-- dump date 20140619_104340 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 374930000001 SEQ_END SEQ_END NC_009566.1 1813033 1813033 DR NC_009566.1; contig end 1813033..1813033 Haemophilus influenzae PittEE YP_001289887.1 CDS CGSHiEE_00010 NC_009566.1 1450 4413 D COG1629 Outer membrane receptor proteins, mostly Fe transport; hemoglobin-haptoglobin binding protein B 1450..4413 Haemophilus influenzae PittEE 5226334 YP_001289888.1 CDS CGSHiEE_00035 NC_009566.1 6964 8235 D COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; peptidase E 6964..8235 Haemophilus influenzae PittEE 5225155 YP_001289889.1 CDS cpdB NC_009566.1 8329 10302 D periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein 8329..10302 Haemophilus influenzae PittEE 5225149 YP_001289890.1 CDS cpdB NC_009566.1 10568 11047 R COG0500 SAM-dependent methyltransferases; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein complement(10568..11047) Haemophilus influenzae PittEE 5225200 YP_001289891.1 CDS CGSHiEE_00050 NC_009566.1 11499 13388 D GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 11499..13388 Haemophilus influenzae PittEE 5225201 YP_001289892.1 CDS rpsL NC_009566.1 13570 13944 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 13570..13944 Haemophilus influenzae PittEE 5225202 YP_001289893.1 CDS CGSHiEE_00060 NC_009566.1 14102 14572 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 14102..14572 Haemophilus influenzae PittEE 5225183 YP_001289894.1 CDS CGSHiEE_00065 NC_009566.1 14656 16758 D EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 14656..16758 Haemophilus influenzae PittEE 5225184 YP_001289895.1 CDS CGSHiEE_00070 NC_009566.1 16823 18007 D EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 16823..18007 Haemophilus influenzae PittEE 5225185 YP_001289896.1 CDS CGSHiEE_00075 NC_009566.1 18137 18424 R COG2168 Uncharacterized conserved protein involved in oxidation of intracellular sulfur; elongation factor G complement(18137..18424) Haemophilus influenzae PittEE 5225186 YP_001289897.1 CDS CGSHiEE_00080 NC_009566.1 18433 18792 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC complement(18433..18792) Haemophilus influenzae PittEE 5225187 YP_001289898.1 CDS CGSHiEE_00085 NC_009566.1 18789 19169 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD complement(18789..19169) Haemophilus influenzae PittEE 5224905 YP_001289899.1 CDS CGSHiEE_00090 NC_009566.1 19169 19834 R COG2964 Uncharacterized protein conserved in bacteria; hypothetical protein complement(19169..19834) Haemophilus influenzae PittEE 5224906 YP_001289900.1 CDS CGSHiEE_00095 NC_009566.1 19924 20649 R COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1; hypothetical protein complement(19924..20649) Haemophilus influenzae PittEE 5224907 YP_001289901.1 CDS CGSHiEE_00100 NC_009566.1 20747 20968 D COG2900 Uncharacterized protein conserved in bacteria; hypothetical protein 20747..20968 Haemophilus influenzae PittEE 5224908 YP_001289902.1 CDS CGSHiEE_00105 NC_009566.1 21060 21785 R COG0678 Peroxiredoxin; hypothetical protein complement(21060..21785) Haemophilus influenzae PittEE 5224909 YP_001289903.1 CDS CGSHiEE_00110 NC_009566.1 21909 22814 D Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 21909..22814 Haemophilus influenzae PittEE 5226279 YP_001289904.1 CDS CGSHiEE_00115 NC_009566.1 22814 23431 D negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 22814..23431 Haemophilus influenzae PittEE 5226280 YP_001289905.1 CDS greB NC_009566.1 23501 23977 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB complement(23501..23977) Haemophilus influenzae PittEE 5226281 YP_001289906.1 CDS greB NC_009566.1 24073 26385 D COG2183 Transcriptional accessory protein; transcription elongation factor GreB 24073..26385 Haemophilus influenzae PittEE 5226282 YP_001289907.1 CDS gyrB NC_009566.1 26511 28931 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 26511..28931 Haemophilus influenzae PittEE 5226283 YP_001289908.1 CDS CGSHiEE_00135 NC_009566.1 29078 29752 D catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 29078..29752 Haemophilus influenzae PittEE 5226284 YP_001289909.1 CDS CGSHiEE_00140 NC_009566.1 29798 30472 D catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 29798..30472 Haemophilus influenzae PittEE 5224727 YP_001289910.1 CDS CGSHiEE_00145 NC_009566.1 30563 30916 D transposase 30563..30916 Haemophilus influenzae PittEE 5224728 YP_001289911.1 CDS CGSHiEE_00150 NC_009566.1 31084 31200 D COG2963 Transposase and inactivated derivatives; hypothetical protein 31084..31200 Haemophilus influenzae PittEE 5224729 YP_001289912.1 CDS CGSHiEE_00155 NC_009566.1 31113 31352 D COG2801 Transposase and inactivated derivatives; ribulose-phosphate 3-epimerase 31113..31352 Haemophilus influenzae PittEE 5224730 YP_001289913.1 CDS CGSHiEE_00160 NC_009566.1 31415 32407 R catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA complement(31415..32407) Haemophilus influenzae PittEE 5224731 YP_001289914.1 CDS CGSHiEE_00165 NC_009566.1 32561 33013 D transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 32561..33013 Haemophilus influenzae PittEE 5225114 YP_001289915.1 CDS CGSHiEE_00170 NC_009566.1 33039 33434 R COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog); hypothetical protein complement(33039..33434) Haemophilus influenzae PittEE 5225115 YP_001289916.1 CDS CGSHiEE_00175 NC_009566.1 33666 35654 D COG1297 Predicted membrane protein; hypothetical protein 33666..35654 Haemophilus influenzae PittEE 5225116 YP_001289917.1 CDS CGSHiEE_00180 NC_009566.1 35707 36123 D COG1175 ABC-type sugar transport systems, permease components; hypothetical protein 35707..36123 Haemophilus influenzae PittEE 5225117 YP_001289918.1 CDS CGSHiEE_00185 NC_009566.1 36128 36937 D COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase; DNA-binding transcriptional regulator AsnC 36128..36937 Haemophilus influenzae PittEE 5225118 YP_001289919.1 CDS CGSHiEE_00190 NC_009566.1 37013 38497 D catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 37013..38497 Haemophilus influenzae PittEE 5225119 YP_001289920.1 CDS CGSHiEE_00195 NC_009566.1 38582 39280 D COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase; 6-phosphogluconolactonase 38582..39280 Haemophilus influenzae PittEE 5225209 YP_001289921.1 CDS CGSHiEE_00200 NC_009566.1 39291 39737 D virulence-associated protein D 39291..39737 Haemophilus influenzae PittEE 5225210 YP_001289922.1 CDS CGSHiEE_00205 NC_009566.1 39885 40667 D COG3309 Uncharacterized virulence-associated protein D; glucose-6-phosphate 1-dehydrogenase 39885..40667 Haemophilus influenzae PittEE 5225211 YP_001289923.1 CDS CGSHiEE_00210 NC_009566.1 40687 42141 D catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 40687..42141 Haemophilus influenzae PittEE 5225212 YP_001289924.1 CDS CGSHiEE_00215 NC_009566.1 42267 42890 R COG0362 6-phosphogluconate dehydrogenase; 6-phosphogluconate dehydrogenase complement(42267..42890) Haemophilus