-- dump date 20140619_104414 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_001291510.1 148828427 5227848 join(1886944..1887192,1..333) 1 NC_009567.1 COG3102 Uncharacterized protein conserved in bacteria; hypothetical protein 333 5227848 CGSHiGG_10220 Haemophilus influenzae PittGG hypothetical protein YP_001291510.1 1886944 D 374931 CDS YP_001291511.1 148826758 5227847 370..621 1 NC_009567.1 COG3102 Uncharacterized protein conserved in bacteria; lipoprotein 621 5227847 CGSHiGG_00010 Haemophilus influenzae PittGG lipoprotein YP_001291511.1 370 D 374931 CDS YP_001291512.1 148826759 5227928 647..1111 1 NC_009567.1 COG3133 Outer membrane lipoprotein; 15 kDa peptidoglycan-associated lipoprotein 1111 5227928 CGSHiGG_00015 Haemophilus influenzae PittGG 15 kDa peptidoglycan-associated lipoprotein YP_001291512.1 647 D 374931 CDS YP_001291513.1 148826760 5227929 complement(1569..2264) 1 NC_009567.1 hypothetical protein 2264 5227929 CGSHiGG_00020 Haemophilus influenzae PittGG hypothetical protein YP_001291513.1 1569 R 374931 CDS YP_001291514.1 148826761 5227930 complement(2360..2581) 1 NC_009567.1 hypothetical protein 2581 5227930 CGSHiGG_00025 Haemophilus influenzae PittGG hypothetical protein YP_001291514.1 2360 R 374931 CDS YP_001291515.1 148826762 5227931 complement(2583..2681) 1 NC_009567.1 COG0463 Glycosyltransferases involved in cell wall biogenesis; hypothetical protein 2681 5227931 CGSHiGG_00030 Haemophilus influenzae PittGG hypothetical protein YP_001291515.1 2583 R 374931 CDS YP_001291516.1 148826763 5227932 complement(2916..4565) 1 NC_009567.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 4565 pgi 5227932 pgi Haemophilus influenzae PittGG glucose-6-phosphate isomerase YP_001291516.1 2916 R 374931 CDS YP_001291517.1 148826764 5227933 complement(4662..5744) 1 NC_009567.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 5744 alr 5227933 alr Haemophilus influenzae PittGG alanine racemase YP_001291517.1 4662 R 374931 CDS YP_001291518.1 148826765 5227934 complement(7302..8738) 1 NC_009567.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 8738 5227934 CGSHiGG_00060 Haemophilus influenzae PittGG pyruvate kinase YP_001291518.1 7302 R 374931 CDS YP_001291519.1 148826766 5227936 9247..9567 1 NC_009567.1 putative integrase 9567 5227936 CGSHiGG_00065 Haemophilus influenzae PittGG putative integrase YP_001291519.1 9247 D 374931 CDS YP_001291520.1 148826767 5227937 complement(9557..9928) 1 NC_009567.1 COG0582 Integrase; hypothetical protein 9928 5227937 CGSHiGG_00070 Haemophilus influenzae PittGG hypothetical protein YP_001291520.1 9557 R 374931 CDS YP_001291521.1 148826768 5227938 10056..10226 1 NC_009567.1 integrase 10226 5227938 CGSHiGG_00075 Haemophilus influenzae PittGG integrase YP_001291521.1 10056 D 374931 CDS YP_001291522.1 148826769 5227939 complement(10165..10689) 1 NC_009567.1 COG0582 Integrase; hypothetical protein 10689 5227939 CGSHiGG_00080 Haemophilus influenzae PittGG hypothetical protein YP_001291522.1 10165 R 374931 CDS YP_001291523.1 148826770 5227940 10689..10922 1 NC_009567.1 hypothetical protein 10922 5227940 CGSHiGG_00085 Haemophilus influenzae PittGG hypothetical protein YP_001291523.1 10689 D 374931 CDS YP_001291524.1 148826771 5227941 10934..11635 1 NC_009567.1 COG4383 Mu-like prophage protein gp29; hypothetical protein 11635 5227941 CGSHiGG_00090 Haemophilus influenzae PittGG hypothetical protein YP_001291524.1 10934 D 374931 CDS YP_001291525.1 148826772 5227942 11771..12187 1 NC_009567.1 COG5005 Mu-like prophage protein gpG; hypothetical protein 12187 5227942 CGSHiGG_00095 Haemophilus influenzae PittGG hypothetical protein YP_001291525.1 11771 D 374931 CDS YP_001291526.1 148826773 5227943 complement(12561..13358) 1 NC_009567.1 COG3475 LPS biosynthesis protein; lic-1 operon protein 13358 5227943 CGSHiGG_00100 Haemophilus influenzae PittGG lic-1 operon protein YP_001291526.1 12561 R 374931 CDS YP_001291527.1 148826774 5227944 complement(13358..14059) 1 NC_009567.1 COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes; lic-1 operon protein 14059 5227944 CGSHiGG_00105 Haemophilus influenzae PittGG lic-1 operon protein YP_001291527.1 13358 R 374931 CDS YP_001291528.1 148826775 5227945 complement(14056..14934) 1 NC_009567.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; lic-1 operon protein 14934 5227945 CGSHiGG_00110 Haemophilus influenzae PittGG lic-1 operon protein YP_001291528.1 14056 R 374931 CDS YP_001291529.1 148826776 5227946 complement(14934..15914) 1 NC_009567.1 hypothetical protein 15914 5227946 CGSHiGG_00115 Haemophilus influenzae PittGG hypothetical protein YP_001291529.1 14934 R 374931 CDS YP_001291530.1 148826777 5227947 16231..16359 1 NC_009567.1 COG4416 Mu-like prophage protein Com; hypothetical protein 16359 5227947 CGSHiGG_00120 Haemophilus influenzae PittGG hypothetical protein YP_001291530.1 16231 D 374931 CDS YP_001291531.1 148826778 5227948 16426..16962 1 NC_009567.1 COG3101 Uncharacterized protein conserved in bacteria; hypothetical protein 16962 5227948 CGSHiGG_00125 Haemophilus influenzae PittGG hypothetical protein YP_001291531.1 16426 D 374931 CDS YP_001291532.1 148826779 5227949 17164..18360 1 NC_009567.1 Sel1 domain-containing protein 18360 5227949 CGSHiGG_00130 Haemophilus influenzae PittGG Sel1 domain-containing protein YP_001291532.1 17164 D 374931 CDS YP_001291533.1 148826780 5227950 18363..19262 1 NC_009567.1 COG0790 FOG: TPR repeat, SEL1 subfamily; hypothetical protein 19262 5227950 CGSHiGG_00135 Haemophilus influenzae PittGG hypothetical protein YP_001291533.1 18363 D 374931 CDS YP_001291534.1 148826781 5227951 19275..20039 1 NC_009567.1 COG0790 FOG: TPR repeat, SEL1 subfamily; Sel1 repeat-containing protein 20039 5227951 CGSHiGG_00140 Haemophilus influenzae PittGG Sel1 repeat-containing protein YP_001291534.1 19275 D 374931 CDS YP_001291535.1 148826782 5227952 20039..21061 1 NC_009567.1 COG0790 FOG: TPR repeat, SEL1 subfamily; pyruvate kinase 21061 5227952 CGSHiGG_00145 Haemophilus influenzae PittGG pyruvate kinase YP_001291535.1 20039 D 374931 CDS YP_001291536.1 148826783 5227953 21168..22253 1 NC_009567.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 22253 prfA 5227953 prfA Haemophilus influenzae PittGG peptide chain release factor 1 YP_001291536.1 21168 D 374931 CDS YP_001291537.1 148826784 5227954 22306..22746 1 NC_009567.1 COG1714 Predicted membrane protein/domain; hypothetical protein 22746 5227954 CGSHiGG_00155 Haemophilus influenzae PittGG hypothetical protein YP_001291537.1 22306 D 374931 CDS YP_001291538.1 148826785 5227955 22746..23624 1 NC_009567.1 COG2890 Methylase of polypeptide chain release factors; hypothetical protein 23624 5227955 CGSHiGG_00160 Haemophilus influenzae PittGG hypothetical protein YP_001291538.1 22746 D 374931 CDS YP_001291539.1 148826786 5227956 23624..24427 1 NC_009567.1 COG2912 Uncharacterized conserved protein; hypothetical protein 24427 prfA 5227956 prfA Haemophilus influenzae PittGG hypothetical protein YP_001291539.1 23624 D 374931 CDS YP_001291540.1 148826787 5227957 24442..25296 1 NC_009567.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 25296 5227957 CGSHiGG_00170 Haemophilus influenzae PittGG 2-dehydro-3-deoxyphosphooctonate aldolase YP_001291540.1 24442 D 374931 CDS YP_001291541.1 148826788 5227958 25356..26303 1 NC_009567.1 Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor; glycerate dehydrogenase 26303 5227958 CGSHiGG_00175 Haemophilus influenzae PittGG glycerate dehydrogenase YP_001291541.1 25356 D 374931 CDS YP_001291542.1 148826789 5227959 26303..27379 1 NC_009567.1 COG4591 ABC-type transport system, involved in lipoprotein release, permease component; glycerate dehydrogenase 27379 5227959 CGSHiGG_00180 Haemophilus influenzae PittGG glycerate dehydrogenase YP_001291542.1 26303 D 374931 CDS YP_001291543.1 148826790 5227960 27498..28787 1 NC_009567.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine--8-amino-7-oxononanoate transaminase 28787 5227960 CGSHiGG_00185 Haemophilus influenzae PittGG adenosylmethionine--8-amino-7-oxononanoate transaminase YP_001291543.1 27498 D 374931 CDS YP_001291544.1 148826791 5227961 28796..29935 1 NC_009567.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 29935 5227961 CGSHiGG_00190 Haemophilus influenzae PittGG 8-amino-7-oxononanoate synthase YP_001291544.1 28796 D 374931 CDS YP_001291545.1 148826792 5227962 29945..30592 1 NC_009567.1 COG2830 Uncharacterized protein conserved in bacteria; hypothetical protein 30592 5227962 CGSHiGG_00195 Haemophilus influenzae PittGG hypothetical protein YP_001291545.1 29945 D 374931 CDS YP_001291546.1 148826793 5227963 30580..31362 1 NC_009567.1 COG0500 SAM-dependent methyltransferases; 8-amino-7-oxononanoate synthase 31362 5227963 CGSHiGG_00200 Haemophilus influenzae PittGG 8-amino-7-oxononanoate synthase YP_001291546.1 30580 D 374931 CDS YP_001291547.1 148826794 5227964 31372..32013 1 NC_009567.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 32013 bioD 5227964 bioD Haemophilus influenzae PittGG dithiobiotin synthetase YP_001291547.1 31372 D 374931 CDS YP_001291548.1 148826795 5227965 32095..32778 1 NC_009567.1 COG1136 ABC-type antimicrobial peptide transport system, ATPase component; dithiobiotin synthetase 32778 bioD 5227965 bioD Haemophilus influenzae PittGG dithiobiotin synthetase YP_001291548.1 32095 D 374931 CDS YP_001291549.1 148826796 5227849 32778..34028 1 NC_009567.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 34028 5227849 CGSHiGG_00215 Haemophilus influenzae PittGG outer membrane-specific lipoprotein transporter subunit LolE YP_001291549.1 32778 D 374931 CDS YP_001291550.1 148826797 5227850 34246..35334 1 NC_009567.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 35334 5227850 CGSHiGG_00220 Haemophilus influenzae PittGG phospho-2-dehydro-3-deoxyheptonate aldolase YP_001291550.1 34246 D 374931 CDS YP_001291551.1 148826798 5227851 complement(35404..35844) 1 NC_009567.1 hypothetical protein 35844 5227851 CGSHiGG_00225 Haemophilus influenzae PittGG hypothetical protein YP_001291551.1 35404 R 374931 CDS YP_001291552.1 148826799 5227852 36127..37371 1 NC_009567.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 37371 5227852 CGSHiGG_00230 Haemophilus influenzae PittGG serine/threonine transporter SstT YP_001291552.1 36127 D 374931 CDS YP_001291553.1 148826800 5227853 37492..38106 1 NC_009567.1 COG2249 Putative NADPH-quinone reductase (modulator of drug activity B); putative NAD(P)H oxidoreductase 38106 5227853 CGSHiGG_00235 Haemophilus influenzae PittGG putative NAD(P)H oxidoreductase YP_001291553.1 37492 D 374931 CDS YP_001291554.1 148826801 5227854 38099..38653 1 NC_009567.1 COG3381 Uncharacterized component of anaerobic dehydrogenases; putative component of anaerobic dehydrogenase 38653 5227854 CGSHiGG_00240 Haemophilus influenzae PittGG putative component of anaerobic dehydrogenase YP_001291554.1 38099 D 374931 CDS YP_001291555.1 148826802 5227855 complement(38700..39209) 1 NC_009567.1 COG0778 Nitroreductase; nitroreductase 39209 5227855 CGSHiGG_00245 Haemophilus influenzae PittGG nitroreductase YP_001291555.1 38700 R 374931 CDS YP_001291556.1 148826803 5227856 complement(41240..42037) 1 NC_009567.1 COG3475 LPS biosynthesis protein; lic-1 operon protein 42037 5227856 CGSHiGG_00265 Haemophilus influenzae PittGG lic-1 operon protein YP_001291556.1 41240 R 374931 CDS YP_001291557.1 148826804 5227857 complement(42037..42738) 1 NC_009567.1 COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes; lic-1 operon protein 42738 5227857 CGSHiGG_00270 Haemophilus influenzae PittGG lic-1 operon protein YP_001291557.1 42037 R 374931 CDS YP_001291558.1 148826805 5227858 complement(42735..43613) 1 NC_009567.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; lic-1 operon protein 43613 5227858 CGSHiGG_00275 Haemophilus influenzae PittGG lic-1 operon protein YP_001291558.1 42735 R 374931 CDS YP_001291559.1 148826806 5227859 complement(43613..44716) 1 NC_009567.1 COG0510 Predicted choline kinase involved in LPS biosynthesis; phospho-2-dehydro-3-heoxyheptonate aldolase 44716 5227859 CGSHiGG_00280 Haemophilus influenzae PittGG phospho-2-dehydro-3-heoxyheptonate aldolase YP_001291559.1 43613 R 374931 CDS YP_001291560.1 148826807 5227860 complement(44804..46816) 1 NC_009567.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 46816 mnmC 5227860 mnmC Haemophilus influenzae PittGG 5-methylaminomethyl-2-thiouridine methyltransferase YP_001291560.1 44804 R 374931 CDS YP_001291561.1 148826808 5227861 46965..48185 1 NC_009567.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase I 48185 5227861 CGSHiGG_00290 Haemophilus influenzae PittGG 3-oxoacyl-(acyl carrier protein) synthase I YP_001291561.1 46965 D 374931 CDS YP_001291562.1 148826809 5227862 complement(48252..48515) 1 NC_009567.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 1 48515 grxA 5227862 grxA Haemophilus influenzae PittGG glutaredoxin 1 YP_001291562.1 48252 R 374931 CDS YP_001291563.1 148826810 5227863 48630..49538 1 NC_009567.1 COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); ribosomal protein S6 modification protein 49538 5227863 CGSHiGG_00300 Haemophilus influenzae PittGG ribosomal protein S6 modification protein YP_001291563.1 48630 D 374931 CDS YP_001291564.1 148826811 5227864 complement(49577..50791) 1 NC_009567.1 COG0786 Na+/glutamate symporter; glutaredoxin 1 50791 grxA 5227864 grxA Haemophilus influenzae PittGG glutaredoxin 1 YP_001291564.1 49577 R 374931 CDS YP_001291565.1 148826812 5227865 complement(50833..53076) 1 NC_009567.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 53076 5227865 CGSHiGG_00310 Haemophilus influenzae PittGG DNA topoisomerase IV subunit A YP_001291565.1 50833 R 374931 CDS YP_001291566.1 148826813 5227866 complement(55113..56048) 1 NC_009567.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 56048 5227866 CGSHiGG_00325 Haemophilus influenzae PittGG lipid A biosynthesis lauroyl acyltransferase YP_001291566.1 55113 R 374931 CDS YP_001291567.1 148826814 5227867 56145..57575 1 NC_009567.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 57575 5227867 CGSHiGG_00330 Haemophilus influenzae PittGG bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase YP_001291567.1 56145 D 374931 CDS YP_001291568.1 148826815 5227868 complement(57940..58035) 1 NC_009567.1 putative type I restriction enzyme HindVIIP R protein 58035 5227868 CGSHiGG_00335 Haemophilus influenzae PittGG putative type I restriction enzyme HindVIIP R protein YP_001291568.1 57940 R 374931 CDS YP_001291569.1 148826816 5227869 complement(58384..58608) 1 NC_009567.1 COG2870 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 58608 5227869 CGSHiGG_00340 Haemophilus influenzae PittGG bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase YP_001291569.1 58384 R 374931 CDS YP_001291570.1 148826817 5227870 58603..58920 1 NC_009567.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains; ABC transporter ATP-binding protein 58920 5227870 CGSHiGG_00345 Haemophilus influenzae PittGG ABC transporter ATP-binding protein YP_001291570.1 58603 D 374931 CDS YP_001291571.1 148826818 5227871 complement(59766..60905) 1 NC_009567.1 COG0687 Spermidine/putrescine-binding periplasmic protein; ABC transporter ATPase 60905 5227871 CGSHiGG_00360 Haemophilus influenzae PittGG ABC transporter ATPase YP_001291571.1 59766 R 374931 CDS YP_001291572.1 148826819 5227872 complement(60978..61748) 1 NC_009567.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein 61748 potC 5227872 potC Haemophilus influenzae PittGG spermidine/putrescine ABC transporter membrane protein YP_001291572.1 60978 R 374931 CDS YP_001291573.1 148826820 5227873 complement(62591..63709) 1 NC_009567.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase protein 63709 potA 5227873 potA Haemophilus influenzae PittGG putrescine/spermidine ABC transporter ATPase protein YP_001291573.1 62591 R 374931 CDS YP_001291574.1 148826821 5227874 64004..65242 1 NC_009567.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 65242 5227874 CGSHiGG_00385 Haemophilus influenzae PittGG peptidase T YP_001291574.1 64004 D 374931 CDS YP_001291575.1 148826822 5227875 complement(65719..66201) 1 NC_009567.1 COG0783 DNA-binding ferritin-like protein (oxidative damage protectant); peptidase T 66201 5227875 CGSHiGG_00390 Haemophilus influenzae PittGG peptidase T YP_001291575.1 65719 R 374931 CDS YP_001291576.1 148826823 5227876 66474..67352 1 NC_009567.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 67352 5227876 CGSHiGG_00395 Haemophilus influenzae PittGG cytidine deaminase YP_001291576.1 66474 D 374931 CDS YP_001291577.1 148826824 5227877 complement(67395..68360) 1 NC_009567.1 COG0500 SAM-dependent methyltransferases; hypothetical protein 68360 5227877 CGSHiGG_00400 Haemophilus influenzae PittGG hypothetical protein YP_001291577.1 67395 R 374931 CDS YP_001291578.1 148826825 5227878 complement(68357..69871) 1 NC_009567.1 COG0591 Na+/proline symporter; cytidine deaminase 69871 5227878 CGSHiGG_00405 Haemophilus influenzae PittGG cytidine deaminase YP_001291578.1 68357 R 374931 CDS YP_001291579.1 148826826 5227879 72008..73672 1 NC_009567.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 73672 5227879 CGSHiGG_00420 Haemophilus influenzae PittGG glutaminyl-tRNA synthetase YP_001291579.1 72008 D 374931 CDS YP_001291580.1 148826827 5227880 73750..74202 1 NC_009567.1 COG2983 Uncharacterized conserved protein; hypothetical protein 74202 5227880 CGSHiGG_00425 Haemophilus influenzae PittGG hypothetical protein YP_001291580.1 73750 D 374931 CDS YP_001291581.1 148826828 5227881 76372..78564 1 NC_009567.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 78564 5227881 CGSHiGG_00440 Haemophilus influenzae PittGG glycogen branching enzyme YP_001291581.1 76372 D 374931 CDS YP_001291582.1 148826829 5227882 78663..80642 1 NC_009567.1 COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases; glycogen branching enzyme 80642 5227882 CGSHiGG_00445 Haemophilus influenzae PittGG glycogen branching enzyme YP_001291582.1 78663 D 374931 CDS YP_001291583.1 148826830 5227883 80665..81966 1 NC_009567.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 81966 glgC 5227883 glgC Haemophilus influenzae PittGG glucose-1-phosphate adenylyltransferase YP_001291583.1 80665 D 374931 CDS YP_001291584.1 148826831 5227884 82074..83504 1 NC_009567.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 83504 glgA 5227884 glgA Haemophilus influenzae PittGG glycogen synthase YP_001291584.1 82074 D 374931 CDS YP_001291585.1 148826832 5227885 83751..86216 1 NC_009567.1 COG0058 Glucan phosphorylase; glycogen synthase 86216 glgA 5227885 glgA Haemophilus influenzae PittGG glycogen synthase YP_001291585.1 83751 D 374931 CDS YP_001291586.1 148826833 5227886 86477..88015 1 NC_009567.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 88015 pntA 5227886 pntA Haemophilus influenzae PittGG NAD(P) transhydrogenase subunit alpha YP_001291586.1 86477 D 374931 CDS YP_001291587.1 148826834 5227887 88026..89450 1 NC_009567.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 89450 pntB 5227887 pntB Haemophilus influenzae PittGG pyridine nucleotide transhydrogenase YP_001291587.1 88026 D 374931 CDS YP_001291588.1 148826835 5227888 90528..93134 1 NC_009567.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 93134 5227888 CGSHiGG_00485 Haemophilus influenzae PittGG DNA topoisomerase I YP_001291588.1 90528 D 374931 CDS YP_001291589.1 148826836 5227889 complement(93210..93794) 1 NC_009567.1 COG1182 Acyl carrier protein phosphodiesterase; DNA topoisomerase I 93794 5227889 CGSHiGG_00490 Haemophilus influenzae PittGG DNA topoisomerase I YP_001291589.1 93210 R 374931 CDS YP_001291590.1 148826837 5227890 94079..96010 1 NC_009567.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 96010 5227890 CGSHiGG_00495 Haemophilus influenzae PittGG threonyl-tRNA synthetase YP_001291590.1 94079 D 374931 CDS YP_001291591.1 148826838 5227891 complement(96122..98701) 1 NC_009567.1 COG0612 Predicted Zn-dependent peptidases; putative zinc protease 98701 5227891 CGSHiGG_00500 Haemophilus influenzae PittGG putative zinc protease YP_001291591.1 96122 R 374931 CDS YP_001291592.1 148826839 5227892 complement(98670..98915) 1 NC_009567.1 zinc protease 98915 5227892 CGSHiGG_00505 Haemophilus influenzae PittGG zinc protease YP_001291592.1 98670 R 374931 CDS YP_001291593.1 148826840 5227893 complement(101601..101810) 1 NC_009567.1 COG3585 Molybdopterin-binding protein; putative molybdenum-pterin binding protein 101810 5227893 CGSHiGG_00520 Haemophilus influenzae PittGG putative molybdenum-pterin binding protein YP_001291593.1 101601 R 374931 CDS YP_001291594.1 148826841 5227894 complement(101928..102257) 1 NC_009567.1 COG2920 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit; putative dissimilatory sulfite reductase, desulfoviridin subunit gamma 102257 5227894 CGSHiGG_00525 Haemophilus influenzae PittGG putative dissimilatory sulfite reductase, desulfoviridin subunit gamma YP_001291594.1 101928 R 374931 CDS YP_001291595.1 148826842 5227895 103348..104682 1 NC_009567.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 104682 5227895 CGSHiGG_00540 Haemophilus influenzae PittGG condesin subunit F YP_001291595.1 103348 D 374931 CDS YP_001291596.1 148826843 5227896 104695..105651 1 NC_009567.1 modification methylase HaeII 105651 5227896 CGSHiGG_00545 Haemophilus influenzae PittGG modification methylase HaeII YP_001291596.1 104695 D 374931 CDS YP_001291597.1 148826844 5227897 107452..111984 1 NC_009567.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 111984 mukB 5227897 mukB Haemophilus influenzae PittGG cell division protein MukB YP_001291597.1 107452 D 374931 CDS YP_001291598.1 148826845 5227898 112054..112962 1 NC_009567.1 COG3586 Uncharacterized conserved protein; hypothetical protein 112962 5227898 CGSHiGG_00575 Haemophilus influenzae PittGG hypothetical protein YP_001291598.1 112054 D 374931 CDS YP_001291599.1 148826846 5227899 113211..113840 1 NC_009567.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; cell division protein MukB 113840 mukB 5227899 mukB Haemophilus influenzae PittGG cell division protein MukB YP_001291599.1 113211 D 374931 CDS YP_001291600.1 148826847 5227900 113853..115274 1 NC_009567.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 115274 sbcB 5227900 sbcB Haemophilus influenzae PittGG exonuclease I YP_001291600.1 113853 D 374931 CDS YP_001291601.1 148826848 5227901 115682..115969 1 NC_009567.1 hypothetical protein 115969 5227901 CGSHiGG_00590 Haemophilus influenzae PittGG hypothetical protein YP_001291601.1 115682 D 374931 CDS YP_001291602.1 148826849 5227902 complement(115956..116150) 1 NC_009567.1 COG2925 Exonuclease I; hypothetical protein 116150 5227902 CGSHiGG_00595 Haemophilus influenzae PittGG hypothetical protein YP_001291602.1 115956 R 374931 CDS YP_001291603.1 148826850 5227903 complement(116339..116800) 1 NC_009567.1 hypothetical protein 116800 5227903 CGSHiGG_00600 Haemophilus influenzae PittGG hypothetical protein YP_001291603.1 116339 R 374931 CDS YP_001291604.1 148826851 5227904 complement(116797..116982) 1 NC_009567.1 RstR-like phage repressor protein 116982 5227904 CGSHiGG_00605 Haemophilus influenzae PittGG RstR-like phage repressor protein YP_001291604.1 116797 R 374931 CDS YP_001291605.1 148826852 5227905 117135..118283 1 NC_009567.1 hypothetical protein 118283 5227905 CGSHiGG_00610 Haemophilus influenzae PittGG hypothetical protein YP_001291605.1 117135 D 374931 CDS YP_001291606.1 148826853 5227906 118323..118649 1 NC_009567.1 hypothetical protein 118649 5227906 CGSHiGG_00615 Haemophilus influenzae PittGG hypothetical protein YP_001291606.1 118323 D 374931 CDS YP_001291607.1 148826854 5227907 118649..118738 1 NC_009567.1 hypothetical protein 118738 5227907 CGSHiGG_00620 Haemophilus influenzae PittGG hypothetical protein YP_001291607.1 118649 D 374931 CDS YP_001291608.1 148826855 5227908 118735..119007 1 NC_009567.1 hypothetical protein 119007 5227908 CGSHiGG_00625 Haemophilus influenzae PittGG hypothetical protein YP_001291608.1 118735 D 374931 CDS YP_001291609.1 148826856 5227909 119026..119256 1 NC_009567.1 hypothetical protein 119256 5227909 CGSHiGG_00630 Haemophilus influenzae PittGG hypothetical protein YP_001291609.1 119026 D 374931 CDS YP_001291610.1 148826857 5227910 119307..120707 1 NC_009567.1 hypothetical protein 120707 5227910 CGSHiGG_00635 Haemophilus influenzae PittGG hypothetical protein YP_001291610.1 119307 D 374931 CDS YP_001291611.1 148826858 5227911 120716..121012 1 NC_009567.1 COG0181 Porphobilinogen deaminase; putative phage-like membrane protein 121012 5227911 CGSHiGG_00640 Haemophilus influenzae PittGG putative phage-like membrane protein YP_001291611.1 120716 D 374931 CDS YP_001291612.1 148826859 5227912 121016..122056 1 NC_009567.1 COG4128 Zonula occludens toxin; putative phage-like membrane protein 122056 5227912 CGSHiGG_00645 Haemophilus influenzae PittGG putative phage-like membrane protein YP_001291612.1 121016 D 374931 CDS YP_001291613.1 148826860 5227913 122053..123186 1 NC_009567.1 COG1450 Type II secretory pathway, component PulD; putative phage-like secreted protein 123186 5227913 CGSHiGG_00650 Haemophilus influenzae PittGG putative phage-like secreted protein YP_001291613.1 122053 D 374931 CDS YP_001291614.1 148826861 5227914 complement(123991..125268) 1 NC_009567.1 COG0642 Signal transduction histidine kinase; phosphate regulon sensor protein PhoR 125268 5227914 CGSHiGG_00655 Haemophilus influenzae PittGG phosphate regulon sensor protein PhoR YP_001291614.1 123991 R 374931 CDS YP_001291615.1 148826862 5227915 complement(125265..125960) 1 NC_009567.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; phosphate regulon transcriptional regulatory protein PhoB 125960 5227915 CGSHiGG_00660 Haemophilus influenzae PittGG phosphate regulon transcriptional regulatory protein PhoB YP_001291615.1 125265 R 374931 CDS YP_001291616.1 148826863 5227916 complement(126057..126824) 1 NC_009567.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 126824 5227916 CGSHiGG_00665 Haemophilus influenzae PittGG phosphate transporter ATP-binding protein YP_001291616.1 126057 R 374931 CDS YP_001291617.1 148826864 5227917 complement(126834..127682) 1 NC_009567.1 COG0581 ABC-type phosphate transport system, permease component; phosphate transport system permease protein PstA 127682 5227917 CGSHiGG_00670 Haemophilus influenzae PittGG phosphate transport system permease protein PstA YP_001291617.1 126834 R 374931 CDS YP_001291618.1 148826865 5227918 complement(127684..128631) 1 NC_009567.1 COG0573 ABC-type phosphate transport system, permease component; phosphate transport system permease protein PstC 128631 5227918 CGSHiGG_00675 Haemophilus influenzae PittGG phosphate transport system permease protein PstC YP_001291618.1 127684 R 374931 CDS YP_001291619.1 148826866 5227919 complement(128722..129741) 1 NC_009567.1 COG0226 ABC-type phosphate transport system, periplasmic component; phosphate-binding periplasmic protein PstS 129741 5227919 CGSHiGG_00680 Haemophilus influenzae PittGG phosphate-binding periplasmic protein PstS YP_001291619.1 128722 R 374931 CDS YP_001291620.1 148826867 5227920 130243..130731 1 NC_009567.1 COG1528 Ferritin-like protein; ferritin like protein 1 130731 5227920 CGSHiGG_00685 Haemophilus influenzae PittGG ferritin like protein 1 YP_001291620.1 130243 D 374931 CDS YP_001291621.1 148826868 5227921 130747..131244 1 NC_009567.1 COG1528 Ferritin-like protein; ferritin 131244 5227921 CGSHiGG_00690 Haemophilus influenzae PittGG ferritin YP_001291621.1 130747 D 374931 CDS YP_001291622.1 148826869 5227922 131528..133084 1 NC_009567.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 133084 sbcB 5227922 sbcB Haemophilus influenzae PittGG anthranilate synthase component I YP_001291622.1 131528 D 374931 CDS YP_001291623.1 148826870 5227923 133097..133678 1 NC_009567.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 133678 5227923 CGSHiGG_00700 Haemophilus influenzae PittGG anthranilate synthase component II YP_001291623.1 133097 D 374931 CDS YP_001291624.1 148826871 5227924 133727..134113 1 NC_009567.1 COG0512 Anthranilate/para-aminobenzoate synthases component II; anthranilate synthase component II 134113 5227924 CGSHiGG_00705 Haemophilus influenzae PittGG anthranilate synthase component II YP_001291624.1 133727 D 374931 CDS YP_001291625.1 148826872 5227925 134166..135167 1 NC_009567.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 135167 trpD 5227925 trpD Haemophilus influenzae PittGG anthranilate phosphoribosyltransferase YP_001291625.1 134166 D 374931 CDS YP_001291626.1 148826873 5227926 135208..136638 1 NC_009567.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 136638 5227926 CGSHiGG_00715 Haemophilus influenzae PittGG bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase YP_001291626.1 135208 D 374931 CDS YP_001291627.1 148826874 5227927 136700..136972 1 NC_009567.1 COG0298 Hydrogenase maturation factor; hydrogenase 2 accessory protein HypG 136972 5227927 CGSHiGG_00720 Haemophilus influenzae PittGG hydrogenase 2 accessory protein HypG YP_001291627.1 136700 D 374931 CDS YP_001291628.1 148826875 5227966 complement(137004..139868) 1 NC_009567.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 139868 valS 5227966 valS Haemophilus influenzae PittGG valyl-tRNA synthetase YP_001291628.1 137004 R 374931 CDS YP_001291629.1 148826876 5227967 complement(140096..140320) 1 NC_009567.1 hypothetical protein 140320 5227967 CGSHiGG_00730 Haemophilus influenzae PittGG hypothetical protein YP_001291629.1 140096 R 374931 CDS YP_001291630.1 148826877 5227968 complement(140364..140447) 1 NC_009567.1 hypothetical protein 140447 5227968 CGSHiGG_00735 Haemophilus influenzae PittGG hypothetical protein YP_001291630.1 140364 R 374931 CDS YP_001291631.1 148826878 5227969 complement(140524..141177) 1 NC_009567.1 COG0525 Valyl-tRNA synthetase; hypothetical protein 141177 5227969 CGSHiGG_00740 Haemophilus influenzae PittGG hypothetical protein YP_001291631.1 140524 R 374931 CDS YP_001291632.1 148826879 5227970 complement(141178..141483) 1 NC_009567.1 COG3097 Uncharacterized protein conserved in bacteria; hypothetical protein 141483 valS 5227970 valS Haemophilus influenzae PittGG hypothetical protein YP_001291632.1 141178 R 374931 CDS YP_001291633.1 148826880 5227971 complement(141487..141921) 1 NC_009567.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 141921 5227971 CGSHiGG_00750 Haemophilus influenzae PittGG DNA polymerase III subunit chi YP_001291633.1 141487 R 374931 CDS YP_001291634.1 148826881 5227972 142156..143550 1 NC_009567.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 143550 fumC 5227972 fumC Haemophilus influenzae PittGG fumarate hydratase YP_001291634.1 142156 D 374931 CDS YP_001291635.1 148826882 5227973 143678..144286 1 NC_009567.1 COG0114 Fumarase; hypothetical protein 144286 5227973 CGSHiGG_00760 Haemophilus influenzae PittGG hypothetical protein YP_001291635.1 143678 D 374931 CDS YP_001291636.1 148826883 5227974 complement(144385..145209) 1 NC_009567.1 COG0613 Predicted metal-dependent phosphoesterases (PHP family); fumarate hydratase 145209 fumC 5227974 fumC Haemophilus influenzae PittGG fumarate hydratase YP_001291636.1 144385 R 374931 CDS YP_001291637.1 148826884 5227975 complement(145209..146228) 1 NC_009567.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 146228 5227975 CGSHiGG_00770 Haemophilus influenzae PittGG dihydroorotate dehydrogenase 2 YP_001291637.1 145209 R 374931 CDS YP_001291638.1 148826885 5227976 complement(147366..147821) 1 NC_009567.1 COG1855 ATPase (PilT family); hypothetical protein 147821 5227976 CGSHiGG_00785 Haemophilus influenzae PittGG hypothetical protein YP_001291638.1 147366 R 374931 CDS YP_001291639.1 148826886 5227977 complement(147834..148934) 1 NC_009567.1 COG3566 Uncharacterized protein conserved in bacteria; hypothetical protein 148934 5227977 CGSHiGG_00790 Haemophilus influenzae PittGG hypothetical protein YP_001291639.1 147834 R 374931 CDS YP_001291640.1 148826887 5227978 complement(149075..150358) 1 NC_009567.1 COG2369 Uncharacterized protein, homolog of phage Mu protein gp30; hypothetical protein 150358 5227978 CGSHiGG_00795 Haemophilus influenzae PittGG hypothetical protein YP_001291640.1 149075 R 374931 CDS YP_001291641.1 148826888 5227979 complement(151863..152963) 1 NC_009567.1 COG1783 Phage terminase large subunit; phage terminase large subunit 152963 5227979 CGSHiGG_00810 Haemophilus influenzae PittGG phage terminase large subunit YP_001291641.1 151863 R 374931 CDS YP_001291642.1 148826889 5227980 complement(152950..153465) 1 NC_009567.1 COG3728 Phage terminase, small subunit; terminase small subunit 153465 5227980 CGSHiGG_00815 Haemophilus influenzae PittGG terminase small subunit YP_001291642.1 152950 R 374931 CDS YP_001291643.1 148826890 5227981 153510..153788 1 NC_009567.1 hypothetical protein 153788 5227981 CGSHiGG_00820 Haemophilus influenzae PittGG hypothetical protein YP_001291643.1 153510 D 374931 CDS YP_001291644.1 148826891 5227982 complement(153790..154071) 1 NC_009567.1 hypothetical protein 154071 5227982 CGSHiGG_00825 Haemophilus influenzae PittGG hypothetical protein YP_001291644.1 153790 R 374931 CDS YP_001291645.1 148826892 5227983 complement(154157..154306) 1 NC_009567.1 COG1396 Predicted transcriptional regulators; hypothetical protein 154306 5227983 CGSHiGG_00830 Haemophilus influenzae PittGG hypothetical protein YP_001291645.1 154157 R 374931 CDS YP_001291646.1 148826893 5227984 complement(154299..154892) 1 NC_009567.1 hypothetical protein 154892 5227984 CGSHiGG_00835 Haemophilus influenzae PittGG hypothetical protein YP_001291646.1 154299 R 374931 CDS YP_001291647.1 148826894 5227985 complement(154870..155226) 1 NC_009567.1 COG3179 Predicted chitinase; hypothetical protein 155226 5227985 CGSHiGG_00840 Haemophilus influenzae PittGG hypothetical protein YP_001291647.1 154870 R 374931 CDS YP_001291648.1 148826895 5227986 complement(155449..156303) 1 NC_009567.1 COG3617 Prophage antirepressor; putative antirepressor protein 156303 5227986 CGSHiGG_00845 Haemophilus influenzae PittGG putative antirepressor protein YP_001291648.1 155449 R 374931 CDS YP_001291649.1 148826896 5227987 complement(156616..157074) 1 NC_009567.1 COG1196 Chromosome segregation ATPases; hypothetical protein 157074 5227987 CGSHiGG_00850 Haemophilus influenzae PittGG hypothetical protein YP_001291649.1 156616 R 374931 CDS YP_001291650.1 148826897 5227988 complement(157184..157723) 1 NC_009567.1 hypothetical protein 157723 5227988 CGSHiGG_00855 Haemophilus influenzae PittGG hypothetical protein YP_001291650.1 157184 R 374931 CDS YP_001291651.1 148826898 5227989 complement(157901..158269) 1 NC_009567.1 hypothetical protein 158269 5227989 CGSHiGG_00860 Haemophilus influenzae PittGG hypothetical protein YP_001291651.1 157901 R 374931 CDS YP_001291652.1 148826899 5227990 complement(158332..158913) 1 NC_009567.1 hypothetical protein 158913 5227990 CGSHiGG_00865 Haemophilus influenzae PittGG hypothetical protein YP_001291652.1 158332 R 374931 CDS YP_001291653.1 148826900 5227991 complement(158960..159526) 1 NC_009567.1 hypothetical protein 159526 5227991 CGSHiGG_00870 Haemophilus influenzae PittGG hypothetical protein YP_001291653.1 158960 R 374931 CDS YP_001291654.1 148826901 5227992 complement(159526..159618) 1 NC_009567.1 hypothetical protein 159618 5227992 CGSHiGG_00875 Haemophilus influenzae PittGG hypothetical protein YP_001291654.1 159526 R 374931 CDS YP_001291655.1 148826902 5227993 complement(159615..159983) 1 NC_009567.1 putative recombination protein NinB 159983 5227993 CGSHiGG_00880 Haemophilus influenzae PittGG putative recombination protein NinB YP_001291655.1 159615 R 374931 CDS YP_001291656.1 148826903 5227994 complement(160070..160294) 1 NC_009567.1 hypothetical protein 160294 5227994 CGSHiGG_00885 Haemophilus influenzae PittGG hypothetical protein YP_001291656.1 160070 R 374931 CDS YP_001291657.1 148826904 5227995 complement(160281..160931) 1 NC_009567.1 hypothetical protein 160931 5227995 CGSHiGG_00890 Haemophilus influenzae PittGG hypothetical protein YP_001291657.1 160281 R 374931 CDS YP_001291658.1 148826905 5227996 complement(160928..161674) 1 NC_009567.1 hypothetical protein 161674 5227996 CGSHiGG_00895 Haemophilus influenzae PittGG hypothetical protein YP_001291658.1 160928 R 374931 CDS YP_001291659.1 148826906 5227997 complement(161671..162339) 1 NC_009567.1 hypothetical protein 162339 5227997 CGSHiGG_00900 Haemophilus influenzae PittGG hypothetical protein YP_001291659.1 161671 R 374931 CDS YP_001291660.1 148826907 5227998 complement(162386..162733) 1 NC_009567.1 hypothetical protein 162733 5227998 CGSHiGG_00905 Haemophilus influenzae PittGG hypothetical protein YP_001291660.1 162386 R 374931 CDS YP_001291661.1 148826908 5227999 complement(162751..162825) 1 NC_009567.1 COG3646 Uncharacterized phage-encoded protein; hypothetical protein 162825 5227999 CGSHiGG_00910 Haemophilus influenzae PittGG hypothetical protein YP_001291661.1 162751 R 374931 CDS YP_001291662.1 148826909 5228000 complement(162874..163062) 1 NC_009567.1 COG4197 Uncharacterized protein conserved in bacteria, prophage-related; hypothetical protein 163062 5228000 CGSHiGG_00915 Haemophilus influenzae PittGG hypothetical protein YP_001291662.1 162874 R 374931 CDS YP_001291663.1 148826910 5228001 163231..163872 1 NC_009567.1 transcriptional regulator 163872 5228001 CGSHiGG_00920 Haemophilus influenzae PittGG transcriptional regulator YP_001291663.1 163231 D 374931 CDS YP_001291664.1 148826911 5228002 163927..165009 1 NC_009567.1 hypothetical protein 165009 5228002 CGSHiGG_00925 Haemophilus influenzae PittGG hypothetical protein YP_001291664.1 163927 D 374931 CDS YP_001291665.1 148826912 5228003 complement(164936..165592) 1 NC_009567.1 COG2932 Predicted transcriptional regulator; hypothetical protein 165592 5228003 CGSHiGG_00930 Haemophilus influenzae PittGG hypothetical protein YP_001291665.1 164936 R 374931 CDS YP_001291666.1 148826913 5228004 complement(166026..166196) 1 NC_009567.1 hypothetical protein 166196 5228004 CGSHiGG_00935 Haemophilus influenzae PittGG hypothetical protein YP_001291666.1 166026 R 374931 CDS YP_001291667.1 148826914 5228005 166211..166432 1 NC_009567.1 hypothetical protein 166432 5228005 CGSHiGG_00940 Haemophilus influenzae PittGG hypothetical protein YP_001291667.1 166211 D 374931 CDS YP_001291668.1 148826915 5228006 166600..166920 1 NC_009567.1 hypothetical protein 166920 5228006 CGSHiGG_00945 Haemophilus influenzae PittGG hypothetical protein YP_001291668.1 166600 D 374931 CDS YP_001291669.1 148826916 5228007 complement(166898..167101) 1 NC_009567.1 hypothetical protein 167101 5228007 CGSHiGG_00950 Haemophilus influenzae PittGG hypothetical protein YP_001291669.1 166898 R 374931 CDS YP_001291670.1 148826917 5228008 167702..167947 1 NC_009567.1 COG3422 Uncharacterized conserved protein; hypothetical protein 167947 5228008 CGSHiGG_00955 Haemophilus influenzae PittGG hypothetical protein YP_001291670.1 167702 D 374931 CDS YP_001291671.1 148826918 5228009 168003..168974 1 NC_009567.1 COG0419 ATPase involved in DNA repair; hypothetical protein 168974 5228009 CGSHiGG_00960 Haemophilus influenzae PittGG hypothetical protein YP_001291671.1 168003 D 374931 CDS YP_001291672.1 148826919 5228010 169312..169563 1 NC_009567.1 phage anti-repressor protein 169563 5228010 CGSHiGG_00965 Haemophilus influenzae PittGG phage anti-repressor protein YP_001291672.1 169312 D 374931 CDS YP_001291673.1 148826920 5228011 169708..169827 1 NC_009567.1 hypothetical protein 169827 5228011 CGSHiGG_00970 Haemophilus influenzae PittGG hypothetical protein YP_001291673.1 169708 D 374931 CDS YP_001291674.1 148826921 5228012 169869..170156 1 NC_009567.1 COG3561 Phage anti-repressor protein; hypothetical protein 170156 5228012 CGSHiGG_00975 Haemophilus influenzae PittGG hypothetical protein YP_001291674.1 169869 D 374931 CDS YP_001291675.1 148826922 5228013 complement(170153..170812) 1 NC_009567.1 COG0582 Integrase; integrase/recombinase 170812 5228013 CGSHiGG_00980 Haemophilus influenzae PittGG integrase/recombinase YP_001291675.1 170153 R 374931 CDS YP_001291676.1 148826923 5228014 complement(170831..171049) 1 NC_009567.1 dihydroorotate dehydrogenase 2 171049 5228014 CGSHiGG_00985 Haemophilus influenzae PittGG dihydroorotate dehydrogenase 2 YP_001291676.1 170831 R 374931 CDS YP_001291677.1 148826924 5228015 complement(171418..171483) 1 NC_009567.1 COG0582 Integrase; hypothetical protein 171483 5228015 CGSHiGG_00990 Haemophilus influenzae PittGG hypothetical protein YP_001291677.1 171418 R 374931 CDS YP_001291678.1 148826925 5228016 171575..172348 1 NC_009567.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 172348 5228016 CGSHiGG_00995 Haemophilus influenzae PittGG fumarate/nitrate reduction transcriptional regulator YP_001291678.1 171575 D 374931 CDS YP_001291679.1 148826926 5228017 172377..173399 1 NC_009567.1 with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 173399 5228017 CGSHiGG_01000 Haemophilus influenzae PittGG universal stress protein UspE YP_001291679.1 172377 D 374931 CDS YP_001291680.1 148826927 5228018 173596..174432 1 NC_009567.1 COG5266 ABC-type Co2+ transport system, periplasmic component; universal stress protein UspE 174432 5228018 CGSHiGG_01005 Haemophilus influenzae PittGG universal stress protein UspE YP_001291680.1 173596 D 374931 CDS YP_001291681.1 148826928 5228019 complement(174516..175154) 1 NC_009567.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 175154 purN 5228019 purN Haemophilus influenzae PittGG phosphoribosylglycinamide formyltransferase YP_001291681.1 174516 R 374931 CDS YP_001291682.1 148826929 5228020 complement(175209..176243) 1 NC_009567.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 176243 5228020 CGSHiGG_01015 Haemophilus influenzae PittGG phosphoribosylaminoimidazole synthetase YP_001291682.1 175209 R 374931 CDS YP_001291683.1 148826930 5228021 176472..177182 1 NC_009567.1 COG4221 Short-chain alcohol dehydrogenase of unknown specificity; phosphoribosylaminoimidazole synthetase 177182 5228021 CGSHiGG_01020 Haemophilus influenzae PittGG phosphoribosylaminoimidazole synthetase YP_001291683.1 176472 D 374931 CDS YP_001291684.1 148826931 5228022 177199..178395 1 NC_009567.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 178395 5228022 CGSHiGG_01025 Haemophilus influenzae PittGG tryptophan synthase subunit beta YP_001291684.1 177199 D 374931 CDS YP_001291685.1 148826932 5228023 178395..179201 1 NC_009567.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 179201 trpA 5228023 trpA Haemophilus influenzae PittGG tryptophan synthase subunit alpha YP_001291685.1 178395 D 374931 CDS YP_001291686.1 148826933 5228024 complement(179341..180294) 1 NC_009567.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 180294 5228024 CGSHiGG_01035 Haemophilus influenzae PittGG aspartate-semialdehyde dehydrogenase YP_001291686.1 179341 R 374931 CDS YP_001291687.1 148826934 5228025 180353..180829 1 NC_009567.1 COG2606 Uncharacterized conserved protein; hypothetical protein 180829 5228025 CGSHiGG_01040 Haemophilus influenzae PittGG hypothetical protein YP_001291687.1 180353 D 374931 CDS YP_001291688.1 148826935 5228026 complement(180984..181202) 1 NC_009567.1 COG1278 Cold shock proteins; aspartate-semialdehyde dehydrogenase 181202 5228026 CGSHiGG_01045 Haemophilus influenzae PittGG aspartate-semialdehyde dehydrogenase YP_001291688.1 180984 R 374931 CDS YP_001291689.1 148826936 5228027 complement(181351..181509) 1 NC_009567.1 COG3140 Uncharacterized protein conserved in bacteria; hypothetical protein 181509 5228027 CGSHiGG_01050 Haemophilus influenzae PittGG hypothetical protein YP_001291689.1 181351 R 374931 CDS YP_001291690.1 148826937 5228028 complement(181502..182221) 1 NC_009567.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C 182221 5228028 CGSHiGG_01055 Haemophilus influenzae PittGG tRNA pseudouridine synthase C YP_001291690.1 181502 R 374931 CDS YP_001291691.1 148826938 5228029 complement(182215..182535) 1 NC_009567.1 COG3098 Uncharacterized protein conserved in bacteria; hypothetical protein 182535 5228029 CGSHiGG_01060 Haemophilus influenzae PittGG hypothetical protein YP_001291691.1 182215 R 374931 CDS YP_001291692.1 148826939 5228030 complement(182550..184007) 1 NC_009567.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 184007 5228030 CGSHiGG_01065 Haemophilus influenzae PittGG thiamine biosynthesis protein ThiI YP_001291692.1 182550 R 374931 CDS YP_001291693.1 148826940 5228031 184166..184405 1 NC_009567.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 184405 5228031 CGSHiGG_01070 Haemophilus influenzae PittGG exodeoxyribonuclease VII small subunit YP_001291693.1 184166 D 374931 CDS YP_001291694.1 148826941 5228032 184405..185295 1 NC_009567.1 COG0142 Geranylgeranyl pyrophosphate synthase; exodeoxyribonuclease VII small subunit 185295 5228032 CGSHiGG_01075 Haemophilus influenzae PittGG exodeoxyribonuclease VII small subunit YP_001291694.1 184405 D 374931 CDS YP_001291695.1 148826942 5228033 185337..187214 1 NC_009567.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 187214 5228033 CGSHiGG_01080 Haemophilus influenzae PittGG 1-deoxy-D-xylulose-5-phosphate synthase YP_001291695.1 185337 D 374931 CDS YP_001291696.1 148826943 5228034 complement(187250..187702) 1 NC_009567.1 COG2969 Stringent starvation protein B; ClpXP protease specificity-enhancing factor 187702 5228034 CGSHiGG_01085 Haemophilus influenzae PittGG ClpXP protease specificity-enhancing factor YP_001291696.1 187250 R 374931 CDS YP_001291697.1 148826944 5228035 complement(187702..188340) 1 NC_009567.1 COG0625 Glutathione S-transferase; ClpXP protease specificity-enhancing factor 188340 5228035 CGSHiGG_01090 Haemophilus influenzae PittGG ClpXP protease specificity-enhancing factor YP_001291697.1 187702 R 374931 CDS YP_001291698.1 148826945 5228036 complement(188521..188913) 1 NC_009567.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 188913 rpsI 5228036 rpsI Haemophilus influenzae PittGG 30S ribosomal protein S9 YP_001291698.1 188521 R 374931 CDS YP_001291699.1 148826946 5228037 complement(188930..189358) 1 NC_009567.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 189358 rplM 5228037 rplM Haemophilus influenzae PittGG 50S ribosomal protein L13 YP_001291699.1 188930 R 374931 CDS YP_001291700.1 148826947 5228038 189822..190700 1 NC_009567.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 190700 metF 5228038 metF Haemophilus influenzae PittGG 5,10-methylenetetrahydrofolate reductase YP_001291700.1 189822 D 374931 CDS YP_001291701.1 148826948 5228039 complement(190790..191518) 1 NC_009567.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 191518 bioD 5228039 bioD Haemophilus influenzae PittGG dithiobiotin synthetase YP_001291701.1 190790 R 374931 CDS YP_001291702.1 148826949 5228040 complement(191621..191887) 1 NC_009567.1 COG3100 Uncharacterized protein conserved in bacteria; dithiobiotin synthetase 191887 bioD 5228040 bioD Haemophilus influenzae PittGG dithiobiotin synthetase YP_001291702.1 191621 R 374931 CDS YP_001291703.1 148826950 5228041 complement(191948..192604) 1 NC_009567.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 192604 folE 5228041 folE Haemophilus influenzae PittGG GTP cyclohydrolase I YP_001291703.1 191948 R 374931 CDS YP_001291704.1 148826951 5228042 192742..193956 1 NC_009567.1 COG0303 Molybdopterin biosynthesis enzyme; GTP cyclohydrolase I 193956 folE 5228042 folE Haemophilus influenzae PittGG GTP cyclohydrolase I YP_001291704.1 192742 D 374931 CDS YP_001291705.1 148826952 5228043 193960..194691 1 NC_009567.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 194691 5228043 CGSHiGG_01130 Haemophilus influenzae PittGG molybdopterin biosynthesis protein MoeB YP_001291705.1 193960 D 374931 CDS YP_001291706.1 148826953 5228044 194758..195081 1 NC_009567.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 195081 5228044 CGSHiGG_01135 Haemophilus influenzae PittGG dsDNA-mimic protein YP_001291706.1 194758 D 374931 CDS YP_001291707.1 148826954 5228045 complement(195138..195665) 1 NC_009567.1 COG0526 Thiol-disulfide isomerase and thioredoxins; phosphoribosylformylglycinamidine synthase 195665 5228045 CGSHiGG_01140 Haemophilus influenzae PittGG phosphoribosylformylglycinamidine synthase YP_001291707.1 195138 R 374931 CDS YP_001291708.1 148826955 5228046 complement(195708..196349) 1 NC_009567.1 COG0785 Cytochrome c biogenesis protein; hypothetical protein 196349 5228046 CGSHiGG_01145 Haemophilus influenzae PittGG hypothetical protein YP_001291708.1 195708 R 374931 CDS YP_001291709.1 148826956 5228047 complement(196361..197422) 1 NC_009567.1 COG0225 Peptide methionine sulfoxide reductase; bifunctional methionine sulfoxide reductase A/B protein 197422 5228047 CGSHiGG_01150 Haemophilus influenzae PittGG bifunctional methionine sulfoxide reductase A/B protein YP_001291709.1 196361 R 374931 CDS YP_001291710.1 148826957 5228048 197596..198459 1 NC_009567.1 hypothetical protein 198459 5228048 CGSHiGG_01155 Haemophilus influenzae PittGG hypothetical protein YP_001291710.1 197596 D 374931 CDS YP_001291711.1 148826958 5228049 complement(198554..198727) 1 NC_009567.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; dsDNA-mimic protein 198727 5228049 CGSHiGG_01160 Haemophilus influenzae PittGG dsDNA-mimic protein YP_001291711.1 198554 R 374931 CDS YP_001291712.1 148826959 5228050 complement(198736..199281) 1 NC_009567.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor 199281 5228050 CGSHiGG_01165 Haemophilus influenzae PittGG RNA polymerase sigma factor YP_001291712.1 198736 R 374931 CDS YP_001291713.1 148826960 5228051 complement(199408..199557) 1 NC_009567.1 hypothetical protein 199557 5228051 CGSHiGG_01170 Haemophilus influenzae PittGG hypothetical protein YP_001291713.1 199408 R 374931 CDS YP_001291714.1 148826961 5228052 complement(199641..199793) 1 NC_009567.1 hypothetical protein 199793 5228052 CGSHiGG_01175 Haemophilus influenzae PittGG hypothetical protein YP_001291714.1 199641 R 374931 CDS YP_001291715.1 148826962 5228053 complement(199816..199923) 1 NC_009567.1 COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; hypothetical protein 199923 5228053 CGSHiGG_01180 Haemophilus influenzae PittGG hypothetical protein YP_001291715.1 199816 R 374931 CDS YP_001291716.1 148826963 5226806 200150..201514 1 NC_009567.1 COG1538 Outer membrane protein; hypothetical protein 201514 5226806 CGSHiGG_01185 Haemophilus influenzae PittGG hypothetical protein YP_001291716.1 200150 D 374931 CDS YP_001291717.1 148826964 5226807 complement(202334..202828) 1 NC_009567.1 COG2062 Phosphohistidine phosphatase SixA; hypothetical protein 202828 5226807 CGSHiGG_01200 Haemophilus influenzae PittGG hypothetical protein YP_001291717.1 202334 R 374931 CDS YP_001291718.1 148826965 5226808 complement(204260..205087) 1 NC_009567.1 COG0294 Dihydropteroate synthase and related enzymes; dihydropteroate synthase 205087 5226808 CGSHiGG_01215 Haemophilus influenzae PittGG dihydropteroate synthase YP_001291718.1 204260 R 374931 CDS YP_001291719.1 148826966 5226809 complement(205199..207106) 1 NC_009567.1 COG0465 ATP-dependent Zn proteases; RNA polymerase sigma factor 207106 5226809 CGSHiGG_01220 Haemophilus influenzae PittGG RNA polymerase sigma factor YP_001291719.1 205199 R 374931 CDS YP_001291720.1 148826967 5226810 complement(207197..207784) 1 NC_009567.1 COG0293 23S rRNA methylase; cell division protein 207784 5226810 CGSHiGG_01225 Haemophilus influenzae PittGG cell division protein YP_001291720.1 207197 R 374931 CDS YP_001291721.1 148826968 5226811 207954..208253 1 NC_009567.1 COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein; 23S rRNA methyltransferase J 208253 rrmJ 5226811 rrmJ Haemophilus influenzae PittGG 23S rRNA methyltransferase J YP_001291721.1 207954 D 374931 CDS YP_001291722.1 148826969 5226812 complement(208292..208768) 1 NC_009567.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 208768 greA 5226812 greA Haemophilus influenzae PittGG transcription elongation factor GreA YP_001291722.1 208292 R 374931 CDS YP_001291723.1 148826970 5226813 complement(210687..210956) 1 NC_009567.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 210956 rpsO 5226813 rpsO Haemophilus influenzae PittGG 30S ribosomal protein S15 YP_001291723.1 210687 R 374931 CDS YP_001291724.1 148826971 5226814 complement(211092..211223) 1 NC_009567.1 hypothetical protein 211223 5226814 CGSHiGG_01255 Haemophilus influenzae PittGG hypothetical protein YP_001291724.1 211092 R 374931 CDS YP_001291725.1 148826972 5226815 complement(211223..211948) 1 NC_009567.1 COG0184 Ribosomal protein S15P/S13E; 30S ribosomal protein S15 211948 rpsO 5226815 rpsO Haemophilus influenzae PittGG 30S ribosomal protein S15 YP_001291725.1 211223 R 374931 CDS YP_001291726.1 148826973 5226816 complement(212185..212718) 1 NC_009567.