YP_001291991.1 CDS CGSHiGG_03005 NC_009567.1 549829 549915 R COG0527 Aspartokinases; hypothetical protein complement(549829..549915) Haemophilus influenzae PittGG 5227086 YP_001291992.1 CDS CGSHiGG_03010 NC_009567.1 550060 550761 D COG0325 Predicted enzyme with a TIM-barrel fold; hypothetical protein 550060..550761 Haemophilus influenzae PittGG 5227087 YP_001291993.1 CDS CGSHiGG_03015 NC_009567.1 550834 551589 R hypothetical protein complement(550834..551589) Haemophilus influenzae PittGG 5227088 YP_001291994.1 CDS CGSHiGG_03025 NC_009567.1 552223 553221 D COG1840 ABC-type Fe3+ transport system, periplasmic component; iron-utilization periplasmic protein FbpA 552223..553221 Haemophilus influenzae PittGG 5227095 YP_001291995.1 CDS thrA NC_009567.1 555951 556631 R COG1876 D-alanyl-D-alanine carboxypeptidase; bifunctional aspartokinase I/homoserine dehydrogenase I complement(555951..556631) Haemophilus influenzae PittGG 5227097 YP_001291996.1 CDS CGSHiGG_03055 NC_009567.1 556633 557766 R dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase complement(556633..557766) Haemophilus influenzae PittGG 5227098 YP_001291997.1 CDS CGSHiGG_03060 NC_009567.1 557794 558138 R COG1393 Arsenate reductase and related proteins, glutaredoxin family; succinyl-diaminopimelate desuccinylase complement(557794..558138) Haemophilus influenzae PittGG 5227099 YP_001291998.1 CDS CGSHiGG_03065 NC_009567.1 558217 560097 R molecular chaperone; heat shock protein 90 complement(558217..560097) Haemophilus influenzae PittGG 5227100 YP_001291999.1 CDS CGSHiGG_03080 NC_009567.1 561338 563710 D COG0286 Type I restriction-modification system methyltransferase subunit; putative type I restriction-modification system, methyltransferase subunit 561338..563710 Haemophilus influenzae PittGG 5227101 YP_001292000.1 CDS CGSHiGG_03085 NC_009567.1 563899 565173 D COG0732 Restriction endonuclease S subunits; type I restriction modification DNA specificity domain-containing protein 563899..565173 Haemophilus influenzae PittGG 5227102 YP_001292001.1 CDS CGSHiGG_03090 NC_009567.1 565268 568288 D COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases; putative type I site-specific restriction-modification system, R subunit 565268..568288 Haemophilus influenzae PittGG 5227103 YP_001292002.1 CDS CGSHiGG_03095 NC_009567.1 568513 569901 R COG0541 Signal recognition particle GTPase; Signal recognition particle protein complement(568513..569901) Haemophilus influenzae PittGG 5227104 YP_001292003.1 CDS CGSHiGG_03100 NC_009567.1 570182 571444 D putative Mg2+ and Co2+ transporter 570182..571444 Haemophilus influenzae PittGG 5227105 YP_001292004.1 CDS CGSHiGG_03105 NC_009567.1 571441 571515 R COG4536 Putative Mg2+ and Co2+ transporter CorB; hypothetical protein complement(571441..571515) Haemophilus influenzae PittGG 5227106 YP_001292005.1 CDS CGSHiGG_03110 NC_009567.1 571573 572343 D COG2966 Uncharacterized conserved protein; hypothetical protein 571573..572343 Haemophilus influenzae PittGG 5227107 YP_001292006.1 CDS CGSHiGG_03115 NC_009567.1 572345 572824 D hypothetical protein 572345..572824 Haemophilus influenzae PittGG 5227108 YP_001292007.1 CDS CGSHiGG_03120 NC_009567.1 572997 573254 R COG3610 Uncharacterized conserved protein; heat shock protein 90 complement(572997..573254) Haemophilus influenzae PittGG 5227109 YP_001292008.1 CDS CGSHiGG_03125 NC_009567.1 573421 574710 D catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 573421..574710 Haemophilus influenzae PittGG 5227110 YP_001292009.1 CDS CGSHiGG_03130 NC_009567.1 575045 575674 D COG0625 Glutathione S-transferase; glutathione S-transferase 575045..575674 Haemophilus influenzae PittGG 5227111 YP_001292010.1 CDS CGSHiGG_03135 NC_009567.1 575686 575982 R COG2963 Transposase and inactivated derivatives; hypothetical protein complement(575686..575982) Haemophilus influenzae PittGG 5227112 YP_001292011.1 CDS rlmL NC_009567.1 585341 587476 R catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase complement(585341..587476) Haemophilus influenzae PittGG 5227115 YP_001292012.1 CDS mltA NC_009567.1 587871 588980 D membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A 587871..588980 Haemophilus influenzae PittGG 5227116 YP_001292013.1 CDS mltA NC_009567.1 588965 589750 D COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1; murein transglycosylase A 588965..589750 Haemophilus influenzae PittGG 5227117 YP_001292014.1 CDS znuA NC_009567.1 589929 591032 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic component 589929..591032 Haemophilus influenzae PittGG 5227118 YP_001292015.1 CDS CGSHiGG_03180 NC_009567.1 591082 591588 R COG5413 Uncharacterized integral membrane protein; hypothetical protein complement(591082..591588) Haemophilus influenzae PittGG 5227119 YP_001292016.1 CDS znuA NC_009567.1 591701 593062 R high-affinity zinc transporter periplasmic component complement(591701..593062) Haemophilus influenzae PittGG 5227120 YP_001292017.1 CDS CGSHiGG_03190 NC_009567.1 593372 593491 D COG0773 UDP-N-acetylmuramate-alanine ligase; hypothetical protein 593372..593491 Haemophilus influenzae PittGG 5227121 YP_001292018.1 CDS CGSHiGG_03195 NC_009567.1 593540 594727 R catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase complement(593540..594727) Haemophilus influenzae PittGG 5227122 YP_001292019.1 CDS CGSHiGG_03200 NC_009567.1 594864 595466 D COG0450 Peroxiredoxin; peroxiredoxin 594864..595466 Haemophilus influenzae PittGG 5227123 YP_001292020.1 CDS CGSHiGG_03205 NC_009567.1 595567 596112 D CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 595567..596112 Haemophilus influenzae PittGG 5227124 YP_001292022.1 CDS CGSHiGG_03215 NC_009567.1 596694 597224 R COG0221 Inorganic pyrophosphatase; inorganic pyrophosphatase complement(596694..597224) Haemophilus influenzae PittGG 5227126 YP_001292023.1 CDS CGSHiGG_03220 NC_009567.1 597458 598774 D COG2252 Permeases; cystathionine beta-lyase 597458..598774 Haemophilus influenzae PittGG 5227127 YP_001292024.1 CDS fbpC NC_009567.1 598863 599912 R Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import; ferric transporter ATP-binding subunit complement(598863..599912) Haemophilus influenzae PittGG 5227128 YP_001292025.1 CDS CGSHiGG_03230 NC_009567.1 599937 601994 R COG1178 ABC-type Fe3+ transport system, permease component; ferric transport system permease protein FbpB complement(599937..601994) Haemophilus influenzae PittGG 5227129 YP_001292026.1 CDS fbpC NC_009567.1 602156 603196 R COG1840 ABC-type Fe3+ transport system, periplasmic component; ferric transporter ATP-binding subunit complement(602156..603196) Haemophilus influenzae PittGG 5227130 YP_001292027.1 CDS CGSHiGG_03240 NC_009567.1 603362 604003 D functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 603362..604003 Haemophilus influenzae PittGG 5227131 YP_001292028.1 CDS dcd NC_009567.1 604012 604599 D Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 604012..604599 Haemophilus influenzae PittGG 5227132 YP_001292029.1 CDS CGSHiGG_03255 NC_009567.1 605778 606968 D COG2814 Arabinose efflux permease; sugar efflux transporter 605778..606968 Haemophilus influenzae PittGG 5227136 YP_001292030.1 CDS engA NC_009567.1 607047 608561 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(607047..608561) Haemophilus influenzae PittGG 5227137 YP_001292031.1 CDS CGSHiGG_03265 NC_009567.1 609241 610011 R 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon complement(609241..610011) Haemophilus influenzae PittGG 5227138 YP_001292032.1 CDS rnhA NC_009567.1 610072 610536 D An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 610072..610536 Haemophilus influenzae PittGG 5227139 YP_001292033.1 CDS CGSHiGG_03275 NC_009567.1 610814 611953 D COG3203 Outer membrane protein (porin); Outer membrane protein P2 610814..611953 Haemophilus influenzae PittGG 5227140 YP_001292034.1 CDS nagA NC_009567.1 612187 613335 R catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase complement(612187..613335) Haemophilus influenzae PittGG 5227141 YP_001292035.1 CDS CGSHiGG_03295 NC_009567.1 614300 614455 R COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase; hypothetical protein complement(614300..614455) Haemophilus influenzae PittGG 5227142 YP_001292036.1 CDS CGSHiGG_03300 NC_009567.1 614598 615479 R catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase complement(614598..615479) Haemophilus influenzae PittGG 5227143 YP_001292037.1 CDS CGSHiGG_03305 NC_009567.1 615490 616356 R COG1737 Transcriptional regulators; hypothetical protein complement(615490..616356) Haemophilus influenzae PittGG 5227144 YP_001292038.1 CDS CGSHiGG_03310 NC_009567.1 616349 617251 R catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase complement(616349..617251) Haemophilus influenzae PittGG 5227145 YP_001292039.1 CDS CGSHiGG_03315 NC_009567.1 617296 617982 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(617296..617982) Haemophilus influenzae PittGG 5227146 YP_001292040.1 CDS CGSHiGG_03320 NC_009567.1 618333 619319 D COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component; hypothetical protein 618333..619319 Haemophilus influenzae PittGG 5227147 YP_001292041.1 CDS CGSHiGG_03325 NC_009567.1 619384 621234 D COG3090 TRAP-type C4-dicarboxylate transport system, small permease component; hypothetical protein 619384..621234 Haemophilus influenzae PittGG 5227148 YP_001292042.1 CDS CGSHiGG_03330 NC_009567.1 621410 622537 D COG3055 Uncharacterized protein conserved in bacteria; N-acetylneuraminic acid mutarotase 621410..622537 Haemophilus influenzae PittGG 5227149 YP_001292043.1 CDS CGSHiGG_03335 NC_009567.1 622699 623130 D COG2020 Putative protein-S-isoprenylcysteine methyltransferase; putative protein-S-isoprenylcysteine methyltransferase 622699..623130 Haemophilus influenzae PittGG 5227150 YP_001292044.1 CDS CGSHiGG_03340 NC_009567.1 623174 624061 R COG0330 Membrane protease subunits, stomatin/prohibitin homologs; hypothetical protein complement(623174..624061) Haemophilus influenzae PittGG 5227151 YP_001292045.1 CDS CGSHiGG_03345 NC_009567.1 624061 625281 R FtsH protease regulator HflK complement(624061..625281) Haemophilus influenzae PittGG 5227152 YP_001292046.1 CDS CGSHiGG_03360 NC_009567.1 626171 627502 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter complement(626171..627502) Haemophilus influenzae PittGG 5227153 YP_001292047.1 CDS acpP NC_009567.1 627707 627937 R carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein complement(627707..627937) Haemophilus influenzae PittGG 5227154 YP_001292048.1 CDS fabG NC_009567.1 628193 628921 R catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase complement(628193..628921) Haemophilus influenzae PittGG 5227155 YP_001292049.1 CDS CGSHiGG_03375 NC_009567.1 628938 629876 R COG0331 (acyl-carrier-protein) S-malonyltransferase; acyl carrier protein S-malonyltransferase complement(628938..629876) Haemophilus influenzae PittGG 5227156 YP_001292050.1 CDS CGSHiGG_03380 NC_009567.1 630502 631452 R FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III complement(630502..631452) Haemophilus influenzae PittGG 5227157 YP_001292051.1 CDS CGSHiGG_03385 NC_009567.1 631487 631588 R COG0332 3-oxoacyl-[acyl-carrier-protein] synthase III; hypothetical protein complement(631487..631588) Haemophilus influenzae PittGG 5227158 YP_001292052.1 CDS rpmF NC_009567.1 631638 631808 R some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 complement(631638..631808) Haemophilus influenzae PittGG 5227159 YP_001292053.1 CDS CGSHiGG_03395 NC_009567.1 631851 632354 R COG1399 Predicted metal-binding, possibly nucleic acid-binding protein; hypothetical protein complement(631851..632354) Haemophilus influenzae PittGG 5227160 YP_001292054.1 CDS CGSHiGG_03410 NC_009567.1 633492 634862 R catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase complement(633492..634862) Haemophilus influenzae PittGG 5227161 YP_001292055.1 CDS CGSHiGG_03415 NC_009567.1 635079 635678 R COG3056 Uncharacterized lipoprotein; lipoprotein complement(635079..635678) Haemophilus influenzae PittGG 5227162 YP_001292056.1 CDS CGSHiGG_03420 NC_009567.1 635772 636083 D COG0271 Stress-induced morphogen (activity unknown); transcriptional regulator 635772..636083 Haemophilus influenzae PittGG 5227163 YP_001292057.1 CDS CGSHiGG_03425 NC_009567.1 636375 637718 D uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit A 636375..637718 Haemophilus influenzae PittGG 5227164 YP_001292058.1 CDS CGSHiGG_03430 NC_009567.1 637721 638956 D uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit B 637721..638956 Haemophilus influenzae PittGG 5227165 YP_001292059.1 CDS CGSHiGG_03435 NC_009567.1 638949 639683 D uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit C 638949..639683 Haemophilus influenzae PittGG 5227166 YP_001292060.1 CDS CGSHiGG_03440 NC_009567.1 639683 640309 D Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit D 639683..640309 Haemophilus influenzae PittGG 5227167 YP_001292061.1 CDS CGSHiGG_03445 NC_009567.1 640313 640909 D Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.; Na(+)-translocating NADH-quinone reductase subunit E 640313..640909 Haemophilus influenzae PittGG 5227168 YP_001292062.1 CDS CGSHiGG_03450 NC_009567.1 640922 642157 D uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit F 640922..642157 Haemophilus influenzae PittGG 5227169 YP_001292063.1 CDS CGSHiGG_03455 NC_009567.1 642301 643341 D COG1477 Membrane-associated lipoprotein involved in thiamine biosynthesis; thiamine biosynthesis lipoprotein ApbE 642301..643341 Haemophilus influenzae PittGG 5227170 YP_001292064.1 CDS CGSHiGG_03460 NC_009567.1 643344 643604 D COG2991 Uncharacterized protein conserved in bacteria; hypothetical protein 643344..643604 Haemophilus influenzae PittGG 5227171 YP_001292065.1 CDS mnmA NC_009567.1 643721 644878 D catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 643721..644878 Haemophilus influenzae PittGG 5227172 YP_001292066.1 CDS CGSHiGG_03470 NC_009567.1 644922 645656 R COG1496 Uncharacterized conserved protein; hypothetical protein complement(644922..645656) Haemophilus influenzae PittGG 5227173 YP_001292067.1 CDS rluD NC_009567.1 645658 646632 R responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D complement(645658..646632) Haemophilus influenzae PittGG 5227174 YP_001292068.1 CDS CGSHiGG_03480 NC_009567.1 646740 647528 D COG4105 DNA uptake lipoprotein; hypothetical protein 646740..647528 Haemophilus influenzae PittGG 5227175 YP_001292069.1 CDS CGSHiGG_03485 NC_009567.1 647608 647952 R COG0525 Valyl-tRNA synthetase; hypothetical protein complement(647608..647952) Haemophilus influenzae PittGG 5227176 YP_001292070.1 CDS pflA NC_009567.1 648121 648861 R activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 complement(648121..648861) Haemophilus influenzae PittGG 5227177 YP_001292071.1 CDS CGSHiGG_03495 NC_009567.1 649014 651230 R COG1882 Pyruvate-formate lyase; formate acetyltransferase complement(649014..651230) Haemophilus influenzae PittGG 5227178 YP_001292072.1 CDS CGSHiGG_03500 NC_009567.1 651193 651303 R COG1882 Pyruvate-formate lyase; formate acetyltransferase complement(651193..651303) Haemophilus influenzae PittGG 5227179 YP_001292073.1 CDS CGSHiGG_03505 NC_009567.1 651341 652195 R COG2116 Formate/nitrite family of transporters; putative formate transporter complement(651341..652195) Haemophilus influenzae PittGG 5227180 YP_001292074.1 CDS CGSHiGG_03510 NC_009567.1 652700 653614 D catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 652700..653614 Haemophilus influenzae PittGG 5227181 YP_001292075.1 CDS CGSHiGG_03515 NC_009567.1 653798 655237 D COG1115 Na+/alanine symporter; amino acid carrier protein 653798..655237 Haemophilus influenzae PittGG 5227182 YP_001292076.1 CDS CGSHiGG_03520 NC_009567.1 655422 656249 R COG0627 Predicted esterase; esterase complement(655422..656249) Haemophilus influenzae PittGG 5227183 YP_001292077.1 CDS CGSHiGG_03525 NC_009567.1 656258 657394 R COG1062 Zn-dependent alcohol dehydrogenases, class III; alcohol dehydrogenase class III complement(656258..657394) Haemophilus influenzae PittGG 5227184 YP_001292078.1 CDS CGSHiGG_03530 NC_009567.1 657517 657924 D COG0789 Predicted transcriptional regulators; putative HTH-type transcriptional regulator 657517..657924 Haemophilus influenzae PittGG 5227185 YP_001292079.1 CDS CGSHiGG_03535 NC_009567.1 658192 658368 D COG1826 Sec-independent protein secretion pathway components; Sec-independent protein translocase protein TatA/E 658192..658368 Haemophilus influenzae PittGG 5227186 YP_001292080.1 CDS CGSHiGG_03540 NC_009567.1 658372 658932 D mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 658372..658932 Haemophilus influenzae PittGG 5227187 YP_001292081.1 CDS CGSHiGG_03545 NC_009567.1 658942 659721 D COG0805 Sec-independent protein secretion pathway component TatC; Sec-independent protein translocase protein TatC 658942..659721 Haemophilus influenzae PittGG 5227188 YP_001292082.1 CDS CGSHiGG_03560 NC_009567.1 661527 661967 R COG0735 Fe2+/Zn2+ uptake regulation proteins; ferric uptake regulation protein complement(661527..661967) Haemophilus influenzae PittGG 5227189 YP_001292083.1 CDS CGSHiGG_03565 NC_009567.1 661996 662520 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA complement(661996..662520) Haemophilus influenzae PittGG 5227190 YP_001292084.1 CDS CGSHiGG_03570 NC_009567.1 662617 663399 R COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); esterase/lipase complement(662617..663399) Haemophilus influenzae PittGG 5227191 YP_001292085.1 CDS CGSHiGG_03575 NC_009567.1 663470 664063 D negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 663470..664063 Haemophilus influenzae PittGG 5227192 YP_001292086.1 CDS CGSHiGG_03580 NC_009567.1 664066 665424 D COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; O-succinylbenzoic acid--CoA ligase 664066..665424 Haemophilus influenzae PittGG 5227193 YP_001292087.1 CDS CGSHiGG_03585 NC_009567.1 665466 668786 D small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 665466..668786 Haemophilus influenzae PittGG 5227194 YP_001292088.1 CDS CGSHiGG_03590 NC_009567.1 668796 669869 D catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 668796..669869 Haemophilus influenzae PittGG 5227195 YP_001292089.1 CDS mepA NC_009567.1 670042 670902 D D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 670042..670902 Haemophilus influenzae PittGG 5227196 YP_001292090.1 CDS CGSHiGG_03610 NC_009567.1 671735 672691 D Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 671735..672691 Haemophilus influenzae PittGG 5227197 YP_001292091.1 CDS CGSHiGG_03615 NC_009567.1 672818 673789 D catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 672818..673789 Haemophilus influenzae PittGG 5227198 YP_001292092.1 CDS rplS NC_009567.1 673902 674252 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(673902..674252) Haemophilus influenzae PittGG 5227199 YP_001292093.1 CDS trmD NC_009567.1 674289 675029 R methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase complement(674289..675029) Haemophilus influenzae PittGG 5227200 YP_001292094.1 CDS rimM NC_009567.1 675067 675594 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(675067..675594) Haemophilus influenzae PittGG 5227201 YP_001292095.1 CDS rpsP NC_009567.1 675639 675887 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(675639..675887) Haemophilus influenzae PittGG 5227202 YP_001292096.1 CDS CGSHiGG_03640 NC_009567.1 676180 676953 D COG0228 Ribosomal protein S16; hypothetical protein 676180..676953 Haemophilus influenzae PittGG 5227203 YP_001292097.1 CDS CGSHiGG_03645 NC_009567.1 676976 678787 D COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; NAD nucleotidase 676976..678787 Haemophilus influenzae PittGG 5227204 YP_001292098.1 CDS aroK NC_009567.1 679072 679614 D catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 679072..679614 Haemophilus influenzae PittGG 5227205 YP_001292099.1 CDS aroB NC_009567.1 679634 680722 D catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 679634..680722 Haemophilus influenzae PittGG 5227206 YP_001292100.1 CDS CGSHiGG_03660 NC_009567.1 680724 681584 D DNA adenine methylase 680724..681584 Haemophilus influenzae PittGG 5227207 YP_001292101.1 CDS CGSHiGG_03665 NC_009567.1 682518 682625 D COG0338 Site-specific DNA methylase; hypothetical protein 682518..682625 Haemophilus influenzae PittGG 5227208 YP_001292102.1 CDS CGSHiGG_03670 NC_009567.1 682644 683369 R COG0671 Membrane-associated phospholipid phosphatase; phosphatidylglycerophosphatase B complement(682644..683369) Haemophilus influenzae PittGG 5227209 YP_001292103.1 CDS ribA NC_009567.1 683438 684088 D catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 683438..684088 Haemophilus influenzae PittGG 5227210 YP_001292104.1 CDS CGSHiGG_03680 NC_009567.1 684411 685955 R COG4166 ABC-type oligopeptide transport system, periplasmic component; oligopeptide transporter periplasmic-binding protein complement(684411..685955) Haemophilus influenzae PittGG 5227211 YP_001292105.1 CDS CGSHiGG_03685 NC_009567.1 685948 686310 R COG2832 Uncharacterized protein conserved in bacteria; hypothetical protein complement(685948..686310) Haemophilus influenzae PittGG 5227212 YP_001292106.1 CDS CGSHiGG_03690 NC_009567.1 686436 688475 D COG0339 Zn-dependent oligopeptidases; oligopeptidase A 686436..688475 Haemophilus influenzae PittGG 5227213 YP_001292107.1 CDS CGSHiGG_03695 NC_009567.1 688707 690251 D COG0286 Type I restriction-modification system methyltransferase subunit; putative type I restriction-modification system methyltransferase subunit 688707..690251 Haemophilus influenzae PittGG 5227214 YP_001292108.1 CDS CGSHiGG_03700 NC_009567.1 690386 691558 D COG0732 Restriction endonuclease S subunits; putative type I restriction-modification system, specificity determinant; restriction endonuclease 690386..691558 Haemophilus influenzae PittGG 5227215 YP_001292109.1 CDS CGSHiGG_03705 NC_009567.1 691724 692254 D COG1943 Transposase and inactivated derivatives; hypothetical protein 691724..692254 Haemophilus influenzae PittGG 5227216 YP_001292110.1 CDS CGSHiGG_03710 NC_009567.1 692359 695442 D COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases; putative type I restriction-modification system 692359..695442 Haemophilus influenzae PittGG 5227217 YP_001292111.1 CDS CGSHiGG_03715 NC_009567.1 695590 696219 R COG3059 Predicted membrane protein; hypothetical protein complement(695590..696219) Haemophilus influenzae PittGG 5227218 YP_001292112.1 CDS CGSHiGG_03720 NC_009567.1 696432 698228 R COG0642 Signal transduction histidine kinase; aerobic respiration control sensor protein ArcB complement(696432..698228) Haemophilus influenzae PittGG 5227219 YP_001292113.1 CDS CGSHiGG_03725 NC_009567.1 698341 698928 R COG1573 Uracil-DNA glycosylase; uracil-DNA glycosylase complement(698341..698928) Haemophilus influenzae PittGG 5227220 YP_001292114.1 CDS CGSHiGG_03730 NC_009567.1 705038 705943 R catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase complement(705038..705943) Haemophilus influenzae PittGG 5227223 YP_001292115.1 CDS CGSHiGG_03735 NC_009567.1 706073 707539 D catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 706073..707539 Haemophilus influenzae PittGG 5227224 YP_001292116.1 CDS guaA NC_009567.1 707649 709220 D contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 707649..709220 Haemophilus influenzae PittGG 5227225 YP_001292117.1 CDS CGSHiGG_03745 NC_009567.1 709282 710172 R COG2962 Predicted permeases; hypothetical protein complement(709282..710172) Haemophilus influenzae PittGG 5227226 YP_001292118.1 CDS CGSHiGG_03750 NC_009567.1 710292 710753 D COG1522 Transcriptional regulators; putative transcriptional regulator 710292..710753 Haemophilus influenzae PittGG 5227227 YP_001292119.1 CDS CGSHiGG_03755 NC_009567.1 710792 711994 R exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter complement(710792..711994) Haemophilus influenzae PittGG 5227228 YP_001292120.1 CDS CGSHiGG_03760 NC_009567.1 712150 713493 D COG1114 Branched-chain amino acid permeases; branched-chain amino acid transport system II carrier protein 712150..713493 Haemophilus influenzae PittGG 5227229 YP_001292121.1 CDS CGSHiGG_03765 NC_009567.1 713601 714068 R hypothetical protein complement(713601..714068) Haemophilus influenzae PittGG 5227230 YP_001292122.1 CDS CGSHiGG_03770 NC_009567.1 714144 714515 R COG2731 Beta-galactosidase, beta subunit; hypothetical protein complement(714144..714515) Haemophilus influenzae PittGG 5227231 YP_001292123.1 CDS CGSHiGG_03775 NC_009567.1 714826 716955 D polynucleotide phosphorylase/polyadenylase 714826..716955 Haemophilus influenzae PittGG 5227232 YP_001292124.1 CDS CGSHiGG_03790 NC_009567.1 718101 719942 D COG0513 Superfamily II DNA and RNA helicases; ATP-dependent RNA helicase 718101..719942 Haemophilus influenzae PittGG 5227233 YP_001292125.1 CDS CGSHiGG_03795 NC_009567.1 720061 721509 D YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; putative transglycosylase 720061..721509 Haemophilus influenzae PittGG 5227234 YP_001292126.1 CDS CGSHiGG_03800 NC_009567.1 721514 721666 D hypothetical protein 721514..721666 Haemophilus influenzae PittGG 5227235 YP_001292127.1 CDS CGSHiGG_03805 NC_009567.1 721801 722097 R COG4623 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein; hypothetical protein complement(721801..722097) Haemophilus influenzae PittGG 5227236 YP_001292128.1 CDS CGSHiGG_03810 NC_009567.1 722116 722361 R COG3036 Uncharacterized protein conserved in bacteria; hypothetical protein complement(722116..722361) Haemophilus influenzae PittGG 5227237 YP_001292129.1 CDS CGSHiGG_03815 NC_009567.1 722429 722779 R COG1393 Arsenate reductase and related proteins, glutaredoxin family; arsenate reductase complement(722429..722779) Haemophilus influenzae PittGG 5227238 YP_001292130.1 CDS CGSHiGG_03820 NC_009567.1 722857 723906 D COG0628 Predicted permease; hypothetical protein 722857..723906 Haemophilus influenzae PittGG 5227239 YP_001292131.1 CDS secF NC_009567.1 724020 724994 R forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF complement(724020..724994) Haemophilus influenzae PittGG 5227240 YP_001292132.1 CDS secD NC_009567.1 725005 726855 R part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD complement(725005..726855) Haemophilus influenzae PittGG 5227241 YP_001292133.1 CDS yajC NC_009567.1 726925 727218 R member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC complement(726925..727218) Haemophilus influenzae PittGG 5227242 YP_001292134.1 CDS CGSHiGG_03840 NC_009567.1 727326 727547 R COG0425 Predicted redox protein, regulator of disulfide bond formation; hypothetical protein complement(727326..727547) Haemophilus influenzae PittGG 5227243 YP_001292135.1 CDS CGSHiGG_03845 NC_009567.1 727544 728062 R COG0457 FOG: TPR repeat; hypothetical protein complement(727544..728062) Haemophilus influenzae PittGG 5227244 YP_001292136.1 CDS tgt NC_009567.1 728127 729275 R Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase complement(728127..729275) Haemophilus influenzae PittGG 5227245 YP_001292137.1 CDS queA NC_009567.1 729618 730709 R Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase complement(729618..730709) Haemophilus influenzae PittGG 5227246 YP_001292138.1 CDS CGSHiGG_03860 NC_009567.1 730833 731279 R COG0809 S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase); hypothetical protein complement(730833..731279) Haemophilus influenzae PittGG 5227247 YP_001292139.1 CDS uvrA NC_009567.1 735942 738773 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A complement(735942..738773) Haemophilus influenzae PittGG 5227248 YP_001292140.1 CDS CGSHiGG_03885 NC_009567.1 738927 739433 D binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 738927..739433 Haemophilus influenzae PittGG 5227249 YP_001292141.1 CDS CGSHiGG_03890 NC_009567.1 739581 740813 D COG0582 Integrase; hypothetical protein 739581..740813 Haemophilus influenzae PittGG 5227250 YP_001292142.1 CDS CGSHiGG_03915 NC_009567.1 744414 744824 D COG4688 Uncharacterized protein conserved in bacteria; hypothetical protein 744414..744824 Haemophilus influenzae PittGG 5227251 YP_001292143.1 CDS CGSHiGG_03920 NC_009567.1 745198 746280 R COG3621 Patatin; patatin