influenzae PittEE 5225213 YP_001289925.1 CDS apaH NC_009566.1 42900 43727 R hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase complement(42900..43727) Haemophilus influenzae PittEE 5225228 YP_001289926.1 CDS apaH NC_009566.1 43846 44754 D COG3306 Glycosyltransferase involved in LPS biosynthesis; diadenosine tetraphosphatase 43846..44754 Haemophilus influenzae PittEE 5225229 YP_001289927.1 CDS ksgA NC_009566.1 44793 45656 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(44793..45656) Haemophilus influenzae PittEE 5225230 YP_001289928.1 CDS CGSHiEE_00235 NC_009566.1 45740 46735 R COG0438 Glycosyltransferase; lipooligosaccharide glycosyl transferase G complement(45740..46735) Haemophilus influenzae PittEE 5225231 YP_001289929.1 CDS ksgA NC_009566.1 46823 47659 R COG3306 Glycosyltransferase involved in LPS biosynthesis; dimethyladenosine transferase complement(46823..47659) Haemophilus influenzae PittEE 5225232 YP_001289930.1 CDS infA NC_009566.1 47795 48013 D stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 47795..48013 Haemophilus influenzae PittEE 5225233 YP_001289931.1 CDS CGSHiEE_00250 NC_009566.1 48010 48135 R COG0361 Translation initiation factor 1 (IF-1); hypothetical protein complement(48010..48135) Haemophilus influenzae PittEE 5226182 YP_001289932.1 CDS rpsF NC_009566.1 48212 48589 D binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 48212..48589 Haemophilus influenzae PittEE 5226183 YP_001289933.1 CDS CGSHiEE_00260 NC_009566.1 48576 48902 D binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 48576..48902 Haemophilus influenzae PittEE 5226184 YP_001289934.1 CDS rpsR NC_009566.1 48915 49142 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 48915..49142 Haemophilus influenzae PittEE 5226185 YP_001289935.1 CDS rplI NC_009566.1 49159 49608 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 49159..49608 Haemophilus influenzae PittEE 5226186 YP_001289936.1 CDS groEL NC_009566.1 49782 51428 R 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL complement(49782..51428) Haemophilus influenzae PittEE 5225427 YP_001289937.1 CDS groES NC_009566.1 51451 51741 R 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES complement(51451..51741) Haemophilus influenzae PittEE 5225428 YP_001289938.1 CDS ureA NC_009566.1 51907 52209 D UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 51907..52209 Haemophilus influenzae PittEE 5225429 YP_001289939.1 CDS ureB NC_009566.1 52286 52591 D ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active; urease subunit beta 52286..52591 Haemophilus influenzae PittEE 5225430 YP_001289940.1 CDS ureC NC_009566.1 52603 54321 D ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 52603..54321 Haemophilus influenzae PittEE 5225431 YP_001289941.1 CDS ureE NC_009566.1 54449 55006 D involved in the assembly of the urease metallocenter; possible nickel donor; urease accessory protein UreE 54449..55006 Haemophilus influenzae PittEE 5225432 YP_001289942.1 CDS CGSHiEE_00305 NC_009566.1 54991 55698 D COG0830 Urease accessory protein UreF; urease accessory protein UreF 54991..55698 Haemophilus influenzae PittEE 5225083 YP_001289943.1 CDS CGSHiEE_00310 NC_009566.1 55843 56478 D COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; urease accessory protein 55843..56478 Haemophilus influenzae PittEE 5225084 YP_001289944.1 CDS groES NC_009566.1 56551 57366 D COG0829 Urease accessory protein UreH; co-chaperonin GroES 56551..57366 Haemophilus influenzae PittEE 5225085 YP_001289945.1 CDS aspA NC_009566.1 57522 58940 D catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 57522..58940 Haemophilus influenzae PittEE 5225086 YP_001289946.1 CDS aspA NC_009566.1 59244 61181 R COG0568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32); aspartate ammonia-lyase complement(59244..61181) Haemophilus influenzae PittEE 5225087 YP_001289947.1 CDS dnaG NC_009566.1 61184 62965 R synthesizes RNA primers at the replication forks; DNA primase complement(61184..62965) Haemophilus influenzae PittEE 5225056 YP_001289948.1 CDS rpsU NC_009566.1 63099 63314 R a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 complement(63099..63314) Haemophilus influenzae PittEE 5225057 YP_001289949.1 CDS CGSHiEE_00340 NC_009566.1 63546 64574 D in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 63546..64574 Haemophilus influenzae PittEE 5225058 YP_001289950.1 CDS CGSHiEE_00345 NC_009566.1 64583 65164 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 64583..65164 Haemophilus influenzae PittEE 5225059 YP_001289951.1 CDS CGSHiEE_00350 NC_009566.1 65201 66421 D COG0814 Amino acid permeases; tyrosine-specific transport protein 2 65201..66421 Haemophilus influenzae PittEE 5225060 YP_001289952.1 CDS CGSHiEE_00355 NC_009566.1 66559 66819 R COG1145 Ferredoxin; putative ferredoxin-like protein complement(66559..66819) Haemophilus influenzae PittEE 5225061 YP_001289953.1 CDS CGSHiEE_00360 NC_009566.1 67132 67680 D COG3719 Ribonuclease I; thymidine kinase 67132..67680 Haemophilus influenzae PittEE 5225021 YP_001289954.1 CDS pgk NC_009566.1 67776 68936 D Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 67776..68936 Haemophilus influenzae PittEE 5225022 YP_001289955.1 CDS CGSHiEE_00370 NC_009566.1 69047 70126 D catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 69047..70126 Haemophilus influenzae PittEE 5225023 YP_001289956.1 CDS CGSHiEE_00395 NC_009566.1 72066 73610 D COG1882 Pyruvate-formate lyase; hypothetical protein 72066..73610 Haemophilus influenzae PittEE 5225024 YP_001289957.1 CDS CGSHiEE_00400 NC_009566.1 73619 74407 D COG1180 Pyruvate-formate lyase-activating enzyme; hypothetical protein 73619..74407 Haemophilus influenzae PittEE 5225003 YP_001289958.1 CDS CGSHiEE_00405 NC_009566.1 74506 75759 D COG1972 Nucleoside permease; hypothetical protein 74506..75759 Haemophilus influenzae PittEE 5225004 YP_001289959.1 CDS deoD NC_009566.1 75833 76549 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 75833..76549 Haemophilus influenzae PittEE 5225005 YP_001289960.1 CDS rplK NC_009566.1 76720 77148 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 76720..77148 Haemophilus influenzae PittEE 5225006 YP_001289961.1 CDS rplA NC_009566.1 77153 77842 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 77153..77842 Haemophilus influenzae PittEE 5225007 YP_001289962.1 CDS rpoB NC_009566.1 78222 82253 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 78222..82253 Haemophilus influenzae PittEE 5224920 YP_001289963.1 CDS CGSHiEE_00430 NC_009566.1 82391 86641 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 82391..86641 Haemophilus influenzae PittEE 5224921 YP_001289964.1 CDS CGSHiEE_00435 NC_009566.1 86836 87780 D COG1275 Tellurite resistance protein and related permeases; potassium-tellurite ethidium and proflavin transporter 86836..87780 Haemophilus influenzae PittEE 5224922 YP_001289965.1 CDS CGSHiEE_00440 NC_009566.1 87835 88554 R COG1720 