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-(acyl carrier protein) dehydratase 212718 5226816 CGSHiGG_01265 Haemophilus influenzae PittGG 3-hydroxydecanoyl-(acyl carrier protein) dehydratase YP_001291726.1 212185 R 374931 CDS YP_001291727.1 148826974 5226817 complement(212889..214664) 1 NC_009567.1 COG1067 Predicted ATP-dependent protease; 3-hydroxydecanoyl-ACP dehydratase 214664 5226817 CGSHiGG_01270 Haemophilus influenzae PittGG 3-hydroxydecanoyl-ACP dehydratase YP_001291727.1 212889 R 374931 CDS YP_001291728.1 148826975 5226818 214791..215237 1 NC_009567.1 COG3120 Uncharacterized protein conserved in bacteria; hypothetical protein 215237 5226818 CGSHiGG_01275 Haemophilus influenzae PittGG hypothetical protein YP_001291728.1 214791 D 374931 CDS YP_001291729.1 148826976 5226819 complement(215305..217227) 1 NC_009567.1 COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member; exodeoxyribonuclease V subunit alpha 217227 5226819 CGSHiGG_01280 Haemophilus influenzae PittGG exodeoxyribonuclease V subunit alpha YP_001291729.1 215305 R 374931 CDS YP_001291730.1 148826977 5226820 complement(220977..221330) 1 NC_009567.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 221330 rplT 5226820 rplT Haemophilus influenzae PittGG 50S ribosomal protein L20 YP_001291730.1 220977 R 374931 CDS YP_001291731.1 148826978 5226821 complement(221396..221665) 1 NC_009567.1 COG0291 Ribosomal protein L35; 50S ribosomal protein L35 221665 rpmI 5226821 rpmI Haemophilus influenzae PittGG 50S ribosomal protein L35 YP_001291731.1 221396 R 374931 CDS YP_001291732.1 148826979 5226822 complement(221804..222073) 1 NC_009567.1 COG0290 Translation initiation factor 3 (IF-3); translation initiation factor IF-3 222073 5226822 CGSHiGG_01305 Haemophilus influenzae PittGG translation initiation factor IF-3 YP_001291732.1 221804 R 374931 CDS YP_001291733.1 148826980 5226823 complement(222482..223294) 1 NC_009567.1 related to aldose 1-epimerase; COG0676 Uncharacterized enzymes related to aldose 1-epimerase; hypothetical protein 223294 5226823 CGSHiGG_01310 Haemophilus influenzae PittGG hypothetical protein YP_001291733.1 222482 R 374931 CDS YP_001291734.1 148826981 5226824 complement(223379..223816) 1 NC_009567.1 COG3119 Arylsulfatase A and related enzymes; arylsulfatase A-like enzyme 223816 5226824 CGSHiGG_01315 Haemophilus influenzae PittGG arylsulfatase A-like enzyme YP_001291734.1 223379 R 374931 CDS YP_001291735.1 148826982 5226825 complement(223836..225887) 1 NC_009567.1 COG0464 ATPases of the AAA+ class; serine/threonine protein phosphatase family protein 225887 5226825 CGSHiGG_01320 Haemophilus influenzae PittGG serine/threonine protein phosphatase family protein YP_001291735.1 223836 R 374931 CDS YP_001291736.1 148826983 5226826 complement(227916..229247) 1 NC_009567.1 COG1479 Uncharacterized conserved protein; hypothetical protein 229247 5226826 CGSHiGG_01335 Haemophilus influenzae PittGG hypothetical protein YP_001291736.1 227916 R 374931 CDS YP_001291737.1 148826984 5226827 complement(229284..230036) 1 NC_009567.1 COG0631 Serine/threonine protein phosphatase; hypothetical protein 230036 5226827 CGSHiGG_01340 Haemophilus influenzae PittGG hypothetical protein YP_001291737.1 229284 R 374931 CDS YP_001291738.1 148826985 5226828 complement(230047..230880) 1 NC_009567.1 COG0846 NAD-dependent protein deacetylases, SIR2 family; NAD-dependent deacetylase sirtuin 5 230880 5226828 CGSHiGG_01345 Haemophilus influenzae PittGG NAD-dependent deacetylase sirtuin 5 YP_001291738.1 230047 R 374931 CDS YP_001291739.1 148826986 5226829 complement(230877..231077) 1 NC_009567.1 COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins; DNA translocase FtsK 231077 5226829 CGSHiGG_01350 Haemophilus influenzae PittGG DNA translocase FtsK YP_001291739.1 230877 R 374931 CDS YP_001291740.1 148826987 5226830 complement(232107..232766) 1 NC_009567.1 COG0846 NAD-dependent protein deacetylases, SIR2 family; NAD-dependent deacetylase 232766 5226830 CGSHiGG_01365 Haemophilus influenzae PittGG NAD-dependent deacetylase YP_001291740.1 232107 R 374931 CDS YP_001291741.1 148826988 5226831 complement(232750..233205) 1 NC_009567.1 COG4502 Uncharacterized protein conserved in bacteria; putative 5'(3')-deoxyribonucleotidase 233205 5226831 CGSHiGG_01370 Haemophilus influenzae PittGG putative 5'(3')-deoxyribonucleotidase YP_001291741.1 232750 R 374931 CDS YP_001291742.1 148826989 5226832 complement(233264..234034) 1 NC_009567.1 hypothetical protein 234034 5226832 CGSHiGG_01375 Haemophilus influenzae PittGG hypothetical protein YP_001291742.1 233264 R 374931 CDS YP_001291743.1 148826990 5226833 complement(234070..234273) 1 NC_009567.1 COG2378 Predicted transcriptional regulator; hypothetical protein 234273 5226833 CGSHiGG_01380 Haemophilus influenzae PittGG hypothetical protein YP_001291743.1 234070 R 374931 CDS YP_001291744.1 148826991 5226834 complement(234282..234767) 1 NC_009567.1 COG0791 Cell wall-associated hydrolases (invasion-associated proteins); lipoprotein 234767 5226834 CGSHiGG_01385 Haemophilus influenzae PittGG lipoprotein YP_001291744.1 234282 R 374931 CDS YP_001291745.1 148826992 5226835 complement(234820..235110) 1 NC_009567.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 235110 ihfA 5226835 ihfA Haemophilus influenzae PittGG integration host factor subunit alpha YP_001291745.1 234820 R 374931 CDS YP_001291746.1 148826993 5226836 complement(235112..237499) 1 NC_009567.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 237499 pheT 5226836 pheT Haemophilus influenzae PittGG phenylalanyl-tRNA synthetase subunit beta YP_001291746.1 235112 R 374931 CDS YP_001291747.1 148826994 5226837 complement(238670..239410) 1 NC_009567.1 COG0016 Phenylalanyl-tRNA synthetase alpha subunit; hypothetical protein 239410 5226837 CGSHiGG_01410 Haemophilus influenzae PittGG hypothetical protein YP_001291747.1 238670 R 374931 CDS YP_001291748.1 148826995 5226838 239456..239704 1 NC_009567.1 COG0633 Ferredoxin; phenylalanyl-tRNA synthetase subunit alpha 239704 pheS 5226838 pheS Haemophilus influenzae PittGG phenylalanyl-tRNA synthetase subunit alpha YP_001291748.1 239456 D 374931 CDS YP_001291749.1 148826996 5226839 complement(239699..240511) 1 NC_009567.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 240511 5226839 CGSHiGG_01420 Haemophilus influenzae PittGG dihydrodipicolinate reductase YP_001291749.1 239699 R 374931 CDS YP_001291750.1 148826997 5226840 complement(240528..241157) 1 NC_009567.1 COG1280 Putative threonine efflux protein; hypothetical protein 241157 5226840 CGSHiGG_01425 Haemophilus influenzae PittGG hypothetical protein YP_001291750.1 240528 R 374931 CDS YP_001291751.1 148826998 5226841 complement(241157..241648) 1 NC_009567.1 COG1267 Phosphatidylglycerophosphatase A and related proteins; phosphatidylglycerophosphatase A 241648 5226841 CGSHiGG_01430 Haemophilus influenzae PittGG phosphatidylglycerophosphatase A YP_001291751.1 241157 R 374931 CDS YP_001291752.1 148826999 5226842 complement(241645..242631) 1 NC_009567.1 COG0611 Thiamine monophosphate kinase; dihydrodipicolinate reductase 242631 5226842 CGSHiGG_01435 Haemophilus influenzae PittGG dihydrodipicolinate reductase YP_001291752.1 241645 R 374931 CDS YP_001291753.1 148827000 5226843 complement(242699..243133) 1 NC_009567.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 243133 nusB 5226843 nusB Haemophilus influenzae PittGG transcription antitermination protein NusB YP_001291753.1 242699 R 374931 CDS YP_001291754.1 148827001 5226844 complement(243137..243610) 1 NC_009567.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 243610 ribH 5226844 ribH Haemophilus influenzae PittGG 6,7-dimethyl-8-ribityllumazine synthase YP_001291754.1 243137 R 374931 CDS YP_001291755.1 148827002 5226845 243836..245239 1 NC_009567.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 245239 asnC 5226845 asnC Haemophilus influenzae PittGG asparaginyl-tRNA synthetase YP_001291755.1 243836 D 374931 CDS YP_001291756.1 148827003 5226846 245315..246004 1 NC_009567.1 COG0288 Carbonic anhydrase; asparaginyl-tRNA synthetase 246004 asnC 5226846 asnC Haemophilus influenzae PittGG asparaginyl-tRNA synthetase YP_001291756.1 245315 D 374931 CDS YP_001291757.1 148827004 5226847 complement(246032..247975) 1 NC_009567.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 247975 5226847 CGSHiGG_01460 Haemophilus influenzae PittGG ABC transporter ATPase YP_001291757.1 246032 R 374931 CDS YP_001291758.1 148827005 5226848 complement(248069..249454) 1 NC_009567.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein 249454 5226848 CGSHiGG_01465 Haemophilus influenzae PittGG deoxyguanosinetriphosphate triphosphohydrolase-like protein YP_001291758.1 248069 R 374931 CDS YP_001291759.1 148827006 5226849 complement(249666..250241) 1 NC_009567.1 COG1346 Putative effector of murein hydrolase; deoxyguanosinetriphosphate triphosphohydrolase-like protein 250241 5226849 CGSHiGG_01470 Haemophilus influenzae PittGG deoxyguanosinetriphosphate triphosphohydrolase-like protein YP_001291759.1 249666 R 374931 CDS YP_001291760.1 148827007 5226850 complement(250260..250682) 1 NC_009567.1 COG1380 Putative effector of murein hydrolase LrgA; hypothetical protein 250682 5226850 CGSHiGG_01475 Haemophilus influenzae PittGG hypothetical protein YP_001291760.1 250260 R 374931 CDS YP_001291761.1 148827008 5226851 250818..251279 1 NC_009567.1 COG1525 Micrococcal nuclease (thermonuclease) homologs; nuclease 251279 5226851 CGSHiGG_01480 Haemophilus influenzae PittGG nuclease YP_001291761.1 250818 D 374931 CDS YP_001291762.1 148827009 5226852 251281..252480 1 NC_009567.1 COG0520 Selenocysteine lyase; putative selenocysteine lyase 252480 5226852 CGSHiGG_01485 Haemophilus influenzae PittGG putative selenocysteine lyase YP_001291762.1 251281 D 374931 CDS YP_001291763.1 148827010 5226853 252477..252857 1 NC_009567.1 COG2166 SufE protein probably involved in Fe-S center assembly; hypothetical protein 252857 5226853 CGSHiGG_01490 Haemophilus influenzae PittGG hypothetical protein YP_001291763.1 252477 D 374931 CDS YP_001291764.1 148827011 5226854 252848..253633 1 NC_009567.1 COG5595 Zn-ribbon-containing, possibly nucleic-acid-binding protein; hypothetical protein 253633 5226854 CGSHiGG_01495 Haemophilus influenzae PittGG hypothetical protein YP_001291764.1 252848 D 374931 CDS YP_001291765.1 148827012 5226855 253760..254599 1 NC_009567.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 254599 queF 5226855 queF Haemophilus influenzae PittGG 7-cyano-7-deazaguanine reductase YP_001291765.1 253760 D 374931 CDS YP_001291766.1 148827013 5226856 complement(254632..255756) 1 NC_009567.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 255756 tyrA 5226856 tyrA Haemophilus influenzae PittGG bifunctional chorismate mutase/prephenate dehydrogenase YP_001291766.1 254632 R 374931 CDS YP_001291767.1 148827014 5226857 complement(255845..256765) 1 NC_009567.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 256765 truB 5226857 truB Haemophilus influenzae PittGG tRNA pseudouridine synthase B YP_001291767.1 255845 R 374931 CDS YP_001291768.1 148827015 5226858 257317..258993 1 NC_009567.1 putative type I restriction enzyme HindVIIP M protein 258993 5226858 CGSHiGG_01525 Haemophilus influenzae PittGG putative type I restriction enzyme HindVIIP M protein YP_001291768.1 257317 D 374931 CDS YP_001291769.1 148827016 5226859 258986..260365 1 NC_009567.1 putative type I restriction enzyme HindVIIP specificity protein 260365 5226859 CGSHiGG_01530 Haemophilus influenzae PittGG putative type I restriction enzyme HindVIIP specificity protein YP_001291769.1 258986 D 374931 CDS YP_001291770.1 148827017 5226860 260367..260891 1 NC_009567.1 COG0732 Restriction endonuclease S subunits; hypothetical protein 260891 5226860 CGSHiGG_01535 Haemophilus influenzae PittGG hypothetical protein YP_001291770.1 260367 D 374931 CDS YP_001291771.1 148827018 5226861 260928..261173 1 NC_009567.1 hypothetical protein 261173 5226861 CGSHiGG_01540 Haemophilus influenzae PittGG hypothetical protein YP_001291771.1 260928 D 374931 CDS YP_001291772.1 148827019 5226862 261357..261683 1 NC_009567.1 COG1338 Flagellar biosynthesis pathway, component FliP; hypothetical protein 261683 5226862 CGSHiGG_01545 Haemophilus influenzae PittGG hypothetical protein YP_001291772.1 261357 D 374931 CDS YP_001291773.1 148827020 5226863 complement(265042..267576) 1 NC_009567.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 267576 infB 5226863 infB Haemophilus influenzae PittGG translation initiation factor IF-2 YP_001291773.1 265042 R 374931 CDS YP_001291774.1 148827021 5226864 complement(267588..269075) 1 NC_009567.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 269075 nusA 5226864 nusA Haemophilus influenzae PittGG transcription elongation factor NusA YP_001291774.1 267588 R 374931 CDS YP_001291775.1 148827022 5226865 complement(269092..269547) 1 NC_009567.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 269547 5226865 CGSHiGG_01570 Haemophilus influenzae PittGG hypothetical protein YP_001291775.1 269092 R 374931 CDS YP_001291777.1 148827024 5226867 complement(270942..271058) 1 NC_009567.1 COG2801 Transposase and inactivated derivatives; transposase 271058 5226867 CGSHiGG_01580 Haemophilus influenzae PittGG transposase YP_001291777.1 270942 R 374931 CDS YP_001291778.1 148827025 5226868 complement(271536..272210) 1 NC_009567.1 COG1083 CMP-N-acetylneuraminic acid synthetase; acylneuraminate cytidylyltransferase 272210 5226868 CGSHiGG_01585 Haemophilus influenzae PittGG acylneuraminate cytidylyltransferase YP_001291778.1 271536 R 374931 CDS YP_001291779.1 148827026 5226869 272324..272971 1 NC_009567.1 COG0778 Nitroreductase; hypothetical protein 272971 5226869 CGSHiGG_01590 Haemophilus influenzae PittGG hypothetical protein YP_001291779.1 272324 D 374931 CDS YP_001291780.1 148827027 5226870 complement(273033..274145) 1 NC_009567.1 COG0489 ATPases involved in chromosome partitioning; putative ATPase 274145 5226870 CGSHiGG_01595 Haemophilus influenzae PittGG putative ATPase YP_001291780.1 273033 R 374931 CDS YP_001291781.1 148827028 5226871 274296..276344 1 NC_009567.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 276344 metG 5226871 metG Haemophilus influenzae PittGG methionyl-tRNA synthetase YP_001291781.1 274296 D 374931 CDS YP_001291782.1 148827029 5226872 complement(277368..278099) 1 NC_009567.1 COG0491 Zn-dependent hydrolases, including glyoxylases; hydroxyacylglutathione hydrolase 278099 5226872 CGSHiGG_01615 Haemophilus influenzae PittGG hydroxyacylglutathione hydrolase YP_001291782.1 277368 R 374931 CDS YP_001291783.1 148827030 5226873 complement(279719..279853) 1 NC_009567.1 COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components; hypothetical protein 279853 5226873 CGSHiGG_01645 Haemophilus influenzae PittGG hypothetical protein YP_001291783.1 279719 R 374931 CDS YP_001291784.1 148827031 5226874 complement(279825..280688) 1 NC_009567.1 COG0609 ABC-type Fe3+-siderophore transport system, permease component; ABC transporter permease 280688 5226874 CGSHiGG_01650 Haemophilus influenzae PittGG ABC transporter permease YP_001291784.1 279825 R 374931 CDS YP_001291785.1 148827032 5226875 complement(280734..281279) 1 NC_009567.1 periplasmic binding protein 281279 5226875 CGSHiGG_01655 Haemophilus influenzae PittGG periplasmic binding protein YP_001291785.1 280734 R 374931 CDS YP_001291786.1 148827033 5226876 281315..281635 1 NC_009567.1 COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component; hypothetical protein 281635 5226876 CGSHiGG_01660 Haemophilus influenzae PittGG hypothetical protein YP_001291786.1 281315 D 374931 CDS YP_001291787.1 148827034 5226877 complement(286802..287692) 1 NC_009567.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase 287692 metX 5226877 metX Haemophilus influenzae PittGG homoserine O-acetyltransferase YP_001291787.1 286802 R 374931 CDS YP_001291788.1 148827035 5226878 287993..288673 1 NC_009567.1 COG2949 Uncharacterized membrane protein; hypothetical protein 288673 5226878 CGSHiGG_01690 Haemophilus influenzae PittGG hypothetical protein YP_001291788.1 287993 D 374931 CDS YP_001291789.1 148827036 5226879 complement(290266..291156) 1 NC_009567.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 291156 5226879 CGSHiGG_01705 Haemophilus influenzae PittGG acetyl-CoA carboxylase subunit beta YP_001291789.1 290266 R 374931 CDS YP_001291790.1 148827037 5226880 complement(292794..296234) 1 NC_009567.1 transcription-repair coupling factor 296234 5226880 CGSHiGG_01720 Haemophilus influenzae PittGG transcription-repair coupling factor YP_001291790.1 292794 R 374931 CDS YP_001291791.1 148827038 5226881 complement(296337..296510) 1 NC_009567.1 COG1197 Transcription-repair coupling factor (superfamily II helicase); hypothetical protein 296510 5226881 CGSHiGG_01725 Haemophilus influenzae PittGG hypothetical protein YP_001291791.1 296337 R 374931 CDS YP_001291792.1 148827039 5226882 complement(296507..298351) 1 NC_009567.1 COG1444 Predicted P-loop ATPase fused to an acetyltransferase; P-loop ATPase fused to an acetyltransferase 298351 5226882 CGSHiGG_01730 Haemophilus influenzae PittGG P-loop ATPase fused to an acetyltransferase YP_001291792.1 296507 R 374931 CDS YP_001291793.1 148827040 5226883 complement(298356..298652) 1 NC_009567.1 COG3094 Uncharacterized protein conserved in bacteria; hypothetical protein 298652 5226883 CGSHiGG_01735 Haemophilus influenzae PittGG hypothetical protein YP_001291793.1 298356 R 374931 CDS YP_001291794.1 148827041 5226884 complement(298758..300428) 1 NC_009567.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein 300428 5226884 CGSHiGG_01740 Haemophilus influenzae PittGG putative ABC transporter ATP-binding protein YP_001291794.1 298758 R 374931 CDS YP_001291795.1 148827042 5226885 complement(300593..300916) 1 NC_009567.1 COG3093 Plasmid maintenance system antidote protein; plasmid maintenance system antidote protein 300916 5226885 CGSHiGG_01745 Haemophilus influenzae PittGG plasmid maintenance system antidote protein YP_001291795.1 300593 R 374931 CDS YP_001291796.1 148827043 5226886 complement(300927..301232) 1 NC_009567.1 COG3549 Plasmid maintenance system killer protein; plasmid maintenance system killer protein 301232 5226886 CGSHiGG_01750 Haemophilus influenzae PittGG plasmid maintenance system killer protein YP_001291796.1 300927 R 374931 CDS YP_001291797.1 148827044 5226887 303961..305799 1 NC_009567.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 305799 5226887 CGSHiGG_01775 Haemophilus influenzae PittGG excinuclease ABC subunit B YP_001291797.1 303961 D 374931 CDS YP_001291798.1 148827045 5226888 complement(305830..307773) 1 NC_009567.1 COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily; excinuclease ABC subunit B 307773 5226888 CGSHiGG_01780 Haemophilus influenzae PittGG excinuclease ABC subunit B YP_001291798.1 305830 R 374931 CDS YP_001291799.1 148827046 5226889 complement(307991..310261) 1 NC_009567.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 310261 5226889 CGSHiGG_01785 Haemophilus influenzae PittGG malic enzyme YP_001291799.1 307991 R 374931 CDS YP_001291800.1 148827047 5226890 310459..311079 1 NC_009567.1 COG3955 Exopolysaccharide biosynthesis protein; hypothetical protein 311079 5226890 CGSHiGG_01790 Haemophilus influenzae PittGG hypothetical protein YP_001291800.1 310459 D 374931 CDS YP_001291801.1 148827048 5226891 311170..311868 1 NC_009567.1 COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; malic enzyme 311868 5226891 CGSHiGG_01795 Haemophilus influenzae PittGG malic enzyme YP_001291801.1 311170 D 374931 CDS YP_001291802.1 148827049 5226892 311870..313066 1 NC_009567.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system 313066 5226892 CGSHiGG_01800 Haemophilus influenzae PittGG bicyclomycin/multidrug efflux system YP_001291802.1 311870 D 374931 CDS YP_001291803.1 148827050 5226893 complement(313098..313898) 1 NC_009567.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; hypothetical protein 313898 5226893 CGSHiGG_01805 Haemophilus influenzae PittGG hypothetical protein YP_001291803.1 313098 R 374931 CDS YP_001291804.1 148827051 5226894 313996..314658 1 NC_009567.1 COG2860 Predicted membrane protein; bicyclomycin/multidrug efflux system 314658 5226894 CGSHiGG_01810 Haemophilus influenzae PittGG bicyclomycin/multidrug efflux system YP_001291804.1 313996 D 374931 CDS YP_001291805.1 148827052 5226895 314679..315932 1 NC_009567.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 315932 proA 5226895 proA Haemophilus influenzae PittGG gamma-glutamyl phosphate reductase YP_001291805.1 314679 D 374931 CDS YP_001291806.1 148827053 5226896 complement(316011..317159) 1 NC_009567.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 317159 5226896 CGSHiGG_01820 Haemophilus influenzae PittGG chaperone protein DnaJ YP_001291806.1 316011 R 374931 CDS YP_001291807.1 148827054 5226897 complement(317386..319293) 1 NC_009567.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 319293 dnaK 5226897 dnaK Haemophilus influenzae PittGG molecular chaperone DnaK YP_001291807.1 317386 R 374931 CDS YP_001291808.1 148827055 5226898 319546..320988 1 NC_009567.1 COG5339 Uncharacterized protein conserved in bacteria; hypothetical protein 320988 proA 5226898 proA Haemophilus influenzae PittGG hypothetical protein YP_001291808.1 319546 D 374931 CDS YP_001291809.1 148827056 5226899 complement(321133..321591) 1 NC_009567.1 catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 321591 mgsA 5226899 mgsA Haemophilus influenzae PittGG methylglyoxal synthase YP_001291809.1 321133 R 374931 CDS YP_001291810.1 148827057 5226900 321890..324550 1 NC_009567.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 324550 aceE 5226900 aceE Haemophilus influenzae PittGG pyruvate dehydrogenase subunit E1 YP_001291810.1 321890 D 374931 CDS YP_001291811.1 148827058 5226901 324613..326274 1 NC_009567.1 COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes; dihydrolipoamide acetyltransferase 326274 5226901 CGSHiGG_01845 Haemophilus influenzae PittGG dihydrolipoamide acetyltransferase YP_001291811.1 324613 D 374931 CDS YP_001291812.1 148827059 5226902 326388..327812 1 NC_009567.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 327812 5226902 CGSHiGG_01850 Haemophilus influenzae PittGG dihydrolipoamide dehydrogenase YP_001291812.1 326388 D 374931 CDS YP_001291813.1 148827060 5226903 327970..328512 1 NC_009567.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 328512 5226903 CGSHiGG_01855 Haemophilus influenzae PittGG adenine phosphoribosyltransferase YP_001291813.1 327970 D 374931 CDS YP_001291814.1 148827061 5226904 328524..330590 1 NC_009567.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 330590 5226904 CGSHiGG_01860 Haemophilus influenzae PittGG DNA polymerase III subunits gamma and tau YP_001291814.1 328524 D 374931 CDS YP_001291815.1 148827062 5226905 330713..331339 1 NC_009567.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 331339 upp 5226905 upp Haemophilus influenzae PittGG uracil phosphoribosyltransferase YP_001291815.1 330713 D 374931 CDS YP_001291816.1 148827063 5226906 331443..332687 1 NC_009567.1 COG2233 Xanthine/uracil permeases; uracil phosphoribosyltransferase 332687 upp 5226906 upp Haemophilus influenzae PittGG uracil phosphoribosyltransferase YP_001291816.1 331443 D 374931 CDS YP_001291817.1 148827064 5226907 332888..333445 1 NC_009567.1 COG0593 ATPase involved in DNA replication initiation; DNA replication initiation factor 333445 5226907 CGSHiGG_01875 Haemophilus influenzae PittGG DNA replication initiation factor YP_001291817.1 332888 D 374931 CDS YP_001291818.1 148827065 5226908 complement(333474..333794) 1 NC_009567.1 involved in start site selection during the initiation of translation; translation initiation factor Sui1 333794 5226908 CGSHiGG_01880 Haemophilus influenzae PittGG translation initiation factor Sui1 YP_001291818.1 333474 R 374931 CDS YP_001291819.1 148827066 5226909 complement(333801..334475) 1 NC_009567.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 334475 5226909 CGSHiGG_01885 Haemophilus influenzae PittGG orotidine 5'-phosphate decarboxylase YP_001291819.1 333801 R 374931 CDS YP_001291820.1 148827067 5226910 complement(334518..335708) 1 NC_009567.1 COG2956 Predicted N-acetylglucosaminyl transferase; tetratricopeptide repeat protein 335708 5226910 CGSHiGG_01890 Haemophilus influenzae PittGG tetratricopeptide repeat protein YP_001291820.1 334518 R 374931 CDS YP_001291821.1 148827068 5226911 complement(335708..336001) 1 NC_009567.1 COG3771 Predicted membrane protein; hypothetical protein 336001 5226911 CGSHiGG_01895 Haemophilus influenzae PittGG hypothetical protein YP_001291821.1 335708 R 374931 CDS YP_001291822.1 148827069 5226912 complement(336076..336360) 1 NC_009567.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 336360 ihfB 5226912 ihfB Haemophilus influenzae PittGG integration host factor subunit beta YP_001291822.1 336076 R 374931 CDS YP_001291823.1 148827070 5226913 complement(336483..338132) 1 NC_009567.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 338132 rpsA 5226913 rpsA Haemophilus influenzae PittGG 30S ribosomal protein S1 YP_001291823.1 336483 R 374931 CDS YP_001291824.1 148827071 5226914 complement(338229..338906) 1 NC_009567.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 338906 cmk 5226914 cmk Haemophilus influenzae PittGG cytidylate kinase YP_001291824.1 338229 R 374931 CDS YP_001291825.1 148827072 5226915 339375..340250 1 NC_009567.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 340250 5226915 CGSHiGG_01915 Haemophilus influenzae PittGG pyridoxal biosynthesis lyase PdxS YP_001291825.1 339375 D 374931 CDS YP_001291826.1 148827073 5226916 340251..340829 1 NC_009567.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 340829 5226916 CGSHiGG_01920 Haemophilus influenzae PittGG glutamine amidotransferase subunit PdxT YP_001291826.1 340251 D 374931 CDS YP_001291827.1 148827074 5226917 complement(341378..343072) 1 NC_009567.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 343072 5226917 CGSHiGG_01925 Haemophilus influenzae PittGG D-lactate dehydrogenase YP_001291827.1 341378 R 374931 CDS YP_001291828.1 148827075 5226918 343331..343441 1 NC_009567.1 COG0277 FAD/FMN-containing dehydrogenases; hypothetical protein 343441 5226918 CGSHiGG_01930 Haemophilus influenzae PittGG hypothetical protein YP_001291828.1 343331 D 374931 CDS YP_001291829.1 148827076 5226919 complement(344644..346092) 1 NC_009567.1 COG0312 Predicted Zn-dependent proteases and their inactivated homologs; hypothetical protein 346092 5226919 CGSHiGG_01945 Haemophilus influenzae PittGG hypothetical protein YP_001291829.1 344644 R 374931 CDS YP_001291830.1 148827077 5226920 complement(346194..347045) 1 NC_009567.1 COG0313 Predicted methyltransferases; methyltransferase 347045 5226920 CGSHiGG_01950 Haemophilus influenzae PittGG methyltransferase YP_001291830.1 346194 R 374931 CDS YP_001291831.1 148827078 5226921 347117..348844 1 NC_009567.1 COG3107 Putative lipoprotein; D-lactate dehydrogenase 348844 5226921 CGSHiGG_01955 Haemophilus influenzae PittGG D-lactate dehydrogenase YP_001291831.1 347117 D 374931 CDS YP_001291832.1 148827079 5226922 348844..349203 1 NC_009567.1 COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase; hypothetical protein 349203 5226922 CGSHiGG_01960 Haemophilus influenzae PittGG hypothetical protein YP_001291832.1 348844 D 374931 CDS YP_001291833.1 148827080 5226923 349216..349800 1 NC_009567.1 COG0279 Phosphoheptose isomerase; hypothetical protein 349800 5226923 CGSHiGG_01965 Haemophilus influenzae PittGG hypothetical protein YP_001291833.1 349216 D 374931 CDS YP_001291834.1 148827081 5226924 349857..350438 1 NC_009567.1 COG2823 Predicted periplasmic or secreted lipoprotein; hypothetical protein 350438 5226924 CGSHiGG_01970 Haemophilus influenzae PittGG hypothetical protein YP_001291834.1 349857 D 374931 CDS YP_001291835.1 148827082 5226925 complement(354277..355506) 1 NC_009567.1 COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes; ribonucleotide-diphosphate reductase subunit beta 355506 nrdB 5226925 nrdB Haemophilus influenzae PittGG ribonucleotide-diphosphate reductase subunit beta YP_001291835.1 354277 R 374931 CDS YP_001291836.1 148827083 5226926 complement(355628..358435) 1 NC_009567.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 358435 sucA 5226926 sucA Haemophilus influenzae PittGG 2-oxoglutarate dehydrogenase E1 component YP_001291836.1 355628 R 374931 CDS YP_001291837.1 148827084 5226927 complement(358658..359158) 1 NC_009567.1 COG0790 FOG: TPR repeat, SEL1 subfamily; hypothetical protein 359158 5226927 CGSHiGG_02005 Haemophilus influenzae PittGG hypothetical protein YP_001291837.1 358658 R 374931 CDS YP_001291838.1 148827085 5226928 complement(359180..359923) 1 NC_009567.1 hypothetical protein 359923 5226928 CGSHiGG_02010 Haemophilus influenzae PittGG hypothetical protein YP_001291838.1 359180 R 374931 CDS YP_001291839.1 148827086 5226929 complement(359936..360289) 1 NC_009567.1 hypothetical protein 360289 5226929 CGSHiGG_02015 Haemophilus influenzae PittGG hypothetical protein YP_001291839.1 359936 R 374931 CDS YP_001291840.1 148827087 5226930 complement(360371..361213) 1 NC_009567.1 hypothetical protein 361213 5226930 CGSHiGG_02020 Haemophilus influenzae PittGG hypothetical protein YP_001291840.1 360371 R 374931 CDS YP_001291841.1 148827088 5226931 complement(361227..361499) 1 NC_009567.1 hypothetical protein 361499 5226931 CGSHiGG_02025 Haemophilus influenzae PittGG hypothetical protein YP_001291841.1 361227 R 374931 CDS YP_001291842.1 148827089 5226932 complement(361645..361716) 1 NC_009567.1 hypothetical protein 361716 5226932 CGSHiGG_02030 Haemophilus influenzae PittGG hypothetical protein YP_001291842.1 361645 R 374931 CDS YP_001291843.1 148827090 5226933 complement(361774..362037) 1 NC_009567.1 COG0790 FOG: TPR repeat, SEL1 subfamily; hypothetical protein 362037 5226933 CGSHiGG_02035 Haemophilus influenzae PittGG hypothetical protein YP_001291843.1 361774 R 374931 CDS YP_001291844.1 148827091 5226934 complement(362124..362762) 1 NC_009567.1 hypothetical protein 362762 5226934 CGSHiGG_02040 Haemophilus influenzae PittGG hypothetical protein YP_001291844.1 362124 R 374931 CDS YP_001291845.1 148827092 5226935 complement(363578..364138) 1 NC_009567.1 COG3108 Uncharacterized protein conserved in bacteria; hypothetical protein 364138 5226935 CGSHiGG_02055 Haemophilus influenzae PittGG hypothetical protein YP_001291845.1 363578 R 374931 CDS YP_001291846.1 148827093 5226936 complement(364154..365623) 1 NC_009567.1 COG2989 Uncharacterized protein conserved in bacteria; hypothetical protein 365623 kgd 5226936 kgd Haemophilus influenzae PittGG hypothetical protein YP_001291846.1 364154 R 374931 CDS YP_001291847.1 148827094 5226937 complement(365690..367777) 1 NC_009567.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 367777 5226937 CGSHiGG_02065 Haemophilus influenzae PittGG carboxy-terminal protease YP_001291847.1 365690 R 374931 CDS YP_001291848.1 148827095 5226938 complement(367805..368443) 1 NC_009567.1 affects solute and DNA transport through an unknown mechanism; putative solute/DNA competence effector 368443 5226938 CGSHiGG_02070 Haemophilus influenzae PittGG putative solute/DNA competence effector YP_001291848.1 367805 R 374931 CDS YP_001291849.1 148827096 5226939 complement(368563..368694) 1 NC_009567.1 COG3109 Activator of osmoprotectant transporter ProP; hypothetical protein 368694 5226939 CGSHiGG_02075 Haemophilus influenzae PittGG hypothetical protein YP_001291849.1 368563 R 374931 CDS YP_001291850.1 148827097 5226940 complement(372569..373021) 1 NC_009567.1 COG0314 Molybdopterin converting factor, large subunit; molybdopterin converting factor subunit 2 373021 5226940 CGSHiGG_02100 Haemophilus influenzae PittGG molybdopterin converting factor subunit 2 YP_001291850.1 372569 R 374931 CDS YP_001291851.1 148827098 5226941 complement(373022..373267) 1 NC_009567.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 373267 moaD 5226941 moaD Haemophilus influenzae PittGG molybdopterin synthase small subunit YP_001291851.1 373022 R 374931 CDS YP_001291852.1 148827099 5226942 complement(373269..373751) 1 NC_009567.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 373751 moaC 5226942 moaC Haemophilus influenzae PittGG molybdenum cofactor biosynthesis protein MoaC YP_001291852.1 373269 R 374931 CDS YP_001291853.1 148827100 5226943 complement(373843..374856) 1 NC_009567.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 374856 moaA 5226943 moaA Haemophilus influenzae PittGG molybdenum cofactor biosynthesis protein A YP_001291853.1 373843 R 374931 CDS YP_001291854.1 148827101 5226944 375301..375972 1 NC_009567.1 Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein 375972 5226944 CGSHiGG_02120 Haemophilus influenzae PittGG iron-sulfur cluster repair di-iron protein YP_001291854.1 375301 D 374931 CDS YP_001291855.1 148827102 5226945 376587..377522 1 NC_009567.1 COG0794 Predicted sugar phosphate isomerase involved in capsule formation; arabinose-5-phosphate isomerase 377522 5226945 CGSHiGG_02125 Haemophilus influenzae PittGG arabinose-5-phosphate isomerase YP_001291855.1 376587 D 374931 CDS YP_001291856.1 148827103 5226946 377532..378074 1 NC_009567.1 COG1778 Low specificity phosphatase (HAD superfamily); phosphatase 378074 5226946 CGSHiGG_02130 Haemophilus influenzae PittGG phosphatase YP_001291856.1 377532 D 374931 CDS YP_001291857.1 148827104 5226947 complement(378172..380328) 1 NC_009567.1 COG1289 Predicted membrane protein; molybdenum cofactor biosynthesis protein A 380328 moaA 5226947 moaA Haemophilus influenzae PittGG molybdenum cofactor biosynthesis protein A YP_001291857.1 378172 R 374931 CDS YP_001291858.1 148827105 5226948 complement(380396..381061) 1 NC_009567.1 COG3110 Uncharacterized protein conserved in bacteria; hypothetical protein 381061 5226948 CGSHiGG_02140 Haemophilus influenzae PittGG hypothetical protein YP_001291858.1 380396 R 374931 CDS YP_001291859.1 148827106 5226949 382604..383182 1 NC_009567.1 COG4657 Predicted NADH:ubiquinone oxidoreductase, subunit RnfA; Na(+)-translocating NADH-quinone reductase subunit E 383182 5226949 CGSHiGG_02155 Haemophilus influenzae PittGG Na(+)-translocating NADH-quinone reductase subunit E YP_001291859.1 382604 D 374931 CDS YP_001291860.1 148827107 5226950 383270..383926 1 NC_009567.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 383926 5226950 CGSHiGG_02160 Haemophilus influenzae PittGG electron transport complex protein RnfB YP_001291860.1 383270 D 374931 CDS YP_001291861.1 148827108 5226951 383923..385974 1 NC_009567.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 385974 5226951 CGSHiGG_02165 Haemophilus influenzae PittGG electron transport complex protein RnfC YP_001291861.1 383923 D 374931 CDS YP_001291862.1 148827109 5226952 385979..387055 1 NC_009567.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 387055 rnfD 5226952 rnfD Haemophilus influenzae PittGG electron transport complex protein RnfD YP_001291862.1 385979 D 374931 CDS YP_001291863.1 148827110 5226953 387055..387597 1 NC_009567.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 387597 5226953 CGSHiGG_02175 Haemophilus influenzae PittGG electron transport complex protein RnfG YP_001291863.1 387055 D 374931 CDS YP_001291864.1 148827111 5226954 387679..388383 1 NC_009567.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex RsxE subunit 388383 5226954 CGSHiGG_02180 Haemophilus influenzae PittGG electron transport complex RsxE subunit YP_001291864.1 387679 D 374931 CDS YP_001291865.1 148827112 5226955 388504..389139 1 NC_009567.1 COG0177 Predicted EndoIII-related endonuclease; endonuclease III 389139 5226955 CGSHiGG_02185 Haemophilus influenzae PittGG endonuclease III YP_001291865.1 388504 D 374931 CDS YP_001291866.1 148827113 5226956 389198..390571 1 NC_009567.1 COG0733 Na+-dependent transporters of the SNF family; SoxR-reducing system protein RsxE 390571 5226956 CGSHiGG_02190 Haemophilus influenzae PittGG SoxR-reducing system protein RsxE YP_001291866.1 389198 D 374931 CDS YP_001291867.1 148827114 5226957 complement(390595..391650) 1 NC_009567.1 Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 391650 modC 5226957 modC Haemophilus influenzae PittGG molybdate transporter ATP-binding protein YP_001291867.1 390595 R 374931 CDS YP_001291868.1 148827115 5226958 complement(391637..392365) 1 NC_009567.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease protein 392365 modB 5226958 modB Haemophilus influenzae PittGG molybdate ABC transporter permease protein YP_001291868.1 391637 R 374931 CDS YP_001291869.1 148827116 5226959 complement(392500..393264) 1 NC_009567.1 COG0725 ABC-type molybdate transport system, periplasmic component; molybdate-binding periplasmic protein 393264 5226959 CGSHiGG_02205 Haemophilus influenzae PittGG molybdate-binding periplasmic protein YP_001291869.1 392500 R 374931 CDS YP_001291870.1 148827117 5226960 393402..394169 1 NC_009567.1 COG2005 N-terminal domain of molybdenum-binding protein; molybdenum transport protein 394169 5226960 CGSHiGG_02210 Haemophilus influenzae PittGG molybdenum transport protein YP_001291870.1 393402 D 374931 CDS YP_001291871.1 148827118 5226961 complement(394279..395082) 1 NC_009567.1 COG0463 Glycosyltransferases involved in cell wall biogenesis; putative UDP-galactose--lipooligosaccharide galactosyltransferase 395082 5226961 CGSHiGG_02215 Haemophilus influenzae PittGG putative UDP-galactose--lipooligosaccharide galactosyltransferase YP_001291871.1 394279 R 374931 CDS YP_001291872.1 148827119 5226962 complement(396175..396750) 1 NC_009567.1 COG3306 Glycosyltransferase involved in LPS biosynthesis; putative UDP-GlcNAc--lipooligosaccharide N-acetylglucosaminyl glycosyltransferase 396750 5226962 CGSHiGG_02230 Haemophilus influenzae PittGG putative UDP-GlcNAc--lipooligosaccharide N-acetylglucosaminyl glycosyltransferase YP_001291872.1 396175 R 374931 CDS YP_001291873.1 148827120 5226963 complement(396762..397652) 1 NC_009567.1 lipopolysaccharide biosynthesis protein 397652 5226963 CGSHiGG_02235 Haemophilus influenzae PittGG lipopolysaccharide biosynthesis protein YP_001291873.1 396762 R 374931 CDS YP_001291874.1 148827121 5226964 complement(397649..397822) 1 NC_009567.1 COG0438 Glycosyltransferase; hypothetical protein 397822 5226964 CGSHiGG_02240 Haemophilus influenzae PittGG hypothetical protein YP_001291874.1 397649 R 374931 CDS YP_001291875.1 148827122 5226965 complement(397824..398738) 1 NC_009567.1 COG1112 Superfamily I DNA and RNA helicases and helicase subunits; lipopolysaccharide biosynthesis protein 398738 5226965 CGSHiGG_02245 Haemophilus influenzae PittGG lipopolysaccharide biosynthesis protein YP_001291875.1 397824 R 374931 CDS YP_001291876.1 148827123 5226966 complement(398735..399940) 1 NC_009567.1 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; lipopolysaccharide biosynthesis protein 399940 5226966 CGSHiGG_02250 Haemophilus influenzae PittGG lipopolysaccharide biosynthesis protein YP_001291876.1 398735 R 374931 CDS YP_001291877.1 148827124 5226967 400074..400817 1 NC_009567.1 COG1434 Uncharacterized conserved protein; hypothetical protein 400817 modB 5226967 modB Haemophilus influenzae PittGG hypothetical protein YP_001291877.1 400074 D 374931 CDS YP_001291878.1 148827125 5226968 complement(401039..403309) 1 NC_009567.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 403309 5226968 CGSHiGG_02260 Haemophilus influenzae PittGG 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase YP_001291878.1 401039 R 374931 CDS YP_001291879.1 148827126 5226969 complement(403503..404579) 1 NC_009567.1 COG0795 Predicted permeases; permease 404579 5226969 CGSHiGG_02265 Haemophilus influenzae PittGG permease YP_001291879.1 403503 R 374931 CDS YP_001291880.1 148827127 5226970 complement(404576..405679) 1 NC_009567.1 COG0795 Predicted permeases; 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 405679 5226970 CGSHiGG_02270 Haemophilus influenzae PittGG 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase YP_001291880.1 404576 R 374931 CDS YP_001291881.1 148827128 5226971 405786..407261 1 NC_009567.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 407261 5226971 CGSHiGG_02275 Haemophilus influenzae PittGG leucyl aminopeptidase YP_001291881.1 405786 D 374931 CDS YP_001291882.1 148827129 5226972 complement(407297..409324) 1 NC_009567.1 COG1292 Choline-glycine betaine transporter; choline-glycine betaine transporter 409324 5226972 CGSHiGG_02280 Haemophilus influenzae PittGG choline-glycine betaine transporter YP_001291882.1 407297 R 374931 CDS YP_001291883.1 148827130 5226973 complement(409601..410956) 1 NC_009567.1 COG0642 Signal transduction histidine kinase; sensor protein QseC 410956 5226973 CGSHiGG_02285 Haemophilus influenzae PittGG sensor protein QseC YP_001291883.1 409601 R 374931 CDS YP_001291884.1 148827131 5226974 complement(410953..411618) 1 NC_009567.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; transcriptional regulatory protein 411618 5226974 CGSHiGG_02290 Haemophilus influenzae PittGG transcriptional regulatory protein YP_001291884.1 410953 R 374931 CDS YP_001291885.1 148827132 5226975 complement(411681..412046) 1 NC_009567.1 hypothetical protein 412046 5226975 CGSHiGG_02295 Haemophilus influenzae PittGG hypothetical protein YP_001291885.1 411681 R 374931 CDS YP_001291886.1 148827133 5226976 complement(412161..412256) 1 NC_009567.1 COG3111 Uncharacterized conserved protein; leucyl aminopeptidase 412256 5226976 CGSHiGG_02300 Haemophilus influenzae PittGG leucyl aminopeptidase YP_001291886.1 412161 R 374931 CDS YP_001291887.1 148827134 5226977 complement(412393..412893) 1 NC_009567.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter subunit 412893 5226977 CGSHiGG_02305 Haemophilus influenzae PittGG PTS system glucose-specific transporter subunit YP_001291887.1 412393 R 374931 CDS YP_001291888.1 148827135 5226978 complement(412953..414680) 1 NC_009567.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 414680 5226978 CGSHiGG_02310 Haemophilus influenzae PittGG phosphoenolpyruvate-protein phosphotransferase YP_001291888.1 412953 R 374931 CDS YP_001291889.1 148827136 5226979 complement(414760..415017) 1 NC_009567.1 COG1925 Phosphotransferase system, HPr-related proteins; phosphoenolpyruvate-protein phosphotransferase 415017 5226979 CGSHiGG_02315 Haemophilus influenzae PittGG phosphoenolpyruvate-protein phosphotransferase YP_001291889.1 414760 R 374931 CDS YP_001291890.1 148827137 5226980 complement(415175..416215) 1 NC_009567.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 416215 5226980 CGSHiGG_02320 Haemophilus influenzae PittGG ribosome-associated GTPase YP_001291890.1 415175 R 374931 CDS YP_001291891.1 148827138 5226981 416285..416833 1 NC_009567.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 416833 5226981 CGSHiGG_02325 Haemophilus influenzae PittGG oligoribonuclease YP_001291891.1 416285 D 374931 CDS YP_001291892.1 148827139 5226982 complement(417135..418202) 1 NC_009567.1 COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase; oligoribonuclease 418202 5226982 CGSHiGG_02330 Haemophilus influenzae PittGG oligoribonuclease YP_001291892.1 417135 R 374931 CDS YP_001291893.1 148827140 5226983 complement(420964..421770) 1 NC_009567.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 421770 5226983 CGSHiGG_02345 Haemophilus influenzae PittGG methionine aminopeptidase YP_001291893.1 420964 R 374931 CDS YP_001291894.1 148827141 5226984 421906..422250 1 NC_009567.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 422250 5226984 CGSHiGG_02350 Haemophilus influenzae PittGG iron-sulfur cluster insertion protein ErpA YP_001291894.1 421906 D 374931 CDS YP_001291895.1 148827142 5226985 422303..422605 1 NC_009567.1 COG3112 Uncharacterized protein conserved in bacteria; hypothetical protein 422605 5226985 CGSHiGG_02355 Haemophilus influenzae PittGG hypothetical protein YP_001291895.1 422303 D 374931 CDS YP_001291896.1 148827143 5226988 425130..426002 1 NC_009567.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 426002 5226988 CGSHiGG_02365 Haemophilus influenzae PittGG phosphoribosylaminoimidazole-succinocarboxamide synthase YP_001291896.1 425130 D 374931 CDS YP_001291897.1 148827144 5226989 426158..427492 1 NC_009567.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 427492 5226989 CGSHiGG_02370 Haemophilus influenzae PittGG argininosuccinate synthase YP_001291897.1 426158 D 374931 CDS YP_001291898.1 148827145 5226990 complement(427563..428756) 1 NC_009567.1 COG1914 Mn2+ and Fe2+ transporters of the NRAMP family; argininosuccinate synthase 428756 5226990 CGSHiGG_02375 Haemophilus influenzae PittGG argininosuccinate synthase YP_001291898.1 427563 R 374931 CDS YP_001291899.1 148827146 5226991 complement(428800..429537) 1 NC_009567.1 COG1540 Uncharacterized proteins, homologs of lactam utilization protein B; LamB/YcsF family protein 429537 5226991 CGSHiGG_02380 Haemophilus influenzae PittGG LamB/YcsF family protein YP_001291899.1 428800 R 374931 CDS YP_001291900.1 148827147 5226992 complement(430449..431090) 1 NC_009567.1 COG2049 Allophanate hydrolase subunit 1; hypothetical protein 431090 5226992 CGSHiGG_02395 Haemophilus influenzae PittGG hypothetical protein YP_001291900.1 430449 R 374931 CDS YP_001291901.1 148827148 5226993 complement(431323..431931) 1 NC_009567.1 COG5295 Autotransporter adhesin; hypothetical protein 431931 5226993 CGSHiGG_02400 Haemophilus influenzae PittGG hypothetical protein YP_001291901.1 431323 R 374931 CDS YP_001291902.1 148827149 5226994 complement(431909..433888) 1 NC_009567.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II 433888 5226994 CGSHiGG_02405 Haemophilus influenzae PittGG exoribonuclease II YP_001291902.1 431909 R 374931 CDS YP_001291903.1 148827150 5226995 complement(434056..434760) 1 NC_009567.1 COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH); exoribonuclease II 434760 5226995 CGSHiGG_02410 Haemophilus influenzae PittGG exoribonuclease II YP_001291903.1 434056 R 374931 CDS YP_001291904.1 148827151 5226996 434939..436522 1 NC_009567.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 436522 prfC 5226996 prfC Haemophilus influenzae PittGG peptide chain release factor 3 YP_001291904.1 434939 D 374931 CDS YP_001291905.1 148827152 5226997 complement(436935..437264) 1 NC_009567.1 COG1687 Predicted branched-chain amino acid permeases (azaleucine resistance); putative branched-chain amino acid permease 437264 5226997 CGSHiGG_02420 Haemophilus influenzae PittGG putative branched-chain amino acid permease YP_001291905.1 436935 R 374931 CDS YP_001291906.1 148827153 5226998 complement(437261..437995) 1 NC_009567.1 COG1296 Predicted branched-chain amino acid permease (azaleucine resistance); putative branched-chain amino acid permease 437995 5226998 CGSHiGG_02425 Haemophilus influenzae PittGG putative branched-chain amino acid permease YP_001291906.1 437261 R 374931 CDS YP_001291907.1 148827154 5226999 complement(438005..438934) 1 NC_009567.1 COG0583 Transcriptional regulator; peptide chain release factor 3 438934 prfC 5226999 prfC Haemophilus influenzae PittGG peptide chain release factor 3 YP_001291907.1 438005 R 374931 CDS YP_001291908.1 148827155 5227002 complement(444978..446123) 1 NC_009567.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 446123 lldD 5227002 lldD Haemophilus influenzae PittGG L-lactate dehydrogenase YP_001291908.1 444978 R 374931 CDS YP_001291909.1 148827156 5227003 complement(446335..447144) 1 NC_009567.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 447144 5227003 CGSHiGG_02440 Haemophilus influenzae PittGG glutamate racemase YP_001291909.1 446335 R 374931 CDS YP_001291910.1 148827157 5227004 complement(447174..449255) 1 NC_009567.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 449255 5227004 CGSHiGG_02445 Haemophilus influenzae PittGG ATP-dependent DNA helicase RecG YP_001291910.1 447174 R 374931 CDS YP_001291911.1 148827158 5227005 complement(449252..451366) 1 NC_009567.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; glutamate racemase 451366 5227005 CGSHiGG_02450 Haemophilus influenzae PittGG glutamate racemase YP_001291911.1 449252 R 374931 CDS YP_001291912.1 148827159 5227006 complement(451439..451705) 1 NC_009567.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 451705 rpoZ 5227006 rpoZ Haemophilus influenzae PittGG DNA-directed RNA polymerase subunit omega YP_001291912.1 451439 R 374931 CDS YP_001291913.1 148827160 5227007 complement(451767..452393) 1 NC_009567.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 452393 gmk 5227007 gmk Haemophilus influenzae PittGG guanylate kinase YP_001291913.1 451767 R 374931 CDS YP_001291914.1 148827161 5227008 452644..453663 1 NC_009567.1 COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase 453663 5227008 CGSHiGG_02465 Haemophilus influenzae PittGG glyceraldehyde-3-phosphate dehydrogenase YP_001291914.1 452644 D 374931 CDS YP_001291915.1 148827162 5227009 453858..455657 1 NC_009567.1 COG1022 Long-chain acyl-CoA synthetases (AMP-forming); long chain fatty acid CoA ligase 455657 5227009 CGSHiGG_02470 Haemophilus influenzae PittGG long chain fatty acid CoA ligase YP_001291915.1 453858 D 374931 CDS YP_001291916.1 148827163 5227010 complement(455694..456479) 1 NC_009567.1 COG0561 Predicted hydrolases of the HAD superfamily; guanylate kinase 456479 gmk 5227010 gmk Haemophilus influenzae PittGG guanylate kinase YP_001291916.1 455694 R 374931 CDS YP_001291917.1 148827164 5227011 complement(456498..456962) 1 NC_009567.1 COG0319 Predicted metal-dependent hydrolase; putative metalloprotease 456962 5227011 CGSHiGG_02480 Haemophilus influenzae PittGG putative metalloprotease YP_001291917.1 456498 R 374931 CDS YP_001291918.1 148827165 5227012 complement(457220..458032) 1 NC_009567.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 458032 5227012 CGSHiGG_02485 Haemophilus influenzae PittGG formate dehydrogenase accessory protein YP_001291918.1 457220 R 374931 CDS YP_001291919.1 148827166 5227013 458303..458914 1 NC_009567.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; formate dehydrogenase major subunit 458914 5227013 CGSHiGG_02490 Haemophilus influenzae PittGG formate dehydrogenase major subunit YP_001291919.1 458303 D 374931 CDS YP_001291920.1 148827167 5227014 458963..461389 1 NC_009567.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; formate dehydrogenase major subunit 461389 5227014 CGSHiGG_02495 Haemophilus influenzae PittGG formate dehydrogenase major subunit YP_001291920.1 458963 D 374931 CDS YP_001291921.1 148827168 5227015 461391..463037 1 NC_009567.1 COG0437 Fe-S-cluster-containing hydrogenase components 1; formate dehydrogenase accessory protein 463037 5227015 CGSHiGG_02500 Haemophilus influenzae PittGG formate dehydrogenase accessory protein YP_001291921.1 461391 D 374931 CDS YP_001291922.1 148827169 5227016 463107..464015 1 NC_009567.1 required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 464015 5227016 CGSHiGG_02505 Haemophilus influenzae PittGG formate dehydrogenase accessory protein FdhE YP_001291922.1 463107 D 374931 CDS YP_001291923.1 148827170 5227017 complement(464054..464521) 1 NC_009567.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 464521 rimI 5227017 rimI Haemophilus influenzae PittGG ribosomal-protein-alanine N-acetyltransferase YP_001291923.1 464054 R 374931 CDS YP_001291924.1 148827171 5227018 complement(464497..464901) 1 NC_009567.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 464901 5227018 CGSHiGG_02515 Haemophilus influenzae PittGG DNA polymerase III subunit psi YP_001291924.1 464497 R 374931 CDS YP_001291925.1 148827172 5227019 465007..465999 1 NC_009567.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase 465999 rsmC 5227019 rsmC Haemophilus influenzae PittGG 16S ribosomal RNA m2G1207 methyltransferase YP_001291925.1 465007 D 374931 CDS YP_001291926.1 148827173 5227020 complement(466063..466785) 1 NC_009567.1 COG1159 GTPase; GTP-binding protein Era 466785 era 5227020 era Haemophilus influenzae PittGG GTP-binding protein Era YP_001291926.1 466063 R 374931 CDS YP_001291927.1 148827174 5227021 complement(466967..467650) 1 NC_009567.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 467650 rnc 5227021 rnc Haemophilus influenzae PittGG ribonuclease III YP_001291927.1 466967 R 374931 CDS YP_001291928.1 148827175 5227022 complement(468712..470508) 1 NC_009567.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 470508 5227022 CGSHiGG_02545 Haemophilus influenzae PittGG GTP-binding protein LepA YP_001291928.1 468712 R 374931 CDS YP_001291929.1 148827176 5227023 complement(470677..471060) 1 NC_009567.