complement(745198..746280) Haemophilus influenzae PittGG 5227252 YP_001292144.1 CDS CGSHiGG_03925 NC_009567.1 746264 747103 R COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1; hypothetical protein complement(746264..747103) Haemophilus influenzae PittGG 5227253 YP_001292145.1 CDS CGSHiGG_03930 NC_009567.1 747141 747989 R hypothetical protein complement(747141..747989) Haemophilus influenzae PittGG 5227254 YP_001292146.1 CDS CGSHiGG_03935 NC_009567.1 747973 748326 R hypothetical protein complement(747973..748326) Haemophilus influenzae PittGG 5227255 YP_001292147.1 CDS CGSHiGG_03950 NC_009567.1 750612 751406 R COG0810 Periplasmic protein TonB, links inner and outer membranes; TonB complement(750612..751406) Haemophilus influenzae PittGG 5227256 YP_001292148.1 CDS CGSHiGG_03955 NC_009567.1 751416 751859 R COG0848 Biopolymer transport protein; biopolymer transport protein complement(751416..751859) Haemophilus influenzae PittGG 5227257 YP_001292149.1 CDS CGSHiGG_03960 NC_009567.1 751863 752315 R COG0811 Biopolymer transport proteins; transport protein ExbB complement(751863..752315) Haemophilus influenzae PittGG 5227258 YP_001292150.1 CDS bcp NC_009567.1 752484 752951 R bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase complement(752484..752951) Haemophilus influenzae PittGG 5227259 YP_001292151.1 CDS CGSHiGG_03970 NC_009567.1 753052 753948 D catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 753052..753948 Haemophilus influenzae PittGG 5227260 YP_001292152.1 CDS CGSHiGG_03975 NC_009567.1 754059 754706 D COG3317 Uncharacterized lipoprotein; lipoprotein 754059..754706 Haemophilus influenzae PittGG 5227261 YP_001292153.1 CDS CGSHiGG_03980 NC_009567.1 754879 755202 D COG1544 Ribosome-associated protein Y (PSrp-1); hypothetical protein 754879..755202 Haemophilus influenzae PittGG 5227262 YP_001292154.1 CDS CGSHiGG_03985 NC_009567.1 755803 756093 R COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system; hypothetical protein complement(755803..756093) Haemophilus influenzae PittGG 5227263 YP_001292155.1 CDS CGSHiGG_03990 NC_009567.1 756083 756337 R COG2161 Antitoxin of toxin-antitoxin stability system; hypothetical protein complement(756083..756337) Haemophilus influenzae PittGG 5227264 YP_001292156.1 CDS CGSHiGG_03995 NC_009567.1 756833 759040 R hypothetical protein complement(756833..759040) Haemophilus influenzae PittGG 5227265 YP_001292157.1 CDS CGSHiGG_04000 NC_009567.1 759050 759328 R hypothetical protein complement(759050..759328) Haemophilus influenzae PittGG 5227266 YP_001292158.1 CDS CGSHiGG_04005 NC_009567.1 759337 759561 R hypothetical protein complement(759337..759561) Haemophilus influenzae PittGG 5227267 YP_001292159.1 CDS CGSHiGG_04010 NC_009567.1 759558 760382 R hypothetical protein complement(759558..760382) Haemophilus influenzae PittGG 5227268 YP_001292160.1 CDS CGSHiGG_04015 NC_009567.1 760442 760672 R COG5519 Superfamily II helicase and inactivated derivatives; hypothetical protein complement(760442..760672) Haemophilus influenzae PittGG 5227269 YP_001292161.1 CDS CGSHiGG_04020 NC_009567.1 760653 760868 R hypothetical protein complement(760653..760868) Haemophilus influenzae PittGG 5227270 YP_001292162.1 CDS CGSHiGG_04025 NC_009567.1 760936 761100 R hypothetical protein complement(760936..761100) Haemophilus influenzae PittGG 5227271 YP_001292163.1 CDS CGSHiGG_04040 NC_009567.1 762573 762998 R COG0553 Superfamily II DNA/RNA helicases, SNF2 family; hypothetical protein complement(762573..762998) Haemophilus influenzae PittGG 5227272 YP_001292164.1 CDS CGSHiGG_04045 NC_009567.1 762973 763617 R COG1196 Chromosome segregation ATPases; hypothetical protein complement(762973..763617) Haemophilus influenzae PittGG 5227273 YP_001292165.1 CDS CGSHiGG_04050 NC_009567.1 763951 764496 R COG1196 Chromosome segregation ATPases; hypothetical protein complement(763951..764496) Haemophilus influenzae PittGG 5227274 YP_001292166.1 CDS CGSHiGG_04055 NC_009567.1 764498 764713 R transcriptional regulator complement(764498..764713) Haemophilus influenzae PittGG 5227275 YP_001292167.1 CDS CGSHiGG_04060 NC_009567.1 765188 765433 D COG3311 Predicted transcriptional regulator; putative phage gene 765188..765433 Haemophilus influenzae PittGG 5227276 YP_001292168.1 CDS CGSHiGG_04065 NC_009567.1 765439 766458 R COG0582 Integrase; prophage integrase complement(765439..766458) Haemophilus influenzae PittGG 5227277 YP_001292169.1 CDS CGSHiGG_04080 NC_009567.1 768201 768788 R HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase complement(768201..768788) Haemophilus influenzae PittGG 5227278 YP_001292170.1 CDS CGSHiGG_04085 NC_009567.1 768799 769524 R catalyzes the phosphorylation of 3-deoxy-D-manno-octulosonic acid at the 4-OH position; 3-deoxy-D-manno-octulosonic-acid kinase complement(768799..769524) Haemophilus influenzae PittGG 5227279 YP_001292171.1 CDS CGSHiGG_04090 NC_009567.1 769601 770644 D COG0859 ADP-heptose:LPS heptosyltransferase; ADP-heptose--lipooligosaccharide heptosyltransferase I 769601..770644 Haemophilus influenzae PittGG 5227280 YP_001292172.1 CDS CGSHiGG_04095 NC_009567.1 770979 773135 D COG1629 Outer membrane receptor proteins, mostly Fe transport; heme-hemopexin utilization protein C 770979..773135 Haemophilus influenzae PittGG 5227281 YP_001292173.1 CDS CGSHiGG_04100 NC_009567.1 773217 774908 D COG2831 Hemolysin activation/secretion protein; heme/hemopexin-binding protein B 773217..774908 Haemophilus influenzae PittGG 5227282 YP_001292174.1 CDS CGSHiGG_04115 NC_009567.1 777768 778124 R COG1539 Dihydroneopterin aldolase; dihydroneopterin aldolase complement(777768..778124) Haemophilus influenzae PittGG 5227283 YP_001292175.1 CDS CGSHiGG_04120 NC_009567.1 778207 778806 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY 778207..778806 Haemophilus influenzae PittGG 5227284 YP_001292176.1 CDS CGSHiGG_04125 NC_009567.1 778847 780550 D COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific; nitrate/nitrite sensor protein NarQ 778847..780550 Haemophilus influenzae PittGG 5227285 YP_001292177.1 CDS CGSHiGG_04140 NC_009567.1 781710 782555 D binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 781710..782555 Haemophilus influenzae PittGG 5227286 YP_001292178.1 CDS djlA NC_009567.1 783022 783888 R functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein complement(783022..783888) Haemophilus influenzae PittGG 5227287 YP_001292179.1 CDS pyrE NC_009567.1 783955 784596 R involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase complement(783955..784596) Haemophilus influenzae PittGG 5227288 YP_001292180.1 CDS rph NC_009567.1 784620 785336 R RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH complement(784620..785336) Haemophilus influenzae PittGG 5227289 YP_001292181.1 CDS gltX NC_009567.1 785639 787081 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(785639..787081) Haemophilus influenzae PittGG 5227290 YP_001292182.1 CDS CGSHiGG_04175 NC_009567.1 787830 789485 D COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily; hypothetical protein 787830..789485 Haemophilus influenzae PittGG 5227291 YP_001292183.1 CDS rbn NC_009567.1 789505 790314 R RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN complement(789505..790314) Haemophilus influenzae PittGG 5227292 YP_001292184.1 CDS CGSHiGG_04185 NC_009567.1 790311 790793 R COG3012 Uncharacterized protein conserved in bacteria; hypothetical protein complement(790311..790793) Haemophilus influenzae PittGG 5227293 YP_001292185.1 CDS CGSHiGG_04190 NC_009567.1 790893 791459 R COG2258 Uncharacterized protein conserved in bacteria; hypothetical protein complement(790893..791459) Haemophilus influenzae PittGG 5227294 YP_001292186.1 CDS CGSHiGG_04195 NC_009567.1 791695 792453 D catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 791695..792453 Haemophilus influenzae PittGG 5227295 YP_001292187.1 CDS CGSHiGG_04200 NC_009567.1 792679 793995 R COG0477 Permeases of the major facilitator superfamily; transport protein complement(792679..793995) Haemophilus influenzae PittGG 5227296 YP_001292188.1 CDS CGSHiGG_04205 NC_009567.1 794051 794794 R catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase YfbB complement(794051..794794) Haemophilus influenzae PittGG 5227297 YP_001292189.1 CDS CGSHiGG_04210 NC_009567.1 794856 796562 R SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase complement(794856..796562) Haemophilus influenzae PittGG 5227298 YP_001292190.1 CDS CGSHiGG_04215 NC_009567.1 796578 797735 R menaquinone-specific isochorismate synthase complement(796578..797735) Haemophilus influenzae PittGG 5227299 YP_001292191.1 CDS CGSHiGG_04220 NC_009567.1 797783 798052 D COG1169 Isochorismate synthase; hypothetical protein 797783..798052 Haemophilus influenzae PittGG 5227300 YP_001292192.1 CDS CGSHiGG_04225 NC_009567.1 798006 799277 D broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 798006..799277 Haemophilus influenzae PittGG 5227301 YP_001292193.1 CDS CGSHiGG_04230 NC_009567.1 799378 800595 D COG0814 Amino acid permeases; tryptophan-specific transport protein 799378..800595 Haemophilus influenzae PittGG 5227306 YP_001292194.1 CDS CGSHiGG_04250 NC_009567.1 802106 803344 R COG0814 Amino acid permeases; serine transporter complement(802106..803344) Haemophilus influenzae PittGG 5227307 YP_001292195.1 CDS CGSHiGG_04255 NC_009567.1 803567 805735 R COG2217 Cation transport ATPase; putative cation-transporting ATPase complement(803567..805735) Haemophilus influenzae PittGG 5227308 YP_001292196.1 CDS CGSHiGG_04260 NC_009567.1 805710 805916 R COG2608 Copper chaperone; mercuric ion scavenger protein complement(805710..805916) Haemophilus influenzae PittGG 5227309 YP_001292197.1 CDS CGSHiGG_04265 NC_009567.1 806002 806208 R COG2608 Copper chaperone; mercuric ion scavenger protein complement(806002..806208) Haemophilus influenzae PittGG 5227310 YP_001292198.1 CDS CGSHiGG_04270 NC_009567.1 806294 806500 R COG2608 Copper chaperone; mercuric ion scavenger protein complement(806294..806500) Haemophilus influenzae PittGG 5227311 YP_001292199.1 CDS CGSHiGG_04275 NC_009567.1 806574 806780 R COG2608 Copper chaperone; mercuric ion scavenger protein complement(806574..806780) Haemophilus influenzae PittGG 5227312 YP_001292200.1 CDS CGSHiGG_04280 NC_009567.1 806857 807243 D COG0789 Predicted transcriptional regulators; transcriptional regulator MerR family protein 806857..807243 Haemophilus influenzae PittGG 5227313 YP_001292201.1 CDS CGSHiGG_04285 NC_009567.1 807257 807466 R when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ complement(807257..807466) Haemophilus influenzae PittGG 5227314 YP_001292202.1 CDS rho NC_009567.1 807824 809086 D An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 807824..809086 Haemophilus influenzae PittGG 5227315 YP_001292203.1 CDS CGSHiGG_04295 NC_009567.1 809188 809832 R COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases; putative type 4 prepilin-like protein specific leader peptidase complement(809188..809832) Haemophilus influenzae PittGG 5227316 YP_001292204.1 CDS CGSHiGG_04300 NC_009567.1 809829 811049 R COG1459 Type II secretory pathway, component PulF; putative type IV pilin secretion protein complement(809829..811049) Haemophilus influenzae PittGG 5227317 YP_001292205.1 CDS CGSHiGG_04305 NC_009567.1 811046 812440 R COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB; protein transport protein complement(811046..812440) Haemophilus influenzae PittGG 5227318 YP_001292206.1 CDS CGSHiGG_04310 NC_009567.1 812437 812886 R COG4969 Tfp pilus assembly protein, major pilin PilA; prepilin peptidase-dependent protein D complement(812437..812886) Haemophilus influenzae PittGG 5227319 YP_001292207.1 CDS CGSHiGG_04315 NC_009567.1 813001 813564 D COG3023 Negative regulator of beta-lactamase expression; N-acetyl-anhydromuranmyl-L-alanine amidase 813001..813564 Haemophilus influenzae PittGG 5227320 YP_001292208.1 CDS CGSHiGG_04320 NC_009567.1 814186 815085 D COG4535 Putative Mg2+ and Co2+ transporter CorC; magnesium and cobalt efflux protein CorC 814186..815085 Haemophilus influenzae PittGG 5227321 YP_001292209.1 CDS lnt NC_009567.1 815069 816637 D Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 815069..816637 Haemophilus influenzae PittGG 5227322 YP_001292210.1 CDS CGSHiGG_04330 NC_009567.1 816687 817424 D in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 816687..817424 Haemophilus influenzae PittGG 5227323 YP_001292211.1 CDS CGSHiGG_04335 NC_009567.1 817424 817981 D COG1678 Putative transcriptional regulator; hypothetical protein 817424..817981 Haemophilus influenzae PittGG 5227324 YP_001292212.1 CDS CGSHiGG_04340 NC_009567.1 817981 818400 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 817981..818400 Haemophilus influenzae PittGG 5227325 YP_001292213.1 CDS rdgC NC_009567.1 818450 819358 R Required for efficient pilin antigenic variation; recombination associated protein complement(818450..819358) Haemophilus influenzae PittGG 5227326 YP_001292214.1 CDS CGSHiGG_04350 NC_009567.1 819424 820239 D catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 819424..820239 Haemophilus influenzae PittGG 5227327 YP_001292215.1 CDS CGSHiGG_04355 NC_009567.1 820309 821406 D putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; putative 3-phenylpropionic acid transporter 820309..821406 Haemophilus influenzae PittGG 5227328 YP_001292216.1 CDS xerD NC_009567.1 821437 822330 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 821437..822330 Haemophilus influenzae PittGG 5227329 YP_001292217.1 CDS CGSHiGG_04365 NC_009567.1 822503 822790 D COG1196 Chromosome segregation ATPases; hypothetical protein 822503..822790 Haemophilus influenzae PittGG 5227330 YP_001292218.1 CDS ruvA NC_009567.1 823856 824470 R plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA complement(823856..824470) Haemophilus influenzae PittGG 5227331 YP_001292219.1 CDS ruvC NC_009567.1 824532 825104 R endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase complement(824532..825104) Haemophilus influenzae PittGG 5227332 YP_001292220.1 CDS CGSHiGG_04390 NC_009567.1 825151 825891 R COG0217 Uncharacterized conserved protein; hypothetical protein complement(825151..825891) Haemophilus influenzae PittGG 5227333 YP_001292221.1 CDS ntpA NC_009567.1 826051 826515 R converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase complement(826051..826515) Haemophilus influenzae PittGG 5227334 YP_001292222.1 CDS aspS NC_009567.1 826549 828315 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(826549..828315) Haemophilus influenzae PittGG 5227335 YP_001292223.1 CDS CGSHiGG_04405 NC_009567.1 828534 829052 D COG1755 Uncharacterized protein conserved in bacteria; hypothetical protein 828534..829052 Haemophilus influenzae PittGG 5227336 YP_001292224.1 CDS CGSHiGG_04410 NC_009567.1 829105 829830 D COG0500 SAM-dependent methyltransferases; hypothetical protein 829105..829830 Haemophilus influenzae PittGG 5227337 YP_001292225.1 CDS CGSHiGG_04415 NC_009567.1 829904 830311 D COG0346 Lactoylglutathione lyase and related lyases; lactoylglutathione lyase 829904..830311 Haemophilus influenzae PittGG 5227338 YP_001292226.1 CDS CGSHiGG_04420 NC_009567.1 830382 831071 D Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 830382..831071 Haemophilus influenzae PittGG 5227339 YP_001292227.1 CDS CGSHiGG_04425 NC_009567.1 831385 832737 D COG2056 Predicted permease; hypothetical protein 831385..832737 Haemophilus influenzae PittGG 5227340 YP_001292228.1 CDS CGSHiGG_04430 NC_009567.1 832770 833357 D COG3923 Primosomal replication protein N''; primosomal replication protein N 832770..833357 Haemophilus influenzae PittGG 5227341 YP_001292229.1 CDS CGSHiGG_04435 NC_009567.1 833709 834275 R Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P complement(833709..834275) Haemophilus influenzae PittGG 5227342 YP_001292230.1 CDS CGSHiGG_04450 NC_009567.1 835438 836724 D opacity associated protein 835438..836724 Haemophilus influenzae PittGG 5227343 YP_001292231.1 CDS CGSHiGG_04455 NC_009567.1 836783 837187 D COG3061 Cell envelope opacity-associated protein A; opacity associated protein OapB 836783..837187 Haemophilus influenzae PittGG 5227344 YP_001292232.1 CDS recO NC_009567.1 837190 837900 D involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 837190..837900 Haemophilus influenzae PittGG 5227345 YP_001292233.1 CDS rumA NC_009567.1 837900 839216 D in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 837900..839216 Haemophilus influenzae PittGG 5227346 YP_001292234.1 CDS CGSHiGG_04470 NC_009567.1 839294 841525 D COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; GTP pyrophosphokinase 839294..841525 Haemophilus influenzae PittGG 5227347 YP_001292235.1 CDS CGSHiGG_04475 NC_009567.1 841540 841896 D COG0818 Diacylglycerol kinase; diacylglycerol kinase 841540..841896 Haemophilus influenzae PittGG 5227348 YP_001292236.1 CDS mogA NC_009567.1 841979 842572 D forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 841979..842572 Haemophilus influenzae PittGG 5227349 YP_001292237.1 CDS CGSHiGG_04485 NC_009567.1 842574 842912 D COG0347 Nitrogen regulatory protein PII; nitrogen regulatory protein P-II 842574..842912 Haemophilus influenzae PittGG 5227350 YP_001292238.1 CDS CGSHiGG_04490 NC_009567.1 842912 843958 D COG0628 Predicted permease; hypothetical protein 842912..843958 Haemophilus influenzae PittGG 5227351 YP_001292239.1 CDS trmB NC_009567.1 846275 847015 D tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 846275..847015 Haemophilus influenzae PittGG 5227352 YP_001292240.1 CDS CGSHiGG_04510 NC_009567.1 847100 847444 D COG3171 Uncharacterized protein conserved in bacteria; hypothetical protein 847100..847444 Haemophilus influenzae PittGG 5227353 YP_001292241.1 CDS CGSHiGG_04515 NC_009567.1 847650 848093 D COG1145 Ferredoxin; ferredoxin-type protein NapF 847650..848093 Haemophilus influenzae PittGG 5227354 YP_001292242.1 CDS CGSHiGG_04520 NC_009567.1 848174 848455 D COG3062 Uncharacterized protein involved in formation of periplasmic nitrate reductase; hypothetical protein 848174..848455 Haemophilus influenzae PittGG 5227355 YP_001292243.1 CDS napG NC_009567.1 851029 851868 D part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component 851029..851868 Haemophilus influenzae PittGG 5227356 YP_001292244.1 CDS napH NC_009567.1 851868 852731 D part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component 851868..852731 Haemophilus influenzae PittGG 5227357 YP_001292245.1 CDS CGSHiGG_04545 NC_009567.1 852737 853180 D hypothetical protein 852737..853180 Haemophilus influenzae PittGG 5227358 YP_001292246.1 CDS CGSHiGG_04550 NC_009567.1 853195 853797 D hypothetical protein 853195..853797 Haemophilus influenzae PittGG 5227359 YP_001292247.1 CDS adk NC_009567.1 853956 854600 R essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase complement(853956..854600) Haemophilus influenzae PittGG 5227360 YP_001292248.1 CDS CGSHiGG_04560 NC_009567.1 854685 855923 R hypothetical protein complement(854685..855923) Haemophilus influenzae PittGG 5227361 YP_001292249.1 CDS CGSHiGG_04565 NC_009567.1 856104 857120 R UDP-glucose 4-epimerase complement(856104..857120) Haemophilus influenzae PittGG 5227362 YP_001292250.1 CDS CGSHiGG_04570 NC_009567.1 857293 858273 R hypothetical protein complement(857293..858273) Haemophilus influenzae PittGG 5227363 YP_001292251.1 CDS CGSHiGG_04575 NC_009567.1 858657 859379 D hypothetical protein 858657..859379 Haemophilus influenzae PittGG 5227364 YP_001292252.1 CDS CGSHiGG_04590 NC_009567.1 860135 861079 D hypothetical protein 860135..861079 Haemophilus influenzae PittGG 5227365 YP_001292253.1 CDS CGSHiGG_04595 NC_009567.1 861089 861736 D hypothetical protein 861089..861736 Haemophilus influenzae PittGG 5227366 YP_001292254.1 CDS CGSHiGG_04600 NC_009567.1 861854 862669 R hypothetical protein complement(861854..862669) Haemophilus influenzae PittGG 5227367 YP_001292255.1 CDS CGSHiGG_04605 NC_009567.1 862662 863510 R hypothetical protein complement(862662..863510) Haemophilus influenzae PittGG 5227368 YP_001292256.1 CDS CGSHiGG_04620 NC_009567.1 864435 865316 R hypothetical protein complement(864435..865316) Haemophilus influenzae PittGG 5227369 YP_001292257.1 CDS CGSHiGG_04625 NC_009567.1 865682 866560 R hypothetical protein complement(865682..866560) Haemophilus influenzae PittGG 5227370 YP_001292258.1 CDS CGSHiGG_04640 NC_009567.1 868060 868599 D hypothetical protein 868060..868599 Haemophilus influenzae PittGG 5227371 YP_001292259.1 CDS CGSHiGG_04645 NC_009567.1 868671 869582 D hypothetical protein 868671..869582 Haemophilus influenzae PittGG 5227372 YP_001292260.1 CDS ispG NC_009567.1 869591 870697 D catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 869591..870697 Haemophilus influenzae PittGG 5227373 YP_001292261.1 CDS hisS NC_009567.1 870707 871978 D catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 870707..871978 Haemophilus influenzae PittGG 5227374 YP_001292262.1 CDS CGSHiGG_04660 NC_009567.1 871996 872610 D hypothetical protein 871996..872610 Haemophilus influenzae PittGG 5227375 YP_001292263.1 CDS CGSHiGG_04665 NC_009567.1 872661 872855 R hypothetical protein complement(872661..872855) Haemophilus influenzae PittGG 5227376 YP_001292264.1 CDS CGSHiGG_04670 NC_009567.1 872855 873196 R hypothetical protein complement(872855..873196) Haemophilus influenzae PittGG 5227377 YP_001292265.1 CDS hscA NC_009567.1 873236 875095 R involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA complement(873236..875095) Haemophilus influenzae PittGG 5227378 YP_001292266.1 CDS CGSHiGG_04680 NC_009567.1 875114 875800 R hypothetical protein complement(875114..875800) Haemophilus influenzae PittGG 5227379 YP_001292267.1 CDS hscB NC_009567.1 875851 876375 R J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB complement(875851..876375) Haemophilus influenzae PittGG 5227380 YP_001292268.1 CDS CGSHiGG_04690 NC_009567.1 876388 876711 R hypothetical protein complement(876388..876711) Haemophilus influenzae PittGG 5227381 YP_001292269.1 CDS CGSHiGG_04695 NC_009567.1 876767 877147 R scaffold protein complement(876767..877147) Haemophilus influenzae PittGG 5227382 YP_001292270.1 CDS CGSHiGG_04700 NC_009567.1 877207 878421 R catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase complement(877207..878421) Haemophilus influenzae PittGG 5227383 YP_001292271.1 CDS CGSHiGG_04705 NC_009567.1 878488 878940 R hypothetical protein complement(878488..878940) Haemophilus influenzae PittGG 5227384 YP_001292272.1 CDS CGSHiGG_04710 NC_009567.1 878993 879718 R hypothetical protein complement(878993..879718) Haemophilus influenzae PittGG 5227385 YP_001292273.1 CDS CGSHiGG_04715 NC_009567.1 880367 880825 R hypothetical protein complement(880367..880825) Haemophilus influenzae PittGG 5227386 YP_001292274.1 CDS CGSHiGG_04720 NC_009567.1 880822 881421 R hypothetical protein complement(880822..881421) Haemophilus influenzae PittGG 5227387 YP_001292275.1 CDS CGSHiGG_04735 NC_009567.1 883508 884122 R hypothetical protein complement(883508..884122) Haemophilus influenzae PittGG 5227388 YP_001292276.1 CDS CGSHiGG_04740 NC_009567.1 884131 885567 R hypothetical protein complement(884131..885567) Haemophilus influenzae PittGG 5227389 YP_001292277.1 CDS CGSHiGG_04745 NC_009567.1 885560 885925 R hypothetical protein complement(885560..885925) Haemophilus influenzae PittGG 5227390 YP_001292278.1 CDS CGSHiGG_04750 NC_009567.1 885922 886593 R hypothetical protein complement(885922..886593) Haemophilus influenzae PittGG 5227391 YP_001292279.1 CDS CGSHiGG_04755 NC_009567.1 886596 887552 R hypothetical protein complement(886596..887552) Haemophilus influenzae PittGG 5227392 YP_001292280.1 CDS CGSHiGG_04760 NC_009567.1 887549 887863 R hypothetical protein complement(887549..887863) Haemophilus influenzae PittGG 5227393 YP_001292281.1 CDS CGSHiGG_04765 NC_009567.1 887860 888441 R hypothetical protein complement(887860..888441) Haemophilus influenzae PittGG 5227394 YP_001292282.1 CDS CGSHiGG_04770 NC_009567.1 888532 890862 R hypothetical protein complement(888532..890862) Haemophilus influenzae PittGG 5227395 YP_001292283.1 CDS CGSHiGG_04775 NC_009567.1 890859 891011 R hypothetical protein complement(890859..891011) Haemophilus influenzae PittGG 5227396 YP_001292284.1 CDS CGSHiGG_04780 NC_009567.1 891047 891529 R hypothetical protein complement(891047..891529) Haemophilus influenzae PittGG 5227397 YP_001292285.1 CDS CGSHiGG_04785 NC_009567.1 891516 891953 R hypothetical protein complement(891516..891953) Haemophilus influenzae PittGG 5227398 YP_001292286.1 CDS CGSHiGG_04790 NC_009567.1 891999 893072 R hypothetical protein complement(891999..893072) Haemophilus influenzae PittGG 5227399 YP_001292287.1 CDS CGSHiGG_04795 NC_009567.1 893059 893568 R hypothetical protein complement(893059..893568) Haemophilus influenzae PittGG 5227400 YP_001292288.1 CDS CGSHiGG_04800 NC_009567.1 893570 893929 R hypothetical protein complement(893570..893929) Haemophilus influenzae PittGG 5227401 YP_001292289.1 CDS CGSHiGG_04805 NC_009567.1 893929 894387 R hypothetical protein complement(893929..894387) Haemophilus influenzae PittGG 5227402 YP_001292290.1 CDS CGSHiGG_04810 NC_009567.1 894433 894729 R hypothetical protein complement(894433..894729) Haemophilus influenzae PittGG 5227403 YP_001292291.1 CDS CGSHiGG_04815 NC_009567.1 894733 894921 R hypothetical protein complement(894733..894921) Haemophilus influenzae PittGG 5227404 YP_001292292.1 CDS CGSHiGG_04820 NC_009567.1 894924 895871 R hypothetical protein complement(894924..895871) Haemophilus influenzae PittGG 5227405 YP_001292293.1 CDS CGSHiGG_04825 NC_009567.1 895933 896352 R hypothetical protein complement(895933..896352) Haemophilus influenzae PittGG 5227406 YP_001292294.1 CDS CGSHiGG_04830 NC_009567.1 896365 897438 R hypothetical protein complement(896365..897438) Haemophilus influenzae PittGG 5227407 YP_001292295.1 CDS CGSHiGG_04835 NC_009567.1 897564 898781 R hypothetical protein complement(897564..898781) Haemophilus influenzae PittGG 5227408 YP_001292296.1 CDS CGSHiGG_04840 NC_009567.1 898762 900078 R hypothetical protein complement(898762..900078) Haemophilus influenzae PittGG 5227409 YP_001292297.1 CDS CGSHiGG_04845 NC_009567.1 900080 901429 R hypothetical protein complement(900080..901429) Haemophilus influenzae PittGG 5227410 YP_001292298.1 CDS CGSHiGG_04850 NC_009567.1 901410 901778 R hypothetical protein complement(901410..901778) Haemophilus influenzae PittGG 5227411 YP_001292299.1 CDS CGSHiGG_04855 NC_009567.1 901836 902057 D hypothetical protein 901836..902057 Haemophilus influenzae PittGG 5227412 YP_001292300.1 CDS CGSHiGG_04860 NC_009567.1 902054 903409 R hypothetical protein complement(902054..903409) Haemophilus influenzae PittGG 5227413 YP_001292301.1 CDS CGSHiGG_04865 NC_009567.1 903421 903651 R hypothetical protein complement(903421..903651) Haemophilus influenzae PittGG 5227414 YP_001292302.1 CDS CGSHiGG_04870 NC_009567.1 903626 904015 R hypothetical protein complement(903626..904015) Haemophilus influenzae PittGG 5227415 YP_001292303.1 CDS CGSHiGG_04875 NC_009567.1 904012 904416 R hypothetical protein complement(904012..904416) Haemophilus influenzae PittGG 5227416 YP_001292304.1 CDS CGSHiGG_04880 NC_009567.1 904403 904570 R hypothetical protein complement(904403..904570) Haemophilus influenzae PittGG 5227417 YP_001292305.1 CDS CGSHiGG_04885 NC_009567.1 904922 905692 R hypothetical protein complement(904922..905692) Haemophilus influenzae PittGG 5227418 YP_001292306.1 CDS CGSHiGG_04890 NC_009567.1 905817 906023 D hypothetical protein 905817..906023 Haemophilus influenzae PittGG 5227419 YP_001292307.1 CDS CGSHiGG_04895 NC_009567.1 906565 906798 D hypothetical protein 906565..906798 Haemophilus influenzae PittGG 5227420 YP_001292308.1 CDS CGSHiGG_04900 NC_009567.1 906800 907582 D hypothetical protein 906800..907582 Haemophilus influenzae PittGG 5227421 YP_001292309.1 CDS CGSHiGG_04915 NC_009567.1 908200 908424 D hypothetical protein 908200..908424 Haemophilus influenzae PittGG 5227422 YP_001292310.1 CDS CGSHiGG_04920 NC_009567.1 908461 908877 D hypothetical protein 908461..908877 Haemophilus influenzae PittGG 5227423 YP_001292311.1 CDS CGSHiGG_04925 NC_009567.1 908878 908970 D hypothetical protein 908878..908970 Haemophilus influenzae PittGG 