Uncharacterized conserved protein; potassium-tellurite ethidium and proflavin transporter complement(87835..88554) Haemophilus influenzae PittEE 5224923 YP_001289966.1 CDS CGSHiEE_00445 NC_009566.1 88616 89527 D catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 88616..89527 Haemophilus influenzae PittEE 5224924 YP_001289967.1 CDS CGSHiEE_00450 NC_009566.1 89578 90066 D regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 89578..90066 Haemophilus influenzae PittEE 5224925 YP_001289968.1 CDS CGSHiEE_00455 NC_009566.1 90201 90752 R COG2862 Predicted membrane protein; hypothetical protein complement(90201..90752) Haemophilus influenzae PittEE 5224884 YP_001289969.1 CDS CGSHiEE_00460 NC_009566.1 90860 91858 R COG1609 Transcriptional regulators; hypothetical protein complement(90860..91858) Haemophilus influenzae PittEE 5224885 YP_001289970.1 CDS CGSHiEE_00465 NC_009566.1 91885 92805 R catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase complement(91885..92805) Haemophilus influenzae PittEE 5224886 YP_001289971.1 CDS CGSHiEE_00470 NC_009566.1 92903 93781 R periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB complement(92903..93781) Haemophilus influenzae PittEE 5224887 YP_001289972.1 CDS rbsC NC_009566.1 93801 94769 R functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease protein complement(93801..94769) Haemophilus influenzae PittEE 5224888 YP_001289973.1 CDS CGSHiEE_00480 NC_009566.1 94785 96266 R with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP binding protein complement(94785..96266) Haemophilus influenzae PittEE 5224878 YP_001289974.1 CDS CGSHiEE_00485 NC_009566.1 96280 96699 R cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase complement(96280..96699) Haemophilus influenzae PittEE 5224879 YP_001289975.1 CDS CGSHiEE_00490 NC_009566.1 96863 98305 R COG1322 Uncharacterized protein conserved in bacteria; DNA recombination protein RmuC complement(96863..98305) Haemophilus influenzae PittEE 5224880 YP_001289976.1 CDS CGSHiEE_00495 NC_009566.1 98470 99660 R COG0665 Glycine/D-amino acid oxidases (deaminating); oxidoreductase OrdL complement(98470..99660) Haemophilus influenzae PittEE 5224881 YP_001289977.1 CDS CGSHiEE_00500 NC_009566.1 99582 99764 R COG0665 Glycine/D-amino acid oxidases (deaminating); oxidoreductase OrdL complement(99582..99764) Haemophilus influenzae PittEE 5224882 YP_001289978.1 CDS CGSHiEE_00505 NC_009566.1 99904 100956 D COG0687 Spermidine/putrescine-binding periplasmic protein; cytoplasmic sugar-binding protein 99904..100956 Haemophilus influenzae PittEE 5224883 YP_001289979.1 CDS hslU NC_009566.1 101026 102360 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU complement(101026..102360) Haemophilus influenzae PittEE 5224873 YP_001289980.1 CDS CGSHiEE_00515 NC_009566.1 102371 102898 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit complement(102371..102898) Haemophilus influenzae PittEE 5224874 YP_001289981.1 CDS aphA NC_009566.1 103118 103825 D Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 103118..103825 Haemophilus influenzae PittEE 5224875 YP_001289982.1 CDS aphA NC_009566.1 103916 104227 R COG2801 Transposase and inactivated derivatives; acid phosphatase/phosphotransferase complement(103916..104227) Haemophilus influenzae PittEE 5224876 YP_001289983.1 CDS CGSHiEE_00530 NC_009566.1 104744 105247 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(104744..105247) Haemophilus influenzae PittEE 5224877 YP_001289984.1 CDS CGSHiEE_00535 NC_009566.1 105432 105848 R COG1238 Predicted membrane protein; hypothetical protein complement(105432..105848) Haemophilus influenzae PittEE 5225182 YP_001289985.1 CDS CGSHiEE_00540 NC_009566.1 105906 106508 R putative phosphatase/phosphohexomutase complement(105906..106508) Haemophilus influenzae PittEE 5224868 YP_001289986.1 CDS CGSHiEE_00545 NC_009566.1 106624 107001 D COG0637 Predicted phosphatase/phosphohexomutase; hypothetical protein 106624..107001 Haemophilus influenzae PittEE 5224869 YP_001289987.1 CDS gidB NC_009566.1 107141 107752 D glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 107141..107752 Haemophilus influenzae PittEE 5224870 YP_001289988.1 CDS CGSHiEE_00555 NC_009566.1 107871 108245 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I 107871..108245 Haemophilus influenzae PittEE 5224871 YP_001289989.1 CDS CGSHiEE_00560 NC_009566.1 108273 109061 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 108273..109061 Haemophilus influenzae PittEE 5224872 YP_001289990.1 CDS CGSHiEE_00565 NC_009566.1 109117 109371 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 109117..109371 Haemophilus influenzae PittEE 5224862 YP_001289991.1 CDS CGSHiEE_00570 NC_009566.1 109421 109891 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 109421..109891 Haemophilus influenzae PittEE 5224863 YP_001289992.1 CDS CGSHiEE_00575 NC_009566.1 109904 110437 D Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 109904..110437 Haemophilus influenzae PittEE 5224864 YP_001289993.1 CDS CGSHiEE_00580 NC_009566.1 110450 111991 D produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 110450..111991 Haemophilus influenzae PittEE 5224865 YP_001289994.1 CDS CGSHiEE_00585 NC_009566.1 112007 112876 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 112007..112876 Haemophilus influenzae PittEE 5224866 YP_001289995.1 CDS CGSHiEE_00590 NC_009566.1 112893 114266 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 112893..114266 Haemophilus influenzae PittEE 5224851 YP_001289996.1 CDS atpC NC_009566.1 114296 114724 D part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 114296..114724 Haemophilus influenzae PittEE 5224852 YP_001289997.1 CDS CGSHiEE_00600 NC_009566.1 114910 116112 R tyrosine-specific transport protein 1 complement(114910..116112) Haemophilus influenzae PittEE 5224853 YP_001289998.1 CDS CGSHiEE_00605 NC_009566.1 116142 116294 R COG0814 Amino acid permeases; hypothetical protein complement(116142..116294) Haemophilus influenzae PittEE 5224854 YP_001289999.1 CDS CGSHiEE_00620 NC_009566.1 117040 117816 R catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF complement(117040..117816) Haemophilus influenzae PittEE 5224855 YP_001290000.1 CDS CGSHiEE_00625 NC_009566.1 117798 118547 R catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase complement(117798..118547) Haemophilus influenzae PittEE 5224767 YP_001290001.1 CDS hisH NC_009566.1 118583 119182 R with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH complement(118583..119182) Haemophilus influenzae PittEE 5224768 YP_001290002.1 CDS CGSHiEE_00635 NC_009566.1 119248 120336 R catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase complement(119248..120336) Haemophilus influenzae PittEE 5224769 YP_001290003.1 CDS CGSHiEE_00640 NC_009566.1 120448 121506 R catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase complement(120448..121506) Haemophilus influenzae PittEE 5224770 YP_001290004.1 CDS hisD