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA 471060 5227023 CGSHiGG_02550 Haemophilus influenzae PittGG autonomous glycyl radical cofactor GrcA YP_001291929.1 470677 R 374931 CDS YP_001291930.1 148827177 5227024 complement(472060..473484) 1 NC_009567.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 473484 5227024 CGSHiGG_02565 Haemophilus influenzae PittGG (dimethylallyl)adenosine tRNA methylthiotransferase YP_001291930.1 472060 R 374931 CDS YP_001291931.1 148827178 5227025 complement(473904..475343) 1 NC_009567.1 COG0471 Di- and tricarboxylate transporters; hypothetical protein 475343 5227025 CGSHiGG_02570 Haemophilus influenzae PittGG hypothetical protein YP_001291931.1 473904 R 374931 CDS YP_001291932.1 148827179 5227026 complement(475345..476568) 1 NC_009567.1 COG3697 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase); ATP:dephospho-CoA triphosphoribosyl transferase CitG 476568 5227026 CGSHiGG_02575 Haemophilus influenzae PittGG ATP:dephospho-CoA triphosphoribosyl transferase CitG YP_001291932.1 475345 R 374931 CDS YP_001291933.1 148827180 5227027 complement(476541..476741) 1 NC_009567.1 COG3697 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase); hypothetical protein 476741 5227027 CGSHiGG_02580 Haemophilus influenzae PittGG hypothetical protein YP_001291933.1 476541 R 374931 CDS YP_001291934.1 148827181 5227028 complement(478437..479312) 1 NC_009567.1 COG2301 Citrate lyase beta subunit; citrate lyase beta chain 479312 5227028 CGSHiGG_02600 Haemophilus influenzae PittGG citrate lyase beta chain YP_001291934.1 478437 R 374931 CDS YP_001291935.1 148827182 5227029 complement(479309..479596) 1 NC_009567.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma 479596 5227029 CGSHiGG_02605 Haemophilus influenzae PittGG citrate lyase subunit gamma YP_001291935.1 479309 R 374931 CDS YP_001291936.1 148827183 5227030 complement(479634..480641) 1 NC_009567.1 COG3053 Citrate lyase synthetase; uracil-DNA glycosylase 480641 5227030 CGSHiGG_02610 Haemophilus influenzae PittGG uracil-DNA glycosylase YP_001291936.1 479634 R 374931 CDS YP_001291937.1 148827184 5227031 complement(481018..481980) 1 NC_009567.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 481980 5227031 CGSHiGG_02615 Haemophilus influenzae PittGG lipoyl synthase YP_001291937.1 481018 R 374931 CDS YP_001291938.1 148827185 5227032 complement(482034..482672) 1 NC_009567.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 482672 lipB 5227032 lipB Haemophilus influenzae PittGG lipoate-protein ligase B YP_001291938.1 482034 R 374931 CDS YP_001291939.1 148827186 5227033 complement(482674..482952) 1 NC_009567.1 COG2921 Uncharacterized conserved protein; hypothetical protein 482952 5227033 CGSHiGG_02625 Haemophilus influenzae PittGG hypothetical protein YP_001291939.1 482674 R 374931 CDS YP_001291940.1 148827187 5227034 complement(485121..486236) 1 NC_009567.1 COG0772 Bacterial cell division membrane protein; rod shape-determining protein 486236 5227034 CGSHiGG_02650 Haemophilus influenzae PittGG rod shape-determining protein YP_001291940.1 485121 R 374931 CDS YP_001291941.1 148827188 5227035 complement(486226..488181) 1 NC_009567.1 COG0768 Cell division protein FtsI/penicillin-binding protein 2; penicillin-binding protein 2 488181 5227035 CGSHiGG_02655 Haemophilus influenzae PittGG penicillin-binding protein 2 YP_001291941.1 486226 R 374931 CDS YP_001291942.1 148827189 5227036 complement(488203..488670) 1 NC_009567.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 488670 5227036 CGSHiGG_02660 Haemophilus influenzae PittGG rRNA large subunit methyltransferase YP_001291942.1 488203 R 374931 CDS YP_001291943.1 148827190 5227037 complement(488724..489032) 1 NC_009567.1 COG0799 Uncharacterized homolog of plant Iojap protein; hypothetical protein 489032 5227037 CGSHiGG_02665 Haemophilus influenzae PittGG hypothetical protein YP_001291943.1 488724 R 374931 CDS YP_001291944.1 148827191 5227038 complement(489157..490812) 1 NC_009567.1 COG2985 Predicted permease; hypothetical protein 490812 5227038 CGSHiGG_02670 Haemophilus influenzae PittGG hypothetical protein YP_001291944.1 489157 R 374931 CDS YP_001291945.1 148827192 5227039 491018..492796 1 NC_009567.1 COG4178 ABC-type uncharacterized transport system, permease and ATPase components; ABC transporter ATP-binding protein 492796 5227039 CGSHiGG_02675 Haemophilus influenzae PittGG ABC transporter ATP-binding protein YP_001291945.1 491018 D 374931 CDS YP_001291946.1 148827193 5227040 492926..493981 1 NC_009567.1 functions in MreBCD complex in some organisms; rod shape-determining protein MreB 493981 5227040 CGSHiGG_02680 Haemophilus influenzae PittGG rod shape-determining protein MreB YP_001291946.1 492926 D 374931 CDS YP_001291947.1 148827194 5227041 494061..495116 1 NC_009567.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 495116 5227041 CGSHiGG_02685 Haemophilus influenzae PittGG rod shape-determining protein MreC YP_001291947.1 494061 D 374931 CDS YP_001291948.1 148827195 5227042 495116..495604 1 NC_009567.1 COG2891 Cell shape-determining protein; rod shape-determining protein MreD 495604 5227042 CGSHiGG_02690 Haemophilus influenzae PittGG rod shape-determining protein MreD YP_001291948.1 495116 D 374931 CDS YP_001291949.1 148827196 5227043 complement(495655..496431) 1 NC_009567.1 COG3076 Uncharacterized protein conserved in bacteria; hypothetical protein 496431 5227043 CGSHiGG_02695 Haemophilus influenzae PittGG hypothetical protein YP_001291949.1 495655 R 374931 CDS YP_001291950.1 148827197 5227044 complement(496441..497244) 1 NC_009567.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 497244 5227044 CGSHiGG_02700 Haemophilus influenzae PittGG exonuclease III YP_001291950.1 496441 R 374931 CDS YP_001291951.1 148827198 5227045 complement(497292..497966) 1 NC_009567.1 COG0564 Pseudouridylate synthases, 23S RNA-specific; exonuclease III 497966 5227045 CGSHiGG_02705 Haemophilus influenzae PittGG exonuclease III YP_001291951.1 497292 R 374931 CDS YP_001291952.1 148827199 5227046 complement(497966..499030) 1 NC_009567.1 COG3768 Predicted membrane protein; hypothetical protein 499030 5227046 CGSHiGG_02710 Haemophilus influenzae PittGG hypothetical protein YP_001291952.1 497966 R 374931 CDS YP_001291953.1 148827200 5227047 complement(499087..499749) 1 NC_009567.1 COG0670 Integral membrane protein, interacts with FtsH; FtsH-interacting integral membrane protein 499749 5227047 CGSHiGG_02715 Haemophilus influenzae PittGG FtsH-interacting integral membrane protein YP_001291953.1 499087 R 374931 CDS YP_001291954.1 148827201 5227048 complement(500076..500630) 1 NC_009567.1 COG3054 Predicted transcriptional regulator; hypothetical protein 500630 5227048 CGSHiGG_02720 Haemophilus influenzae PittGG hypothetical protein YP_001291954.1 500076 R 374931 CDS YP_001291955.1 148827202 5227049 500734..501060 1 NC_009567.1 COG2824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism; hypothetical protein 501060 5227049 CGSHiGG_02725 Haemophilus influenzae PittGG hypothetical protein YP_001291955.1 500734 D 374931 CDS YP_001291956.1 148827203 5227050 complement(501762..503165) 1 NC_009567.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase 503165 5227050 CGSHiGG_02740 Haemophilus influenzae PittGG glucuronate isomerase YP_001291956.1 501762 R 374931 CDS YP_001291957.1 148827204 5227051 complement(503234..504637) 1 NC_009567.1 COG2211 Na+/melibiose symporter and related transporters; glucuronide permease 504637 5227051 CGSHiGG_02745 Haemophilus influenzae PittGG glucuronide permease YP_001291957.1 503234 R 374931 CDS YP_001291958.1 148827205 5227052 complement(504656..506416) 1 NC_009567.1 COG1472 Beta-glucosidase-related glycosidases; beta-hexosamidase A 506416 5227052 CGSHiGG_02750 Haemophilus influenzae PittGG beta-hexosamidase A YP_001291958.1 504656 R 374931 CDS YP_001291959.1 148827206 5227053 complement(506427..507308) 1 NC_009567.1 COG0546 Predicted phosphatases; glucuronate isomerase 507308 5227053 CGSHiGG_02755 Haemophilus influenzae PittGG glucuronate isomerase YP_001291959.1 506427 R 374931 CDS YP_001291960.1 148827207 5227055 complement(507277..508122) 1 NC_009567.1 Converts D-mannonate to D-mannuronate; D-mannonate oxidoreductase 508122 5227055 CGSHiGG_02760 Haemophilus influenzae PittGG D-mannonate oxidoreductase YP_001291960.1 507277 R 374931 CDS YP_001291961.1 148827208 5227056 508477..508749 1 NC_009567.1 COG3676 Transposase and inactivated derivatives; putative transposase-like protein 508749 5227056 CGSHiGG_02765 Haemophilus influenzae PittGG putative transposase-like protein YP_001291961.1 508477 D 374931 CDS YP_001291962.1 148827209 5227057 508850..509605 1 NC_009567.1 COG2186 Transcriptional regulators; D-mannonate oxidoreductase 509605 5227057 CGSHiGG_02770 Haemophilus influenzae PittGG D-mannonate oxidoreductase YP_001291962.1 508850 D 374931 CDS YP_001291963.1 148827210 5227058 509625..510809 1 NC_009567.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 510809 5227058 CGSHiGG_02775 Haemophilus influenzae PittGG mannonate dehydratase YP_001291963.1 509625 D 374931 CDS YP_001291964.1 148827211 5227059 complement(510862..511575) 1 NC_009567.1 COG0861 Membrane protein TerC, possibly involved in tellurium resistance; mannonate dehydratase 511575 5227059 CGSHiGG_02780 Haemophilus influenzae PittGG mannonate dehydratase YP_001291964.1 510862 R 374931 CDS YP_001291965.1 148827212 5227060 complement(513645..514409) 1 NC_009567.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 514409 5227060 CGSHiGG_02800 Haemophilus influenzae PittGG 3-deoxy-manno-octulosonate cytidylyltransferase YP_001291965.1 513645 R 374931 CDS YP_001291966.1 148827213 5227061 complement(514480..515382) 1 NC_009567.1 COG1663 Tetraacyldisaccharide-1-P 4'-kinase; tetraacyldisaccharide 4'-kinase 515382 lpxK 5227061 lpxK Haemophilus influenzae PittGG tetraacyldisaccharide 4'-kinase YP_001291966.1 514480 R 374931 CDS YP_001291967.1 148827214 5227062 complement(515551..517314) 1 NC_009567.1 involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease protein 517314 5227062 CGSHiGG_02810 Haemophilus influenzae PittGG lipid transporter ATP-binding/permease protein YP_001291967.1 515551 R 374931 CDS YP_001291968.1 148827215 5227063 519981..520418 1 NC_009567.1 COG1734 DnaK suppressor protein; DnaK suppressor protein 520418 5227063 CGSHiGG_02825 Haemophilus influenzae PittGG DnaK suppressor protein YP_001291968.1 519981 D 374931 CDS YP_001291969.1 148827216 5227064 520666..522024 1 NC_009567.1 COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; polyA polymerase 522024 5227064 CGSHiGG_02830 Haemophilus influenzae PittGG polyA polymerase YP_001291969.1 520666 D 374931 CDS YP_001291970.1 148827217 5227065 522033..522515 1 NC_009567.1 COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 522515 5227065 CGSHiGG_02835 Haemophilus influenzae PittGG 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_001291970.1 522033 D 374931 CDS YP_001291971.1 148827218 5227066 522630..523067 1 NC_009567.1 COG0802 Predicted ATPase or kinase; hypothetical protein 523067 5227066 CGSHiGG_02840 Haemophilus influenzae PittGG hypothetical protein YP_001291971.1 522630 D 374931 CDS YP_001291972.1 148827219 5227067 523075..524373 1 NC_009567.1 COG0860 N-acetylmuramoyl-L-alanine amidase; lipid ABC transporter membrane protein/ATP-binding protein 524373 5227067 CGSHiGG_02845 Haemophilus influenzae PittGG lipid ABC transporter membrane protein/ATP-binding protein YP_001291972.1 523075 D 374931 CDS YP_001291973.1 148827220 5227068 524374..526263 1 NC_009567.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 526263 mutL 5227068 mutL Haemophilus influenzae PittGG DNA mismatch repair protein YP_001291973.1 524374 D 374931 CDS YP_001291974.1 148827221 5227069 527211..530156 1 NC_009567.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 530156 5227069 CGSHiGG_02865 Haemophilus influenzae PittGG bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase YP_001291974.1 527211 D 374931 CDS YP_001291975.1 148827222 5227070 complement(532031..532921) 1 NC_009567.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 532921 ppnK 5227070 ppnK Haemophilus influenzae PittGG inorganic polyphosphate/ATP-NAD kinase YP_001291975.1 532031 R 374931 CDS YP_001291976.1 148827223 5227071 532913..533617 1 NC_009567.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 533617 5227071 CGSHiGG_02890 Haemophilus influenzae PittGG heat shock protein GrpE YP_001291976.1 532913 D 374931 CDS YP_001291977.1 148827224 5227072 complement(533630..533974) 1 NC_009567.1 nucleotidyltransferase 533974 5227072 CGSHiGG_02895 Haemophilus influenzae PittGG nucleotidyltransferase YP_001291977.1 533630 R 374931 CDS YP_001291978.1 148827225 5227073 complement(533976..534404) 1 NC_009567.1 COG1708 Predicted nucleotidyltransferases; inorganic polyphosphate/ATP-NAD kinase 534404 ppnK 5227073 ppnK Haemophilus influenzae PittGG inorganic polyphosphate/ATP-NAD kinase YP_001291978.1 533976 R 374931 CDS YP_001291979.1 148827226 5227074 535224..535319 1 NC_009567.1 COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; hypothetical protein 535319 5227074 CGSHiGG_02910 Haemophilus influenzae PittGG hypothetical protein YP_001291979.1 535224 D 374931 CDS YP_001291980.1 148827227 5227075 536931..537791 1 NC_009567.1 anaerobic ribonucleoside triphosphate reductase 537791 5227075 CGSHiGG_02920 Haemophilus influenzae PittGG anaerobic ribonucleoside triphosphate reductase YP_001291980.1 536931 D 374931 CDS YP_001291981.1 148827228 5227076 537800..537874 1 NC_009567.1 COG1946 Acyl-CoA thioesterase; hypothetical protein 537874 5227076 CGSHiGG_02925 Haemophilus influenzae PittGG hypothetical protein YP_001291981.1 537800 D 374931 CDS YP_001291982.1 148827229 5227077 complement(537950..539329) 1 NC_009567.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 539329 cysS 5227077 cysS Haemophilus influenzae PittGG cysteinyl-tRNA synthetase YP_001291982.1 537950 R 374931 CDS YP_001291983.1 148827230 5227078 539432..539941 1 NC_009567.1 COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; peptidyl-prolyl cis-trans isomerase B 539941 5227078 CGSHiGG_02935 Haemophilus influenzae PittGG peptidyl-prolyl cis-trans isomerase B YP_001291983.1 539432 D 374931 CDS YP_001291984.1 148827231 5227079 540894..540992 1 NC_009567.1 COG0084 Mg-dependent DNase; hypothetical protein 540992 5227079 CGSHiGG_02950 Haemophilus influenzae PittGG hypothetical protein YP_001291984.1 540894 D 374931 CDS YP_001291985.1 148827232 5227080 541040..541306 1 NC_009567.1 hypothetical protein 541306 5227080 CGSHiGG_02955 Haemophilus influenzae PittGG hypothetical protein YP_001291985.1 541040 D 374931 CDS YP_001291986.1 148827233 5227081 541282..541590 1 NC_009567.1 COG1960 Acyl-CoA dehydrogenases; hypothetical protein 541590 5227081 CGSHiGG_02960 Haemophilus influenzae PittGG hypothetical protein YP_001291986.1 541282 D 374931 CDS YP_001291987.1 148827234 5227082 complement(541587..541910) 1 NC_009567.1 COG0526 Thiol-disulfide isomerase and thioredoxins; thioredoxin 541910 5227082 CGSHiGG_02965 Haemophilus influenzae PittGG thioredoxin YP_001291987.1 541587 R 374931 CDS YP_001291988.1 148827235 5227083 complement(542029..543024) 1 NC_009567.1 COG1052 Lactate dehydrogenase and related dehydrogenases; cysteinyl-tRNA synthetase 543024 cysS 5227083 cysS Haemophilus influenzae PittGG cysteinyl-tRNA synthetase YP_001291988.1 542029 R 374931 CDS YP_001291989.1 148827236 5227084 complement(545011..546288) 1 NC_009567.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 546288 5227084 CGSHiGG_02985 Haemophilus influenzae PittGG threonine synthase YP_001291989.1 545011 R 374931 CDS YP_001291990.1 148827237 5227085 complement(546331..547275) 1 NC_009567.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 547275 5227085 CGSHiGG_02990 Haemophilus influenzae PittGG homoserine kinase YP_001291990.1 546331 R 374931 CDS YP_001291991.1 148827238 5227086 complement(549829..549915) 1 NC_009567.1 COG0527 Aspartokinases; hypothetical protein 549915 5227086 CGSHiGG_03005 Haemophilus influenzae PittGG hypothetical protein YP_001291991.1 549829 R 374931 CDS YP_001291992.1 148827239 5227087 550060..550761 1 NC_009567.1 COG0325 Predicted enzyme with a TIM-barrel fold; hypothetical protein 550761 5227087 CGSHiGG_03010 Haemophilus influenzae PittGG hypothetical protein YP_001291992.1 550060 D 374931 CDS YP_001291993.1 148827240 5227088 complement(550834..551589) 1 NC_009567.1 hypothetical protein 551589 5227088 CGSHiGG_03015 Haemophilus influenzae PittGG hypothetical protein YP_001291993.1 550834 R 374931 CDS YP_001291994.1 148827241 5227095 552223..553221 1 NC_009567.1 COG1840 ABC-type Fe3+ transport system, periplasmic component; iron-utilization periplasmic protein FbpA 553221 5227095 CGSHiGG_03025 Haemophilus influenzae PittGG iron-utilization periplasmic protein FbpA YP_001291994.1 552223 D 374931 CDS YP_001291995.1 148827242 5227097 complement(555951..556631) 1 NC_009567.1 COG1876 D-alanyl-D-alanine carboxypeptidase; bifunctional aspartokinase I/homoserine dehydrogenase I 556631 thrA 5227097 thrA Haemophilus influenzae PittGG bifunctional aspartokinase I/homoserine dehydrogenase I YP_001291995.1 555951 R 374931 CDS YP_001291996.1 148827243 5227098 complement(556633..557766) 1 NC_009567.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 557766 5227098 CGSHiGG_03055 Haemophilus influenzae PittGG succinyl-diaminopimelate desuccinylase YP_001291996.1 556633 R 374931 CDS YP_001291997.1 148827244 5227099 complement(557794..558138) 1 NC_009567.1 COG1393 Arsenate reductase and related proteins, glutaredoxin family; succinyl-diaminopimelate desuccinylase 558138 5227099 CGSHiGG_03060 Haemophilus influenzae PittGG succinyl-diaminopimelate desuccinylase YP_001291997.1 557794 R 374931 CDS YP_001291998.1 148827245 5227100 complement(558217..560097) 1 NC_009567.1 molecular chaperone; heat shock protein 90 560097 5227100 CGSHiGG_03065 Haemophilus influenzae PittGG heat shock protein 90 YP_001291998.1 558217 R 374931 CDS YP_001291999.1 148827246 5227101 561338..563710 1 NC_009567.1 COG0286 Type I restriction-modification system methyltransferase subunit; putative type I restriction-modification system, methyltransferase subunit 563710 5227101 CGSHiGG_03080 Haemophilus influenzae PittGG putative type I restriction-modification system, methyltransferase subunit YP_001291999.1 561338 D 374931 CDS YP_001292000.1 148827247 5227102 563899..565173 1 NC_009567.1 COG0732 Restriction endonuclease S subunits; type I restriction modification DNA specificity domain-containing protein 565173 5227102 CGSHiGG_03085 Haemophilus influenzae PittGG type I restriction modification DNA specificity domain-containing protein YP_001292000.1 563899 D 374931 CDS YP_001292001.1 148827248 5227103 565268..568288 1 NC_009567.1 COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases; putative type I site-specific restriction-modification system, R subunit 568288 5227103 CGSHiGG_03090 Haemophilus influenzae PittGG putative type I site-specific restriction-modification system, R subunit YP_001292001.1 565268 D 374931 CDS YP_001292002.1 148827249 5227104 complement(568513..569901) 1 NC_009567.1 COG0541 Signal recognition particle GTPase; Signal recognition particle protein 569901 5227104 CGSHiGG_03095 Haemophilus influenzae PittGG Signal recognition particle protein YP_001292002.1 568513 R 374931 CDS YP_001292003.1 148827250 5227105 570182..571444 1 NC_009567.1 putative Mg2+ and Co2+ transporter 571444 5227105 CGSHiGG_03100 Haemophilus influenzae PittGG putative Mg2+ and Co2+ transporter YP_001292003.1 570182 D 374931 CDS YP_001292004.1 148827251 5227106 complement(571441..571515) 1 NC_009567.1 COG4536 Putative Mg2+ and Co2+ transporter CorB; hypothetical protein 571515 5227106 CGSHiGG_03105 Haemophilus influenzae PittGG hypothetical protein YP_001292004.1 571441 R 374931 CDS YP_001292005.1 148827252 5227107 571573..572343 1 NC_009567.1 COG2966 Uncharacterized conserved protein; hypothetical protein 572343 5227107 CGSHiGG_03110 Haemophilus influenzae PittGG hypothetical protein YP_001292005.1 571573 D 374931 CDS YP_001292006.1 148827253 5227108 572345..572824 1 NC_009567.1 hypothetical protein 572824 5227108 CGSHiGG_03115 Haemophilus influenzae PittGG hypothetical protein YP_001292006.1 572345 D 374931 CDS YP_001292007.1 148827254 5227109 complement(572997..573254) 1 NC_009567.1 COG3610 Uncharacterized conserved protein; heat shock protein 90 573254 5227109 CGSHiGG_03120 Haemophilus influenzae PittGG heat shock protein 90 YP_001292007.1 572997 R 374931 CDS YP_001292008.1 148827255 5227110 573421..574710 1 NC_009567.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 574710 5227110 CGSHiGG_03125 Haemophilus influenzae PittGG seryl-tRNA synthetase YP_001292008.1 573421 D 374931 CDS YP_001292009.1 148827256 5227111 575045..575674 1 NC_009567.1 COG0625 Glutathione S-transferase; glutathione S-transferase 575674 5227111 CGSHiGG_03130 Haemophilus influenzae PittGG glutathione S-transferase YP_001292009.1 575045 D 374931 CDS YP_001292010.1 148827257 5227112 complement(575686..575982) 1 NC_009567.1 COG2963 Transposase and inactivated derivatives; hypothetical protein 575982 5227112 CGSHiGG_03135 Haemophilus influenzae PittGG hypothetical protein YP_001292010.1 575686 R 374931 CDS YP_001292011.1 148827258 5227115 complement(585341..587476) 1 NC_009567.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 587476 rlmL 5227115 rlmL Haemophilus influenzae PittGG 23S rRNA m(2)G2445 methyltransferase YP_001292011.1 585341 R 374931 CDS YP_001292012.1 148827259 5227116 587871..588980 1 NC_009567.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A 588980 mltA 5227116 mltA Haemophilus influenzae PittGG murein transglycosylase A YP_001292012.1 587871 D 374931 CDS YP_001292013.1 148827260 5227117 588965..589750 1 NC_009567.1 COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1; murein transglycosylase A 589750 mltA 5227117 mltA Haemophilus influenzae PittGG murein transglycosylase A YP_001292013.1 588965 D 374931 CDS YP_001292014.1 148827261 5227118 589929..591032 1 NC_009567.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic component 591032 znuA 5227118 znuA Haemophilus influenzae PittGG high-affinity zinc transporter periplasmic component YP_001292014.1 589929 D 374931 CDS YP_001292015.1 148827262 5227119 complement(591082..591588) 1 NC_009567.1 COG5413 Uncharacterized integral membrane protein; hypothetical protein 591588 5227119 CGSHiGG_03180 Haemophilus influenzae PittGG hypothetical protein YP_001292015.1 591082 R 374931 CDS YP_001292016.1 148827263 5227120 complement(591701..593062) 1 NC_009567.1 high-affinity zinc transporter periplasmic component 593062 znuA 5227120 znuA Haemophilus influenzae PittGG high-affinity zinc transporter periplasmic component YP_001292016.1 591701 R 374931 CDS YP_001292017.1 148827264 5227121 593372..593491 1 NC_009567.1 COG0773 UDP-N-acetylmuramate-alanine ligase; hypothetical protein 593491 5227121 CGSHiGG_03190 Haemophilus influenzae PittGG hypothetical protein YP_001292017.1 593372 D 374931 CDS YP_001292018.1 148827265 5227122 complement(593540..594727) 1 NC_009567.1 catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 594727 5227122 CGSHiGG_03195 Haemophilus influenzae PittGG cystathionine beta-lyase YP_001292018.1 593540 R 374931 CDS YP_001292019.1 148827266 5227123 594864..595466 1 NC_009567.1 COG0450 Peroxiredoxin; peroxiredoxin 595466 5227123 CGSHiGG_03200 Haemophilus influenzae PittGG peroxiredoxin YP_001292019.1 594864 D 374931 CDS YP_001292020.1 148827267 5227124 595567..596112 1 NC_009567.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 596112 5227124 CGSHiGG_03205 Haemophilus influenzae PittGG CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase YP_001292020.1 595567 D 374931 CDS YP_001292022.1 148827269 5227126 complement(596694..597224) 1 NC_009567.1 COG0221 Inorganic pyrophosphatase; inorganic pyrophosphatase 597224 5227126 CGSHiGG_03215 Haemophilus influenzae PittGG inorganic pyrophosphatase YP_001292022.1 596694 R 374931 CDS YP_001292023.1 148827270 5227127 597458..598774 1 NC_009567.1 COG2252 Permeases; cystathionine beta-lyase 598774 5227127 CGSHiGG_03220 Haemophilus influenzae PittGG cystathionine beta-lyase YP_001292023.1 597458 D 374931 CDS YP_001292024.1 148827271 5227128 complement(598863..599912) 1 NC_009567.1 Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import; ferric transporter ATP-binding subunit 599912 fbpC 5227128 fbpC Haemophilus influenzae PittGG ferric transporter ATP-binding subunit YP_001292024.1 598863 R 374931 CDS YP_001292025.1 148827272 5227129 complement(599937..601994) 1 NC_009567.1 COG1178 ABC-type Fe3+ transport system, permease component; ferric transport system permease protein FbpB 601994 5227129 CGSHiGG_03230 Haemophilus influenzae PittGG ferric transport system permease protein FbpB YP_001292025.1 599937 R 374931 CDS YP_001292026.1 148827273 5227130 complement(602156..603196) 1 NC_009567.1 COG1840 ABC-type Fe3+ transport system, periplasmic component; ferric transporter ATP-binding subunit 603196 fbpC 5227130 fbpC Haemophilus influenzae PittGG ferric transporter ATP-binding subunit YP_001292026.1 602156 R 374931 CDS YP_001292027.1 148827274 5227131 603362..604003 1 NC_009567.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 604003 5227131 CGSHiGG_03240 Haemophilus influenzae PittGG uridine kinase YP_001292027.1 603362 D 374931 CDS YP_001292028.1 148827275 5227132 604012..604599 1 NC_009567.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 604599 dcd 5227132 dcd Haemophilus influenzae PittGG deoxycytidine triphosphate deaminase YP_001292028.1 604012 D 374931 CDS YP_001292029.1 148827276 5227136 605778..606968 1 NC_009567.1 COG2814 Arabinose efflux permease; sugar efflux transporter 606968 5227136 CGSHiGG_03255 Haemophilus influenzae PittGG sugar efflux transporter YP_001292029.1 605778 D 374931 CDS YP_001292030.1 148827277 5227137 complement(607047..608561) 1 NC_009567.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 608561 engA 5227137 engA Haemophilus influenzae PittGG GTP-binding protein EngA YP_001292030.1 607047 R 374931 CDS YP_001292031.1 148827278 5227138 complement(609241..610011) 1 NC_009567.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 610011 5227138 CGSHiGG_03265 Haemophilus influenzae PittGG DNA polymerase III subunit epsilon YP_001292031.1 609241 R 374931 CDS YP_001292032.1 148827279 5227139 610072..610536 1 NC_009567.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 610536 rnhA 5227139 rnhA Haemophilus influenzae PittGG ribonuclease H YP_001292032.1 610072 D 374931 CDS YP_001292033.1 148827280 5227140 610814..611953 1 NC_009567.1 COG3203 Outer membrane protein (porin); Outer membrane protein P2 611953 5227140 CGSHiGG_03275 Haemophilus influenzae PittGG Outer membrane protein P2 YP_001292033.1 610814 D 374931 CDS YP_001292034.1 148827281 5227141 complement(612187..613335) 1 NC_009567.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 613335 nagA 5227141 nagA Haemophilus influenzae PittGG N-acetylglucosamine-6-phosphate deacetylase YP_001292034.1 612187 R 374931 CDS YP_001292035.1 148827282 5227142 complement(614300..614455) 1 NC_009567.1 COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase; hypothetical protein 614455 5227142 CGSHiGG_03295 Haemophilus influenzae PittGG hypothetical protein YP_001292035.1 614300 R 374931 CDS YP_001292036.1 148827283 5227143 complement(614598..615479) 1 NC_009567.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 615479 5227143 CGSHiGG_03300 Haemophilus influenzae PittGG N-acetylneuraminate lyase YP_001292036.1 614598 R 374931 CDS YP_001292037.1 148827284 5227144 complement(615490..616356) 1 NC_009567.1 COG1737 Transcriptional regulators; hypothetical protein 616356 5227144 CGSHiGG_03305 Haemophilus influenzae PittGG hypothetical protein YP_001292037.1 615490 R 374931 CDS YP_001292038.1 148827285 5227145 complement(616349..617251) 1 NC_009567.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 617251 5227145 CGSHiGG_03310 Haemophilus influenzae PittGG N-acetylmannosamine kinase YP_001292038.1 616349 R 374931 CDS YP_001292039.1 148827286 5227146 complement(617296..617982) 1 NC_009567.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 617982 5227146 CGSHiGG_03315 Haemophilus influenzae PittGG N-acetylmannosamine-6-phosphate 2-epimerase YP_001292039.1 617296 R 374931 CDS YP_001292040.1 148827287 5227147 618333..619319 1 NC_009567.1 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component; hypothetical protein 619319 5227147 CGSHiGG_03320 Haemophilus influenzae PittGG hypothetical protein YP_001292040.1 618333 D 374931 CDS YP_001292041.1 148827288 5227148 619384..621234 1 NC_009567.1 COG3090 TRAP-type C4-dicarboxylate transport system, small permease component; hypothetical protein 621234 5227148 CGSHiGG_03325 Haemophilus influenzae PittGG hypothetical protein YP_001292041.1 619384 D 374931 CDS YP_001292042.1 148827289 5227149 621410..622537 1 NC_009567.1 COG3055 Uncharacterized protein conserved in bacteria; N-acetylneuraminic acid mutarotase 622537 5227149 CGSHiGG_03330 Haemophilus influenzae PittGG N-acetylneuraminic acid mutarotase YP_001292042.1 621410 D 374931 CDS YP_001292043.1 148827290 5227150 622699..623130 1 NC_009567.1 COG2020 Putative protein-S-isoprenylcysteine methyltransferase; putative protein-S-isoprenylcysteine methyltransferase 623130 5227150 CGSHiGG_03335 Haemophilus influenzae PittGG putative protein-S-isoprenylcysteine methyltransferase YP_001292043.1 622699 D 374931 CDS YP_001292044.1 148827291 5227151 complement(623174..624061) 1 NC_009567.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs; hypothetical protein 624061 5227151 CGSHiGG_03340 Haemophilus influenzae PittGG hypothetical protein YP_001292044.1 623174 R 374931 CDS YP_001292045.1 148827292 5227152 complement(624061..625281) 1 NC_009567.1 FtsH protease regulator HflK 625281 5227152 CGSHiGG_03345 Haemophilus influenzae PittGG FtsH protease regulator HflK YP_001292045.1 624061 R 374931 CDS YP_001292046.1 148827293 5227153 complement(626171..627502) 1 NC_009567.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter 627502 5227153 CGSHiGG_03360 Haemophilus influenzae PittGG anaerobic C4-dicarboxylate transporter YP_001292046.1 626171 R 374931 CDS YP_001292047.1 148827294 5227154 complement(627707..627937) 1 NC_009567.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 627937 acpP 5227154 acpP Haemophilus influenzae PittGG acyl carrier protein YP_001292047.1 627707 R 374931 CDS YP_001292048.1 148827295 5227155 complement(628193..628921) 1 NC_009567.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 628921 fabG 5227155 fabG Haemophilus influenzae PittGG 3-ketoacyl-(acyl-carrier-protein) reductase YP_001292048.1 628193 R 374931 CDS YP_001292049.1 148827296 5227156 complement(628938..629876) 1 NC_009567.1 COG0331 (acyl-carrier-protein) S-malonyltransferase; acyl carrier protein S-malonyltransferase 629876 5227156 CGSHiGG_03375 Haemophilus influenzae PittGG acyl carrier protein S-malonyltransferase YP_001292049.1 628938 R 374931 CDS YP_001292050.1 148827297 5227157 complement(630502..631452) 1 NC_009567.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III 631452 5227157 CGSHiGG_03380 Haemophilus influenzae PittGG 3-oxoacyl-(acyl carrier protein) synthase III YP_001292050.1 630502 R 374931 CDS YP_001292051.1 148827298 5227158 complement(631487..631588) 1 NC_009567.1 COG0332 3-oxoacyl-[acyl-carrier-protein] synthase III; hypothetical protein 631588 5227158 CGSHiGG_03385 Haemophilus influenzae PittGG hypothetical protein YP_001292051.1 631487 R 374931 CDS YP_001292052.1 148827299 5227159 complement(631638..631808) 1 NC_009567.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 631808 rpmF 5227159 rpmF Haemophilus influenzae PittGG 50S ribosomal protein L32 YP_001292052.1 631638 R 374931 CDS YP_001292053.1 148827300 5227160 complement(631851..632354) 1 NC_009567.1 COG1399 Predicted metal-binding, possibly nucleic acid-binding protein; hypothetical protein 632354 5227160 CGSHiGG_03395 Haemophilus influenzae PittGG hypothetical protein YP_001292053.1 631851 R 374931 CDS YP_001292054.1 148827301 5227161 complement(633492..634862) 1 NC_009567.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 634862 5227161 CGSHiGG_03410 Haemophilus influenzae PittGG glutathione reductase YP_001292054.1 633492 R 374931 CDS YP_001292055.1 148827302 5227162 complement(635079..635678) 1 NC_009567.1 COG3056 Uncharacterized lipoprotein; lipoprotein 635678 5227162 CGSHiGG_03415 Haemophilus influenzae PittGG lipoprotein YP_001292055.1 635079 R 374931 CDS YP_001292056.1 148827303 5227163 635772..636083 1 NC_009567.1 COG0271 Stress-induced morphogen (activity unknown); transcriptional regulator 636083 5227163 CGSHiGG_03420 Haemophilus influenzae PittGG transcriptional regulator YP_001292056.1 635772 D 374931 CDS YP_001292057.1 148827304 5227164 636375..637718 1 NC_009567.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit A 637718 5227164 CGSHiGG_03425 Haemophilus influenzae PittGG Na(+)-translocating NADH-quinone reductase subunit A YP_001292057.1 636375 D 374931 CDS YP_001292058.1 148827305 5227165 637721..638956 1 NC_009567.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit B 638956 5227165 CGSHiGG_03430 Haemophilus influenzae PittGG Na(+)-translocating NADH-quinone reductase subunit B YP_001292058.1 637721 D 374931 CDS YP_001292059.1 148827306 5227166 638949..639683 1 NC_009567.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit C 639683 5227166 CGSHiGG_03435 Haemophilus influenzae PittGG Na(+)-translocating NADH-quinone reductase subunit C YP_001292059.1 638949 D 374931 CDS YP_001292060.1 148827307 5227167 639683..640309 1 NC_009567.1 Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit D 640309 5227167 CGSHiGG_03440 Haemophilus influenzae PittGG Na(+)-translocating NADH-quinone reductase subunit D YP_001292060.1 639683 D 374931 CDS YP_001292061.1 148827308 5227168 640313..640909 1 NC_009567.1 Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.; Na(+)-translocating NADH-quinone reductase subunit E 640909 5227168 CGSHiGG_03445 Haemophilus influenzae PittGG Na(+)-translocating NADH-quinone reductase subunit E YP_001292061.1 640313 D 374931 CDS YP_001292062.1 148827309 5227169 640922..642157 1 NC_009567.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit F 642157 5227169 CGSHiGG_03450 Haemophilus influenzae PittGG Na(+)-translocating NADH-quinone reductase subunit F YP_001292062.1 640922 D 374931 CDS YP_001292063.1 148827310 5227170 642301..643341 1 NC_009567.1 COG1477 Membrane-associated lipoprotein involved in thiamine biosynthesis; thiamine biosynthesis lipoprotein ApbE 643341 5227170 CGSHiGG_03455 Haemophilus influenzae PittGG thiamine biosynthesis lipoprotein ApbE YP_001292063.1 642301 D 374931 CDS YP_001292064.1 148827311 5227171 643344..643604 1 NC_009567.1 COG2991 Uncharacterized protein conserved in bacteria; hypothetical protein 643604 5227171 CGSHiGG_03460 Haemophilus influenzae PittGG hypothetical protein YP_001292064.1 643344 D 374931 CDS YP_001292065.1 148827312 5227172 643721..644878 1 NC_009567.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 644878 mnmA 5227172 mnmA Haemophilus influenzae PittGG tRNA-specific 2-thiouridylase MnmA YP_001292065.1 643721 D 374931 CDS YP_001292066.1 148827313 5227173 complement(644922..645656) 1 NC_009567.1 COG1496 Uncharacterized conserved protein; hypothetical protein 645656 5227173 CGSHiGG_03470 Haemophilus influenzae PittGG hypothetical protein YP_001292066.1 644922 R 374931 CDS YP_001292067.1 148827314 5227174 complement(645658..646632) 1 NC_009567.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D 646632 rluD 5227174 rluD Haemophilus influenzae PittGG 23S rRNA pseudouridine synthase D YP_001292067.1 645658 R 374931 CDS YP_001292068.1 148827315 5227175 646740..647528 1 NC_009567.1 COG4105 DNA uptake lipoprotein; hypothetical protein 647528 5227175 CGSHiGG_03480 Haemophilus influenzae PittGG hypothetical protein YP_001292068.1 646740 D 374931 CDS YP_001292069.1 148827316 5227176 complement(647608..647952) 1 NC_009567.1 COG0525 Valyl-tRNA synthetase; hypothetical protein 647952 5227176 CGSHiGG_03485 Haemophilus influenzae PittGG hypothetical protein YP_001292069.1 647608 R 374931 CDS YP_001292070.1 148827317 5227177 complement(648121..648861) 1 NC_009567.1 activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 648861 pflA 5227177 pflA Haemophilus influenzae PittGG pyruvate formate lyase-activating enzyme 1 YP_001292070.1 648121 R 374931 CDS YP_001292071.1 148827318 5227178 complement(649014..651230) 1 NC_009567.1 COG1882 Pyruvate-formate lyase; formate acetyltransferase 651230 5227178 CGSHiGG_03495 Haemophilus influenzae PittGG formate acetyltransferase YP_001292071.1 649014 R 374931 CDS YP_001292072.1 148827319 5227179 complement(651193..651303) 1 NC_009567.1 COG1882 Pyruvate-formate lyase; formate acetyltransferase 651303 5227179 CGSHiGG_03500 Haemophilus influenzae PittGG formate acetyltransferase YP_001292072.1 651193 R 374931 CDS YP_001292073.1 148827320 5227180 complement(651341..652195) 1 NC_009567.1 COG2116 Formate/nitrite family of transporters; putative formate transporter 652195 5227180 CGSHiGG_03505 Haemophilus influenzae PittGG putative formate transporter YP_001292073.1 651341 R 374931 CDS YP_001292074.1 148827321 5227181 652700..653614 1 NC_009567.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 653614 5227181 CGSHiGG_03510 Haemophilus influenzae PittGG N-acetyl-D-glucosamine kinase YP_001292074.1 652700 D 374931 CDS YP_001292075.1 148827322 5227182 653798..655237 1 NC_009567.1 COG1115 Na+/alanine symporter; amino acid carrier protein 655237 5227182 CGSHiGG_03515 Haemophilus influenzae PittGG amino acid carrier protein YP_001292075.1 653798 D 374931 CDS YP_001292076.1 148827323 5227183 complement(655422..656249) 1 NC_009567.1 COG0627 Predicted esterase; esterase 656249 5227183 CGSHiGG_03520 Haemophilus influenzae PittGG esterase YP_001292076.1 655422 R 374931 CDS YP_001292077.1 148827324 5227184 complement(656258..657394) 1 NC_009567.1 COG1062 Zn-dependent alcohol dehydrogenases, class III; alcohol dehydrogenase class III 657394 5227184 CGSHiGG_03525 Haemophilus influenzae PittGG alcohol dehydrogenase class III YP_001292077.1 656258 R 374931 CDS YP_001292078.1 148827325 5227185 657517..657924 1 NC_009567.1 COG0789 Predicted transcriptional regulators; putative HTH-type transcriptional regulator 657924 5227185 CGSHiGG_03530 Haemophilus influenzae PittGG putative HTH-type transcriptional regulator YP_001292078.1 657517 D 374931 CDS YP_001292079.1 148827326 5227186 658192..658368 1 NC_009567.1 COG1826 Sec-independent protein secretion pathway components; Sec-independent protein translocase protein TatA/E 658368 5227186 CGSHiGG_03535 Haemophilus influenzae PittGG Sec-independent protein translocase protein TatA/E YP_001292079.1 658192 D 374931 CDS YP_001292080.1 148827327 5227187 658372..658932 1 NC_009567.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 658932 5227187 CGSHiGG_03540 Haemophilus influenzae PittGG sec-independent translocase YP_001292080.1 658372 D 374931 CDS YP_001292081.1 148827328 5227188 658942..659721 1 NC_009567.1 COG0805 Sec-independent protein secretion pathway component TatC; Sec-independent protein translocase protein TatC 659721 5227188 CGSHiGG_03545 Haemophilus influenzae PittGG Sec-independent protein translocase protein TatC YP_001292081.1 658942 D 374931 CDS YP_001292082.1 148827329 5227189 complement(661527..661967) 1 NC_009567.1 COG0735 Fe2+/Zn2+ uptake regulation proteins; ferric uptake regulation protein 661967 5227189 CGSHiGG_03560 Haemophilus influenzae PittGG ferric uptake regulation protein YP_001292082.1 661527 R 374931 CDS YP_001292083.1 148827330 5227190 complement(661996..662520) 1 NC_009567.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA 662520 5227190 CGSHiGG_03565 Haemophilus influenzae PittGG flavodoxin FldA YP_001292083.1 661996 R 374931 CDS YP_001292084.1 148827331 5227191 complement(662617..663399) 1 NC_009567.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); esterase/lipase 663399 5227191 CGSHiGG_03570 Haemophilus influenzae PittGG esterase/lipase YP_001292084.1 662617 R 374931 CDS YP_001292085.1 148827332 5227192 663470..664063 1 NC_009567.1 negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 664063 5227192 CGSHiGG_03575 Haemophilus influenzae PittGG replication initiation regulator SeqA YP_001292085.1 663470 D 374931 CDS YP_001292086.1 148827333 5227193 664066..665424 1 NC_009567.1 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; O-succinylbenzoic acid--CoA ligase 665424 5227193 CGSHiGG_03580 Haemophilus influenzae PittGG O-succinylbenzoic acid--CoA ligase YP_001292086.1 664066 D 374931 CDS YP_001292087.1 148827334 5227194 665466..668786 1 NC_009567.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 668786 5227194 CGSHiGG_03585 Haemophilus influenzae PittGG potassium efflux protein KefA YP_001292087.1 665466 D 374931 CDS YP_001292088.1 148827335 5227195 668796..669869 1 NC_009567.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 669869 5227195 CGSHiGG_03590 Haemophilus influenzae PittGG chorismate synthase YP_001292088.1 668796 D 374931 CDS YP_001292089.1 148827336 5227196 670042..670902 1 NC_009567.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 670902 mepA 5227196 mepA Haemophilus influenzae PittGG penicillin-insensitive murein endopeptidase YP_001292089.1 670042 D 374931 CDS YP_001292090.1 148827337 5227197 671735..672691 1 NC_009567.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 672691 5227197 CGSHiGG_03610 Haemophilus influenzae PittGG lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_001292090.1 671735 D 374931 CDS YP_001292091.1 148827338 5227198 672818..673789 1 NC_009567.1 catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 673789 5227198 CGSHiGG_03615 Haemophilus influenzae PittGG selenophosphate synthetase YP_001292091.1 672818 D 374931 CDS YP_001292092.1 148827339 5227199 complement(673902..674252) 1 NC_009567.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 674252 rplS 5227199 rplS Haemophilus influenzae PittGG 50S ribosomal protein L19 YP_001292092.1 673902 R 374931 CDS YP_001292093.1 148827340 5227200 complement(674289..675029) 1 NC_009567.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 675029 trmD 5227200 trmD Haemophilus influenzae PittGG tRNA (guanine-N(1)-)-methyltransferase YP_001292093.1 674289 R 374931 CDS YP_001292094.1 148827341 5227201 complement(675067..675594) 1 NC_009567.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 675594 rimM 5227201 rimM Haemophilus influenzae PittGG 16S rRNA-processing protein RimM YP_001292094.1 675067 R 374931 CDS YP_001292095.1 148827342 5227202 complement(675639..675887) 1 NC_009567.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 675887 rpsP 5227202 rpsP Haemophilus influenzae PittGG 30S ribosomal protein S16 YP_001292095.1 675639 R 374931 CDS YP_001292096.1 148827343 5227203 676180..676953 1 NC_009567.1 COG0228 Ribosomal protein S16; hypothetical protein 676953 5227203 CGSHiGG_03640 Haemophilus influenzae PittGG hypothetical protein YP_001292096.1 676180 D 374931 CDS YP_001292097.1 148827344 5227204 676976..678787 1 NC_009567.1 COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; NAD nucleotidase 678787 5227204 CGSHiGG_03645 Haemophilus influenzae PittGG NAD nucleotidase YP_001292097.1 676976 D 374931 CDS YP_001292098.1 148827345 5227205 679072..679614 1 NC_009567.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 679614 aroK 5227205 aroK Haemophilus influenzae PittGG shikimate kinase YP_001292098.1 679072 D 374931 CDS YP_001292099.1 148827346 5227206 679634..680722 1 NC_009567.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 680722 aroB 5227206 aroB Haemophilus influenzae PittGG 3-dehydroquinate synthase YP_001292099.1 679634 D 374931 CDS YP_001292100.1 148827347 5227207 680724..681584 1 NC_009567.1 DNA adenine methylase 681584 5227207 CGSHiGG_03660 Haemophilus influenzae PittGG DNA adenine methylase YP_001292100.1 680724 D 374931 CDS YP_001292101.1 148827348 5227208 682518..682625 1 NC_009567.1 COG0338 Site-specific DNA methylase; hypothetical protein 682625 5227208 CGSHiGG_03665 Haemophilus influenzae PittGG hypothetical protein YP_001292101.1 682518 D 374931 CDS YP_001292102.1 148827349 5227209 complement(682644..683369) 1 NC_009567.1 COG0671 Membrane-associated phospholipid phosphatase; phosphatidylglycerophosphatase B 683369 5227209 CGSHiGG_03670 Haemophilus influenzae PittGG phosphatidylglycerophosphatase B YP_001292102.1 682644 R 374931 CDS YP_001292103.1 148827350 5227210 683438..684088 1 NC_009567.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 684088 ribA 5227210 ribA Haemophilus influenzae PittGG GTP cyclohydrolase II YP_001292103.1 683438 D 374931 CDS YP_001292104.1 148827351 5227211 complement(684411..685955) 1 NC_009567.1 COG4166 ABC-type oligopeptide transport system, periplasmic component; oligopeptide transporter periplasmic-binding protein 685955 5227211 CGSHiGG_03680 Haemophilus influenzae PittGG oligopeptide transporter periplasmic-binding protein YP_001292104.1 684411 R 374931 CDS YP_001292105.1 148827352 5227212 complement(685948..686310) 1 NC_009567.1 COG2832 Uncharacterized protein conserved in bacteria; hypothetical protein 686310 5227212 CGSHiGG_03685 Haemophilus influenzae PittGG hypothetical protein YP_001292105.1 685948 R 374931 CDS YP_001292106.1 148827353 5227213 686436..688475 1 NC_009567.1 COG0339 Zn-dependent oligopeptidases; oligopeptidase A 688475 5227213 CGSHiGG_03690 Haemophilus influenzae PittGG oligopeptidase A YP_001292106.1 686436 D 374931 CDS YP_001292107.1 148827354 5227214 688707..690251 1 NC_009567.1 COG0286 Type I restriction-modification system methyltransferase subunit; putative type I restriction-modification system methyltransferase subunit 690251 5227214 CGSHiGG_03695 Haemophilus influenzae PittGG putative type I restriction-modification system methyltransferase subunit YP_001292107.1 688707 D 374931 CDS YP_001292108.1 148827355 5227215 690386..691558 1 NC_009567.1 COG0732 Restriction endonuclease S subunits; putative type I restriction-modification system, specificity determinant; restriction endonuclease 691558 5227215 CGSHiGG_03700 Haemophilus influenzae PittGG putative type I restriction-modification system, specificity determinant; restriction endonuclease YP_001292108.1 690386 D 374931 CDS YP_001292109.1 148827356 5227216 691724..692254 1 NC_009567.1 COG1943 Transposase and inactivated derivatives; hypothetical protein 692254 5227216 CGSHiGG_03705 Haemophilus influenzae PittGG hypothetical protein YP_001292109.1 691724 D 374931 CDS YP_001292110.1 148827357 5227217 692359..695442 1 NC_009567.1 COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases; putative type I restriction-modification system 695442 5227217 CGSHiGG_03710 Haemophilus influenzae PittGG putative type I restriction-modification system YP_001292110.1 692359 D 374931 CDS YP_001292111.1 148827358 5227218 complement(695590..696219) 1 NC_009567.1 COG3059 Predicted membrane protein; hypothetical protein 696219 5227218 CGSHiGG_03715 Haemophilus influenzae PittGG hypothetical protein YP_001292111.1 695590 R 374931 CDS YP_001292112.1 148827359 5227219 complement(696432..698228) 1 NC_009567.1 COG0642 Signal transduction histidine kinase; aerobic respiration control sensor protein ArcB 698228 5227219 CGSHiGG_03720 Haemophilus influenzae PittGG aerobic respiration control sensor protein ArcB YP_001292112.1 696432 R 374931 CDS YP_001292113.1 148827360 5227220 complement(698341..698928) 1 NC_009567.1 COG1573 Uracil-DNA glycosylase; uracil-DNA glycosylase 698928 5227220 CGSHiGG_03725 Haemophilus influenzae PittGG uracil-DNA glycosylase YP_001292113.1 698341 R 374931 CDS YP_001292114.1 148827361 5227223 complement(705038..705943) 1 NC_009567.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 705943 5227223 CGSHiGG_03730 Haemophilus influenzae PittGG biotin--protein ligase YP_001292114.1 705038 R 374931 CDS YP_001292115.1 148827362 5227224 706073..707539 1 NC_009567.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 707539 5227224 CGSHiGG_03735 Haemophilus influenzae PittGG inosine 5'-monophosphate dehydrogenase YP_001292115.1 706073 D 374931 CDS YP_001292116.1 148827363 5227225 707649..709220 1 NC_009567.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 709220 guaA 5227225 guaA Haemophilus influenzae PittGG GMP synthase YP_001292116.1 707649 D 374931 CDS YP_001292117.1 148827364 5227226 complement(709282..710172) 1 NC_009567.1 COG2962 Predicted permeases; hypothetical protein 710172 5227226 CGSHiGG_03745 Haemophilus influenzae PittGG hypothetical protein YP_001292117.1 709282 R 374931 CDS YP_001292118.1 148827365 5227227 710292..710753 1 NC_009567.1 COG1522 Transcriptional regulators; putative transcriptional regulator 710753 5227227 CGSHiGG_03750 Haemophilus influenzae PittGG putative transcriptional regulator YP_001292118.1 710292 D 374931 CDS YP_001292119.1 148827366 5227228 complement(710792..711994) 1 NC_009567.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 711994 5227228 CGSHiGG_03755 Haemophilus influenzae PittGG pH-dependent sodium/proton antiporter YP_001292119.1 710792 R 374931 CDS YP_001292120.1 148827367 5227229 712150..713493 1 NC_009567.1 COG1114 Branched-chain amino acid permeases; branched-chain amino acid transport system II carrier protein 713493 5227229 CGSHiGG_03760 Haemophilus influenzae PittGG branched-chain amino acid transport system II carrier protein YP_001292120.1 712150 D 374931 CDS YP_001292121.1 148827368 5227230 complement(713601..714068) 1 NC_009567.1 hypothetical protein 714068 5227230 CGSHiGG_03765 Haemophilus influenzae PittGG hypothetical protein YP_001292121.1 713601 R 374931 CDS YP_001292122.1 148827369 5227231 complement(714144..714515) 1 NC_009567.1 COG2731 Beta-galactosidase, beta subunit; hypothetical protein 714515 5227231 CGSHiGG_03770 Haemophilus influenzae PittGG hypothetical protein YP_001292122.1 714144 R 374931 CDS YP_001292123.1 148827370 5227232 714826..716955 1 NC_009567.1 polynucleotide phosphorylase/polyadenylase 716955 5227232 CGSHiGG_03775 Haemophilus influenzae PittGG polynucleotide phosphorylase/polyadenylase YP_001292123.1 714826 D 374931 CDS YP_001292124.1 148827371 5227233 718101..719942 1 NC_009567.1 COG0513 Superfamily II DNA and RNA helicases; ATP-dependent RNA helicase 719942 5227233 CGSHiGG_03790 Haemophilus influenzae PittGG ATP-dependent RNA helicase YP_001292124.1 718101 D 374931 CDS YP_001292125.1 148827372 5227234 720061..721509 1 NC_009567.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; putative transglycosylase 721509 5227234 CGSHiGG_03795 Haemophilus influenzae PittGG putative transglycosylase YP_001292125.1 720061 D 374931 CDS YP_001292126.1 148827373 5227235 721514..721666 1 NC_009567.1 hypothetical protein 721666 5227235 CGSHiGG_03800 Haemophilus influenzae PittGG hypothetical protein YP_001292126.1 721514 D 374931 CDS YP_001292127.1 148827374 5227236 complement(721801..722097) 1 NC_009567.1 COG4623 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein; hypothetical protein 722097 5227236 CGSHiGG_03805 Haemophilus influenzae PittGG hypothetical protein YP_001292127.1 721801 R 374931 CDS YP_001292128.1 148827375 5227237 complement(722116..722361) 1 NC_009567.1 COG3036 Uncharacterized protein conserved in bacteria; hypothetical protein 722361 5227237 CGSHiGG_03810 Haemophilus influenzae PittGG hypothetical protein YP_001292128.1 722116 R 374931 CDS YP_001292129.1 148827376 5227238 complement(722429..722779) 1 NC_009567.1 COG1393 Arsenate reductase and related proteins, glutaredoxin family; arsenate reductase 722779 5227238 CGSHiGG_03815 Haemophilus influenzae PittGG arsenate reductase YP_001292129.1 722429 R 374931 CDS YP_001292130.1 148827377 5227239 722857..723906 1 NC_009567.1 COG0628 Predicted permease; hypothetical protein 723906 5227239 CGSHiGG_03820 Haemophilus influenzae PittGG hypothetical protein YP_001292130.1 722857 D 374931 CDS YP_001292131.1 148827378 5227240 complement(724020..724994) 1 NC_009567.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 724994 secF 5227240 secF Haemophilus influenzae PittGG preprotein translocase subunit SecF YP_001292131.1 724020 R 374931 CDS YP_001292132.1 148827379 5227241 complement(725005..726855) 1 NC_009567.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 726855 secD 5227241 secD Haemophilus influenzae PittGG preprotein translocase subunit SecD YP_001292132.1 725005 R 374931 CDS YP_001292133.1 148827380 5227242 complement(726925..727218) 1 NC_009567.