5227424 YP_001292312.1 CDS CGSHiGG_04930 NC_009567.1 908970 909581 D hypothetical protein 908970..909581 Haemophilus influenzae PittGG 5227425 YP_001292313.1 CDS CGSHiGG_04935 NC_009567.1 909560 909925 D hypothetical protein 909560..909925 Haemophilus influenzae PittGG 5227426 YP_001292314.1 CDS CGSHiGG_04940 NC_009567.1 910048 910848 D hypothetical protein 910048..910848 Haemophilus influenzae PittGG 5227427 YP_001292315.1 CDS CGSHiGG_04945 NC_009567.1 910859 912007 D hypothetical protein 910859..912007 Haemophilus influenzae PittGG 5227428 YP_001292316.1 CDS CGSHiGG_04950 NC_009567.1 912157 912342 D hypothetical protein 912157..912342 Haemophilus influenzae PittGG 5227429 YP_001292317.1 CDS CGSHiGG_04955 NC_009567.1 912732 913043 D hypothetical protein 912732..913043 Haemophilus influenzae PittGG 5226336 YP_001292318.1 CDS CGSHiGG_04960 NC_009567.1 913163 913414 D hypothetical protein 913163..913414 Haemophilus influenzae PittGG 5226337 YP_001292319.1 CDS CGSHiGG_04965 NC_009567.1 913404 914435 D hypothetical protein 913404..914435 Haemophilus influenzae PittGG 5226338 YP_001292320.1 CDS CGSHiGG_04970 NC_009567.1 914526 915257 D hypothetical protein 914526..915257 Haemophilus influenzae PittGG 5226339 YP_001292321.1 CDS CGSHiGG_04975 NC_009567.1 915278 915622 D hypothetical protein 915278..915622 Haemophilus influenzae PittGG 5226340 YP_001292322.1 CDS CGSHiGG_04980 NC_009567.1 915619 915912 D hypothetical protein 915619..915912 Haemophilus influenzae PittGG 5226341 YP_001292323.1 CDS CGSHiGG_04985 NC_009567.1 915925 916845 D hypothetical protein 915925..916845 Haemophilus influenzae PittGG 5226342 YP_001292324.1 CDS CGSHiGG_04990 NC_009567.1 916820 917470 D hypothetical protein 916820..917470 Haemophilus influenzae PittGG 5226343 YP_001292325.1 CDS CGSHiGG_04995 NC_009567.1 917470 917904 D hypothetical protein 917470..917904 Haemophilus influenzae PittGG 5226344 YP_001292326.1 CDS CGSHiGG_05000 NC_009567.1 917967 918746 D hypothetical protein 917967..918746 Haemophilus influenzae PittGG 5226345 YP_001292327.1 CDS rdgC NC_009567.1 918852 919763 D Required for efficient pilin antigenic variation; recombination associated protein 918852..919763 Haemophilus influenzae PittGG 5226346 YP_001292328.1 CDS CGSHiGG_05010 NC_009567.1 919760 920005 D hypothetical protein 919760..920005 Haemophilus influenzae PittGG 5226347 YP_001292329.1 CDS CGSHiGG_05015 NC_009567.1 920002 920361 D hypothetical protein 920002..920361 Haemophilus influenzae PittGG 5226348 YP_001292330.1 CDS CGSHiGG_05020 NC_009567.1 920369 921643 D hypothetical protein 920369..921643 Haemophilus influenzae PittGG 5226349 YP_001292331.1 CDS CGSHiGG_05025 NC_009567.1 921694 922215 D hypothetical protein 921694..922215 Haemophilus influenzae PittGG 5226350 YP_001292332.1 CDS CGSHiGG_05030 NC_009567.1 922269 922346 D hypothetical protein 922269..922346 Haemophilus influenzae PittGG 5226351 YP_001292333.1 CDS CGSHiGG_05035 NC_009567.1 922350 922766 D hypothetical protein 922350..922766 Haemophilus influenzae PittGG 5226352 YP_001292334.1 CDS CGSHiGG_05040 NC_009567.1 922838 923371 D hypothetical protein 922838..923371 Haemophilus influenzae PittGG 5226353 YP_001292335.1 CDS CGSHiGG_05045 NC_009567.1 923361 923684 D hypothetical protein 923361..923684 Haemophilus influenzae PittGG 5226354 YP_001292336.1 CDS CGSHiGG_05050 NC_009567.1 923677 924021 D hypothetical protein 923677..924021 Haemophilus influenzae PittGG 5226355 YP_001292337.1 CDS CGSHiGG_05055 NC_009567.1 924073 924387 D hypothetical protein 924073..924387 Haemophilus influenzae PittGG 5226356 YP_001292338.1 CDS CGSHiGG_05060 NC_009567.1 924429 925310 D hypothetical protein 924429..925310 Haemophilus influenzae PittGG 5226357 YP_001292339.1 CDS CGSHiGG_05065 NC_009567.1 925744 926205 R hypothetical protein complement(925744..926205) Haemophilus influenzae PittGG 5226358 YP_001292340.1 CDS tolB NC_009567.1 926229 927512 R forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB complement(926229..927512) Haemophilus influenzae PittGG 5226359 YP_001292341.1 CDS tolA NC_009567.1 927554 928786 R inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA complement(927554..928786) Haemophilus influenzae PittGG 5226360 YP_001292342.1 CDS CGSHiGG_05080 NC_009567.1 928802 929221 R membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR complement(928802..929221) Haemophilus influenzae PittGG 5226361 YP_001292343.1 CDS CGSHiGG_05095 NC_009567.1 929996 930406 R hypothetical protein complement(929996..930406) Haemophilus influenzae PittGG 5226362 YP_001292344.1 CDS CGSHiGG_05110 NC_009567.1 932669 933379 D hypothetical protein 932669..933379 Haemophilus influenzae PittGG 5226363 YP_001292345.1 CDS CGSHiGG_05115 NC_009567.1 933404 933955 D hypothetical protein 933404..933955 Haemophilus influenzae PittGG 5226364 YP_001292346.1 CDS CGSHiGG_05130 NC_009567.1 935686 936891 D COG0349 Ribonuclease D; ribonuclease D 935686..936891 Haemophilus influenzae PittGG 5226365 YP_001292347.1 CDS CGSHiGG_05135 NC_009567.1 936928 938820 R COG1835 Predicted acyltransferases; long-chain-fatty-acid--CoA ligase complement(936928..938820) Haemophilus influenzae PittGG 5226366 YP_001292348.1 CDS CGSHiGG_05140 NC_009567.1 938894 939985 R translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD complement(938894..939985) Haemophilus influenzae PittGG 5226367 YP_001292349.1 CDS CGSHiGG_05145 NC_009567.1 940033 940617 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(940033..940617) Haemophilus influenzae PittGG 5226368 YP_001292350.1 CDS CGSHiGG_05150 NC_009567.1 940800 941108 D COG2914 Uncharacterized protein conserved in bacteria; hypothetical protein 940800..941108 Haemophilus influenzae PittGG 5226369 YP_001292351.1 CDS CGSHiGG_05155 NC_009567.1 941111 942325 D COG2850 Uncharacterized conserved protein; hypothetical protein 941111..942325 Haemophilus influenzae PittGG 5226370 YP_001292352.1 CDS xseA NC_009567.1 942318 943646 D bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 942318..943646 Haemophilus influenzae PittGG 5226371 YP_001292353.1 CDS xseA NC_009567.1 943844 944476 D COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; exodeoxyribonuclease VII large subunit 943844..944476 Haemophilus influenzae PittGG 5226372 YP_001292354.1 CDS CGSHiGG_05170 NC_009567.1 944485 945309 D COG1409 Predicted phosphohydrolases; cyclic 3',5'-adenosine monophosphate phosphodiesterase 944485..945309 Haemophilus influenzae PittGG 5226373 YP_001292355.1 CDS CGSHiGG_05175 NC_009567.1 945407 945694 R COG3691 Uncharacterized protein conserved in bacteria; hypothetical protein complement(945407..945694) Haemophilus influenzae PittGG 5226374 YP_001292356.1 CDS CGSHiGG_05180 NC_009567.1 945901 947274 D COG2067 Long-chain fatty acid transport protein; long-chain fatty acid transport protein 945901..947274 Haemophilus influenzae PittGG 5226375 YP_001292357.1 CDS CGSHiGG_05185 NC_009567.1 947348 947887 D COG0350 Methylated DNA-protein cysteine methyltransferase; cyclic 3',5'-adenosine monophosphate phosphodiesterase 947348..947887 Haemophilus influenzae PittGG 5226376 YP_001292358.1 CDS CGSHiGG_05190 NC_009567.1 947884 948555 D MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 947884..948555 Haemophilus influenzae PittGG 5226377 YP_001292359.1 CDS CGSHiGG_05195 NC_009567.1 948563 949855 R COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control; cell cycle protein complement(948563..949855) Haemophilus influenzae PittGG 5226378 YP_001292360.1 CDS CGSHiGG_05200 NC_009567.1 949855 949959 R COG2240 Pyridoxal/pyridoxine/pyridoxamine kinase; DNA mismatch repair protein complement(949855..949959) Haemophilus influenzae PittGG 5226379 YP_001292361.1 CDS CGSHiGG_05215 NC_009567.1 951067 951852 R COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; high-affinity zinc uptake system membrane protein ZnuB complement(951067..951852) Haemophilus influenzae PittGG 5226380 YP_001292362.1 CDS CGSHiGG_05220 NC_009567.1 951852 952658 R COG1121 ABC-type Mn/Zn transport systems, ATPase component; ABC transporter ATP-binding protein complement(951852..952658) Haemophilus influenzae PittGG 5226381 YP_001292363.1 CDS CGSHiGG_05235 NC_009567.1 954374 955330 D COG3283 Transcriptional regulator of aromatic amino acids metabolism; transcriptional regulatory protein TyrR 954374..955330 Haemophilus influenzae PittGG 5226382 YP_001292364.1 CDS hfq NC_009567.1 955426 955701 R Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq complement(955426..955701) Haemophilus influenzae PittGG 5226383 YP_001292365.1 CDS CGSHiGG_05245 NC_009567.1 955792 956760 R catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C complement(955792..956760) Haemophilus influenzae PittGG 5226384 YP_001292366.1 CDS CGSHiGG_05250 NC_009567.1 957181 959988 D ribonuclease E 957181..959988 Haemophilus influenzae PittGG 5226385 YP_001292367.1 CDS CGSHiGG_05255 NC_009567.1 960142 960378 D COG1530 Ribonucleases G and E; 23S rRNA pseudouridylate synthase C 960142..960378 Haemophilus influenzae PittGG 5226386 YP_001292368.1 CDS CGSHiGG_05260 NC_009567.1 960708 961499 D catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 960708..961499 Haemophilus influenzae PittGG 5226387 YP_001292369.1 CDS thiE NC_009567.1 962311 962991 D Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 962311..962991 Haemophilus influenzae PittGG 5226388 YP_001292370.1 CDS CGSHiGG_05290 NC_009567.1 964290 964391 R COG0477 Permeases of the major facilitator superfamily; hypothetical protein complement(964290..964391) Haemophilus influenzae PittGG 5226389 YP_001292371.1 CDS CGSHiGG_05305 NC_009567.1 965974 966273 D COG4453 Uncharacterized protein conserved in bacteria; hypothetical protein 965974..966273 Haemophilus influenzae PittGG 5226390 YP_001292372.1 CDS CGSHiGG_05310 NC_009567.1 966263 966781 D COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; histone acetyltransferase 966263..966781 Haemophilus influenzae PittGG 5226391 YP_001292373.1 CDS thiE NC_009567.1 966927 967529 R COG5295 Autotransporter adhesin; thiamine-phosphate pyrophosphorylase complement(966927..967529) Haemophilus influenzae PittGG 5226392 YP_001292374.1 CDS CGSHiGG_05320 NC_009567.1 967717 969036 R facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB complement(967717..969036) Haemophilus influenzae PittGG 5226393 YP_001292375.1 CDS CGSHiGG_05325 NC_009567.1 969106 969804 D COG4123 Predicted O-methyltransferase; hypothetical protein 969106..969804 Haemophilus influenzae PittGG 5226394 YP_001292376.1 CDS CGSHiGG_05330 NC_009567.1 969836 970951 R COG0566 rRNA methylases; ATP-dependent RNA helicase SrmB complement(969836..970951) Haemophilus influenzae PittGG 5226395 YP_001292377.1 CDS pssA NC_009567.1 971037 972404 D catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 971037..972404 Haemophilus influenzae PittGG 5226396 YP_001292378.1 CDS CGSHiGG_05340 NC_009567.1 972449 973174 R Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator complement(972449..973174) Haemophilus influenzae PittGG 5226397 YP_001292379.1 CDS CGSHiGG_05355 NC_009567.1 974852 975385 D disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 974852..975385 Haemophilus influenzae PittGG 5226398 YP_001292380.1 CDS CGSHiGG_05370 NC_009567.1 977385 977657 R COG0776 Bacterial nucleoid DNA-binding protein; DNA-binding protein HU complement(977385..977657) Haemophilus influenzae PittGG 5226399 YP_001292381.1 CDS CGSHiGG_05375 NC_009567.1 977797 978387 R COG3068 Uncharacterized protein conserved in bacteria; hypothetical protein complement(977797..978387) Haemophilus influenzae PittGG 5226400 YP_001292382.1 CDS nudC NC_009567.1 978423 979217 R can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase complement(978423..979217) Haemophilus influenzae PittGG 5226401 YP_001292383.1 CDS CGSHiGG_05385 NC_009567.1 979284 979880 R cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; putative DNA uptake protein complement(979284..979880) Haemophilus influenzae PittGG 5226402 YP_001292384.1 CDS CGSHiGG_05390 NC_009567.1 979956 980642 R COG1040 Predicted amidophosphoribosyltransferases; competence protein F complement(979956..980642) Haemophilus influenzae PittGG 5226403 YP_001292385.1 CDS CGSHiGG_05395 NC_009567.1 980655 981992 R competence protein E complement(980655..981992) Haemophilus influenzae PittGG 5226404 YP_001292386.1 CDS CGSHiGG_05400 NC_009567.1 982002 982415 R competence protein D complement(982002..982415) Haemophilus influenzae PittGG 5226405 YP_001292387.1 CDS CGSHiGG_05405 NC_009567.1 982412 982933 R competence protein C complement(982412..982933) Haemophilus influenzae PittGG 5226406 YP_001292388.1 CDS CGSHiGG_05410 NC_009567.1 982930 983436 R competence protein B complement(982930..983436) Haemophilus influenzae PittGG 5226407 YP_001292389.1 CDS CGSHiGG_05415 NC_009567.1 983437 984234 R COG4796 Type II secretory pathway, component HofQ; competence protein A complement(983437..984234) Haemophilus influenzae PittGG 5226408 YP_001292390.1 CDS CGSHiGG_05420 NC_009567.1 984333 986927 D COG5009 Membrane carboxypeptidase/penicillin-binding protein; penicillin-binding protein 1A 984333..986927 Haemophilus influenzae PittGG 5226409 YP_001292391.1 CDS CGSHiGG_05435 NC_009567.1 987997 988326 D COG0718 Uncharacterized protein conserved in bacteria; hypothetical protein 987997..988326 Haemophilus influenzae PittGG 5226410 YP_001292392.1 CDS recR NC_009567.1 988384 988986 D involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 988384..988986 Haemophilus influenzae PittGG 5226411 YP_001292393.1 CDS CGSHiGG_05445 NC_009567.1 989002 990957 D decatenates replicating daughter chromosomes; DNA topoisomerase III 989002..990957 Haemophilus influenzae PittGG 5226412 YP_001292394.1 CDS secG NC_009567.1 991066 991407 D COG1314 Preprotein translocase subunit SecG; preprotein translocase subunit SecG 991066..991407 Haemophilus influenzae PittGG 5226413 YP_001292395.1 CDS secG NC_009567.1 991952 993622 R COG3925 N-terminal domain of the phosphotransferase system fructose-specific component IIB; preprotein translocase subunit SecG complement(991952..993622) Haemophilus influenzae PittGG 5226414 YP_001292396.1 CDS fruK NC_009567.1 993624 994565 R converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase complement(993624..994565) Haemophilus influenzae PittGG 5226415 YP_001292397.1 CDS CGSHiGG_05465 NC_009567.1 994567 996066 R phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein complement(994567..996066) Haemophilus influenzae PittGG 5226416 YP_001292398.1 CDS CGSHiGG_05470 NC_009567.1 996138 996668 R COG4668 Mannitol/fructose-specific phosphotransferase system, IIA domain; hypothetical protein complement(996138..996668) Haemophilus influenzae PittGG 5226417 YP_001292399.1 CDS CGSHiGG_05475 NC_009567.1 996761 997039 R virulence-associated protein D complement(996761..997039) Haemophilus influenzae PittGG 5226418 YP_001292400.1 CDS CGSHiGG_05480 NC_009567.1 997048 997239 R COG3309 Uncharacterized virulence-associated protein D; hypothetical protein complement(997048..997239) Haemophilus influenzae PittGG 5226419 YP_001292401.1 CDS CGSHiGG_05495 NC_009567.1 998659 999183 R COG1253 Hemolysins and related proteins containing CBS domains; hypothetical protein complement(998659..999183) Haemophilus influenzae PittGG 5226420 YP_001292402.1 CDS CGSHiGG_05500 NC_009567.1 999210 999992 R COG0084 Mg-dependent DNase; fused fructose-specific PTS enzymes: IIA component/HPr component complement(999210..999992) Haemophilus influenzae PittGG 5226421 YP_001292403.1 CDS CGSHiGG_05505 NC_009567.1 1000031 1001011 R catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' complement(1000031..1001011) Haemophilus influenzae PittGG 5226422 YP_001292404.1 CDS CGSHiGG_05510 NC_009567.1 1001211 1001315 D COG0470 ATPase involved in DNA replication; hypothetical protein 1001211..1001315 Haemophilus influenzae PittGG 5226423 YP_001292405.1 CDS CGSHiGG_05515 NC_009567.1 1001351 1003522 D COG3468 Type V secretory pathway, adhesin AidA; DNA polymerase III subunit delta' 1001351..1003522 Haemophilus influenzae PittGG 5226424 YP_001292406.1 CDS tmk NC_009567.1 1003587 1004219 R catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase complement(1003587..1004219) Haemophilus influenzae PittGG 5226425 YP_001292407.1 CDS CGSHiGG_05525 NC_009567.1 1004236 1005279 R COG1559 Predicted periplasmic solute-binding protein; periplasmic solute-binding protein complement(1004236..1005279) Haemophilus influenzae PittGG 5226426 YP_001292408.1 CDS tdk NC_009567.1 1005351 1006286 R COG0760 Parvulin-like peptidyl-prolyl isomerase; thymidylate kinase complement(1005351..1006286) Haemophilus influenzae PittGG 5226427 YP_001292409.1 CDS CGSHiGG_05535 NC_009567.1 1006363 1006902 R regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase complement(1006363..1006902) Haemophilus influenzae PittGG 5226428 YP_001292410.1 CDS mazG NC_009567.1 1007034 1007825 D functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase 1007034..1007825 Haemophilus influenzae PittGG 5226429 YP_001292411.1 CDS CGSHiGG_05545 NC_009567.1 1007874 1008749 R COG2990 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1007874..1008749) Haemophilus influenzae PittGG 5226430 YP_001292412.1 CDS mazG NC_009567.1 1008943 1011354 D COG0466 ATP-dependent Lon protease, bacterial type; nucleoside triphosphate pyrophosphohydrolase 1008943..1011354 Haemophilus influenzae PittGG 5226431 YP_001292413.1 CDS CGSHiGG_05555 NC_009567.1 1011470 1012621 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 1011470..1012621 Haemophilus influenzae PittGG 5226432 YP_001292414.1 CDS CGSHiGG_05560 NC_009567.1 1012754 1013413 D Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 1012754..1013413 Haemophilus influenzae PittGG 5226433 YP_001292415.1 CDS CGSHiGG_05565 NC_009567.1 1013443 1014675 D catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 1013443..1014675 Haemophilus influenzae PittGG 5226434 YP_001292416.1 CDS CGSHiGG_05570 NC_009567.1 1014718 1015560 R COG0354 Predicted aminomethyltransferase related to GcvT; D-3-phosphoglycerate dehydrogenase complement(1014718..1015560) Haemophilus influenzae PittGG 5226435 YP_001292417.1 CDS CGSHiGG_05575 NC_009567.1 1015570 1016433 R hypothetical protein complement(1015570..1016433) Haemophilus influenzae PittGG 5226436 YP_001292418.1 CDS CGSHiGG_05580 NC_009567.1 1016452 1016718 R COG1561 Uncharacterized stress-induced protein; hypothetical protein complement(1016452..1016718) Haemophilus influenzae PittGG 5226437 YP_001292419.1 CDS hisG NC_009567.1 1016881 1017792 D long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 1016881..1017792 Haemophilus influenzae PittGG 5226438 YP_001292420.1 CDS hisD NC_009567.1 1017886 1019169 D catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 1017886..1019169 Haemophilus influenzae PittGG 5226439 YP_001292421.1 CDS CGSHiGG_05595 NC_009567.1 1019283 1020341 D catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 1019283..1020341 Haemophilus influenzae PittGG 5226440 YP_001292422.1 CDS CGSHiGG_05600 NC_009567.1 1020453 1021541 D catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 1020453..1021541 Haemophilus influenzae PittGG 5226441 YP_001292423.1 CDS hisH NC_009567.1 1021607 1022206 D with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 1021607..1022206 Haemophilus influenzae PittGG 5226442 YP_001292424.1 CDS CGSHiGG_05610 NC_009567.1 1022242 1022991 D catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 1022242..1022991 Haemophilus influenzae PittGG 5226443 YP_001292425.1 CDS CGSHiGG_05635 NC_009567.1 1024498 1024650 D COG0140 Phosphoribosyl-ATP pyrophosphohydrolase; hypothetical protein 1024498..1024650 Haemophilus influenzae PittGG 5226444 YP_001292426.1 CDS CGSHiGG_05640 NC_009567.1 1024680 1025882 D COG0814 Amino acid permeases; imidazole glycerol phosphate synthase subunit HisF 1024680..1025882 Haemophilus influenzae PittGG 5226445 YP_001292427.1 CDS atpC NC_009567.1 1026069 1026497 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon complement(1026069..1026497) Haemophilus influenzae PittGG 5226446 YP_001292428.1 CDS CGSHiGG_05650 NC_009567.1 1026527 1027900 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta complement(1026527..1027900) Haemophilus influenzae PittGG 5226447 YP_001292429.1 CDS CGSHiGG_05655 NC_009567.1 1027917 1028786 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma complement(1027917..1028786) Haemophilus influenzae PittGG 5226448 YP_001292430.1 CDS CGSHiGG_05660 NC_009567.1 1028802 1030343 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha complement(1028802..1030343) Haemophilus influenzae PittGG 5226449 YP_001292431.1 CDS CGSHiGG_05665 NC_009567.1 1030356 1030889 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta complement(1030356..1030889) Haemophilus influenzae PittGG 5226450 YP_001292432.1 CDS CGSHiGG_05670 NC_009567.1 1030902 1031372 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B complement(1030902..1031372) Haemophilus influenzae PittGG 5226451 YP_001292433.1 CDS CGSHiGG_05675 NC_009567.1 1031422 1031676 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C complement(1031422..1031676) Haemophilus influenzae PittGG 5226452 YP_001292434.1 CDS CGSHiGG_05680 NC_009567.1 1031732 1032520 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A complement(1031732..1032520) Haemophilus influenzae PittGG 5226453 YP_001292435.1 CDS CGSHiGG_05685 NC_009567.1 1032588 1032932 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I complement(1032588..1032932) Haemophilus influenzae PittGG 5226454 YP_001292436.1 CDS gidB NC_009567.1 1033058 1033669 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(1033058..1033669) Haemophilus influenzae PittGG 5226455 YP_001292437.1 CDS CGSHiGG_05695 NC_009567.1 1033807 1034184 R COG0357 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division; hypothetical protein complement(1033807..1034184) Haemophilus influenzae PittGG 5226456 YP_001292438.1 CDS CGSHiGG_05700 NC_009567.1 1034299 1034901 D COG0637 Predicted phosphatase/phosphohexomutase; putative phosphatase/phosphohexomutase 1034299..1034901 Haemophilus influenzae PittGG 5226457 YP_001292439.1 CDS gidB NC_009567.1 1034901 1035374 D COG1238 Predicted membrane protein; glucose-inhibited division protein B 1034901..1035374 Haemophilus influenzae PittGG 5226458 YP_001292440.1 CDS CGSHiGG_05710 NC_009567.1 1035702 1036205 D catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 1035702..1036205 Haemophilus influenzae PittGG 5226459 YP_001292441.1 CDS CGSHiGG_05715 NC_009567.1 1036305 1036511 D COG2963 Transposase and inactivated derivatives; hypothetical protein 1036305..1036511 Haemophilus influenzae PittGG 5226460 YP_001292442.1 CDS CGSHiGG_05720 NC_009567.1 1036842 1037057 D COG2801 Transposase and inactivated derivatives; S-ribosylhomocysteinase 1036842..1037057 Haemophilus influenzae PittGG 5226461 YP_001292443.1 CDS aphA NC_009567.1 1037149 1037856 R Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase complement(1037149..1037856) Haemophilus influenzae PittGG 5226462 YP_001292444.1 CDS CGSHiGG_05730 NC_009567.1 1038076 1038603 D heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 1038076..1038603 Haemophilus influenzae PittGG 5226463 YP_001292445.1 CDS CGSHiGG_05745 NC_009567.1 1040019 1041071 R COG0687 Spermidine/putrescine-binding periplasmic protein; spermidine/putrescine ABC transporter periplasmic-binding protein complement(1040019..1041071) Haemophilus influenzae PittGG 5226464 YP_001292446.1 CDS hslU NC_009567.1 1042671 1044113 D COG1322 Uncharacterized protein conserved in bacteria; ATP-dependent protease ATP-binding subunit 1042671..1044113 Haemophilus influenzae PittGG 5226465 YP_001292447.1 CDS CGSHiGG_05765 NC_009567.1 1044275 1044694 D cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 1044275..1044694 Haemophilus influenzae PittGG 5226466 YP_001292448.1 CDS CGSHiGG_05770 NC_009567.1 1044708 1046189 D with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP binding protein 1044708..1046189 Haemophilus influenzae PittGG 5226467 YP_001292449.1 CDS rbsC NC_009567.1 1046219 1047187 D functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease protein 1046219..1047187 Haemophilus influenzae PittGG 5226468 YP_001292450.1 CDS CGSHiGG_05780 NC_009567.1 1047207 1048085 D periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 1047207..1048085 Haemophilus influenzae PittGG 5226469 YP_001292451.1 CDS CGSHiGG_05785 NC_009567.1 1048183 1049103 D catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 1048183..1049103 Haemophilus influenzae PittGG 5226470 YP_001292452.1 CDS CGSHiGG_05790 NC_009567.1 1049131 1050129 D COG1609 Transcriptional regulators; ribokinase 1049131..1050129 Haemophilus influenzae PittGG 5226471 YP_001292453.1 CDS CGSHiGG_05795 NC_009567.1 1050235 1050786 D COG2862 Predicted membrane protein; hypothetical protein 1050235..1050786 Haemophilus influenzae PittGG 5226472 YP_001292454.1 CDS CGSHiGG_05800 NC_009567.1 1050926 1051414 R regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA complement(1050926..1051414) Haemophilus influenzae PittGG 5226473 YP_001292455.1 CDS CGSHiGG_05805 NC_009567.1 1051466 1052356 R catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase complement(1051466..1052356) Haemophilus influenzae PittGG 5226474 YP_001292456.1 CDS CGSHiGG_05810 NC_009567.1 1052439 1053158 D COG1720 Uncharacterized conserved protein; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 1052439..1053158 Haemophilus influenzae PittGG 5226475 YP_001292457.1 CDS CGSHiGG_05815 NC_009567.1 1053211 1054155 R COG1275 Tellurite resistance protein and related permeases; potassium-tellurite ethidium and proflavin transporter complement(1053211..1054155) Haemophilus influenzae PittGG 5226476 YP_001292458.1 CDS CGSHiGG_05820 NC_009567.1 1054349 1058599 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' complement(1054349..1058599) Haemophilus influenzae PittGG 5226477 YP_001292459.1 CDS rpoB NC_009567.1 1058807 1062745 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta complement(1058807..1062745) Haemophilus influenzae PittGG 5226478 YP_001292460.1 CDS rplA NC_009567.1 1063221 1063910 R in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 complement(1063221..1063910) Haemophilus influenzae PittGG 5226479 YP_001292461.1 CDS rplK NC_009567.1 1063915 1064343 R binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 complement(1063915..1064343) Haemophilus influenzae PittGG 5226480 YP_001292462.1 CDS deoD NC_009567.1 1064514 1065230 R catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase complement(1064514..1065230) Haemophilus influenzae PittGG 5226481 YP_001292463.1 CDS CGSHiGG_05845 NC_009567.1 1065314 1066567 R COG1972 Nucleoside permease; nucleoside permease complement(1065314..1066567) Haemophilus influenzae PittGG 5226482 YP_001292464.1 CDS deoD NC_009567.1 1066666 1067454 R COG1180 Pyruvate-formate lyase-activating enzyme; purine nucleoside phosphorylase complement(1066666..1067454) Haemophilus influenzae PittGG 5226483 YP_001292465.1 CDS CGSHiGG_05855 NC_009567.1 1067463 1069007 R COG1882 Pyruvate-formate lyase; hypothetical protein complement(1067463..1069007) Haemophilus influenzae PittGG 5226484 YP_001292466.1 CDS CGSHiGG_05860 NC_009567.1 1069220 1069876 D COG2364 Predicted membrane protein; hypothetical protein 1069220..1069876 Haemophilus influenzae PittGG 5226485 YP_001292467.1 CDS CGSHiGG_05865 NC_009567.1 1069832 1070872 R COG0859 ADP-heptose:LPS heptosyltransferase; hypothetical protein complement(1069832..1070872) Haemophilus influenzae PittGG 5226486 YP_001292468.1 CDS CGSHiGG_05870 NC_009567.1 1070940 1072019 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase complement(1070940..1072019) Haemophilus influenzae PittGG 5226487 YP_001292469.1 CDS pgk NC_009567.1 1072130 1073290 R Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase complement(1072130..1073290) Haemophilus influenzae PittGG 5226488 YP_001292470.1 CDS CGSHiGG_05880 NC_009567.1 1073386 1074180 R COG3719 Ribonuclease I; ribonuclease I complement(1073386..1074180) Haemophilus influenzae PittGG 5226489 YP_001292471.1 CDS CGSHiGG_05885 NC_009567.1 1074258 1074518 D COG1145 Ferredoxin; ferredoxin 1074258..1074518 