NC_009566.1 121620 122903 R catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase complement(121620..122903) Haemophilus influenzae PittEE 5224771 YP_001290005.1 CDS hisG NC_009566.1 122996 123907 R long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase complement(122996..123907) Haemophilus influenzae PittEE 5224772 YP_001290006.1 CDS CGSHiEE_00655 NC_009566.1 124356 125219 D COG1561 Uncharacterized stress-induced protein; hypothetical protein 124356..125219 Haemophilus influenzae PittEE 5224722 YP_001290007.1 CDS CGSHiEE_00660 NC_009566.1 125229 126071 D COG0354 Predicted aminomethyltransferase related to GcvT; hypothetical protein 125229..126071 Haemophilus influenzae PittEE 5224723 YP_001290008.1 CDS CGSHiEE_00665 NC_009566.1 126115 127347 R catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase complement(126115..127347) Haemophilus influenzae PittEE 5224724 YP_001290009.1 CDS CGSHiEE_00670 NC_009566.1 127377 128036 R Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A complement(127377..128036) Haemophilus influenzae PittEE 5224725 YP_001290010.1 CDS CGSHiEE_00675 NC_009566.1 128170 129099 R COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases; coproporphyrinogen III oxidase complement(128170..129099) Haemophilus influenzae PittEE 5224726 YP_001290011.1 CDS CGSHiEE_00680 NC_009566.1 129440 131851 R COG0466 ATP-dependent Lon protease, bacterial type; ATP-dependent proteinase complement(129440..131851) Haemophilus influenzae PittEE 5225262 YP_001290012.1 CDS CGSHiEE_00685 NC_009566.1 132125 132919 D COG2990 Uncharacterized protein conserved in bacteria; hypothetical protein 132125..132919 Haemophilus influenzae PittEE 5225263 YP_001290013.1 CDS mazG NC_009566.1 132969 133760 R functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase complement(132969..133760) Haemophilus influenzae PittEE 5225264 YP_001290014.1 CDS CGSHiEE_00695 NC_009566.1 133892 134431 D regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase 133892..134431 Haemophilus influenzae PittEE 5225265 YP_001290015.1 CDS CGSHiEE_00700 NC_009566.1 134507 135442 D COG0760 Parvulin-like peptidyl-prolyl isomerase; stationary-phase survival protein SurA 134507..135442 Haemophilus influenzae PittEE 5225266 YP_001290016.1 CDS CGSHiEE_00705 NC_009566.1 135512 136555 D COG1559 Predicted periplasmic solute-binding protein; pyrimidine regulatory protein PyrR 135512..136555 Haemophilus influenzae PittEE 5225267 YP_001290017.1 CDS tmk NC_009566.1 136572 137204 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 136572..137204 Haemophilus influenzae PittEE 5225277 YP_001290018.1 CDS CGSHiEE_00715 NC_009566.1 137201 138184 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 137201..138184 Haemophilus influenzae PittEE 5225278 YP_001290019.1 CDS CGSHiEE_00720 NC_009566.1 138238 139020 D putative deoxyribonuclease 138238..139020 Haemophilus influenzae PittEE 5225279 YP_001290020.1 CDS CGSHiEE_00725 NC_009566.1 139103 139570 D COG0084 Mg-dependent DNase; hypothetical protein 139103..139570 Haemophilus influenzae PittEE 5225280 YP_001290021.1 CDS CGSHiEE_00730 NC_009566.1 139627 140919 D COG1253 Hemolysins and related proteins containing CBS domains; hypothetical protein 139627..140919 Haemophilus influenzae PittEE 5225281 YP_001290022.1 CDS CGSHiEE_00735 NC_009566.1 140991 141182 D hypothetical protein 140991..141182 Haemophilus influenzae PittEE 5225331 YP_001290023.1 CDS CGSHiEE_00740 NC_009566.1 141191 141328 D virulence-associated protein D 141191..141328 Haemophilus influenzae PittEE 5225332 YP_001290024.1 CDS CGSHiEE_00745 NC_009566.1 141509 141952 D COG1191 DNA-directed RNA polymerase specialized sigma subunit; hypothetical protein 141509..141952 Haemophilus influenzae PittEE 5225333 YP_001290025.1 CDS CGSHiEE_00750 NC_009566.1 142024 143523 D phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein 142024..143523 Haemophilus influenzae PittEE 5225334 YP_001290026.1 CDS fruK NC_009566.1 143525 144466 D converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase 143525..144466 Haemophilus influenzae PittEE 5225335 YP_001290027.1 CDS fruK NC_009566.1 144468 146138 D COG3925 N-terminal domain of the phosphotransferase system fructose-specific component IIB; 1-phosphofructokinase 144468..146138 Haemophilus influenzae PittEE 5225336 YP_001290028.1 CDS secG NC_009566.1 146684 147022 R COG1314 Preprotein translocase subunit SecG; preprotein translocase subunit SecG complement(146684..147022) Haemophilus influenzae PittEE 5225663 YP_001290029.1 CDS CGSHiEE_00770 NC_009566.1 147130 149085 R decatenates replicating daughter chromosomes; DNA topoisomerase III complement(147130..149085) Haemophilus influenzae PittEE 5225664 YP_001290030.1 CDS recR NC_009566.1 149101 149703 R involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR complement(149101..149703) Haemophilus influenzae PittEE 5225665 YP_001290031.1 CDS CGSHiEE_00780 NC_009566.1 149761 150090 R COG0718 Uncharacterized protein conserved in bacteria; hypothetical protein complement(149761..150090) Haemophilus influenzae PittEE 5225666 YP_001290032.1 CDS CGSHiEE_00785 NC_009566.1 150243 151088 R COG2961 Protein involved in catabolism of external DNA; hypothetical protein complement(150243..151088) Haemophilus influenzae PittEE 5225667 YP_001290033.1 CDS CGSHiEE_00790 NC_009566.1 151161 153761 R COG5009 Membrane carboxypeptidase/penicillin-binding protein; penicillin-binding protein 1A complement(151161..153761) Haemophilus influenzae PittEE 5224867 YP_001290034.1 CDS CGSHiEE_00795 NC_009566.1 153860 154657 D COG0133 Tryptophan synthase beta chain; competence protein A 153860..154657 Haemophilus influenzae PittEE 5225652 YP_001290035.1 CDS CGSHiEE_00800 NC_009566.1 154658 155164 D COG0419 ATPase involved in DNA repair; competence protein B 154658..155164 Haemophilus influenzae PittEE 5225653 YP_001290036.1 CDS CGSHiEE_00805 NC_009566.1 155161 155682 D competence protein C 155161..155682 Haemophilus influenzae PittEE 5225654 YP_001290037.1 CDS CGSHiEE_00810 NC_009566.1 155679 156092 D COG1196 Chromosome segregation ATPases; competence protein D 155679..156092 Haemophilus influenzae PittEE 5225655 YP_001290038.1 CDS CGSHiEE_00815 NC_009566.1 156102 157439 D COG4796 Type II secretory pathway, component HofQ; competence protein E 156102..157439 Haemophilus influenzae PittEE 5225656 YP_001290039.1 CDS recR NC_009566.1 157452 158138 D COG1040 Predicted amidophosphoribosyltransferases; competence protein F 157452..158138 Haemophilus influenzae PittEE 5225422 YP_001290040.1 CDS CGSHiEE_00825 NC_009566.1 158214 158810 D cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; putative DNA uptake protein 158214..158810 Haemophilus influenzae PittEE 5225423 YP_001290041.1 CDS nudC NC_009566.1 158877 159671 D can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 158877..159671 Haemophilus influenzae PittEE 5225424 YP_001290042.1 CDS CGSHiEE_00835 NC_009566.1 