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 727218 yajC 5227242 yajC Haemophilus influenzae PittGG preprotein translocase subunit YajC YP_001292133.1 726925 R 374931 CDS YP_001292134.1 148827381 5227243 complement(727326..727547) 1 NC_009567.1 COG0425 Predicted redox protein, regulator of disulfide bond formation; hypothetical protein 727547 5227243 CGSHiGG_03840 Haemophilus influenzae PittGG hypothetical protein YP_001292134.1 727326 R 374931 CDS YP_001292135.1 148827382 5227244 complement(727544..728062) 1 NC_009567.1 COG0457 FOG: TPR repeat; hypothetical protein 728062 5227244 CGSHiGG_03845 Haemophilus influenzae PittGG hypothetical protein YP_001292135.1 727544 R 374931 CDS YP_001292136.1 148827383 5227245 complement(728127..729275) 1 NC_009567.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 729275 tgt 5227245 tgt Haemophilus influenzae PittGG queuine tRNA-ribosyltransferase YP_001292136.1 728127 R 374931 CDS YP_001292137.1 148827384 5227246 complement(729618..730709) 1 NC_009567.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 730709 queA 5227246 queA Haemophilus influenzae PittGG S-adenosylmethionine:tRNA ribosyltransferase-isomerase YP_001292137.1 729618 R 374931 CDS YP_001292138.1 148827385 5227247 complement(730833..731279) 1 NC_009567.1 COG0809 S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase); hypothetical protein 731279 5227247 CGSHiGG_03860 Haemophilus influenzae PittGG hypothetical protein YP_001292138.1 730833 R 374931 CDS YP_001292139.1 148827386 5227248 complement(735942..738773) 1 NC_009567.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 738773 uvrA 5227248 uvrA Haemophilus influenzae PittGG excinuclease ABC subunit A YP_001292139.1 735942 R 374931 CDS YP_001292140.1 148827387 5227249 738927..739433 1 NC_009567.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 739433 5227249 CGSHiGG_03885 Haemophilus influenzae PittGG single-stranded DNA-binding protein YP_001292140.1 738927 D 374931 CDS YP_001292141.1 148827388 5227250 739581..740813 1 NC_009567.1 COG0582 Integrase; hypothetical protein 740813 5227250 CGSHiGG_03890 Haemophilus influenzae PittGG hypothetical protein YP_001292141.1 739581 D 374931 CDS YP_001292142.1 148827389 5227251 744414..744824 1 NC_009567.1 COG4688 Uncharacterized protein conserved in bacteria; hypothetical protein 744824 5227251 CGSHiGG_03915 Haemophilus influenzae PittGG hypothetical protein YP_001292142.1 744414 D 374931 CDS YP_001292143.1 148827390 5227252 complement(745198..746280) 1 NC_009567.1 COG3621 Patatin; patatin 746280 5227252 CGSHiGG_03920 Haemophilus influenzae PittGG patatin YP_001292143.1 745198 R 374931 CDS YP_001292144.1 148827391 5227253 complement(746264..747103) 1 NC_009567.1 COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1; hypothetical protein 747103 5227253 CGSHiGG_03925 Haemophilus influenzae PittGG hypothetical protein YP_001292144.1 746264 R 374931 CDS YP_001292145.1 148827392 5227254 complement(747141..747989) 1 NC_009567.1 hypothetical protein 747989 5227254 CGSHiGG_03930 Haemophilus influenzae PittGG hypothetical protein YP_001292145.1 747141 R 374931 CDS YP_001292146.1 148827393 5227255 complement(747973..748326) 1 NC_009567.1 hypothetical protein 748326 5227255 CGSHiGG_03935 Haemophilus influenzae PittGG hypothetical protein YP_001292146.1 747973 R 374931 CDS YP_001292147.1 148827394 5227256 complement(750612..751406) 1 NC_009567.1 COG0810 Periplasmic protein TonB, links inner and outer membranes; TonB 751406 5227256 CGSHiGG_03950 Haemophilus influenzae PittGG TonB YP_001292147.1 750612 R 374931 CDS YP_001292148.1 148827395 5227257 complement(751416..751859) 1 NC_009567.1 COG0848 Biopolymer transport protein; biopolymer transport protein 751859 5227257 CGSHiGG_03955 Haemophilus influenzae PittGG biopolymer transport protein YP_001292148.1 751416 R 374931 CDS YP_001292149.1 148827396 5227258 complement(751863..752315) 1 NC_009567.1 COG0811 Biopolymer transport proteins; transport protein ExbB 752315 5227258 CGSHiGG_03960 Haemophilus influenzae PittGG transport protein ExbB YP_001292149.1 751863 R 374931 CDS YP_001292150.1 148827397 5227259 complement(752484..752951) 1 NC_009567.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 752951 bcp 5227259 bcp Haemophilus influenzae PittGG thioredoxin-dependent thiol peroxidase YP_001292150.1 752484 R 374931 CDS YP_001292151.1 148827398 5227260 753052..753948 1 NC_009567.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 753948 5227260 CGSHiGG_03970 Haemophilus influenzae PittGG dihydrodipicolinate synthase YP_001292151.1 753052 D 374931 CDS YP_001292152.1 148827399 5227261 754059..754706 1 NC_009567.1 COG3317 Uncharacterized lipoprotein; lipoprotein 754706 5227261 CGSHiGG_03975 Haemophilus influenzae PittGG lipoprotein YP_001292152.1 754059 D 374931 CDS YP_001292153.1 148827400 5227262 754879..755202 1 NC_009567.1 COG1544 Ribosome-associated protein Y (PSrp-1); hypothetical protein 755202 5227262 CGSHiGG_03980 Haemophilus influenzae PittGG hypothetical protein YP_001292153.1 754879 D 374931 CDS YP_001292154.1 148827401 5227263 complement(755803..756093) 1 NC_009567.1 COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system; hypothetical protein 756093 5227263 CGSHiGG_03985 Haemophilus influenzae PittGG hypothetical protein YP_001292154.1 755803 R 374931 CDS YP_001292155.1 148827402 5227264 complement(756083..756337) 1 NC_009567.1 COG2161 Antitoxin of toxin-antitoxin stability system; hypothetical protein 756337 5227264 CGSHiGG_03990 Haemophilus influenzae PittGG hypothetical protein YP_001292155.1 756083 R 374931 CDS YP_001292156.1 148827403 5227265 complement(756833..759040) 1 NC_009567.1 hypothetical protein 759040 5227265 CGSHiGG_03995 Haemophilus influenzae PittGG hypothetical protein YP_001292156.1 756833 R 374931 CDS YP_001292157.1 148827404 5227266 complement(759050..759328) 1 NC_009567.1 hypothetical protein 759328 5227266 CGSHiGG_04000 Haemophilus influenzae PittGG hypothetical protein YP_001292157.1 759050 R 374931 CDS YP_001292158.1 148827405 5227267 complement(759337..759561) 1 NC_009567.1 hypothetical protein 759561 5227267 CGSHiGG_04005 Haemophilus influenzae PittGG hypothetical protein YP_001292158.1 759337 R 374931 CDS YP_001292159.1 148827406 5227268 complement(759558..760382) 1 NC_009567.1 hypothetical protein 760382 5227268 CGSHiGG_04010 Haemophilus influenzae PittGG hypothetical protein YP_001292159.1 759558 R 374931 CDS YP_001292160.1 148827407 5227269 complement(760442..760672) 1 NC_009567.1 COG5519 Superfamily II helicase and inactivated derivatives; hypothetical protein 760672 5227269 CGSHiGG_04015 Haemophilus influenzae PittGG hypothetical protein YP_001292160.1 760442 R 374931 CDS YP_001292161.1 148827408 5227270 complement(760653..760868) 1 NC_009567.1 hypothetical protein 760868 5227270 CGSHiGG_04020 Haemophilus influenzae PittGG hypothetical protein YP_001292161.1 760653 R 374931 CDS YP_001292162.1 148827409 5227271 complement(760936..761100) 1 NC_009567.1 hypothetical protein 761100 5227271 CGSHiGG_04025 Haemophilus influenzae PittGG hypothetical protein YP_001292162.1 760936 R 374931 CDS YP_001292163.1 148827410 5227272 complement(762573..762998) 1 NC_009567.1 COG0553 Superfamily II DNA/RNA helicases, SNF2 family; hypothetical protein 762998 5227272 CGSHiGG_04040 Haemophilus influenzae PittGG hypothetical protein YP_001292163.1 762573 R 374931 CDS YP_001292164.1 148827411 5227273 complement(762973..763617) 1 NC_009567.1 COG1196 Chromosome segregation ATPases; hypothetical protein 763617 5227273 CGSHiGG_04045 Haemophilus influenzae PittGG hypothetical protein YP_001292164.1 762973 R 374931 CDS YP_001292165.1 148827412 5227274 complement(763951..764496) 1 NC_009567.1 COG1196 Chromosome segregation ATPases; hypothetical protein 764496 5227274 CGSHiGG_04050 Haemophilus influenzae PittGG hypothetical protein YP_001292165.1 763951 R 374931 CDS YP_001292166.1 148827413 5227275 complement(764498..764713) 1 NC_009567.1 transcriptional regulator 764713 5227275 CGSHiGG_04055 Haemophilus influenzae PittGG transcriptional regulator YP_001292166.1 764498 R 374931 CDS YP_001292167.1 148827414 5227276 765188..765433 1 NC_009567.1 COG3311 Predicted transcriptional regulator; putative phage gene 765433 5227276 CGSHiGG_04060 Haemophilus influenzae PittGG putative phage gene YP_001292167.1 765188 D 374931 CDS YP_001292168.1 148827415 5227277 complement(765439..766458) 1 NC_009567.1 COG0582 Integrase; prophage integrase 766458 5227277 CGSHiGG_04065 Haemophilus influenzae PittGG prophage integrase YP_001292168.1 765439 R 374931 CDS YP_001292169.1 148827416 5227278 complement(768201..768788) 1 NC_009567.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 768788 5227278 CGSHiGG_04080 Haemophilus influenzae PittGG putative deoxyribonucleotide triphosphate pyrophosphatase YP_001292169.1 768201 R 374931 CDS YP_001292170.1 148827417 5227279 complement(768799..769524) 1 NC_009567.1 catalyzes the phosphorylation of 3-deoxy-D-manno-octulosonic acid at the 4-OH position; 3-deoxy-D-manno-octulosonic-acid kinase 769524 5227279 CGSHiGG_04085 Haemophilus influenzae PittGG 3-deoxy-D-manno-octulosonic-acid kinase YP_001292170.1 768799 R 374931 CDS YP_001292171.1 148827418 5227280 769601..770644 1 NC_009567.1 COG0859 ADP-heptose:LPS heptosyltransferase; ADP-heptose--lipooligosaccharide heptosyltransferase I 770644 5227280 CGSHiGG_04090 Haemophilus influenzae PittGG ADP-heptose--lipooligosaccharide heptosyltransferase I YP_001292171.1 769601 D 374931 CDS YP_001292172.1 148827419 5227281 770979..773135 1 NC_009567.1 COG1629 Outer membrane receptor proteins, mostly Fe transport; heme-hemopexin utilization protein C 773135 5227281 CGSHiGG_04095 Haemophilus influenzae PittGG heme-hemopexin utilization protein C YP_001292172.1 770979 D 374931 CDS YP_001292173.1 148827420 5227282 773217..774908 1 NC_009567.1 COG2831 Hemolysin activation/secretion protein; heme/hemopexin-binding protein B 774908 5227282 CGSHiGG_04100 Haemophilus influenzae PittGG heme/hemopexin-binding protein B YP_001292173.1 773217 D 374931 CDS YP_001292174.1 148827421 5227283 complement(777768..778124) 1 NC_009567.1 COG1539 Dihydroneopterin aldolase; dihydroneopterin aldolase 778124 5227283 CGSHiGG_04115 Haemophilus influenzae PittGG dihydroneopterin aldolase YP_001292174.1 777768 R 374931 CDS YP_001292175.1 148827422 5227284 778207..778806 1 NC_009567.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY 778806 5227284 CGSHiGG_04120 Haemophilus influenzae PittGG putative glycerol-3-phosphate acyltransferase PlsY YP_001292175.1 778207 D 374931 CDS YP_001292176.1 148827423 5227285 778847..780550 1 NC_009567.1 COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific; nitrate/nitrite sensor protein NarQ 780550 5227285 CGSHiGG_04125 Haemophilus influenzae PittGG nitrate/nitrite sensor protein NarQ YP_001292176.1 778847 D 374931 CDS YP_001292177.1 148827424 5227286 781710..782555 1 NC_009567.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 782555 5227286 CGSHiGG_04140 Haemophilus influenzae PittGG RNA polymerase factor sigma-32 YP_001292177.1 781710 D 374931 CDS YP_001292178.1 148827425 5227287 complement(783022..783888) 1 NC_009567.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 783888 djlA 5227287 djlA Haemophilus influenzae PittGG Dna-J like membrane chaperone protein YP_001292178.1 783022 R 374931 CDS YP_001292179.1 148827426 5227288 complement(783955..784596) 1 NC_009567.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 784596 pyrE 5227288 pyrE Haemophilus influenzae PittGG orotate phosphoribosyltransferase YP_001292179.1 783955 R 374931 CDS YP_001292180.1 148827427 5227289 complement(784620..785336) 1 NC_009567.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 785336 rph 5227289 rph Haemophilus influenzae PittGG ribonuclease PH YP_001292180.1 784620 R 374931 CDS YP_001292181.1 148827428 5227290 complement(785639..787081) 1 NC_009567.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 787081 gltX 5227290 gltX Haemophilus influenzae PittGG glutamyl-tRNA synthetase YP_001292181.1 785639 R 374931 CDS YP_001292182.1 148827429 5227291 787830..789485 1 NC_009567.1 COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily; hypothetical protein 789485 5227291 CGSHiGG_04175 Haemophilus influenzae PittGG hypothetical protein YP_001292182.1 787830 D 374931 CDS YP_001292183.1 148827430 5227292 complement(789505..790314) 1 NC_009567.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 790314 rbn 5227292 rbn Haemophilus influenzae PittGG ribonuclease BN YP_001292183.1 789505 R 374931 CDS YP_001292184.1 148827431 5227293 complement(790311..790793) 1 NC_009567.1 COG3012 Uncharacterized protein conserved in bacteria; hypothetical protein 790793 5227293 CGSHiGG_04185 Haemophilus influenzae PittGG hypothetical protein YP_001292184.1 790311 R 374931 CDS YP_001292185.1 148827432 5227294 complement(790893..791459) 1 NC_009567.1 COG2258 Uncharacterized protein conserved in bacteria; hypothetical protein 791459 5227294 CGSHiGG_04190 Haemophilus influenzae PittGG hypothetical protein YP_001292185.1 790893 R 374931 CDS YP_001292186.1 148827433 5227295 791695..792453 1 NC_009567.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 792453 5227295 CGSHiGG_04195 Haemophilus influenzae PittGG uridine phosphorylase YP_001292186.1 791695 D 374931 CDS YP_001292187.1 148827434 5227296 complement(792679..793995) 1 NC_009567.1 COG0477 Permeases of the major facilitator superfamily; transport protein 793995 5227296 CGSHiGG_04200 Haemophilus influenzae PittGG transport protein YP_001292187.1 792679 R 374931 CDS YP_001292188.1 148827435 5227297 complement(794051..794794) 1 NC_009567.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase YfbB 794794 5227297 CGSHiGG_04205 Haemophilus influenzae PittGG acyl-CoA thioester hydrolase YfbB YP_001292188.1 794051 R 374931 CDS YP_001292189.1 148827436 5227298 complement(794856..796562) 1 NC_009567.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 796562 5227298 CGSHiGG_04210 Haemophilus influenzae PittGG 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase YP_001292189.1 794856 R 374931 CDS YP_001292190.1 148827437 5227299 complement(796578..797735) 1 NC_009567.1 menaquinone-specific isochorismate synthase 797735 5227299 CGSHiGG_04215 Haemophilus influenzae PittGG menaquinone-specific isochorismate synthase YP_001292190.1 796578 R 374931 CDS YP_001292191.1 148827438 5227300 797783..798052 1 NC_009567.1 COG1169 Isochorismate synthase; hypothetical protein 798052 5227300 CGSHiGG_04220 Haemophilus influenzae PittGG hypothetical protein YP_001292191.1 797783 D 374931 CDS YP_001292192.1 148827439 5227301 798006..799277 1 NC_009567.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 799277 5227301 CGSHiGG_04225 Haemophilus influenzae PittGG aminotransferase AlaT YP_001292192.1 798006 D 374931 CDS YP_001292193.1 148827440 5227306 799378..800595 1 NC_009567.1 COG0814 Amino acid permeases; tryptophan-specific transport protein 800595 5227306 CGSHiGG_04230 Haemophilus influenzae PittGG tryptophan-specific transport protein YP_001292193.1 799378 D 374931 CDS YP_001292194.1 148827441 5227307 complement(802106..803344) 1 NC_009567.1 COG0814 Amino acid permeases; serine transporter 803344 5227307 CGSHiGG_04250 Haemophilus influenzae PittGG serine transporter YP_001292194.1 802106 R 374931 CDS YP_001292195.1 148827442 5227308 complement(803567..805735) 1 NC_009567.1 COG2217 Cation transport ATPase; putative cation-transporting ATPase 805735 5227308 CGSHiGG_04255 Haemophilus influenzae PittGG putative cation-transporting ATPase YP_001292195.1 803567 R 374931 CDS YP_001292196.1 148827443 5227309 complement(805710..805916) 1 NC_009567.1 COG2608 Copper chaperone; mercuric ion scavenger protein 805916 5227309 CGSHiGG_04260 Haemophilus influenzae PittGG mercuric ion scavenger protein YP_001292196.1 805710 R 374931 CDS YP_001292197.1 148827444 5227310 complement(806002..806208) 1 NC_009567.1 COG2608 Copper chaperone; mercuric ion scavenger protein 806208 5227310 CGSHiGG_04265 Haemophilus influenzae PittGG mercuric ion scavenger protein YP_001292197.1 806002 R 374931 CDS YP_001292198.1 148827445 5227311 complement(806294..806500) 1 NC_009567.1 COG2608 Copper chaperone; mercuric ion scavenger protein 806500 5227311 CGSHiGG_04270 Haemophilus influenzae PittGG mercuric ion scavenger protein YP_001292198.1 806294 R 374931 CDS YP_001292199.1 148827446 5227312 complement(806574..806780) 1 NC_009567.1 COG2608 Copper chaperone; mercuric ion scavenger protein 806780 5227312 CGSHiGG_04275 Haemophilus influenzae PittGG mercuric ion scavenger protein YP_001292199.1 806574 R 374931 CDS YP_001292200.1 148827447 5227313 806857..807243 1 NC_009567.1 COG0789 Predicted transcriptional regulators; transcriptional regulator MerR family protein 807243 5227313 CGSHiGG_04280 Haemophilus influenzae PittGG transcriptional regulator MerR family protein YP_001292200.1 806857 D 374931 CDS YP_001292201.1 148827448 5227314 complement(807257..807466) 1 NC_009567.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ 807466 5227314 CGSHiGG_04285 Haemophilus influenzae PittGG transcriptional repressor protein MetJ YP_001292201.1 807257 R 374931 CDS YP_001292202.1 148827449 5227315 807824..809086 1 NC_009567.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 809086 rho 5227315 rho Haemophilus influenzae PittGG transcription termination factor Rho YP_001292202.1 807824 D 374931 CDS YP_001292203.1 148827450 5227316 complement(809188..809832) 1 NC_009567.1 COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases; putative type 4 prepilin-like protein specific leader peptidase 809832 5227316 CGSHiGG_04295 Haemophilus influenzae PittGG putative type 4 prepilin-like protein specific leader peptidase YP_001292203.1 809188 R 374931 CDS YP_001292204.1 148827451 5227317 complement(809829..811049) 1 NC_009567.1 COG1459 Type II secretory pathway, component PulF; putative type IV pilin secretion protein 811049 5227317 CGSHiGG_04300 Haemophilus influenzae PittGG putative type IV pilin secretion protein YP_001292204.1 809829 R 374931 CDS YP_001292205.1 148827452 5227318 complement(811046..812440) 1 NC_009567.1 COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB; protein transport protein 812440 5227318 CGSHiGG_04305 Haemophilus influenzae PittGG protein transport protein YP_001292205.1 811046 R 374931 CDS YP_001292206.1 148827453 5227319 complement(812437..812886) 1 NC_009567.1 COG4969 Tfp pilus assembly protein, major pilin PilA; prepilin peptidase-dependent protein D 812886 5227319 CGSHiGG_04310 Haemophilus influenzae PittGG prepilin peptidase-dependent protein D YP_001292206.1 812437 R 374931 CDS YP_001292207.1 148827454 5227320 813001..813564 1 NC_009567.1 COG3023 Negative regulator of beta-lactamase expression; N-acetyl-anhydromuranmyl-L-alanine amidase 813564 5227320 CGSHiGG_04315 Haemophilus influenzae PittGG N-acetyl-anhydromuranmyl-L-alanine amidase YP_001292207.1 813001 D 374931 CDS YP_001292208.1 148827455 5227321 814186..815085 1 NC_009567.1 COG4535 Putative Mg2+ and Co2+ transporter CorC; magnesium and cobalt efflux protein CorC 815085 5227321 CGSHiGG_04320 Haemophilus influenzae PittGG magnesium and cobalt efflux protein CorC YP_001292208.1 814186 D 374931 CDS YP_001292209.1 148827456 5227322 815069..816637 1 NC_009567.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 816637 lnt 5227322 lnt Haemophilus influenzae PittGG apolipoprotein N-acyltransferase YP_001292209.1 815069 D 374931 CDS YP_001292210.1 148827457 5227323 816687..817424 1 NC_009567.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 817424 5227323 CGSHiGG_04330 Haemophilus influenzae PittGG 16S ribosomal RNA methyltransferase RsmE YP_001292210.1 816687 D 374931 CDS YP_001292211.1 148827458 5227324 817424..817981 1 NC_009567.1 COG1678 Putative transcriptional regulator; hypothetical protein 817981 5227324 CGSHiGG_04335 Haemophilus influenzae PittGG hypothetical protein YP_001292211.1 817424 D 374931 CDS YP_001292212.1 148827459 5227325 817981..818400 1 NC_009567.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 818400 5227325 CGSHiGG_04340 Haemophilus influenzae PittGG Holliday junction resolvase-like protein YP_001292212.1 817981 D 374931 CDS YP_001292213.1 148827460 5227326 complement(818450..819358) 1 NC_009567.1 Required for efficient pilin antigenic variation; recombination associated protein 819358 rdgC 5227326 rdgC Haemophilus influenzae PittGG recombination associated protein YP_001292213.1 818450 R 374931 CDS YP_001292214.1 148827461 5227327 819424..820239 1 NC_009567.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 820239 5227327 CGSHiGG_04350 Haemophilus influenzae PittGG pyrroline-5-carboxylate reductase YP_001292214.1 819424 D 374931 CDS YP_001292215.1 148827462 5227328 820309..821406 1 NC_009567.1 putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; putative 3-phenylpropionic acid transporter 821406 5227328 CGSHiGG_04355 Haemophilus influenzae PittGG putative 3-phenylpropionic acid transporter YP_001292215.1 820309 D 374931 CDS YP_001292216.1 148827463 5227329 821437..822330 1 NC_009567.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 822330 xerD 5227329 xerD Haemophilus influenzae PittGG site-specific tyrosine recombinase XerD YP_001292216.1 821437 D 374931 CDS YP_001292217.1 148827464 5227330 822503..822790 1 NC_009567.1 COG1196 Chromosome segregation ATPases; hypothetical protein 822790 5227330 CGSHiGG_04365 Haemophilus influenzae PittGG hypothetical protein YP_001292217.1 822503 D 374931 CDS YP_001292218.1 148827465 5227331 complement(823856..824470) 1 NC_009567.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 824470 ruvA 5227331 ruvA Haemophilus influenzae PittGG Holliday junction DNA helicase RuvA YP_001292218.1 823856 R 374931 CDS YP_001292219.1 148827466 5227332 complement(824532..825104) 1 NC_009567.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 825104 ruvC 5227332 ruvC Haemophilus influenzae PittGG Holliday junction resolvase YP_001292219.1 824532 R 374931 CDS YP_001292220.1 148827467 5227333 complement(825151..825891) 1 NC_009567.1 COG0217 Uncharacterized conserved protein; hypothetical protein 825891 5227333 CGSHiGG_04390 Haemophilus influenzae PittGG hypothetical protein YP_001292220.1 825151 R 374931 CDS YP_001292221.1 148827468 5227334 complement(826051..826515) 1 NC_009567.1 converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 826515 ntpA 5227334 ntpA Haemophilus influenzae PittGG dATP pyrophosphohydrolase YP_001292221.1 826051 R 374931 CDS YP_001292222.1 148827469 5227335 complement(826549..828315) 1 NC_009567.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 828315 aspS 5227335 aspS Haemophilus influenzae PittGG aspartyl-tRNA synthetase YP_001292222.1 826549 R 374931 CDS YP_001292223.1 148827470 5227336 828534..829052 1 NC_009567.1 COG1755 Uncharacterized protein conserved in bacteria; hypothetical protein 829052 5227336 CGSHiGG_04405 Haemophilus influenzae PittGG hypothetical protein YP_001292223.1 828534 D 374931 CDS YP_001292224.1 148827471 5227337 829105..829830 1 NC_009567.1 COG0500 SAM-dependent methyltransferases; hypothetical protein 829830 5227337 CGSHiGG_04410 Haemophilus influenzae PittGG hypothetical protein YP_001292224.1 829105 D 374931 CDS YP_001292225.1 148827472 5227338 829904..830311 1 NC_009567.1 COG0346 Lactoylglutathione lyase and related lyases; lactoylglutathione lyase 830311 5227338 CGSHiGG_04415 Haemophilus influenzae PittGG lactoylglutathione lyase YP_001292225.1 829904 D 374931 CDS YP_001292226.1 148827473 5227339 830382..831071 1 NC_009567.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 831071 5227339 CGSHiGG_04420 Haemophilus influenzae PittGG ribonuclease T YP_001292226.1 830382 D 374931 CDS YP_001292227.1 148827474 5227340 831385..832737 1 NC_009567.1 COG2056 Predicted permease; hypothetical protein 832737 5227340 CGSHiGG_04425 Haemophilus influenzae PittGG hypothetical protein YP_001292227.1 831385 D 374931 CDS YP_001292228.1 148827475 5227341 832770..833357 1 NC_009567.1 COG3923 Primosomal replication protein N''; primosomal replication protein N 833357 5227341 CGSHiGG_04430 Haemophilus influenzae PittGG primosomal replication protein N YP_001292228.1 832770 D 374931 CDS YP_001292229.1 148827476 5227342 complement(833709..834275) 1 NC_009567.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 834275 5227342 CGSHiGG_04435 Haemophilus influenzae PittGG elongation factor P YP_001292229.1 833709 R 374931 CDS YP_001292230.1 148827477 5227343 835438..836724 1 NC_009567.1 opacity associated protein 836724 5227343 CGSHiGG_04450 Haemophilus influenzae PittGG opacity associated protein YP_001292230.1 835438 D 374931 CDS YP_001292231.1 148827478 5227344 836783..837187 1 NC_009567.1 COG3061 Cell envelope opacity-associated protein A; opacity associated protein OapB 837187 5227344 CGSHiGG_04455 Haemophilus influenzae PittGG opacity associated protein OapB YP_001292231.1 836783 D 374931 CDS YP_001292232.1 148827479 5227345 837190..837900 1 NC_009567.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 837900 recO 5227345 recO Haemophilus influenzae PittGG DNA repair protein RecO YP_001292232.1 837190 D 374931 CDS YP_001292233.1 148827480 5227346 837900..839216 1 NC_009567.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 839216 rumA 5227346 rumA Haemophilus influenzae PittGG 23S rRNA 5-methyluridine methyltransferase YP_001292233.1 837900 D 374931 CDS YP_001292234.1 148827481 5227347 839294..841525 1 NC_009567.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; GTP pyrophosphokinase 841525 5227347 CGSHiGG_04470 Haemophilus influenzae PittGG GTP pyrophosphokinase YP_001292234.1 839294 D 374931 CDS YP_001292235.1 148827482 5227348 841540..841896 1 NC_009567.1 COG0818 Diacylglycerol kinase; diacylglycerol kinase 841896 5227348 CGSHiGG_04475 Haemophilus influenzae PittGG diacylglycerol kinase YP_001292235.1 841540 D 374931 CDS YP_001292236.1 148827483 5227349 841979..842572 1 NC_009567.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 842572 mogA 5227349 mogA Haemophilus influenzae PittGG molybdenum cofactor biosynthesis protein MogA YP_001292236.1 841979 D 374931 CDS YP_001292237.1 148827484 5227350 842574..842912 1 NC_009567.1 COG0347 Nitrogen regulatory protein PII; nitrogen regulatory protein P-II 842912 5227350 CGSHiGG_04485 Haemophilus influenzae PittGG nitrogen regulatory protein P-II YP_001292237.1 842574 D 374931 CDS YP_001292238.1 148827485 5227351 842912..843958 1 NC_009567.1 COG0628 Predicted permease; hypothetical protein 843958 5227351 CGSHiGG_04490 Haemophilus influenzae PittGG hypothetical protein YP_001292238.1 842912 D 374931 CDS YP_001292239.1 148827486 5227352 846275..847015 1 NC_009567.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 847015 trmB 5227352 trmB Haemophilus influenzae PittGG tRNA (guanine-N(7)-)-methyltransferase YP_001292239.1 846275 D 374931 CDS YP_001292240.1 148827487 5227353 847100..847444 1 NC_009567.1 COG3171 Uncharacterized protein conserved in bacteria; hypothetical protein 847444 5227353 CGSHiGG_04510 Haemophilus influenzae PittGG hypothetical protein YP_001292240.1 847100 D 374931 CDS YP_001292241.1 148827488 5227354 847650..848093 1 NC_009567.1 COG1145 Ferredoxin; ferredoxin-type protein NapF 848093 5227354 CGSHiGG_04515 Haemophilus influenzae PittGG ferredoxin-type protein NapF YP_001292241.1 847650 D 374931 CDS YP_001292242.1 148827489 5227355 848174..848455 1 NC_009567.1 COG3062 Uncharacterized protein involved in formation of periplasmic nitrate reductase; hypothetical protein 848455 5227355 CGSHiGG_04520 Haemophilus influenzae PittGG hypothetical protein YP_001292242.1 848174 D 374931 CDS YP_001292243.1 148827490 5227356 851029..851868 1 NC_009567.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component 851868 napG 5227356 napG Haemophilus influenzae PittGG quinol dehydrogenase periplasmic component YP_001292243.1 851029 D 374931 CDS YP_001292244.1 148827491 5227357 851868..852731 1 NC_009567.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component 852731 napH 5227357 napH Haemophilus influenzae PittGG quinol dehydrogenase membrane component YP_001292244.1 851868 D 374931 CDS YP_001292245.1 148827492 5227358 852737..853180 1 NC_009567.1 hypothetical protein 853180 5227358 CGSHiGG_04545 Haemophilus influenzae PittGG hypothetical protein YP_001292245.1 852737 D 374931 CDS YP_001292246.1 148827493 5227359 853195..853797 1 NC_009567.1 hypothetical protein 853797 5227359 CGSHiGG_04550 Haemophilus influenzae PittGG hypothetical protein YP_001292246.1 853195 D 374931 CDS YP_001292247.1 148827494 5227360 complement(853956..854600) 1 NC_009567.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 854600 adk 5227360 adk Haemophilus influenzae PittGG adenylate kinase YP_001292247.1 853956 R 374931 CDS YP_001292248.1 148827495 5227361 complement(854685..855923) 1 NC_009567.1 hypothetical protein 855923 5227361 CGSHiGG_04560 Haemophilus influenzae PittGG hypothetical protein YP_001292248.1 854685 R 374931 CDS YP_001292249.1 148827496 5227362 complement(856104..857120) 1 NC_009567.1 UDP-glucose 4-epimerase 857120 5227362 CGSHiGG_04565 Haemophilus influenzae PittGG UDP-glucose 4-epimerase YP_001292249.1 856104 R 374931 CDS YP_001292250.1 148827497 5227363 complement(857293..858273) 1 NC_009567.1 hypothetical protein 858273 5227363 CGSHiGG_04570 Haemophilus influenzae PittGG hypothetical protein YP_001292250.1 857293 R 374931 CDS YP_001292251.1 148827498 5227364 858657..859379 1 NC_009567.1 hypothetical protein 859379 5227364 CGSHiGG_04575 Haemophilus influenzae PittGG hypothetical protein YP_001292251.1 858657 D 374931 CDS YP_001292252.1 148827499 5227365 860135..861079 1 NC_009567.1 hypothetical protein 861079 5227365 CGSHiGG_04590 Haemophilus influenzae PittGG hypothetical protein YP_001292252.1 860135 D 374931 CDS YP_001292253.1 148827500 5227366 861089..861736 1 NC_009567.1 hypothetical protein 861736 5227366 CGSHiGG_04595 Haemophilus influenzae PittGG hypothetical protein YP_001292253.1 861089 D 374931 CDS YP_001292254.1 148827501 5227367 complement(861854..862669) 1 NC_009567.1 hypothetical protein 862669 5227367 CGSHiGG_04600 Haemophilus influenzae PittGG hypothetical protein YP_001292254.1 861854 R 374931 CDS YP_001292255.1 148827502 5227368 complement(862662..863510) 1 NC_009567.1 hypothetical protein 863510 5227368 CGSHiGG_04605 Haemophilus influenzae PittGG hypothetical protein YP_001292255.1 862662 R 374931 CDS YP_001292256.1 148827503 5227369 complement(864435..865316) 1 NC_009567.1 hypothetical protein 865316 5227369 CGSHiGG_04620 Haemophilus influenzae PittGG hypothetical protein YP_001292256.1 864435 R 374931 CDS YP_001292257.1 148827504 5227370 complement(865682..866560) 1 NC_009567.1 hypothetical protein 866560 5227370 CGSHiGG_04625 Haemophilus influenzae PittGG hypothetical protein YP_001292257.1 865682 R 374931 CDS YP_001292258.1 148827505 5227371 868060..868599 1 NC_009567.1 hypothetical protein 868599 5227371 CGSHiGG_04640 Haemophilus influenzae PittGG hypothetical protein YP_001292258.1 868060 D 374931 CDS YP_001292259.1 148827506 5227372 868671..869582 1 NC_009567.1 hypothetical protein 869582 5227372 CGSHiGG_04645 Haemophilus influenzae PittGG hypothetical protein YP_001292259.1 868671 D 374931 CDS YP_001292260.1 148827507 5227373 869591..870697 1 NC_009567.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 870697 ispG 5227373 ispG Haemophilus influenzae PittGG 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_001292260.1 869591 D 374931 CDS YP_001292261.1 148827508 5227374 870707..871978 1 NC_009567.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 871978 hisS 5227374 hisS Haemophilus influenzae PittGG histidyl-tRNA synthetase YP_001292261.1 870707 D 374931 CDS YP_001292262.1 148827509 5227375 871996..872610 1 NC_009567.1 hypothetical protein 872610 5227375 CGSHiGG_04660 Haemophilus influenzae PittGG hypothetical protein YP_001292262.1 871996 D 374931 CDS YP_001292263.1 148827510 5227376 complement(872661..872855) 1 NC_009567.1 hypothetical protein 872855 5227376 CGSHiGG_04665 Haemophilus influenzae PittGG hypothetical protein YP_001292263.1 872661 R 374931 CDS YP_001292264.1 148827511 5227377 complement(872855..873196) 1 NC_009567.1 hypothetical protein 873196 5227377 CGSHiGG_04670 Haemophilus influenzae PittGG hypothetical protein YP_001292264.1 872855 R 374931 CDS YP_001292265.1 148827512 5227378 complement(873236..875095) 1 NC_009567.1 involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 875095 hscA 5227378 hscA Haemophilus influenzae PittGG chaperone protein HscA YP_001292265.1 873236 R 374931 CDS YP_001292266.1 148827513 5227379 complement(875114..875800) 1 NC_009567.1 hypothetical protein 875800 5227379 CGSHiGG_04680 Haemophilus influenzae PittGG hypothetical protein YP_001292266.1 875114 R 374931 CDS YP_001292267.1 148827514 5227380 complement(875851..876375) 1 NC_009567.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB 876375 hscB 5227380 hscB Haemophilus influenzae PittGG co-chaperone HscB YP_001292267.1 875851 R 374931 CDS YP_001292268.1 148827515 5227381 complement(876388..876711) 1 NC_009567.1 hypothetical protein 876711 5227381 CGSHiGG_04690 Haemophilus influenzae PittGG hypothetical protein YP_001292268.1 876388 R 374931 CDS YP_001292269.1 148827516 5227382 complement(876767..877147) 1 NC_009567.1 scaffold protein 877147 5227382 CGSHiGG_04695 Haemophilus influenzae PittGG scaffold protein YP_001292269.1 876767 R 374931 CDS YP_001292270.1 148827517 5227383 complement(877207..878421) 1 NC_009567.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 878421 5227383 CGSHiGG_04700 Haemophilus influenzae PittGG cysteine desulfurase YP_001292270.1 877207 R 374931 CDS YP_001292271.1 148827518 5227384 complement(878488..878940) 1 NC_009567.1 hypothetical protein 878940 5227384 CGSHiGG_04705 Haemophilus influenzae PittGG hypothetical protein YP_001292271.1 878488 R 374931 CDS YP_001292272.1 148827519 5227385 complement(878993..879718) 1 NC_009567.1 hypothetical protein 879718 5227385 CGSHiGG_04710 Haemophilus influenzae PittGG hypothetical protein YP_001292272.1 878993 R 374931 CDS YP_001292273.1 148827520 5227386 complement(880367..880825) 1 NC_009567.1 hypothetical protein 880825 5227386 CGSHiGG_04715 Haemophilus influenzae PittGG hypothetical protein YP_001292273.1 880367 R 374931 CDS YP_001292274.1 148827521 5227387 complement(880822..881421) 1 NC_009567.1 hypothetical protein 881421 5227387 CGSHiGG_04720 Haemophilus influenzae PittGG hypothetical protein YP_001292274.1 880822 R 374931 CDS YP_001292275.1 148827522 5227388 complement(883508..884122) 1 NC_009567.1 hypothetical protein 884122 5227388 CGSHiGG_04735 Haemophilus influenzae PittGG hypothetical protein YP_001292275.1 883508 R 374931 CDS YP_001292276.1 148827523 5227389 complement(884131..885567) 1 NC_009567.1 hypothetical protein 885567 5227389 CGSHiGG_04740 Haemophilus influenzae PittGG hypothetical protein YP_001292276.1 884131 R 374931 CDS YP_001292277.1 148827524 5227390 complement(885560..885925) 1 NC_009567.1 hypothetical protein 885925 5227390 CGSHiGG_04745 Haemophilus influenzae PittGG hypothetical protein YP_001292277.1 885560 R 374931 CDS YP_001292278.1 148827525 5227391 complement(885922..886593) 1 NC_009567.1 hypothetical protein 886593 5227391 CGSHiGG_04750 Haemophilus influenzae PittGG hypothetical protein YP_001292278.1 885922 R 374931 CDS YP_001292279.1 148827526 5227392 complement(886596..887552) 1 NC_009567.1 hypothetical protein 887552 5227392 CGSHiGG_04755 Haemophilus influenzae PittGG hypothetical protein YP_001292279.1 886596 R 374931 CDS YP_001292280.1 148827527 5227393 complement(887549..887863) 1 NC_009567.1 hypothetical protein 887863 5227393 CGSHiGG_04760 Haemophilus influenzae PittGG hypothetical protein YP_001292280.1 887549 R 374931 CDS YP_001292281.1 148827528 5227394 complement(887860..888441) 1 NC_009567.1 hypothetical protein 888441 5227394 CGSHiGG_04765 Haemophilus influenzae PittGG hypothetical protein YP_001292281.1 887860 R 374931 CDS YP_001292282.1 148827529 5227395 complement(888532..890862) 1 NC_009567.1 hypothetical protein 890862 5227395 CGSHiGG_04770 Haemophilus influenzae PittGG hypothetical protein YP_001292282.1 888532 R 374931 CDS YP_001292283.1 148827530 5227396 complement(890859..891011) 1 NC_009567.1 hypothetical protein 891011 5227396 CGSHiGG_04775 Haemophilus influenzae PittGG hypothetical protein YP_001292283.1 890859 R 374931 CDS YP_001292284.1 148827531 5227397 complement(891047..891529) 1 NC_009567.1 hypothetical protein 891529 5227397 CGSHiGG_04780 Haemophilus influenzae PittGG hypothetical protein YP_001292284.1 891047 R 374931 CDS YP_001292285.1 148827532 5227398 complement(891516..891953) 1 NC_009567.1 hypothetical protein 891953 5227398 CGSHiGG_04785 Haemophilus influenzae PittGG hypothetical protein YP_001292285.1 891516 R 374931 CDS YP_001292286.1 148827533 5227399 complement(891999..893072) 1 NC_009567.1 hypothetical protein 893072 5227399 CGSHiGG_04790 Haemophilus influenzae PittGG hypothetical protein YP_001292286.1 891999 R 374931 CDS YP_001292287.1 148827534 5227400 complement(893059..893568) 1 NC_009567.1 hypothetical protein 893568 5227400 CGSHiGG_04795 Haemophilus influenzae PittGG hypothetical protein YP_001292287.1 893059 R 374931 CDS YP_001292288.1 148827535 5227401 complement(893570..893929) 1 NC_009567.1 hypothetical protein 893929 5227401 CGSHiGG_04800 Haemophilus influenzae PittGG hypothetical protein YP_001292288.1 893570 R 374931 CDS YP_001292289.1 148827536 5227402 complement(893929..894387) 1 NC_009567.1 hypothetical protein 894387 5227402 CGSHiGG_04805 Haemophilus influenzae PittGG hypothetical protein YP_001292289.1 893929 R 374931 CDS YP_001292290.1 148827537 5227403 complement(894433..894729) 1 NC_009567.1 hypothetical protein 894729 5227403 CGSHiGG_04810 Haemophilus influenzae PittGG hypothetical protein YP_001292290.1 894433 R 374931 CDS YP_001292291.1 148827538 5227404 complement(894733..894921) 1 NC_009567.1 hypothetical protein 894921 5227404 CGSHiGG_04815 Haemophilus influenzae PittGG hypothetical protein YP_001292291.1 894733 R 374931 CDS YP_001292292.1 148827539 5227405 complement(894924..895871) 1 NC_009567.1 hypothetical protein 895871 5227405 CGSHiGG_04820 Haemophilus influenzae PittGG hypothetical protein YP_001292292.1 894924 R 374931 CDS YP_001292293.1 148827540 5227406 complement(895933..896352) 1 NC_009567.1 hypothetical protein 896352 5227406 CGSHiGG_04825 Haemophilus influenzae PittGG hypothetical protein YP_001292293.1 895933 R 374931 CDS YP_001292294.1 148827541 5227407 complement(896365..897438) 1 NC_009567.1 hypothetical protein 897438 5227407 CGSHiGG_04830 Haemophilus influenzae PittGG hypothetical protein YP_001292294.1 896365 R 374931 CDS YP_001292295.1 148827542 5227408 complement(897564..898781) 1 NC_009567.1 hypothetical protein 898781 5227408 CGSHiGG_04835 Haemophilus influenzae PittGG hypothetical protein YP_001292295.1 897564 R 374931 CDS YP_001292296.1 148827543 5227409 complement(898762..900078) 1 NC_009567.1 hypothetical protein 900078 5227409 CGSHiGG_04840 Haemophilus influenzae PittGG hypothetical protein YP_001292296.1 898762 R 374931 CDS YP_001292297.1 148827544 5227410 complement(900080..901429) 1 NC_009567.1 hypothetical protein 901429 5227410 CGSHiGG_04845 Haemophilus influenzae PittGG hypothetical protein YP_001292297.1 900080 R 374931 CDS YP_001292298.1 148827545 5227411 complement(901410..901778) 1 NC_009567.1 hypothetical protein 901778 5227411 CGSHiGG_04850 Haemophilus influenzae PittGG hypothetical protein YP_001292298.1 901410 R 374931 CDS YP_001292299.1 148827546 5227412 901836..902057 1 NC_009567.1 hypothetical protein 902057 5227412 CGSHiGG_04855 Haemophilus influenzae PittGG hypothetical protein YP_001292299.1 901836 D 374931 CDS YP_001292300.1 148827547 5227413 complement(902054..903409) 1 NC_009567.1 hypothetical protein 903409 5227413 CGSHiGG_04860 Haemophilus influenzae PittGG hypothetical protein YP_001292300.1 902054 R 374931 CDS YP_001292301.1 148827548 5227414 complement(903421..903651) 1 NC_009567.1 hypothetical protein 903651 5227414 CGSHiGG_04865 Haemophilus influenzae PittGG hypothetical protein YP_001292301.1 903421 R 374931 CDS YP_001292302.1 148827549 5227415 complement(903626..904015) 1 NC_009567.1 hypothetical protein 904015 5227415 CGSHiGG_04870 Haemophilus influenzae PittGG hypothetical protein YP_001292302.1 903626 R 374931 CDS YP_001292303.1 148827550 5227416 complement(904012..904416) 1 NC_009567.1 hypothetical protein 904416 5227416 CGSHiGG_04875 Haemophilus influenzae PittGG hypothetical protein YP_001292303.1 904012 R 374931 CDS YP_001292304.1 148827551 5227417 complement(904403..904570) 1 NC_009567.1 hypothetical protein 904570 5227417 CGSHiGG_04880 Haemophilus influenzae PittGG hypothetical protein YP_001292304.1 904403 R 374931 CDS YP_001292305.1 148827552 5227418 complement(904922..905692) 1 NC_009567.1 hypothetical protein 905692 5227418 CGSHiGG_04885 Haemophilus influenzae PittGG hypothetical protein YP_001292305.1 904922 R 374931 CDS YP_001292306.1 148827553 5227419 905817..906023 1 NC_009567.1 hypothetical protein 906023 5227419 CGSHiGG_04890 Haemophilus influenzae PittGG hypothetical protein YP_001292306.1 905817 D 374931 CDS YP_001292307.1 148827554 5227420 906565..906798 1 NC_009567.1 hypothetical protein 906798 5227420 CGSHiGG_04895 Haemophilus influenzae PittGG hypothetical protein YP_001292307.1 906565 D 374931 CDS YP_001292308.1 148827555 5227421 906800..907582 1 NC_009567.1 hypothetical protein 907582 5227421 CGSHiGG_04900 Haemophilus influenzae PittGG hypothetical protein YP_001292308.1 906800 D 374931 CDS YP_001292309.1 148827556 5227422 908200..908424 1 NC_009567.1 hypothetical protein 908424 5227422 CGSHiGG_04915 Haemophilus influenzae PittGG hypothetical protein YP_001292309.1 908200 D 374931 CDS YP_001292310.1 148827557 5227423 908461..908877 1 NC_009567.1 hypothetical protein 908877 5227423 CGSHiGG_04920 Haemophilus influenzae PittGG hypothetical protein YP_001292310.1 908461 D 374931 CDS YP_001292311.1 148827558 5227424 908878..908970 1 NC_009567.1 hypothetical protein 908970 5227424 CGSHiGG_04925 Haemophilus influenzae PittGG hypothetical protein YP_001292311.1 908878 D 374931 CDS YP_001292312.1 148827559 5227425 908970..909581 1 NC_009567.1 hypothetical protein 909581 5227425 CGSHiGG_04930 Haemophilus influenzae PittGG hypothetical protein YP_001292312.1 908970 D 374931 CDS YP_001292313.1 148827560 5227426 909560..909925 1 NC_009567.1 hypothetical protein 909925 5227426 CGSHiGG_04935 Haemophilus influenzae PittGG hypothetical protein YP_001292313.1 909560 D 374931 CDS YP_001292314.1 148827561 5227427 910048..910848 1 NC_009567.1 hypothetical protein 910848 5227427 CGSHiGG_04940 Haemophilus influenzae PittGG hypothetical protein YP_001292314.1 910048 D 374931 CDS YP_001292315.1 148827562 5227428 910859..912007 1 NC_009567.1 hypothetical protein 912007 5227428 CGSHiGG_04945 Haemophilus influenzae PittGG hypothetical protein YP_001292315.1 910859 D 374931 CDS YP_001292316.1 148827563 5227429 912157..912342 1 NC_009567.1 hypothetical protein 912342 5227429 CGSHiGG_04950 Haemophilus influenzae PittGG hypothetical protein YP_001292316.1 912157 D 374931 CDS YP_001292317.1 148827564 5226336 912732..913043 1 NC_009567.1 hypothetical protein 913043 5226336 CGSHiGG_04955 Haemophilus influenzae PittGG hypothetical protein YP_001292317.1 912732 D 374931 CDS YP_001292318.1 148827565 5226337 913163..913414 1 NC_009567.1 hypothetical protein 913414 5226337 CGSHiGG_04960 Haemophilus influenzae PittGG hypothetical protein YP_001292318.1 913163 D 374931 CDS YP_001292319.1 148827566 5226338 913404..914435 1 NC_009567.1 hypothetical protein 914435 5226338 CGSHiGG_04965 Haemophilus influenzae PittGG hypothetical protein YP_001292319.1 913404 D 374931 CDS YP_001292320.1 148827567 5226339 914526..915257 1 NC_009567.1 hypothetical protein 915257 5226339 CGSHiGG_04970 Haemophilus influenzae PittGG hypothetical protein YP_001292320.1 914526 D 374931 CDS YP_001292321.1 148827568 5226340 915278..915622 1 NC_009567.1 hypothetical protein 915622 5226340 CGSHiGG_04975 Haemophilus influenzae PittGG hypothetical protein YP_001292321.1 915278 D 374931 CDS YP_001292322.1 148827569 5226341 915619..915912 1 NC_009567.1 hypothetical protein 915912 5226341 CGSHiGG_04980 Haemophilus influenzae PittGG hypothetical protein YP_001292322.1 915619 D 374931 CDS YP_001292323.1 148827570 5226342 915925..916845 1 NC_009567.1 hypothetical protein 916845 5226342 CGSHiGG_04985 Haemophilus influenzae PittGG hypothetical protein YP_001292323.1 915925 D 374931 CDS YP_001292324.1 148827571 5226343 916820..917470 1 NC_009567.1 hypothetical protein 917470 5226343 CGSHiGG_04990 Haemophilus influenzae PittGG hypothetical protein YP_001292324.1 916820 D 374931 CDS YP_001292325.1 148827572 5226344 917470..917904 1 NC_009567.1 hypothetical protein 917904 5226344 CGSHiGG_04995 Haemophilus influenzae PittGG hypothetical protein YP_001292325.1 917470 D 374931 CDS YP_001292326.1 148827573 5226345 917967..918746 1 NC_009567.1 hypothetical protein 918746 5226345 CGSHiGG_05000 Haemophilus influenzae PittGG hypothetical protein YP_001292326.1 917967 D 374931 CDS YP_001292327.1 148827574 5226346 918852..919763 1 NC_009567.1 Required for efficient pilin antigenic variation; recombination associated protein 919763 rdgC 5226346 rdgC Haemophilus influenzae PittGG recombination associated protein YP_001292327.1 918852 D 374931 CDS YP_001292328.1 148827575 5226347 919760..920005 1 NC_009567.1 hypothetical protein 920005 5226347 CGSHiGG_05010 Haemophilus influenzae PittGG hypothetical protein YP_001292328.1 919760 D 374931 CDS YP_001292329.1 148827576 5226348 920002..920361 1 NC_009567.1 hypothetical protein 920361 5226348 CGSHiGG_05015 Haemophilus influenzae PittGG hypothetical protein YP_001292329.1 920002 D 374931 CDS YP_001292330.1 148827577 5226349 920369..921643 1 NC_009567.1 hypothetical protein 921643 5226349 CGSHiGG_05020 Haemophilus influenzae PittGG hypothetical protein YP_001292330.1 920369 D 374931 CDS YP_001292331.1 148827578 5226350 921694..922215 1 NC_009567.1 hypothetical protein 922215 5226350 CGSHiGG_05025 Haemophilus influenzae PittGG hypothetical protein YP_001292331.1 921694 D 374931 CDS YP_001292332.1 148827579 5226351 922269..922346 1 NC_009567.1 hypothetical protein 922346 5226351 CGSHiGG_05030 Haemophilus influenzae PittGG hypothetical protein YP_001292332.1 922269 D 374931 CDS YP_001292333.1 148827580 5226352 922350..922766 1 NC_009567.1 hypothetical protein 922766 5226352 CGSHiGG_05035 Haemophilus influenzae PittGG hypothetical protein YP_001292333.1 922350 D 374931 CDS YP_001292334.1 148827581 5226353 922838..923371 1 NC_009567.1 hypothetical protein 923371 5226353 CGSHiGG_05040 Haemophilus influenzae PittGG hypothetical protein YP_001292334.1 922838 D 374931 CDS YP_001292335.1 148827582 5226354 923361..923684 1 NC_009567.1 hypothetical protein 923684 5226354 CGSHiGG_05045 Haemophilus influenzae PittGG hypothetical protein YP_001292335.1 923361 D 374931 CDS YP_001292336.1 148827583 5226355 923677..924021 1 NC_009567.1 hypothetical protein 924021 5226355 CGSHiGG_05050 Haemophilus influenzae PittGG hypothetical protein YP_001292336.1 923677 D 374931 CDS YP_001292337.1 148827584 5226356 924073..924387 1 NC_009567.1 hypothetical protein 924387 5226356 CGSHiGG_05055 Haemophilus influenzae PittGG hypothetical protein YP_001292337.1 924073 D 374931 CDS YP_001292338.1 148827585 5226357 924429..925310 1 NC_009567.1 hypothetical protein 925310 5226357 CGSHiGG_05060 Haemophilus influenzae PittGG hypothetical protein YP_001292338.1 924429 D 374931 CDS YP_001292339.1 148827586 5226358 complement(925744..926205) 1 NC_009567.1 hypothetical protein 926205 5226358 CGSHiGG_05065 Haemophilus influenzae PittGG hypothetical protein YP_001292339.1 925744 R 374931 CDS YP_001292340.1 148827587 5226359 complement(926229..927512) 1 NC_009567.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 927512 tolB 5226359 tolB Haemophilus influenzae PittGG translocation protein TolB YP_001292340.1 926229 R 374931 CDS YP_001292341.1 148827588 5226360 complement(927554..928786) 1 NC_009567.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 928786 tolA 5226360 tolA Haemophilus influenzae PittGG cell envelope integrity inner membrane protein TolA YP_001292341.1 927554 R 374931 CDS YP_001292342.1 148827589 5226361 complement(928802..929221) 1 NC_009567.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 929221 5226361 CGSHiGG_05080 Haemophilus influenzae PittGG colicin uptake protein TolR YP_001292342.1 928802 R 374931 CDS YP_001292343.1 148827590 5226362 complement(929996..930406) 1 NC_009567.1 hypothetical protein 930406 5226362 CGSHiGG_05095 Haemophilus influenzae PittGG hypothetical protein YP_001292343.1 929996 R 374931 CDS YP_001292344.1 148827591 5226363 932669..933379 1 NC_009567.1 hypothetical protein 933379 5226363 CGSHiGG_05110 Haemophilus influenzae PittGG hypothetical protein YP_001292344.1 932669 D 374931 CDS YP_001292345.1 148827592 5226364 933404..933955 1 NC_009567.1 hypothetical protein 933955 5226364 CGSHiGG_05115 Haemophilus influenzae PittGG hypothetical protein YP_001292345.1 933404 D 374931 CDS YP_001292346.1 148827593 5226365 935686..936891 1 NC_009567.1 COG0349 Ribonuclease D; ribonuclease D 936891 5226365 CGSHiGG_05130 Haemophilus influenzae PittGG ribonuclease D YP_001292346.1 935686 D 374931 CDS YP_001292347.1 148827594 5226366 complement(936928..938820) 1 NC_009567.1 COG1835 Predicted acyltransferases; long-chain-fatty-acid--CoA ligase 938820 5226366 CGSHiGG_05135 Haemophilus influenzae PittGG long-chain-fatty-acid--CoA ligase YP_001292347.1 936928 R 374931 CDS YP_001292348.1 148827595 5226367 complement(938894..939985) 1 NC_009567.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 939985 5226367 CGSHiGG_05140 Haemophilus influenzae PittGG GTP-dependent nucleic acid-binding protein EngD YP_001292348.1 938894 R 374931 CDS YP_001292349.1 148827596 5226368 complement(940033..940617) 1 NC_009567.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 940617 5226368 CGSHiGG_05145 Haemophilus influenzae PittGG peptidyl-tRNA hydrolase YP_001292349.1 940033 R 374931 CDS YP_001292350.1 148827597 5226369 940800..941108 1 NC_009567.1 COG2914 Uncharacterized protein conserved in bacteria; hypothetical protein 941108 5226369 CGSHiGG_05150 Haemophilus influenzae PittGG hypothetical protein YP_001292350.1 940800 D 374931 CDS YP_001292351.1 148827598 5226370 941111..942325 1 NC_009567.1 COG2850 Uncharacterized conserved protein; hypothetical protein 942325 5226370 CGSHiGG_05155 Haemophilus influenzae PittGG hypothetical protein YP_001292351.1 941111 D 374931 CDS YP_001292352.1 148827599 5226371 942318..943646 1 NC_009567.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 943646 xseA 5226371 xseA Haemophilus influenzae PittGG exodeoxyribonuclease VII large subunit YP_001292352.1 942318 D 374931 CDS YP_001292353.1 148827600 5226372 943844..944476 1 NC_009567.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; exodeoxyribonuclease VII large subunit 944476 xseA 5226372 xseA Haemophilus influenzae PittGG exodeoxyribonuclease VII large subunit YP_001292353.1 943844 D 374931 CDS YP_001292354.1 148827601 5226373 944485..945309 1 NC_009567.1 COG1409 Predicted phosphohydrolases; cyclic 3',5'-adenosine monophosphate phosphodiesterase 945309 5226373 CGSHiGG_05170 Haemophilus influenzae PittGG cyclic 3',5'-adenosine monophosphate phosphodiesterase YP_001292354.1 944485 D 374931 CDS YP_001292355.1 148827602 5226374 complement(945407..945694) 1 NC_009567.1 COG3691 Uncharacterized protein conserved in bacteria; hypothetical protein 945694 5226374 CGSHiGG_05175 Haemophilus influenzae PittGG hypothetical protein YP_001292355.1 945407 R 374931 CDS YP_001292356.1 148827603 5226375 945901..947274 1 NC_009567.1 COG2067 Long-chain fatty acid transport protein; long-chain fatty acid transport protein 947274 5226375 CGSHiGG_05180 Haemophilus influenzae PittGG long-chain fatty acid transport protein YP_001292356.1 945901 D 374931 CDS YP_001292357.1 148827604 5226376 947348..947887 1 NC_009567.1 COG0350 Methylated DNA-protein cysteine methyltransferase; cyclic 3',5'-adenosine monophosphate phosphodiesterase 947887 5226376 CGSHiGG_05185 Haemophilus influenzae PittGG cyclic 3',5'-adenosine monophosphate phosphodiesterase YP_001292357.1 947348 D 374931 CDS YP_001292358.1 148827605 5226377 947884..948555 1 NC_009567.