Haemophilus influenzae PittGG 5226490 YP_001292472.1 CDS pgk NC_009567.1 1074656 1075876 R COG0814 Amino acid permeases; phosphoglycerate kinase complement(1074656..1075876) Haemophilus influenzae PittGG 5226491 YP_001292473.1 CDS CGSHiGG_05895 NC_009567.1 1075913 1076494 R catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase complement(1075913..1076494) Haemophilus influenzae PittGG 5226492 YP_001292474.1 CDS CGSHiGG_05900 NC_009567.1 1076503 1077531 R in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease complement(1076503..1077531) Haemophilus influenzae PittGG 5226493 YP_001292475.1 CDS rpsU NC_009567.1 1077763 1077978 D a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1077763..1077978 Haemophilus influenzae PittGG 5226494 YP_001292476.1 CDS dnaG NC_009567.1 1078112 1079893 D synthesizes RNA primers at the replication forks; DNA primase 1078112..1079893 Haemophilus influenzae PittGG 5226495 YP_001292477.1 CDS CGSHiGG_05915 NC_009567.1 1079963 1081852 D DNA primase 1079963..1081852 Haemophilus influenzae PittGG 5226496 YP_001292478.1 CDS CGSHiGG_05920 NC_009567.1 1082020 1082106 D COG0568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32); hypothetical protein 1082020..1082106 Haemophilus influenzae PittGG 5226497 YP_001292479.1 CDS aspA NC_009567.1 1082152 1083570 R catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase complement(1082152..1083570) Haemophilus influenzae PittGG 5226498 YP_001292480.1 CDS CGSHiGG_05930 NC_009567.1 1083725 1084468 R COG0829 Urease accessory protein UreH; urease accessory protein UreH complement(1083725..1084468) Haemophilus influenzae PittGG 5226499 YP_001292481.1 CDS CGSHiGG_05935 NC_009567.1 1084615 1085250 R COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; urease accessory protein complement(1084615..1085250) Haemophilus influenzae PittGG 5226500 YP_001292482.1 CDS CGSHiGG_05940 NC_009567.1 1085395 1086102 R COG0830 Urease accessory protein UreF; urease accessory protein UreF complement(1085395..1086102) Haemophilus influenzae PittGG 5226501 YP_001292483.1 CDS ureE NC_009567.1 1086087 1086644 R involved in the assembly of the urease metallocenter; possible nickel donor; urease accessory protein UreE complement(1086087..1086644) Haemophilus influenzae PittGG 5226502 YP_001292484.1 CDS ureC NC_009567.1 1086772 1088490 R ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha complement(1086772..1088490) Haemophilus influenzae PittGG 5226503 YP_001292485.1 CDS ureA NC_009567.1 1088883 1089185 R UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma complement(1088883..1089185) Haemophilus influenzae PittGG 5226504 YP_001292486.1 CDS groES NC_009567.1 1089349 1089639 D 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 1089349..1089639 Haemophilus influenzae PittGG 5226505 YP_001292487.1 CDS groEL NC_009567.1 1089659 1091305 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 1089659..1091305 Haemophilus influenzae PittGG 5226506 YP_001292488.1 CDS rplI NC_009567.1 1091478 1091927 R in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 complement(1091478..1091927) Haemophilus influenzae PittGG 5226507 YP_001292489.1 CDS rpsR NC_009567.1 1091944 1092171 R binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 complement(1091944..1092171) Haemophilus influenzae PittGG 5226508 YP_001292490.1 CDS CGSHiGG_05990 NC_009567.1 1092184 1092402 R COG2965 Primosomal replication protein N; primosomal replication protein N complement(1092184..1092402) Haemophilus influenzae PittGG 5226509 YP_001292491.1 CDS rpsF NC_009567.1 1092498 1092875 R binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 complement(1092498..1092875) Haemophilus influenzae PittGG 5226510 YP_001292492.1 CDS infA NC_009567.1 1093075 1093293 R stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 complement(1093075..1093293) Haemophilus influenzae PittGG 5226511 YP_001292493.1 CDS CGSHiGG_06005 NC_009567.1 1093430 1094266 D lipooligosaccharide galactosyltransferase II 1093430..1094266 Haemophilus influenzae PittGG 5226512 YP_001292494.1 CDS CGSHiGG_06010 NC_009567.1 1094297 1094854 D COG3306 Glycosyltransferase involved in LPS biosynthesis; lipooligosaccharide glycosyl transferase G 1094297..1094854 Haemophilus influenzae PittGG 5226513 YP_001292495.1 CDS infA NC_009567.1 1095028 1095348 D COG0438 Glycosyltransferase; translation initiation factor IF-1 1095028..1095348 Haemophilus influenzae PittGG 5226514 YP_001292496.1 CDS ksgA NC_009567.1 1095431 1096294 D catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 1095431..1096294 Haemophilus influenzae PittGG 5226515 YP_001292497.1 CDS apaH NC_009567.1 1097368 1098195 D hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 1097368..1098195 Haemophilus influenzae PittGG 5226516 YP_001292498.1 CDS apaH NC_009567.1 1098205 1098828 D COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases; diadenosine tetraphosphatase 1098205..1098828 Haemophilus influenzae PittGG 5226517 YP_001292499.1 CDS CGSHiGG_06045 NC_009567.1 1098954 1100408 R catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase complement(1098954..1100408) Haemophilus influenzae PittGG 5226518 YP_001292500.1 CDS CGSHiGG_06050 NC_009567.1 1100690 1101223 R COG1943 Transposase and inactivated derivatives; hypothetical protein complement(1100690..1101223) Haemophilus influenzae PittGG 5226519 YP_001292501.1 CDS CGSHiGG_06055 NC_009567.1 1101345 1101506 R COG3759 Predicted membrane protein; hypothetical protein complement(1101345..1101506) Haemophilus influenzae PittGG 5226520 YP_001292502.1 CDS CGSHiGG_06060 NC_009567.1 1101586 1102284 R COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase; 6-phosphogluconate dehydrogenase complement(1101586..1102284) Haemophilus influenzae PittGG 5226521 YP_001292503.1 CDS CGSHiGG_06065 NC_009567.1 1102365 1103849 R catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase complement(1102365..1103849) Haemophilus influenzae PittGG 5226522 YP_001292504.1 CDS CGSHiGG_06070 NC_009567.1 1103925 1104734 R 3'(2'),5'-bisphosphate nucleotidase CysQ complement(1103925..1104734) Haemophilus influenzae PittGG 5226523 YP_001292505.1 CDS CGSHiGG_06075 NC_009567.1 1104739 1105155 R COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase; hypothetical protein complement(1104739..1105155) Haemophilus influenzae PittGG 5226524 YP_001292506.1 CDS CGSHiGG_06080 NC_009567.1 1105208 1107196 R COG1297 Predicted membrane protein; hypothetical protein complement(1105208..1107196) Haemophilus influenzae PittGG 5226525 YP_001292507.1 CDS CGSHiGG_06085 NC_009567.1 1107425 1107790 D COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog); glucose-6-phosphate 1-dehydrogenase 1107425..1107790 Haemophilus influenzae PittGG 5226526 YP_001292508.1 CDS CGSHiGG_06090 NC_009567.1 1107845 1108297 R transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC complement(1107845..1108297) Haemophilus influenzae PittGG 5226527 YP_001292509.1 CDS CGSHiGG_06095 NC_009567.1 1108451 1109443 D catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 1108451..1109443 Haemophilus influenzae PittGG 5226528 YP_001292510.1 CDS CGSHiGG_06100 NC_009567.1 1109508 1110182 R catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase complement(1109508..1110182) Haemophilus influenzae PittGG 5226529 YP_001292511.1 CDS CGSHiGG_06105 NC_009567.1 1110228 1110902 R catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase complement(1110228..1110902) Haemophilus influenzae PittGG 5226530 YP_001292512.1 CDS gyrB NC_009567.1 1111054 1113474 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B complement(1111054..1113474) Haemophilus influenzae PittGG 5226531 YP_001292513.1 CDS gyrB NC_009567.1 1113600 1115912 R COG2183 Transcriptional accessory protein; DNA gyrase subunit B complement(1113600..1115912) Haemophilus influenzae PittGG 5226532 YP_001292514.1 CDS greB NC_009567.1 1116006 1116482 D necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 1116006..1116482 Haemophilus influenzae PittGG 5226533 YP_001292515.1 CDS CGSHiGG_06125 NC_009567.1 1116552 1117169 R negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR complement(1116552..1117169) Haemophilus influenzae PittGG 5226534 YP_001292516.1 CDS CGSHiGG_06130 NC_009567.1 1117169 1118074 R Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR complement(1117169..1118074) Haemophilus influenzae PittGG 5226535 YP_001292517.1 CDS CGSHiGG_06135 NC_009567.1 1118197 1118922 D COG0678 Peroxiredoxin; DNA-binding transcriptional regulator OxyR 1118197..1118922 Haemophilus influenzae PittGG 5226536 YP_001292518.1 CDS CGSHiGG_06140 NC_009567.1 1119010 1119231 R COG2900 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1119010..1119231) Haemophilus influenzae PittGG 5226537 YP_001292519.1 CDS CGSHiGG_06145 NC_009567.1 1119329 1120054 D COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1; FKBP-type peptidyl-prolyl cis-trans isomerase 1119329..1120054 Haemophilus influenzae PittGG 5226538 YP_001292520.1 CDS CGSHiGG_06150 NC_009567.1 1120144 1120809 D COG2964 Uncharacterized protein conserved in bacteria; hypothetical protein 1120144..1120809 Haemophilus influenzae PittGG 5226539 YP_001292521.1 CDS CGSHiGG_06155 NC_009567.1 1120809 1121189 D in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 1120809..1121189 Haemophilus influenzae PittGG 5226540 YP_001292522.1 CDS CGSHiGG_06170 NC_009567.1 1121553 1121840 D COG2168 Uncharacterized conserved protein involved in oxidation of intracellular sulfur; hypothetical protein 1121553..1121840 Haemophilus influenzae PittGG 5226541 YP_001292523.1 CDS CGSHiGG_06185 NC_009567.1 1123861 1124784 D catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 1123861..1124784 Haemophilus influenzae PittGG 5226542 YP_001292524.1 CDS rseB NC_009567.1 1124874 1125821 R periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE complement(1124874..1125821) Haemophilus influenzae PittGG 5226543 YP_001292525.1 CDS CGSHiGG_06195 NC_009567.1 1125901 1126488 R COG3073 Negative regulator of sigma E activity; sigma-E factor negative regulatory protein complement(1125901..1126488) Haemophilus influenzae PittGG 5226544 YP_001292526.1 CDS CGSHiGG_06200 NC_009567.1 1126513 1127082 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE complement(1126513..1127082) Haemophilus influenzae PittGG 5226545 YP_001292527.1 CDS CGSHiGG_06205 NC_009567.1 1127190 1127447 R COG2938 Uncharacterized conserved protein; hypothetical protein complement(1127190..1127447) Haemophilus influenzae PittGG 5226546 YP_001292528.1 CDS mscL NC_009567.1 1127538 1127924 R forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel complement(1127538..1127924) Haemophilus influenzae PittGG 5226547 YP_001292529.1 CDS trkA NC_009567.1 1127997 1129373 R involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component complement(1127997..1129373) Haemophilus influenzae PittGG 5226548 YP_001292530.1 CDS fmt NC_009567.1 1130742 1131698 R modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase complement(1130742..1131698) Haemophilus influenzae PittGG 5226549 YP_001292531.1 CDS def NC_009567.1 1131792 1132301 R cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase complement(1131792..1132301) Haemophilus influenzae PittGG 5226550 YP_001292532.1 CDS CGSHiGG_06240 NC_009567.1 1132396 1132890 R hypothetical protein complement(1132396..1132890) Haemophilus influenzae PittGG 5226551 YP_001292533.1 CDS CGSHiGG_06245 NC_009567.1 1132900 1133361 R hypothetical protein complement(1132900..1133361) Haemophilus influenzae PittGG 5226552 YP_001292534.1 CDS CGSHiGG_06250 NC_009567.1 1133377 1133658 R hypothetical protein complement(1133377..1133658) Haemophilus influenzae PittGG 5226553 YP_001292536.1 CDS CGSHiGG_06260 NC_009567.1 1133771 1133998 R hypothetical protein complement(1133771..1133998) Haemophilus influenzae PittGG 5226555 YP_001292537.1 CDS CGSHiGG_06265 NC_009567.1 1140032 1140568 R hypothetical protein complement(1140032..1140568) Haemophilus influenzae PittGG 5226558 YP_001292538.1 CDS recA NC_009567.1 1141056 1142120 D catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1141056..1142120 Haemophilus influenzae PittGG 5226559 YP_001292539.1 CDS recX NC_009567.1 1142200 1142658 D binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1142200..1142658 Haemophilus influenzae PittGG 5226560 YP_001292540.1 CDS CGSHiGG_06280 NC_009567.1 1142655 1143041 R COG0239 Integral membrane protein possibly involved in chromosome condensation; camphor resistance protein CrcB complement(1142655..1143041) Haemophilus influenzae PittGG 5226561 YP_001292541.1 CDS recX NC_009567.1 1143041 1143859 R COG0561 Predicted hydrolases of the HAD superfamily; recombination regulator RecX complement(1143041..1143859) Haemophilus influenzae PittGG 5226562 YP_001292542.1 CDS CGSHiGG_06290 NC_009567.1 1144263 1145267 D COG0078 Ornithine carbamoyltransferase; ornithine carbamoyltransferase 1144263..1145267 Haemophilus influenzae PittGG 5226563 YP_001292543.1 CDS CGSHiGG_06295 NC_009567.1 1145277 1146209 D reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 1145277..1146209 Haemophilus influenzae PittGG 5226564 YP_001292544.1 CDS CGSHiGG_06300 NC_009567.1 1146319 1147845 D COG1288 Predicted membrane protein; hypothetical protein 1146319..1147845 Haemophilus influenzae PittGG 5226565 YP_001292545.1 CDS CGSHiGG_06305 NC_009567.1 1147935 1148117 D COG1522 Transcriptional regulators; carbamate kinase 1147935..1148117 Haemophilus influenzae PittGG 5226566 YP_001292546.1 CDS CGSHiGG_06310 NC_009567.1 1148239 1148400 D COG1522 Transcriptional regulators; hypothetical protein 1148239..1148400 Haemophilus influenzae PittGG 5226567 YP_001292547.1 CDS CGSHiGG_06315 NC_009567.1 1148447 1148632 D ornithine carbamoyltransferase 1148447..1148632 Haemophilus influenzae PittGG 5226568 YP_001292548.1 CDS CGSHiGG_06320 NC_009567.1 1148931 1149038 D COG0078 Ornithine carbamoyltransferase; hypothetical protein 1148931..1149038 Haemophilus influenzae PittGG 5226569 YP_001292549.1 CDS CGSHiGG_06325 NC_009567.1 1149290 1151452 D COG1982 Arginine/lysine/ornithine decarboxylases; ornithine decarboxylase 1149290..1151452 Haemophilus influenzae PittGG 5226570 YP_001292550.1 CDS potE NC_009567.1 1151559 1152875 D catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter 1151559..1152875 Haemophilus influenzae PittGG 5226571 YP_001292551.1 CDS CGSHiGG_06335 NC_009567.1 1152982 1153398 R COG3086 Positive regulator of sigma E activity; putrescine/proton symporter: putrescine/ornithine antiporter complement(1152982..1153398) Haemophilus influenzae PittGG 5226572 YP_001292552.1 CDS CGSHiGG_06340 NC_009567.1 1153617 1154852 R allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase complement(1153617..1154852) Haemophilus influenzae PittGG 5226573 YP_001292553.1 CDS CGSHiGG_06345 NC_009567.1 1154976 1155680 D alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E 1154976..1155680 Haemophilus influenzae PittGG 5226574 YP_001292554.1 CDS CGSHiGG_06350 NC_009567.1 1155698 1156993 D COG3069 C4-dicarboxylate transporter; C4-dicarboxylate transporter 1155698..1156993 Haemophilus influenzae PittGG 5226575 YP_001292555.1 CDS CGSHiGG_06375 NC_009567.1 1160511 1160903 R COG0789 Predicted transcriptional regulators; HTH-type transcriptional regulator complement(1160511..1160903) Haemophilus influenzae PittGG 5226576 YP_001292556.1 CDS cpdB NC_009567.1 1160928 1161605 R COG1230 Co/Zn/Cd efflux system component; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein complement(1160928..1161605) Haemophilus influenzae PittGG 5226577 YP_001292557.1 CDS CGSHiGG_06385 NC_009567.1 1162109 1163998 D GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 1162109..1163998 Haemophilus influenzae PittGG 5226578 YP_001292558.1 CDS rpsL NC_009567.1 1164180 1164554 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 1164180..1164554 Haemophilus influenzae PittGG 5226579 YP_001292559.1 CDS CGSHiGG_06395 NC_009567.1 1164712 1165182 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 1164712..1165182 Haemophilus influenzae PittGG 5226580 YP_001292560.1 CDS CGSHiGG_06410 NC_009567.1 1167434 1168618 D EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 1167434..1168618 Haemophilus influenzae PittGG 5226581 YP_001292561.1 CDS CGSHiGG_06415 NC_009567.1 1169144 1169422 D COG0038 Chloride channel protein EriC; chloride channel protein 1169144..1169422 Haemophilus influenzae PittGG 5226582 YP_001292562.1 CDS CGSHiGG_06420 NC_009567.1 1169419 1169595 D COG0038 Chloride channel protein EriC; elongation factor G 1169419..1169595 Haemophilus influenzae PittGG 5226583 YP_001292563.1 CDS CGSHiGG_06425 NC_009567.1 1169598 1170581 D COG0042 tRNA-dihydrouridine synthase; tRNA-dihydrouridine synthase A 1169598..1170581 Haemophilus influenzae PittGG 5226584 YP_001292564.1 CDS CGSHiGG_06430 NC_009567.1 1170795 1173998 R hemoglobin-binding protein complement(1170795..1173998) Haemophilus influenzae PittGG 5226585 YP_001292565.1 CDS CGSHiGG_06435 NC_009567.1 1174402 1174572 D COG1629 Outer membrane receptor proteins, mostly Fe transport; hypothetical protein 1174402..1174572 Haemophilus influenzae PittGG 5226586 YP_001292566.1 CDS CGSHiGG_06440 NC_009567.1 1174620 1174910 R COG3691 Uncharacterized protein conserved in bacteria; tRNA-dihydrouridine synthase A complement(1174620..1174910) Haemophilus influenzae PittGG 5226587 YP_001292567.1 CDS CGSHiGG_06445 NC_009567.1 1174932 1175936 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase complement(1174932..1175936) Haemophilus influenzae PittGG 5226588 YP_001292568.1 CDS CGSHiGG_06450 NC_009567.1 1176065 1176682 D HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 1176065..1176682 Haemophilus influenzae PittGG 5226589 YP_001292569.1 CDS CGSHiGG_06455 NC_009567.1 1176705 1178075 D Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1176705..1178075 Haemophilus influenzae PittGG 5226590 YP_001292570.1 CDS rplJ NC_009567.1 1178347 1178838 D binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 1178347..1178838 Haemophilus influenzae PittGG 5226591 YP_001292571.1 CDS rplL NC_009567.1 1178893 1179264 D present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 1178893..1179264 Haemophilus influenzae PittGG 5226592 YP_001292572.1 CDS glmU NC_009567.1 1179426 1180796 D forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 1179426..1180796 Haemophilus influenzae PittGG 5226593 YP_001292573.1 CDS CGSHiGG_06475 NC_009567.1 1180837 1181148 R COG0805 Sec-independent protein secretion pathway component TatC; hypothetical protein complement(1180837..1181148) Haemophilus influenzae PittGG 5226594 YP_001292574.1 CDS CGSHiGG_06495 NC_009567.1 1184355 1185455 R COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit; cytochrome C-like protein complement(1184355..1185455) Haemophilus influenzae PittGG 5226595 YP_001292575.1 CDS glmU NC_009567.1 1185612 1186553 R COG2267 Lysophospholipase; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase complement(1185612..1186553) Haemophilus influenzae PittGG 5226596 YP_001292576.1 CDS CGSHiGG_06505 NC_009567.1 1186607 1187722 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(1186607..1187722) Haemophilus influenzae PittGG 5226597 YP_001292577.1 CDS CGSHiGG_06510 NC_009567.1 1187888 1188604 R COG1285 Uncharacterized membrane protein; hypothetical protein complement(1187888..1188604) Haemophilus influenzae PittGG 5226598 YP_001292578.1 CDS CGSHiGG_06515 NC_009567.1 1188798 1189454 D COG0621 2-methylthioadenine synthetase; 2-methylthioadenine synthetase 1188798..1189454 Haemophilus influenzae PittGG 5226599 YP_001292579.1 CDS CGSHiGG_06520 NC_009567.1 1189518 1190006 R COG2249 Putative NADPH-quinone reductase (modulator of drug activity B); modulator of drug activity B complement(1189518..1190006) Haemophilus influenzae PittGG 5226600 YP_001292580.1 CDS CGSHiGG_06525 NC_009567.1 1190377 1192389 R ATP-dependent DNA helicase complement(1190377..1192389) Haemophilus influenzae PittGG 5226601 YP_001292581.1 CDS CGSHiGG_06530 NC_009567.1 1192395 1192607 R COG0210 Superfamily I DNA and RNA helicases; aspartate-semialdehyde dehydrogenase complement(1192395..1192607) Haemophilus influenzae PittGG 5226602 YP_001292582.1 CDS coaD NC_009567.1 1192604 1193074 R Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase complement(1192604..1193074) Haemophilus influenzae PittGG 5226603 YP_001292583.1 CDS CGSHiGG_06540 NC_009567.1 1193071 1194354 R catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase complement(1193071..1194354) Haemophilus influenzae PittGG 5226604 YP_001292584.1 CDS CGSHiGG_06545 NC_009567.1 1194417 1195181 D COG0463 Glycosyltransferases involved in cell wall biogenesis; UDP-glucose--lipooligosaccharide glucosyltransferase 1194417..1195181 Haemophilus influenzae PittGG 5226605 YP_001292585.1 CDS CGSHiGG_06550 NC_009567.1 1195178 1195834 R DNA-3-methyladenine glycosylase complement(1195178..1195834) Haemophilus influenzae PittGG 5226606 YP_001292586.1 CDS CGSHiGG_06555 NC_009567.1 1195851 1196609 R COG2818 3-methyladenine DNA glycosylase; 3-deoxy-D-manno-octulosonic-acid transferase complement(1195851..1196609) Haemophilus influenzae PittGG 5226607 YP_001292587.1 CDS aroE NC_009567.1 1196621 1197427 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(1196621..1197427) Haemophilus influenzae PittGG 5226608 YP_001292588.1 CDS CGSHiGG_06565 NC_009567.1 1197431 1197982 R COG0009 Putative translation factor (SUA5); hypothetical protein complement(1197431..1197982) Haemophilus influenzae PittGG 5226609 YP_001292589.1 CDS CGSHiGG_06570 NC_009567.1 1197998 1198534 R COG0551 Zn-finger domain associated with topoisomerase type I; hypothetical protein complement(1197998..1198534) Haemophilus influenzae PittGG 5226610 YP_001292590.1 CDS CGSHiGG_06575 NC_009567.1 1198544 1200460 R COG0488 ATPase components of ABC transporters with duplicated ATPase domains; ABC transporter ATP-binding protein complement(1198544..1200460) Haemophilus influenzae PittGG 5226611 YP_001292591.1 CDS CGSHiGG_06580 NC_009567.1 1200621 1200917 R COG1396 Predicted transcriptional regulators; putative HTH-type transcriptional regulator complement(1200621..1200917) Haemophilus influenzae PittGG 5226612 YP_001292592.1 CDS CGSHiGG_06585 NC_009567.1 1200910 1201269 R COG4679 Phage-related protein; hypothetical protein complement(1200910..1201269) Haemophilus influenzae PittGG 5226613 YP_001292593.1 CDS CGSHiGG_06590 NC_009567.1 1201539 1204586 R COG1629 Outer membrane receptor proteins, mostly Fe transport; hemoglobin-binding protein complement(1201539..1204586) Haemophilus influenzae PittGG 5226614 YP_001292594.1 CDS CGSHiGG_06595 NC_009567.1 1205187 1206932 D COG4988 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components; ABC transporter ATP-binding protein 1205187..1206932 Haemophilus influenzae PittGG 5226615 YP_001292595.1 CDS aroE NC_009567.1 1206925 1208583 D COG1132 ABC-type multidrug transport system, ATPase and permease components; shikimate 5-dehydrogenase 1206925..1208583 Haemophilus influenzae PittGG 5226616 YP_001292596.1 CDS glpX NC_009567.1 1209798 1210016 D COG3074 Uncharacterized protein conserved in bacteria; fructose 1,6-bisphosphatase II 1209798..1210016 Haemophilus influenzae PittGG 5226617 YP_001292597.1 CDS CGSHiGG_06620 NC_009567.1 1210113 1210553 D An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 1210113..1210553 Haemophilus influenzae PittGG 5226618 YP_001292598.1 CDS CGSHiGG_06625 NC_009567.1 1210550 1210984 D hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 1210550..1210984 Haemophilus influenzae PittGG 5226619 YP_001292599.1 CDS ispF NC_009567.1 1211289 1211765 R catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase complement(1211289..1211765) Haemophilus influenzae PittGG 5226620 YP_001292600.1 CDS ispD NC_009567.1 1211762 1212439 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(1211762..1212439) Haemophilus influenzae PittGG 5226621 YP_001292601.1 CDS ftsB NC_009567.1 1212439 1212717 R forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB complement(1212439..1212717) Haemophilus influenzae PittGG 5226622 YP_001292603.1 CDS CGSHiGG_06650 NC_009567.1 1212840 1213307 R catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase complement(1212840..1213307) Haemophilus influenzae PittGG 5226624 YP_001292604.1 CDS CGSHiGG_06655 NC_009567.1 1213417 1214871 D COG2195 Di- and tripeptidases; xanthine-guanine phosphoribosyltransferase 1213417..1214871 Haemophilus influenzae PittGG 5226625 YP_001292605.1 CDS xerC NC_009567.1 1215806 1216246 R COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; site-specific tyrosine recombinase XerC complement(1215806..1216246) Haemophilus influenzae PittGG 5226626 YP_001292606.1 CDS tpiA NC_009567.1 1216412 1217203 D Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1216412..1217203 Haemophilus influenzae PittGG 5226627 YP_001292607.1 CDS CGSHiGG_06680 NC_009567.1 1217285 1217602 R COG0607 Rhodanese-related sulfurtransferase; thiosulfate sulfurtransferase GlpE complement(1217285..1217602) Haemophilus influenzae PittGG 5226628 YP_001292608.1 CDS CGSHiGG_06695 NC_009567.1 1218512 1219390 R participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY complement(1218512..1219390) Haemophilus influenzae PittGG 5226629 YP_001292609.1 CDS CGSHiGG_06700 NC_009567.1 1219551 1219691 R COG0583 Transcriptional regulator; hypothetical protein complement(1219551..1219691) Haemophilus influenzae PittGG 5226630 YP_001292610.1 CDS CGSHiGG_06705 NC_009567.1 1220043 1221521 D catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 1220043..1221521 Haemophilus influenzae PittGG 5226631 YP_001292611.1 CDS CGSHiGG_06720 NC_009567.1 1222923 1224221 R sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B complement(1222923..1224221) Haemophilus influenzae PittGG 5226632 YP_001292612.1 CDS glpA NC_009567.1 1224211 1225902 R anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A complement(1224211..1225902) Haemophilus influenzae PittGG 5226633 YP_001292613.1 CDS glpA NC_009567.1 1226195 1227637 D COG2271 Sugar phosphate permease; sn-glycerol-3-phosphate dehydrogenase subunit A 1226195..1227637 Haemophilus influenzae PittGG 5226634 YP_001292614.1 CDS glpQ NC_009567.1 1227741 1228835 D hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase 1227741..1228835 Haemophilus influenzae PittGG 5226635 YP_001292615.1 CDS glpQ NC_009567.1 1229064 1229858 D COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family); glycerophosphodiester phosphodiesterase 1229064..1229858 Haemophilus influenzae PittGG 5226636 YP_001292616.1 CDS glpK NC_009567.1 1229879 1231390 D Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 1229879..1231390 Haemophilus influenzae PittGG 5226637 YP_001292617.1 CDS CGSHiGG_06750 NC_009567.1 1231474 1231941 R catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase complement(1231474..1231941) Haemophilus influenzae PittGG 5226638 YP_001292618.1 CDS CGSHiGG_06755 NC_009567.1 1232008 1232100 D COG0584 Glycerophosphoryl diester phosphodiesterase; glycerophosphodiester phosphodiesterase 1232008..1232100 Haemophilus influenzae PittGG 5226639 YP_001292619.1 CDS CGSHiGG_06760 NC_009567.1 1232226 1233050 D COG2503 Predicted secreted acid phosphatase; lipoprotein E 1232226..1233050 Haemophilus influenzae PittGG 5226640 YP_001292620.1 CDS CGSHiGG_06765 NC_009567.1 1233229 1233912 D COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; hypothetical protein 1233229..1233912 Haemophilus influenzae PittGG 5226641 YP_001292621.1 CDS CGSHiGG_06770 NC_009567.1 1234025 1235002 R COG0248 Exopolyphosphatase; exopolyphosphatase complement(1234025..1235002) Haemophilus influenzae PittGG 5226642 YP_001292622.1 CDS CGSHiGG_06775 NC_009567.1 1235010 1238906 R COG2911 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1235010..1238906) Haemophilus influenzae PittGG 5226643 YP_001292623.1 CDS CGSHiGG_06780 NC_009567.1 1238916 1240685 R COG0729 Outer membrane protein; hypothetical protein complement(1238916..1240685) Haemophilus influenzae PittGG 5226644 YP_001292624.1 CDS glpQ NC_009567.1 1240802 1241374 R COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2; glycerophosphodiester phosphodiesterase complement(1240802..1241374) Haemophilus