159707 160297 D COG3068 Uncharacterized protein conserved in bacteria; hypothetical protein 159707..160297 Haemophilus influenzae PittEE 5225425 YP_001290043.1 CDS nudC NC_009566.1 160437 160709 D COG0776 Bacterial nucleoid DNA-binding protein; NADH pyrophosphatase 160437..160709 Haemophilus influenzae PittEE 5225426 YP_001290044.1 CDS CGSHiEE_00845 NC_009566.1 160822 162654 D Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 160822..162654 Haemophilus influenzae PittEE 5226253 YP_001290045.1 CDS CGSHiEE_00850 NC_009566.1 162706 163239 R disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B complement(162706..163239) Haemophilus influenzae PittEE 5226254 YP_001290046.1 CDS CGSHiEE_00865 NC_009566.1 164921 165646 D Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 164921..165646 Haemophilus influenzae PittEE 5226255 YP_001290047.1 CDS pssA NC_009566.1 165691 167058 R catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase complement(165691..167058) Haemophilus influenzae PittEE 5226256 YP_001290048.1 CDS CGSHiEE_00875 NC_009566.1 167204 167527 D COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes; rRNA methylase 167204..167527 Haemophilus influenzae PittEE 5226257 YP_001290049.1 CDS CGSHiEE_00880 NC_009566.1 167556 168260 D COG0566 rRNA methylases; rRNA methylase 167556..168260 Haemophilus influenzae PittEE 5225342 YP_001290050.1 CDS pssA NC_009566.1 168292 168990 R COG4123 Predicted O-methyltransferase; phosphatidylserine synthase complement(168292..168990) Haemophilus influenzae PittEE 5225343 YP_001290051.1 CDS CGSHiEE_00890 NC_009566.1 169060 170379 D facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 169060..170379 Haemophilus influenzae PittEE 5225344 YP_001290052.1 CDS CGSHiEE_00895 NC_009566.1 170413 171792 R putative protease complement(170413..171792) Haemophilus influenzae PittEE 5225345 YP_001290053.1 CDS CGSHiEE_00900 NC_009566.1 171848 171949 D COG0826 Collagenase and related proteases; hypothetical protein 171848..171949 Haemophilus influenzae PittEE 5225346 YP_001290054.1 CDS CGSHiEE_00905 NC_009566.1 171961 173268 R COG0477 Permeases of the major facilitator superfamily; ATP-dependent RNA helicase SrmB complement(171961..173268) Haemophilus influenzae PittEE 5225347 YP_001290055.1 CDS thiE NC_009566.1 173252 173932 R Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase complement(173252..173932) Haemophilus influenzae PittEE 5225337 YP_001290056.1 CDS CGSHiEE_00915 NC_009566.1 173943 174752 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(173943..174752) Haemophilus influenzae PittEE 5225338 YP_001290057.1 CDS CGSHiEE_00920 NC_009566.1 174745 175536 R catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase complement(174745..175536) Haemophilus influenzae PittEE 5225339 YP_001290058.1 CDS CGSHiEE_00925 NC_009566.1 175866 176102 R COG2145 Hydroxyethylthiazole kinase, sugar kinase family; outer membrane opacity protein B complement(175866..176102) Haemophilus influenzae PittEE 5225340 YP_001290059.1 CDS CGSHiEE_00930 NC_009566.1 176256 179063 R COG1530 Ribonucleases G and E; ribonuclease E complement(176256..179063) Haemophilus influenzae PittEE 5225341 YP_001290060.1 CDS CGSHiEE_00935 NC_009566.1 179485 180453 D catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 179485..180453 Haemophilus influenzae PittEE 5225312 YP_001290061.1 CDS hfq NC_009566.1 180544 180819 D Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 180544..180819 Haemophilus influenzae PittEE 5225313 YP_001290062.1 CDS CGSHiEE_00945 NC_009566.1 180915 181871 R COG3283 Transcriptional regulator of aromatic amino acids metabolism; transcriptional regulatory protein complement(180915..181871) Haemophilus influenzae PittEE 5225314 YP_001290063.1 CDS CGSHiEE_00950 NC_009566.1 181986 183407 R COG0739 Membrane proteins related to metalloendopeptidases; hypothetical protein complement(181986..183407) Haemophilus influenzae PittEE 5225315 YP_001290064.1 CDS CGSHiEE_00955 NC_009566.1 183585 184391 D COG1121 ABC-type Mn/Zn transport systems, ATPase component; ABC transporter ATP-binding protein 183585..184391 Haemophilus influenzae PittEE 5225316 YP_001290065.1 CDS CGSHiEE_00960 NC_009566.1 184391 185176 D COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; 23S rRNA pseudouridylate synthase C 184391..185176 Haemophilus influenzae PittEE 5225317 YP_001290066.1 CDS CGSHiEE_00965 NC_009566.1 185265 186212 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 185265..186212 Haemophilus influenzae PittEE 5225307 YP_001290067.1 CDS CGSHiEE_00970 NC_009566.1 186285 187151 D catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 186285..187151 Haemophilus influenzae PittEE 5225308 YP_001290068.1 CDS CGSHiEE_00975 NC_009566.1 187151 188443 D COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control; pyridoxine kinase 187151..188443 Haemophilus influenzae PittEE 5225309 YP_001290069.1 CDS CGSHiEE_00980 NC_009566.1 188451 189122 R MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein complement(188451..189122) Haemophilus influenzae PittEE 5225310 YP_001290070.1 CDS CGSHiEE_00985 NC_009566.1 189119 189658 R COG0350 Methylated DNA-protein cysteine methyltransferase; methylated-DNA-protein-cysteine methyltransferase complement(189119..189658) Haemophilus influenzae PittEE 5225311 YP_001290071.1 CDS CGSHiEE_00990 NC_009566.1 189734 191104 R COG2067 Long-chain fatty acid transport protein; long-chain fatty acid transport protein complement(189734..191104) Haemophilus influenzae PittEE 5225222 YP_001290072.1 CDS CGSHiEE_00995 NC_009566.1 191310 191597 D COG3691 Uncharacterized protein conserved in bacteria; hypothetical protein 191310..191597 Haemophilus influenzae PittEE 5225223 YP_001290073.1 CDS CGSHiEE_01000 NC_009566.1 191695 192519 R COG1409 Predicted phosphohydrolases; cyclic 3',5'-adenosine monophosphate phosphodiesterase complement(191695..192519) Haemophilus influenzae PittEE 5225224 YP_001290074.1 CDS CGSHiEE_01005 NC_009566.1 192529 193161 R COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; cyclic 3',5'-adenosine monophosphate phosphodiesterase complement(192529..193161) Haemophilus influenzae PittEE 5225225 YP_001290075.1 CDS xseA NC_009566.1 193360 194688 R bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit complement(193360..194688) Haemophilus influenzae PittEE 5225226 YP_001290076.1 CDS xseA NC_009566.1 194681 195895 R COG2850 Uncharacterized conserved protein; exodeoxyribonuclease VII large subunit complement(194681..195895) Haemophilus influenzae PittEE 5225227 YP_001290077.1 CDS CGSHiEE_01020 NC_009566.1 195898 196206 R COG2914 Uncharacterized protein conserved in bacteria; hypothetical protein complement(195898..196206) Haemophilus influenzae PittEE 5225214 YP_001290078.1 CDS CGSHiEE_01025 NC_009566.1 196483 196974 D COG0193 Peptidyl-tRNA hydrolase; peptidyl-tRNA hydrolase 196483..196974 Haemophilus influenzae PittEE 5225215 YP_001290079.1 CDS