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 948555 5226377 CGSHiGG_05190 Haemophilus influenzae PittGG DNA mismatch repair protein YP_001292358.1 947884 D 374931 CDS YP_001292359.1 148827606 5226378 complement(948563..949855) 1 NC_009567.1 COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control; cell cycle protein 949855 5226378 CGSHiGG_05195 Haemophilus influenzae PittGG cell cycle protein YP_001292359.1 948563 R 374931 CDS YP_001292360.1 148827607 5226379 complement(949855..949959) 1 NC_009567.1 COG2240 Pyridoxal/pyridoxine/pyridoxamine kinase; DNA mismatch repair protein 949959 5226379 CGSHiGG_05200 Haemophilus influenzae PittGG DNA mismatch repair protein YP_001292360.1 949855 R 374931 CDS YP_001292361.1 148827608 5226380 complement(951067..951852) 1 NC_009567.1 COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; high-affinity zinc uptake system membrane protein ZnuB 951852 5226380 CGSHiGG_05215 Haemophilus influenzae PittGG high-affinity zinc uptake system membrane protein ZnuB YP_001292361.1 951067 R 374931 CDS YP_001292362.1 148827609 5226381 complement(951852..952658) 1 NC_009567.1 COG1121 ABC-type Mn/Zn transport systems, ATPase component; ABC transporter ATP-binding protein 952658 5226381 CGSHiGG_05220 Haemophilus influenzae PittGG ABC transporter ATP-binding protein YP_001292362.1 951852 R 374931 CDS YP_001292363.1 148827610 5226382 954374..955330 1 NC_009567.1 COG3283 Transcriptional regulator of aromatic amino acids metabolism; transcriptional regulatory protein TyrR 955330 5226382 CGSHiGG_05235 Haemophilus influenzae PittGG transcriptional regulatory protein TyrR YP_001292363.1 954374 D 374931 CDS YP_001292364.1 148827611 5226383 complement(955426..955701) 1 NC_009567.1 Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 955701 hfq 5226383 hfq Haemophilus influenzae PittGG RNA-binding protein Hfq YP_001292364.1 955426 R 374931 CDS YP_001292365.1 148827612 5226384 complement(955792..956760) 1 NC_009567.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 956760 5226384 CGSHiGG_05245 Haemophilus influenzae PittGG 23S rRNA pseudouridylate synthase C YP_001292365.1 955792 R 374931 CDS YP_001292366.1 148827613 5226385 957181..959988 1 NC_009567.1 ribonuclease E 959988 5226385 CGSHiGG_05250 Haemophilus influenzae PittGG ribonuclease E YP_001292366.1 957181 D 374931 CDS YP_001292367.1 148827614 5226386 960142..960378 1 NC_009567.1 COG1530 Ribonucleases G and E; 23S rRNA pseudouridylate synthase C 960378 5226386 CGSHiGG_05255 Haemophilus influenzae PittGG 23S rRNA pseudouridylate synthase C YP_001292367.1 960142 D 374931 CDS YP_001292368.1 148827615 5226387 960708..961499 1 NC_009567.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 961499 5226387 CGSHiGG_05260 Haemophilus influenzae PittGG hydroxyethylthiazole kinase YP_001292368.1 960708 D 374931 CDS YP_001292369.1 148827616 5226388 962311..962991 1 NC_009567.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 962991 thiE 5226388 thiE Haemophilus influenzae PittGG thiamine-phosphate pyrophosphorylase YP_001292369.1 962311 D 374931 CDS YP_001292370.1 148827617 5226389 complement(964290..964391) 1 NC_009567.1 COG0477 Permeases of the major facilitator superfamily; hypothetical protein 964391 5226389 CGSHiGG_05290 Haemophilus influenzae PittGG hypothetical protein YP_001292370.1 964290 R 374931 CDS YP_001292371.1 148827618 5226390 965974..966273 1 NC_009567.1 COG4453 Uncharacterized protein conserved in bacteria; hypothetical protein 966273 5226390 CGSHiGG_05305 Haemophilus influenzae PittGG hypothetical protein YP_001292371.1 965974 D 374931 CDS YP_001292372.1 148827619 5226391 966263..966781 1 NC_009567.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; histone acetyltransferase 966781 5226391 CGSHiGG_05310 Haemophilus influenzae PittGG histone acetyltransferase YP_001292372.1 966263 D 374931 CDS YP_001292373.1 148827620 5226392 complement(966927..967529) 1 NC_009567.1 COG5295 Autotransporter adhesin; thiamine-phosphate pyrophosphorylase 967529 thiE 5226392 thiE Haemophilus influenzae PittGG thiamine-phosphate pyrophosphorylase YP_001292373.1 966927 R 374931 CDS YP_001292374.1 148827621 5226393 complement(967717..969036) 1 NC_009567.1 facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 969036 5226393 CGSHiGG_05320 Haemophilus influenzae PittGG ATP-dependent RNA helicase SrmB YP_001292374.1 967717 R 374931 CDS YP_001292375.1 148827622 5226394 969106..969804 1 NC_009567.1 COG4123 Predicted O-methyltransferase; hypothetical protein 969804 5226394 CGSHiGG_05325 Haemophilus influenzae PittGG hypothetical protein YP_001292375.1 969106 D 374931 CDS YP_001292376.1 148827623 5226395 complement(969836..970951) 1 NC_009567.1 COG0566 rRNA methylases; ATP-dependent RNA helicase SrmB 970951 5226395 CGSHiGG_05330 Haemophilus influenzae PittGG ATP-dependent RNA helicase SrmB YP_001292376.1 969836 R 374931 CDS YP_001292377.1 148827624 5226396 971037..972404 1 NC_009567.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 972404 pssA 5226396 pssA Haemophilus influenzae PittGG phosphatidylserine synthase YP_001292377.1 971037 D 374931 CDS YP_001292378.1 148827625 5226397 complement(972449..973174) 1 NC_009567.1 Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 973174 5226397 CGSHiGG_05340 Haemophilus influenzae PittGG fatty acid metabolism regulator YP_001292378.1 972449 R 374931 CDS YP_001292379.1 148827626 5226398 974852..975385 1 NC_009567.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 975385 5226398 CGSHiGG_05355 Haemophilus influenzae PittGG disulfide bond formation protein B YP_001292379.1 974852 D 374931 CDS YP_001292380.1 148827627 5226399 complement(977385..977657) 1 NC_009567.1 COG0776 Bacterial nucleoid DNA-binding protein; DNA-binding protein HU 977657 5226399 CGSHiGG_05370 Haemophilus influenzae PittGG DNA-binding protein HU YP_001292380.1 977385 R 374931 CDS YP_001292381.1 148827628 5226400 complement(977797..978387) 1 NC_009567.1 COG3068 Uncharacterized protein conserved in bacteria; hypothetical protein 978387 5226400 CGSHiGG_05375 Haemophilus influenzae PittGG hypothetical protein YP_001292381.1 977797 R 374931 CDS YP_001292382.1 148827629 5226401 complement(978423..979217) 1 NC_009567.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 979217 nudC 5226401 nudC Haemophilus influenzae PittGG NADH pyrophosphatase YP_001292382.1 978423 R 374931 CDS YP_001292383.1 148827630 5226402 complement(979284..979880) 1 NC_009567.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; putative DNA uptake protein 979880 5226402 CGSHiGG_05385 Haemophilus influenzae PittGG putative DNA uptake protein YP_001292383.1 979284 R 374931 CDS YP_001292384.1 148827631 5226403 complement(979956..980642) 1 NC_009567.1 COG1040 Predicted amidophosphoribosyltransferases; competence protein F 980642 5226403 CGSHiGG_05390 Haemophilus influenzae PittGG competence protein F YP_001292384.1 979956 R 374931 CDS YP_001292385.1 148827632 5226404 complement(980655..981992) 1 NC_009567.1 competence protein E 981992 5226404 CGSHiGG_05395 Haemophilus influenzae PittGG competence protein E YP_001292385.1 980655 R 374931 CDS YP_001292386.1 148827633 5226405 complement(982002..982415) 1 NC_009567.1 competence protein D 982415 5226405 CGSHiGG_05400 Haemophilus influenzae PittGG competence protein D YP_001292386.1 982002 R 374931 CDS YP_001292387.1 148827634 5226406 complement(982412..982933) 1 NC_009567.1 competence protein C 982933 5226406 CGSHiGG_05405 Haemophilus influenzae PittGG competence protein C YP_001292387.1 982412 R 374931 CDS YP_001292388.1 148827635 5226407 complement(982930..983436) 1 NC_009567.1 competence protein B 983436 5226407 CGSHiGG_05410 Haemophilus influenzae PittGG competence protein B YP_001292388.1 982930 R 374931 CDS YP_001292389.1 148827636 5226408 complement(983437..984234) 1 NC_009567.1 COG4796 Type II secretory pathway, component HofQ; competence protein A 984234 5226408 CGSHiGG_05415 Haemophilus influenzae PittGG competence protein A YP_001292389.1 983437 R 374931 CDS YP_001292390.1 148827637 5226409 984333..986927 1 NC_009567.1 COG5009 Membrane carboxypeptidase/penicillin-binding protein; penicillin-binding protein 1A 986927 5226409 CGSHiGG_05420 Haemophilus influenzae PittGG penicillin-binding protein 1A YP_001292390.1 984333 D 374931 CDS YP_001292391.1 148827638 5226410 987997..988326 1 NC_009567.1 COG0718 Uncharacterized protein conserved in bacteria; hypothetical protein 988326 5226410 CGSHiGG_05435 Haemophilus influenzae PittGG hypothetical protein YP_001292391.1 987997 D 374931 CDS YP_001292392.1 148827639 5226411 988384..988986 1 NC_009567.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 988986 recR 5226411 recR Haemophilus influenzae PittGG recombination protein RecR YP_001292392.1 988384 D 374931 CDS YP_001292393.1 148827640 5226412 989002..990957 1 NC_009567.1 decatenates replicating daughter chromosomes; DNA topoisomerase III 990957 5226412 CGSHiGG_05445 Haemophilus influenzae PittGG DNA topoisomerase III YP_001292393.1 989002 D 374931 CDS YP_001292394.1 148827641 5226413 991066..991407 1 NC_009567.1 COG1314 Preprotein translocase subunit SecG; preprotein translocase subunit SecG 991407 secG 5226413 secG Haemophilus influenzae PittGG preprotein translocase subunit SecG YP_001292394.1 991066 D 374931 CDS YP_001292395.1 148827642 5226414 complement(991952..993622) 1 NC_009567.1 COG3925 N-terminal domain of the phosphotransferase system fructose-specific component IIB; preprotein translocase subunit SecG 993622 secG 5226414 secG Haemophilus influenzae PittGG preprotein translocase subunit SecG YP_001292395.1 991952 R 374931 CDS YP_001292396.1 148827643 5226415 complement(993624..994565) 1 NC_009567.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase 994565 fruK 5226415 fruK Haemophilus influenzae PittGG 1-phosphofructokinase YP_001292396.1 993624 R 374931 CDS YP_001292397.1 148827644 5226416 complement(994567..996066) 1 NC_009567.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein 996066 5226416 CGSHiGG_05465 Haemophilus influenzae PittGG bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein YP_001292397.1 994567 R 374931 CDS YP_001292398.1 148827645 5226417 complement(996138..996668) 1 NC_009567.1 COG4668 Mannitol/fructose-specific phosphotransferase system, IIA domain; hypothetical protein 996668 5226417 CGSHiGG_05470 Haemophilus influenzae PittGG hypothetical protein YP_001292398.1 996138 R 374931 CDS YP_001292399.1 148827646 5226418 complement(996761..997039) 1 NC_009567.1 virulence-associated protein D 997039 5226418 CGSHiGG_05475 Haemophilus influenzae PittGG virulence-associated protein D YP_001292399.1 996761 R 374931 CDS YP_001292400.1 148827647 5226419 complement(997048..997239) 1 NC_009567.1 COG3309 Uncharacterized virulence-associated protein D; hypothetical protein 997239 5226419 CGSHiGG_05480 Haemophilus influenzae PittGG hypothetical protein YP_001292400.1 997048 R 374931 CDS YP_001292401.1 148827648 5226420 complement(998659..999183) 1 NC_009567.1 COG1253 Hemolysins and related proteins containing CBS domains; hypothetical protein 999183 5226420 CGSHiGG_05495 Haemophilus influenzae PittGG hypothetical protein YP_001292401.1 998659 R 374931 CDS YP_001292402.1 148827649 5226421 complement(999210..999992) 1 NC_009567.1 COG0084 Mg-dependent DNase; fused fructose-specific PTS enzymes: IIA component/HPr component 999992 5226421 CGSHiGG_05500 Haemophilus influenzae PittGG fused fructose-specific PTS enzymes: IIA component/HPr component YP_001292402.1 999210 R 374931 CDS YP_001292403.1 148827650 5226422 complement(1000031..1001011) 1 NC_009567.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1001011 5226422 CGSHiGG_05505 Haemophilus influenzae PittGG DNA polymerase III subunit delta' YP_001292403.1 1000031 R 374931 CDS YP_001292404.1 148827651 5226423 1001211..1001315 1 NC_009567.1 COG0470 ATPase involved in DNA replication; hypothetical protein 1001315 5226423 CGSHiGG_05510 Haemophilus influenzae PittGG hypothetical protein YP_001292404.1 1001211 D 374931 CDS YP_001292405.1 148827652 5226424 1001351..1003522 1 NC_009567.1 COG3468 Type V secretory pathway, adhesin AidA; DNA polymerase III subunit delta' 1003522 5226424 CGSHiGG_05515 Haemophilus influenzae PittGG DNA polymerase III subunit delta' YP_001292405.1 1001351 D 374931 CDS YP_001292406.1 148827653 5226425 complement(1003587..1004219) 1 NC_009567.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1004219 tmk 5226425 tmk Haemophilus influenzae PittGG thymidylate kinase YP_001292406.1 1003587 R 374931 CDS YP_001292407.1 148827654 5226426 complement(1004236..1005279) 1 NC_009567.1 COG1559 Predicted periplasmic solute-binding protein; periplasmic solute-binding protein 1005279 5226426 CGSHiGG_05525 Haemophilus influenzae PittGG periplasmic solute-binding protein YP_001292407.1 1004236 R 374931 CDS YP_001292408.1 148827655 5226427 complement(1005351..1006286) 1 NC_009567.1 COG0760 Parvulin-like peptidyl-prolyl isomerase; thymidylate kinase 1006286 tdk 5226427 tdk Haemophilus influenzae PittGG thymidylate kinase YP_001292408.1 1005351 R 374931 CDS YP_001292409.1 148827656 5226428 complement(1006363..1006902) 1 NC_009567.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase 1006902 5226428 CGSHiGG_05535 Haemophilus influenzae PittGG bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase YP_001292409.1 1006363 R 374931 CDS YP_001292410.1 148827657 5226429 1007034..1007825 1 NC_009567.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase 1007825 mazG 5226429 mazG Haemophilus influenzae PittGG nucleoside triphosphate pyrophosphohydrolase YP_001292410.1 1007034 D 374931 CDS YP_001292411.1 148827658 5226430 complement(1007874..1008749) 1 NC_009567.1 COG2990 Uncharacterized protein conserved in bacteria; hypothetical protein 1008749 5226430 CGSHiGG_05545 Haemophilus influenzae PittGG hypothetical protein YP_001292411.1 1007874 R 374931 CDS YP_001292412.1 148827659 5226431 1008943..1011354 1 NC_009567.1 COG0466 ATP-dependent Lon protease, bacterial type; nucleoside triphosphate pyrophosphohydrolase 1011354 mazG 5226431 mazG Haemophilus influenzae PittGG nucleoside triphosphate pyrophosphohydrolase YP_001292412.1 1008943 D 374931 CDS YP_001292413.1 148827660 5226432 1011470..1012621 1 NC_009567.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 1012621 5226432 CGSHiGG_05555 Haemophilus influenzae PittGG coproporphyrinogen III oxidase YP_001292413.1 1011470 D 374931 CDS YP_001292414.1 148827661 5226433 1012754..1013413 1 NC_009567.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 1013413 5226433 CGSHiGG_05560 Haemophilus influenzae PittGG ribose-5-phosphate isomerase A YP_001292414.1 1012754 D 374931 CDS YP_001292415.1 148827662 5226434 1013443..1014675 1 NC_009567.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 1014675 5226434 CGSHiGG_05565 Haemophilus influenzae PittGG D-3-phosphoglycerate dehydrogenase YP_001292415.1 1013443 D 374931 CDS YP_001292416.1 148827663 5226435 complement(1014718..1015560) 1 NC_009567.1 COG0354 Predicted aminomethyltransferase related to GcvT; D-3-phosphoglycerate dehydrogenase 1015560 5226435 CGSHiGG_05570 Haemophilus influenzae PittGG D-3-phosphoglycerate dehydrogenase YP_001292416.1 1014718 R 374931 CDS YP_001292417.1 148827664 5226436 complement(1015570..1016433) 1 NC_009567.1 hypothetical protein 1016433 5226436 CGSHiGG_05575 Haemophilus influenzae PittGG hypothetical protein YP_001292417.1 1015570 R 374931 CDS YP_001292418.1 148827665 5226437 complement(1016452..1016718) 1 NC_009567.1 COG1561 Uncharacterized stress-induced protein; hypothetical protein 1016718 5226437 CGSHiGG_05580 Haemophilus influenzae PittGG hypothetical protein YP_001292418.1 1016452 R 374931 CDS YP_001292419.1 148827666 5226438 1016881..1017792 1 NC_009567.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 1017792 hisG 5226438 hisG Haemophilus influenzae PittGG ATP phosphoribosyltransferase YP_001292419.1 1016881 D 374931 CDS YP_001292420.1 148827667 5226439 1017886..1019169 1 NC_009567.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 1019169 hisD 5226439 hisD Haemophilus influenzae PittGG histidinol dehydrogenase YP_001292420.1 1017886 D 374931 CDS YP_001292421.1 148827668 5226440 1019283..1020341 1 NC_009567.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 1020341 5226440 CGSHiGG_05595 Haemophilus influenzae PittGG histidinol-phosphate aminotransferase YP_001292421.1 1019283 D 374931 CDS YP_001292422.1 148827669 5226441 1020453..1021541 1 NC_009567.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 1021541 5226441 CGSHiGG_05600 Haemophilus influenzae PittGG imidazole glycerol-phosphate dehydratase/histidinol phosphatase YP_001292422.1 1020453 D 374931 CDS YP_001292423.1 148827670 5226442 1021607..1022206 1 NC_009567.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 1022206 hisH 5226442 hisH Haemophilus influenzae PittGG imidazole glycerol phosphate synthase subunit HisH YP_001292423.1 1021607 D 374931 CDS YP_001292424.1 148827671 5226443 1022242..1022991 1 NC_009567.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 1022991 5226443 CGSHiGG_05610 Haemophilus influenzae PittGG 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase YP_001292424.1 1022242 D 374931 CDS YP_001292425.1 148827672 5226444 1024498..1024650 1 NC_009567.1 COG0140 Phosphoribosyl-ATP pyrophosphohydrolase; hypothetical protein 1024650 5226444 CGSHiGG_05635 Haemophilus influenzae PittGG hypothetical protein YP_001292425.1 1024498 D 374931 CDS YP_001292426.1 148827673 5226445 1024680..1025882 1 NC_009567.1 COG0814 Amino acid permeases; imidazole glycerol phosphate synthase subunit HisF 1025882 5226445 CGSHiGG_05640 Haemophilus influenzae PittGG imidazole glycerol phosphate synthase subunit HisF YP_001292426.1 1024680 D 374931 CDS YP_001292427.1 148827674 5226446 complement(1026069..1026497) 1 NC_009567.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 1026497 atpC 5226446 atpC Haemophilus influenzae PittGG F0F1 ATP synthase subunit epsilon YP_001292427.1 1026069 R 374931 CDS YP_001292428.1 148827675 5226447 complement(1026527..1027900) 1 NC_009567.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 1027900 5226447 CGSHiGG_05650 Haemophilus influenzae PittGG F0F1 ATP synthase subunit beta YP_001292428.1 1026527 R 374931 CDS YP_001292429.1 148827676 5226448 complement(1027917..1028786) 1 NC_009567.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 1028786 5226448 CGSHiGG_05655 Haemophilus influenzae PittGG F0F1 ATP synthase subunit gamma YP_001292429.1 1027917 R 374931 CDS YP_001292430.1 148827677 5226449 complement(1028802..1030343) 1 NC_009567.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 1030343 5226449 CGSHiGG_05660 Haemophilus influenzae PittGG F0F1 ATP synthase subunit alpha YP_001292430.1 1028802 R 374931 CDS YP_001292431.1 148827678 5226450 complement(1030356..1030889) 1 NC_009567.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 1030889 5226450 CGSHiGG_05665 Haemophilus influenzae PittGG F0F1 ATP synthase subunit delta YP_001292431.1 1030356 R 374931 CDS YP_001292432.1 148827679 5226451 complement(1030902..1031372) 1 NC_009567.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 1031372 5226451 CGSHiGG_05670 Haemophilus influenzae PittGG F0F1 ATP synthase subunit B YP_001292432.1 1030902 R 374931 CDS YP_001292433.1 148827680 5226452 complement(1031422..1031676) 1 NC_009567.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 1031676 5226452 CGSHiGG_05675 Haemophilus influenzae PittGG F0F1 ATP synthase subunit C YP_001292433.1 1031422 R 374931 CDS YP_001292434.1 148827681 5226453 complement(1031732..1032520) 1 NC_009567.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 1032520 5226453 CGSHiGG_05680 Haemophilus influenzae PittGG F0F1 ATP synthase subunit A YP_001292434.1 1031732 R 374931 CDS YP_001292435.1 148827682 5226454 complement(1032588..1032932) 1 NC_009567.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I 1032932 5226454 CGSHiGG_05685 Haemophilus influenzae PittGG F0F1 ATP synthase subunit I YP_001292435.1 1032588 R 374931 CDS YP_001292436.1 148827683 5226455 complement(1033058..1033669) 1 NC_009567.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 1033669 gidB 5226455 gidB Haemophilus influenzae PittGG 16S rRNA methyltransferase GidB YP_001292436.1 1033058 R 374931 CDS YP_001292437.1 148827684 5226456 complement(1033807..1034184) 1 NC_009567.1 COG0357 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division; hypothetical protein 1034184 5226456 CGSHiGG_05695 Haemophilus influenzae PittGG hypothetical protein YP_001292437.1 1033807 R 374931 CDS YP_001292438.1 148827685 5226457 1034299..1034901 1 NC_009567.1 COG0637 Predicted phosphatase/phosphohexomutase; putative phosphatase/phosphohexomutase 1034901 5226457 CGSHiGG_05700 Haemophilus influenzae PittGG putative phosphatase/phosphohexomutase YP_001292438.1 1034299 D 374931 CDS YP_001292439.1 148827686 5226458 1034901..1035374 1 NC_009567.1 COG1238 Predicted membrane protein; glucose-inhibited division protein B 1035374 gidB 5226458 gidB Haemophilus influenzae PittGG glucose-inhibited division protein B YP_001292439.1 1034901 D 374931 CDS YP_001292440.1 148827687 5226459 1035702..1036205 1 NC_009567.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 1036205 5226459 CGSHiGG_05710 Haemophilus influenzae PittGG S-ribosylhomocysteinase YP_001292440.1 1035702 D 374931 CDS YP_001292441.1 148827688 5226460 1036305..1036511 1 NC_009567.1 COG2963 Transposase and inactivated derivatives; hypothetical protein 1036511 5226460 CGSHiGG_05715 Haemophilus influenzae PittGG hypothetical protein YP_001292441.1 1036305 D 374931 CDS YP_001292442.1 148827689 5226461 1036842..1037057 1 NC_009567.1 COG2801 Transposase and inactivated derivatives; S-ribosylhomocysteinase 1037057 5226461 CGSHiGG_05720 Haemophilus influenzae PittGG S-ribosylhomocysteinase YP_001292442.1 1036842 D 374931 CDS YP_001292443.1 148827690 5226462 complement(1037149..1037856) 1 NC_009567.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 1037856 aphA 5226462 aphA Haemophilus influenzae PittGG acid phosphatase/phosphotransferase YP_001292443.1 1037149 R 374931 CDS YP_001292444.1 148827691 5226463 1038076..1038603 1 NC_009567.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 1038603 5226463 CGSHiGG_05730 Haemophilus influenzae PittGG ATP-dependent protease peptidase subunit YP_001292444.1 1038076 D 374931 CDS YP_001292445.1 148827692 5226464 complement(1040019..1041071) 1 NC_009567.1 COG0687 Spermidine/putrescine-binding periplasmic protein; spermidine/putrescine ABC transporter periplasmic-binding protein 1041071 5226464 CGSHiGG_05745 Haemophilus influenzae PittGG spermidine/putrescine ABC transporter periplasmic-binding protein YP_001292445.1 1040019 R 374931 CDS YP_001292446.1 148827693 5226465 1042671..1044113 1 NC_009567.1 COG1322 Uncharacterized protein conserved in bacteria; ATP-dependent protease ATP-binding subunit 1044113 hslU 5226465 hslU Haemophilus influenzae PittGG ATP-dependent protease ATP-binding subunit YP_001292446.1 1042671 D 374931 CDS YP_001292447.1 148827694 5226466 1044275..1044694 1 NC_009567.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 1044694 5226466 CGSHiGG_05765 Haemophilus influenzae PittGG D-ribose pyranase YP_001292447.1 1044275 D 374931 CDS YP_001292448.1 148827695 5226467 1044708..1046189 1 NC_009567.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP binding protein 1046189 5226467 CGSHiGG_05770 Haemophilus influenzae PittGG D-ribose transporter ATP binding protein YP_001292448.1 1044708 D 374931 CDS YP_001292449.1 148827696 5226468 1046219..1047187 1 NC_009567.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease protein 1047187 rbsC 5226468 rbsC Haemophilus influenzae PittGG ribose ABC transporter permease protein YP_001292449.1 1046219 D 374931 CDS YP_001292450.1 148827697 5226469 1047207..1048085 1 NC_009567.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 1048085 5226469 CGSHiGG_05780 Haemophilus influenzae PittGG D-ribose transporter subunit RbsB YP_001292450.1 1047207 D 374931 CDS YP_001292451.1 148827698 5226470 1048183..1049103 1 NC_009567.1 catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 1049103 5226470 CGSHiGG_05785 Haemophilus influenzae PittGG ribokinase YP_001292451.1 1048183 D 374931 CDS YP_001292452.1 148827699 5226471 1049131..1050129 1 NC_009567.1 COG1609 Transcriptional regulators; ribokinase 1050129 5226471 CGSHiGG_05790 Haemophilus influenzae PittGG ribokinase YP_001292452.1 1049131 D 374931 CDS YP_001292453.1 148827700 5226472 1050235..1050786 1 NC_009567.1 COG2862 Predicted membrane protein; hypothetical protein 1050786 5226472 CGSHiGG_05795 Haemophilus influenzae PittGG hypothetical protein YP_001292453.1 1050235 D 374931 CDS YP_001292454.1 148827701 5226473 complement(1050926..1051414) 1 NC_009567.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 1051414 5226473 CGSHiGG_05800 Haemophilus influenzae PittGG ribonuclease activity regulator protein RraA YP_001292454.1 1050926 R 374931 CDS YP_001292455.1 148827702 5226474 complement(1051466..1052356) 1 NC_009567.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 1052356 5226474 CGSHiGG_05805 Haemophilus influenzae PittGG 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_001292455.1 1051466 R 374931 CDS YP_001292456.1 148827703 5226475 1052439..1053158 1 NC_009567.1 COG1720 Uncharacterized conserved protein; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 1053158 5226475 CGSHiGG_05810 Haemophilus influenzae PittGG 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_001292456.1 1052439 D 374931 CDS YP_001292457.1 148827704 5226476 complement(1053211..1054155) 1 NC_009567.1 COG1275 Tellurite resistance protein and related permeases; potassium-tellurite ethidium and proflavin transporter 1054155 5226476 CGSHiGG_05815 Haemophilus influenzae PittGG potassium-tellurite ethidium and proflavin transporter YP_001292457.1 1053211 R 374931 CDS YP_001292458.1 148827705 5226477 complement(1054349..1058599) 1 NC_009567.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 1058599 5226477 CGSHiGG_05820 Haemophilus influenzae PittGG DNA-directed RNA polymerase subunit beta' YP_001292458.1 1054349 R 374931 CDS YP_001292459.1 148827706 5226478 complement(1058807..1062745) 1 NC_009567.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 1062745 rpoB 5226478 rpoB Haemophilus influenzae PittGG DNA-directed RNA polymerase subunit beta YP_001292459.1 1058807 R 374931 CDS YP_001292460.1 148827707 5226479 complement(1063221..1063910) 1 NC_009567.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 1063910 rplA 5226479 rplA Haemophilus influenzae PittGG 50S ribosomal protein L1 YP_001292460.1 1063221 R 374931 CDS YP_001292461.1 148827708 5226480 complement(1063915..1064343) 1 NC_009567.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 1064343 rplK 5226480 rplK Haemophilus influenzae PittGG 50S ribosomal protein L11 YP_001292461.1 1063915 R 374931 CDS YP_001292462.1 148827709 5226481 complement(1064514..1065230) 1 NC_009567.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 1065230 deoD 5226481 deoD Haemophilus influenzae PittGG purine nucleoside phosphorylase YP_001292462.1 1064514 R 374931 CDS YP_001292463.1 148827710 5226482 complement(1065314..1066567) 1 NC_009567.1 COG1972 Nucleoside permease; nucleoside permease 1066567 5226482 CGSHiGG_05845 Haemophilus influenzae PittGG nucleoside permease YP_001292463.1 1065314 R 374931 CDS YP_001292464.1 148827711 5226483 complement(1066666..1067454) 1 NC_009567.1 COG1180 Pyruvate-formate lyase-activating enzyme; purine nucleoside phosphorylase 1067454 deoD 5226483 deoD Haemophilus influenzae PittGG purine nucleoside phosphorylase YP_001292464.1 1066666 R 374931 CDS YP_001292465.1 148827712 5226484 complement(1067463..1069007) 1 NC_009567.1 COG1882 Pyruvate-formate lyase; hypothetical protein 1069007 5226484 CGSHiGG_05855 Haemophilus influenzae PittGG hypothetical protein YP_001292465.1 1067463 R 374931 CDS YP_001292466.1 148827713 5226485 1069220..1069876 1 NC_009567.1 COG2364 Predicted membrane protein; hypothetical protein 1069876 5226485 CGSHiGG_05860 Haemophilus influenzae PittGG hypothetical protein YP_001292466.1 1069220 D 374931 CDS YP_001292467.1 148827714 5226486 complement(1069832..1070872) 1 NC_009567.1 COG0859 ADP-heptose:LPS heptosyltransferase; hypothetical protein 1070872 5226486 CGSHiGG_05865 Haemophilus influenzae PittGG hypothetical protein YP_001292467.1 1069832 R 374931 CDS YP_001292468.1 148827715 5226487 complement(1070940..1072019) 1 NC_009567.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 1072019 5226487 CGSHiGG_05870 Haemophilus influenzae PittGG fructose-bisphosphate aldolase YP_001292468.1 1070940 R 374931 CDS YP_001292469.1 148827716 5226488 complement(1072130..1073290) 1 NC_009567.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 1073290 pgk 5226488 pgk Haemophilus influenzae PittGG phosphoglycerate kinase YP_001292469.1 1072130 R 374931 CDS YP_001292470.1 148827717 5226489 complement(1073386..1074180) 1 NC_009567.1 COG3719 Ribonuclease I; ribonuclease I 1074180 5226489 CGSHiGG_05880 Haemophilus influenzae PittGG ribonuclease I YP_001292470.1 1073386 R 374931 CDS YP_001292471.1 148827718 5226490 1074258..1074518 1 NC_009567.1 COG1145 Ferredoxin; ferredoxin 1074518 5226490 CGSHiGG_05885 Haemophilus influenzae PittGG ferredoxin YP_001292471.1 1074258 D 374931 CDS YP_001292472.1 148827719 5226491 complement(1074656..1075876) 1 NC_009567.1 COG0814 Amino acid permeases; phosphoglycerate kinase 1075876 pgk 5226491 pgk Haemophilus influenzae PittGG phosphoglycerate kinase YP_001292472.1 1074656 R 374931 CDS YP_001292473.1 148827720 5226492 complement(1075913..1076494) 1 NC_009567.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1076494 5226492 CGSHiGG_05895 Haemophilus influenzae PittGG thymidine kinase YP_001292473.1 1075913 R 374931 CDS YP_001292474.1 148827721 5226493 complement(1076503..1077531) 1 NC_009567.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 1077531 5226493 CGSHiGG_05900 Haemophilus influenzae PittGG putative DNA-binding/iron metalloprotein/AP endonuclease YP_001292474.1 1076503 R 374931 CDS YP_001292475.1 148827722 5226494 1077763..1077978 1 NC_009567.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1077978 rpsU 5226494 rpsU Haemophilus influenzae PittGG 30S ribosomal protein S21 YP_001292475.1 1077763 D 374931 CDS YP_001292476.1 148827723 5226495 1078112..1079893 1 NC_009567.1 synthesizes RNA primers at the replication forks; DNA primase 1079893 dnaG 5226495 dnaG Haemophilus influenzae PittGG DNA primase YP_001292476.1 1078112 D 374931 CDS YP_001292477.1 148827724 5226496 1079963..1081852 1 NC_009567.1 DNA primase 1081852 5226496 CGSHiGG_05915 Haemophilus influenzae PittGG DNA primase YP_001292477.1 1079963 D 374931 CDS YP_001292478.1 148827725 5226497 1082020..1082106 1 NC_009567.1 COG0568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32); hypothetical protein 1082106 5226497 CGSHiGG_05920 Haemophilus influenzae PittGG hypothetical protein YP_001292478.1 1082020 D 374931 CDS YP_001292479.1 148827726 5226498 complement(1082152..1083570) 1 NC_009567.1 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 1083570 aspA 5226498 aspA Haemophilus influenzae PittGG aspartate ammonia-lyase YP_001292479.1 1082152 R 374931 CDS YP_001292480.1 148827727 5226499 complement(1083725..1084468) 1 NC_009567.1 COG0829 Urease accessory protein UreH; urease accessory protein UreH 1084468 5226499 CGSHiGG_05930 Haemophilus influenzae PittGG urease accessory protein UreH YP_001292480.1 1083725 R 374931 CDS YP_001292481.1 148827728 5226500 complement(1084615..1085250) 1 NC_009567.1 COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; urease accessory protein 1085250 5226500 CGSHiGG_05935 Haemophilus influenzae PittGG urease accessory protein YP_001292481.1 1084615 R 374931 CDS YP_001292482.1 148827729 5226501 complement(1085395..1086102) 1 NC_009567.1 COG0830 Urease accessory protein UreF; urease accessory protein UreF 1086102 5226501 CGSHiGG_05940 Haemophilus influenzae PittGG urease accessory protein UreF YP_001292482.1 1085395 R 374931 CDS YP_001292483.1 148827730 5226502 complement(1086087..1086644) 1 NC_009567.1 involved in the assembly of the urease metallocenter; possible nickel donor; urease accessory protein UreE 1086644 ureE 5226502 ureE Haemophilus influenzae PittGG urease accessory protein UreE YP_001292483.1 1086087 R 374931 CDS YP_001292484.1 148827731 5226503 complement(1086772..1088490) 1 NC_009567.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 1088490 ureC 5226503 ureC Haemophilus influenzae PittGG urease subunit alpha YP_001292484.1 1086772 R 374931 CDS YP_001292485.1 148827732 5226504 complement(1088883..1089185) 1 NC_009567.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 1089185 ureA 5226504 ureA Haemophilus influenzae PittGG urease subunit gamma YP_001292485.1 1088883 R 374931 CDS YP_001292486.1 148827733 5226505 1089349..1089639 1 NC_009567.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 1089639 groES 5226505 groES Haemophilus influenzae PittGG co-chaperonin GroES YP_001292486.1 1089349 D 374931 CDS YP_001292487.1 148827734 5226506 1089659..1091305 1 NC_009567.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 1091305 groEL 5226506 groEL Haemophilus influenzae PittGG chaperonin GroEL YP_001292487.1 1089659 D 374931 CDS YP_001292488.1 148827735 5226507 complement(1091478..1091927) 1 NC_009567.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 1091927 rplI 5226507 rplI Haemophilus influenzae PittGG 50S ribosomal protein L9 YP_001292488.1 1091478 R 374931 CDS YP_001292489.1 148827736 5226508 complement(1091944..1092171) 1 NC_009567.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 1092171 rpsR 5226508 rpsR Haemophilus influenzae PittGG 30S ribosomal protein S18 YP_001292489.1 1091944 R 374931 CDS YP_001292490.1 148827737 5226509 complement(1092184..1092402) 1 NC_009567.1 COG2965 Primosomal replication protein N; primosomal replication protein N 1092402 5226509 CGSHiGG_05990 Haemophilus influenzae PittGG primosomal replication protein N YP_001292490.1 1092184 R 374931 CDS YP_001292491.1 148827738 5226510 complement(1092498..1092875) 1 NC_009567.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 1092875 rpsF 5226510 rpsF Haemophilus influenzae PittGG 30S ribosomal protein S6 YP_001292491.1 1092498 R 374931 CDS YP_001292492.1 148827739 5226511 complement(1093075..1093293) 1 NC_009567.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 1093293 infA 5226511 infA Haemophilus influenzae PittGG translation initiation factor IF-1 YP_001292492.1 1093075 R 374931 CDS YP_001292493.1 148827740 5226512 1093430..1094266 1 NC_009567.1 lipooligosaccharide galactosyltransferase II 1094266 5226512 CGSHiGG_06005 Haemophilus influenzae PittGG lipooligosaccharide galactosyltransferase II YP_001292493.1 1093430 D 374931 CDS YP_001292494.1 148827741 5226513 1094297..1094854 1 NC_009567.1 COG3306 Glycosyltransferase involved in LPS biosynthesis; lipooligosaccharide glycosyl transferase G 1094854 5226513 CGSHiGG_06010 Haemophilus influenzae PittGG lipooligosaccharide glycosyl transferase G YP_001292494.1 1094297 D 374931 CDS YP_001292495.1 148827742 5226514 1095028..1095348 1 NC_009567.1 COG0438 Glycosyltransferase; translation initiation factor IF-1 1095348 infA 5226514 infA Haemophilus influenzae PittGG translation initiation factor IF-1 YP_001292495.1 1095028 D 374931 CDS YP_001292496.1 148827743 5226515 1095431..1096294 1 NC_009567.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 1096294 ksgA 5226515 ksgA Haemophilus influenzae PittGG dimethyladenosine transferase YP_001292496.1 1095431 D 374931 CDS YP_001292497.1 148827744 5226516 1097368..1098195 1 NC_009567.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 1098195 apaH 5226516 apaH Haemophilus influenzae PittGG diadenosine tetraphosphatase YP_001292497.1 1097368 D 374931 CDS YP_001292498.1 148827745 5226517 1098205..1098828 1 NC_009567.1 COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases; diadenosine tetraphosphatase 1098828 apaH 5226517 apaH Haemophilus influenzae PittGG diadenosine tetraphosphatase YP_001292498.1 1098205 D 374931 CDS YP_001292499.1 148827746 5226518 complement(1098954..1100408) 1 NC_009567.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 1100408 5226518 CGSHiGG_06045 Haemophilus influenzae PittGG 6-phosphogluconate dehydrogenase YP_001292499.1 1098954 R 374931 CDS YP_001292500.1 148827747 5226519 complement(1100690..1101223) 1 NC_009567.1 COG1943 Transposase and inactivated derivatives; hypothetical protein 1101223 5226519 CGSHiGG_06050 Haemophilus influenzae PittGG hypothetical protein YP_001292500.1 1100690 R 374931 CDS YP_001292501.1 148827748 5226520 complement(1101345..1101506) 1 NC_009567.1 COG3759 Predicted membrane protein; hypothetical protein 1101506 5226520 CGSHiGG_06055 Haemophilus influenzae PittGG hypothetical protein YP_001292501.1 1101345 R 374931 CDS YP_001292502.1 148827749 5226521 complement(1101586..1102284) 1 NC_009567.1 COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase; 6-phosphogluconate dehydrogenase 1102284 5226521 CGSHiGG_06060 Haemophilus influenzae PittGG 6-phosphogluconate dehydrogenase YP_001292502.1 1101586 R 374931 CDS YP_001292503.1 148827750 5226522 complement(1102365..1103849) 1 NC_009567.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1103849 5226522 CGSHiGG_06065 Haemophilus influenzae PittGG glucose-6-phosphate 1-dehydrogenase YP_001292503.1 1102365 R 374931 CDS YP_001292504.1 148827751 5226523 complement(1103925..1104734) 1 NC_009567.1 3'(2'),5'-bisphosphate nucleotidase CysQ 1104734 5226523 CGSHiGG_06070 Haemophilus influenzae PittGG 3'(2'),5'-bisphosphate nucleotidase CysQ YP_001292504.1 1103925 R 374931 CDS YP_001292505.1 148827752 5226524 complement(1104739..1105155) 1 NC_009567.1 COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase; hypothetical protein 1105155 5226524 CGSHiGG_06075 Haemophilus influenzae PittGG hypothetical protein YP_001292505.1 1104739 R 374931 CDS YP_001292506.1 148827753 5226525 complement(1105208..1107196) 1 NC_009567.1 COG1297 Predicted membrane protein; hypothetical protein 1107196 5226525 CGSHiGG_06080 Haemophilus influenzae PittGG hypothetical protein YP_001292506.1 1105208 R 374931 CDS YP_001292507.1 148827754 5226526 1107425..1107790 1 NC_009567.1 COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog); glucose-6-phosphate 1-dehydrogenase 1107790 5226526 CGSHiGG_06085 Haemophilus influenzae PittGG glucose-6-phosphate 1-dehydrogenase YP_001292507.1 1107425 D 374931 CDS YP_001292508.1 148827755 5226527 complement(1107845..1108297) 1 NC_009567.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 1108297 5226527 CGSHiGG_06090 Haemophilus influenzae PittGG DNA-binding transcriptional regulator AsnC YP_001292508.1 1107845 R 374931 CDS YP_001292509.1 148827756 5226528 1108451..1109443 1 NC_009567.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 1109443 5226528 CGSHiGG_06095 Haemophilus influenzae PittGG asparagine synthetase AsnA YP_001292509.1 1108451 D 374931 CDS YP_001292510.1 148827757 5226529 complement(1109508..1110182) 1 NC_009567.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 1110182 5226529 CGSHiGG_06100 Haemophilus influenzae PittGG phosphoglycolate phosphatase YP_001292510.1 1109508 R 374931 CDS YP_001292511.1 148827758 5226530 complement(1110228..1110902) 1 NC_009567.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 1110902 5226530 CGSHiGG_06105 Haemophilus influenzae PittGG ribulose-phosphate 3-epimerase YP_001292511.1 1110228 R 374931 CDS YP_001292512.1 148827759 5226531 complement(1111054..1113474) 1 NC_009567.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 1113474 gyrB 5226531 gyrB Haemophilus influenzae PittGG DNA gyrase subunit B YP_001292512.1 1111054 R 374931 CDS YP_001292513.1 148827760 5226532 complement(1113600..1115912) 1 NC_009567.1 COG2183 Transcriptional accessory protein; DNA gyrase subunit B 1115912 gyrB 5226532 gyrB Haemophilus influenzae PittGG DNA gyrase subunit B YP_001292513.1 1113600 R 374931 CDS YP_001292514.1 148827761 5226533 1116006..1116482 1 NC_009567.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 1116482 greB 5226533 greB Haemophilus influenzae PittGG transcription elongation factor GreB YP_001292514.1 1116006 D 374931 CDS YP_001292515.1 148827762 5226534 complement(1116552..1117169) 1 NC_009567.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 1117169 5226534 CGSHiGG_06125 Haemophilus influenzae PittGG DNA-binding transcriptional repressor FabR YP_001292515.1 1116552 R 374931 CDS YP_001292516.1 148827763 5226535 complement(1117169..1118074) 1 NC_009567.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 1118074 5226535 CGSHiGG_06130 Haemophilus influenzae PittGG DNA-binding transcriptional regulator OxyR YP_001292516.1 1117169 R 374931 CDS YP_001292517.1 148827764 5226536 1118197..1118922 1 NC_009567.1 COG0678 Peroxiredoxin; DNA-binding transcriptional regulator OxyR 1118922 5226536 CGSHiGG_06135 Haemophilus influenzae PittGG DNA-binding transcriptional regulator OxyR YP_001292517.1 1118197 D 374931 CDS YP_001292518.1 148827765 5226537 complement(1119010..1119231) 1 NC_009567.1 COG2900 Uncharacterized protein conserved in bacteria; hypothetical protein 1119231 5226537 CGSHiGG_06140 Haemophilus influenzae PittGG hypothetical protein YP_001292518.1 1119010 R 374931 CDS YP_001292519.1 148827766 5226538 1119329..1120054 1 NC_009567.1 COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1; FKBP-type peptidyl-prolyl cis-trans isomerase 1120054 5226538 CGSHiGG_06145 Haemophilus influenzae PittGG FKBP-type peptidyl-prolyl cis-trans isomerase YP_001292519.1 1119329 D 374931 CDS YP_001292520.1 148827767 5226539 1120144..1120809 1 NC_009567.1 COG2964 Uncharacterized protein conserved in bacteria; hypothetical protein 1120809 5226539 CGSHiGG_06150 Haemophilus influenzae PittGG hypothetical protein YP_001292520.1 1120144 D 374931 CDS YP_001292521.1 148827768 5226540 1120809..1121189 1 NC_009567.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 1121189 5226540 CGSHiGG_06155 Haemophilus influenzae PittGG sulfur transfer complex subunit TusD YP_001292521.1 1120809 D 374931 CDS YP_001292522.1 148827769 5226541 1121553..1121840 1 NC_009567.1 COG2168 Uncharacterized conserved protein involved in oxidation of intracellular sulfur; hypothetical protein 1121840 5226541 CGSHiGG_06170 Haemophilus influenzae PittGG hypothetical protein YP_001292522.1 1121553 D 374931 CDS YP_001292523.1 148827770 5226542 1123861..1124784 1 NC_009567.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 1124784 5226542 CGSHiGG_06185 Haemophilus influenzae PittGG pantothenate kinase YP_001292523.1 1123861 D 374931 CDS YP_001292524.1 148827771 5226543 complement(1124874..1125821) 1 NC_009567.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE 1125821 rseB 5226543 rseB Haemophilus influenzae PittGG periplasmic negative regulator of sigmaE YP_001292524.1 1124874 R 374931 CDS YP_001292525.1 148827772 5226544 complement(1125901..1126488) 1 NC_009567.1 COG3073 Negative regulator of sigma E activity; sigma-E factor negative regulatory protein 1126488 5226544 CGSHiGG_06195 Haemophilus influenzae PittGG sigma-E factor negative regulatory protein YP_001292525.1 1125901 R 374931 CDS YP_001292526.1 148827773 5226545 complement(1126513..1127082) 1 NC_009567.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 1127082 5226545 CGSHiGG_06200 Haemophilus influenzae PittGG RNA polymerase sigma factor RpoE YP_001292526.1 1126513 R 374931 CDS YP_001292527.1 148827774 5226546 complement(1127190..1127447) 1 NC_009567.1 COG2938 Uncharacterized conserved protein; hypothetical protein 1127447 5226546 CGSHiGG_06205 Haemophilus influenzae PittGG hypothetical protein YP_001292527.1 1127190 R 374931 CDS YP_001292528.1 148827775 5226547 complement(1127538..1127924) 1 NC_009567.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 1127924 mscL 5226547 mscL Haemophilus influenzae PittGG large-conductance mechanosensitive channel YP_001292528.1 1127538 R 374931 CDS YP_001292529.1 148827776 5226548 complement(1127997..1129373) 1 NC_009567.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 1129373 trkA 5226548 trkA Haemophilus influenzae PittGG potassium transporter peripheral membrane component YP_001292529.1 1127997 R 374931 CDS YP_001292530.1 148827777 5226549 complement(1130742..1131698) 1 NC_009567.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 1131698 fmt 5226549 fmt Haemophilus influenzae PittGG methionyl-tRNA formyltransferase YP_001292530.1 1130742 R 374931 CDS YP_001292531.1 148827778 5226550 complement(1131792..1132301) 1 NC_009567.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1132301 def 5226550 def Haemophilus influenzae PittGG peptide deformylase YP_001292531.1 1131792 R 374931 CDS YP_001292532.1 148827779 5226551 complement(1132396..1132890) 1 NC_009567.1 hypothetical protein 1132890 5226551 CGSHiGG_06240 Haemophilus influenzae PittGG hypothetical protein YP_001292532.1 1132396 R 374931 CDS YP_001292533.1 148827780 5226552 complement(1132900..1133361) 1 NC_009567.1 hypothetical protein 1133361 5226552 CGSHiGG_06245 Haemophilus influenzae PittGG hypothetical protein YP_001292533.1 1132900 R 374931 CDS YP_001292534.1 148827781 5226553 complement(1133377..1133658) 1 NC_009567.1 hypothetical protein 1133658 5226553 CGSHiGG_06250 Haemophilus influenzae PittGG hypothetical protein YP_001292534.1 1133377 R 374931 CDS YP_001292536.1 148827783 5226555 complement(1133771..1133998) 1 NC_009567.1 hypothetical protein 1133998 5226555 CGSHiGG_06260 Haemophilus influenzae PittGG hypothetical protein YP_001292536.1 1133771 R 374931 CDS YP_001292537.1 148827784 5226558 complement(1140032..1140568) 1 NC_009567.1 hypothetical protein 1140568 5226558 CGSHiGG_06265 Haemophilus influenzae PittGG hypothetical protein YP_001292537.1 1140032 R 374931 CDS YP_001292538.1 148827785 5226559 1141056..1142120 1 NC_009567.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1142120 recA 5226559 recA Haemophilus influenzae PittGG recombinase A YP_001292538.1 1141056 D 374931 CDS YP_001292539.1 148827786 5226560 1142200..1142658 1 NC_009567.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1142658 recX 5226560 recX Haemophilus influenzae PittGG recombination regulator RecX YP_001292539.1 1142200 D 374931 CDS YP_001292540.1 148827787 5226561 complement(1142655..1143041) 1 NC_009567.1 COG0239 Integral membrane protein possibly involved in chromosome condensation; camphor resistance protein CrcB 1143041 5226561 CGSHiGG_06280 Haemophilus influenzae PittGG camphor resistance protein CrcB YP_001292540.1 1142655 R 374931 CDS YP_001292541.1 148827788 5226562 complement(1143041..1143859) 1 NC_009567.1 COG0561 Predicted hydrolases of the HAD superfamily; recombination regulator RecX 1143859 recX 5226562 recX Haemophilus influenzae PittGG recombination regulator RecX YP_001292541.1 1143041 R 374931 CDS YP_001292542.1 148827789 5226563 1144263..1145267 1 NC_009567.1 COG0078 Ornithine carbamoyltransferase; ornithine carbamoyltransferase 1145267 5226563 CGSHiGG_06290 Haemophilus influenzae PittGG ornithine carbamoyltransferase YP_001292542.1 1144263 D 374931 CDS YP_001292543.1 148827790 5226564 1145277..1146209 1 NC_009567.1 reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 1146209 5226564 CGSHiGG_06295 Haemophilus influenzae PittGG carbamate kinase YP_001292543.1 1145277 D 374931 CDS YP_001292544.1 148827791 5226565 1146319..1147845 1 NC_009567.1 COG1288 Predicted membrane protein; hypothetical protein 1147845 5226565 CGSHiGG_06300 Haemophilus influenzae PittGG hypothetical protein YP_001292544.1 1146319 D 374931 CDS YP_001292545.1 148827792 5226566 1147935..1148117 1 NC_009567.1 COG1522 Transcriptional regulators; carbamate kinase 1148117 5226566 CGSHiGG_06305 Haemophilus influenzae PittGG carbamate kinase YP_001292545.1 1147935 D 374931 CDS YP_001292546.1 148827793 5226567 1148239..1148400 1 NC_009567.1 COG1522 Transcriptional regulators; hypothetical protein 1148400 5226567 CGSHiGG_06310 Haemophilus influenzae PittGG hypothetical protein YP_001292546.1 1148239 D 374931 CDS YP_001292547.1 148827794 5226568 1148447..1148632 1 NC_009567.1 ornithine carbamoyltransferase 1148632 5226568 CGSHiGG_06315 Haemophilus influenzae PittGG ornithine carbamoyltransferase YP_001292547.1 1148447 D 374931 CDS YP_001292548.1 148827795 5226569 1148931..1149038 1 NC_009567.1 COG0078 Ornithine carbamoyltransferase; hypothetical protein 1149038 5226569 CGSHiGG_06320 Haemophilus influenzae PittGG hypothetical protein YP_001292548.1 1148931 D 374931 CDS YP_001292549.1 148827796 5226570 1149290..1151452 1 NC_009567.1 COG1982 Arginine/lysine/ornithine decarboxylases; ornithine decarboxylase 1151452 5226570 CGSHiGG_06325 Haemophilus influenzae PittGG ornithine decarboxylase YP_001292549.1 1149290 D 374931 CDS YP_001292550.1 148827797 5226571 1151559..1152875 1 NC_009567.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter 1152875 potE 5226571 potE Haemophilus influenzae PittGG putrescine transporter YP_001292550.1 1151559 D 374931 CDS YP_001292551.1 148827798 5226572 complement(1152982..1153398) 1 NC_009567.1 COG3086 Positive regulator of sigma E activity; putrescine/proton symporter: putrescine/ornithine antiporter 1153398 5226572 CGSHiGG_06335 Haemophilus influenzae PittGG putrescine/proton symporter: putrescine/ornithine antiporter YP_001292551.1 1152982 R 374931 CDS YP_001292552.1 148827799 5226573 complement(1153617..1154852) 1 NC_009567.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase 1154852 5226573 CGSHiGG_06340 Haemophilus influenzae PittGG allantoate amidohydrolase YP_001292552.1 1153617 R 374931 CDS YP_001292553.1 148827800 5226574 1154976..1155680 1 NC_009567.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E 1155680 5226574 CGSHiGG_06345 Haemophilus influenzae PittGG peptidase E YP_001292553.1 1154976 D 374931 CDS YP_001292554.1 148827801 5226575 1155698..1156993 1 NC_009567.1 COG3069 C4-dicarboxylate transporter; C4-dicarboxylate transporter 1156993 5226575 CGSHiGG_06350 Haemophilus influenzae PittGG C4-dicarboxylate transporter YP_001292554.1 1155698 D 374931 CDS YP_001292555.1 148827802 5226576 complement(1160511..1160903) 1 NC_009567.1 COG0789 Predicted transcriptional regulators; HTH-type transcriptional regulator 1160903 5226576 CGSHiGG_06375 Haemophilus influenzae PittGG HTH-type transcriptional regulator YP_001292555.1 1160511 R 374931 CDS YP_001292556.1 148827803 5226577 complement(1160928..1161605) 1 NC_009567.1 COG1230 Co/Zn/Cd efflux system component; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein 1161605 cpdB 5226577 cpdB Haemophilus influenzae PittGG bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein YP_001292556.1 1160928 R 374931 CDS YP_001292557.1 148827804 5226578 1162109..1163998 1 NC_009567.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 1163998 5226578 CGSHiGG_06385 Haemophilus influenzae PittGG tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA YP_001292557.1 1162109 D 374931 CDS YP_001292558.1 148827805 5226579 1164180..1164554 1 NC_009567.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 1164554 rpsL 5226579 rpsL Haemophilus influenzae PittGG 30S ribosomal protein S12 YP_001292558.1 1164180 D 374931 CDS YP_001292559.1 148827806 5226580 1164712..1165182 1 NC_009567.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 1165182 5226580 CGSHiGG_06395 Haemophilus influenzae PittGG 30S ribosomal protein S7 YP_001292559.1 1164712 D 374931 CDS YP_001292560.1 148827807 5226581 1167434..1168618 1 NC_009567.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 1168618 5226581 CGSHiGG_06410 Haemophilus influenzae PittGG elongation factor Tu YP_001292560.1 1167434 D 374931 CDS YP_001292561.1 148827808 5226582 1169144..1169422 1 NC_009567.1 COG0038 Chloride channel protein EriC; chloride channel protein 1169422 5226582 CGSHiGG_06415 Haemophilus influenzae PittGG chloride channel protein YP_001292561.1 1169144 D 374931 CDS YP_001292562.1 148827809 5226583 1169419..1169595 1 NC_009567.1 COG0038 Chloride channel protein EriC; elongation factor G 1169595 5226583 CGSHiGG_06420 Haemophilus influenzae PittGG elongation factor G YP_001292562.1 1169419 D 374931 CDS YP_001292563.1 148827810 5226584 1169598..1170581 1 NC_009567.1 COG0042 tRNA-dihydrouridine synthase; tRNA-dihydrouridine synthase A 1170581 5226584 CGSHiGG_06425 Haemophilus influenzae PittGG tRNA-dihydrouridine synthase A YP_001292563.1 1169598 D 374931 CDS YP_001292564.1 148827811 5226585 complement(1170795..1173998) 1 NC_009567.1 hemoglobin-binding protein 1173998 5226585 CGSHiGG_06430 Haemophilus influenzae PittGG hemoglobin-binding protein YP_001292564.1 1170795 R 374931 CDS YP_001292565.1 148827812 5226586 1174402..1174572 1 NC_009567.1 COG1629 Outer membrane receptor proteins, mostly Fe transport; hypothetical protein 1174572 5226586 CGSHiGG_06435 Haemophilus influenzae PittGG hypothetical protein YP_001292565.1 1174402 D 374931 CDS YP_001292566.1 148827813 5226587 complement(1174620..1174910) 1 NC_009567.1 COG3691 Uncharacterized protein conserved in bacteria; tRNA-dihydrouridine synthase A 1174910 5226587 CGSHiGG_06440 Haemophilus influenzae PittGG tRNA-dihydrouridine synthase A YP_001292566.1 1174620 R 374931 CDS YP_001292567.1 148827814 5226588 complement(1174932..1175936) 1 NC_009567.