influenzae PittGG 5226645 YP_001292625.1 CDS CGSHiGG_06790 NC_009567.1 1241454 1241876 R COG3076 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1241454..1241876) Haemophilus influenzae PittGG 5226646 YP_001292626.1 CDS surE NC_009567.1 1243013 1243762 D catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 1243013..1243762 Haemophilus influenzae PittGG 5226647 YP_001292627.1 CDS CGSHiGG_06810 NC_009567.1 1243771 1244349 D COG1238 Predicted membrane protein; lipoprotein B 1243771..1244349 Haemophilus influenzae PittGG 5226648 YP_001292628.1 CDS CGSHiGG_06815 NC_009567.1 1244358 1244543 D COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases; hypothetical protein 1244358..1244543 Haemophilus influenzae PittGG 5226649 YP_001292629.1 CDS CGSHiGG_06820 NC_009567.1 1244567 1245784 D lipoprotein 1244567..1245784 Haemophilus influenzae PittGG 5226650 YP_001292630.1 CDS surE NC_009567.1 1247652 1248884 D COG0814 Amino acid permeases; stationary phase survival protein SurE 1247652..1248884 Haemophilus influenzae PittGG 5226651 YP_001292631.1 CDS CGSHiGG_06865 NC_009567.1 1253284 1255143 D COG3276 Selenocysteine-specific translation elongation factor; selenocysteine-specific elongation factor 1253284..1255143 Haemophilus influenzae PittGG 5226652 YP_001292632.1 CDS CGSHiGG_06870 NC_009567.1 1255162 1256016 D COG0642 Signal transduction histidine kinase; hypothetical protein 1255162..1256016 Haemophilus influenzae PittGG 5226653 YP_001292633.1 CDS CGSHiGG_06875 NC_009567.1 1256070 1259264 R COG1629 Outer membrane receptor proteins, mostly Fe transport; selenocysteine synthase complement(1256070..1259264) Haemophilus influenzae PittGG 5226654 YP_001292634.1 CDS tig NC_009567.1 1259565 1260863 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 1259565..1260863 Haemophilus influenzae PittGG 5226655 YP_001292635.1 CDS clpP NC_009567.1 1260986 1261567 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 1260986..1261567 Haemophilus influenzae PittGG 5226656 YP_001292636.1 CDS clpX NC_009567.1 1261577 1262812 D binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 1261577..1262812 Haemophilus influenzae PittGG 5226657 YP_001292637.1 CDS secE NC_009567.1 1262956 1263372 D forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 1262956..1263372 Haemophilus influenzae PittGG 5226658 YP_001292638.1 CDS nusG NC_009567.1 1263374 1263931 D Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 1263374..1263931 Haemophilus influenzae PittGG 5226659 YP_001292639.1 CDS CGSHiGG_06905 NC_009567.1 1264029 1264781 D COG2853 Surface lipoprotein; lipoprotein 1264029..1264781 Haemophilus influenzae PittGG 5226660 YP_001292640.1 CDS nusG NC_009567.1 1264838 1265227 D COG0251 Putative translation initiation inhibitor, yjgF family; transcription antitermination protein NusG 1264838..1265227 Haemophilus influenzae PittGG 5226661 YP_001292641.1 CDS CGSHiGG_06915 NC_009567.1 1265394 1266245 D putative metalloprotease; heat shock protein HtpX 1265394..1266245 Haemophilus influenzae PittGG 5226662 YP_001292642.1 CDS CGSHiGG_06920 NC_009567.1 1266287 1266526 R TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA complement(1266287..1266526) Haemophilus influenzae PittGG 5226663 YP_001292643.1 CDS CGSHiGG_06925 NC_009567.1 1266629 1267261 D COG1739 Uncharacterized conserved protein; hypothetical protein 1266629..1267261 Haemophilus influenzae PittGG 5226664 YP_001292644.1 CDS CGSHiGG_06930 NC_009567.1 1267264 1268727 D COG0168 Trk-type K+ transport systems, membrane components; Trk system potassium uptake protein TrkH 1267264..1268727 Haemophilus influenzae PittGG 5226665 YP_001292645.1 CDS CGSHiGG_06935 NC_009567.1 1275476 1275742 D phosphate-starvation-inducible protein PsiE 1275476..1275742 Haemophilus influenzae PittGG 5226668 YP_001292646.1 CDS CGSHiGG_06940 NC_009567.1 1275766 1275855 D COG3223 Predicted membrane protein; phosphate-starvation-inducible protein PsiE 1275766..1275855 Haemophilus influenzae PittGG 5226669 YP_001292647.1 CDS CGSHiGG_06945 NC_009567.1 1275923 1277209 R COG3071 Uncharacterized enzyme of heme biosynthesis; heme-biosynthesis protein HemY complement(1275923..1277209) Haemophilus influenzae PittGG 5226670 YP_001292648.1 CDS CGSHiGG_06950 NC_009567.1 1277220 1278431 R COG2959 Uncharacterized enzyme of heme biosynthesis; cell developmental protein SirA complement(1277220..1278431) Haemophilus influenzae PittGG 5226671 YP_001292649.1 CDS cyaA NC_009567.1 1278736 1281267 D catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 1278736..1281267 Haemophilus influenzae PittGG 5226672 YP_001292650.1 CDS cysE NC_009567.1 1282361 1283164 D catalyzes the O-acetylation of serine; serine acetyltransferase 1282361..1283164 Haemophilus influenzae PittGG 5226673 YP_001292651.1 CDS CGSHiGG_06975 NC_009567.1 1283174 1283989 D catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 1283174..1283989 Haemophilus influenzae PittGG 5226674 YP_001292652.1 CDS CGSHiGG_06980 NC_009567.1 1284128 1285513 D COG0471 Di- and tricarboxylate transporters; putative di- and tricarboxylate transporter 1284128..1285513 Haemophilus influenzae PittGG 5226675 YP_001292653.1 CDS CGSHiGG_06985 NC_009567.1 1285651 1286499 R catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(1285651..1286499) Haemophilus influenzae PittGG 5226676 YP_001292654.1 CDS CGSHiGG_07000 NC_009567.1 1288352 1289002 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase complement(1288352..1289002) Haemophilus influenzae PittGG 5226677 YP_001292655.1 CDS CGSHiGG_07005 NC_009567.1 1289022 1289456 R COG4154 Fucose dissimilation pathway protein FucU; L-fuculose phosphate aldolase complement(1289022..1289456) Haemophilus influenzae PittGG 5226681 YP_001292656.1 CDS CGSHiGG_07020 NC_009567.1 1291105 1292721 R COG2407 L-fucose isomerase and related proteins; L-fucose isomerase complement(1291105..1292721) Haemophilus influenzae PittGG 5226682 YP_001292657.1 CDS fucI NC_009567.1 1292962 1293711 R COG1349 Transcriptional regulators of sugar metabolism; L-fucose isomerase complement(1292962..1293711) Haemophilus influenzae PittGG 5226684 YP_001292658.1 CDS CGSHiGG_07040 NC_009567.1 1296684 1297343 D COG0564 Pseudouridylate synthases, 23S RNA-specific; hypothetical protein 1296684..1297343 Haemophilus influenzae PittGG 5226687 YP_001292659.1 CDS CGSHiGG_07045 NC_009567.1 1297370 1297948 D COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid); hypothetical protein 1297370..1297948 Haemophilus influenzae PittGG 5226688 YP_001292660.1 CDS CGSHiGG_07050 NC_009567.1 1297978 1298745 D COG1349 Transcriptional regulators of sugar metabolism; glycerol-3-phosphate regulon repressor 1297978..1298745 Haemophilus influenzae PittGG 5226689 YP_001292661.1 CDS CGSHiGG_07055 NC_009567.1 1299047 1299868 R COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen; putative D-methionine-binding lipoprotein MetQ complement(1299047..1299868) Haemophilus influenzae PittGG 5226690 YP_001292662.1 CDS CGSHiGG_07060 NC_009567.1 1299907 1300596 R COG2011 ABC-type metal ion transport system, permease component; ATP-dependent helicase HepA complement(1299907..1300596) Haemophilus influenzae PittGG 5226691 YP_001292663.1 CDS metN NC_009567.1 1300586 1301623 R part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit complement(1300586..1301623) Haemophilus influenzae PittGG 5226692 YP_001292664.1 CDS CGSHiGG_07070 NC_009567.1 1301800 1302354 D Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 1301800..1302354 Haemophilus influenzae PittGG 5226693 YP_001292665.1 CDS CGSHiGG_07075 NC_009567.1 1308363 1308923 D hypothetical protein 1308363..1308923 Haemophilus influenzae PittGG 5226700 YP_001292666.1 CDS CGSHiGG_07080 NC_009567.1 1308927 1309367 D COG3078 Uncharacterized protein conserved in bacteria; hypothetical protein 1308927..1309367 Haemophilus influenzae PittGG 5226701 YP_001292667.1 CDS CGSHiGG_07085 NC_009567.1 1309429 1310055 R COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; nitrate/nitrite response regulator protein complement(1309429..1310055) Haemophilus influenzae PittGG 5226702 YP_001292668.1 CDS CGSHiGG_07090 NC_009567.1 1310157 1311509 R diaminopimelate decarboxylase complement(1310157..1311509) Haemophilus influenzae PittGG 5226703 YP_001292669.1 CDS CGSHiGG_07095 NC_009567.1 1311557 1311673 R COG0019 Diaminopimelate decarboxylase; hypothetical protein complement(1311557..1311673) Haemophilus influenzae PittGG 5226704 YP_001292670.1 CDS cyaY NC_009567.1 1311770 1312075 D defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 1311770..1312075 Haemophilus influenzae PittGG 5226705 YP_001292671.1 CDS cyaY NC_009567.1 1312077 1313936 D COG0514 Superfamily II DNA helicase; frataxin-like protein 1312077..1313936 Haemophilus influenzae PittGG 5226706 YP_001292672.1 CDS CGSHiGG_07110 NC_009567.1 1314021 1315739 D catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 1314021..1315739 Haemophilus influenzae PittGG 5226707 YP_001292673.1 CDS CGSHiGG_07125 NC_009567.1 1318294 1318785 R COG2132 Putative multicopper oxidases; hypothetical protein complement(1318294..1318785) Haemophilus influenzae PittGG 5226708 YP_001292674.1 CDS CGSHiGG_07130 NC_009567.1 1318791 1319702 R COG2132 Putative multicopper oxidases; hypothetical protein complement(1318791..1319702) Haemophilus influenzae PittGG 5226709 YP_001292675.1 CDS CGSHiGG_07135 NC_009567.1 1319704 1320426 R COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; organic solvent tolerance protein complement(1319704..1320426) Haemophilus influenzae PittGG 5226710 YP_001292676.1 CDS CGSHiGG_07140 NC_009567.1 1320512 1321225 D catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 1320512..1321225 Haemophilus influenzae PittGG 5226711 YP_001292677.1 CDS CGSHiGG_07145 NC_009567.1 1321358 1321453 R COG2908 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1321358..1321453) Haemophilus influenzae PittGG 5226712 YP_001292678.1 CDS CGSHiGG_07150 NC_009567.1 1321455 1322981 R COG0733 Na+-dependent transporters of the SNF family; putative sodium-dependent transporter complement(1321455..1322981) Haemophilus influenzae PittGG 5226713 YP_001292679.1 CDS CGSHiGG_07155 NC_009567.1 1323226 1323852 D UDP-2,3-diacylglucosamine hydrolase 1323226..1323852 Haemophilus influenzae PittGG 5226716 YP_001292680.1 CDS CGSHiGG_07160 NC_009567.1 1323862 1324677 D COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; hypothetical protein 1323862..1324677 Haemophilus influenzae PittGG 5226717 YP_001292681.1 CDS CGSHiGG_07165 NC_009567.1 1324715 1326553 D catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 1324715..1326553 Haemophilus influenzae PittGG 5226718 YP_001292682.1 CDS CGSHiGG_07170 NC_009567.1 1326832 1326960 R hypothetical protein complement(1326832..1326960) Haemophilus influenzae PittGG 5226719 YP_001292683.1 CDS dnaE NC_009567.1 1328210 1331689 R catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha complement(1328210..1331689) Haemophilus influenzae PittGG 5226720 YP_001292684.1 CDS CGSHiGG_07190 NC_009567.1 1331928 1333580 D phosphomannomutase 1331928..1333580 Haemophilus influenzae PittGG 5226721 YP_001292686.1 CDS dnaE NC_009567.1 1333729 1334124 D COG0702 Predicted nucleoside-diphosphate-sugar epimerases; DNA polymerase III subunit alpha 1333729..1334124 Haemophilus influenzae PittGG 5226723 YP_001292687.1 CDS CGSHiGG_07205 NC_009567.1 1334121 1334627 R molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB complement(1334121..1334627) Haemophilus influenzae PittGG 5226724 YP_001292688.1 CDS CGSHiGG_07210 NC_009567.1 1334641 1335087 R COG0607 Rhodanese-related sulfurtransferase; export protein SecB complement(1334641..1335087) Haemophilus influenzae PittGG 5226725 YP_001292689.1 CDS ansB NC_009567.1 1335314 1336363 D catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II 1335314..1336363 Haemophilus influenzae PittGG 5226726 YP_001292690.1 CDS CGSHiGG_07220 NC_009567.1 1336520 1337842 D functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 1336520..1337842 Haemophilus influenzae PittGG 5226727 YP_001292691.1 CDS CGSHiGG_07235 NC_009567.1 1339460 1341892 R PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase complement(1339460..1341892) Haemophilus influenzae PittGG 5226728 YP_001292692.1 CDS CGSHiGG_07240 NC_009567.1 1342147 1342770 D Represses a number of genes involved in the response to DNA damage; LexA repressor 1342147..1342770 Haemophilus influenzae PittGG 5226729 YP_001292693.1 CDS dapF NC_009567.1 1342913 1343737 D involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 1342913..1343737 Haemophilus influenzae PittGG 5226730 YP_001292694.1 CDS tpx NC_009567.1 1343957 1344454 R antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase complement(1343957..1344454) Haemophilus influenzae PittGG 5226731 YP_001292695.1 CDS CGSHiGG_07255 NC_009567.1 1345102 1348995 D catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 1345102..1348995 Haemophilus influenzae PittGG 5226732 YP_001292696.1 CDS CGSHiGG_07260 NC_009567.1 1349191 1349496 D COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain; hypothetical protein 1349191..1349496 Haemophilus influenzae PittGG 5226733 YP_001292697.1 CDS CGSHiGG_07265 NC_009567.1 1349510 1350253 D COG3306 Glycosyltransferase involved in LPS biosynthesis; UDP-glucose--lipooligosaccharide glucosyltransferase 1349510..1350253 Haemophilus influenzae PittGG 5226734 YP_001292698.1 CDS CGSHiGG_07270 NC_009567.1 1350314 1351156 R COG2861 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1350314..1351156) Haemophilus influenzae PittGG 5226735 YP_001292699.1 CDS CGSHiGG_07275 NC_009567.1 1351156 1352385 R COG4942 Membrane-bound metallopeptidase; membrane-bound metallopeptidase complement(1351156..1352385) Haemophilus influenzae PittGG 5226736 YP_001292700.1 CDS CGSHiGG_07280 NC_009567.1 1352561 1353244 D 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 1352561..1353244 Haemophilus influenzae PittGG 5226737 YP_001292701.1 CDS rpmE NC_009567.1 1353322 1353534 R RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 complement(1353322..1353534) Haemophilus influenzae PittGG 5226738 YP_001292702.1 CDS rpmE NC_009567.1 1353711 1354847 D COG1194 A/G-specific DNA glycosylase; 50S ribosomal protein L31 1353711..1354847 Haemophilus influenzae PittGG 5226739 YP_001292703.1 CDS CGSHiGG_07295 NC_009567.1 1354825 1355097 D COG2924 Fe-S cluster protector protein; hypothetical protein 1354825..1355097 Haemophilus influenzae PittGG 5226740 YP_001292704.1 CDS mltC NC_009567.1 1355112 1356185 D Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 1355112..1356185 Haemophilus influenzae PittGG 5226741 YP_001292705.1 CDS mltC NC_009567.1 1356797 1357477 R COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases; murein transglycosylase C complement(1356797..1357477) Haemophilus influenzae PittGG 5226742 YP_001292706.1 CDS CGSHiGG_07310 NC_009567.1 1357474 1358697 R catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase complement(1357474..1358697) Haemophilus influenzae PittGG 5226743 YP_001292707.1 CDS ribB NC_009567.1 1358958 1359605 D DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase 1358958..1359605 Haemophilus influenzae PittGG 5226744 YP_001292708.1 CDS CGSHiGG_07320 NC_009567.1 1359637 1360350 D COG3306 Glycosyltransferase involved in LPS biosynthesis; lipooligosaccharide biosynthesis protein 1359637..1360350 Haemophilus influenzae PittGG 5226745 YP_001292709.1 CDS CGSHiGG_07325 NC_009567.1 1360518 1361000 R COG0219 Predicted rRNA methylase (SpoU class); putative RNA methyltransferase complement(1360518..1361000) Haemophilus influenzae PittGG 5226746 YP_001292710.1 CDS CGSHiGG_07330 NC_009567.1 1361011 1361592 R COG0742 N6-adenine-specific methylase; hypothetical protein complement(1361011..1361592) Haemophilus influenzae PittGG 5226747 YP_001292711.1 CDS CGSHiGG_07335 NC_009567.1 1361689 1362891 D COG0552 Signal recognition particle GTPase; cell division protein FtsY 1361689..1362891 Haemophilus influenzae PittGG 5226748 YP_001292712.1 CDS ribB NC_009567.1 1362910 1363566 D COG2884 Predicted ATPase involved in cell division; 3,4-dihydroxy-2-butanone 4-phosphate synthase 1362910..1363566 Haemophilus influenzae PittGG 5226749 YP_001292713.1 CDS ftsX NC_009567.1 1363576 1364508 D putative ABC transporter, membrane protein; cell division protein FtsX 1363576..1364508 Haemophilus influenzae PittGG 5226750 YP_001292714.1 CDS CGSHiGG_07350 NC_009567.1 1364603 1365784 R COG0183 Acetyl-CoA acetyltransferase; acetyl-CoA acetyltransferase complement(1364603..1365784) Haemophilus influenzae PittGG 5226751 YP_001292715.1 CDS ftsX NC_009567.1 1367146 1367811 R COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit; membrane component of ABC transporter FtsEX complement(1367146..1367811) Haemophilus influenzae PittGG 5226752 YP_001292716.1 CDS CGSHiGG_07370 NC_009567.1 1367822 1368475 R COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit; acetyl-CoA:acetoacetyl-CoA transferase subunit alpha complement(1367822..1368475) Haemophilus influenzae PittGG 5226753 YP_001292717.1 CDS CGSHiGG_07375 NC_009567.1 1368722 1369627 D COG0583 Transcriptional regulator; putative HTH-type transcriptional regulator 1368722..1369627 Haemophilus influenzae PittGG 5226754 YP_001292718.1 CDS CGSHiGG_07380 NC_009567.1 1369863 1370174 D COG0051 Ribosomal protein S10; acetyl-CoA:acetoacetyl-CoA transferase subunit alpha 1369863..1370174 Haemophilus influenzae PittGG 5226755 YP_001292719.1 CDS rplC NC_009567.1 1370191 1370817 D binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 1370191..1370817 Haemophilus influenzae PittGG 5226756 YP_001292720.1 CDS rplD NC_009567.1 1370833 1371435 D L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 1370833..1371435 Haemophilus influenzae PittGG 5226757 YP_001292721.1 CDS rplW NC_009567.1 1371432 1371731 D binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 1371432..1371731 Haemophilus influenzae PittGG 5226758 YP_001292722.1 CDS rplB NC_009567.1 1371749 1372570 D one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 1371749..1372570 Haemophilus influenzae PittGG 5226759 YP_001292723.1 CDS rpsS NC_009567.1 1372596 1372871 D protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 1372596..1372871 Haemophilus influenzae PittGG 5226760 YP_001292724.1 CDS rplV NC_009567.1 1372883 1373215 D binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 1372883..1373215 Haemophilus influenzae PittGG 5226761 YP_001292725.1 CDS rpsC NC_009567.1 1373233 1373940 D forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 1373233..1373940 Haemophilus influenzae PittGG 5226762 YP_001292726.1 CDS rplP NC_009567.1 1373954 1374364 D located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 1373954..1374364 Haemophilus influenzae PittGG 5226763 YP_001292727.1 CDS CGSHiGG_07425 NC_009567.1 1374364 1374555 D one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 1374364..1374555 Haemophilus influenzae PittGG 5226764 YP_001292728.1 CDS rpsQ NC_009567.1 1374555 1374812 D primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 1374555..1374812 Haemophilus influenzae PittGG 5226765 YP_001292729.1 CDS rpsQ NC_009567.1 1375040 1375825 D COG0186 Ribosomal protein S17; 30S ribosomal protein S17 1375040..1375825 Haemophilus influenzae PittGG 5226766 YP_001292730.1 CDS rplN NC_009567.1 1376105 1376476 D binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 1376105..1376476 Haemophilus influenzae PittGG 5226770 YP_001292731.1 CDS rplX NC_009567.1 1376487 1376798 D assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 1376487..1376798 Haemophilus influenzae PittGG 5226771 YP_001292732.1 CDS rplE NC_009567.1 1376816 1377355 D part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 1376816..1377355 Haemophilus influenzae PittGG 5226772 YP_001292733.1 CDS rpsN NC_009567.1 1377367 1377672 D located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 1377367..1377672 Haemophilus influenzae PittGG 5226773 YP_001292734.1 CDS rpsH NC_009567.1 1377709 1378101 D binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 1377709..1378101 Haemophilus influenzae PittGG 5226774 YP_001292735.1 CDS rplF NC_009567.1 1378117 1378650 D ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 1378117..1378650 Haemophilus influenzae PittGG 5226775 YP_001292736.1 CDS rplR NC_009567.1 1378664 1379017 D binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 1378664..1379017 Haemophilus influenzae PittGG 5226776 YP_001292737.1 CDS rpsE NC_009567.1 1379032 1379532 D located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 1379032..1379532 Haemophilus influenzae PittGG 5226777 YP_001292738.1 CDS rpmD NC_009567.1 1379539 1379718 D L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 1379539..1379718 Haemophilus influenzae PittGG 5226778 YP_001292739.1 CDS rplO NC_009567.1 1379722 1380156 D late assembly protein; 50S ribosomal protein L15 1379722..1380156 Haemophilus influenzae PittGG 5226779 YP_001292740.1 CDS secY NC_009567.1 1380164 1381489 D forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 1380164..1381489 Haemophilus influenzae PittGG 5226780 YP_001292741.1 CDS rpsM NC_009567.1 1381771 1382127 D located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 1381771..1382127 Haemophilus influenzae PittGG 5226781 YP_001292742.1 CDS rpsM NC_009567.1 1382394 1382531 D located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 1382394..1382531 Haemophilus influenzae PittGG 5226782 YP_001292743.1 CDS rpsD NC_009567.1 1382559 1383179 D primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 1382559..1383179 Haemophilus influenzae PittGG 5226783 YP_001292744.1 CDS CGSHiGG_07510 NC_009567.1 1383211 1384197 D catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 1383211..1384197 Haemophilus influenzae PittGG 5226784 YP_001292745.1 CDS rplQ NC_009567.1 1384238 1384624 D is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 1384238..1384624 Haemophilus influenzae PittGG 5226785 YP_001292746.1 CDS CGSHiGG_07520 NC_009567.1 1384751 1385017 R COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases; cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase complement(1384751..1385017) Haemophilus influenzae PittGG 5226786 YP_001292747.1 CDS rplQ NC_009567.1 1385213 1386022 D COG0730 Predicted permeases; 50S ribosomal protein L17 1385213..1386022 Haemophilus influenzae PittGG 5226787 YP_001292748.1 CDS CGSHiGG_07530 NC_009567.1 1386054 1387247 R catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase complement(1386054..1387247) Haemophilus influenzae PittGG 5226788 YP_001292749.1 CDS frr NC_009567.1 1387356 1387913 R Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor complement(1387356..1387913) Haemophilus influenzae PittGG 5226789 YP_001292750.1 CDS CGSHiGG_07540 NC_009567.1 1388062 1389678 R PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase complement(1388062..1389678) Haemophilus influenzae PittGG 5226790 YP_001292751.1 CDS hslO NC_009567.1 1389851 1390732 R becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin complement(1389851..1390732) Haemophilus influenzae PittGG 5226791 YP_001292752.1 CDS CGSHiGG_07550 NC_009567.1 1390877 1392250 R catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase complement(1390877..1392250) Haemophilus influenzae PittGG 5226792 YP_001292753.1 CDS CGSHiGG_07555 NC_009567.1 1392385 1393272 R COG1210 UDP-glucose pyrophosphorylase; argininosuccinate lyase complement(1392385..1393272) Haemophilus influenzae PittGG 5226793 YP_001292754.1 CDS CGSHiGG_07560 NC_009567.1 1393294 1393485 R affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator complement(1393294..1393485) Haemophilus influenzae PittGG 5226794 YP_001292755.1 CDS alaS NC_009567.1 1393563 1396187 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(1393563..1396187) Haemophilus influenzae PittGG 5226795 YP_001292756.1 CDS CGSHiGG_07570 NC_009567.1 1396375 1396800 R COG0589 Universal stress protein UspA and related nucleotide-binding proteins; universal stress protein A complement(1396375..1396800) Haemophilus influenzae PittGG 5226796 YP_001292757.1 CDS CGSHiGG_07585 NC_009567.1 1398205 1398753 R the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein complement(1398205..1398753) Haemophilus influenzae PittGG 5226797 YP_001292758.1 CDS galM NC_009567.1 1398924 1399946 R catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase complement(1398924..1399946) Haemophilus influenzae PittGG 5226798 YP_001292759.1 CDS CGSHiGG_07595 NC_009567.1 1399956 1401110 R catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase complement(1399956..1401110) Haemophilus influenzae PittGG 5226799 YP_001292760.1 CDS CGSHiGG_07600 NC_009567.1 1401187 1402236 R catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase complement(1401187..1402236) Haemophilus influenzae PittGG 5226800 YP_001292761.1 CDS CGSHiGG_07605 NC_009567.1 1402445 1403446 D COG1609 Transcriptional regulators; galactose operon repressor 1402445..1403446 Haemophilus influenzae PittGG 5226801 YP_001292762.1 CDS CGSHiGG_07610 NC_009567.1 1403621 1404616 D COG1879 ABC-type sugar transport system, periplasmic component; galactose-1-phosphate uridylyltransferase 1403621..1404616 Haemophilus influenzae PittGG 5226802 YP_001292763.1 CDS CGSHiGG_07615 NC_009567.1 1404681 1406201 D with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein 1404681..1406201 Haemophilus influenzae PittGG 5226803 YP_001292764.1 CDS mglC NC_009567.1 1406219 1407229 D ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane component 1406219..1407229 Haemophilus influenzae PittGG 5226804 YP_001292765.1 CDS mglC NC_009567.1 1407375 1408109 D COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; beta-methylgalactoside transporter inner membrane component 1407375..1408109 Haemophilus influenzae PittGG 5226805 YP_001292766.1 CDS CGSHiGG_07630 NC_009567.1 1408115 1408672 D Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 1408115..1408672 Haemophilus influenzae PittGG 5227430 YP_001292767.1 CDS CGSHiGG_07645 NC_009567.1 1409152 1409448 D unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; YciI-like protein 1409152..1409448 Haemophilus influenzae PittGG 5227431 YP_001292768.1 CDS CGSHiGG_07650 NC_009567.1 1409464 1411248 D COG1196 Chromosome segregation ATPases; intracellular septation protein A 1409464..1411248 Haemophilus influenzae PittGG 5227432 YP_001292769.1 CDS CGSHiGG_07655 NC_009567.1 1411286 1411591 D When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 1411286..1411591 Haemophilus influenzae PittGG 5227433 YP_001292770.1 CDS mtgA NC_009567.1 1411631 1412317 D glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase 1411631..1412317 Haemophilus influenzae PittGG 5227434 YP_001292771.1 CDS CGSHiGG_07665 NC_009567.1 1412422 1412766 R in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D complement(1412422..1412766) Haemophilus influenzae PittGG 5227435 YP_001292772.1 CDS CGSHiGG_07670 NC_009567.1 1412779 1413189 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C complement(1412779..1413189) Haemophilus influenzae PittGG 5227436 YP_001292773.1 CDS CGSHiGG_07675 NC_009567.1 1413214 1413969 R COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; fumarate reductase iron-sulfur subunit complement(1413214..1413969) Haemophilus influenzae PittGG 5227437 YP_001292774.1 CDS CGSHiGG_07690 NC_009567.1 1415971 1416942 D lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 1415971..1416942 Haemophilus influenzae PittGG 5227438 YP_001292775.1 CDS CGSHiGG_07695 NC_009567.1 1417208 1417891 R COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; response regulator complement(1417208..1417891) Haemophilus influenzae PittGG 5227439 YP_001292776.1 CDS CGSHiGG_07700 NC_009567.1 1417945 1418358 R COG2913 Small protein A (tmRNA-binding); small protein A complement(1417945..1418358) Haemophilus influenzae PittGG 5227440 YP_001292777.1 CDS CGSHiGG_07705 NC_009567.1 1418424 1419440 R COG3081 Nucleoid-associated protein; nucleoid-associated protein NdpA complement(1418424..1419440) Haemophilus influenzae PittGG 5227441 YP_001292778.1 CDS CGSHiGG_07710 NC_009567.1 1419566 1419784 D COG3082 Uncharacterized protein conserved in bacteria; hypothetical protein 