CGSHiEE_01030 NC_009566.1 197022 198113 D translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 197022..198113 Haemophilus influenzae PittEE 5225216 YP_001290080.1 CDS CGSHiEE_01045 NC_009566.1 200093 201235 R COG0349 Ribonuclease D; ribonuclease D complement(200093..201235) Haemophilus influenzae PittEE 5225217 YP_001290081.1 CDS CGSHiEE_01050 NC_009566.1 201291 202979 R Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(201291..202979) Haemophilus influenzae PittEE 5225194 YP_001290082.1 CDS CGSHiEE_01055 NC_009566.1 203022 203573 R COG3065 Starvation-inducible outer membrane lipoprotein; outer membrane protein complement(203022..203573) Haemophilus influenzae PittEE 5225195 YP_001290083.1 CDS CGSHiEE_01060 NC_009566.1 203598 204308 R COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone; hypothetical protein complement(203598..204308) Haemophilus influenzae PittEE 5225196 YP_001290084.1 CDS CGSHiEE_01065 NC_009566.1 204321 206243 R COG1199 Rad3-related DNA helicases; ATP-dependent helicase complement(204321..206243) Haemophilus influenzae PittEE 5225197 YP_001290085.1 CDS CGSHiEE_01070 NC_009566.1 206570 206980 D COG0824 Predicted thioesterase; thioesterase 206570..206980 Haemophilus influenzae PittEE 5225198 YP_001290086.1 CDS CGSHiEE_01075 NC_009566.1 206997 207683 D COG0811 Biopolymer transport proteins; long-chain-fatty-acid--CoA ligase 206997..207683 Haemophilus influenzae PittEE 5225199 YP_001290087.1 CDS CGSHiEE_01080 NC_009566.1 207754 208173 D membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 207754..208173 Haemophilus influenzae PittEE 5225109 YP_001290088.1 CDS tolA NC_009566.1 208189 209367 D inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 208189..209367 Haemophilus influenzae PittEE 5225110 YP_001290089.1 CDS tolB NC_009566.1 209409 210692 D forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 209409..210692 Haemophilus influenzae PittEE 5225111 YP_001290090.1 CDS CGSHiEE_01095 NC_009566.1 210716 211177 D COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; outer membrane protein P6 210716..211177 Haemophilus influenzae PittEE 5225112 YP_001290091.1 CDS CGSHiEE_01110 NC_009566.1 212396 212848 D COG1959 Predicted transcriptional regulator; hypothetical protein 212396..212848 Haemophilus influenzae PittEE 5225113 YP_001290092.1 CDS tolB NC_009566.1 212916 214130 D catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 212916..214130 Haemophilus influenzae PittEE 5225031 YP_001290093.1 CDS CGSHiEE_01120 NC_009566.1 214189 214569 D COG0822 NifU homolog involved in Fe-S cluster formation; scaffold protein 214189..214569 Haemophilus influenzae PittEE 5225032 YP_001290094.1 CDS CGSHiEE_01125 NC_009566.1 214627 214950 D COG0316 Uncharacterized conserved protein; hypothetical protein 214627..214950 Haemophilus influenzae PittEE 5224949 YP_001290095.1 CDS hscB NC_009566.1 214991 215488 D J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB 214991..215488 Haemophilus influenzae PittEE 5224950 YP_001290096.1 CDS CGSHiEE_01135 NC_009566.1 215539 216225 D COG1076 DnaJ-domain-containing proteins 1; hypothetical protein 215539..216225 Haemophilus influenzae PittEE 5224951 YP_001290097.1 CDS hscA NC_009566.1 216244 218103 D involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 216244..218103 Haemophilus influenzae PittEE 5224952 YP_001290098.1 CDS CGSHiEE_01145 NC_009566.1 218143 218484 D COG0633 Ferredoxin; ferredoxin, 2Fe-2S 218143..218484 Haemophilus influenzae PittEE 5224953 YP_001290099.1 CDS CGSHiEE_01150 NC_009566.1 218484 218678 D COG2975 Uncharacterized protein conserved in bacteria; hypothetical protein 218484..218678 Haemophilus influenzae PittEE 5224895 YP_001290100.1 CDS hscA NC_009566.1 218729 219343 R COG2976 Uncharacterized protein conserved in bacteria; hypothetical protein complement(218729..219343) Haemophilus influenzae PittEE 5224896 YP_001290101.1 CDS hisS NC_009566.1 219361 220632 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(219361..220632) Haemophilus influenzae PittEE 5224897 YP_001290102.1 CDS CGSHiEE_01165 NC_009566.1 220642 220710 R COG0124 Histidyl-tRNA synthetase; hypothetical protein complement(220642..220710) Haemophilus influenzae PittEE 5224898 YP_001290103.1 CDS CGSHiEE_01170 NC_009566.1 220710 221747 R COG0821 Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase complement(220710..221747) Haemophilus influenzae PittEE 5224899 YP_001290104.1 CDS CGSHiEE_01175 NC_009566.1 221756 222667 R COG1426 Uncharacterized protein conserved in bacteria; hypothetical protein complement(221756..222667) Haemophilus influenzae PittEE 5224752 YP_001290105.1 CDS ispG NC_009566.1 222739 223278 R COG3063 Tfp pilus assembly protein PilF; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase complement(222739..223278) Haemophilus influenzae PittEE 5224753 YP_001290106.1 CDS CGSHiEE_01185 NC_009566.1 223379 224530 R 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N complement(223379..224530) Haemophilus influenzae PittEE 5224754 YP_001290107.1 CDS CGSHiEE_01190 NC_009566.1 224777 225655 D COG1686 D-alanyl-D-alanine carboxypeptidase; hypothetical protein 224777..225655 Haemophilus influenzae PittEE 5224755 YP_001290108.1 CDS CGSHiEE_01195 NC_009566.1 225749 226213 R COG3064 Membrane protein involved in colicin uptake; hypothetical protein complement(225749..226213) Haemophilus influenzae PittEE 5224756 YP_001290109.1 CDS CGSHiEE_01200 NC_009566.1 226520 227401 D COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin; putative periplasmic chelated iron binding protein 226520..227401 Haemophilus influenzae PittEE 5224757 YP_001290110.1 CDS CGSHiEE_01205 NC_009566.1 227401 228321 D COG1121 ABC-type Mn/Zn transport systems, ATPase component; iron (chelated) transporter ATP-binding protein 227401..228321 Haemophilus influenzae PittEE 5224717 YP_001290111.1 CDS CGSHiEE_01210 NC_009566.1 228325 229173 D COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; iron (chelated) ABC transporter permease protein 228325..229173 Haemophilus influenzae PittEE 5224718 YP_001290112.1 CDS CGSHiEE_01215 NC_009566.1 229166 229981 D COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; iron (chelated) ABC transporter permease protein 229166..229981 Haemophilus influenzae PittEE 5224719 YP_001290113.1 CDS CGSHiEE_01220 NC_009566.1 230081 230728 R COG0819 Putative transcription activator; transcriptional activator complement(230081..230728) Haemophilus influenzae PittEE 5224720 YP_001290114.1 CDS CGSHiEE_01225 NC_009566.1 230738 231682 R COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components; thiamine biosynthesis protein complement(230738..231682) Haemophilus influenzae PittEE 5224721 YP_001290115.1 CDS CGSHiEE_01230 NC_009566.1 231704 232441 R COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component; putative ABC-type nitrate/sulfonate/bicarbonate transport system, permease complement(231704..232441) Haemophilus