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 1175936 5226588 CGSHiGG_06445 Haemophilus influenzae PittGG tryptophanyl-tRNA synthetase YP_001292567.1 1174932 R 374931 CDS YP_001292568.1 148827815 5226589 1176065..1176682 1 NC_009567.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 1176682 5226589 CGSHiGG_06450 Haemophilus influenzae PittGG hypothetical protein YP_001292568.1 1176065 D 374931 CDS YP_001292569.1 148827816 5226590 1176705..1178075 1 NC_009567.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1178075 5226590 CGSHiGG_06455 Haemophilus influenzae PittGG adenylosuccinate lyase YP_001292569.1 1176705 D 374931 CDS YP_001292570.1 148827817 5226591 1178347..1178838 1 NC_009567.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 1178838 rplJ 5226591 rplJ Haemophilus influenzae PittGG 50S ribosomal protein L10 YP_001292570.1 1178347 D 374931 CDS YP_001292571.1 148827818 5226592 1178893..1179264 1 NC_009567.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 1179264 rplL 5226592 rplL Haemophilus influenzae PittGG 50S ribosomal protein L7/L12 YP_001292571.1 1178893 D 374931 CDS YP_001292572.1 148827819 5226593 1179426..1180796 1 NC_009567.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 1180796 glmU 5226593 glmU Haemophilus influenzae PittGG bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_001292572.1 1179426 D 374931 CDS YP_001292573.1 148827820 5226594 complement(1180837..1181148) 1 NC_009567.1 COG0805 Sec-independent protein secretion pathway component TatC; hypothetical protein 1181148 5226594 CGSHiGG_06475 Haemophilus influenzae PittGG hypothetical protein YP_001292573.1 1180837 R 374931 CDS YP_001292574.1 148827821 5226595 complement(1184355..1185455) 1 NC_009567.1 COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit; cytochrome C-like protein 1185455 5226595 CGSHiGG_06495 Haemophilus influenzae PittGG cytochrome C-like protein YP_001292574.1 1184355 R 374931 CDS YP_001292575.1 148827822 5226596 complement(1185612..1186553) 1 NC_009567.1 COG2267 Lysophospholipase; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 1186553 glmU 5226596 glmU Haemophilus influenzae PittGG bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_001292575.1 1185612 R 374931 CDS YP_001292576.1 148827823 5226597 complement(1186607..1187722) 1 NC_009567.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 1187722 5226597 CGSHiGG_06505 Haemophilus influenzae PittGG aspartate-semialdehyde dehydrogenase YP_001292576.1 1186607 R 374931 CDS YP_001292577.1 148827824 5226598 complement(1187888..1188604) 1 NC_009567.1 COG1285 Uncharacterized membrane protein; hypothetical protein 1188604 5226598 CGSHiGG_06510 Haemophilus influenzae PittGG hypothetical protein YP_001292577.1 1187888 R 374931 CDS YP_001292578.1 148827825 5226599 1188798..1189454 1 NC_009567.1 COG0621 2-methylthioadenine synthetase; 2-methylthioadenine synthetase 1189454 5226599 CGSHiGG_06515 Haemophilus influenzae PittGG 2-methylthioadenine synthetase YP_001292578.1 1188798 D 374931 CDS YP_001292579.1 148827826 5226600 complement(1189518..1190006) 1 NC_009567.1 COG2249 Putative NADPH-quinone reductase (modulator of drug activity B); modulator of drug activity B 1190006 5226600 CGSHiGG_06520 Haemophilus influenzae PittGG modulator of drug activity B YP_001292579.1 1189518 R 374931 CDS YP_001292580.1 148827827 5226601 complement(1190377..1192389) 1 NC_009567.1 ATP-dependent DNA helicase 1192389 5226601 CGSHiGG_06525 Haemophilus influenzae PittGG ATP-dependent DNA helicase YP_001292580.1 1190377 R 374931 CDS YP_001292581.1 148827828 5226602 complement(1192395..1192607) 1 NC_009567.1 COG0210 Superfamily I DNA and RNA helicases; aspartate-semialdehyde dehydrogenase 1192607 5226602 CGSHiGG_06530 Haemophilus influenzae PittGG aspartate-semialdehyde dehydrogenase YP_001292581.1 1192395 R 374931 CDS YP_001292582.1 148827829 5226603 complement(1192604..1193074) 1 NC_009567.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1193074 coaD 5226603 coaD Haemophilus influenzae PittGG phosphopantetheine adenylyltransferase YP_001292582.1 1192604 R 374931 CDS YP_001292583.1 148827830 5226604 complement(1193071..1194354) 1 NC_009567.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 1194354 5226604 CGSHiGG_06540 Haemophilus influenzae PittGG 3-deoxy-D-manno-octulosonic-acid transferase YP_001292583.1 1193071 R 374931 CDS YP_001292584.1 148827831 5226605 1194417..1195181 1 NC_009567.1 COG0463 Glycosyltransferases involved in cell wall biogenesis; UDP-glucose--lipooligosaccharide glucosyltransferase 1195181 5226605 CGSHiGG_06545 Haemophilus influenzae PittGG UDP-glucose--lipooligosaccharide glucosyltransferase YP_001292584.1 1194417 D 374931 CDS YP_001292585.1 148827832 5226606 complement(1195178..1195834) 1 NC_009567.1 DNA-3-methyladenine glycosylase 1195834 5226606 CGSHiGG_06550 Haemophilus influenzae PittGG DNA-3-methyladenine glycosylase YP_001292585.1 1195178 R 374931 CDS YP_001292586.1 148827833 5226607 complement(1195851..1196609) 1 NC_009567.1 COG2818 3-methyladenine DNA glycosylase; 3-deoxy-D-manno-octulosonic-acid transferase 1196609 5226607 CGSHiGG_06555 Haemophilus influenzae PittGG 3-deoxy-D-manno-octulosonic-acid transferase YP_001292586.1 1195851 R 374931 CDS YP_001292587.1 148827834 5226608 complement(1196621..1197427) 1 NC_009567.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 1197427 aroE 5226608 aroE Haemophilus influenzae PittGG shikimate 5-dehydrogenase YP_001292587.1 1196621 R 374931 CDS YP_001292588.1 148827835 5226609 complement(1197431..1197982) 1 NC_009567.1 COG0009 Putative translation factor (SUA5); hypothetical protein 1197982 5226609 CGSHiGG_06565 Haemophilus influenzae PittGG hypothetical protein YP_001292588.1 1197431 R 374931 CDS YP_001292589.1 148827836 5226610 complement(1197998..1198534) 1 NC_009567.1 COG0551 Zn-finger domain associated with topoisomerase type I; hypothetical protein 1198534 5226610 CGSHiGG_06570 Haemophilus influenzae PittGG hypothetical protein YP_001292589.1 1197998 R 374931 CDS YP_001292590.1 148827837 5226611 complement(1198544..1200460) 1 NC_009567.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains; ABC transporter ATP-binding protein 1200460 5226611 CGSHiGG_06575 Haemophilus influenzae PittGG ABC transporter ATP-binding protein YP_001292590.1 1198544 R 374931 CDS YP_001292591.1 148827838 5226612 complement(1200621..1200917) 1 NC_009567.1 COG1396 Predicted transcriptional regulators; putative HTH-type transcriptional regulator 1200917 5226612 CGSHiGG_06580 Haemophilus influenzae PittGG putative HTH-type transcriptional regulator YP_001292591.1 1200621 R 374931 CDS YP_001292592.1 148827839 5226613 complement(1200910..1201269) 1 NC_009567.1 COG4679 Phage-related protein; hypothetical protein 1201269 5226613 CGSHiGG_06585 Haemophilus influenzae PittGG hypothetical protein YP_001292592.1 1200910 R 374931 CDS YP_001292593.1 148827840 5226614 complement(1201539..1204586) 1 NC_009567.1 COG1629 Outer membrane receptor proteins, mostly Fe transport; hemoglobin-binding protein 1204586 5226614 CGSHiGG_06590 Haemophilus influenzae PittGG hemoglobin-binding protein YP_001292593.1 1201539 R 374931 CDS YP_001292594.1 148827841 5226615 1205187..1206932 1 NC_009567.1 COG4988 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components; ABC transporter ATP-binding protein 1206932 5226615 CGSHiGG_06595 Haemophilus influenzae PittGG ABC transporter ATP-binding protein YP_001292594.1 1205187 D 374931 CDS YP_001292595.1 148827842 5226616 1206925..1208583 1 NC_009567.1 COG1132 ABC-type multidrug transport system, ATPase and permease components; shikimate 5-dehydrogenase 1208583 aroE 5226616 aroE Haemophilus influenzae PittGG shikimate 5-dehydrogenase YP_001292595.1 1206925 D 374931 CDS YP_001292596.1 148827843 5226617 1209798..1210016 1 NC_009567.1 COG3074 Uncharacterized protein conserved in bacteria; fructose 1,6-bisphosphatase II 1210016 glpX 5226617 glpX Haemophilus influenzae PittGG fructose 1,6-bisphosphatase II YP_001292596.1 1209798 D 374931 CDS YP_001292597.1 148827844 5226618 1210113..1210553 1 NC_009567.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 1210553 5226618 CGSHiGG_06620 Haemophilus influenzae PittGG flavodoxin YP_001292597.1 1210113 D 374931 CDS YP_001292598.1 148827845 5226619 1210550..1210984 1 NC_009567.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 1210984 5226619 CGSHiGG_06625 Haemophilus influenzae PittGG D-tyrosyl-tRNA(Tyr) deacylase YP_001292598.1 1210550 D 374931 CDS YP_001292599.1 148827846 5226620 complement(1211289..1211765) 1 NC_009567.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 1211765 ispF 5226620 ispF Haemophilus influenzae PittGG 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_001292599.1 1211289 R 374931 CDS YP_001292600.1 148827847 5226621 complement(1211762..1212439) 1 NC_009567.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1212439 ispD 5226621 ispD Haemophilus influenzae PittGG 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_001292600.1 1211762 R 374931 CDS YP_001292601.1 148827848 5226622 complement(1212439..1212717) 1 NC_009567.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB 1212717 ftsB 5226622 ftsB Haemophilus influenzae PittGG cell division protein FtsB YP_001292601.1 1212439 R 374931 CDS YP_001292603.1 148827850 5226624 complement(1212840..1213307) 1 NC_009567.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 1213307 5226624 CGSHiGG_06650 Haemophilus influenzae PittGG xanthine-guanine phosphoribosyltransferase YP_001292603.1 1212840 R 374931 CDS YP_001292604.1 148827851 5226625 1213417..1214871 1 NC_009567.1 COG2195 Di- and tripeptidases; xanthine-guanine phosphoribosyltransferase 1214871 5226625 CGSHiGG_06655 Haemophilus influenzae PittGG xanthine-guanine phosphoribosyltransferase YP_001292604.1 1213417 D 374931 CDS YP_001292605.1 148827852 5226626 complement(1215806..1216246) 1 NC_009567.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; site-specific tyrosine recombinase XerC 1216246 xerC 5226626 xerC Haemophilus influenzae PittGG site-specific tyrosine recombinase XerC YP_001292605.1 1215806 R 374931 CDS YP_001292606.1 148827853 5226627 1216412..1217203 1 NC_009567.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1217203 tpiA 5226627 tpiA Haemophilus influenzae PittGG triosephosphate isomerase YP_001292606.1 1216412 D 374931 CDS YP_001292607.1 148827854 5226628 complement(1217285..1217602) 1 NC_009567.1 COG0607 Rhodanese-related sulfurtransferase; thiosulfate sulfurtransferase GlpE 1217602 5226628 CGSHiGG_06680 Haemophilus influenzae PittGG thiosulfate sulfurtransferase GlpE YP_001292607.1 1217285 R 374931 CDS YP_001292608.1 148827855 5226629 complement(1218512..1219390) 1 NC_009567.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 1219390 5226629 CGSHiGG_06695 Haemophilus influenzae PittGG DNA-binding transcriptional regulator IlvY YP_001292608.1 1218512 R 374931 CDS YP_001292609.1 148827856 5226630 complement(1219551..1219691) 1 NC_009567.1 COG0583 Transcriptional regulator; hypothetical protein 1219691 5226630 CGSHiGG_06700 Haemophilus influenzae PittGG hypothetical protein YP_001292609.1 1219551 R 374931 CDS YP_001292610.1 148827857 5226631 1220043..1221521 1 NC_009567.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 1221521 5226631 CGSHiGG_06705 Haemophilus influenzae PittGG ketol-acid reductoisomerase YP_001292610.1 1220043 D 374931 CDS YP_001292611.1 148827858 5226632 complement(1222923..1224221) 1 NC_009567.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 1224221 5226632 CGSHiGG_06720 Haemophilus influenzae PittGG anaerobic glycerol-3-phosphate dehydrogenase subunit B YP_001292611.1 1222923 R 374931 CDS YP_001292612.1 148827859 5226633 complement(1224211..1225902) 1 NC_009567.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 1225902 glpA 5226633 glpA Haemophilus influenzae PittGG sn-glycerol-3-phosphate dehydrogenase subunit A YP_001292612.1 1224211 R 374931 CDS YP_001292613.1 148827860 5226634 1226195..1227637 1 NC_009567.1 COG2271 Sugar phosphate permease; sn-glycerol-3-phosphate dehydrogenase subunit A 1227637 glpA 5226634 glpA Haemophilus influenzae PittGG sn-glycerol-3-phosphate dehydrogenase subunit A YP_001292613.1 1226195 D 374931 CDS YP_001292614.1 148827861 5226635 1227741..1228835 1 NC_009567.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase 1228835 glpQ 5226635 glpQ Haemophilus influenzae PittGG glycerophosphodiester phosphodiesterase YP_001292614.1 1227741 D 374931 CDS YP_001292615.1 148827862 5226636 1229064..1229858 1 NC_009567.1 COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family); glycerophosphodiester phosphodiesterase 1229858 glpQ 5226636 glpQ Haemophilus influenzae PittGG glycerophosphodiester phosphodiesterase YP_001292615.1 1229064 D 374931 CDS YP_001292616.1 148827863 5226637 1229879..1231390 1 NC_009567.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 1231390 glpK 5226637 glpK Haemophilus influenzae PittGG glycerol kinase YP_001292616.1 1229879 D 374931 CDS YP_001292617.1 148827864 5226638 complement(1231474..1231941) 1 NC_009567.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 1231941 5226638 CGSHiGG_06750 Haemophilus influenzae PittGG xanthine-guanine phosphoribosyltransferase YP_001292617.1 1231474 R 374931 CDS YP_001292618.1 148827865 5226639 1232008..1232100 1 NC_009567.1 COG0584 Glycerophosphoryl diester phosphodiesterase; glycerophosphodiester phosphodiesterase 1232100 5226639 CGSHiGG_06755 Haemophilus influenzae PittGG glycerophosphodiester phosphodiesterase YP_001292618.1 1232008 D 374931 CDS YP_001292619.1 148827866 5226640 1232226..1233050 1 NC_009567.1 COG2503 Predicted secreted acid phosphatase; lipoprotein E 1233050 5226640 CGSHiGG_06760 Haemophilus influenzae PittGG lipoprotein E YP_001292619.1 1232226 D 374931 CDS YP_001292620.1 148827867 5226641 1233229..1233912 1 NC_009567.1 COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; hypothetical protein 1233912 5226641 CGSHiGG_06765 Haemophilus influenzae PittGG hypothetical protein YP_001292620.1 1233229 D 374931 CDS YP_001292621.1 148827868 5226642 complement(1234025..1235002) 1 NC_009567.1 COG0248 Exopolyphosphatase; exopolyphosphatase 1235002 5226642 CGSHiGG_06770 Haemophilus influenzae PittGG exopolyphosphatase YP_001292621.1 1234025 R 374931 CDS YP_001292622.1 148827869 5226643 complement(1235010..1238906) 1 NC_009567.1 COG2911 Uncharacterized protein conserved in bacteria; hypothetical protein 1238906 5226643 CGSHiGG_06775 Haemophilus influenzae PittGG hypothetical protein YP_001292622.1 1235010 R 374931 CDS YP_001292623.1 148827870 5226644 complement(1238916..1240685) 1 NC_009567.1 COG0729 Outer membrane protein; hypothetical protein 1240685 5226644 CGSHiGG_06780 Haemophilus influenzae PittGG hypothetical protein YP_001292623.1 1238916 R 374931 CDS YP_001292624.1 148827871 5226645 complement(1240802..1241374) 1 NC_009567.1 COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2; glycerophosphodiester phosphodiesterase 1241374 glpQ 5226645 glpQ Haemophilus influenzae PittGG glycerophosphodiester phosphodiesterase YP_001292624.1 1240802 R 374931 CDS YP_001292625.1 148827872 5226646 complement(1241454..1241876) 1 NC_009567.1 COG3076 Uncharacterized protein conserved in bacteria; hypothetical protein 1241876 5226646 CGSHiGG_06790 Haemophilus influenzae PittGG hypothetical protein YP_001292625.1 1241454 R 374931 CDS YP_001292626.1 148827873 5226647 1243013..1243762 1 NC_009567.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 1243762 surE 5226647 surE Haemophilus influenzae PittGG stationary phase survival protein SurE YP_001292626.1 1243013 D 374931 CDS YP_001292627.1 148827874 5226648 1243771..1244349 1 NC_009567.1 COG1238 Predicted membrane protein; lipoprotein B 1244349 5226648 CGSHiGG_06810 Haemophilus influenzae PittGG lipoprotein B YP_001292627.1 1243771 D 374931 CDS YP_001292628.1 148827875 5226649 1244358..1244543 1 NC_009567.1 COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases; hypothetical protein 1244543 5226649 CGSHiGG_06815 Haemophilus influenzae PittGG hypothetical protein YP_001292628.1 1244358 D 374931 CDS YP_001292629.1 148827876 5226650 1244567..1245784 1 NC_009567.1 lipoprotein 1245784 5226650 CGSHiGG_06820 Haemophilus influenzae PittGG lipoprotein YP_001292629.1 1244567 D 374931 CDS YP_001292630.1 148827877 5226651 1247652..1248884 1 NC_009567.1 COG0814 Amino acid permeases; stationary phase survival protein SurE 1248884 surE 5226651 surE Haemophilus influenzae PittGG stationary phase survival protein SurE YP_001292630.1 1247652 D 374931 CDS YP_001292631.1 148827878 5226652 1253284..1255143 1 NC_009567.1 COG3276 Selenocysteine-specific translation elongation factor; selenocysteine-specific elongation factor 1255143 5226652 CGSHiGG_06865 Haemophilus influenzae PittGG selenocysteine-specific elongation factor YP_001292631.1 1253284 D 374931 CDS YP_001292632.1 148827879 5226653 1255162..1256016 1 NC_009567.1 COG0642 Signal transduction histidine kinase; hypothetical protein 1256016 5226653 CGSHiGG_06870 Haemophilus influenzae PittGG hypothetical protein YP_001292632.1 1255162 D 374931 CDS YP_001292633.1 148827880 5226654 complement(1256070..1259264) 1 NC_009567.1 COG1629 Outer membrane receptor proteins, mostly Fe transport; selenocysteine synthase 1259264 5226654 CGSHiGG_06875 Haemophilus influenzae PittGG selenocysteine synthase YP_001292633.1 1256070 R 374931 CDS YP_001292634.1 148827881 5226655 1259565..1260863 1 NC_009567.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 1260863 tig 5226655 tig Haemophilus influenzae PittGG trigger factor YP_001292634.1 1259565 D 374931 CDS YP_001292635.1 148827882 5226656 1260986..1261567 1 NC_009567.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 1261567 clpP 5226656 clpP Haemophilus influenzae PittGG ATP-dependent Clp protease proteolytic subunit YP_001292635.1 1260986 D 374931 CDS YP_001292636.1 148827883 5226657 1261577..1262812 1 NC_009567.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 1262812 clpX 5226657 clpX Haemophilus influenzae PittGG ATP-dependent protease ATP-binding subunit ClpX YP_001292636.1 1261577 D 374931 CDS YP_001292637.1 148827884 5226658 1262956..1263372 1 NC_009567.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 1263372 secE 5226658 secE Haemophilus influenzae PittGG preprotein translocase subunit SecE YP_001292637.1 1262956 D 374931 CDS YP_001292638.1 148827885 5226659 1263374..1263931 1 NC_009567.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 1263931 nusG 5226659 nusG Haemophilus influenzae PittGG transcription antitermination protein NusG YP_001292638.1 1263374 D 374931 CDS YP_001292639.1 148827886 5226660 1264029..1264781 1 NC_009567.1 COG2853 Surface lipoprotein; lipoprotein 1264781 5226660 CGSHiGG_06905 Haemophilus influenzae PittGG lipoprotein YP_001292639.1 1264029 D 374931 CDS YP_001292640.1 148827887 5226661 1264838..1265227 1 NC_009567.1 COG0251 Putative translation initiation inhibitor, yjgF family; transcription antitermination protein NusG 1265227 nusG 5226661 nusG Haemophilus influenzae PittGG transcription antitermination protein NusG YP_001292640.1 1264838 D 374931 CDS YP_001292641.1 148827888 5226662 1265394..1266245 1 NC_009567.1 putative metalloprotease; heat shock protein HtpX 1266245 5226662 CGSHiGG_06915 Haemophilus influenzae PittGG heat shock protein HtpX YP_001292641.1 1265394 D 374931 CDS YP_001292642.1 148827889 5226663 complement(1266287..1266526) 1 NC_009567.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 1266526 5226663 CGSHiGG_06920 Haemophilus influenzae PittGG sulfur transfer protein SirA YP_001292642.1 1266287 R 374931 CDS YP_001292643.1 148827890 5226664 1266629..1267261 1 NC_009567.1 COG1739 Uncharacterized conserved protein; hypothetical protein 1267261 5226664 CGSHiGG_06925 Haemophilus influenzae PittGG hypothetical protein YP_001292643.1 1266629 D 374931 CDS YP_001292644.1 148827891 5226665 1267264..1268727 1 NC_009567.1 COG0168 Trk-type K+ transport systems, membrane components; Trk system potassium uptake protein TrkH 1268727 5226665 CGSHiGG_06930 Haemophilus influenzae PittGG Trk system potassium uptake protein TrkH YP_001292644.1 1267264 D 374931 CDS YP_001292645.1 148827892 5226668 1275476..1275742 1 NC_009567.1 phosphate-starvation-inducible protein PsiE 1275742 5226668 CGSHiGG_06935 Haemophilus influenzae PittGG phosphate-starvation-inducible protein PsiE YP_001292645.1 1275476 D 374931 CDS YP_001292646.1 148827893 5226669 1275766..1275855 1 NC_009567.1 COG3223 Predicted membrane protein; phosphate-starvation-inducible protein PsiE 1275855 5226669 CGSHiGG_06940 Haemophilus influenzae PittGG phosphate-starvation-inducible protein PsiE YP_001292646.1 1275766 D 374931 CDS YP_001292647.1 148827894 5226670 complement(1275923..1277209) 1 NC_009567.1 COG3071 Uncharacterized enzyme of heme biosynthesis; heme-biosynthesis protein HemY 1277209 5226670 CGSHiGG_06945 Haemophilus influenzae PittGG heme-biosynthesis protein HemY YP_001292647.1 1275923 R 374931 CDS YP_001292648.1 148827895 5226671 complement(1277220..1278431) 1 NC_009567.1 COG2959 Uncharacterized enzyme of heme biosynthesis; cell developmental protein SirA 1278431 5226671 CGSHiGG_06950 Haemophilus influenzae PittGG cell developmental protein SirA YP_001292648.1 1277220 R 374931 CDS YP_001292649.1 148827896 5226672 1278736..1281267 1 NC_009567.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 1281267 cyaA 5226672 cyaA Haemophilus influenzae PittGG adenylate cyclase YP_001292649.1 1278736 D 374931 CDS YP_001292650.1 148827897 5226673 1282361..1283164 1 NC_009567.1 catalyzes the O-acetylation of serine; serine acetyltransferase 1283164 cysE 5226673 cysE Haemophilus influenzae PittGG serine acetyltransferase YP_001292650.1 1282361 D 374931 CDS YP_001292651.1 148827898 5226674 1283174..1283989 1 NC_009567.1 catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 1283989 5226674 CGSHiGG_06975 Haemophilus influenzae PittGG shikimate 5-dehydrogenase YP_001292651.1 1283174 D 374931 CDS YP_001292652.1 148827899 5226675 1284128..1285513 1 NC_009567.1 COG0471 Di- and tricarboxylate transporters; putative di- and tricarboxylate transporter 1285513 5226675 CGSHiGG_06980 Haemophilus influenzae PittGG putative di- and tricarboxylate transporter YP_001292652.1 1284128 D 374931 CDS YP_001292653.1 148827900 5226676 complement(1285651..1286499) 1 NC_009567.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 1286499 5226676 CGSHiGG_06985 Haemophilus influenzae PittGG bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_001292653.1 1285651 R 374931 CDS YP_001292654.1 148827901 5226677 complement(1288352..1289002) 1 NC_009567.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 1289002 5226677 CGSHiGG_07000 Haemophilus influenzae PittGG L-fuculose phosphate aldolase YP_001292654.1 1288352 R 374931 CDS YP_001292655.1 148827902 5226681 complement(1289022..1289456) 1 NC_009567.1 COG4154 Fucose dissimilation pathway protein FucU; L-fuculose phosphate aldolase 1289456 5226681 CGSHiGG_07005 Haemophilus influenzae PittGG L-fuculose phosphate aldolase YP_001292655.1 1289022 R 374931 CDS YP_001292656.1 148827903 5226682 complement(1291105..1292721) 1 NC_009567.1 COG2407 L-fucose isomerase and related proteins; L-fucose isomerase 1292721 5226682 CGSHiGG_07020 Haemophilus influenzae PittGG L-fucose isomerase YP_001292656.1 1291105 R 374931 CDS YP_001292657.1 148827904 5226684 complement(1292962..1293711) 1 NC_009567.1 COG1349 Transcriptional regulators of sugar metabolism; L-fucose isomerase 1293711 fucI 5226684 fucI Haemophilus influenzae PittGG L-fucose isomerase YP_001292657.1 1292962 R 374931 CDS YP_001292658.1 148827905 5226687 1296684..1297343 1 NC_009567.1 COG0564 Pseudouridylate synthases, 23S RNA-specific; hypothetical protein 1297343 5226687 CGSHiGG_07040 Haemophilus influenzae PittGG hypothetical protein YP_001292658.1 1296684 D 374931 CDS YP_001292659.1 148827906 5226688 1297370..1297948 1 NC_009567.1 COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid); hypothetical protein 1297948 5226688 CGSHiGG_07045 Haemophilus influenzae PittGG hypothetical protein YP_001292659.1 1297370 D 374931 CDS YP_001292660.1 148827907 5226689 1297978..1298745 1 NC_009567.1 COG1349 Transcriptional regulators of sugar metabolism; glycerol-3-phosphate regulon repressor 1298745 5226689 CGSHiGG_07050 Haemophilus influenzae PittGG glycerol-3-phosphate regulon repressor YP_001292660.1 1297978 D 374931 CDS YP_001292661.1 148827908 5226690 complement(1299047..1299868) 1 NC_009567.1 COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen; putative D-methionine-binding lipoprotein MetQ 1299868 5226690 CGSHiGG_07055 Haemophilus influenzae PittGG putative D-methionine-binding lipoprotein MetQ YP_001292661.1 1299047 R 374931 CDS YP_001292662.1 148827909 5226691 complement(1299907..1300596) 1 NC_009567.1 COG2011 ABC-type metal ion transport system, permease component; ATP-dependent helicase HepA 1300596 5226691 CGSHiGG_07060 Haemophilus influenzae PittGG ATP-dependent helicase HepA YP_001292662.1 1299907 R 374931 CDS YP_001292663.1 148827910 5226692 complement(1300586..1301623) 1 NC_009567.1 part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit 1301623 metN 5226692 metN Haemophilus influenzae PittGG DL-methionine transporter ATP-binding subunit YP_001292663.1 1300586 R 374931 CDS YP_001292664.1 148827911 5226693 1301800..1302354 1 NC_009567.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 1302354 5226693 CGSHiGG_07070 Haemophilus influenzae PittGG D,D-heptose 1,7-bisphosphate phosphatase YP_001292664.1 1301800 D 374931 CDS YP_001292665.1 148827912 5226700 1308363..1308923 1 NC_009567.1 hypothetical protein 1308923 5226700 CGSHiGG_07075 Haemophilus influenzae PittGG hypothetical protein YP_001292665.1 1308363 D 374931 CDS YP_001292666.1 148827913 5226701 1308927..1309367 1 NC_009567.1 COG3078 Uncharacterized protein conserved in bacteria; hypothetical protein 1309367 5226701 CGSHiGG_07080 Haemophilus influenzae PittGG hypothetical protein YP_001292666.1 1308927 D 374931 CDS YP_001292667.1 148827914 5226702 complement(1309429..1310055) 1 NC_009567.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; nitrate/nitrite response regulator protein 1310055 5226702 CGSHiGG_07085 Haemophilus influenzae PittGG nitrate/nitrite response regulator protein YP_001292667.1 1309429 R 374931 CDS YP_001292668.1 148827915 5226703 complement(1310157..1311509) 1 NC_009567.1 diaminopimelate decarboxylase 1311509 5226703 CGSHiGG_07090 Haemophilus influenzae PittGG diaminopimelate decarboxylase YP_001292668.1 1310157 R 374931 CDS YP_001292669.1 148827916 5226704 complement(1311557..1311673) 1 NC_009567.1 COG0019 Diaminopimelate decarboxylase; hypothetical protein 1311673 5226704 CGSHiGG_07095 Haemophilus influenzae PittGG hypothetical protein YP_001292669.1 1311557 R 374931 CDS YP_001292670.1 148827917 5226705 1311770..1312075 1 NC_009567.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 1312075 cyaY 5226705 cyaY Haemophilus influenzae PittGG frataxin-like protein YP_001292670.1 1311770 D 374931 CDS YP_001292671.1 148827918 5226706 1312077..1313936 1 NC_009567.1 COG0514 Superfamily II DNA helicase; frataxin-like protein 1313936 cyaY 5226706 cyaY Haemophilus influenzae PittGG frataxin-like protein YP_001292671.1 1312077 D 374931 CDS YP_001292672.1 148827919 5226707 1314021..1315739 1 NC_009567.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 1315739 5226707 CGSHiGG_07110 Haemophilus influenzae PittGG prolyl-tRNA synthetase YP_001292672.1 1314021 D 374931 CDS YP_001292673.1 148827920 5226708 complement(1318294..1318785) 1 NC_009567.1 COG2132 Putative multicopper oxidases; hypothetical protein 1318785 5226708 CGSHiGG_07125 Haemophilus influenzae PittGG hypothetical protein YP_001292673.1 1318294 R 374931 CDS YP_001292674.1 148827921 5226709 complement(1318791..1319702) 1 NC_009567.1 COG2132 Putative multicopper oxidases; hypothetical protein 1319702 5226709 CGSHiGG_07130 Haemophilus influenzae PittGG hypothetical protein YP_001292674.1 1318791 R 374931 CDS YP_001292675.1 148827922 5226710 complement(1319704..1320426) 1 NC_009567.1 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; organic solvent tolerance protein 1320426 5226710 CGSHiGG_07135 Haemophilus influenzae PittGG organic solvent tolerance protein YP_001292675.1 1319704 R 374931 CDS YP_001292676.1 148827923 5226711 1320512..1321225 1 NC_009567.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 1321225 5226711 CGSHiGG_07140 Haemophilus influenzae PittGG UDP-2,3-diacylglucosamine hydrolase YP_001292676.1 1320512 D 374931 CDS YP_001292677.1 148827924 5226712 complement(1321358..1321453) 1 NC_009567.1 COG2908 Uncharacterized protein conserved in bacteria; hypothetical protein 1321453 5226712 CGSHiGG_07145 Haemophilus influenzae PittGG hypothetical protein YP_001292677.1 1321358 R 374931 CDS YP_001292678.1 148827925 5226713 complement(1321455..1322981) 1 NC_009567.1 COG0733 Na+-dependent transporters of the SNF family; putative sodium-dependent transporter 1322981 5226713 CGSHiGG_07150 Haemophilus influenzae PittGG putative sodium-dependent transporter YP_001292678.1 1321455 R 374931 CDS YP_001292679.1 148827926 5226716 1323226..1323852 1 NC_009567.1 UDP-2,3-diacylglucosamine hydrolase 1323852 5226716 CGSHiGG_07155 Haemophilus influenzae PittGG UDP-2,3-diacylglucosamine hydrolase YP_001292679.1 1323226 D 374931 CDS YP_001292680.1 148827927 5226717 1323862..1324677 1 NC_009567.1 COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; hypothetical protein 1324677 5226717 CGSHiGG_07160 Haemophilus influenzae PittGG hypothetical protein YP_001292680.1 1323862 D 374931 CDS YP_001292681.1 148827928 5226718 1324715..1326553 1 NC_009567.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 1326553 5226718 CGSHiGG_07165 Haemophilus influenzae PittGG dihydroxy-acid dehydratase YP_001292681.1 1324715 D 374931 CDS YP_001292682.1 148827929 5226719 complement(1326832..1326960) 1 NC_009567.1 hypothetical protein 1326960 5226719 CGSHiGG_07170 Haemophilus influenzae PittGG hypothetical protein YP_001292682.1 1326832 R 374931 CDS YP_001292683.1 148827930 5226720 complement(1328210..1331689) 1 NC_009567.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 1331689 dnaE 5226720 dnaE Haemophilus influenzae PittGG DNA polymerase III subunit alpha YP_001292683.1 1328210 R 374931 CDS YP_001292684.1 148827931 5226721 1331928..1333580 1 NC_009567.1 phosphomannomutase 1333580 5226721 CGSHiGG_07190 Haemophilus influenzae PittGG phosphomannomutase YP_001292684.1 1331928 D 374931 CDS YP_001292686.1 148827933 5226723 1333729..1334124 1 NC_009567.1 COG0702 Predicted nucleoside-diphosphate-sugar epimerases; DNA polymerase III subunit alpha 1334124 dnaE 5226723 dnaE Haemophilus influenzae PittGG DNA polymerase III subunit alpha YP_001292686.1 1333729 D 374931 CDS YP_001292687.1 148827934 5226724 complement(1334121..1334627) 1 NC_009567.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 1334627 5226724 CGSHiGG_07205 Haemophilus influenzae PittGG preprotein translocase subunit SecB YP_001292687.1 1334121 R 374931 CDS YP_001292688.1 148827935 5226725 complement(1334641..1335087) 1 NC_009567.1 COG0607 Rhodanese-related sulfurtransferase; export protein SecB 1335087 5226725 CGSHiGG_07210 Haemophilus influenzae PittGG export protein SecB YP_001292688.1 1334641 R 374931 CDS YP_001292689.1 148827936 5226726 1335314..1336363 1 NC_009567.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II 1336363 ansB 5226726 ansB Haemophilus influenzae PittGG L-asparaginase II YP_001292689.1 1335314 D 374931 CDS YP_001292690.1 148827937 5226727 1336520..1337842 1 NC_009567.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 1337842 5226727 CGSHiGG_07220 Haemophilus influenzae PittGG anaerobic C4-dicarboxylate transporter YP_001292690.1 1336520 D 374931 CDS YP_001292691.1 148827938 5226728 complement(1339460..1341892) 1 NC_009567.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 1341892 5226728 CGSHiGG_07235 Haemophilus influenzae PittGG glycerol-3-phosphate acyltransferase YP_001292691.1 1339460 R 374931 CDS YP_001292692.1 148827939 5226729 1342147..1342770 1 NC_009567.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 1342770 5226729 CGSHiGG_07240 Haemophilus influenzae PittGG LexA repressor YP_001292692.1 1342147 D 374931 CDS YP_001292693.1 148827940 5226730 1342913..1343737 1 NC_009567.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 1343737 dapF 5226730 dapF Haemophilus influenzae PittGG diaminopimelate epimerase YP_001292693.1 1342913 D 374931 CDS YP_001292694.1 148827941 5226731 complement(1343957..1344454) 1 NC_009567.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1344454 tpx 5226731 tpx Haemophilus influenzae PittGG thiol peroxidase YP_001292694.1 1343957 R 374931 CDS YP_001292695.1 148827942 5226732 1345102..1348995 1 NC_009567.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 1348995 5226732 CGSHiGG_07255 Haemophilus influenzae PittGG phosphoribosylformylglycinamidine synthase YP_001292695.1 1345102 D 374931 CDS YP_001292696.1 148827943 5226733 1349191..1349496 1 NC_009567.1 COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain; hypothetical protein 1349496 5226733 CGSHiGG_07260 Haemophilus influenzae PittGG hypothetical protein YP_001292696.1 1349191 D 374931 CDS YP_001292697.1 148827944 5226734 1349510..1350253 1 NC_009567.1 COG3306 Glycosyltransferase involved in LPS biosynthesis; UDP-glucose--lipooligosaccharide glucosyltransferase 1350253 5226734 CGSHiGG_07265 Haemophilus influenzae PittGG UDP-glucose--lipooligosaccharide glucosyltransferase YP_001292697.1 1349510 D 374931 CDS YP_001292698.1 148827945 5226735 complement(1350314..1351156) 1 NC_009567.1 COG2861 Uncharacterized protein conserved in bacteria; hypothetical protein 1351156 5226735 CGSHiGG_07270 Haemophilus influenzae PittGG hypothetical protein YP_001292698.1 1350314 R 374931 CDS YP_001292699.1 148827946 5226736 complement(1351156..1352385) 1 NC_009567.1 COG4942 Membrane-bound metallopeptidase; membrane-bound metallopeptidase 1352385 5226736 CGSHiGG_07275 Haemophilus influenzae PittGG membrane-bound metallopeptidase YP_001292699.1 1351156 R 374931 CDS YP_001292700.1 148827947 5226737 1352561..1353244 1 NC_009567.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 1353244 5226737 CGSHiGG_07280 Haemophilus influenzae PittGG phosphoglyceromutase YP_001292700.1 1352561 D 374931 CDS YP_001292701.1 148827948 5226738 complement(1353322..1353534) 1 NC_009567.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1353534 rpmE 5226738 rpmE Haemophilus influenzae PittGG 50S ribosomal protein L31 YP_001292701.1 1353322 R 374931 CDS YP_001292702.1 148827949 5226739 1353711..1354847 1 NC_009567.1 COG1194 A/G-specific DNA glycosylase; 50S ribosomal protein L31 1354847 rpmE 5226739 rpmE Haemophilus influenzae PittGG 50S ribosomal protein L31 YP_001292702.1 1353711 D 374931 CDS YP_001292703.1 148827950 5226740 1354825..1355097 1 NC_009567.1 COG2924 Fe-S cluster protector protein; hypothetical protein 1355097 5226740 CGSHiGG_07295 Haemophilus influenzae PittGG hypothetical protein YP_001292703.1 1354825 D 374931 CDS YP_001292704.1 148827951 5226741 1355112..1356185 1 NC_009567.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 1356185 mltC 5226741 mltC Haemophilus influenzae PittGG murein transglycosylase C YP_001292704.1 1355112 D 374931 CDS YP_001292705.1 148827952 5226742 complement(1356797..1357477) 1 NC_009567.1 COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases; murein transglycosylase C 1357477 mltC 5226742 mltC Haemophilus influenzae PittGG murein transglycosylase C YP_001292705.1 1356797 R 374931 CDS YP_001292706.1 148827953 5226743 complement(1357474..1358697) 1 NC_009567.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 1358697 5226743 CGSHiGG_07310 Haemophilus influenzae PittGG nicotinamide-nucleotide adenylyltransferase YP_001292706.1 1357474 R 374931 CDS YP_001292707.1 148827954 5226744 1358958..1359605 1 NC_009567.1 DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase 1359605 ribB 5226744 ribB Haemophilus influenzae PittGG 3,4-dihydroxy-2-butanone 4-phosphate synthase YP_001292707.1 1358958 D 374931 CDS YP_001292708.1 148827955 5226745 1359637..1360350 1 NC_009567.1 COG3306 Glycosyltransferase involved in LPS biosynthesis; lipooligosaccharide biosynthesis protein 1360350 5226745 CGSHiGG_07320 Haemophilus influenzae PittGG lipooligosaccharide biosynthesis protein YP_001292708.1 1359637 D 374931 CDS YP_001292709.1 148827956 5226746 complement(1360518..1361000) 1 NC_009567.1 COG0219 Predicted rRNA methylase (SpoU class); putative RNA methyltransferase 1361000 5226746 CGSHiGG_07325 Haemophilus influenzae PittGG putative RNA methyltransferase YP_001292709.1 1360518 R 374931 CDS YP_001292710.1 148827957 5226747 complement(1361011..1361592) 1 NC_009567.1 COG0742 N6-adenine-specific methylase; hypothetical protein 1361592 5226747 CGSHiGG_07330 Haemophilus influenzae PittGG hypothetical protein YP_001292710.1 1361011 R 374931 CDS YP_001292711.1 148827958 5226748 1361689..1362891 1 NC_009567.1 COG0552 Signal recognition particle GTPase; cell division protein FtsY 1362891 5226748 CGSHiGG_07335 Haemophilus influenzae PittGG cell division protein FtsY YP_001292711.1 1361689 D 374931 CDS YP_001292712.1 148827959 5226749 1362910..1363566 1 NC_009567.1 COG2884 Predicted ATPase involved in cell division; 3,4-dihydroxy-2-butanone 4-phosphate synthase 1363566 ribB 5226749 ribB Haemophilus influenzae PittGG 3,4-dihydroxy-2-butanone 4-phosphate synthase YP_001292712.1 1362910 D 374931 CDS YP_001292713.1 148827960 5226750 1363576..1364508 1 NC_009567.1 putative ABC transporter, membrane protein; cell division protein FtsX 1364508 ftsX 5226750 ftsX Haemophilus influenzae PittGG cell division protein FtsX YP_001292713.1 1363576 D 374931 CDS YP_001292714.1 148827961 5226751 complement(1364603..1365784) 1 NC_009567.1 COG0183 Acetyl-CoA acetyltransferase; acetyl-CoA acetyltransferase 1365784 5226751 CGSHiGG_07350 Haemophilus influenzae PittGG acetyl-CoA acetyltransferase YP_001292714.1 1364603 R 374931 CDS YP_001292715.1 148827962 5226752 complement(1367146..1367811) 1 NC_009567.1 COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit; membrane component of ABC transporter FtsEX 1367811 ftsX 5226752 ftsX Haemophilus influenzae PittGG membrane component of ABC transporter FtsEX YP_001292715.1 1367146 R 374931 CDS YP_001292716.1 148827963 5226753 complement(1367822..1368475) 1 NC_009567.1 COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit; acetyl-CoA:acetoacetyl-CoA transferase subunit alpha 1368475 5226753 CGSHiGG_07370 Haemophilus influenzae PittGG acetyl-CoA:acetoacetyl-CoA transferase subunit alpha YP_001292716.1 1367822 R 374931 CDS YP_001292717.1 148827964 5226754 1368722..1369627 1 NC_009567.1 COG0583 Transcriptional regulator; putative HTH-type transcriptional regulator 1369627 5226754 CGSHiGG_07375 Haemophilus influenzae PittGG putative HTH-type transcriptional regulator YP_001292717.1 1368722 D 374931 CDS YP_001292718.1 148827965 5226755 1369863..1370174 1 NC_009567.1 COG0051 Ribosomal protein S10; acetyl-CoA:acetoacetyl-CoA transferase subunit alpha 1370174 5226755 CGSHiGG_07380 Haemophilus influenzae PittGG acetyl-CoA:acetoacetyl-CoA transferase subunit alpha YP_001292718.1 1369863 D 374931 CDS YP_001292719.1 148827966 5226756 1370191..1370817 1 NC_009567.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 1370817 rplC 5226756 rplC Haemophilus influenzae PittGG 50S ribosomal protein L3 YP_001292719.1 1370191 D 374931 CDS YP_001292720.1 148827967 5226757 1370833..1371435 1 NC_009567.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 1371435 rplD 5226757 rplD Haemophilus influenzae PittGG 50S ribosomal protein L4 YP_001292720.1 1370833 D 374931 CDS YP_001292721.1 148827968 5226758 1371432..1371731 1 NC_009567.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 1371731 rplW 5226758 rplW Haemophilus influenzae PittGG 50S ribosomal protein L23 YP_001292721.1 1371432 D 374931 CDS YP_001292722.1 148827969 5226759 1371749..1372570 1 NC_009567.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 1372570 rplB 5226759 rplB Haemophilus influenzae PittGG 50S ribosomal protein L2 YP_001292722.1 1371749 D 374931 CDS YP_001292723.1 148827970 5226760 1372596..1372871 1 NC_009567.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 1372871 rpsS 5226760 rpsS Haemophilus influenzae PittGG 30S ribosomal protein S19 YP_001292723.1 1372596 D 374931 CDS YP_001292724.1 148827971 5226761 1372883..1373215 1 NC_009567.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 1373215 rplV 5226761 rplV Haemophilus influenzae PittGG 50S ribosomal protein L22 YP_001292724.1 1372883 D 374931 CDS YP_001292725.1 148827972 5226762 1373233..1373940 1 NC_009567.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 1373940 rpsC 5226762 rpsC Haemophilus influenzae PittGG 30S ribosomal protein S3 YP_001292725.1 1373233 D 374931 CDS YP_001292726.1 148827973 5226763 1373954..1374364 1 NC_009567.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 1374364 rplP 5226763 rplP Haemophilus influenzae PittGG 50S ribosomal protein L16 YP_001292726.1 1373954 D 374931 CDS YP_001292727.1 148827974 5226764 1374364..1374555 1 NC_009567.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 1374555 5226764 CGSHiGG_07425 Haemophilus influenzae PittGG 50S ribosomal protein L29 YP_001292727.1 1374364 D 374931 CDS YP_001292728.1 148827975 5226765 1374555..1374812 1 NC_009567.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 1374812 rpsQ 5226765 rpsQ Haemophilus influenzae PittGG 30S ribosomal protein S17 YP_001292728.1 1374555 D 374931 CDS YP_001292729.1 148827976 5226766 1375040..1375825 1 NC_009567.1 COG0186 Ribosomal protein S17; 30S ribosomal protein S17 1375825 rpsQ 5226766 rpsQ Haemophilus influenzae PittGG 30S ribosomal protein S17 YP_001292729.1 1375040 D 374931 CDS YP_001292730.1 148827977 5226770 1376105..1376476 1 NC_009567.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 1376476 rplN 5226770 rplN Haemophilus influenzae PittGG 50S ribosomal protein L14 YP_001292730.1 1376105 D 374931 CDS YP_001292731.1 148827978 5226771 1376487..1376798 1 NC_009567.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 1376798 rplX 5226771 rplX Haemophilus influenzae PittGG 50S ribosomal protein L24 YP_001292731.1 1376487 D 374931 CDS YP_001292732.1 148827979 5226772 1376816..1377355 1 NC_009567.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 1377355 rplE 5226772 rplE Haemophilus influenzae PittGG 50S ribosomal protein L5 YP_001292732.1 1376816 D 374931 CDS YP_001292733.1 148827980 5226773 1377367..1377672 1 NC_009567.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 1377672 rpsN 5226773 rpsN Haemophilus influenzae PittGG 30S ribosomal protein S14 YP_001292733.1 1377367 D 374931 CDS YP_001292734.1 148827981 5226774 1377709..1378101 1 NC_009567.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 1378101 rpsH 5226774 rpsH Haemophilus influenzae PittGG 30S ribosomal protein S8 YP_001292734.1 1377709 D 374931 CDS YP_001292735.1 148827982 5226775 1378117..1378650 1 NC_009567.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 1378650 rplF 5226775 rplF Haemophilus influenzae PittGG 50S ribosomal protein L6 YP_001292735.1 1378117 D 374931 CDS YP_001292736.1 148827983 5226776 1378664..1379017 1 NC_009567.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 1379017 rplR 5226776 rplR Haemophilus influenzae PittGG 50S ribosomal protein L18 YP_001292736.1 1378664 D 374931 CDS YP_001292737.1 148827984 5226777 1379032..1379532 1 NC_009567.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 1379532 rpsE 5226777 rpsE Haemophilus influenzae PittGG 30S ribosomal protein S5 YP_001292737.1 1379032 D 374931 CDS YP_001292738.1 148827985 5226778 1379539..1379718 1 NC_009567.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 1379718 rpmD 5226778 rpmD Haemophilus influenzae PittGG 50S ribosomal protein L30 YP_001292738.1 1379539 D 374931 CDS YP_001292739.1 148827986 5226779 1379722..1380156 1 NC_009567.1 late assembly protein; 50S ribosomal protein L15 1380156 rplO 5226779 rplO Haemophilus influenzae PittGG 50S ribosomal protein L15 YP_001292739.1 1379722 D 374931 CDS YP_001292740.1 148827987 5226780 1380164..1381489 1 NC_009567.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 1381489 secY 5226780 secY Haemophilus influenzae PittGG preprotein translocase subunit SecY YP_001292740.1 1380164 D 374931 CDS YP_001292741.1 148827988 5226781 1381771..1382127 1 NC_009567.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 1382127 rpsM 5226781 rpsM Haemophilus influenzae PittGG 30S ribosomal protein S13 YP_001292741.1 1381771 D 374931 CDS YP_001292742.1 148827989 5226782 1382394..1382531 1 NC_009567.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 1382531 rpsM 5226782 rpsM Haemophilus influenzae PittGG 30S ribosomal protein S11 YP_001292742.1 1382394 D 374931 CDS YP_001292743.1 148827990 5226783 1382559..1383179 1 NC_009567.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 1383179 rpsD 5226783 rpsD Haemophilus influenzae PittGG 30S ribosomal protein S4 YP_001292743.1 1382559 D 374931 CDS YP_001292744.1 148827991 5226784 1383211..1384197 1 NC_009567.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 1384197 5226784 CGSHiGG_07510 Haemophilus influenzae PittGG DNA-directed RNA polymerase subunit alpha YP_001292744.1 1383211 D 374931 CDS YP_001292745.1 148827992 5226785 1384238..1384624 1 NC_009567.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 1384624 rplQ 5226785 rplQ Haemophilus influenzae PittGG 50S ribosomal protein L17 YP_001292745.1 1384238 D 374931 CDS YP_001292746.1 148827993 5226786 complement(1384751..1385017) 1 NC_009567.1 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases; cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase 1385017 5226786 CGSHiGG_07520 Haemophilus influenzae PittGG cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase YP_001292746.1 1384751 R 374931 CDS YP_001292747.1 148827994 5226787 1385213..1386022 1 NC_009567.1 COG0730 Predicted permeases; 50S ribosomal protein L17 1386022 rplQ 5226787 rplQ Haemophilus influenzae PittGG 50S ribosomal protein L17 YP_001292747.1 1385213 D 374931 CDS YP_001292748.1 148827995 5226788 complement(1386054..1387247) 1 NC_009567.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1387247 5226788 CGSHiGG_07530 Haemophilus influenzae PittGG 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_001292748.1 1386054 R 374931 CDS YP_001292749.1 148827996 5226789 complement(1387356..1387913) 1 NC_009567.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 1387913 frr 5226789 frr Haemophilus influenzae PittGG ribosome recycling factor YP_001292749.1 1387356 R 374931 CDS YP_001292750.1 148827997 5226790 complement(1388062..1389678) 1 NC_009567.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 1389678 5226790 CGSHiGG_07540 Haemophilus influenzae PittGG phosphoenolpyruvate carboxykinase YP_001292750.1 1388062 R 374931 CDS YP_001292751.1 148827998 5226791 complement(1389851..1390732) 1 NC_009567.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 1390732 hslO 5226791 hslO Haemophilus influenzae PittGG Hsp33-like chaperonin YP_001292751.1 1389851 R 374931 CDS YP_001292752.1 148827999 5226792 complement(1390877..1392250) 1 NC_009567.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 1392250 5226792 CGSHiGG_07550 Haemophilus influenzae PittGG argininosuccinate lyase YP_001292752.1 1390877 R 374931 CDS YP_001292753.1 148828000 5226793 complement(1392385..1393272) 1 NC_009567.1 COG1210 UDP-glucose pyrophosphorylase; argininosuccinate lyase 1393272 5226793 CGSHiGG_07555 Haemophilus influenzae PittGG argininosuccinate lyase YP_001292753.1 1392385 R 374931 CDS YP_001292754.1 148828001 5226794 complement(1393294..1393485) 1 NC_009567.1 affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator 1393485 5226794 CGSHiGG_07560 Haemophilus influenzae PittGG carbon storage regulator YP_001292754.1 1393294 R 374931 CDS YP_001292755.1 148828002 5226795 complement(1393563..1396187) 1 NC_009567.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1396187 alaS 5226795 alaS Haemophilus influenzae PittGG alanyl-tRNA synthetase YP_001292755.1 1393563 R 374931 CDS YP_001292756.1 148828003 5226796 complement(1396375..1396800) 1 NC_009567.1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins; universal stress protein A 1396800 5226796 CGSHiGG_07570 Haemophilus influenzae PittGG universal stress protein A YP_001292756.1 1396375 R 374931 CDS YP_001292757.1 148828004 5226797 complement(1398205..1398753) 1 NC_009567.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein 1398753 5226797 CGSHiGG_07585 Haemophilus influenzae PittGG hypothetical protein YP_001292757.1 1398205 R 374931 CDS YP_001292758.1 148828005 5226798 complement(1398924..1399946) 1 NC_009567.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase 1399946 galM 5226798 galM Haemophilus influenzae PittGG aldose 1-epimerase YP_001292758.1 1398924 R 374931 CDS YP_001292759.1 148828006 5226799 complement(1399956..1401110) 1 NC_009567.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 1401110 5226799 CGSHiGG_07595 Haemophilus influenzae PittGG galactokinase YP_001292759.1 1399956 R 374931 CDS YP_001292760.1 148828007 5226800 complement(1401187..1402236) 1 NC_009567.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 1402236 5226800 CGSHiGG_07600 Haemophilus influenzae PittGG galactose-1-phosphate uridylyltransferase YP_001292760.1 1401187 R 374931 CDS YP_001292761.1 148828008 5226801 1402445..1403446 1 NC_009567.1 COG1609 Transcriptional regulators; galactose operon repressor 1403446 5226801 CGSHiGG_07605 Haemophilus influenzae PittGG galactose operon repressor YP_001292761.1 1402445 D 374931 CDS YP_001292762.1 148828009 5226802 1403621..1404616 1 NC_009567.1 COG1879 ABC-type sugar transport system, periplasmic component; galactose-1-phosphate uridylyltransferase 1404616 5226802 CGSHiGG_07610 Haemophilus influenzae PittGG galactose-1-phosphate uridylyltransferase YP_001292762.1 1403621 D 374931 CDS YP_001292763.1 148828010 5226803 1404681..1406201 1 NC_009567.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein 1406201 5226803 CGSHiGG_07615 Haemophilus influenzae PittGG galactose/methyl galaxtoside transporter ATP-binding protein YP_001292763.1 1404681 D 374931 CDS YP_001292764.1 148828011 5226804 1406219..1407229 1 NC_009567.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane component 1407229 mglC 5226804 mglC Haemophilus influenzae PittGG beta-methylgalactoside transporter inner membrane component YP_001292764.1 1406219 D 374931 CDS YP_001292765.1 148828012 5226805 1407375..1408109 1 NC_009567.1 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; beta-methylgalactoside transporter inner membrane component 1408109 mglC 5226805 mglC Haemophilus influenzae PittGG beta-methylgalactoside transporter inner membrane component YP_001292765.1 1407375 D 374931 CDS YP_001292766.1 148828013 5227430 1408115..1408672 1 NC_009567.1 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 1408672 5227430 CGSHiGG_07630 Haemophilus influenzae PittGG intracellular septation protein A YP_001292766.1 1408115 D 374931 CDS YP_001292767.1 148828014 5227431 1409152..1409448 1 NC_009567.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; YciI-like protein 1409448 5227431 CGSHiGG_07645 Haemophilus influenzae PittGG YciI-like protein YP_001292767.1 1409152 D 374931 CDS YP_001292768.1 148828015 5227432 1409464..1411248 1 NC_009567.1 COG1196 Chromosome segregation ATPases; intracellular septation protein A 1411248 5227432 CGSHiGG_07650 Haemophilus influenzae PittGG intracellular septation protein A YP_001292768.1 1409464 D 374931 CDS YP_001292769.1 148828016 5227433 1411286..1411591 1 NC_009567.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 1411591 5227433 CGSHiGG_07655 Haemophilus influenzae PittGG Trp operon repressor YP_001292769.1 1411286 D 374931 CDS YP_001292770.1 148828017 5227434 1411631..1412317 1 NC_009567.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase 1412317 mtgA 5227434 mtgA Haemophilus influenzae PittGG monofunctional biosynthetic peptidoglycan transglycosylase YP_001292770.1 1411631 D 374931 CDS YP_001292771.1 148828018 5227435 complement(1412422..1412766) 1 NC_009567.