1419566..1419784 Haemophilus influenzae PittGG 5227442 YP_001292779.1 CDS CGSHiGG_07715 NC_009567.1 1419786 1421549 D COG3083 Predicted hydrolase of alkaline phosphatase superfamily; nucleoid-associated protein NdpA 1419786..1421549 Haemophilus influenzae PittGG 5227443 YP_001292780.1 CDS CGSHiGG_07720 NC_009567.1 1421751 1422734 D COG0402 Cytosine deaminase and related metal-dependent hydrolases; hypothetical protein 1421751..1422734 Haemophilus influenzae PittGG 5227444 YP_001292781.1 CDS mobA NC_009567.1 1422873 1423397 R in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA complement(1422873..1423397) Haemophilus influenzae PittGG 5227445 YP_001292782.1 CDS CGSHiGG_07730 NC_009567.1 1423513 1423779 D COG3084 Uncharacterized protein conserved in bacteria; hypothetical protein 1423513..1423779 Haemophilus influenzae PittGG 5227446 YP_001292783.1 CDS mobA NC_009567.1 1423790 1424407 D COG0526 Thiol-disulfide isomerase and thioredoxins; molybdopterin-guanine dinucleotide biosynthesis protein A 1423790..1424407 Haemophilus influenzae PittGG 5227447 YP_001292784.1 CDS CGSHiGG_07740 NC_009567.1 1424469 1424762 D COG3085 Uncharacterized protein conserved in bacteria; hypothetical protein 1424469..1424762 Haemophilus influenzae PittGG 5227448 YP_001292785.1 CDS CGSHiGG_07755 NC_009567.1 1426021 1426794 D COG0500 SAM-dependent methyltransferases; SAM-dependent methyltransferase 1426021..1426794 Haemophilus influenzae PittGG 5227449 YP_001292786.1 CDS CGSHiGG_07760 NC_009567.1 1426788 1427222 D positive regulator of sigma E 1426788..1427222 Haemophilus influenzae PittGG 5227450 YP_001292788.1 CDS CGSHiGG_07770 NC_009567.1 1427647 1428162 D COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein; molybdopterin-guanine dinucleotide biosynthesis protein B 1427647..1428162 Haemophilus influenzae PittGG 5227452 YP_001292789.1 CDS CGSHiGG_07775 NC_009567.1 1428159 1429550 D COG0477 Permeases of the major facilitator superfamily; hypothetical protein 1428159..1429550 Haemophilus influenzae PittGG 5227453 YP_001292790.1 CDS CGSHiGG_07790 NC_009567.1 1431516 1432277 D COG0748 Putative heme iron utilization protein; putative heme iron utilization protein 1431516..1432277 Haemophilus influenzae PittGG 5227454 YP_001292791.1 CDS CGSHiGG_07795 NC_009567.1 1432629 1432757 R COG3681 Uncharacterized conserved protein; hypothetical protein complement(1432629..1432757) Haemophilus influenzae PittGG 5227455 YP_001292792.1 CDS CGSHiGG_07800 NC_009567.1 1432772 1435564 R has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I complement(1432772..1435564) Haemophilus influenzae PittGG 5227456 YP_001292793.1 CDS CGSHiGG_07805 NC_009567.1 1435713 1436015 D COG3027 Uncharacterized protein conserved in bacteria; hypothetical protein 1435713..1436015 Haemophilus influenzae PittGG 5227457 YP_001292794.1 CDS CGSHiGG_07810 NC_009567.1 1436333 1436896 D COG0212 5-formyltetrahydrofolate cyclo-ligase; hypothetical protein 1436333..1436896 Haemophilus influenzae PittGG 5227458 YP_001292795.1 CDS CGSHiGG_07815 NC_009567.1 1437024 1439594 D COG0542 ATPases with chaperone activity, ATP-binding subunit; DNA polymerase I 1437024..1439594 Haemophilus influenzae PittGG 5227459 YP_001292796.1 CDS CGSHiGG_07820 NC_009567.1 1439631 1440371 R Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase complement(1439631..1440371) Haemophilus influenzae PittGG 5227460 YP_001292797.1 CDS CGSHiGG_07825 NC_009567.1 1440427 1442775 R COG0557 Exoribonuclease R; 23S rRNA (guanosine-2'-O-)-methyltransferase complement(1440427..1442775) Haemophilus influenzae PittGG 5227461 YP_001292798.1 CDS CGSHiGG_07830 NC_009567.1 1442967 1443674 R COG1738 Uncharacterized conserved protein; hypothetical protein complement(1442967..1443674) Haemophilus influenzae PittGG 5227462 YP_001292799.1 CDS CGSHiGG_07835 NC_009567.1 1443867 1444499 D catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 1443867..1444499 Haemophilus influenzae PittGG 5227463 YP_001292800.1 CDS CGSHiGG_07840 NC_009567.1 1444587 1446437 R GTP-binding protein TypA/ BipA complement(1444587..1446437) Haemophilus influenzae PittGG 5227464 YP_001292801.1 CDS CGSHiGG_07845 NC_009567.1 1446564 1447568 R COG1217 Predicted membrane GTPase involved in stress response; CMP-neu5Ac--lipooligosaccharide alpha 2-3 sialyltransferase complement(1446564..1447568) Haemophilus influenzae PittGG 5227465 YP_001292802.1 CDS CGSHiGG_07850 NC_009567.1 1447725 1449137 D COG0174 Glutamine synthetase; glutamine synthetase 1447725..1449137 Haemophilus influenzae PittGG 5227466 YP_001292803.1 CDS CGSHiGG_07855 NC_009567.1 1449614 1450117 D COG3765 Chain length determinant protein; hypothetical protein 1449614..1450117 Haemophilus influenzae PittGG 5227467 YP_001292804.1 CDS CGSHiGG_07875 NC_009567.1 1451559 1452305 D COG0463 Glycosyltransferases involved in cell wall biogenesis; hypothetical protein 1451559..1452305 Haemophilus influenzae PittGG 5227468 YP_001292805.1 CDS CGSHiGG_07880 NC_009567.1 1452310 1453194 D COG1216 Predicted glycosyltransferases; hypothetical protein 1452310..1453194 Haemophilus influenzae PittGG 5227469 YP_001292806.1 CDS CGSHiGG_07885 NC_009567.1 1453673 1454239 D putative polysaccharide polymerase 1453673..1454239 Haemophilus influenzae PittGG 5227470 YP_001292807.1 CDS CGSHiGG_07890 NC_009567.1 1454381 1455259 D COG3307 Lipid A core - O-antigen ligase and related enzymes; N-acetylneuraminic acid synthase-like protein 1454381..1455259 Haemophilus influenzae PittGG 5227471 YP_001292808.1 CDS CGSHiGG_07895 NC_009567.1 1455252 1456670 D COG2148 Sugar transferases involved in lipopolysaccharide synthesis; undecaprenyl-phosphate galactosephosphotransferase 1455252..1456670 Haemophilus influenzae PittGG 5227472 YP_001292809.1 CDS CGSHiGG_07900 NC_009567.1 1456742 1457746 D COG1088 dTDP-D-glucose 4,6-dehydratase; dTDP-glucose 46-dehydratase 1456742..1457746 Haemophilus influenzae PittGG 5227473 YP_001292810.1 CDS CGSHiGG_07915 NC_009567.1 1459156 1460460 D catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase B 1459156..1460460 Haemophilus influenzae PittGG 5227474 YP_001292811.1 CDS ndk NC_009567.1 1460470 1460892 D catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1460470..1460892 Haemophilus influenzae PittGG 5227475 YP_001292812.1 CDS obgE NC_009567.1 1460962 1462173 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(1460962..1462173) Haemophilus influenzae PittGG 5227476 YP_001292813.1 CDS rpmA NC_009567.1 1463201 1463458 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(1463201..1463458) Haemophilus influenzae PittGG 5227477 YP_001292814.1 CDS rplU NC_009567.1 1463479 1463790 R COG0261 Ribosomal protein L21; 50S ribosomal protein L21 complement(1463479..1463790) Haemophilus influenzae PittGG 5227478 YP_001292815.1 CDS CGSHiGG_07950 NC_009567.1 1464021 1464992 D COG0142 Geranylgeranyl pyrophosphate synthase; octaprenyl-diphosphate synthase 1464021..1464992 Haemophilus influenzae PittGG 5227479 YP_001292816.1 CDS CGSHiGG_07965 NC_009567.1 1465838 1467208 R COG1115 Na+/alanine symporter; putative Na+/alanine symporter complement(1465838..1467208) Haemophilus influenzae PittGG 5227480 YP_001292817.1 CDS CGSHiGG_07970 NC_009567.1 1467607 1468317 R COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; two-component response regulator complement(1467607..1468317) Haemophilus influenzae PittGG 5227481 YP_001292818.1 CDS dipZ NC_009567.1 1468507 1470246 D two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein 1468507..1470246 Haemophilus influenzae PittGG 5227482 YP_001292819.1 CDS CGSHiGG_07980 NC_009567.1 1470358 1470762 D COG2259 Predicted membrane protein; hypothetical protein 1470358..1470762 Haemophilus influenzae PittGG 5227483 YP_001292820.1 CDS purH NC_009567.1 1470950 1472548 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1470950..1472548 Haemophilus influenzae PittGG 5227484 YP_001292821.1 CDS CGSHiGG_07990 NC_009567.1 1472733 1474022 D catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 1472733..1474022 Haemophilus influenzae PittGG 5227485 YP_001292822.1 CDS glyA NC_009567.1 1474146 1475411 D catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 1474146..1475411 Haemophilus influenzae PittGG 5227486 YP_001292823.1 CDS coaE NC_009567.1 1475482 1476102 D catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 1475482..1476102 Haemophilus influenzae PittGG 5227487 YP_001292824.1 CDS CGSHiGG_08005 NC_009567.1 1476095 1476301 D COG3024 Uncharacterized protein conserved in bacteria; zinc-binding protein 1476095..1476301 Haemophilus influenzae PittGG 5227488 YP_001292825.1 CDS CGSHiGG_08010 NC_009567.1 1476419 1477666 D enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB 1476419..1477666 Haemophilus influenzae PittGG 5227489 YP_001292827.1 CDS CGSHiGG_08020 NC_009567.1 1477908 1478471 D COG1309 Transcriptional regulator; transcriptional repressor 1477908..1478471 Haemophilus influenzae PittGG 5227491 YP_001292828.1 CDS CGSHiGG_08025 NC_009567.1 1478503 1479699 D COG0845 Membrane-fusion protein; putative membrane-fusion protein 1478503..1479699 Haemophilus influenzae PittGG 5227492 YP_001292829.1 CDS CGSHiGG_08030 NC_009567.1 1479717 1482794 D COG0841 Cation/multidrug efflux pump; acriflavine resistance protein 1479717..1482794 Haemophilus influenzae PittGG 5227493 YP_001292830.1 CDS CGSHiGG_08035 NC_009567.1 1483029 1483799 D COG3087 Cell division protein; cell division protein 1483029..1483799 Haemophilus influenzae PittGG 5227494 YP_001292831.1 CDS CGSHiGG_08050 NC_009567.1 1485355 1486527 R COG1566 Multidrug resistance efflux pump; multidrug resistance protein A complement(1485355..1486527) Haemophilus influenzae PittGG 5227495 YP_001292832.1 CDS CGSHiGG_08055 NC_009567.1 1486709 1487191 R COG0262 Dihydrofolate reductase; dihydrofolate reductase complement(1486709..1487191) Haemophilus influenzae PittGG 5227496 YP_001292833.1 CDS CGSHiGG_08060 NC_009567.1 1487292 1488398 D catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 1487292..1488398 Haemophilus influenzae PittGG 5227497 YP_001292834.1 CDS CGSHiGG_08065 NC_009567.1 1488479 1489069 D hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 1488479..1489069 Haemophilus influenzae PittGG 5227498 YP_001292835.1 CDS CGSHiGG_08070 NC_009567.1 1489069 1489863 D COG0730 Predicted permeases; hypothetical protein 1489069..1489863 Haemophilus influenzae PittGG 5227499 YP_001292836.1 CDS thyA NC_009567.1 1490687 1491538 D ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 1490687..1491538 Haemophilus influenzae PittGG 5227500 YP_001292837.1 CDS CGSHiGG_08090 NC_009567.1 1491538 1491915 D COG0590 Cytosine/adenosine deaminases; hypothetical protein 1491538..1491915 Haemophilus influenzae PittGG 5227501 YP_001292838.1 CDS CGSHiGG_08095 NC_009567.1 1492087 1492401 R hypothetical protein complement(1492087..1492401) Haemophilus influenzae PittGG 5227502 YP_001292839.1 CDS CGSHiGG_08100 NC_009567.1 1492481 1492783 D COG4701 Uncharacterized protein conserved in bacteria; hypothetical protein 1492481..1492783 Haemophilus influenzae PittGG 5227503 YP_001292840.1 CDS CGSHiGG_08105 NC_009567.1 1492908 1495613 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1492908..1495613 Haemophilus influenzae PittGG 5227504 YP_001292841.1 CDS CGSHiGG_08110 NC_009567.1 1495678 1496088 D COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; mutator protein MutT 1495678..1496088 Haemophilus influenzae PittGG 5227505 YP_001292842.1 CDS CGSHiGG_08115 NC_009567.1 1496197 1498053 D COG0475 Kef-type K+ transport systems, membrane components; glutathione-regulated potassium-efflux system protein 1496197..1498053 Haemophilus influenzae PittGG 5227506 YP_001292843.1 CDS CGSHiGG_08120 NC_009567.1 1498173 1498937 D COG0500 SAM-dependent methyltransferases; hypothetical protein 1498173..1498937 Haemophilus influenzae PittGG 5227507 YP_001292844.1 CDS rpsB NC_009567.1 1499115 1499837 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 1499115..1499837 Haemophilus influenzae PittGG 5227508 YP_001292845.1 CDS tsf NC_009567.1 1499971 1500822 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 1499971..1500822 Haemophilus influenzae PittGG 5227509 YP_001292846.1 CDS lpxD NC_009567.1 1500991 1502016 R adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase complement(1500991..1502016) Haemophilus influenzae PittGG 5227510 YP_001292847.1 CDS CGSHiGG_08140 NC_009567.1 1502029 1502622 R COG2825 Outer membrane protein; Outer membrane protein 26 complement(1502029..1502622) Haemophilus influenzae PittGG 5227511 YP_001292848.1 CDS CGSHiGG_08145 NC_009567.1 1502730 1505123 R COG4775 Outer membrane protein/protective antigen OMA87; protective surface antigen D15 complement(1502730..1505123) Haemophilus influenzae PittGG 5227512 YP_001292849.1 CDS CGSHiGG_08150 NC_009567.1 1505143 1506474 R COG0750 Predicted membrane-associated Zn-dependent proteases 1; hypothetical protein complement(1505143..1506474) Haemophilus influenzae PittGG 5227513 YP_001292850.1 CDS CGSHiGG_08155 NC_009567.1 1506484 1507350 R phosphatidate cytidylyltransferase complement(1506484..1507350) Haemophilus influenzae PittGG 5227514 YP_001292851.1 CDS leuS NC_009567.1 1508337 1510922 D leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 1508337..1510922 Haemophilus influenzae PittGG 5227515 YP_001292852.1 CDS CGSHiGG_08175 NC_009567.1 1511017 1511520 D COG2980 Rare lipoprotein B; rare lipoprotein B 1511017..1511520 Haemophilus influenzae PittGG 5227516 YP_001292853.1 CDS holA NC_009567.1 1511520 1512554 D required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 1511520..1512554 Haemophilus influenzae PittGG 5227517 YP_001292854.1 CDS glyS NC_009567.1 1512788 1514854 R glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(1512788..1514854) Haemophilus influenzae PittGG 5227518 YP_001292855.1 CDS rpmA NC_009567.1 1515192 1515410 R COG2852 Uncharacterized protein conserved in bacteria; 50S ribosomal protein L27 complement(1515192..1515410) Haemophilus influenzae PittGG 5227519 YP_001292856.1 CDS CGSHiGG_08195 NC_009567.1 1515441 1515701 R hypothetical protein complement(1515441..1515701) Haemophilus influenzae PittGG 5227520 YP_001292857.1 CDS glyQ NC_009567.1 1515760 1516668 R glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(1515760..1516668) Haemophilus influenzae PittGG 5227521 YP_001292858.1 CDS CGSHiGG_08205 NC_009567.1 1516932 1518458 D hypothetical protein 1516932..1518458 Haemophilus influenzae PittGG 5227522 YP_001292859.1 CDS CGSHiGG_08210 NC_009567.1 1518675 1519856 R hypothetical protein complement(1518675..1519856) Haemophilus influenzae PittGG 5227523 YP_001292860.1 CDS CGSHiGG_08215 NC_009567.1 1519857 1520438 R hypothetical protein complement(1519857..1520438) Haemophilus influenzae PittGG 5227524 YP_001292861.1 CDS CGSHiGG_08220 NC_009567.1 1520451 1520870 R hypothetical protein complement(1520451..1520870) Haemophilus influenzae PittGG 5227525 YP_001292862.1 CDS eno NC_009567.1 1520954 1522264 R enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase complement(1520954..1522264) Haemophilus influenzae PittGG 5227526 YP_001292863.1 CDS CGSHiGG_08230 NC_009567.1 1522385 1523590 R hypothetical protein complement(1522385..1523590) Haemophilus influenzae PittGG 5227527 YP_001292864.1 CDS CGSHiGG_08235 NC_009567.1 1523587 1524741 R hypothetical protein complement(1523587..1524741) Haemophilus influenzae PittGG 5227528 YP_001292865.1 CDS CGSHiGG_08240 NC_009567.1 1524738 1525265 R hypothetical protein complement(1524738..1525265) Haemophilus influenzae PittGG 5227529 YP_001292866.1 CDS CGSHiGG_08245 NC_009567.1 1525265 1527172 R hypothetical protein complement(1525265..1527172) Haemophilus influenzae PittGG 5227530 YP_001292867.1 CDS CGSHiGG_08250 NC_009567.1 1527280 1528083 R hypothetical protein complement(1527280..1528083) Haemophilus influenzae PittGG 5227531 YP_001292868.1 CDS CGSHiGG_08255 NC_009567.1 1528283 1528795 D hypothetical protein 1528283..1528795 Haemophilus influenzae PittGG 5227532 YP_001292869.1 CDS CGSHiGG_08260 NC_009567.1 1528795 1529511 D hypothetical protein 1528795..1529511 Haemophilus influenzae PittGG 5227533 YP_001292870.1 CDS CGSHiGG_08265 NC_009567.1 1529526 1530209 D hypothetical protein 1529526..1530209 Haemophilus influenzae PittGG 5227534 YP_001292871.1 CDS CGSHiGG_08270 NC_009567.1 1530202 1530489 D hypothetical protein 1530202..1530489 Haemophilus influenzae PittGG 5227535 YP_001292872.1 CDS CGSHiGG_08275 NC_009567.1 1530535 1533915 D exodeoxyribonuclease V subunit gamma 1530535..1533915 Haemophilus influenzae PittGG 5227536 YP_001292873.1 CDS CGSHiGG_08280 NC_009567.1 1533970 1534332 D hypothetical protein 1533970..1534332 Haemophilus influenzae PittGG 5227537 YP_001292874.1 CDS CGSHiGG_08285 NC_009567.1 1534423 1535541 D hypothetical protein 1534423..1535541 Haemophilus influenzae PittGG 5227538 YP_001292875.1 CDS CGSHiGG_08290 NC_009567.1 1535542 1536564 D hypothetical protein 1535542..1536564 Haemophilus influenzae PittGG 5227539 YP_001292876.1 CDS CGSHiGG_08295 NC_009567.1 1536638 1537453 R Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase complement(1536638..1537453) Haemophilus influenzae PittGG 5227540 YP_001292877.1 CDS CGSHiGG_08300 NC_009567.1 1537685 1539220 R hypothetical protein complement(1537685..1539220) Haemophilus influenzae PittGG 5227541 YP_001292878.1 CDS CGSHiGG_08305 NC_009567.1 1539240 1539638 R hypothetical protein complement(1539240..1539638) Haemophilus influenzae PittGG 5227542 YP_001292879.1 CDS CGSHiGG_08310 NC_009567.1 1539638 1539871 R hypothetical protein complement(1539638..1539871) Haemophilus influenzae PittGG 5227543 YP_001292880.1 CDS CGSHiGG_08315 NC_009567.1 1540018 1541382 R catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde; diaminobutyrate--2-oxoglutarate aminotransferase complement(1540018..1541382) Haemophilus influenzae PittGG 5227544 YP_001292881.1 CDS rpmG NC_009567.1 1541729 1541899 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 complement(1541729..1541899) Haemophilus influenzae PittGG 5227545 YP_001292882.1 CDS rpmB NC_009567.1 1541911 1542147 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(1541911..1542147) Haemophilus influenzae PittGG 5227546 YP_001292883.1 CDS CGSHiGG_08340 NC_009567.1 1543190 1544392 D catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 1543190..1544392 Haemophilus influenzae PittGG 5227547 YP_001292884.1 CDS dut NC_009567.1 1544440 1544895 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 1544440..1544895 Haemophilus influenzae PittGG 5227548 YP_001292885.1 CDS slmA NC_009567.1 1544899 1545555 D FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 1544899..1545555 Haemophilus influenzae PittGG 5227549 YP_001292886.1 CDS slmA NC_009567.1 1545577 1545678 D COG3089 Uncharacterized protein conserved in bacteria; nucleoid occlusion protein 1545577..1545678 Haemophilus influenzae PittGG 5227550 YP_001292887.1 CDS CGSHiGG_08360 NC_009567.1 1545813 1546487 D complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 1545813..1546487 Haemophilus influenzae PittGG 5227551 YP_001292888.1 CDS rumB NC_009567.1 1546852 1548030 R RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase complement(1546852..1548030) Haemophilus influenzae PittGG 5227552 YP_001292889.1 CDS CGSHiGG_08370 NC_009567.1 1548027 1549070 R hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase complement(1548027..1549070) Haemophilus influenzae PittGG 5227553 YP_001292890.1 CDS CGSHiGG_08375 NC_009567.1 1549083 1549433 R COG5633 Predicted periplasmic lipoprotein; hypothetical protein complement(1549083..1549433) Haemophilus influenzae PittGG 5227554 YP_001292891.1 CDS CGSHiGG_08380 NC_009567.1 1549433 1549783 R COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases; beta-hexosaminidase complement(1549433..1549783) Haemophilus influenzae PittGG 5227555 YP_001292892.1 CDS ileS NC_009567.1 1549901 1552726 R IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase complement(1549901..1552726) Haemophilus influenzae PittGG 5227556 YP_001292893.1 CDS CGSHiGG_08390 NC_009567.1 1552754 1553680 R catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase complement(1552754..1553680) Haemophilus influenzae PittGG 5227557 YP_001292894.1 CDS CGSHiGG_08395 NC_009567.1 1553727 1555301 R bifunctional riboflavin kinase/FMN adenylyltransferase complement(1553727..1555301) Haemophilus influenzae PittGG 5227558 YP_001292895.1 CDS CGSHiGG_08400 NC_009567.1 1555354 1555635 R COG0728 Uncharacterized membrane protein, putative virulence factor; hypothetical protein complement(1555354..1555635) Haemophilus influenzae PittGG 5227559 YP_001292896.1 CDS CGSHiGG_08405 NC_009567.1 1555647 1555832 D 30S ribosomal protein S20 1555647..1555832 Haemophilus influenzae PittGG 5227560 YP_001292897.1 CDS CGSHiGG_08410 NC_009567.1 1555905 1556471 R hypothetical protein complement(1555905..1556471) Haemophilus influenzae PittGG 5227561 YP_001292898.1 CDS rpsT NC_009567.1 1556497 1556601 D COG0268 Ribosomal protein S20; 30S ribosomal protein S20 1556497..1556601 Haemophilus influenzae PittGG 5227562 YP_001292899.1 CDS CGSHiGG_08420 NC_009567.1 1556617 1557474 D catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 1556617..1557474 Haemophilus influenzae PittGG 5227563 YP_001292900.1 CDS CGSHiGG_08425 NC_009567.1 1557543 1558532 D catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 1557543..1558532 Haemophilus influenzae PittGG 5227564 YP_001292901.1 CDS CGSHiGG_08430 NC_009567.1 1558589 1559038 D catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 1558589..1559038 Haemophilus influenzae PittGG 5227565 YP_001292902.1 CDS CGSHiGG_08435 NC_009567.1 1559191 1559658 D composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 1559191..1559658 Haemophilus influenzae PittGG 5227566 YP_001292903.1 CDS CGSHiGG_08440 NC_009567.1 1559835 1561181 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 1559835..1561181 Haemophilus influenzae PittGG 5227567 YP_001292904.1 CDS CGSHiGG_08445 NC_009567.1 1561384 1561641 D COG3924 Predicted membrane protein; acetyl-CoA carboxylase biotin carboxylase subunit 1561384..1561641 Haemophilus influenzae PittGG 5227568 YP_001292905.1 CDS panF NC_009567.1 1561638 1563092 D mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 1561638..1563092 Haemophilus influenzae PittGG 5227569 YP_001292906.1 CDS prmA NC_009567.1 1564120 1565007 D methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 1564120..1565007 Haemophilus influenzae PittGG 5227570 YP_001292907.1 CDS prmA NC_009567.1 1565154 1566134 D COG0042 tRNA-dihydrouridine synthase; ribosomal protein L11 methyltransferase 1565154..1566134 Haemophilus influenzae PittGG 5227571 YP_001292908.1 CDS fis NC_009567.1 1566128 1566427 D Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 1566128..1566427 Haemophilus influenzae PittGG 5227572 YP_001292909.1 CDS smpB NC_009567.1 1566522 1567007 R binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein complement(1566522..1567007) Haemophilus influenzae PittGG 5227573 YP_001292910.1 CDS CGSHiGG_08485 NC_009567.1 1567246 1568163 R catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase complement(1567246..1568163) Haemophilus influenzae PittGG 5227574 YP_001292911.1 CDS CGSHiGG_08490 NC_009567.1 1568308 1568889 R COG0205 6-phosphofructokinase; hypothetical protein complement(1568308..1568889) Haemophilus influenzae PittGG 5227575 YP_001292912.1 CDS CGSHiGG_08495 NC_009567.1 1568882 1569658 R COG3022 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1568882..1569658) Haemophilus influenzae PittGG 5227576 YP_001292913.1 CDS CGSHiGG_08500 NC_009567.1 1569711 1570832 R COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake; hypothetical protein complement(1569711..1570832) Haemophilus influenzae PittGG 5227577 YP_001292914.1 CDS CGSHiGG_08525 NC_009567.1 1574323 1575690 D dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 1574323..1575690 Haemophilus influenzae PittGG 5227578 YP_001292915.1 CDS leuD NC_009567.1 1575701 1576303 D catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 1575701..1576303 Haemophilus influenzae PittGG 5227579 YP_001292916.1 CDS CGSHiGG_08555 NC_009567.1 1583192 1584292 R binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta complement(1583192..1584292) Haemophilus influenzae PittGG 5227580 YP_001292917.1 CDS dnaA NC_009567.1 1584551 1585915 R binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein complement(1584551..1585915) Haemophilus influenzae PittGG 5227581 YP_001292918.1 CDS CGSHiGG_08575 NC_009567.1 1588871 1588996 D hypothetical protein 1588871..1588996 Haemophilus influenzae PittGG 5227582 YP_001292919.1 CDS CGSHiGG_08580 NC_009567.1 1589382 1590818 R transferrin-binding protein 2 complement(1589382..1590818) Haemophilus influenzae PittGG 5227583 YP_001292920.1 CDS dnaA NC_009567.1 1590914 1592359 D COG1629 Outer membrane receptor proteins, mostly Fe transport; chromosomal replication initiation protein 1590914..1592359 Haemophilus influenzae PittGG 5227584 YP_001292921.1 CDS rpmH NC_009567.1 1592535 1592669 D in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 1592535..1592669 Haemophilus influenzae PittGG 5227585 YP_001292922.1 CDS rnpA NC_009567.1 1592682 1593041 D protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 1592682..1593041 Haemophilus influenzae PittGG 5227586 YP_001292923.1 CDS CGSHiGG_08600 NC_009567.1 1593005 1593265 D COG0759 Uncharacterized conserved protein; hypothetical protein 1593005..1593265 Haemophilus influenzae PittGG 5227587 YP_001292924.1 CDS trmE NC_009567.1 1595136 1596494 D in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 1595136..1596494 Haemophilus influenzae PittGG 5227588 YP_001292925.1 CDS CGSHiGG_08620 NC_009567.1 1596682 1598550 D COG0760 Parvulin-like peptidyl-prolyl isomerase; peptidyl-prolyl cis-trans isomerase D 1596682..1598550 Haemophilus influenzae PittGG 5227589 YP_001292926.1 CDS trmE NC_009567.1 1598641 1600197 D COG2194 Predicted membrane-associated, metal-dependent hydrolase; tRNA modification GTPase TrmE 1598641..1600197 Haemophilus influenzae PittGG 5227590 YP_001292927.1 CDS lspA NC_009567.1 1600267 1600782 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 1600267..1600782 Haemophilus influenzae PittGG 5227591 YP_001292928.1 CDS ispH NC_009567.1 1600779 1601723 D catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1600779..1601723 Haemophilus influenzae PittGG 5227592 YP_001292929.1 CDS CGSHiGG_08640 NC_009567.1 1601892 1602239 D COG1555 DNA uptake protein and related DNA-binding proteins; hypothetical protein 1601892..1602239 Haemophilus influenzae PittGG 5227593 YP_001292930.1 CDS CGSHiGG_08655 NC_009567.1 1603214 1604119 D 3-hydroxyisobutyrate dehydrogenase 1603214..1604119 Haemophilus influenzae PittGG 5227594 YP_001292931.1 CDS CGSHiGG_08660 NC_009567.1 1604122 1604193 D COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases; hypothetical protein 1604122..1604193 Haemophilus influenzae PittGG 5227595 YP_001292932.1 CDS ispH NC_009567.1 1604205 1605362 D COG3395 Uncharacterized protein conserved in bacteria; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1604205..1605362 Haemophilus influenzae PittGG 5227596 YP_001292933.1 CDS CGSHiGG_08670 NC_009567.1 1605359 1605991 D COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; putative aldolase 1605359..1605991 Haemophilus influenzae PittGG 5227597 YP_001292934.1 CDS CGSHiGG_08675 NC_009567.1 1605994 1606770 D COG3622 Hydroxypyruvate isomerase; hypothetical protein 1605994..1606770 Haemophilus influenzae PittGG 5227598 YP_001292935.1 CDS CGSHiGG_08680 NC_009567.1 1606865 1608217 D COG2610 H+/gluconate symporter and related permeases; gluconate transport protein GntT 1606865..1608217 Haemophilus influenzae PittGG 5227599 YP_001292936.1 CDS CGSHiGG_08685 NC_009567.1 1608275 1609609 D COG4099 Predicted peptidase; hypothetical protein 1608275..1609609 Haemophilus influenzae PittGG 5227600 YP_001292937.1 CDS CGSHiGG_08690 NC_009567.1 1609621 1610307 D COG1878 Predicted metal-dependent hydrolase; hypothetical protein 1609621..1610307 Haemophilus influenzae PittGG 5227601 YP_001292938.1 CDS CGSHiGG_08695 NC_009567.1 1610373 1611086 D COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family); glycerol uptake