influenzae PittEE 5225527 YP_001290116.1 CDS CGSHiEE_01235 NC_009566.1 232438 233160 R putative ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase complement(232438..233160) Haemophilus influenzae PittEE 5225528 YP_001290117.1 CDS CGSHiEE_01240 NC_009566.1 233559 234443 D COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component; CMP-neu5Ac--lipooligosaccharide alpha 2-3 sialyltransferase 233559..234443 Haemophilus influenzae PittEE 5225529 YP_001290118.1 CDS CGSHiEE_01245 NC_009566.1 234693 235709 D COG1087 UDP-glucose 4-epimerase; UDP-glucose 4-epimerase 234693..235709 Haemophilus influenzae PittEE 5225530 YP_001290119.1 CDS CGSHiEE_01250 NC_009566.1 235890 237128 D COG0477 Permeases of the major facilitator superfamily; hypothetical protein 235890..237128 Haemophilus influenzae PittEE 5225531 YP_001290120.1 CDS adk NC_009566.1 237211 237855 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 237211..237855 Haemophilus influenzae PittEE 5225532 YP_001290121.1 CDS CGSHiEE_01260 NC_009566.1 238015 238617 R COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit; cytochrome C-type protein NapC complement(238015..238617) Haemophilus influenzae PittEE 5225784 YP_001290122.1 CDS adk NC_009566.1 238632 239075 R COG3043 Nitrate reductase cytochrome c-type subunit; adenylate kinase complement(238632..239075) Haemophilus influenzae PittEE 5225785 YP_001290123.1 CDS napH NC_009566.1 239081 239944 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component complement(239081..239944) Haemophilus influenzae PittEE 5225786 YP_001290124.1 CDS napG NC_009566.1 239944 240777 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component complement(239944..240777) Haemophilus influenzae PittEE 5225787 YP_001290125.1 CDS CGSHiEE_01280 NC_009566.1 240838 243321 R periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit complement(240838..243321) Haemophilus influenzae PittEE 5225788 YP_001290126.1 CDS CGSHiEE_01285 NC_009566.1 243358 243639 R hypothetical protein complement(243358..243639) Haemophilus influenzae PittEE 5226114 YP_001290127.1 CDS napG NC_009566.1 243632 244162 R COG1145 Ferredoxin; quinol dehydrogenase periplasmic component complement(243632..244162) Haemophilus influenzae PittEE 5226115 YP_001290128.1 CDS CGSHiEE_01295 NC_009566.1 244368 244712 R COG3171 Uncharacterized protein conserved in bacteria; hypothetical protein complement(244368..244712) Haemophilus influenzae PittEE 5226116 YP_001290129.1 CDS trmB NC_009566.1 244797 245537 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(244797..245537) Haemophilus influenzae PittEE 5226117 YP_001290130.1 CDS CGSHiEE_01305 NC_009566.1 245622 247814 D binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 245622..247814 Haemophilus influenzae PittEE 5226118 YP_001290131.1 CDS CGSHiEE_01310 NC_009566.1 247856 248902 R COG0628 Predicted permease; hypothetical protein complement(247856..248902) Haemophilus influenzae PittEE 5226119 YP_001290132.1 CDS CGSHiEE_01315 NC_009566.1 248902 249240 R COG0347 Nitrogen regulatory protein PII; nitrogen regulatory protein P-II complement(248902..249240) Haemophilus influenzae PittEE 5225402 YP_001290133.1 CDS mogA NC_009566.1 249242 249835 R forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA complement(249242..249835) Haemophilus influenzae PittEE 5225403 YP_001290134.1 CDS CGSHiEE_01325 NC_009566.1 249918 250274 R COG0818 Diacylglycerol kinase; diacylglycerol kinase complement(249918..250274) Haemophilus influenzae PittEE 5225404 YP_001290135.1 CDS CGSHiEE_01330 NC_009566.1 250289 252520 R COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; GTP pyrophosphokinase complement(250289..252520) Haemophilus influenzae PittEE 5225405 YP_001290136.1 CDS CGSHiEE_01335 NC_009566.1 252740 253321 R COG1403 Restriction endonuclease; HNH endonuclease complement(252740..253321) Haemophilus influenzae PittEE 5225406 YP_001290137.1 CDS CGSHiEE_01340 NC_009566.1 253327 253944 R COG0784 FOG: CheY-like receiver; hypothetical protein complement(253327..253944) Haemophilus influenzae PittEE 5225407 YP_001290138.1 CDS CGSHiEE_01345 NC_009566.1 253960 256245 R COG0326 Molecular chaperone, HSP90 family; histidine kinase complement(253960..256245) Haemophilus influenzae PittEE 5225161 YP_001290139.1 CDS recO NC_009566.1 259333 260043 R involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO complement(259333..260043) Haemophilus influenzae PittEE 5225162 YP_001290140.1 CDS CGSHiEE_01375 NC_009566.1 260046 260450 R COG1381 Recombinational DNA repair protein (RecF pathway); opacity associated protein OapB complement(260046..260450) Haemophilus influenzae PittEE 5225163 YP_001290141.1 CDS CGSHiEE_01380 NC_009566.1 260510 261796 R COG0532 Translation initiation factor 2 (IF-2; GTPase); opacity associated protein complement(260510..261796) Haemophilus influenzae PittEE 5225072 YP_001290142.1 CDS recO NC_009566.1 261904 262920 R COG1509 Lysine 2,3-aminomutase; DNA repair protein RecO complement(261904..262920) Haemophilus influenzae PittEE 5225073 YP_001290143.1 CDS CGSHiEE_01390 NC_009566.1 262958 263524 D Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 262958..263524 Haemophilus influenzae PittEE 5225074 YP_001290144.1 CDS CGSHiEE_01395 NC_009566.1 263876 264460 R COG3923 Primosomal replication protein N''; primosomal replication protein N complement(263876..264460) Haemophilus influenzae PittEE 5225075 YP_001290145.1 CDS CGSHiEE_01410 NC_009566.1 266162 266851 R Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T complement(266162..266851) Haemophilus influenzae PittEE 5225076 YP_001290146.1 CDS CGSHiEE_01415 NC_009566.1 266926 267333 R COG0346 Lactoylglutathione lyase and related lyases; lactoylglutathione lyase complement(266926..267333) Haemophilus influenzae PittEE 5225067 YP_001290147.1 CDS CGSHiEE_01420 NC_009566.1 267400 267804 R COG1487 Predicted nucleic acid-binding protein, contains PIN domain; nucleic acid-binding protein complement(267400..267804) Haemophilus influenzae PittEE 5225069 YP_001290148.1 CDS CGSHiEE_01425 NC_009566.1 267801 268037 R COG4456 Virulence-associated protein and related proteins; hypothetical protein complement(267801..268037) Haemophilus influenzae PittEE 5225070 YP_001290149.1 CDS CGSHiEE_01430 NC_009566.1 268130 268855 R COG0500 SAM-dependent methyltransferases; S-adenosyl-L-methionine-dependent methyltransferase complement(268130..268855) Haemophilus influenzae PittEE 5225071 YP_001290150.1 CDS CGSHiEE_01435 NC_009566.1 268908 269426 R COG1755 Uncharacterized protein conserved in bacteria; hypothetical protein complement(268908..269426) Haemophilus influenzae PittEE 5225008 YP_001290151.1 CDS aspS NC_009566.1 269647 271413 D catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 269647..271413 Haemophilus influenzae PittEE 5225009 YP_001290152.1 CDS CGSHiEE_01445 NC_009566.1 271475 272323 D hypothetical protein 271475..272323 Haemophilus influenzae PittEE 