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 1412766 5227435 CGSHiGG_07665 Haemophilus influenzae PittGG fumarate reductase subunit D YP_001292771.1 1412422 R 374931 CDS YP_001292772.1 148828019 5227436 complement(1412779..1413189) 1 NC_009567.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C 1413189 5227436 CGSHiGG_07670 Haemophilus influenzae PittGG fumarate reductase subunit C YP_001292772.1 1412779 R 374931 CDS YP_001292773.1 148828020 5227437 complement(1413214..1413969) 1 NC_009567.1 COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; fumarate reductase iron-sulfur subunit 1413969 5227437 CGSHiGG_07675 Haemophilus influenzae PittGG fumarate reductase iron-sulfur subunit YP_001292773.1 1413214 R 374931 CDS YP_001292774.1 148828021 5227438 1415971..1416942 1 NC_009567.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 1416942 5227438 CGSHiGG_07690 Haemophilus influenzae PittGG lysyl-tRNA synthetase YP_001292774.1 1415971 D 374931 CDS YP_001292775.1 148828022 5227439 complement(1417208..1417891) 1 NC_009567.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; response regulator 1417891 5227439 CGSHiGG_07695 Haemophilus influenzae PittGG response regulator YP_001292775.1 1417208 R 374931 CDS YP_001292776.1 148828023 5227440 complement(1417945..1418358) 1 NC_009567.1 COG2913 Small protein A (tmRNA-binding); small protein A 1418358 5227440 CGSHiGG_07700 Haemophilus influenzae PittGG small protein A YP_001292776.1 1417945 R 374931 CDS YP_001292777.1 148828024 5227441 complement(1418424..1419440) 1 NC_009567.1 COG3081 Nucleoid-associated protein; nucleoid-associated protein NdpA 1419440 5227441 CGSHiGG_07705 Haemophilus influenzae PittGG nucleoid-associated protein NdpA YP_001292777.1 1418424 R 374931 CDS YP_001292778.1 148828025 5227442 1419566..1419784 1 NC_009567.1 COG3082 Uncharacterized protein conserved in bacteria; hypothetical protein 1419784 5227442 CGSHiGG_07710 Haemophilus influenzae PittGG hypothetical protein YP_001292778.1 1419566 D 374931 CDS YP_001292779.1 148828026 5227443 1419786..1421549 1 NC_009567.1 COG3083 Predicted hydrolase of alkaline phosphatase superfamily; nucleoid-associated protein NdpA 1421549 5227443 CGSHiGG_07715 Haemophilus influenzae PittGG nucleoid-associated protein NdpA YP_001292779.1 1419786 D 374931 CDS YP_001292780.1 148828027 5227444 1421751..1422734 1 NC_009567.1 COG0402 Cytosine deaminase and related metal-dependent hydrolases; hypothetical protein 1422734 5227444 CGSHiGG_07720 Haemophilus influenzae PittGG hypothetical protein YP_001292780.1 1421751 D 374931 CDS YP_001292781.1 148828028 5227445 complement(1422873..1423397) 1 NC_009567.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA 1423397 mobA 5227445 mobA Haemophilus influenzae PittGG molybdopterin-guanine dinucleotide biosynthesis protein MobA YP_001292781.1 1422873 R 374931 CDS YP_001292782.1 148828029 5227446 1423513..1423779 1 NC_009567.1 COG3084 Uncharacterized protein conserved in bacteria; hypothetical protein 1423779 5227446 CGSHiGG_07730 Haemophilus influenzae PittGG hypothetical protein YP_001292782.1 1423513 D 374931 CDS YP_001292783.1 148828030 5227447 1423790..1424407 1 NC_009567.1 COG0526 Thiol-disulfide isomerase and thioredoxins; molybdopterin-guanine dinucleotide biosynthesis protein A 1424407 mobA 5227447 mobA Haemophilus influenzae PittGG molybdopterin-guanine dinucleotide biosynthesis protein A YP_001292783.1 1423790 D 374931 CDS YP_001292784.1 148828031 5227448 1424469..1424762 1 NC_009567.1 COG3085 Uncharacterized protein conserved in bacteria; hypothetical protein 1424762 5227448 CGSHiGG_07740 Haemophilus influenzae PittGG hypothetical protein YP_001292784.1 1424469 D 374931 CDS YP_001292785.1 148828032 5227449 1426021..1426794 1 NC_009567.1 COG0500 SAM-dependent methyltransferases; SAM-dependent methyltransferase 1426794 5227449 CGSHiGG_07755 Haemophilus influenzae PittGG SAM-dependent methyltransferase YP_001292785.1 1426021 D 374931 CDS YP_001292786.1 148828033 5227450 1426788..1427222 1 NC_009567.1 positive regulator of sigma E 1427222 5227450 CGSHiGG_07760 Haemophilus influenzae PittGG positive regulator of sigma E YP_001292786.1 1426788 D 374931 CDS YP_001292788.1 148828035 5227452 1427647..1428162 1 NC_009567.1 COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein; molybdopterin-guanine dinucleotide biosynthesis protein B 1428162 5227452 CGSHiGG_07770 Haemophilus influenzae PittGG molybdopterin-guanine dinucleotide biosynthesis protein B YP_001292788.1 1427647 D 374931 CDS YP_001292789.1 148828036 5227453 1428159..1429550 1 NC_009567.1 COG0477 Permeases of the major facilitator superfamily; hypothetical protein 1429550 5227453 CGSHiGG_07775 Haemophilus influenzae PittGG hypothetical protein YP_001292789.1 1428159 D 374931 CDS YP_001292790.1 148828037 5227454 1431516..1432277 1 NC_009567.1 COG0748 Putative heme iron utilization protein; putative heme iron utilization protein 1432277 5227454 CGSHiGG_07790 Haemophilus influenzae PittGG putative heme iron utilization protein YP_001292790.1 1431516 D 374931 CDS YP_001292791.1 148828038 5227455 complement(1432629..1432757) 1 NC_009567.1 COG3681 Uncharacterized conserved protein; hypothetical protein 1432757 5227455 CGSHiGG_07795 Haemophilus influenzae PittGG hypothetical protein YP_001292791.1 1432629 R 374931 CDS YP_001292792.1 148828039 5227456 complement(1432772..1435564) 1 NC_009567.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 1435564 5227456 CGSHiGG_07800 Haemophilus influenzae PittGG DNA polymerase I YP_001292792.1 1432772 R 374931 CDS YP_001292793.1 148828040 5227457 1435713..1436015 1 NC_009567.1 COG3027 Uncharacterized protein conserved in bacteria; hypothetical protein 1436015 5227457 CGSHiGG_07805 Haemophilus influenzae PittGG hypothetical protein YP_001292793.1 1435713 D 374931 CDS YP_001292794.1 148828041 5227458 1436333..1436896 1 NC_009567.1 COG0212 5-formyltetrahydrofolate cyclo-ligase; hypothetical protein 1436896 5227458 CGSHiGG_07810 Haemophilus influenzae PittGG hypothetical protein YP_001292794.1 1436333 D 374931 CDS YP_001292795.1 148828042 5227459 1437024..1439594 1 NC_009567.1 COG0542 ATPases with chaperone activity, ATP-binding subunit; DNA polymerase I 1439594 5227459 CGSHiGG_07815 Haemophilus influenzae PittGG DNA polymerase I YP_001292795.1 1437024 D 374931 CDS YP_001292796.1 148828043 5227460 complement(1439631..1440371) 1 NC_009567.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 1440371 5227460 CGSHiGG_07820 Haemophilus influenzae PittGG 23S rRNA (guanosine-2'-O-)-methyltransferase YP_001292796.1 1439631 R 374931 CDS YP_001292797.1 148828044 5227461 complement(1440427..1442775) 1 NC_009567.1 COG0557 Exoribonuclease R; 23S rRNA (guanosine-2'-O-)-methyltransferase 1442775 5227461 CGSHiGG_07825 Haemophilus influenzae PittGG 23S rRNA (guanosine-2'-O-)-methyltransferase YP_001292797.1 1440427 R 374931 CDS YP_001292798.1 148828045 5227462 complement(1442967..1443674) 1 NC_009567.1 COG1738 Uncharacterized conserved protein; hypothetical protein 1443674 5227462 CGSHiGG_07830 Haemophilus influenzae PittGG hypothetical protein YP_001292798.1 1442967 R 374931 CDS YP_001292799.1 148828046 5227463 1443867..1444499 1 NC_009567.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 1444499 5227463 CGSHiGG_07835 Haemophilus influenzae PittGG pyridoxamine 5'-phosphate oxidase YP_001292799.1 1443867 D 374931 CDS YP_001292800.1 148828047 5227464 complement(1444587..1446437) 1 NC_009567.1 GTP-binding protein TypA/ BipA 1446437 5227464 CGSHiGG_07840 Haemophilus influenzae PittGG GTP-binding protein TypA/ BipA YP_001292800.1 1444587 R 374931 CDS YP_001292801.1 148828048 5227465 complement(1446564..1447568) 1 NC_009567.1 COG1217 Predicted membrane GTPase involved in stress response; CMP-neu5Ac--lipooligosaccharide alpha 2-3 sialyltransferase 1447568 5227465 CGSHiGG_07845 Haemophilus influenzae PittGG CMP-neu5Ac--lipooligosaccharide alpha 2-3 sialyltransferase YP_001292801.1 1446564 R 374931 CDS YP_001292802.1 148828049 5227466 1447725..1449137 1 NC_009567.1 COG0174 Glutamine synthetase; glutamine synthetase 1449137 5227466 CGSHiGG_07850 Haemophilus influenzae PittGG glutamine synthetase YP_001292802.1 1447725 D 374931 CDS YP_001292803.1 148828050 5227467 1449614..1450117 1 NC_009567.1 COG3765 Chain length determinant protein; hypothetical protein 1450117 5227467 CGSHiGG_07855 Haemophilus influenzae PittGG hypothetical protein YP_001292803.1 1449614 D 374931 CDS YP_001292804.1 148828051 5227468 1451559..1452305 1 NC_009567.1 COG0463 Glycosyltransferases involved in cell wall biogenesis; hypothetical protein 1452305 5227468 CGSHiGG_07875 Haemophilus influenzae PittGG hypothetical protein YP_001292804.1 1451559 D 374931 CDS YP_001292805.1 148828052 5227469 1452310..1453194 1 NC_009567.1 COG1216 Predicted glycosyltransferases; hypothetical protein 1453194 5227469 CGSHiGG_07880 Haemophilus influenzae PittGG hypothetical protein YP_001292805.1 1452310 D 374931 CDS YP_001292806.1 148828053 5227470 1453673..1454239 1 NC_009567.1 putative polysaccharide polymerase 1454239 5227470 CGSHiGG_07885 Haemophilus influenzae PittGG putative polysaccharide polymerase YP_001292806.1 1453673 D 374931 CDS YP_001292807.1 148828054 5227471 1454381..1455259 1 NC_009567.1 COG3307 Lipid A core - O-antigen ligase and related enzymes; N-acetylneuraminic acid synthase-like protein 1455259 5227471 CGSHiGG_07890 Haemophilus influenzae PittGG N-acetylneuraminic acid synthase-like protein YP_001292807.1 1454381 D 374931 CDS YP_001292808.1 148828055 5227472 1455252..1456670 1 NC_009567.1 COG2148 Sugar transferases involved in lipopolysaccharide synthesis; undecaprenyl-phosphate galactosephosphotransferase 1456670 5227472 CGSHiGG_07895 Haemophilus influenzae PittGG undecaprenyl-phosphate galactosephosphotransferase YP_001292808.1 1455252 D 374931 CDS YP_001292809.1 148828056 5227473 1456742..1457746 1 NC_009567.1 COG1088 dTDP-D-glucose 4,6-dehydratase; dTDP-glucose 46-dehydratase 1457746 5227473 CGSHiGG_07900 Haemophilus influenzae PittGG dTDP-glucose 46-dehydratase YP_001292809.1 1456742 D 374931 CDS YP_001292810.1 148828057 5227474 1459156..1460460 1 NC_009567.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase B 1460460 5227474 CGSHiGG_07915 Haemophilus influenzae PittGG aminopeptidase B YP_001292810.1 1459156 D 374931 CDS YP_001292811.1 148828058 5227475 1460470..1460892 1 NC_009567.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1460892 ndk 5227475 ndk Haemophilus influenzae PittGG nucleoside diphosphate kinase YP_001292811.1 1460470 D 374931 CDS YP_001292812.1 148828059 5227476 complement(1460962..1462173) 1 NC_009567.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1462173 obgE 5227476 obgE Haemophilus influenzae PittGG GTPase ObgE YP_001292812.1 1460962 R 374931 CDS YP_001292813.1 148828060 5227477 complement(1463201..1463458) 1 NC_009567.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1463458 rpmA 5227477 rpmA Haemophilus influenzae PittGG 50S ribosomal protein L27 YP_001292813.1 1463201 R 374931 CDS YP_001292814.1 148828061 5227478 complement(1463479..1463790) 1 NC_009567.1 COG0261 Ribosomal protein L21; 50S ribosomal protein L21 1463790 rplU 5227478 rplU Haemophilus influenzae PittGG 50S ribosomal protein L21 YP_001292814.1 1463479 R 374931 CDS YP_001292815.1 148828062 5227479 1464021..1464992 1 NC_009567.1 COG0142 Geranylgeranyl pyrophosphate synthase; octaprenyl-diphosphate synthase 1464992 5227479 CGSHiGG_07950 Haemophilus influenzae PittGG octaprenyl-diphosphate synthase YP_001292815.1 1464021 D 374931 CDS YP_001292816.1 148828063 5227480 complement(1465838..1467208) 1 NC_009567.1 COG1115 Na+/alanine symporter; putative Na+/alanine symporter 1467208 5227480 CGSHiGG_07965 Haemophilus influenzae PittGG putative Na+/alanine symporter YP_001292816.1 1465838 R 374931 CDS YP_001292817.1 148828064 5227481 complement(1467607..1468317) 1 NC_009567.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; two-component response regulator 1468317 5227481 CGSHiGG_07970 Haemophilus influenzae PittGG two-component response regulator YP_001292817.1 1467607 R 374931 CDS YP_001292818.1 148828065 5227482 1468507..1470246 1 NC_009567.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein 1470246 dipZ 5227482 dipZ Haemophilus influenzae PittGG thiol:disulfide interchange protein YP_001292818.1 1468507 D 374931 CDS YP_001292819.1 148828066 5227483 1470358..1470762 1 NC_009567.1 COG2259 Predicted membrane protein; hypothetical protein 1470762 5227483 CGSHiGG_07980 Haemophilus influenzae PittGG hypothetical protein YP_001292819.1 1470358 D 374931 CDS YP_001292820.1 148828067 5227484 1470950..1472548 1 NC_009567.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1472548 purH 5227484 purH Haemophilus influenzae PittGG bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_001292820.1 1470950 D 374931 CDS YP_001292821.1 148828068 5227485 1472733..1474022 1 NC_009567.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 1474022 5227485 CGSHiGG_07990 Haemophilus influenzae PittGG phosphoribosylamine--glycine ligase YP_001292821.1 1472733 D 374931 CDS YP_001292822.1 148828069 5227486 1474146..1475411 1 NC_009567.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 1475411 glyA 5227486 glyA Haemophilus influenzae PittGG serine hydroxymethyltransferase YP_001292822.1 1474146 D 374931 CDS YP_001292823.1 148828070 5227487 1475482..1476102 1 NC_009567.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 1476102 coaE 5227487 coaE Haemophilus influenzae PittGG dephospho-CoA kinase YP_001292823.1 1475482 D 374931 CDS YP_001292824.1 148828071 5227488 1476095..1476301 1 NC_009567.1 COG3024 Uncharacterized protein conserved in bacteria; zinc-binding protein 1476301 5227488 CGSHiGG_08005 Haemophilus influenzae PittGG zinc-binding protein YP_001292824.1 1476095 D 374931 CDS YP_001292825.1 148828072 5227489 1476419..1477666 1 NC_009567.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB 1477666 5227489 CGSHiGG_08010 Haemophilus influenzae PittGG ATP-dependent RNA helicase RhlB YP_001292825.1 1476419 D 374931 CDS YP_001292827.1 148828074 5227491 1477908..1478471 1 NC_009567.1 COG1309 Transcriptional regulator; transcriptional repressor 1478471 5227491 CGSHiGG_08020 Haemophilus influenzae PittGG transcriptional repressor YP_001292827.1 1477908 D 374931 CDS YP_001292828.1 148828075 5227492 1478503..1479699 1 NC_009567.1 COG0845 Membrane-fusion protein; putative membrane-fusion protein 1479699 5227492 CGSHiGG_08025 Haemophilus influenzae PittGG putative membrane-fusion protein YP_001292828.1 1478503 D 374931 CDS YP_001292829.1 148828076 5227493 1479717..1482794 1 NC_009567.1 COG0841 Cation/multidrug efflux pump; acriflavine resistance protein 1482794 5227493 CGSHiGG_08030 Haemophilus influenzae PittGG acriflavine resistance protein YP_001292829.1 1479717 D 374931 CDS YP_001292830.1 148828077 5227494 1483029..1483799 1 NC_009567.1 COG3087 Cell division protein; cell division protein 1483799 5227494 CGSHiGG_08035 Haemophilus influenzae PittGG cell division protein YP_001292830.1 1483029 D 374931 CDS YP_001292831.1 148828078 5227495 complement(1485355..1486527) 1 NC_009567.1 COG1566 Multidrug resistance efflux pump; multidrug resistance protein A 1486527 5227495 CGSHiGG_08050 Haemophilus influenzae PittGG multidrug resistance protein A YP_001292831.1 1485355 R 374931 CDS YP_001292832.1 148828079 5227496 complement(1486709..1487191) 1 NC_009567.1 COG0262 Dihydrofolate reductase; dihydrofolate reductase 1487191 5227496 CGSHiGG_08055 Haemophilus influenzae PittGG dihydrofolate reductase YP_001292832.1 1486709 R 374931 CDS YP_001292833.1 148828080 5227497 1487292..1488398 1 NC_009567.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 1488398 5227497 CGSHiGG_08060 Haemophilus influenzae PittGG gamma-glutamyl kinase YP_001292833.1 1487292 D 374931 CDS YP_001292834.1 148828081 5227498 1488479..1489069 1 NC_009567.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 1489069 5227498 CGSHiGG_08065 Haemophilus influenzae PittGG dinucleoside polyphosphate hydrolase YP_001292834.1 1488479 D 374931 CDS YP_001292835.1 148828082 5227499 1489069..1489863 1 NC_009567.1 COG0730 Predicted permeases; hypothetical protein 1489863 5227499 CGSHiGG_08070 Haemophilus influenzae PittGG hypothetical protein YP_001292835.1 1489069 D 374931 CDS YP_001292836.1 148828083 5227500 1490687..1491538 1 NC_009567.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 1491538 thyA 5227500 thyA Haemophilus influenzae PittGG thymidylate synthase YP_001292836.1 1490687 D 374931 CDS YP_001292837.1 148828084 5227501 1491538..1491915 1 NC_009567.1 COG0590 Cytosine/adenosine deaminases; hypothetical protein 1491915 5227501 CGSHiGG_08090 Haemophilus influenzae PittGG hypothetical protein YP_001292837.1 1491538 D 374931 CDS YP_001292838.1 148828085 5227502 complement(1492087..1492401) 1 NC_009567.1 hypothetical protein 1492401 5227502 CGSHiGG_08095 Haemophilus influenzae PittGG hypothetical protein YP_001292838.1 1492087 R 374931 CDS YP_001292839.1 148828086 5227503 1492481..1492783 1 NC_009567.1 COG4701 Uncharacterized protein conserved in bacteria; hypothetical protein 1492783 5227503 CGSHiGG_08100 Haemophilus influenzae PittGG hypothetical protein YP_001292839.1 1492481 D 374931 CDS YP_001292840.1 148828087 5227504 1492908..1495613 1 NC_009567.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1495613 5227504 CGSHiGG_08105 Haemophilus influenzae PittGG preprotein translocase subunit SecA YP_001292840.1 1492908 D 374931 CDS YP_001292841.1 148828088 5227505 1495678..1496088 1 NC_009567.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; mutator protein MutT 1496088 5227505 CGSHiGG_08110 Haemophilus influenzae PittGG mutator protein MutT YP_001292841.1 1495678 D 374931 CDS YP_001292842.1 148828089 5227506 1496197..1498053 1 NC_009567.1 COG0475 Kef-type K+ transport systems, membrane components; glutathione-regulated potassium-efflux system protein 1498053 5227506 CGSHiGG_08115 Haemophilus influenzae PittGG glutathione-regulated potassium-efflux system protein YP_001292842.1 1496197 D 374931 CDS YP_001292843.1 148828090 5227507 1498173..1498937 1 NC_009567.1 COG0500 SAM-dependent methyltransferases; hypothetical protein 1498937 5227507 CGSHiGG_08120 Haemophilus influenzae PittGG hypothetical protein YP_001292843.1 1498173 D 374931 CDS YP_001292844.1 148828091 5227508 1499115..1499837 1 NC_009567.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 1499837 rpsB 5227508 rpsB Haemophilus influenzae PittGG 30S ribosomal protein S2 YP_001292844.1 1499115 D 374931 CDS YP_001292845.1 148828092 5227509 1499971..1500822 1 NC_009567.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 1500822 tsf 5227509 tsf Haemophilus influenzae PittGG elongation factor Ts YP_001292845.1 1499971 D 374931 CDS YP_001292846.1 148828093 5227510 complement(1500991..1502016) 1 NC_009567.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 1502016 lpxD 5227510 lpxD Haemophilus influenzae PittGG UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_001292846.1 1500991 R 374931 CDS YP_001292847.1 148828094 5227511 complement(1502029..1502622) 1 NC_009567.1 COG2825 Outer membrane protein; Outer membrane protein 26 1502622 5227511 CGSHiGG_08140 Haemophilus influenzae PittGG Outer membrane protein 26 YP_001292847.1 1502029 R 374931 CDS YP_001292848.1 148828095 5227512 complement(1502730..1505123) 1 NC_009567.1 COG4775 Outer membrane protein/protective antigen OMA87; protective surface antigen D15 1505123 5227512 CGSHiGG_08145 Haemophilus influenzae PittGG protective surface antigen D15 YP_001292848.1 1502730 R 374931 CDS YP_001292849.1 148828096 5227513 complement(1505143..1506474) 1 NC_009567.1 COG0750 Predicted membrane-associated Zn-dependent proteases 1; hypothetical protein 1506474 5227513 CGSHiGG_08150 Haemophilus influenzae PittGG hypothetical protein YP_001292849.1 1505143 R 374931 CDS YP_001292850.1 148828097 5227514 complement(1506484..1507350) 1 NC_009567.1 phosphatidate cytidylyltransferase 1507350 5227514 CGSHiGG_08155 Haemophilus influenzae PittGG phosphatidate cytidylyltransferase YP_001292850.1 1506484 R 374931 CDS YP_001292851.1 148828098 5227515 1508337..1510922 1 NC_009567.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 1510922 leuS 5227515 leuS Haemophilus influenzae PittGG leucyl-tRNA synthetase YP_001292851.1 1508337 D 374931 CDS YP_001292852.1 148828099 5227516 1511017..1511520 1 NC_009567.1 COG2980 Rare lipoprotein B; rare lipoprotein B 1511520 5227516 CGSHiGG_08175 Haemophilus influenzae PittGG rare lipoprotein B YP_001292852.1 1511017 D 374931 CDS YP_001292853.1 148828100 5227517 1511520..1512554 1 NC_009567.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 1512554 holA 5227517 holA Haemophilus influenzae PittGG DNA polymerase III subunit delta YP_001292853.1 1511520 D 374931 CDS YP_001292854.1 148828101 5227518 complement(1512788..1514854) 1 NC_009567.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 1514854 glyS 5227518 glyS Haemophilus influenzae PittGG glycyl-tRNA synthetase subunit beta YP_001292854.1 1512788 R 374931 CDS YP_001292855.1 148828102 5227519 complement(1515192..1515410) 1 NC_009567.1 COG2852 Uncharacterized protein conserved in bacteria; 50S ribosomal protein L27 1515410 rpmA 5227519 rpmA Haemophilus influenzae PittGG 50S ribosomal protein L27 YP_001292855.1 1515192 R 374931 CDS YP_001292856.1 148828103 5227520 complement(1515441..1515701) 1 NC_009567.1 hypothetical protein 1515701 5227520 CGSHiGG_08195 Haemophilus influenzae PittGG hypothetical protein YP_001292856.1 1515441 R 374931 CDS YP_001292857.1 148828104 5227521 complement(1515760..1516668) 1 NC_009567.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 1516668 glyQ 5227521 glyQ Haemophilus influenzae PittGG glycyl-tRNA synthetase subunit alpha YP_001292857.1 1515760 R 374931 CDS YP_001292858.1 148828105 5227522 1516932..1518458 1 NC_009567.1 hypothetical protein 1518458 5227522 CGSHiGG_08205 Haemophilus influenzae PittGG hypothetical protein YP_001292858.1 1516932 D 374931 CDS YP_001292859.1 148828106 5227523 complement(1518675..1519856) 1 NC_009567.1 hypothetical protein 1519856 5227523 CGSHiGG_08210 Haemophilus influenzae PittGG hypothetical protein YP_001292859.1 1518675 R 374931 CDS YP_001292860.1 148828107 5227524 complement(1519857..1520438) 1 NC_009567.1 hypothetical protein 1520438 5227524 CGSHiGG_08215 Haemophilus influenzae PittGG hypothetical protein YP_001292860.1 1519857 R 374931 CDS YP_001292861.1 148828108 5227525 complement(1520451..1520870) 1 NC_009567.1 hypothetical protein 1520870 5227525 CGSHiGG_08220 Haemophilus influenzae PittGG hypothetical protein YP_001292861.1 1520451 R 374931 CDS YP_001292862.1 148828109 5227526 complement(1520954..1522264) 1 NC_009567.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1522264 eno 5227526 eno Haemophilus influenzae PittGG phosphopyruvate hydratase YP_001292862.1 1520954 R 374931 CDS YP_001292863.1 148828110 5227527 complement(1522385..1523590) 1 NC_009567.1 hypothetical protein 1523590 5227527 CGSHiGG_08230 Haemophilus influenzae PittGG hypothetical protein YP_001292863.1 1522385 R 374931 CDS YP_001292864.1 148828111 5227528 complement(1523587..1524741) 1 NC_009567.1 hypothetical protein 1524741 5227528 CGSHiGG_08235 Haemophilus influenzae PittGG hypothetical protein YP_001292864.1 1523587 R 374931 CDS YP_001292865.1 148828112 5227529 complement(1524738..1525265) 1 NC_009567.1 hypothetical protein 1525265 5227529 CGSHiGG_08240 Haemophilus influenzae PittGG hypothetical protein YP_001292865.1 1524738 R 374931 CDS YP_001292866.1 148828113 5227530 complement(1525265..1527172) 1 NC_009567.1 hypothetical protein 1527172 5227530 CGSHiGG_08245 Haemophilus influenzae PittGG hypothetical protein YP_001292866.1 1525265 R 374931 CDS YP_001292867.1 148828114 5227531 complement(1527280..1528083) 1 NC_009567.1 hypothetical protein 1528083 5227531 CGSHiGG_08250 Haemophilus influenzae PittGG hypothetical protein YP_001292867.1 1527280 R 374931 CDS YP_001292868.1 148828115 5227532 1528283..1528795 1 NC_009567.1 hypothetical protein 1528795 5227532 CGSHiGG_08255 Haemophilus influenzae PittGG hypothetical protein YP_001292868.1 1528283 D 374931 CDS YP_001292869.1 148828116 5227533 1528795..1529511 1 NC_009567.1 hypothetical protein 1529511 5227533 CGSHiGG_08260 Haemophilus influenzae PittGG hypothetical protein YP_001292869.1 1528795 D 374931 CDS YP_001292870.1 148828117 5227534 1529526..1530209 1 NC_009567.1 hypothetical protein 1530209 5227534 CGSHiGG_08265 Haemophilus influenzae PittGG hypothetical protein YP_001292870.1 1529526 D 374931 CDS YP_001292871.1 148828118 5227535 1530202..1530489 1 NC_009567.1 hypothetical protein 1530489 5227535 CGSHiGG_08270 Haemophilus influenzae PittGG hypothetical protein YP_001292871.1 1530202 D 374931 CDS YP_001292872.1 148828119 5227536 1530535..1533915 1 NC_009567.1 exodeoxyribonuclease V subunit gamma 1533915 5227536 CGSHiGG_08275 Haemophilus influenzae PittGG exodeoxyribonuclease V subunit gamma YP_001292872.1 1530535 D 374931 CDS YP_001292873.1 148828120 5227537 1533970..1534332 1 NC_009567.1 hypothetical protein 1534332 5227537 CGSHiGG_08280 Haemophilus influenzae PittGG hypothetical protein YP_001292873.1 1533970 D 374931 CDS YP_001292874.1 148828121 5227538 1534423..1535541 1 NC_009567.1 hypothetical protein 1535541 5227538 CGSHiGG_08285 Haemophilus influenzae PittGG hypothetical protein YP_001292874.1 1534423 D 374931 CDS YP_001292875.1 148828122 5227539 1535542..1536564 1 NC_009567.1 hypothetical protein 1536564 5227539 CGSHiGG_08290 Haemophilus influenzae PittGG hypothetical protein YP_001292875.1 1535542 D 374931 CDS YP_001292876.1 148828123 5227540 complement(1536638..1537453) 1 NC_009567.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 1537453 5227540 CGSHiGG_08295 Haemophilus influenzae PittGG formamidopyrimidine-DNA glycosylase YP_001292876.1 1536638 R 374931 CDS YP_001292877.1 148828124 5227541 complement(1537685..1539220) 1 NC_009567.1 hypothetical protein 1539220 5227541 CGSHiGG_08300 Haemophilus influenzae PittGG hypothetical protein YP_001292877.1 1537685 R 374931 CDS YP_001292878.1 148828125 5227542 complement(1539240..1539638) 1 NC_009567.1 hypothetical protein 1539638 5227542 CGSHiGG_08305 Haemophilus influenzae PittGG hypothetical protein YP_001292878.1 1539240 R 374931 CDS YP_001292879.1 148828126 5227543 complement(1539638..1539871) 1 NC_009567.1 hypothetical protein 1539871 5227543 CGSHiGG_08310 Haemophilus influenzae PittGG hypothetical protein YP_001292879.1 1539638 R 374931 CDS YP_001292880.1 148828127 5227544 complement(1540018..1541382) 1 NC_009567.1 catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde; diaminobutyrate--2-oxoglutarate aminotransferase 1541382 5227544 CGSHiGG_08315 Haemophilus influenzae PittGG diaminobutyrate--2-oxoglutarate aminotransferase YP_001292880.1 1540018 R 374931 CDS YP_001292881.1 148828128 5227545 complement(1541729..1541899) 1 NC_009567.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 1541899 rpmG 5227545 rpmG Haemophilus influenzae PittGG 50S ribosomal protein L33 YP_001292881.1 1541729 R 374931 CDS YP_001292882.1 148828129 5227546 complement(1541911..1542147) 1 NC_009567.1 required for 70S ribosome assembly; 50S ribosomal protein L28 1542147 rpmB 5227546 rpmB Haemophilus influenzae PittGG 50S ribosomal protein L28 YP_001292882.1 1541911 R 374931 CDS YP_001292883.1 148828130 5227547 1543190..1544392 1 NC_009567.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 1544392 5227547 CGSHiGG_08340 Haemophilus influenzae PittGG bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_001292883.1 1543190 D 374931 CDS YP_001292884.1 148828131 5227548 1544440..1544895 1 NC_009567.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 1544895 dut 5227548 dut Haemophilus influenzae PittGG deoxyuridine 5'-triphosphate nucleotidohydrolase YP_001292884.1 1544440 D 374931 CDS YP_001292885.1 148828132 5227549 1544899..1545555 1 NC_009567.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 1545555 slmA 5227549 slmA Haemophilus influenzae PittGG nucleoid occlusion protein YP_001292885.1 1544899 D 374931 CDS YP_001292886.1 148828133 5227550 1545577..1545678 1 NC_009567.1 COG3089 Uncharacterized protein conserved in bacteria; nucleoid occlusion protein 1545678 slmA 5227550 slmA Haemophilus influenzae PittGG nucleoid occlusion protein YP_001292886.1 1545577 D 374931 CDS YP_001292887.1 148828134 5227551 1545813..1546487 1 NC_009567.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 1546487 5227551 CGSHiGG_08360 Haemophilus influenzae PittGG cAMP-regulatory protein YP_001292887.1 1545813 D 374931 CDS YP_001292888.1 148828135 5227552 complement(1546852..1548030) 1 NC_009567.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 1548030 rumB 5227552 rumB Haemophilus influenzae PittGG 23S rRNA methyluridine methyltransferase YP_001292888.1 1546852 R 374931 CDS YP_001292889.1 148828136 5227553 complement(1548027..1549070) 1 NC_009567.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1549070 5227553 CGSHiGG_08370 Haemophilus influenzae PittGG beta-hexosaminidase YP_001292889.1 1548027 R 374931 CDS YP_001292890.1 148828137 5227554 complement(1549083..1549433) 1 NC_009567.1 COG5633 Predicted periplasmic lipoprotein; hypothetical protein 1549433 5227554 CGSHiGG_08375 Haemophilus influenzae PittGG hypothetical protein YP_001292890.1 1549083 R 374931 CDS YP_001292891.1 148828138 5227555 complement(1549433..1549783) 1 NC_009567.1 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases; beta-hexosaminidase 1549783 5227555 CGSHiGG_08380 Haemophilus influenzae PittGG beta-hexosaminidase YP_001292891.1 1549433 R 374931 CDS YP_001292892.1 148828139 5227556 complement(1549901..1552726) 1 NC_009567.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 1552726 ileS 5227556 ileS Haemophilus influenzae PittGG isoleucyl-tRNA synthetase YP_001292892.1 1549901 R 374931 CDS YP_001292893.1 148828140 5227557 complement(1552754..1553680) 1 NC_009567.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1553680 5227557 CGSHiGG_08390 Haemophilus influenzae PittGG bifunctional riboflavin kinase/FMN adenylyltransferase YP_001292893.1 1552754 R 374931 CDS YP_001292894.1 148828141 5227558 complement(1553727..1555301) 1 NC_009567.1 bifunctional riboflavin kinase/FMN adenylyltransferase 1555301 5227558 CGSHiGG_08395 Haemophilus influenzae PittGG bifunctional riboflavin kinase/FMN adenylyltransferase YP_001292894.1 1553727 R 374931 CDS YP_001292895.1 148828142 5227559 complement(1555354..1555635) 1 NC_009567.1 COG0728 Uncharacterized membrane protein, putative virulence factor; hypothetical protein 1555635 5227559 CGSHiGG_08400 Haemophilus influenzae PittGG hypothetical protein YP_001292895.1 1555354 R 374931 CDS YP_001292896.1 148828143 5227560 1555647..1555832 1 NC_009567.1 30S ribosomal protein S20 1555832 5227560 CGSHiGG_08405 Haemophilus influenzae PittGG 30S ribosomal protein S20 YP_001292896.1 1555647 D 374931 CDS YP_001292897.1 148828144 5227561 complement(1555905..1556471) 1 NC_009567.1 hypothetical protein 1556471 5227561 CGSHiGG_08410 Haemophilus influenzae PittGG hypothetical protein YP_001292897.1 1555905 R 374931 CDS YP_001292898.1 148828145 5227562 1556497..1556601 1 NC_009567.1 COG0268 Ribosomal protein S20; 30S ribosomal protein S20 1556601 rpsT 5227562 rpsT Haemophilus influenzae PittGG 30S ribosomal protein S20 YP_001292898.1 1556497 D 374931 CDS YP_001292899.1 148828146 5227563 1556617..1557474 1 NC_009567.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 1557474 5227563 CGSHiGG_08420 Haemophilus influenzae PittGG naphthoate synthase YP_001292899.1 1556617 D 374931 CDS YP_001292900.1 148828147 5227564 1557543..1558532 1 NC_009567.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 1558532 5227564 CGSHiGG_08425 Haemophilus influenzae PittGG O-succinylbenzoate synthase YP_001292900.1 1557543 D 374931 CDS YP_001292901.1 148828148 5227565 1558589..1559038 1 NC_009567.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 1559038 5227565 CGSHiGG_08430 Haemophilus influenzae PittGG 3-dehydroquinate dehydratase YP_001292901.1 1558589 D 374931 CDS YP_001292902.1 148828149 5227566 1559191..1559658 1 NC_009567.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 1559658 5227566 CGSHiGG_08435 Haemophilus influenzae PittGG acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_001292902.1 1559191 D 374931 CDS YP_001292903.1 148828150 5227567 1559835..1561181 1 NC_009567.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 1561181 5227567 CGSHiGG_08440 Haemophilus influenzae PittGG acetyl-CoA carboxylase biotin carboxylase subunit YP_001292903.1 1559835 D 374931 CDS YP_001292904.1 148828151 5227568 1561384..1561641 1 NC_009567.1 COG3924 Predicted membrane protein; acetyl-CoA carboxylase biotin carboxylase subunit 1561641 5227568 CGSHiGG_08445 Haemophilus influenzae PittGG acetyl-CoA carboxylase biotin carboxylase subunit YP_001292904.1 1561384 D 374931 CDS YP_001292905.1 148828152 5227569 1561638..1563092 1 NC_009567.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 1563092 panF 5227569 panF Haemophilus influenzae PittGG sodium/panthothenate symporter YP_001292905.1 1561638 D 374931 CDS YP_001292906.1 148828153 5227570 1564120..1565007 1 NC_009567.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 1565007 prmA 5227570 prmA Haemophilus influenzae PittGG ribosomal protein L11 methyltransferase YP_001292906.1 1564120 D 374931 CDS YP_001292907.1 148828154 5227571 1565154..1566134 1 NC_009567.1 COG0042 tRNA-dihydrouridine synthase; ribosomal protein L11 methyltransferase 1566134 prmA 5227571 prmA Haemophilus influenzae PittGG ribosomal protein L11 methyltransferase YP_001292907.1 1565154 D 374931 CDS YP_001292908.1 148828155 5227572 1566128..1566427 1 NC_009567.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 1566427 fis 5227572 fis Haemophilus influenzae PittGG DNA-binding protein Fis YP_001292908.1 1566128 D 374931 CDS YP_001292909.1 148828156 5227573 complement(1566522..1567007) 1 NC_009567.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 1567007 smpB 5227573 smpB Haemophilus influenzae PittGG SsrA-binding protein YP_001292909.1 1566522 R 374931 CDS YP_001292910.1 148828157 5227574 complement(1567246..1568163) 1 NC_009567.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 1568163 5227574 CGSHiGG_08485 Haemophilus influenzae PittGG 6-phosphofructokinase YP_001292910.1 1567246 R 374931 CDS YP_001292911.1 148828158 5227575 complement(1568308..1568889) 1 NC_009567.1 COG0205 6-phosphofructokinase; hypothetical protein 1568889 5227575 CGSHiGG_08490 Haemophilus influenzae PittGG hypothetical protein YP_001292911.1 1568308 R 374931 CDS YP_001292912.1 148828159 5227576 complement(1568882..1569658) 1 NC_009567.1 COG3022 Uncharacterized protein conserved in bacteria; hypothetical protein 1569658 5227576 CGSHiGG_08495 Haemophilus influenzae PittGG hypothetical protein YP_001292912.1 1568882 R 374931 CDS YP_001292913.1 148828160 5227577 complement(1569711..1570832) 1 NC_009567.1 COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake; hypothetical protein 1570832 5227577 CGSHiGG_08500 Haemophilus influenzae PittGG hypothetical protein YP_001292913.1 1569711 R 374931 CDS YP_001292914.1 148828161 5227578 1574323..1575690 1 NC_009567.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 1575690 5227578 CGSHiGG_08525 Haemophilus influenzae PittGG isopropylmalate isomerase large subunit YP_001292914.1 1574323 D 374931 CDS YP_001292915.1 148828162 5227579 1575701..1576303 1 NC_009567.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 1576303 leuD 5227579 leuD Haemophilus influenzae PittGG isopropylmalate isomerase small subunit YP_001292915.1 1575701 D 374931 CDS YP_001292916.1 148828163 5227580 complement(1583192..1584292) 1 NC_009567.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 1584292 5227580 CGSHiGG_08555 Haemophilus influenzae PittGG DNA polymerase III subunit beta YP_001292916.1 1583192 R 374931 CDS YP_001292917.1 148828164 5227581 complement(1584551..1585915) 1 NC_009567.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1585915 dnaA 5227581 dnaA Haemophilus influenzae PittGG chromosomal replication initiation protein YP_001292917.1 1584551 R 374931 CDS YP_001292918.1 148828165 5227582 1588871..1588996 1 NC_009567.1 hypothetical protein 1588996 5227582 CGSHiGG_08575 Haemophilus influenzae PittGG hypothetical protein YP_001292918.1 1588871 D 374931 CDS YP_001292919.1 148828166 5227583 complement(1589382..1590818) 1 NC_009567.1 transferrin-binding protein 2 1590818 5227583 CGSHiGG_08580 Haemophilus influenzae PittGG transferrin-binding protein 2 YP_001292919.1 1589382 R 374931 CDS YP_001292920.1 148828167 5227584 1590914..1592359 1 NC_009567.1 COG1629 Outer membrane receptor proteins, mostly Fe transport; chromosomal replication initiation protein 1592359 dnaA 5227584 dnaA Haemophilus influenzae PittGG chromosomal replication initiation protein YP_001292920.1 1590914 D 374931 CDS YP_001292921.1 148828168 5227585 1592535..1592669 1 NC_009567.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 1592669 rpmH 5227585 rpmH Haemophilus influenzae PittGG 50S ribosomal protein L34 YP_001292921.1 1592535 D 374931 CDS YP_001292922.1 148828169 5227586 1592682..1593041 1 NC_009567.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 1593041 rnpA 5227586 rnpA Haemophilus influenzae PittGG ribonuclease P YP_001292922.1 1592682 D 374931 CDS YP_001292923.1 148828170 5227587 1593005..1593265 1 NC_009567.1 COG0759 Uncharacterized conserved protein; hypothetical protein 1593265 5227587 CGSHiGG_08600 Haemophilus influenzae PittGG hypothetical protein YP_001292923.1 1593005 D 374931 CDS YP_001292924.1 148828171 5227588 1595136..1596494 1 NC_009567.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 1596494 trmE 5227588 trmE Haemophilus influenzae PittGG tRNA modification GTPase TrmE YP_001292924.1 1595136 D 374931 CDS YP_001292925.1 148828172 5227589 1596682..1598550 1 NC_009567.1 COG0760 Parvulin-like peptidyl-prolyl isomerase; peptidyl-prolyl cis-trans isomerase D 1598550 5227589 CGSHiGG_08620 Haemophilus influenzae PittGG peptidyl-prolyl cis-trans isomerase D YP_001292925.1 1596682 D 374931 CDS YP_001292926.1 148828173 5227590 1598641..1600197 1 NC_009567.1 COG2194 Predicted membrane-associated, metal-dependent hydrolase; tRNA modification GTPase TrmE 1600197 trmE 5227590 trmE Haemophilus influenzae PittGG tRNA modification GTPase TrmE YP_001292926.1 1598641 D 374931 CDS YP_001292927.1 148828174 5227591 1600267..1600782 1 NC_009567.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 1600782 lspA 5227591 lspA Haemophilus influenzae PittGG lipoprotein signal peptidase YP_001292927.1 1600267 D 374931 CDS YP_001292928.1 148828175 5227592 1600779..1601723 1 NC_009567.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1601723 ispH 5227592 ispH Haemophilus influenzae PittGG 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_001292928.1 1600779 D 374931 CDS YP_001292929.1 148828176 5227593 1601892..1602239 1 NC_009567.1 COG1555 DNA uptake protein and related DNA-binding proteins; hypothetical protein 1602239 5227593 CGSHiGG_08640 Haemophilus influenzae PittGG hypothetical protein YP_001292929.1 1601892 D 374931 CDS YP_001292930.1 148828177 5227594 1603214..1604119 1 NC_009567.1 3-hydroxyisobutyrate dehydrogenase 1604119 5227594 CGSHiGG_08655 Haemophilus influenzae PittGG 3-hydroxyisobutyrate dehydrogenase YP_001292930.1 1603214 D 374931 CDS YP_001292931.1 148828178 5227595 1604122..1604193 1 NC_009567.1 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases; hypothetical protein 1604193 5227595 CGSHiGG_08660 Haemophilus influenzae PittGG hypothetical protein YP_001292931.1 1604122 D 374931 CDS YP_001292932.1 148828179 5227596 1604205..1605362 1 NC_009567.1 COG3395 Uncharacterized protein conserved in bacteria; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1605362 ispH 5227596 ispH Haemophilus influenzae PittGG 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_001292932.1 1604205 D 374931 CDS YP_001292933.1 148828180 5227597 1605359..1605991 1 NC_009567.1 COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; putative aldolase 1605991 5227597 CGSHiGG_08670 Haemophilus influenzae PittGG putative aldolase YP_001292933.1 1605359 D 374931 CDS YP_001292934.1 148828181 5227598 1605994..1606770 1 NC_009567.1 COG3622 Hydroxypyruvate isomerase; hypothetical protein 1606770 5227598 CGSHiGG_08675 Haemophilus influenzae PittGG hypothetical protein YP_001292934.1 1605994 D 374931 CDS YP_001292935.1 148828182 5227599 1606865..1608217 1 NC_009567.1 COG2610 H+/gluconate symporter and related permeases; gluconate transport protein GntT 1608217 5227599 CGSHiGG_08680 Haemophilus influenzae PittGG gluconate transport protein GntT YP_001292935.1 1606865 D 374931 CDS YP_001292936.1 148828183 5227600 1608275..1609609 1 NC_009567.1 COG4099 Predicted peptidase; hypothetical protein 1609609 5227600 CGSHiGG_08685 Haemophilus influenzae PittGG hypothetical protein YP_001292936.1 1608275 D 374931 CDS YP_001292937.1 148828184 5227601 1609621..1610307 1 NC_009567.1 COG1878 Predicted metal-dependent hydrolase; hypothetical protein 1610307 5227601 CGSHiGG_08690 Haemophilus influenzae PittGG hypothetical protein YP_001292937.1 1609621 D 374931 CDS YP_001292938.1 148828185 5227602 1610373..1611086 1 NC_009567.1 COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family); glycerol uptake facilitator protein 1611086 5227602 CGSHiGG_08695 Haemophilus influenzae PittGG glycerol uptake facilitator protein YP_001292938.1 1610373 D 374931 CDS YP_001292939.1 148828186 5227603 complement(1611154..1611288) 1 NC_009567.1 COG3676 Transposase and inactivated derivatives; transposase 1611288 5227603 CGSHiGG_08700 Haemophilus influenzae PittGG transposase YP_001292939.1 1611154 R 374931 CDS YP_001292940.1 148828187 5227604 1611859..1612857 1 NC_009567.1 COG4143 ABC-type thiamine transport system, periplasmic component; putative aldolase 1612857 5227604 CGSHiGG_08705 Haemophilus influenzae PittGG putative aldolase YP_001292940.1 1611859 D 374931 CDS YP_001292941.1 148828188 5227605 1614463..1615110 1 NC_009567.1 COG3840 ABC-type thiamine transport system, ATPase component; thiamin ABC transporter ATP-binding protein 1615110 5227605 CGSHiGG_08720 Haemophilus influenzae PittGG thiamin ABC transporter ATP-binding protein YP_001292941.1 1614463 D 374931 CDS YP_001292942.1 148828189 5227606 1615223..1616221 1 NC_009567.1 COG0502 Biotin synthase and related enzymes; thiamin transporter membrane protein 1616221 thiP 5227606 thiP Haemophilus influenzae PittGG thiamin transporter membrane protein YP_001292942.1 1615223 D 374931 CDS YP_001292943.1 148828190 5227607 complement(1616348..1618345) 1 NC_009567.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1618345 5227607 CGSHiGG_08730 Haemophilus influenzae PittGG transketolase YP_001292943.1 1616348 R 374931 CDS YP_001292944.1 148828191 5227608 complement(1618474..1619151) 1 NC_009567.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 1619151 ulaD 5227608 ulaD Haemophilus influenzae PittGG 3-keto-L-gulonate-6-phosphate decarboxylase YP_001292944.1 1618474 R 374931 CDS YP_001292945.1 148828192 5227609 complement(1619891..1620751) 1 NC_009567.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; putative L-xylulose 5-phosphate 3-epimerase 1620751 5227609 CGSHiGG_08750 Haemophilus influenzae PittGG putative L-xylulose 5-phosphate 3-epimerase YP_001292945.1 1619891 R 374931 CDS YP_001292946.1 148828193 5227610 complement(1620765..1622222) 1 NC_009567.1 COG1070 Sugar (pentulose and hexulose) kinases; L-xylulose kinase 1622222 5227610 CGSHiGG_08755 Haemophilus influenzae PittGG L-xylulose kinase YP_001292946.1 1620765 R 374931 CDS YP_001292947.1 148828194 5227611 complement(1622281..1623267) 1 NC_009567.1 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component; hypothetical protein 1623267 5227611 CGSHiGG_08760 Haemophilus influenzae PittGG hypothetical protein YP_001292947.1 1622281 R 374931 CDS YP_001292948.1 148828195 5227612 complement(1623298..1624575) 1 NC_009567.1 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component; hypothetical protein 1624575 5227612 CGSHiGG_08765 Haemophilus influenzae PittGG hypothetical protein YP_001292948.1 1623298 R 374931 CDS YP_001292949.1 148828196 5227613 complement(1624572..1625054) 1 NC_009567.1 COG3090 TRAP-type C4-dicarboxylate transport system, small permease component; hypothetical protein 1625054 5227613 CGSHiGG_08770 Haemophilus influenzae PittGG hypothetical protein YP_001292949.1 1624572 R 374931 CDS YP_001292950.1 148828197 5227614 complement(1625129..1626127) 1 NC_009567.1 NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; 2,3-diketo-L-gulonate reductase 1626127 5227614 CGSHiGG_08775 Haemophilus influenzae PittGG 2,3-diketo-L-gulonate reductase YP_001292950.1 1625129 R 374931 CDS YP_001292951.1 148828198 5227615 1626321..1627109 1 NC_009567.1 COG1414 Transcriptional regulator; L-ribulose-5-phosphate 4-epimerase 1627109 araD 5227615 araD Haemophilus influenzae PittGG L-ribulose-5-phosphate 4-epimerase YP_001292951.1 1626321 D 374931 CDS YP_001292952.1 148828199 5227616 1627259..1628203 1 NC_009567.1 catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 1628203 serB 5227616 serB Haemophilus influenzae PittGG phosphoserine phosphatase YP_001292952.1 1627259 D 374931 CDS YP_001292953.1 148828200 5227617 1628221..1628712 1 NC_009567.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; putative nucleotide-binding protein 1628712 5227617 CGSHiGG_08790 Haemophilus influenzae PittGG putative nucleotide-binding protein YP_001292953.1 1628221 D 374931 CDS YP_001292954.1 148828201 5227618 1629008..1629955 1 NC_009567.1 responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 1629955 5227618 CGSHiGG_08795 Haemophilus influenzae PittGG magnesium/nickel/cobalt transporter CorA YP_001292954.1 1629008 D 374931 CDS YP_001292955.1 148828202 5227619 1629955..1630500 1 NC_009567.1 COG0762 Predicted integral membrane protein; integral membrane protein 1630500 5227619 CGSHiGG_08800 Haemophilus influenzae PittGG integral membrane protein YP_001292955.1 1629955 D 374931 CDS YP_001292956.1 148828203 5227620 complement(1630681..1631517) 1 NC_009567.1 COG0121 Predicted glutamine amidotransferase; hypothetical protein 1631517 5227620 CGSHiGG_08805 Haemophilus influenzae PittGG hypothetical protein YP_001292956.1 1630681 R 374931 CDS YP_001292957.1 148828204 5227621 1631957..1633147 1 NC_009567.1 hypothetical protein 1633147 5227621 CGSHiGG_08810 Haemophilus influenzae PittGG hypothetical protein YP_001292957.1 1631957 D 374931 CDS YP_001292958.1 148828205 5227622 1633398..1633538 1 NC_009567.1 hypothetical protein 1633538 5227622 CGSHiGG_08815 Haemophilus influenzae PittGG hypothetical protein YP_001292958.1 1633398 D 374931 CDS YP_001292959.1 148828206 5227623 complement(1633686..1633790) 1 NC_009567.1 COG1373 Predicted ATPase (AAA+ superfamily); hypothetical protein 1633790 5227623 CGSHiGG_08820 Haemophilus influenzae PittGG hypothetical protein YP_001292959.1 1633686 R 374931 CDS YP_001292960.1 148828207 5227624 complement(1637590..1637691) 1 NC_009567.1 COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain; hypothetical protein 1637691 5227624 CGSHiGG_08845 Haemophilus influenzae PittGG hypothetical protein YP_001292960.1 1637590 R 374931 CDS YP_001292961.1 148828208 5227625 complement(1637798..1638298) 1 NC_009567.1 COG1145 Ferredoxin; B12-dependent methionine synthase 1638298 metH 5227625 metH Haemophilus influenzae PittGG B12-dependent methionine synthase YP_001292961.1 1637798 R 374931 CDS YP_001292962.1 148828209 5227626 complement(1638298..1638909) 1 NC_009567.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1638909 5227626 CGSHiGG_08855 Haemophilus influenzae PittGG twin-argninine leader-binding protein DmsD YP_001292962.1 1638298 R 374931 CDS YP_001292963.1 148828210 5227627 complement(1639021..1639860) 1 NC_009567.1 COG3302 DMSO reductase anchor subunit; anaerobic dimethyl sulfoxide reductase chain C 1639860 5227627 CGSHiGG_08860 Haemophilus influenzae PittGG anaerobic dimethyl sulfoxide reductase chain C YP_001292963.1 1639021 R 374931 CDS YP_001292964.1 148828211 5227628 complement(1639862..1640479) 1 NC_009567.1 COG0437 Fe-S-cluster-containing hydrogenase components 1; anaerobic dimethyl sulfoxide reductase chain B 1640479 5227628 CGSHiGG_08865 Haemophilus influenzae PittGG anaerobic dimethyl sulfoxide reductase chain B YP_001292964.1 1639862 R 374931 CDS YP_001292965.1 148828212 5227629 complement(1640490..1640639) 1 NC_009567.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; anaerobic dimethyl sulfoxide reductase chain A 1640639 5227629 CGSHiGG_08870 Haemophilus influenzae PittGG anaerobic dimethyl sulfoxide reductase chain A YP_001292965.1 1640490 R 374931 CDS YP_001292966.1 148828213 5227630 complement(1640630..1642909) 1 NC_009567.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; anaerobic dimethyl sulfoxide reductase chain A 1642909 5227630 CGSHiGG_08875 Haemophilus influenzae PittGG anaerobic dimethyl sulfoxide reductase chain A YP_001292966.1 1640630 R 374931 CDS YP_001292967.1 148828214 5227631 1643162..1644271 1 NC_009567.1 hypothetical protein 1644271 5227631 CGSHiGG_08880 Haemophilus influenzae PittGG hypothetical protein YP_001292967.1 1643162 D 374931 CDS YP_001292968.1 148828215 5227632 1644246..1644608 1 NC_009567.1 COG1305 Transglutaminase-like enzymes, putative cysteine proteases; hypothetical protein 1644608 5227632 CGSHiGG_08885 Haemophilus influenzae PittGG hypothetical protein YP_001292968.1 1644246 D 374931 CDS YP_001292969.1 148828216 5227633 1644617..1644895 1 NC_009567.1 COG2608 Copper chaperone; hypothetical protein 1644895 5227633 CGSHiGG_08890 Haemophilus influenzae PittGG hypothetical protein YP_001292969.1 1644617 D 374931 CDS YP_001292970.1 148828217 5227634 complement(1645019..1646863) 1 NC_009567.1 COG1132 ABC-type multidrug transport system, ATPase and permease components; ABC transporter ATP-binding protein 1646863 5227634 CGSHiGG_08895 Haemophilus influenzae PittGG ABC transporter ATP-binding protein YP_001292970.1 1645019 R 374931 CDS YP_001292971.1 148828218 5227635 complement(1646942..1647838) 1 NC_009567.1 COG2207 AraC-type DNA-binding domain-containing proteins; transcriptional regulator AraC family protein 1647838 5227635 CGSHiGG_08900 Haemophilus influenzae PittGG transcriptional regulator AraC family protein YP_001292971.1 1646942 R 374931 CDS YP_001292972.1 148828219 5227636 1647950..1648291 1 NC_009567.1 COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit; hypothetical protein 1648291 5227636 CGSHiGG_08905 Haemophilus influenzae PittGG hypothetical protein YP_001292972.1 1647950 D 374931 CDS YP_001292973.1 148828220 5227637 complement(1648391..1648990) 1 NC_009567.1 COG3421 Uncharacterized protein conserved in bacteria; hypothetical protein 1648990 5227637 CGSHiGG_08910 Haemophilus influenzae PittGG hypothetical protein YP_001292973.1 1648391 R 374931 CDS YP_001292974.1 148828221 5227638 complement(1649002..1651158) 1 NC_009567.1 COG3421 Uncharacterized protein conserved in bacteria; putative type III restriction-modification system HindVIP enzyme res 1651158 5227638 CGSHiGG_08915 Haemophilus influenzae PittGG putative type III restriction-modification system HindVIP enzyme res YP_001292974.1 1649002 R 374931 CDS YP_001292975.1 148828222 5227639 complement(1651148..1653322) 1 NC_009567.1 COG2189 Adenine specific DNA methylase Mod; twin-argninine leader-binding protein DmsD 1653322 5227639 CGSHiGG_08920 Haemophilus influenzae PittGG twin-argninine leader-binding protein DmsD YP_001292975.1 1651148 R 374931 CDS YP_001292976.1 148828223 5227640 complement(1653536..1654129) 1 NC_009567.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1654129 rnhB 5227640 rnhB Haemophilus influenzae PittGG ribonuclease HII YP_001292976.1 1653536 R 374931 CDS YP_001292977.1 148828224 5227641 complement(1654122..1655294) 1 NC_009567.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 1655294 lpxB 5227641 lpxB Haemophilus influenzae PittGG lipid-A-disaccharide synthase YP_001292977.1 1654122 R 374931 CDS YP_001292978.1 148828225 5227642 complement(1656165..1656611) 1 NC_009567.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 1656611 fabZ 5227642 fabZ Haemophilus influenzae PittGG (3R)-hydroxymyristoyl-ACP dehydratase YP_001292978.1 1656165 R 374931 CDS YP_001292979.1 148828226 5227643 complement(1656697..1658256) 1 NC_009567.1 COG2194 Predicted membrane-associated, metal-dependent hydrolase; UDP-N-acetylglucosamine acyltransferase 1658256 5227643 CGSHiGG_08950 Haemophilus influenzae PittGG UDP-N-acetylglucosamine acyltransferase YP_001292979.1 1656697 R 374931 CDS YP_001292980.1 148828227 5227644 1658387..1659100 1 NC_009567.