facilitator protein 1610373..1611086 Haemophilus influenzae PittGG 5227602 YP_001292939.1 CDS CGSHiGG_08700 NC_009567.1 1611154 1611288 R COG3676 Transposase and inactivated derivatives; transposase complement(1611154..1611288) Haemophilus influenzae PittGG 5227603 YP_001292940.1 CDS CGSHiGG_08705 NC_009567.1 1611859 1612857 D COG4143 ABC-type thiamine transport system, periplasmic component; putative aldolase 1611859..1612857 Haemophilus influenzae PittGG 5227604 YP_001292941.1 CDS CGSHiGG_08720 NC_009567.1 1614463 1615110 D COG3840 ABC-type thiamine transport system, ATPase component; thiamin ABC transporter ATP-binding protein 1614463..1615110 Haemophilus influenzae PittGG 5227605 YP_001292942.1 CDS thiP NC_009567.1 1615223 1616221 D COG0502 Biotin synthase and related enzymes; thiamin transporter membrane protein 1615223..1616221 Haemophilus influenzae PittGG 5227606 YP_001292943.1 CDS CGSHiGG_08730 NC_009567.1 1616348 1618345 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(1616348..1618345) Haemophilus influenzae PittGG 5227607 YP_001292944.1 CDS ulaD NC_009567.1 1618474 1619151 R catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase complement(1618474..1619151) Haemophilus influenzae PittGG 5227608 YP_001292945.1 CDS CGSHiGG_08750 NC_009567.1 1619891 1620751 R L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; putative L-xylulose 5-phosphate 3-epimerase complement(1619891..1620751) Haemophilus influenzae PittGG 5227609 YP_001292946.1 CDS CGSHiGG_08755 NC_009567.1 1620765 1622222 R COG1070 Sugar (pentulose and hexulose) kinases; L-xylulose kinase complement(1620765..1622222) Haemophilus influenzae PittGG 5227610 YP_001292947.1 CDS CGSHiGG_08760 NC_009567.1 1622281 1623267 R COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component; hypothetical protein complement(1622281..1623267) Haemophilus influenzae PittGG 5227611 YP_001292948.1 CDS CGSHiGG_08765 NC_009567.1 1623298 1624575 R COG1593 TRAP-type C4-dicarboxylate transport system, large permease component; hypothetical protein complement(1623298..1624575) Haemophilus influenzae PittGG 5227612 YP_001292949.1 CDS CGSHiGG_08770 NC_009567.1 1624572 1625054 R COG3090 TRAP-type C4-dicarboxylate transport system, small permease component; hypothetical protein complement(1624572..1625054) Haemophilus influenzae PittGG 5227613 YP_001292950.1 CDS CGSHiGG_08775 NC_009567.1 1625129 1626127 R NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; 2,3-diketo-L-gulonate reductase complement(1625129..1626127) Haemophilus influenzae PittGG 5227614 YP_001292951.1 CDS araD NC_009567.1 1626321 1627109 D COG1414 Transcriptional regulator; L-ribulose-5-phosphate 4-epimerase 1626321..1627109 Haemophilus influenzae PittGG 5227615 YP_001292952.1 CDS serB NC_009567.1 1627259 1628203 D catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 1627259..1628203 Haemophilus influenzae PittGG 5227616 YP_001292953.1 CDS CGSHiGG_08790 NC_009567.1 1628221 1628712 D putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; putative nucleotide-binding protein 1628221..1628712 Haemophilus influenzae PittGG 5227617 YP_001292954.1 CDS CGSHiGG_08795 NC_009567.1 1629008 1629955 D responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 1629008..1629955 Haemophilus influenzae PittGG 5227618 YP_001292955.1 CDS CGSHiGG_08800 NC_009567.1 1629955 1630500 D COG0762 Predicted integral membrane protein; integral membrane protein 1629955..1630500 Haemophilus influenzae PittGG 5227619 YP_001292956.1 CDS CGSHiGG_08805 NC_009567.1 1630681 1631517 R COG0121 Predicted glutamine amidotransferase; hypothetical protein complement(1630681..1631517) Haemophilus influenzae PittGG 5227620 YP_001292957.1 CDS CGSHiGG_08810 NC_009567.1 1631957 1633147 D hypothetical protein 1631957..1633147 Haemophilus influenzae PittGG 5227621 YP_001292958.1 CDS CGSHiGG_08815 NC_009567.1 1633398 1633538 D hypothetical protein 1633398..1633538 Haemophilus influenzae PittGG 5227622 YP_001292959.1 CDS CGSHiGG_08820 NC_009567.1 1633686 1633790 R COG1373 Predicted ATPase (AAA+ superfamily); hypothetical protein complement(1633686..1633790) Haemophilus influenzae PittGG 5227623 YP_001292960.1 CDS CGSHiGG_08845 NC_009567.1 1637590 1637691 R COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain; hypothetical protein complement(1637590..1637691) Haemophilus influenzae PittGG 5227624 YP_001292961.1 CDS metH NC_009567.1 1637798 1638298 R COG1145 Ferredoxin; B12-dependent methionine synthase complement(1637798..1638298) Haemophilus influenzae PittGG 5227625 YP_001292962.1 CDS CGSHiGG_08855 NC_009567.1 1638298 1638909 R binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD complement(1638298..1638909) Haemophilus influenzae PittGG 5227626 YP_001292963.1 CDS CGSHiGG_08860 NC_009567.1 1639021 1639860 R COG3302 DMSO reductase anchor subunit; anaerobic dimethyl sulfoxide reductase chain C complement(1639021..1639860) Haemophilus influenzae PittGG 5227627 YP_001292964.1 CDS CGSHiGG_08865 NC_009567.1 1639862 1640479 R COG0437 Fe-S-cluster-containing hydrogenase components 1; anaerobic dimethyl sulfoxide reductase chain B complement(1639862..1640479) Haemophilus influenzae PittGG 5227628 YP_001292965.1 CDS CGSHiGG_08870 NC_009567.1 1640490 1640639 R COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; anaerobic dimethyl sulfoxide reductase chain A complement(1640490..1640639) Haemophilus influenzae PittGG 5227629 YP_001292966.1 CDS CGSHiGG_08875 NC_009567.1 1640630 1642909 R COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; anaerobic dimethyl sulfoxide reductase chain A complement(1640630..1642909) Haemophilus influenzae PittGG 5227630 YP_001292967.1 CDS CGSHiGG_08880 NC_009567.1 1643162 1644271 D hypothetical protein 1643162..1644271 Haemophilus influenzae PittGG 5227631 YP_001292968.1 CDS CGSHiGG_08885 NC_009567.1 1644246 1644608 D COG1305 Transglutaminase-like enzymes, putative cysteine proteases; hypothetical protein 1644246..1644608 Haemophilus influenzae PittGG 5227632 YP_001292969.1 CDS CGSHiGG_08890 NC_009567.1 1644617 1644895 D COG2608 Copper chaperone; hypothetical protein 1644617..1644895 Haemophilus influenzae PittGG 5227633 YP_001292970.1 CDS CGSHiGG_08895 NC_009567.1 1645019 1646863 R COG1132 ABC-type multidrug transport system, ATPase and permease components; ABC transporter ATP-binding protein complement(1645019..1646863) Haemophilus influenzae PittGG 5227634 YP_001292971.1 CDS CGSHiGG_08900 NC_009567.1 1646942 1647838 R COG2207 AraC-type DNA-binding domain-containing proteins; transcriptional regulator AraC family protein complement(1646942..1647838) Haemophilus influenzae PittGG 5227635 YP_001292972.1 CDS CGSHiGG_08905 NC_009567.1 1647950 1648291 D COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit; hypothetical protein 1647950..1648291 Haemophilus influenzae PittGG 5227636 YP_001292973.1 CDS CGSHiGG_08910 NC_009567.1 1648391 1648990 R COG3421 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1648391..1648990) Haemophilus influenzae PittGG 5227637 YP_001292974.1 CDS CGSHiGG_08915 NC_009567.1 1649002 1651158 R COG3421 Uncharacterized protein conserved in bacteria; putative type III restriction-modification system HindVIP enzyme res complement(1649002..1651158) Haemophilus influenzae PittGG 5227638 YP_001292975.1 CDS CGSHiGG_08920 NC_009567.1 1651148 1653322 R COG2189 Adenine specific DNA methylase Mod; twin-argninine leader-binding protein DmsD complement(1651148..1653322) Haemophilus influenzae PittGG 5227639 YP_001292976.1 CDS rnhB NC_009567.1 1653536 1654129 R RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII complement(1653536..1654129) Haemophilus influenzae PittGG 5227640 YP_001292977.1 CDS lpxB NC_009567.1 1654122 1655294 R catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase complement(1654122..1655294) Haemophilus influenzae PittGG 5227641 YP_001292978.1 CDS fabZ NC_009567.1 1656165 1656611 R in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase complement(1656165..1656611) Haemophilus influenzae PittGG 5227642 YP_001292979.1 CDS CGSHiGG_08950 NC_009567.1 1656697 1658256 R COG2194 Predicted membrane-associated, metal-dependent hydrolase; UDP-N-acetylglucosamine acyltransferase complement(1656697..1658256) Haemophilus influenzae PittGG 5227643 YP_001292980.1 CDS pyrH NC_009567.1 1658387 1659100 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 1658387..1659100 Haemophilus influenzae PittGG 5227644 YP_001292981.1 CDS pyrH NC_009567.1 1660300 1660977 R uridylate kinase complement(1660300..1660977) Haemophilus influenzae PittGG 5227645 YP_001292982.1 CDS CGSHiGG_08975 NC_009567.1 1660974 1661624 R part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit complement(1660974..1661624) Haemophilus influenzae PittGG 5227646 YP_001292983.1 CDS nrfA NC_009567.1 1661701 1663227 R catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 complement(1661701..1663227) Haemophilus influenzae PittGG 5227647 YP_001292984.1 CDS CGSHiGG_08985 NC_009567.1 1663479 1667390 R involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA complement(1663479..1667390) Haemophilus influenzae PittGG 5227648 YP_001292985.1 CDS CGSHiGG_08990 NC_009567.1 1667387 1667761 R COG2363 Uncharacterized small membrane protein; hypothetical protein complement(1667387..1667761) Haemophilus influenzae PittGG 5227649 YP_001292986.1 CDS CGSHiGG_08995 NC_009567.1 1667762 1668214 R hypothetical protein complement(1667762..1668214) Haemophilus influenzae PittGG 5227650 YP_001292987.1 CDS CGSHiGG_09000 NC_009567.1 1668370 1668468 R COG2707 Predicted membrane protein; hypothetical protein complement(1668370..1668468) Haemophilus influenzae PittGG 5227651 YP_001292988.1 CDS CGSHiGG_09005 NC_009567.1 1668480 1669616 R COG1294 Cytochrome bd-type quinol oxidase, subunit 2; putative cytochrome oxidase subunit II complement(1668480..1669616) Haemophilus influenzae PittGG 5227652 YP_001292989.1 CDS CGSHiGG_09010 NC_009567.1 1669631 1671196 R ATP-dependent RNA helicase HrpA complement(1669631..1671196) Haemophilus influenzae PittGG 5227653 YP_001292990.1 CDS CGSHiGG_09015 NC_009567.1 1671641 1671820 R COG1271 Cytochrome bd-type quinol oxidase, subunit 1; hypothetical protein complement(1671641..1671820) Haemophilus influenzae PittGG 5227654 YP_001292991.1 CDS pyrG NC_009567.1 1671849 1673486 D CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 1671849..1673486 Haemophilus influenzae PittGG 5227655 YP_001292992.1 CDS CGSHiGG_09025 NC_009567.1 1673854 1674312 R COG3201 Nicotinamide mononucleotide transporter; nicotinamide riboside transporter complement(1673854..1674312) Haemophilus influenzae PittGG 5227656 YP_001292993.1 CDS CGSHiGG_09030 NC_009567.1 1674494 1675261 R COG1126 ABC-type polar amino acid transport system, ATPase component; putative amino-acid ABC transporter ATP-binding protein complement(1674494..1675261) Haemophilus influenzae PittGG 5227657 YP_001292994.1 CDS CGSHiGG_09035 NC_009567.1 1675271 1675987 R COG0765 ABC-type amino acid transport system, permease component; ABC-type amino acid transport system permease complement(1675271..1675987) Haemophilus influenzae PittGG 5227658 YP_001292995.1 CDS CGSHiGG_09040 NC_009567.1 1675971 1676744 R COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; CTP synthetase complement(1675971..1676744) Haemophilus influenzae PittGG 5227659 YP_001292996.1 CDS CGSHiGG_09045 NC_009567.1 1677045 1678319 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(1677045..1678319) Haemophilus influenzae PittGG 5227660 YP_001292997.1 CDS CGSHiGG_09050 NC_009567.1 1678329 1678586 R COG5007 Predicted transcriptional regulator, BolA superfamily; BolA superfamily transcriptional regulator protein complement(1678329..1678586) Haemophilus influenzae PittGG 5227661 YP_001292998.1 CDS CGSHiGG_09055 NC_009567.1 1678607 1678924 R COG3113 Predicted NTP binding protein (contains STAS domain); NTP binding protein, contains STAS domain complement(1678607..1678924) Haemophilus influenzae PittGG 5227662 YP_001292999.1 CDS CGSHiGG_09060 NC_009567.1 1678935 1679579 R COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component; ABC transporter complement(1678935..1679579) Haemophilus influenzae PittGG 5227663 YP_001293000.1 CDS CGSHiGG_09065 NC_009567.1 1679612 1680112 R COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component; ABC transporter periplasmic protein complement(1679612..1680112) Haemophilus influenzae PittGG 5227664 YP_001293001.1 CDS CGSHiGG_09070 NC_009567.1 1680122 1680907 R COG0767 ABC-type transport system involved in resistance to organic solvents, permease component; ABC transporter permease complement(1680122..1680907) Haemophilus influenzae PittGG 5227665 YP_001293002.1 CDS CGSHiGG_09075 NC_009567.1 1680904 1681698 R COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component; ABC transporter ATPase complement(1680904..1681698) Haemophilus influenzae PittGG 5227666 YP_001293003.1 CDS CGSHiGG_09080 NC_009567.1 1682117 1682752 R COG0605 Superoxide dismutase; superoxide dismutase (Mn) complement(1682117..1682752) Haemophilus influenzae PittGG 5227667 YP_001293004.1 CDS CGSHiGG_09085 NC_009567.1 1683001 1683639 D ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 1683001..1683639 Haemophilus influenzae PittGG 5227668 YP_001293005.1 CDS CGSHiGG_09090 NC_009567.1 1683644 1684309 D COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component; heme exporter protein B 1683644..1684309 Haemophilus influenzae PittGG 5227669 YP_001293006.1 CDS CGSHiGG_09095 NC_009567.1 1684370 1685110 D COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component; heme exporter protein C 1684370..1685110 Haemophilus influenzae PittGG 5227670 YP_001293007.1 CDS CGSHiGG_09100 NC_009567.1 1685152 1685355 D COG3114 Heme exporter protein D; heme exporter protein D 1685152..1685355 Haemophilus influenzae PittGG 5227671 YP_001293008.1 CDS CGSHiGG_09105 NC_009567.1 1685352 1685873 D CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 1685352..1685873 Haemophilus influenzae PittGG 5227672 YP_001293009.1 CDS CGSHiGG_09120 NC_009567.1 1687930 1688475 D COG0526 Thiol-disulfide isomerase and thioredoxins; thiol-disulfide interchange protein 1687930..1688475 Haemophilus influenzae PittGG 5227673 YP_001293010.1 CDS CGSHiGG_09125 NC_009567.1 1688475 1688936 D COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes; cytochrome C-type biogenesis protein 1688475..1688936 Haemophilus influenzae PittGG 5227674 YP_001293011.1 CDS CGSHiGG_09130 NC_009567.1 1688937 1689854 D TPR repeat-containing protein 1688937..1689854 Haemophilus influenzae PittGG 5227675 YP_001293012.1 CDS CGSHiGG_09135 NC_009567.1 1689975 1690115 D hypothetical protein 1689975..1690115 Haemophilus influenzae PittGG 5227676 YP_001293013.1 CDS CGSHiGG_09140 NC_009567.1 1690289 1690474 D hypothetical protein 1690289..1690474 Haemophilus influenzae PittGG 5227677 YP_001293014.1 CDS CGSHiGG_09145 NC_009567.1 1690485 1690784 D COG4235 Cytochrome c biogenesis factor; hypothetical protein 1690485..1690784 Haemophilus influenzae PittGG 5227678 YP_001293015.1 CDS ligA NC_009567.1 1690789 1692801 R this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA complement(1690789..1692801) Haemophilus influenzae PittGG 5227679 YP_001293016.1 CDS CGSHiGG_09155 NC_009567.1 1692913 1693899 R interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA complement(1692913..1693899) Haemophilus influenzae PittGG 5227680 YP_001293017.1 CDS CGSHiGG_09160 NC_009567.1 1694052 1694870 D putative role in sulfur assimilation; putative sulfate transport protein CysZ 1694052..1694870 Haemophilus influenzae PittGG 5227681 YP_001293018.1 CDS CGSHiGG_09165 NC_009567.1 1694969 1695919 D COG0031 Cysteine synthase; cysteine synthase 1694969..1695919 Haemophilus influenzae PittGG 5227682 YP_001293019.1 CDS CGSHiGG_09170 NC_009567.1 1696167 1697390 D COG0477 Permeases of the major facilitator superfamily; transporter protein 1696167..1697390 Haemophilus influenzae PittGG 5227683 YP_001293020.1 CDS CGSHiGG_09175 NC_009567.1 1697590 1698540 R COG0859 ADP-heptose:LPS heptosyltransferase; ADP-heptose-LPS heptosyltransferase II complement(1697590..1698540) Haemophilus influenzae PittGG 5227684 YP_001293021.1 CDS CGSHiGG_09180 NC_009567.1 1698616 1699779 R COG1609 Transcriptional regulators; xylose operon regulatory protein complement(1698616..1699779) Haemophilus influenzae PittGG 5227685 YP_001293022.1 CDS CGSHiGG_09195 NC_009567.1 1701298 1702470 R COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; putative aspartate aminotransferase complement(1701298..1702470) Haemophilus influenzae PittGG 5227686 YP_001293023.1 CDS CGSHiGG_09200 NC_009567.1 1702746 1703873 R COG4214 ABC-type xylose transport system, permease component; D-xylose ABC transporter permease protein complement(1702746..1703873) Haemophilus influenzae PittGG 5227687 YP_001293024.1 CDS CGSHiGG_09205 NC_009567.1 1703877 1705388 R with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit complement(1703877..1705388) Haemophilus influenzae PittGG 5227688 YP_001293025.1 CDS xylF NC_009567.1 1705439 1706437 R periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF complement(1705439..1706437) Haemophilus influenzae PittGG 5227689 YP_001293026.1 CDS CGSHiGG_09215 NC_009567.1 1706671 1707990 D catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase 1706671..1707990 Haemophilus influenzae PittGG 5227690 YP_001293027.1 CDS CGSHiGG_09220 NC_009567.1 1708047 1709525 D COG1070 Sugar (pentulose and hexulose) kinases; xylose isomerase 1708047..1709525 Haemophilus influenzae PittGG 5227691 YP_001293028.1 CDS rfaD NC_009567.1 1709576 1710502 R catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-mannoheptose-6-epimerase complement(1709576..1710502) Haemophilus influenzae PittGG 5227692 YP_001293029.1 CDS rfaD NC_009567.1 1710555 1711034 R COG0526 Thiol-disulfide isomerase and thioredoxins; ADP-L-glycero-D-mannoheptose-6-epimerase complement(1710555..1711034) Haemophilus influenzae PittGG 5227693 YP_001293030.1 CDS CGSHiGG_09245 NC_009567.1 1711874 1713403 R COG0606 Predicted ATPase with chaperone activity; deoxyribose-phosphate aldolase complement(1711874..1713403) Haemophilus influenzae PittGG 5227694 YP_001293031.1 CDS engB NC_009567.1 1713518 1714135 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(1713518..1714135) Haemophilus influenzae PittGG 5227695 YP_001293032.1 CDS CGSHiGG_09255 NC_009567.1 1714174 1715106 D COG2990 Uncharacterized protein conserved in bacteria; D-xylose transport permease protein 1714174..1715106 Haemophilus influenzae PittGG 5227696 YP_001293033.1 CDS CGSHiGG_09260 NC_009567.1 1715146 1716144 R COG4608 ABC-type oligopeptide transport system, ATPase component; GTPase EngB complement(1715146..1716144) Haemophilus influenzae PittGG 5227697 YP_001293034.1 CDS oppD NC_009567.1 1716141 1717112 R COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component; oligopeptide transporter ATP-binding protein complement(1716141..1717112) Haemophilus influenzae PittGG 5227698 YP_001293035.1 CDS oppD NC_009567.1 1717122 1718057 R COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; oligopeptide transporter ATP-binding protein complement(1717122..1718057) Haemophilus influenzae PittGG 5227699 YP_001293036.1 CDS oppB NC_009567.1 1718067 1718909 R COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; oligopeptide transporter permease complement(1718067..1718909) Haemophilus influenzae PittGG 5227700 YP_001293037.1 CDS oppB NC_009567.1 1719069 1720694 R COG4166 ABC-type oligopeptide transport system, periplasmic component; oligopeptide permease ABC transporter membrane protein complement(1719069..1720694) Haemophilus influenzae PittGG 5227701 YP_001293038.1 CDS CGSHiGG_09285 NC_009567.1 1720988 1721941 D COG0176 Transaldolase; transaldolase B 1720988..1721941 Haemophilus influenzae PittGG 5227702 YP_001293039.1 CDS CGSHiGG_09290 NC_009567.1 1722590 1722820 R COG0777 Acetyl-CoA carboxylase beta subunit; hypothetical protein complement(1722590..1722820) Haemophilus influenzae PittGG 5227703 YP_001293040.1 CDS CGSHiGG_09295 NC_009567.1 1723017 1724603 D COG1966 Carbon starvation protein, predicted membrane protein; transaldolase B 1723017..1724603 Haemophilus influenzae PittGG 5227704 YP_001293041.1 CDS CGSHiGG_09300 NC_009567.1 1724815 1725270 D MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 1724815..1725270 Haemophilus influenzae PittGG 5227705 YP_001293042.1 CDS mraW NC_009567.1 1725301 1726170 D COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis; S-adenosyl-methyltransferase MraW 1725301..1726170 Haemophilus influenzae PittGG 5227706 YP_001293043.1 CDS CGSHiGG_09310 NC_009567.1 1726134 1726265 D COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis; S-adenosyl-methyltransferase 1726134..1726265 Haemophilus influenzae PittGG 5227707 YP_001293044.1 CDS CGSHiGG_09315 NC_009567.1 1726268 1726591 D COG3116 Cell division protein; cell division protein FtsL 1726268..1726591 Haemophilus influenzae PittGG 5227708 YP_001293045.1 CDS mraW NC_009567.1 1726603 1728435 D COG0768 Cell division protein FtsI/penicillin-binding protein 2; S-adenosyl-methyltransferase MraW 1726603..1728435 Haemophilus influenzae PittGG 5227709 YP_001293046.1 CDS murE NC_009567.1 1728445 1729911 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1728445..1729911 Haemophilus influenzae PittGG 5227710 YP_001293047.1 CDS murE NC_009567.1 1729925 1731298 D COG0770 UDP-N-acetylmuramyl pentapeptide synthase; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1729925..1731298 Haemophilus influenzae PittGG 5227711 YP_001293048.1 CDS mraY NC_009567.1 1731292 1732374 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 1731292..1732374 Haemophilus influenzae PittGG 5227712 YP_001293049.1 CDS murD NC_009567.1 1732486 1733799 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 1732486..1733799 Haemophilus influenzae PittGG 5227713 YP_001293050.1 CDS murD NC_009567.1 1733822 1735006 D COG0772 Bacterial cell division membrane protein; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 1733822..1735006 Haemophilus influenzae PittGG 5227714 YP_001293051.1 CDS murG NC_009567.1 1735018 1736073 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 1735018..1736073 Haemophilus influenzae PittGG 5227715 YP_001293052.1 CDS murC NC_009567.1 1736211 1737638 D Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 1736211..1737638 Haemophilus influenzae PittGG 5227716 YP_001293053.1 CDS ddl NC_009567.1 1737710 1738630 D D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 1737710..1738630 Haemophilus influenzae PittGG 5227717 YP_001293054.1 CDS CGSHiGG_09365 NC_009567.1 1738630 1739337 D COG1589 Cell division septal protein; cell division protein 1738630..1739337 Haemophilus influenzae PittGG 5227718 YP_001293055.1 CDS ddl NC_009567.1 1739412 1740689 D COG0849 Actin-like ATPase involved in cell division; D-alanine--D-alanine ligase 1739412..1740689 Haemophilus influenzae PittGG 5227719 YP_001293056.1 CDS CGSHiGG_09375 NC_009567.1 1740774 1742051 D GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1740774..1742051 Haemophilus influenzae PittGG 5227720 YP_001293057.1 CDS lpxC NC_009567.1 1742090 1743007 D zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 1742090..1743007 Haemophilus influenzae PittGG 5227721 YP_001293058.1 CDS CGSHiGG_09385 NC_009567.1 1743134 1744291 D COG1605 Chorismate mutase; cell division protein FtsZ 1743134..1744291 Haemophilus influenzae PittGG 5227722 YP_001293059.1 CDS CGSHiGG_09400 NC_009567.1 1745210 1745704 R COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); nitrogen regulatory IIA protein complement(1745210..1745704) Haemophilus influenzae PittGG 5227723 YP_001293060.1 CDS CGSHiGG_09405 NC_009567.1 1745707 1746432 R COG1137 ABC-type (unclassified) transport system, ATPase component; ABC transporter ATP-binding protein complement(1745707..1746432) Haemophilus influenzae PittGG 5227724 YP_001293061.1 CDS CGSHiGG_09410 NC_009567.1 1746436 1746954 R COG1934 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1746436..1746954) Haemophilus influenzae PittGG 5227725 YP_001293062.1 CDS CGSHiGG_09415 NC_009567.1 1746935 1747549 R COG3117 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1746935..1747549) Haemophilus influenzae PittGG 5227726 YP_001293063.1 CDS CGSHiGG_09420 NC_009567.1 1747600 1748136 R COG3028 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1747600..1748136) Haemophilus influenzae PittGG 5227727 YP_001293064.1 CDS CGSHiGG_09435 NC_009567.1 1749791 1750330 D COG0634 Hypoxanthine-guanine phosphoribosyltransferase; hypoxanthine-guanine phosphoribosyltransferase 1749791..1750330 Haemophilus influenzae PittGG 5227728 YP_001293065.1 CDS CGSHiGG_09440 NC_009567.1 1750332 1750541 D COG1280 Putative threonine efflux protein; hypothetical protein 1750332..1750541 Haemophilus influenzae PittGG 5227729 YP_001293066.1 CDS CGSHiGG_09445 NC_009567.1 1750623 1751957 D COG1823 Predicted Na+/dicarboxylate symporter; hypothetical protein 1750623..1751957 Haemophilus influenzae PittGG 5227730 YP_001293067.1 CDS nrdG NC_009567.1 1752057 1752524 R activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein complement(1752057..1752524) Haemophilus influenzae PittGG 5227731 YP_001293068.1 CDS CGSHiGG_09465 NC_009567.1 1754573 1756264 R in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component complement(1754573..1756264) Haemophilus influenzae PittGG 5227732 YP_001293069.1 CDS CGSHiGG_09480 NC_009567.1 1757365 1758222 R COG3118 Thioredoxin domain-containing protein; thioredoxin domain-containing protein complement(1757365..1758222) Haemophilus influenzae PittGG 5227733 YP_001293070.1 CDS CGSHiGG_09495 NC_009567.1 1759271 1759687 R COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; hypothetical protein complement(1759271..1759687) Haemophilus influenzae PittGG 5227734 YP_001293071.1 CDS CGSHiGG_09500 NC_009567.1 1759729 1760109 R COG2852 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1759729..1760109) Haemophilus influenzae PittGG 5227735 YP_001293072.1 CDS CGSHiGG_09505 NC_009567.1 1760187 1763270 R COG0277 FAD/FMN-containing dehydrogenases; hypothetical protein complement(1760187..1763270) Haemophilus influenzae PittGG 5227736 YP_001293073.1 CDS hemH NC_009567.1 1764859 1765182 D COG0278 Glutaredoxin-related protein; ferrochelatase 1764859..1765182 Haemophilus influenzae PittGG 5227737 YP_001293074.1 CDS CGSHiGG_09535 NC_009567.1 1766446 1767534 R catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase complement(1766446..1767534) Haemophilus influenzae PittGG 5227738 YP_001293075.1 CDS CGSHiGG_09540 NC_009567.1 1767725 1768069 D COG2926 Uncharacterized protein conserved in bacteria; hypothetical protein 1767725..1768069 Haemophilus influenzae PittGG 5227739 YP_001293076.1 CDS CGSHiGG_09545 NC_009567.1 1768110 1768676 R COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; hypothetical protein complement(1768110..1768676) Haemophilus influenzae PittGG 5227740 YP_001293077.1 CDS CGSHiGG_09550 NC_009567.1 1768676 1769647 R catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; para-aminobenzoate synthase component I complement(1768676..1769647) Haemophilus influenzae PittGG 5227741 YP_001293078.1 CDS CGSHiGG_09555 NC_009567.1 1769704 1770285 D catalyzes the formation of anthranilate from chorismate and glutamine; functions in tryptophan biosynthesis; putative anthranilate synthase component II 1769704..1770285 Haemophilus influenzae PittGG 5227742 YP_001293079.1 CDS CGSHiGG_09560 NC_009567.1 1770370 1771524 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1770370..1771524 Haemophilus influenzae PittGG 5227743 YP_001293080.1 CDS CGSHiGG_09565 NC_009567.1 1772015 1772335 D COG3091 Uncharacterized protein conserved in bacteria; hypothetical protein 1772015..1772335 Haemophilus influenzae PittGG 5227744 YP_001293081.1 CDS CGSHiGG_09570 NC_009567.1 1772386 1772898 D COG3637 Opacity protein and related surface antigens; opacity protein 1772386..1772898 Haemophilus influenzae PittGG 5227745 YP_001293082.1 CDS CGSHiGG_09575 NC_009567.1 1772996 1773496 R COG5295 Autotransporter adhesin; hypothetical protein complement(1772996..1773496) Haemophilus influenzae PittGG 5227746 YP_001293083.1 