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 1659100 pyrH 5227644 pyrH Haemophilus influenzae PittGG uridylate kinase YP_001292980.1 1658387 D 374931 CDS YP_001292981.1 148828228 5227645 complement(1660300..1660977) 1 NC_009567.1 uridylate kinase 1660977 pyrH 5227645 pyrH Haemophilus influenzae PittGG uridylate kinase YP_001292981.1 1660300 R 374931 CDS YP_001292982.1 148828229 5227646 complement(1660974..1661624) 1 NC_009567.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 1661624 5227646 CGSHiGG_08975 Haemophilus influenzae PittGG cytochrome c nitrite reductase pentaheme subunit YP_001292982.1 1660974 R 374931 CDS YP_001292983.1 148828230 5227647 complement(1661701..1663227) 1 NC_009567.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 1663227 nrfA 5227647 nrfA Haemophilus influenzae PittGG cytochrome c552 YP_001292983.1 1661701 R 374931 CDS YP_001292984.1 148828231 5227648 complement(1663479..1667390) 1 NC_009567.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1667390 5227648 CGSHiGG_08985 Haemophilus influenzae PittGG ATP-dependent RNA helicase HrpA YP_001292984.1 1663479 R 374931 CDS YP_001292985.1 148828232 5227649 complement(1667387..1667761) 1 NC_009567.1 COG2363 Uncharacterized small membrane protein; hypothetical protein 1667761 5227649 CGSHiGG_08990 Haemophilus influenzae PittGG hypothetical protein YP_001292985.1 1667387 R 374931 CDS YP_001292986.1 148828233 5227650 complement(1667762..1668214) 1 NC_009567.1 hypothetical protein 1668214 5227650 CGSHiGG_08995 Haemophilus influenzae PittGG hypothetical protein YP_001292986.1 1667762 R 374931 CDS YP_001292987.1 148828234 5227651 complement(1668370..1668468) 1 NC_009567.1 COG2707 Predicted membrane protein; hypothetical protein 1668468 5227651 CGSHiGG_09000 Haemophilus influenzae PittGG hypothetical protein YP_001292987.1 1668370 R 374931 CDS YP_001292988.1 148828235 5227652 complement(1668480..1669616) 1 NC_009567.1 COG1294 Cytochrome bd-type quinol oxidase, subunit 2; putative cytochrome oxidase subunit II 1669616 5227652 CGSHiGG_09005 Haemophilus influenzae PittGG putative cytochrome oxidase subunit II YP_001292988.1 1668480 R 374931 CDS YP_001292989.1 148828236 5227653 complement(1669631..1671196) 1 NC_009567.1 ATP-dependent RNA helicase HrpA 1671196 5227653 CGSHiGG_09010 Haemophilus influenzae PittGG ATP-dependent RNA helicase HrpA YP_001292989.1 1669631 R 374931 CDS YP_001292990.1 148828237 5227654 complement(1671641..1671820) 1 NC_009567.1 COG1271 Cytochrome bd-type quinol oxidase, subunit 1; hypothetical protein 1671820 5227654 CGSHiGG_09015 Haemophilus influenzae PittGG hypothetical protein YP_001292990.1 1671641 R 374931 CDS YP_001292991.1 148828238 5227655 1671849..1673486 1 NC_009567.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 1673486 pyrG 5227655 pyrG Haemophilus influenzae PittGG CTP synthetase YP_001292991.1 1671849 D 374931 CDS YP_001292992.1 148828239 5227656 complement(1673854..1674312) 1 NC_009567.1 COG3201 Nicotinamide mononucleotide transporter; nicotinamide riboside transporter 1674312 5227656 CGSHiGG_09025 Haemophilus influenzae PittGG nicotinamide riboside transporter YP_001292992.1 1673854 R 374931 CDS YP_001292993.1 148828240 5227657 complement(1674494..1675261) 1 NC_009567.1 COG1126 ABC-type polar amino acid transport system, ATPase component; putative amino-acid ABC transporter ATP-binding protein 1675261 5227657 CGSHiGG_09030 Haemophilus influenzae PittGG putative amino-acid ABC transporter ATP-binding protein YP_001292993.1 1674494 R 374931 CDS YP_001292994.1 148828241 5227658 complement(1675271..1675987) 1 NC_009567.1 COG0765 ABC-type amino acid transport system, permease component; ABC-type amino acid transport system permease 1675987 5227658 CGSHiGG_09035 Haemophilus influenzae PittGG ABC-type amino acid transport system permease YP_001292994.1 1675271 R 374931 CDS YP_001292995.1 148828242 5227659 complement(1675971..1676744) 1 NC_009567.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; CTP synthetase 1676744 5227659 CGSHiGG_09040 Haemophilus influenzae PittGG CTP synthetase YP_001292995.1 1675971 R 374931 CDS YP_001292996.1 148828243 5227660 complement(1677045..1678319) 1 NC_009567.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1678319 5227660 CGSHiGG_09045 Haemophilus influenzae PittGG UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_001292996.1 1677045 R 374931 CDS YP_001292997.1 148828244 5227661 complement(1678329..1678586) 1 NC_009567.1 COG5007 Predicted transcriptional regulator, BolA superfamily; BolA superfamily transcriptional regulator protein 1678586 5227661 CGSHiGG_09050 Haemophilus influenzae PittGG BolA superfamily transcriptional regulator protein YP_001292997.1 1678329 R 374931 CDS YP_001292998.1 148828245 5227662 complement(1678607..1678924) 1 NC_009567.1 COG3113 Predicted NTP binding protein (contains STAS domain); NTP binding protein, contains STAS domain 1678924 5227662 CGSHiGG_09055 Haemophilus influenzae PittGG NTP binding protein, contains STAS domain YP_001292998.1 1678607 R 374931 CDS YP_001292999.1 148828246 5227663 complement(1678935..1679579) 1 NC_009567.1 COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component; ABC transporter 1679579 5227663 CGSHiGG_09060 Haemophilus influenzae PittGG ABC transporter YP_001292999.1 1678935 R 374931 CDS YP_001293000.1 148828247 5227664 complement(1679612..1680112) 1 NC_009567.1 COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component; ABC transporter periplasmic protein 1680112 5227664 CGSHiGG_09065 Haemophilus influenzae PittGG ABC transporter periplasmic protein YP_001293000.1 1679612 R 374931 CDS YP_001293001.1 148828248 5227665 complement(1680122..1680907) 1 NC_009567.1 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component; ABC transporter permease 1680907 5227665 CGSHiGG_09070 Haemophilus influenzae PittGG ABC transporter permease YP_001293001.1 1680122 R 374931 CDS YP_001293002.1 148828249 5227666 complement(1680904..1681698) 1 NC_009567.1 COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component; ABC transporter ATPase 1681698 5227666 CGSHiGG_09075 Haemophilus influenzae PittGG ABC transporter ATPase YP_001293002.1 1680904 R 374931 CDS YP_001293003.1 148828250 5227667 complement(1682117..1682752) 1 NC_009567.1 COG0605 Superoxide dismutase; superoxide dismutase (Mn) 1682752 5227667 CGSHiGG_09080 Haemophilus influenzae PittGG superoxide dismutase (Mn) YP_001293003.1 1682117 R 374931 CDS YP_001293004.1 148828251 5227668 1683001..1683639 1 NC_009567.1 ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 1683639 5227668 CGSHiGG_09085 Haemophilus influenzae PittGG cytochrome c biogenesis protein CcmA YP_001293004.1 1683001 D 374931 CDS YP_001293005.1 148828252 5227669 1683644..1684309 1 NC_009567.1 COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component; heme exporter protein B 1684309 5227669 CGSHiGG_09090 Haemophilus influenzae PittGG heme exporter protein B YP_001293005.1 1683644 D 374931 CDS YP_001293006.1 148828253 5227670 1684370..1685110 1 NC_009567.1 COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component; heme exporter protein C 1685110 5227670 CGSHiGG_09095 Haemophilus influenzae PittGG heme exporter protein C YP_001293006.1 1684370 D 374931 CDS YP_001293007.1 148828254 5227671 1685152..1685355 1 NC_009567.1 COG3114 Heme exporter protein D; heme exporter protein D 1685355 5227671 CGSHiGG_09100 Haemophilus influenzae PittGG heme exporter protein D YP_001293007.1 1685152 D 374931 CDS YP_001293008.1 148828255 5227672 1685352..1685873 1 NC_009567.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 1685873 5227672 CGSHiGG_09105 Haemophilus influenzae PittGG cytochrome c-type biogenesis protein CcmE YP_001293008.1 1685352 D 374931 CDS YP_001293009.1 148828256 5227673 1687930..1688475 1 NC_009567.1 COG0526 Thiol-disulfide isomerase and thioredoxins; thiol-disulfide interchange protein 1688475 5227673 CGSHiGG_09120 Haemophilus influenzae PittGG thiol-disulfide interchange protein YP_001293009.1 1687930 D 374931 CDS YP_001293010.1 148828257 5227674 1688475..1688936 1 NC_009567.1 COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes; cytochrome C-type biogenesis protein 1688936 5227674 CGSHiGG_09125 Haemophilus influenzae PittGG cytochrome C-type biogenesis protein YP_001293010.1 1688475 D 374931 CDS YP_001293011.1 148828258 5227675 1688937..1689854 1 NC_009567.1 TPR repeat-containing protein 1689854 5227675 CGSHiGG_09130 Haemophilus influenzae PittGG TPR repeat-containing protein YP_001293011.1 1688937 D 374931 CDS YP_001293012.1 148828259 5227676 1689975..1690115 1 NC_009567.1 hypothetical protein 1690115 5227676 CGSHiGG_09135 Haemophilus influenzae PittGG hypothetical protein YP_001293012.1 1689975 D 374931 CDS YP_001293013.1 148828260 5227677 1690289..1690474 1 NC_009567.1 hypothetical protein 1690474 5227677 CGSHiGG_09140 Haemophilus influenzae PittGG hypothetical protein YP_001293013.1 1690289 D 374931 CDS YP_001293014.1 148828261 5227678 1690485..1690784 1 NC_009567.1 COG4235 Cytochrome c biogenesis factor; hypothetical protein 1690784 5227678 CGSHiGG_09145 Haemophilus influenzae PittGG hypothetical protein YP_001293014.1 1690485 D 374931 CDS YP_001293015.1 148828262 5227679 complement(1690789..1692801) 1 NC_009567.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 1692801 ligA 5227679 ligA Haemophilus influenzae PittGG NAD-dependent DNA ligase LigA YP_001293015.1 1690789 R 374931 CDS YP_001293016.1 148828263 5227680 complement(1692913..1693899) 1 NC_009567.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA 1693899 5227680 CGSHiGG_09155 Haemophilus influenzae PittGG cell division protein ZipA YP_001293016.1 1692913 R 374931 CDS YP_001293017.1 148828264 5227681 1694052..1694870 1 NC_009567.1 putative role in sulfur assimilation; putative sulfate transport protein CysZ 1694870 5227681 CGSHiGG_09160 Haemophilus influenzae PittGG putative sulfate transport protein CysZ YP_001293017.1 1694052 D 374931 CDS YP_001293018.1 148828265 5227682 1694969..1695919 1 NC_009567.1 COG0031 Cysteine synthase; cysteine synthase 1695919 5227682 CGSHiGG_09165 Haemophilus influenzae PittGG cysteine synthase YP_001293018.1 1694969 D 374931 CDS YP_001293019.1 148828266 5227683 1696167..1697390 1 NC_009567.1 COG0477 Permeases of the major facilitator superfamily; transporter protein 1697390 5227683 CGSHiGG_09170 Haemophilus influenzae PittGG transporter protein YP_001293019.1 1696167 D 374931 CDS YP_001293020.1 148828267 5227684 complement(1697590..1698540) 1 NC_009567.1 COG0859 ADP-heptose:LPS heptosyltransferase; ADP-heptose-LPS heptosyltransferase II 1698540 5227684 CGSHiGG_09175 Haemophilus influenzae PittGG ADP-heptose-LPS heptosyltransferase II YP_001293020.1 1697590 R 374931 CDS YP_001293021.1 148828268 5227685 complement(1698616..1699779) 1 NC_009567.1 COG1609 Transcriptional regulators; xylose operon regulatory protein 1699779 5227685 CGSHiGG_09180 Haemophilus influenzae PittGG xylose operon regulatory protein YP_001293021.1 1698616 R 374931 CDS YP_001293022.1 148828269 5227686 complement(1701298..1702470) 1 NC_009567.1 COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; putative aspartate aminotransferase 1702470 5227686 CGSHiGG_09195 Haemophilus influenzae PittGG putative aspartate aminotransferase YP_001293022.1 1701298 R 374931 CDS YP_001293023.1 148828270 5227687 complement(1702746..1703873) 1 NC_009567.1 COG4214 ABC-type xylose transport system, permease component; D-xylose ABC transporter permease protein 1703873 5227687 CGSHiGG_09200 Haemophilus influenzae PittGG D-xylose ABC transporter permease protein YP_001293023.1 1702746 R 374931 CDS YP_001293024.1 148828271 5227688 complement(1703877..1705388) 1 NC_009567.1 with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit 1705388 5227688 CGSHiGG_09205 Haemophilus influenzae PittGG xylose transporter ATP-binding subunit YP_001293024.1 1703877 R 374931 CDS YP_001293025.1 148828272 5227689 complement(1705439..1706437) 1 NC_009567.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 1706437 xylF 5227689 xylF Haemophilus influenzae PittGG D-xylose transporter subunit XylF YP_001293025.1 1705439 R 374931 CDS YP_001293026.1 148828273 5227690 1706671..1707990 1 NC_009567.1 catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase 1707990 5227690 CGSHiGG_09215 Haemophilus influenzae PittGG xylose isomerase YP_001293026.1 1706671 D 374931 CDS YP_001293027.1 148828274 5227691 1708047..1709525 1 NC_009567.1 COG1070 Sugar (pentulose and hexulose) kinases; xylose isomerase 1709525 5227691 CGSHiGG_09220 Haemophilus influenzae PittGG xylose isomerase YP_001293027.1 1708047 D 374931 CDS YP_001293028.1 148828275 5227692 complement(1709576..1710502) 1 NC_009567.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-mannoheptose-6-epimerase 1710502 rfaD 5227692 rfaD Haemophilus influenzae PittGG ADP-L-glycero-D-mannoheptose-6-epimerase YP_001293028.1 1709576 R 374931 CDS YP_001293029.1 148828276 5227693 complement(1710555..1711034) 1 NC_009567.1 COG0526 Thiol-disulfide isomerase and thioredoxins; ADP-L-glycero-D-mannoheptose-6-epimerase 1711034 rfaD 5227693 rfaD Haemophilus influenzae PittGG ADP-L-glycero-D-mannoheptose-6-epimerase YP_001293029.1 1710555 R 374931 CDS YP_001293030.1 148828277 5227694 complement(1711874..1713403) 1 NC_009567.1 COG0606 Predicted ATPase with chaperone activity; deoxyribose-phosphate aldolase 1713403 5227694 CGSHiGG_09245 Haemophilus influenzae PittGG deoxyribose-phosphate aldolase YP_001293030.1 1711874 R 374931 CDS YP_001293031.1 148828278 5227695 complement(1713518..1714135) 1 NC_009567.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 1714135 engB 5227695 engB Haemophilus influenzae PittGG ribosome biogenesis GTP-binding protein YsxC YP_001293031.1 1713518 R 374931 CDS YP_001293032.1 148828279 5227696 1714174..1715106 1 NC_009567.1 COG2990 Uncharacterized protein conserved in bacteria; D-xylose transport permease protein 1715106 5227696 CGSHiGG_09255 Haemophilus influenzae PittGG D-xylose transport permease protein YP_001293032.1 1714174 D 374931 CDS YP_001293033.1 148828280 5227697 complement(1715146..1716144) 1 NC_009567.1 COG4608 ABC-type oligopeptide transport system, ATPase component; GTPase EngB 1716144 5227697 CGSHiGG_09260 Haemophilus influenzae PittGG GTPase EngB YP_001293033.1 1715146 R 374931 CDS YP_001293034.1 148828281 5227698 complement(1716141..1717112) 1 NC_009567.1 COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component; oligopeptide transporter ATP-binding protein 1717112 oppD 5227698 oppD Haemophilus influenzae PittGG oligopeptide transporter ATP-binding protein YP_001293034.1 1716141 R 374931 CDS YP_001293035.1 148828282 5227699 complement(1717122..1718057) 1 NC_009567.1 COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; oligopeptide transporter ATP-binding protein 1718057 oppD 5227699 oppD Haemophilus influenzae PittGG oligopeptide transporter ATP-binding protein YP_001293035.1 1717122 R 374931 CDS YP_001293036.1 148828283 5227700 complement(1718067..1718909) 1 NC_009567.1 COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; oligopeptide transporter permease 1718909 oppB 5227700 oppB Haemophilus influenzae PittGG oligopeptide transporter permease YP_001293036.1 1718067 R 374931 CDS YP_001293037.1 148828284 5227701 complement(1719069..1720694) 1 NC_009567.1 COG4166 ABC-type oligopeptide transport system, periplasmic component; oligopeptide permease ABC transporter membrane protein 1720694 oppB 5227701 oppB Haemophilus influenzae PittGG oligopeptide permease ABC transporter membrane protein YP_001293037.1 1719069 R 374931 CDS YP_001293038.1 148828285 5227702 1720988..1721941 1 NC_009567.1 COG0176 Transaldolase; transaldolase B 1721941 5227702 CGSHiGG_09285 Haemophilus influenzae PittGG transaldolase B YP_001293038.1 1720988 D 374931 CDS YP_001293039.1 148828286 5227703 complement(1722590..1722820) 1 NC_009567.1 COG0777 Acetyl-CoA carboxylase beta subunit; hypothetical protein 1722820 5227703 CGSHiGG_09290 Haemophilus influenzae PittGG hypothetical protein YP_001293039.1 1722590 R 374931 CDS YP_001293040.1 148828287 5227704 1723017..1724603 1 NC_009567.1 COG1966 Carbon starvation protein, predicted membrane protein; transaldolase B 1724603 5227704 CGSHiGG_09295 Haemophilus influenzae PittGG transaldolase B YP_001293040.1 1723017 D 374931 CDS YP_001293041.1 148828288 5227705 1724815..1725270 1 NC_009567.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 1725270 5227705 CGSHiGG_09300 Haemophilus influenzae PittGG cell division protein MraZ YP_001293041.1 1724815 D 374931 CDS YP_001293042.1 148828289 5227706 1725301..1726170 1 NC_009567.1 COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis; S-adenosyl-methyltransferase MraW 1726170 mraW 5227706 mraW Haemophilus influenzae PittGG S-adenosyl-methyltransferase MraW YP_001293042.1 1725301 D 374931 CDS YP_001293043.1 148828290 5227707 1726134..1726265 1 NC_009567.1 COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis; S-adenosyl-methyltransferase 1726265 5227707 CGSHiGG_09310 Haemophilus influenzae PittGG S-adenosyl-methyltransferase YP_001293043.1 1726134 D 374931 CDS YP_001293044.1 148828291 5227708 1726268..1726591 1 NC_009567.1 COG3116 Cell division protein; cell division protein FtsL 1726591 5227708 CGSHiGG_09315 Haemophilus influenzae PittGG cell division protein FtsL YP_001293044.1 1726268 D 374931 CDS YP_001293045.1 148828292 5227709 1726603..1728435 1 NC_009567.1 COG0768 Cell division protein FtsI/penicillin-binding protein 2; S-adenosyl-methyltransferase MraW 1728435 mraW 5227709 mraW Haemophilus influenzae PittGG S-adenosyl-methyltransferase MraW YP_001293045.1 1726603 D 374931 CDS YP_001293046.1 148828293 5227710 1728445..1729911 1 NC_009567.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1729911 murE 5227710 murE Haemophilus influenzae PittGG UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_001293046.1 1728445 D 374931 CDS YP_001293047.1 148828294 5227711 1729925..1731298 1 NC_009567.1 COG0770 UDP-N-acetylmuramyl pentapeptide synthase; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1731298 murE 5227711 murE Haemophilus influenzae PittGG UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_001293047.1 1729925 D 374931 CDS YP_001293048.1 148828295 5227712 1731292..1732374 1 NC_009567.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 1732374 mraY 5227712 mraY Haemophilus influenzae PittGG phospho-N-acetylmuramoyl-pentapeptide- transferase YP_001293048.1 1731292 D 374931 CDS YP_001293049.1 148828296 5227713 1732486..1733799 1 NC_009567.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 1733799 murD 5227713 murD Haemophilus influenzae PittGG UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_001293049.1 1732486 D 374931 CDS YP_001293050.1 148828297 5227714 1733822..1735006 1 NC_009567.1 COG0772 Bacterial cell division membrane protein; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 1735006 murD 5227714 murD Haemophilus influenzae PittGG UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_001293050.1 1733822 D 374931 CDS YP_001293051.1 148828298 5227715 1735018..1736073 1 NC_009567.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 1736073 murG 5227715 murG Haemophilus influenzae PittGG undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_001293051.1 1735018 D 374931 CDS YP_001293052.1 148828299 5227716 1736211..1737638 1 NC_009567.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 1737638 murC 5227716 murC Haemophilus influenzae PittGG UDP-N-acetylmuramate--L-alanine ligase YP_001293052.1 1736211 D 374931 CDS YP_001293053.1 148828300 5227717 1737710..1738630 1 NC_009567.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 1738630 ddl 5227717 ddl Haemophilus influenzae PittGG D-alanine--D-alanine ligase YP_001293053.1 1737710 D 374931 CDS YP_001293054.1 148828301 5227718 1738630..1739337 1 NC_009567.1 COG1589 Cell division septal protein; cell division protein 1739337 5227718 CGSHiGG_09365 Haemophilus influenzae PittGG cell division protein YP_001293054.1 1738630 D 374931 CDS YP_001293055.1 148828302 5227719 1739412..1740689 1 NC_009567.1 COG0849 Actin-like ATPase involved in cell division; D-alanine--D-alanine ligase 1740689 ddl 5227719 ddl Haemophilus influenzae PittGG D-alanine--D-alanine ligase YP_001293055.1 1739412 D 374931 CDS YP_001293056.1 148828303 5227720 1740774..1742051 1 NC_009567.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1742051 5227720 CGSHiGG_09375 Haemophilus influenzae PittGG cell division protein FtsZ YP_001293056.1 1740774 D 374931 CDS YP_001293057.1 148828304 5227721 1742090..1743007 1 NC_009567.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 1743007 lpxC 5227721 lpxC Haemophilus influenzae PittGG UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_001293057.1 1742090 D 374931 CDS YP_001293058.1 148828305 5227722 1743134..1744291 1 NC_009567.1 COG1605 Chorismate mutase; cell division protein FtsZ 1744291 5227722 CGSHiGG_09385 Haemophilus influenzae PittGG cell division protein FtsZ YP_001293058.1 1743134 D 374931 CDS YP_001293059.1 148828306 5227723 complement(1745210..1745704) 1 NC_009567.1 COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); nitrogen regulatory IIA protein 1745704 5227723 CGSHiGG_09400 Haemophilus influenzae PittGG nitrogen regulatory IIA protein YP_001293059.1 1745210 R 374931 CDS YP_001293060.1 148828307 5227724 complement(1745707..1746432) 1 NC_009567.1 COG1137 ABC-type (unclassified) transport system, ATPase component; ABC transporter ATP-binding protein 1746432 5227724 CGSHiGG_09405 Haemophilus influenzae PittGG ABC transporter ATP-binding protein YP_001293060.1 1745707 R 374931 CDS YP_001293061.1 148828308 5227725 complement(1746436..1746954) 1 NC_009567.1 COG1934 Uncharacterized protein conserved in bacteria; hypothetical protein 1746954 5227725 CGSHiGG_09410 Haemophilus influenzae PittGG hypothetical protein YP_001293061.1 1746436 R 374931 CDS YP_001293062.1 148828309 5227726 complement(1746935..1747549) 1 NC_009567.1 COG3117 Uncharacterized protein conserved in bacteria; hypothetical protein 1747549 5227726 CGSHiGG_09415 Haemophilus influenzae PittGG hypothetical protein YP_001293062.1 1746935 R 374931 CDS YP_001293063.1 148828310 5227727 complement(1747600..1748136) 1 NC_009567.1 COG3028 Uncharacterized protein conserved in bacteria; hypothetical protein 1748136 5227727 CGSHiGG_09420 Haemophilus influenzae PittGG hypothetical protein YP_001293063.1 1747600 R 374931 CDS YP_001293064.1 148828311 5227728 1749791..1750330 1 NC_009567.1 COG0634 Hypoxanthine-guanine phosphoribosyltransferase; hypoxanthine-guanine phosphoribosyltransferase 1750330 5227728 CGSHiGG_09435 Haemophilus influenzae PittGG hypoxanthine-guanine phosphoribosyltransferase YP_001293064.1 1749791 D 374931 CDS YP_001293065.1 148828312 5227729 1750332..1750541 1 NC_009567.1 COG1280 Putative threonine efflux protein; hypothetical protein 1750541 5227729 CGSHiGG_09440 Haemophilus influenzae PittGG hypothetical protein YP_001293065.1 1750332 D 374931 CDS YP_001293066.1 148828313 5227730 1750623..1751957 1 NC_009567.1 COG1823 Predicted Na+/dicarboxylate symporter; hypothetical protein 1751957 5227730 CGSHiGG_09445 Haemophilus influenzae PittGG hypothetical protein YP_001293066.1 1750623 D 374931 CDS YP_001293067.1 148828314 5227731 complement(1752057..1752524) 1 NC_009567.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein 1752524 nrdG 5227731 nrdG Haemophilus influenzae PittGG anaerobic ribonucleotide reductase-activating protein YP_001293067.1 1752057 R 374931 CDS YP_001293068.1 148828315 5227732 complement(1754573..1756264) 1 NC_009567.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component 1756264 5227732 CGSHiGG_09465 Haemophilus influenzae PittGG cysteine/glutathione ABC transporter membrane/ATP-binding component YP_001293068.1 1754573 R 374931 CDS YP_001293069.1 148828316 5227733 complement(1757365..1758222) 1 NC_009567.1 COG3118 Thioredoxin domain-containing protein; thioredoxin domain-containing protein 1758222 5227733 CGSHiGG_09480 Haemophilus influenzae PittGG thioredoxin domain-containing protein YP_001293069.1 1757365 R 374931 CDS YP_001293070.1 148828317 5227734 complement(1759271..1759687) 1 NC_009567.1 COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; hypothetical protein 1759687 5227734 CGSHiGG_09495 Haemophilus influenzae PittGG hypothetical protein YP_001293070.1 1759271 R 374931 CDS YP_001293071.1 148828318 5227735 complement(1759729..1760109) 1 NC_009567.1 COG2852 Uncharacterized protein conserved in bacteria; hypothetical protein 1760109 5227735 CGSHiGG_09500 Haemophilus influenzae PittGG hypothetical protein YP_001293071.1 1759729 R 374931 CDS YP_001293072.1 148828319 5227736 complement(1760187..1763270) 1 NC_009567.1 COG0277 FAD/FMN-containing dehydrogenases; hypothetical protein 1763270 5227736 CGSHiGG_09505 Haemophilus influenzae PittGG hypothetical protein YP_001293072.1 1760187 R 374931 CDS YP_001293073.1 148828320 5227737 1764859..1765182 1 NC_009567.1 COG0278 Glutaredoxin-related protein; ferrochelatase 1765182 hemH 5227737 hemH Haemophilus influenzae PittGG ferrochelatase YP_001293073.1 1764859 D 374931 CDS YP_001293074.1 148828321 5227738 complement(1766446..1767534) 1 NC_009567.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 1767534 5227738 CGSHiGG_09535 Haemophilus influenzae PittGG phosphoserine aminotransferase YP_001293074.1 1766446 R 374931 CDS YP_001293075.1 148828322 5227739 1767725..1768069 1 NC_009567.1 COG2926 Uncharacterized protein conserved in bacteria; hypothetical protein 1768069 5227739 CGSHiGG_09540 Haemophilus influenzae PittGG hypothetical protein YP_001293075.1 1767725 D 374931 CDS YP_001293076.1 148828323 5227740 complement(1768110..1768676) 1 NC_009567.1 COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; hypothetical protein 1768676 5227740 CGSHiGG_09545 Haemophilus influenzae PittGG hypothetical protein YP_001293076.1 1768110 R 374931 CDS YP_001293077.1 148828324 5227741 complement(1768676..1769647) 1 NC_009567.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; para-aminobenzoate synthase component I 1769647 5227741 CGSHiGG_09550 Haemophilus influenzae PittGG para-aminobenzoate synthase component I YP_001293077.1 1768676 R 374931 CDS YP_001293078.1 148828325 5227742 1769704..1770285 1 NC_009567.1 catalyzes the formation of anthranilate from chorismate and glutamine; functions in tryptophan biosynthesis; putative anthranilate synthase component II 1770285 5227742 CGSHiGG_09555 Haemophilus influenzae PittGG putative anthranilate synthase component II YP_001293078.1 1769704 D 374931 CDS YP_001293079.1 148828326 5227743 1770370..1771524 1 NC_009567.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1771524 5227743 CGSHiGG_09560 Haemophilus influenzae PittGG S-adenosylmethionine synthetase YP_001293079.1 1770370 D 374931 CDS YP_001293080.1 148828327 5227744 1772015..1772335 1 NC_009567.1 COG3091 Uncharacterized protein conserved in bacteria; hypothetical protein 1772335 5227744 CGSHiGG_09565 Haemophilus influenzae PittGG hypothetical protein YP_001293080.1 1772015 D 374931 CDS YP_001293081.1 148828328 5227745 1772386..1772898 1 NC_009567.1 COG3637 Opacity protein and related surface antigens; opacity protein 1772898 5227745 CGSHiGG_09570 Haemophilus influenzae PittGG opacity protein YP_001293081.1 1772386 D 374931 CDS YP_001293082.1 148828329 5227746 complement(1772996..1773496) 1 NC_009567.1 COG5295 Autotransporter adhesin; hypothetical protein 1773496 5227746 CGSHiGG_09575 Haemophilus influenzae PittGG hypothetical protein YP_001293082.1 1772996 R 374931 CDS YP_001293083.1 148828330 5227747 complement(1773515..1774198) 1 NC_009567.1 with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM 1774198 artM 5227747 artM Haemophilus influenzae PittGG arginine transporter permease subunit ArtM YP_001293083.1 1773515 R 374931 CDS YP_001293084.1 148828331 5227748 complement(1774198..1774863) 1 NC_009567.1 with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ 1774863 5227748 CGSHiGG_09585 Haemophilus influenzae PittGG arginine transporter permease subunit ArtQ YP_001293084.1 1774198 R 374931 CDS YP_001293085.1 148828332 5227749 complement(1774867..1775586) 1 NC_009567.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; arginine transporter permease subunit ArtQ 1775586 5227749 CGSHiGG_09590 Haemophilus influenzae PittGG arginine transporter permease subunit ArtQ YP_001293085.1 1774867 R 374931 CDS YP_001293086.1 148828333 5227750 complement(1775603..1776334) 1 NC_009567.1 With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit 1776334 artP 5227750 artP Haemophilus influenzae PittGG arginine transporter ATP-binding subunit YP_001293086.1 1775603 R 374931 CDS YP_001293087.1 148828334 5227751 complement(1776461..1777045) 1 NC_009567.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 1777045 gmhA 5227751 gmhA Haemophilus influenzae PittGG phosphoheptose isomerase YP_001293087.1 1776461 R 374931 CDS YP_001293088.1 148828335 5227752 1777363..1778058 1 NC_009567.1 catalyzes the formation of a phosphodiester at the site of a single-strand break in duplex DNA; DNA ligase 1778058 5227752 CGSHiGG_09605 Haemophilus influenzae PittGG DNA ligase YP_001293088.1 1777363 D 374931 CDS YP_001293089.1 148828336 5227753 complement(1778087..1779070) 1 NC_009567.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit 1779070 dppF 5227753 dppF Haemophilus influenzae PittGG dipeptide transporter ATP-binding subunit YP_001293089.1 1778087 R 374931 CDS YP_001293090.1 148828337 5227754 complement(1779073..1780065) 1 NC_009567.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit 1780065 dppD 5227754 dppD Haemophilus influenzae PittGG dipeptide transporter ATP-binding subunit YP_001293090.1 1779073 R 374931 CDS YP_001293091.1 148828338 5227755 complement(1780976..1781977) 1 NC_009567.1 COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; dipeptide transporter ATP-binding protein 1781977 dppD 5227755 dppD Haemophilus influenzae PittGG dipeptide transporter ATP-binding protein YP_001293091.1 1780976 R 374931 CDS YP_001293092.1 148828339 5227756 complement(1782065..1784245) 1 NC_009567.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 1784245 uvrD 5227756 uvrD Haemophilus influenzae PittGG DNA-dependent helicase II YP_001293092.1 1782065 R 374931 CDS YP_001293093.1 148828340 5227757 complement(1784232..1784465) 1 NC_009567.1 COG0210 Superfamily I DNA and RNA helicases; hypothetical protein 1784465 5227757 CGSHiGG_09640 Haemophilus influenzae PittGG hypothetical protein YP_001293093.1 1784232 R 374931 CDS YP_001293094.1 148828341 5227758 complement(1785496..1785921) 1 NC_009567.1 COG0720 6-pyruvoyl-tetrahydropterin synthase; 6-pyruvoyl tetrahydrobiopterin synthase 1785921 5227758 CGSHiGG_09655 Haemophilus influenzae PittGG 6-pyruvoyl tetrahydrobiopterin synthase YP_001293094.1 1785496 R 374931 CDS YP_001293095.1 148828342 5227759 1786753..1786896 1 NC_009567.1 COG0603 Predicted PP-loop superfamily ATPase; hypothetical protein 1786896 uvrD 5227759 uvrD Haemophilus influenzae PittGG hypothetical protein YP_001293095.1 1786753 D 374931 CDS YP_001293096.1 148828343 5227760 complement(1786947..1787978) 1 NC_009567.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 1787978 5227760 CGSHiGG_09675 Haemophilus influenzae PittGG branched-chain amino acid aminotransferase YP_001293096.1 1786947 R 374931 CDS YP_001293097.1 148828344 5227761 1788452..1789345 1 NC_009567.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA 1789345 5227761 CGSHiGG_09680 Haemophilus influenzae PittGG DNA-binding transcriptional activator GcvA YP_001293097.1 1788452 D 374931 CDS YP_001293098.1 148828345 5227762 1789338..1790429 1 NC_009567.1 COG2933 Predicted SAM-dependent methyltransferase; putative RNA 2'-O-ribose methyltransferase 1790429 5227762 CGSHiGG_09685 Haemophilus influenzae PittGG putative RNA 2'-O-ribose methyltransferase YP_001293098.1 1789338 D 374931 CDS YP_001293099.1 148828346 5227763 1790465..1791649 1 NC_009567.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 1791649 5227763 CGSHiGG_09690 Haemophilus influenzae PittGG succinyl-CoA synthetase subunit beta YP_001293099.1 1790465 D 374931 CDS YP_001293100.1 148828347 5227764 complement(1792510..1792635) 1 NC_009567.1 COG0074 Succinyl-CoA synthetase, alpha subunit; hypothetical protein 1792635 5227764 CGSHiGG_09705 Haemophilus influenzae PittGG hypothetical protein YP_001293100.1 1792510 R 374931 CDS YP_001293101.1 148828348 5227765 1792634..1793257 1 NC_009567.1 COG0009 Putative translation factor (SUA5); hypothetical protein 1793257 5227765 CGSHiGG_09710 Haemophilus influenzae PittGG hypothetical protein YP_001293101.1 1792634 D 374931 CDS YP_001293102.1 148828349 5227766 1793305..1794378 1 NC_009567.1 COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; methyltransferase 1794378 5227766 CGSHiGG_09715 Haemophilus influenzae PittGG methyltransferase YP_001293102.1 1793305 D 374931 CDS YP_001293103.1 148828350 5227767 1794389..1795360 1 NC_009567.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1795360 cysB 5227767 cysB Haemophilus influenzae PittGG transcriptional regulator CysB YP_001293103.1 1794389 D 374931 CDS YP_001293104.1 148828351 5227768 complement(1795419..1796363) 1 NC_009567.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1796363 5227768 CGSHiGG_09725 Haemophilus influenzae PittGG N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_001293104.1 1795419 R 374931 CDS YP_001293105.1 148828352 5227769 1796494..1796997 1 NC_009567.1 COG2840 Uncharacterized protein conserved in bacteria; hypothetical protein 1796997 5227769 CGSHiGG_09730 Haemophilus influenzae PittGG hypothetical protein YP_001293105.1 1796494 D 374931 CDS YP_001293106.1 148828353 5227770 complement(1797074..1799209) 1 NC_009567.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 1799209 5227770 CGSHiGG_09735 Haemophilus influenzae PittGG phosphate acetyltransferase YP_001293106.1 1797074 R 374931 CDS YP_001293107.1 148828354 5227771 complement(1799277..1800482) 1 NC_009567.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 1800482 5227771 CGSHiGG_09740 Haemophilus influenzae PittGG acetate kinase YP_001293107.1 1799277 R 374931 CDS YP_001293108.1 148828355 5227772 1801228..1801719 1 NC_009567.1 COG1286 Uncharacterized membrane protein, required for colicin V production; hypothetical protein 1801719 5227772 CGSHiGG_09755 Haemophilus influenzae PittGG hypothetical protein YP_001293108.1 1801228 D 374931 CDS YP_001293109.1 148828356 5227773 1801730..1803247 1 NC_009567.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 1803247 5227773 CGSHiGG_09760 Haemophilus influenzae PittGG amidophosphoribosyltransferase YP_001293109.1 1801730 D 374931 CDS YP_001293110.1 148828357 5227774 complement(1803302..1804192) 1 NC_009567.1 COG1090 Predicted nucleoside-diphosphate sugar epimerase; amidophosphoribosyltransferase 1804192 5227774 CGSHiGG_09765 Haemophilus influenzae PittGG amidophosphoribosyltransferase YP_001293110.1 1803302 R 374931 CDS YP_001293111.1 148828358 5227775 complement(1804192..1804647) 1 NC_009567.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 1804647 5227775 CGSHiGG_09770 Haemophilus influenzae PittGG arginine repressor YP_001293111.1 1804192 R 374931 CDS YP_001293112.1 148828359 5227776 1804854..1805789 1 NC_009567.1 oxidizes malate to oxaloacetate; malate dehydrogenase 1805789 5227776 CGSHiGG_09775 Haemophilus influenzae PittGG malate dehydrogenase YP_001293112.1 1804854 D 374931 CDS YP_001293113.1 148828360 5227777 complement(1805876..1807384) 1 NC_009567.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 1807384 lysS 5227777 lysS Haemophilus influenzae PittGG lysyl-tRNA synthetase YP_001293113.1 1805876 R 374931 CDS YP_001293114.1 148828361 5227778 complement(1807537..1808283) 1 NC_009567.1 COG1186 Protein chain release factor B; peptide chain release factor 2 1808283 5227778 CGSHiGG_09785 Haemophilus influenzae PittGG peptide chain release factor 2 YP_001293114.1 1807537 R 374931 CDS YP_001293115.1 148828362 5227779 1808768..1809457 1 NC_009567.1 COG1651 Protein-disulfide isomerase; thiol-disulfide interchange protein 1809457 5227779 CGSHiGG_09790 Haemophilus influenzae PittGG thiol-disulfide interchange protein YP_001293115.1 1808768 D 374931 CDS YP_001293116.1 148828363 5227780 1811480..1812133 1 NC_009567.1 COG0526 Thiol-disulfide isomerase and thioredoxins; lysyl-tRNA synthetase 1812133 lysS 5227780 lysS Haemophilus influenzae PittGG lysyl-tRNA synthetase YP_001293116.1 1811480 D 374931 CDS YP_001293117.1 148828364 5227781 1812171..1812860 1 NC_009567.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1812860 5227781 CGSHiGG_09810 Haemophilus influenzae PittGG 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_001293117.1 1812171 D 374931 CDS YP_001293118.1 148828365 5227782 complement(1815995..1817593) 1 NC_009567.1 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1817593 5227782 CGSHiGG_09830 Haemophilus influenzae PittGG 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_001293118.1 1815995 R 374931 CDS YP_001293119.1 148828366 5227783 1817867..1817962 1 NC_009567.1 COG1620 L-lactate permease; cytidylate kinase 1817962 cmk 5227783 cmk Haemophilus influenzae PittGG cytidylate kinase YP_001293119.1 1817867 D 374931 CDS YP_001293120.1 148828367 5227784 1819057..1819191 1 NC_009567.1 COG0158 Fructose-1,6-bisphosphatase; hypothetical protein 1819191 5227784 CGSHiGG_09850 Haemophilus influenzae PittGG hypothetical protein YP_001293120.1 1819057 D 374931 CDS YP_001293121.1 148828368 5227785 1819237..1820046 1 NC_009567.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1820046 truA 5227785 truA Haemophilus influenzae PittGG tRNA pseudouridine synthase A YP_001293121.1 1819237 D 374931 CDS YP_001293122.1 148828369 5227786 complement(1820139..1821155) 1 NC_009567.1 COG2855 Predicted membrane protein; hypothetical protein 1821155 5227786 CGSHiGG_09860 Haemophilus influenzae PittGG hypothetical protein YP_001293122.1 1820139 R 374931 CDS YP_001293123.1 148828370 5227787 complement(1821167..1821976) 1 NC_009567.1 COG4167 ABC-type antimicrobial peptide transport system, ATPase component; anti peptide resistance ABC transporter ATPase 1821976 5227787 CGSHiGG_09865 Haemophilus influenzae PittGG anti peptide resistance ABC transporter ATPase YP_001293123.1 1821167 R 374931 CDS YP_001293124.1 148828371 5227788 complement(1821976..1823025) 1 NC_009567.1 COG4170 ABC-type antimicrobial peptide transport system, ATPase component; peptide ABC transporter ATP-binding protein 1823025 5227788 CGSHiGG_09870 Haemophilus influenzae PittGG peptide ABC transporter ATP-binding protein YP_001293124.1 1821976 R 374931 CDS YP_001293125.1 148828372 5227789 complement(1823069..1823917) 1 NC_009567.1 COG4171 ABC-type antimicrobial peptide transport system, permease component; peptide ABC transporter permease protein 1823917 5227789 CGSHiGG_09875 Haemophilus influenzae PittGG peptide ABC transporter permease protein YP_001293125.1 1823069 R 374931 CDS YP_001293126.1 148828373 5227790 complement(1824873..1826567) 1 NC_009567.1 COG4166 ABC-type oligopeptide transport system, periplasmic component; anti peptide resistance ABC transporter periplasmic protein 1826567 5227790 CGSHiGG_09890 Haemophilus influenzae PittGG anti peptide resistance ABC transporter periplasmic protein YP_001293126.1 1824873 R 374931 CDS YP_001293127.1 148828374 5227791 1826637..1828049 1 NC_009567.1 COG3106 Predicted ATPase; hypothetical protein 1828049 truA 5227791 truA Haemophilus influenzae PittGG hypothetical protein YP_001293127.1 1826637 D 374931 CDS YP_001293128.1 148828375 5227792 complement(1828087..1830726) 1 NC_009567.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 1830726 5227792 CGSHiGG_09900 Haemophilus influenzae PittGG phosphoenolpyruvate carboxylase YP_001293128.1 1828087 R 374931 CDS YP_001293129.1 148828376 5227793 complement(1830909..1831919) 1 NC_009567.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 1831919 5227793 CGSHiGG_09905 Haemophilus influenzae PittGG DNA-binding transcriptional repressor PurR YP_001293129.1 1830909 R 374931 CDS YP_001293131.1 148828378 5227795 complement(1833165..1834463) 1 NC_009567.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 1834463 5227795 CGSHiGG_09925 Haemophilus influenzae PittGG adenylosuccinate synthetase YP_001293131.1 1833165 R 374931 CDS YP_001293132.1 148828379 5227796 complement(1834592..1834957) 1 NC_009567.1 adenylosuccinate synthetase 1834957 5227796 CGSHiGG_09930 Haemophilus influenzae PittGG adenylosuccinate synthetase YP_001293132.1 1834592 R 374931 CDS YP_001293134.1 148828381 5227798 complement(1835809..1836096) 1 NC_009567.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 1836096 5227798 CGSHiGG_09940 Haemophilus influenzae PittGG 50S ribosomal protein L25 YP_001293134.1 1835809 R 374931 CDS YP_001293135.1 148828382 5227799 1836314..1836919 1 NC_009567.1 COG0586 Uncharacterized membrane-associated protein; membrane-associated protein 1836919 5227799 CGSHiGG_09945 Haemophilus influenzae PittGG membrane-associated protein YP_001293135.1 1836314 D 374931 CDS YP_001293136.1 148828383 5227800 complement(1836966..1837370) 1 NC_009567.1 COG3105 Uncharacterized protein conserved in bacteria; hypothetical protein 1837370 5227800 CGSHiGG_09950 Haemophilus influenzae PittGG hypothetical protein YP_001293136.1 1836966 R 374931 CDS YP_001293137.1 148828384 5227801 complement(1837401..1837751) 1 NC_009567.1 hypothetical protein 1837751 5227801 CGSHiGG_09955 Haemophilus influenzae PittGG hypothetical protein YP_001293137.1 1837401 R 374931 CDS YP_001293138.1 148828385 5227802 1838579..1839121 1 NC_009567.1 COG0790 FOG: TPR repeat, SEL1 subfamily; hypothetical protein 1839121 5227802 CGSHiGG_09970 Haemophilus influenzae PittGG hypothetical protein YP_001293138.1 1838579 D 374931 CDS YP_001293139.1 148828386 5227803 complement(1839135..1839542) 1 NC_009567.1 COG0789 Predicted transcriptional regulators; mercuric resistance operon regulatory protein 1839542 5227803 CGSHiGG_09975 Haemophilus influenzae PittGG mercuric resistance operon regulatory protein YP_001293139.1 1839135 R 374931 CDS YP_001293140.1 148828387 5227804 1839632..1840315 1 NC_009567.1 COG5266 ABC-type Co2+ transport system, periplasmic component; putative ABC-type Co2+ transport system, periplasmic component 1840315 5227804 CGSHiGG_09980 Haemophilus influenzae PittGG putative ABC-type Co2+ transport system, periplasmic component YP_001293140.1 1839632 D 374931 CDS YP_001293141.1 148828388 5227805 1840328..1840813 1 NC_009567.1 COG0013 Alanyl-tRNA synthetase; hypothetical protein 1840813 5227805 CGSHiGG_09985 Haemophilus influenzae PittGG hypothetical protein YP_001293141.1 1840328 D 374931 CDS YP_001293142.1 148828389 5227806 1840813..1841433 1 NC_009567.1 catalyzes the ATP-dependent transport of cobalt; cobalt transport protein CbiM 1841433 5227806 CGSHiGG_09990 Haemophilus influenzae PittGG cobalt transport protein CbiM YP_001293142.1 1840813 D 374931 CDS YP_001293143.1 148828390 5227807 1841433..1842065 1 NC_009567.1 COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters; cobalt ABC transporter permease 1842065 5227807 CGSHiGG_09995 Haemophilus influenzae PittGG cobalt ABC transporter permease YP_001293143.1 1841433 D 374931 CDS YP_001293144.1 148828391 5227808 1842067..1842516 1 NC_009567.1 COG1122 ABC-type cobalt transport system, ATPase component; cobalt transport protein CbiM 1842516 5227808 CGSHiGG_10000 Haemophilus influenzae PittGG cobalt transport protein CbiM YP_001293144.1 1842067 D 374931 CDS YP_001293145.1 148828392 5227809 complement(1842904..1844094) 1 NC_009567.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 1844094 5227809 CGSHiGG_10005 Haemophilus influenzae PittGG aromatic amino acid aminotransferase YP_001293145.1 1842904 R 374931 CDS YP_001293146.1 148828393 5227810 complement(1844234..1845322) 1 NC_009567.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 1845322 5227810 CGSHiGG_10010 Haemophilus influenzae PittGG phosphoribosylaminoimidazole carboxylase ATPase subunit YP_001293146.1 1844234 R 374931 CDS YP_001293147.1 148828394 5227811 complement(1845393..1845728) 1 NC_009567.1 COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; phosphoribosylaminoimidazole carboxylase catalytic subunit 1845728 5227811 CGSHiGG_10015 Haemophilus influenzae PittGG phosphoribosylaminoimidazole carboxylase catalytic subunit YP_001293147.1 1845393 R 374931 CDS YP_001293148.1 148828395 5227812 1846227..1846571 1 NC_009567.1 COG4226 Uncharacterized protein encoded in hypervariable junctions of pilus gene clusters; hypothetical protein 1846571 5227812 CGSHiGG_10020 Haemophilus influenzae PittGG hypothetical protein YP_001293148.1 1846227 D 374931 CDS YP_001293149.1 148828396 5227813 complement(1846712..1847320) 1 NC_009567.1 COG3539 P pilus assembly protein, pilin FimA; putative F17-like fimbrial subunit 1847320 5227813 CGSHiGG_10025 Haemophilus influenzae PittGG putative F17-like fimbrial subunit YP_001293149.1 1846712 R 374931 CDS YP_001293150.1 148828397 5227814 1847861..1848499 1 NC_009567.1 COG3121 P pilus assembly protein, chaperone PapD; putative F17-like fimbrial chaperone 1848499 5227814 CGSHiGG_10030 Haemophilus influenzae PittGG putative F17-like fimbrial chaperone YP_001293150.1 1847861 D 374931 CDS YP_001293151.1 148828398 5227815 1848614..1851127 1 NC_009567.1 COG3188 P pilus assembly protein, porin PapC; putative F17-like fimbrial usher 1851127 5227815 CGSHiGG_10035 Haemophilus influenzae PittGG putative F17-like fimbrial usher YP_001293151.1 1848614 D 374931 CDS YP_001293152.1 148828399 5227816 1851141..1851803 1 NC_009567.1 S-fimbrial protein subunit 1851803 5227816 CGSHiGG_10040 Haemophilus influenzae PittGG S-fimbrial protein subunit YP_001293152.1 1851141 D 374931 CDS YP_001293153.1 148828400 5227817 1851830..1853143 1 NC_009567.1 COG3539 P pilus assembly protein, pilin FimA; hypothetical protein 1853143 5227817 CGSHiGG_10045 Haemophilus influenzae PittGG hypothetical protein YP_001293153.1 1851830 D 374931 CDS YP_001293154.1 148828401 5227818 1853401..1856010 1 NC_009567.1 COG0308 Aminopeptidase N; aminopeptidase N 1856010 pepN 5227818 pepN Haemophilus influenzae PittGG aminopeptidase N YP_001293154.1 1853401 D 374931 CDS YP_001293155.1 148828402 5227819 complement(1856082..1856696) 1 NC_009567.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1856696 5227819 CGSHiGG_10055 Haemophilus influenzae PittGG riboflavin synthase subunit alpha YP_001293155.1 1856082 R 374931 CDS YP_001293156.1 148828403 5227820 1856740..1858134 1 NC_009567.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1858134 5227820 CGSHiGG_10060 Haemophilus influenzae PittGG multidrug efflux protein YP_001293156.1 1856740 D 374931 CDS YP_001293157.1 148828404 5227821 1858143..1858859 1 NC_009567.1 Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A 1858859 5227821 CGSHiGG_10065 Haemophilus influenzae PittGG sugar fermentation stimulation protein A YP_001293157.1 1858143 D 374931 CDS YP_001293158.1 148828405 5227822 1859057..1860244 1 NC_009567.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1860244 5227822 CGSHiGG_10070 Haemophilus influenzae PittGG tyrosyl-tRNA synthetase YP_001293158.1 1859057 D 374931 CDS YP_001293159.1 148828406 5227823 complement(1860327..1861274) 1 NC_009567.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1861274 5227823 CGSHiGG_10075 Haemophilus influenzae PittGG ribose-phosphate pyrophosphokinase YP_001293159.1 1860327 R 374931 CDS YP_001293160.1 148828407 5227825 complement(1861276..1862229) 1 NC_009567.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1862229 ipk 5227825 ipk Haemophilus influenzae PittGG 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_001293160.1 1861276 R 374931 CDS YP_001293161.1 148828408 5227828 complement(1862229..1862849) 1 NC_009567.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB 1862849 lolB 5227828 lolB Haemophilus influenzae PittGG outer membrane lipoprotein LolB YP_001293161.1 1862229 R 374931 CDS YP_001293162.1 148828409 5227829 complement(1862921..1864171) 1 NC_009567.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 1864171 cca 5227829 cca Haemophilus influenzae PittGG multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase YP_001293162.1 1862921 R 374931 CDS YP_001293163.1 148828410 5227830 complement(1864178..1864789) 1 NC_009567.1 COG3103 SH3 domain protein; hypothetical protein 1864789 5227830 CGSHiGG_10095 Haemophilus influenzae PittGG hypothetical protein YP_001293163.1 1864178 R 374931 CDS YP_001293164.1 148828411 5227831 complement(1864855..1866117) 1 NC_009567.1 COG0306 Phosphate/sulphate permeases; phosphate permease 1866117 5227831 CGSHiGG_10100 Haemophilus influenzae PittGG phosphate permease YP_001293164.1 1864855 R 374931 CDS YP_001293165.1 148828412 5227832 complement(1866142..1866822) 1 NC_009567.1 COG1392 Phosphate transport regulator (distant homolog of PhoU); phosphate transport regulator 1866822 5227832 CGSHiGG_10105 Haemophilus influenzae PittGG phosphate transport regulator YP_001293165.1 1866142 R 374931 CDS YP_001293166.1 148828413 5227833 1867045..1867485 1 NC_009567.1 COG2259 Predicted membrane protein; hypothetical protein 1867485 5227833 CGSHiGG_10110 Haemophilus influenzae PittGG hypothetical protein YP_001293166.1 1867045 D 374931 CDS YP_001293167.1 148828414 5227834 1867524..1867811 1 NC_009567.1 COG3767 Uncharacterized low-complexity protein; hypothetical protein 1867811 lolB 5227834 lolB Haemophilus influenzae PittGG hypothetical protein YP_001293167.1 1867524 D 374931 CDS YP_001293168.1 148828415 5227835 1867871..1868794 1 NC_009567.1 COG3220 Uncharacterized protein conserved in bacteria; hypothetical protein 1868794 5227835 CGSHiGG_10120 Haemophilus influenzae PittGG hypothetical protein YP_001293168.1 1867871 D 374931 CDS YP_001293169.1 148828416 5227836 1868784..1869500 1 NC_009567.1 COG3219 Uncharacterized protein conserved in bacteria; hypothetical protein 1869500 5227836 CGSHiGG_10125 Haemophilus influenzae PittGG hypothetical protein YP_001293169.1 1868784 D 374931 CDS YP_001293170.1 148828417 5227837 1869824..1870870 1 NC_009567.1 COG3025 Uncharacterized conserved protein; hypothetical protein 1870870 5227837 CGSHiGG_10130 Haemophilus influenzae PittGG hypothetical protein YP_001293170.1 1869824 D 374931 CDS YP_001293171.1 148828418 5227838 1872461..1872940 1 NC_009567.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 1872940 5227838 CGSHiGG_10145 Haemophilus influenzae PittGG leucine-responsive transcriptional regulator YP_001293171.1 1872461 D 374931 CDS YP_001293172.1 148828419 5227839 1875752..1876309 1 NC_009567.1 participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 1876309 lolA 5227839 lolA Haemophilus influenzae PittGG outer-membrane lipoprotein carrier protein YP_001293172.1 1875752 D 374931 CDS YP_001293173.1 148828420 5227840 1876370..1877710 1 NC_009567.1 COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase; recombination factor protein RarA 1877710 lolA 5227840 lolA Haemophilus influenzae PittGG recombination factor protein RarA YP_001293173.1 1876370 D 374931 CDS YP_001293174.1 148828421 5227841 complement(1877792..1879090) 1 NC_009567.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1879090 5227841 CGSHiGG_10170 Haemophilus influenzae PittGG 3-phosphoshikimate 1-carboxyvinyltransferase YP_001293174.1 1877792 R 374931 CDS YP_001293175.1 148828422 5227842 complement(1879090..1879926) 1 NC_009567.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 1879926 purU 5227842 purU Haemophilus influenzae PittGG formyltetrahydrofolate deformylase YP_001293175.1 1879090 R 374931 CDS YP_001293176.1 148828423 5227843 complement(1879996..1880400) 1 NC_009567.1 COG2916 DNA-binding protein H-NS; hypothetical protein 1880400 5227843 CGSHiGG_10180 Haemophilus influenzae PittGG hypothetical protein YP_001293176.1 1879996 R 374931 CDS YP_001293177.1 148828424 5227844 1882431..1882580 1 NC_009567.1 COG1757 Na+/H+ antiporter; formyltetrahydrofolate deformylase 1882580 purU 5227844 purU Haemophilus influenzae PittGG formyltetrahydrofolate deformylase YP_001293177.1 1882431 D 374931 CDS YP_001293178.1 148828425 5227845 1884449..1884844 1 NC_009567.1 COG0440 Acetolactate synthase, small (regulatory) subunit; acetolactate synthase 3 regulatory subunit 1884844 ilvH 5227845 ilvH Haemophilus influenzae PittGG acetolactate synthase 3 regulatory subunit YP_001293178.1 1884449 D 374931 CDS YP_001293179.1 148828426 5227846 complement(1885131..1886864) 1 NC_009567.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1886864 argS 5227846 argS Haemophilus influenzae PittGG arginyl-tRNA synthetase YP_001293179.1 1885131 R 374931 CDS