CDS artM NC_009567.1 1773515 1774198 R with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM complement(1773515..1774198) Haemophilus influenzae PittGG 5227747 YP_001293084.1 CDS CGSHiGG_09585 NC_009567.1 1774198 1774863 R with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ complement(1774198..1774863) Haemophilus influenzae PittGG 5227748 YP_001293085.1 CDS CGSHiGG_09590 NC_009567.1 1774867 1775586 R COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; arginine transporter permease subunit ArtQ complement(1774867..1775586) Haemophilus influenzae PittGG 5227749 YP_001293086.1 CDS artP NC_009567.1 1775603 1776334 R With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit complement(1775603..1776334) Haemophilus influenzae PittGG 5227750 YP_001293087.1 CDS gmhA NC_009567.1 1776461 1777045 R catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase complement(1776461..1777045) Haemophilus influenzae PittGG 5227751 YP_001293088.1 CDS CGSHiGG_09605 NC_009567.1 1777363 1778058 D catalyzes the formation of a phosphodiester at the site of a single-strand break in duplex DNA; DNA ligase 1777363..1778058 Haemophilus influenzae PittGG 5227752 YP_001293089.1 CDS dppF NC_009567.1 1778087 1779070 R Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit complement(1778087..1779070) Haemophilus influenzae PittGG 5227753 YP_001293090.1 CDS dppD NC_009567.1 1779073 1780065 R DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit complement(1779073..1780065) Haemophilus influenzae PittGG 5227754 YP_001293091.1 CDS dppD NC_009567.1 1780976 1781977 R COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; dipeptide transporter ATP-binding protein complement(1780976..1781977) Haemophilus influenzae PittGG 5227755 YP_001293092.1 CDS uvrD NC_009567.1 1782065 1784245 R unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II complement(1782065..1784245) Haemophilus influenzae PittGG 5227756 YP_001293093.1 CDS CGSHiGG_09640 NC_009567.1 1784232 1784465 R COG0210 Superfamily I DNA and RNA helicases; hypothetical protein complement(1784232..1784465) Haemophilus influenzae PittGG 5227757 YP_001293094.1 CDS CGSHiGG_09655 NC_009567.1 1785496 1785921 R COG0720 6-pyruvoyl-tetrahydropterin synthase; 6-pyruvoyl tetrahydrobiopterin synthase complement(1785496..1785921) Haemophilus influenzae PittGG 5227758 YP_001293095.1 CDS uvrD NC_009567.1 1786753 1786896 D COG0603 Predicted PP-loop superfamily ATPase; hypothetical protein 1786753..1786896 Haemophilus influenzae PittGG 5227759 YP_001293096.1 CDS CGSHiGG_09675 NC_009567.1 1786947 1787978 R catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase complement(1786947..1787978) Haemophilus influenzae PittGG 5227760 YP_001293097.1 CDS CGSHiGG_09680 NC_009567.1 1788452 1789345 D Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA 1788452..1789345 Haemophilus influenzae PittGG 5227761 YP_001293098.1 CDS CGSHiGG_09685 NC_009567.1 1789338 1790429 D COG2933 Predicted SAM-dependent methyltransferase; putative RNA 2'-O-ribose methyltransferase 1789338..1790429 Haemophilus influenzae PittGG 5227762 YP_001293099.1 CDS CGSHiGG_09690 NC_009567.1 1790465 1791649 D catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 1790465..1791649 Haemophilus influenzae PittGG 5227763 YP_001293100.1 CDS CGSHiGG_09705 NC_009567.1 1792510 1792635 R COG0074 Succinyl-CoA synthetase, alpha subunit; hypothetical protein complement(1792510..1792635) Haemophilus influenzae PittGG 5227764 YP_001293101.1 CDS CGSHiGG_09710 NC_009567.1 1792634 1793257 D COG0009 Putative translation factor (SUA5); hypothetical protein 1792634..1793257 Haemophilus influenzae PittGG 5227765 YP_001293102.1 CDS CGSHiGG_09715 NC_009567.1 1793305 1794378 D COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; methyltransferase 1793305..1794378 Haemophilus influenzae PittGG 5227766 YP_001293103.1 CDS cysB NC_009567.1 1794389 1795360 D LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1794389..1795360 Haemophilus influenzae PittGG 5227767 YP_001293104.1 CDS CGSHiGG_09725 NC_009567.1 1795419 1796363 R involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase complement(1795419..1796363) Haemophilus influenzae PittGG 5227768 YP_001293105.1 CDS CGSHiGG_09730 NC_009567.1 1796494 1796997 D COG2840 Uncharacterized protein conserved in bacteria; hypothetical protein 1796494..1796997 Haemophilus influenzae PittGG 5227769 YP_001293106.1 CDS CGSHiGG_09735 NC_009567.1 1797074 1799209 R catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase complement(1797074..1799209) Haemophilus influenzae PittGG 5227770 YP_001293107.1 CDS CGSHiGG_09740 NC_009567.1 1799277 1800482 R AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase complement(1799277..1800482) Haemophilus influenzae PittGG 5227771 YP_001293108.1 CDS CGSHiGG_09755 NC_009567.1 1801228 1801719 D COG1286 Uncharacterized membrane protein, required for colicin V production; hypothetical protein 1801228..1801719 Haemophilus influenzae PittGG 5227772 YP_001293109.1 CDS CGSHiGG_09760 NC_009567.1 1801730 1803247 D Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 1801730..1803247 Haemophilus influenzae PittGG 5227773 YP_001293110.1 CDS CGSHiGG_09765 NC_009567.1 1803302 1804192 R COG1090 Predicted nucleoside-diphosphate sugar epimerase; amidophosphoribosyltransferase complement(1803302..1804192) Haemophilus influenzae PittGG 5227774 YP_001293111.1 CDS CGSHiGG_09770 NC_009567.1 1804192 1804647 R regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor complement(1804192..1804647) Haemophilus influenzae PittGG 5227775 YP_001293112.1 CDS CGSHiGG_09775 NC_009567.1 1804854 1805789 D oxidizes malate to oxaloacetate; malate dehydrogenase 1804854..1805789 Haemophilus influenzae PittGG 5227776 YP_001293113.1 CDS lysS NC_009567.1 1805876 1807384 R class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(1805876..1807384) Haemophilus influenzae PittGG 5227777 YP_001293114.1 CDS CGSHiGG_09785 NC_009567.1 1807537 1808283 R COG1186 Protein chain release factor B; peptide chain release factor 2 complement(1807537..1808283) Haemophilus influenzae PittGG 5227778 YP_001293115.1 CDS CGSHiGG_09790 NC_009567.1 1808768 1809457 D COG1651 Protein-disulfide isomerase; thiol-disulfide interchange protein 1808768..1809457 Haemophilus influenzae PittGG 5227779 YP_001293116.1 CDS lysS NC_009567.1 1811480 1812133 D COG0526 Thiol-disulfide isomerase and thioredoxins; lysyl-tRNA synthetase 1811480..1812133 Haemophilus influenzae PittGG 5227780 YP_001293117.1 CDS CGSHiGG_09810 NC_009567.1 1812171 1812860 D enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1812171..1812860 Haemophilus influenzae PittGG 5227781 YP_001293118.1 CDS CGSHiGG_09830 NC_009567.1 1815995 1817593 R 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase complement(1815995..1817593) Haemophilus influenzae PittGG 5227782 YP_001293119.1 CDS cmk NC_009567.1 1817867 1817962 D COG1620 L-lactate permease; cytidylate kinase 1817867..1817962 Haemophilus influenzae PittGG 5227783 YP_001293120.1 CDS CGSHiGG_09850 NC_009567.1 1819057 1819191 D COG0158 Fructose-1,6-bisphosphatase; hypothetical protein 1819057..1819191 Haemophilus influenzae PittGG 5227784 YP_001293121.1 CDS truA NC_009567.1 1819237 1820046 D mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1819237..1820046 Haemophilus influenzae PittGG 5227785 YP_001293122.1 CDS CGSHiGG_09860 NC_009567.1 1820139 1821155 R COG2855 Predicted membrane protein; hypothetical protein complement(1820139..1821155) Haemophilus influenzae PittGG 5227786 YP_001293123.1 CDS CGSHiGG_09865 NC_009567.1 1821167 1821976 R COG4167 ABC-type antimicrobial peptide transport system, ATPase component; anti peptide resistance ABC transporter ATPase complement(1821167..1821976) Haemophilus influenzae PittGG 5227787 YP_001293124.1 CDS CGSHiGG_09870 NC_009567.1 1821976 1823025 R COG4170 ABC-type antimicrobial peptide transport system, ATPase component; peptide ABC transporter ATP-binding protein complement(1821976..1823025) Haemophilus influenzae PittGG 5227788 YP_001293125.1 CDS CGSHiGG_09875 NC_009567.1 1823069 1823917 R COG4171 ABC-type antimicrobial peptide transport system, permease component; peptide ABC transporter permease protein complement(1823069..1823917) Haemophilus influenzae PittGG 5227789 YP_001293126.1 CDS CGSHiGG_09890 NC_009567.1 1824873 1826567 R COG4166 ABC-type oligopeptide transport system, periplasmic component; anti peptide resistance ABC transporter periplasmic protein complement(1824873..1826567) Haemophilus influenzae PittGG 5227790 YP_001293127.1 CDS truA NC_009567.1 1826637 1828049 D COG3106 Predicted ATPase; hypothetical protein 1826637..1828049 Haemophilus influenzae PittGG 5227791 YP_001293128.1 CDS CGSHiGG_09900 NC_009567.1 1828087 1830726 R catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase complement(1828087..1830726) Haemophilus influenzae PittGG 5227792 YP_001293129.1 CDS CGSHiGG_09905 NC_009567.1 1830909 1831919 R binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR complement(1830909..1831919) Haemophilus influenzae PittGG 5227793 YP_001293131.1 CDS CGSHiGG_09925 NC_009567.1 1833165 1834463 R catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase complement(1833165..1834463) Haemophilus influenzae PittGG 5227795 YP_001293132.1 CDS CGSHiGG_09930 NC_009567.1 1834592 1834957 R adenylosuccinate synthetase complement(1834592..1834957) Haemophilus influenzae PittGG 5227796 YP_001293134.1 CDS CGSHiGG_09940 NC_009567.1 1835809 1836096 R the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 complement(1835809..1836096) Haemophilus influenzae PittGG 5227798 YP_001293135.1 CDS CGSHiGG_09945 NC_009567.1 1836314 1836919 D COG0586 Uncharacterized membrane-associated protein; membrane-associated protein 1836314..1836919 Haemophilus influenzae PittGG 5227799 YP_001293136.1 CDS CGSHiGG_09950 NC_009567.1 1836966 1837370 R COG3105 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1836966..1837370) Haemophilus influenzae PittGG 5227800 YP_001293137.1 CDS CGSHiGG_09955 NC_009567.1 1837401 1837751 R hypothetical protein complement(1837401..1837751) Haemophilus influenzae PittGG 5227801 YP_001293138.1 CDS CGSHiGG_09970 NC_009567.1 1838579 1839121 D COG0790 FOG: TPR repeat, SEL1 subfamily; hypothetical protein 1838579..1839121 Haemophilus influenzae PittGG 5227802 YP_001293139.1 CDS CGSHiGG_09975 NC_009567.1 1839135 1839542 R COG0789 Predicted transcriptional regulators; mercuric resistance operon regulatory protein complement(1839135..1839542) Haemophilus influenzae PittGG 5227803 YP_001293140.1 CDS CGSHiGG_09980 NC_009567.1 1839632 1840315 D COG5266 ABC-type Co2+ transport system, periplasmic component; putative ABC-type Co2+ transport system, periplasmic component 1839632..1840315 Haemophilus influenzae PittGG 5227804 YP_001293141.1 CDS CGSHiGG_09985 NC_009567.1 1840328 1840813 D COG0013 Alanyl-tRNA synthetase; hypothetical protein 1840328..1840813 Haemophilus influenzae PittGG 5227805 YP_001293142.1 CDS CGSHiGG_09990 NC_009567.1 1840813 1841433 D catalyzes the ATP-dependent transport of cobalt; cobalt transport protein CbiM 1840813..1841433 Haemophilus influenzae PittGG 5227806 YP_001293143.1 CDS CGSHiGG_09995 NC_009567.1 1841433 1842065 D COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters; cobalt ABC transporter permease 1841433..1842065 Haemophilus influenzae PittGG 5227807 YP_001293144.1 CDS CGSHiGG_10000 NC_009567.1 1842067 1842516 D COG1122 ABC-type cobalt transport system, ATPase component; cobalt transport protein CbiM 1842067..1842516 Haemophilus influenzae PittGG 5227808 YP_001293145.1 CDS CGSHiGG_10005 NC_009567.1 1842904 1844094 R catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase complement(1842904..1844094) Haemophilus influenzae PittGG 5227809 YP_001293146.1 CDS CGSHiGG_10010 NC_009567.1 1844234 1845322 R With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit complement(1844234..1845322) Haemophilus influenzae PittGG 5227810 YP_001293147.1 CDS CGSHiGG_10015 NC_009567.1 1845393 1845728 R COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; phosphoribosylaminoimidazole carboxylase catalytic subunit complement(1845393..1845728) Haemophilus influenzae PittGG 5227811 YP_001293148.1 CDS CGSHiGG_10020 NC_009567.1 1846227 1846571 D COG4226 Uncharacterized protein encoded in hypervariable junctions of pilus gene clusters; hypothetical protein 1846227..1846571 Haemophilus influenzae PittGG 5227812 YP_001293149.1 CDS CGSHiGG_10025 NC_009567.1 1846712 1847320 R COG3539 P pilus assembly protein, pilin FimA; putative F17-like fimbrial subunit complement(1846712..1847320) Haemophilus influenzae PittGG 5227813 YP_001293150.1 CDS CGSHiGG_10030 NC_009567.1 1847861 1848499 D COG3121 P pilus assembly protein, chaperone PapD; putative F17-like fimbrial chaperone 1847861..1848499 Haemophilus influenzae PittGG 5227814 YP_001293151.1 CDS CGSHiGG_10035 NC_009567.1 1848614 1851127 D COG3188 P pilus assembly protein, porin PapC; putative F17-like fimbrial usher 1848614..1851127 Haemophilus influenzae PittGG 5227815 YP_001293152.1 CDS CGSHiGG_10040 NC_009567.1 1851141 1851803 D S-fimbrial protein subunit 1851141..1851803 Haemophilus influenzae PittGG 5227816 YP_001293153.1 CDS CGSHiGG_10045 NC_009567.1 1851830 1853143 D COG3539 P pilus assembly protein, pilin FimA; hypothetical protein 1851830..1853143 Haemophilus influenzae PittGG 5227817 YP_001293154.1 CDS pepN NC_009567.1 1853401 1856010 D COG0308 Aminopeptidase N; aminopeptidase N 1853401..1856010 Haemophilus influenzae PittGG 5227818 YP_001293155.1 CDS CGSHiGG_10055 NC_009567.1 1856082 1856696 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(1856082..1856696) Haemophilus influenzae PittGG 5227819 YP_001293156.1 CDS CGSHiGG_10060 NC_009567.1 1856740 1858134 D NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1856740..1858134 Haemophilus influenzae PittGG 5227820 YP_001293157.1 CDS CGSHiGG_10065 NC_009567.1 1858143 1858859 D Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A 1858143..1858859 Haemophilus influenzae PittGG 5227821 YP_001293158.1 CDS CGSHiGG_10070 NC_009567.1 1859057 1860244 D catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1859057..1860244 Haemophilus influenzae PittGG 5227822 YP_001293159.1 CDS CGSHiGG_10075 NC_009567.1 1860327 1861274 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(1860327..1861274) Haemophilus influenzae PittGG 5227823 YP_001293160.1 CDS ipk NC_009567.1 1861276 1862229 R An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase complement(1861276..1862229) Haemophilus influenzae PittGG 5227825 YP_001293161.1 CDS lolB NC_009567.1 1862229 1862849 R Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB complement(1862229..1862849) Haemophilus influenzae PittGG 5227828 YP_001293162.1 CDS cca NC_009567.1 1862921 1864171 R catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase complement(1862921..1864171) Haemophilus influenzae PittGG 5227829 YP_001293163.1 CDS CGSHiGG_10095 NC_009567.1 1864178 1864789 R COG3103 SH3 domain protein; hypothetical protein complement(1864178..1864789) Haemophilus influenzae PittGG 5227830 YP_001293164.1 CDS CGSHiGG_10100 NC_009567.1 1864855 1866117 R COG0306 Phosphate/sulphate permeases; phosphate permease complement(1864855..1866117) Haemophilus influenzae PittGG 5227831 YP_001293165.1 CDS CGSHiGG_10105 NC_009567.1 1866142 1866822 R COG1392 Phosphate transport regulator (distant homolog of PhoU); phosphate transport regulator complement(1866142..1866822) Haemophilus influenzae PittGG 5227832 YP_001293166.1 CDS CGSHiGG_10110 NC_009567.1 1867045 1867485 D COG2259 Predicted membrane protein; hypothetical protein 1867045..1867485 Haemophilus influenzae PittGG 5227833 YP_001293167.1 CDS lolB NC_009567.1 1867524 1867811 D COG3767 Uncharacterized low-complexity protein; hypothetical protein 1867524..1867811 Haemophilus influenzae PittGG 5227834 YP_001293168.1 CDS CGSHiGG_10120 NC_009567.1 1867871 1868794 D COG3220 Uncharacterized protein conserved in bacteria; hypothetical protein 1867871..1868794 Haemophilus influenzae PittGG 5227835 YP_001293169.1 CDS CGSHiGG_10125 NC_009567.1 1868784 1869500 D COG3219 Uncharacterized protein conserved in bacteria; hypothetical protein 1868784..1869500 Haemophilus influenzae PittGG 5227836 YP_001293170.1 CDS CGSHiGG_10130 NC_009567.1 1869824 1870870 D COG3025 Uncharacterized conserved protein; hypothetical protein 1869824..1870870 Haemophilus influenzae PittGG 5227837 YP_001293171.1 CDS CGSHiGG_10145 NC_009567.1 1872461 1872940 D mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 1872461..1872940 Haemophilus influenzae PittGG 5227838 YP_001293172.1 CDS lolA NC_009567.1 1875752 1876309 D participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 1875752..1876309 Haemophilus influenzae PittGG 5227839 YP_001293173.1 CDS lolA NC_009567.1 1876370 1877710 D COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase; recombination factor protein RarA 1876370..1877710 Haemophilus influenzae PittGG 5227840 YP_001293174.1 CDS CGSHiGG_10170 NC_009567.1 1877792 1879090 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(1877792..1879090) Haemophilus influenzae PittGG 5227841 YP_001293175.1 CDS purU NC_009567.1 1879090 1879926 R produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase complement(1879090..1879926) Haemophilus influenzae PittGG 5227842 YP_001293176.1 CDS CGSHiGG_10180 NC_009567.1 1879996 1880400 R COG2916 DNA-binding protein H-NS; hypothetical protein complement(1879996..1880400) Haemophilus influenzae PittGG 5227843 YP_001293177.1 CDS purU NC_009567.1 1882431 1882580 D COG1757 Na+/H+ antiporter; formyltetrahydrofolate deformylase 1882431..1882580 Haemophilus influenzae PittGG 5227844 YP_001293178.1 CDS ilvH NC_009567.1 1884449 1884844 D COG0440 Acetolactate synthase, small (regulatory) subunit; acetolactate synthase 3 regulatory subunit 1884449..1884844 Haemophilus influenzae PittGG 5227845 YP_001293179.1 CDS argS NC_009567.1 1885131 1886864 R catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase complement(1885131..1886864) Haemophilus influenzae PittGG 5227846 CGSHiGG_t10227 tRNA CGSHiGG_t10227 NC_009567.1 8968 9044 D tRNA-Val 8968..9044 Haemophilus influenzae PittGG 5227935 CGSHiGG_t10363 tRNA CGSHiGG_t10363 NC_009567.1 171204 171289 R tRNA-Leu complement(171204..171289) Haemophilus influenzae PittGG 5542209 CGSHiGG_t10365 tRNA CGSHiGG_t10365 NC_009567.1 269769 269845 R tRNA-Met complement(269769..269845) Haemophilus influenzae PittGG 5542189 CGSHiGG_t10367 tRNA CGSHiGG_t10367 NC_009567.1 303249 303324 R tRNA-Asn complement(303249..303324) Haemophilus influenzae PittGG 5542212 CGSHiGG_t10369 tRNA CGSHiGG_t10369 NC_009567.1 416927 417002 D tRNA-Gly 416927..417002 Haemophilus influenzae PittGG 5542171 CGSHiGG_t10371 tRNA CGSHiGG_t10371 NC_009567.1 442865 442940 R tRNA-Glu complement(442865..442940) Haemophilus influenzae PittGG 5542166 CGSHiGG_t10373 tRNA CGSHiGG_t10373 NC_009567.1 499930 500019 D tRNA-Ser 499930..500019 Haemophilus influenzae PittGG 5542204 CGSHiGG_t10375 tRNA CGSHiGG_t10375 NC_009567.1 544393 544468 D tRNA-Gly 544393..544468 Haemophilus influenzae PittGG 5542197 CGSHiGG_t10377 tRNA CGSHiGG_t10377 NC_009567.1 544475 544548 D tRNA-Cys 544475..544548 Haemophilus influenzae PittGG 5542174 CGSHiGG_t10379 tRNA CGSHiGG_t10379 NC_009567.1 544576 544662 D tRNA-Leu 544576..544662 Haemophilus influenzae PittGG 5542164 CGSHiGG_t10381 tRNA CGSHiGG_t10381 NC_009567.1 544713 544788 D tRNA-Lys 544713..544788 Haemophilus influenzae PittGG 5542172 CGSHiGG_t10383 tRNA CGSHiGG_t10383 NC_009567.1 582885 582960 R tRNA-Ala complement(582885..582960) Haemophilus influenzae PittGG 5542170 CGSHiGG_t10385 tRNA CGSHiGG_t10385 NC_009567.1 583046 583122 R tRNA-Ile complement(583046..583122) Haemophilus influenzae PittGG 5542181 CGSHiGG_t10387 tRNA CGSHiGG_t10387 NC_009567.1 584917 584993 R tRNA-Pro complement(584917..584993) Haemophilus influenzae PittGG 5542160 CGSHiGG_t10389 tRNA CGSHiGG_t10389 NC_009567.1 585015 585090 R tRNA-His complement(585015..585090) Haemophilus influenzae PittGG 5542161 CGSHiGG_t10391 tRNA CGSHiGG_t10391 NC_009567.1 585117 585193 R tRNA-Arg complement(585117..585193) Haemophilus influenzae PittGG 5542162 CGSHiGG_t10393 tRNA CGSHiGG_t10393 NC_009567.1 587607 587683 R tRNA-Met complement(587607..587683) Haemophilus influenzae PittGG 5542186 CGSHiGG_t10395 tRNA CGSHiGG_t10395 NC_009567.1 596281 596356 D tRNA-Gly 596281..596356 Haemophilus influenzae PittGG 5542185 CGSHiGG_t10397 tRNA CGSHiGG_t10397 NC_009567.1 596361 596447 D tRNA-Leu 596361..596447 Haemophilus influenzae PittGG 5542157 CGSHiGG_t10399 tRNA CGSHiGG_t10399 NC_009567.1 596499 596574 D tRNA-Lys 596499..596574 Haemophilus influenzae PittGG 5542183 CGSHiGG_t10401 tRNA CGSHiGG_t10401 NC_009567.1 608977 609053 R tRNA-Asp complement(608977..609053) Haemophilus influenzae PittGG 5542194 CGSHiGG_t10403 tRNA CGSHiGG_t10403 NC_009567.1 609077 609153 R tRNA-Asp complement(609077..609153) Haemophilus influenzae PittGG 5542190 CGSHiGG_t10405 tRNA CGSHiGG_t10405 NC_009567.1 702934 703009 R tRNA-Glu complement(702934..703009) Haemophilus influenzae PittGG 5542159 CGSHiGG_t10407 tRNA CGSHiGG_t10407 NC_009567.1 766832 766921 R tRNA-Ser complement(766832..766921) Haemophilus influenzae PittGG 5542179 CGSHiGG_t10409 tRNA CGSHiGG_t10409 NC_009567.1 785483 785558 R tRNA-Ala complement(785483..785558) Haemophilus influenzae PittGG 5542182 CGSHiGG_t10411 tRNA CGSHiGG_t10411 NC_009567.1 787371 787446 D tRNA-Val 787371..787446 Haemophilus influenzae PittGG 5542187 CGSHiGG_t10413 tRNA CGSHiGG_t10413 NC_009567.1 787505 787580 D tRNA-Val 787505..787580 Haemophilus influenzae PittGG 5542210 CGSHiGG_t10415 tRNA CGSHiGG_t10415 NC_009567.1 787633 787708 D tRNA-Val 787633..787708 Haemophilus influenzae PittGG 5542215 CGSHiGG_t10417 tRNA CGSHiGG_t10417 NC_009567.1 833409 833498 R tRNA-Ser complement(833409..833498) Haemophilus influenzae PittGG 5542188 CGSHiGG_t10419 tRNA CGSHiGG_t10419 NC_009567.1 925415 925490 R tRNA-Lys complement(925415..925490) Haemophilus influenzae PittGG 5542207 CGSHiGG_t10421 tRNA CGSHiGG_t10421 NC_009567.1 925514 925589 R tRNA-Lys complement(925514..925589) Haemophilus influenzae PittGG 5542173 CGSHiGG_t10423 tRNA CGSHiGG_t10423 NC_009567.1 991432 991517 D tRNA-Leu 991432..991517 Haemophilus influenzae PittGG 5542177 CGSHiGG_t10425 tRNA CGSHiGG_t10425 NC_009567.1 1123258 1123333 R tRNA-Thr complement(1123258..1123333) Haemophilus influenzae PittGG 5542168 CGSHiGG_t10427 tRNA CGSHiGG_t10427 NC_009567.1 1123337 1123411 R tRNA-Gly complement(1123337..1123411) Haemophilus influenzae PittGG 5542205 CGSHiGG_t10429 tRNA CGSHiGG_t10429 NC_009567.1 1123454 1123538 R tRNA-Tyr complement(1123454..1123538) Haemophilus influenzae PittGG 5542206 CGSHiGG_t10431 tRNA CGSHiGG_t10431 NC_009567.1 1123568 1123644 R tRNA-OTHER complement(1123568..1123644) Haemophilus influenzae PittGG 5542192 CGSHiGG_t10433 tRNA CGSHiGG_t10433 NC_009567.1 1137993 1138068 R tRNA-Glu complement(1137993..1138068) Haemophilus influenzae PittGG 5542214 CGSHiGG_t10435 tRNA CGSHiGG_t10435 NC_009567.1 1181244 1181320 R tRNA-Arg complement(1181244..1181320) Haemophilus influenzae PittGG 5542167 CGSHiGG_t10437 tRNA CGSHiGG_t10437 NC_009567.1 1181378 1181454 R tRNA-Arg complement(1181378..1181454) Haemophilus influenzae PittGG 5542201 CGSHiGG_t10439 tRNA CGSHiGG_t10439 NC_009567.1 1181475 1181568 R tRNA-Ser complement(1181475..1181568) Haemophilus influenzae PittGG 5542202 CGSHiGG_t10441 tRNA CGSHiGG_t10441 NC_009567.1 1251738 1251832 R tRNA-Sec complement(1251738..1251832) Haemophilus influenzae PittGG 5542176 CGSHiGG_r10469 tRNA CGSHiGG_r10469 NC_009567.1 1270704 1270780 D tRNA-Ile 1270704..1270780 Haemophilus influenzae PittGG 5542180 CGSHiGG_t10443 tRNA CGSHiGG_t10443 NC_009567.1 1270866 1270941 D tRNA-Ala 1270866..1270941 Haemophilus influenzae PittGG 5542163 CGSHiGG_t10445 tRNA CGSHiGG_t10445 NC_009567.1 1275003 1275079 D tRNA-Asp 1275003..1275079 Haemophilus influenzae PittGG 5542199 CGSHiGG_t10447 tRNA CGSHiGG_t10447 NC_009567.1 1275108 1275183 D tRNA-Trp 1275108..1275183 Haemophilus influenzae PittGG 5542200 CGSHiGG_t10449 tRNA CGSHiGG_t10449 NC_009567.1 1286680 1286756 D tRNA-Pro 1286680..1286756 Haemophilus influenzae PittGG 5542156 CGSHiGG_t10451 tRNA CGSHiGG_t10451 NC_009567.1 1286804 1286880 D tRNA-Arg 1286804..1286880 Haemophilus influenzae PittGG 5542195 CGSHiGG_t10453 tRNA CGSHiGG_t10453 NC_009567.1 1304366 1304441 D tRNA-Glu 1304366..1304441 Haemophilus influenzae PittGG 5542196 CGSHiGG_t10455 tRNA CGSHiGG_t10455 NC_009567.1 1356425 1356500 D tRNA-Phe 1356425..1356500 Haemophilus influenzae PittGG 5542203 CGSHiGG_t10457 tRNA CGSHiGG_t10457 NC_009567.1 1356503 1356578 D tRNA-Asn 1356503..1356578 Haemophilus influenzae PittGG 5542175 CGSHiGG_t10459 tRNA CGSHiGG_t10459 NC_009567.1 1512626 1512702 R tRNA-Met complement(1512626..1512702) Haemophilus influenzae PittGG 5542191 CGSHiGG_t10461 tRNA CGSHiGG_t10461 NC_009567.1 1835264 1835340 D tRNA-Met 1835264..1835340 Haemophilus influenzae PittGG 5542193 CGSHiGG_t10463 tRNA CGSHiGG_t10463 NC_009567.1 1835346 1835430 D tRNA-Leu 1835346..1835430 Haemophilus influenzae PittGG 5542208 CGSHiGG_t10465 tRNA CGSHiGG_t10465 NC_009567.1 1835459 1835533 D tRNA-Gln 1835459..1835533 Haemophilus influenzae PittGG 5542198 CGSHiGG_t10467 tRNA CGSHiGG_t10467 NC_009567.1 1835581 1835655 D tRNA-Gln 1835581..1835655 Haemophilus influenzae PittGG 5542213 CGSHiGG_r10325 rRNA CGSHiGG_r10325 NC_009567.1 439167 439286 R 5S ribosomal RNA complement(439167..439286) Haemophilus influenzae PittGG 5227000 CGSHiGG_r10351 rRNA CGSHiGG_r10351 NC_009567.1 439482 442590 R 23S ribosomal RNA complement(join(439482..441225,441313..442590)) Haemophilus influenzae PittGG 5542165 CGSHiGG_r10337 rRNA CGSHiGG_r10337 NC_009567.1 443072 444611 R 16S ribosomal RNA complement(443072..444611) Haemophilus influenzae PittGG 5227001 CGSHiGG_r10327 rRNA CGSHiGG_r10327 NC_009567.1 578998 579117 R 5S ribosomal RNA complement(578998..579117) Haemophilus influenzae PittGG 5227113 CGSHiGG_r10353 rRNA CGSHiGG_r10353 NC_009567.1 579362 582470 R 23S ribosomal RNA complement(join(579362..581105,581193..582470)) Haemophilus influenzae PittGG 5542184 CGSHiGG_r10339 rRNA CGSHiGG_r10339 NC_009567.1 583202 584741 R 16S ribosomal RNA complement(583202..584741) Haemophilus influenzae PittGG 5227114 CGSHiGG_r10329 rRNA CGSHiGG_r10329 NC_009567.1 699187 699306 R 5S ribosomal RNA complement(699187..699306) Haemophilus influenzae PittGG 5227221 CGSHiGG_r10355 rRNA CGSHiGG_r10355 NC_009567.1 699551 702659 R 23S ribosomal RNA complement(join(699551..701294,701382..702659)) Haemophilus influenzae PittGG 5542158 CGSHiGG_r10341 rRNA CGSHiGG_r10341 NC_009567.1 703141 704680 R 16S ribosomal RNA complement(703141..704680) Haemophilus influenzae PittGG 5227222 CGSHiGG_r10331 rRNA CGSHiGG_r10331 NC_009567.1 1134264 1134383 R 5S ribosomal RNA complement(1134264..1134383) Haemophilus influenzae PittGG 5226556 CGSHiGG_r10357 rRNA CGSHiGG_r10357 NC_009567.1 1134612 1137718 R 23S ribosomal RNA complement(join(1134612..1136353,1136441..1137718)) Haemophilus influenzae PittGG 5542211 CGSHiGG_r10343 rRNA CGSHiGG_r10343 NC_009567.1 1138200 1139736 R 16S ribosomal RNA complement(1138200..1139736) Haemophilus influenzae PittGG 5226557 CGSHiGG_r10345 rRNA CGSHiGG_r10345 NC_009567.1 1269085 1270624 D 16S ribosomal RNA 1269085..1270624 Haemophilus influenzae PittGG 5226666 CGSHiGG_r10359 rRNA CGSHiGG_r10359 NC_009567.1 1271353 1274464 D 23S ribosomal RNA join(1271353..1272633,1272721..1274464) Haemophilus influenzae PittGG 5291012 CGSHiGG_r10333 rRNA CGSHiGG_r10333 NC_009567.1 1274709 1274828 D 5S ribosomal RNA 1274709..1274828 Haemophilus influenzae PittGG 5226667 CGSHiGG_r10349 rRNA CGSHiGG_r10349 NC_009567.1 1274873 1274992 D 5S ribosomal RNA 1274873..1274992 Haemophilus influenzae PittGG 5542169 CGSHiGG_r10347 rRNA CGSHiGG_r10347 NC_009567.1 1302695 1304234 D 16S ribosomal RNA 1302695..1304234 Haemophilus influenzae PittGG 5226694 CGSHiGG_r10361 rRNA CGSHiGG_r10361 NC_009567.1 1304713 1307824 D 23S ribosomal RNA join(1304713..1305993,1306081..1307824) Haemophilus influenzae PittGG 5542178 CGSHiGG_r10335 rRNA CGSHiGG_r10335 NC_009567.1 1308068 1308187 D 5S ribosomal RNA 1308068..1308187 Haemophilus influenzae PittGG 5226699