5225010 YP_001290154.1 CDS CGSHiEE_01455 NC_009566.1 272906 273289 D COG2932 Predicted transcriptional regulator; transcriptional regulatory protein 272906..273289 Haemophilus influenzae PittEE 5225012 YP_001290155.1 CDS CGSHiEE_01460 NC_009566.1 273414 274121 R COG2801 Transposase and inactivated derivatives; transposase complement(273414..274121) Haemophilus influenzae PittEE 5224856 YP_001290156.1 CDS CGSHiEE_01465 NC_009566.1 274220 274573 R transposase complement(274220..274573) Haemophilus influenzae PittEE 5224857 YP_001290157.1 CDS aspS NC_009566.1 274871 276139 D COG1914 Mn2+ and Fe2+ transporters of the NRAMP family; aspartyl-tRNA synthetase 274871..276139 Haemophilus influenzae PittEE 5224858 YP_001290158.1 CDS ntpA NC_009566.1 276332 276697 D COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; dATP pyrophosphohydrolase 276332..276697 Haemophilus influenzae PittEE 5224859 YP_001290159.1 CDS CGSHiEE_01480 NC_009566.1 276857 277597 D COG0217 Uncharacterized conserved protein; hypothetical protein 276857..277597 Haemophilus influenzae PittEE 5224860 YP_001290160.1 CDS ruvC NC_009566.1 277644 278216 D endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 277644..278216 Haemophilus influenzae PittEE 5224861 YP_001290161.1 CDS ruvA NC_009566.1 278279 278893 D plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 278279..278893 Haemophilus influenzae PittEE 5225282 YP_001290162.1 CDS ruvB NC_009566.1 278901 279908 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 278901..279908 Haemophilus influenzae PittEE 5225283 YP_001290163.1 CDS ruvB NC_009566.1 279960 280247 R COG1196 Chromosome segregation ATPases; hypothetical protein complement(279960..280247) Haemophilus influenzae PittEE 5225284 YP_001290164.1 CDS xerD NC_009566.1 280420 281313 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD complement(280420..281313) Haemophilus influenzae PittEE 5225285 YP_001290165.1 CDS CGSHiEE_01510 NC_009566.1 281344 282510 R putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; putative 3-phenylpropionic acid transporter complement(281344..282510) Haemophilus influenzae PittEE 5225286 YP_001290166.1 CDS CGSHiEE_01515 NC_009566.1 282510 283325 R catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase complement(282510..283325) Haemophilus influenzae PittEE 5225250 YP_001290167.1 CDS rdgC NC_009566.1 283391 284299 D Required for efficient pilin antigenic variation; recombination associated protein 283391..284299 Haemophilus influenzae PittEE 5225251 YP_001290168.1 CDS CGSHiEE_01525 NC_009566.1 284349 284768 R similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein complement(284349..284768) Haemophilus influenzae PittEE 5225252 YP_001290169.1 CDS CGSHiEE_01530 NC_009566.1 284768 285328 R COG1678 Putative transcriptional regulator; hypothetical protein complement(284768..285328) Haemophilus influenzae PittEE 5225253 YP_001290170.1 CDS CGSHiEE_01535 NC_009566.1 285325 286062 R in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE complement(285325..286062) Haemophilus influenzae PittEE 5225254 YP_001290171.1 CDS lnt NC_009566.1 286112 287680 R Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase complement(286112..287680) Haemophilus influenzae PittEE 5225255 YP_001290172.1 CDS lnt NC_009566.1 287664 288563 R COG4535 Putative Mg2+ and Co2+ transporter CorC; apolipoprotein N-acyltransferase complement(287664..288563) Haemophilus influenzae PittEE 5225137 YP_001290173.1 CDS CGSHiEE_01550 NC_009566.1 289186 289746 R N-acetyl-anhydromuranmyl-L-alanine amidase complement(289186..289746) Haemophilus influenzae PittEE 5225138 YP_001290174.1 CDS CGSHiEE_01555 NC_009566.1 289860 290000 D COG3023 Negative regulator of beta-lactamase expression; hypothetical protein 289860..290000 Haemophilus influenzae PittEE 5225139 YP_001290175.1 CDS CGSHiEE_01560 NC_009566.1 290035 290310 D COG4969 Tfp pilus assembly protein, major pilin PilA; type IV pilin subunit protein 290035..290310 Haemophilus influenzae PittEE 5225140 YP_001290176.1 CDS CGSHiEE_01565 NC_009566.1 290307 291704 D COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB; putative type IV pilin secretion protein 290307..291704 Haemophilus influenzae PittEE 5225141 YP_001290177.1 CDS CGSHiEE_01570 NC_009566.1 291701 292918 D COG1459 Type II secretory pathway, component PulF; putative type IV pilin secretion protein 291701..292918 Haemophilus influenzae PittEE 5225142 YP_001290178.1 CDS CGSHiEE_01575 NC_009566.1 292915 293523 D COG1835 Predicted acyltransferases; N-acetyl-anhydromuranmyl-L-alanine amidase 292915..293523 Haemophilus influenzae PittEE 5225094 YP_001290179.1 CDS rho NC_009566.1 293662 294924 R An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho complement(293662..294924) Haemophilus influenzae PittEE 5225095 YP_001290180.1 CDS CGSHiEE_01585 NC_009566.1 295174 295491 D when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ 295174..295491 Haemophilus influenzae PittEE 5225096 YP_001290181.1 CDS CGSHiEE_01590 NC_009566.1 295505 295891 R COG0789 Predicted transcriptional regulators; transcriptional regulator MerR family protein complement(295505..295891) Haemophilus influenzae PittEE 5225097 YP_001290182.1 CDS CGSHiEE_01595 NC_009566.1 295968 296174 D COG2608 Copper chaperone; mercuric ion scavenger protein 295968..296174 Haemophilus influenzae PittEE 5225098 YP_001290183.1 CDS CGSHiEE_01600 NC_009566.1 296260 296466 D COG2608 Copper chaperone; mercuric ion scavenger protein 296260..296466 Haemophilus influenzae PittEE 5225077 YP_001290184.1 CDS CGSHiEE_01605 NC_009566.1 296552 296758 D COG2608 Copper chaperone; mercuric ion scavenger protein 296552..296758 Haemophilus influenzae PittEE 5225078 YP_001290185.1 CDS CGSHiEE_01610 NC_009566.1 296733 298901 D COG2217 Cation transport ATPase; putative cation-transporting ATPase 296733..298901 Haemophilus influenzae PittEE 5225079 YP_001290186.1 CDS CGSHiEE_01615 NC_009566.1 299124 300362 D COG0814 Amino acid permeases; serine transporter 299124..300362 Haemophilus influenzae PittEE 5225080 YP_001290187.1 CDS CGSHiEE_01620 NC_009566.1 300396 301763 D COG1760 L-serine deaminase; L-serine deaminase 300396..301763 Haemophilus influenzae PittEE 5225081 YP_001290188.1 CDS CGSHiEE_01625 NC_009566.1 301889 303145 R COG0814 Amino acid permeases; tryptophan-specific transport protein complement(301889..303145) Haemophilus influenzae PittEE 5225082 YP_001290189.1 CDS CGSHiEE_01630 NC_009566.1 303263 304477 R broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT complement(303263..304477) Haemophilus influenzae PittEE 5224986 YP_001290190.1 CDS CGSHiEE_01635 NC_009566.1 304612 305904 D COG1169 Isochorismate synthase; menaquinone-specific isochorismate synthase 304612..305904 Haemophilus influenzae PittEE 5224987 YP_001290191.1 CDS CGSHiEE_01640 NC_009566.1 305919 307625 D SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 305919..307625 Haemophilus influenzae PittEE 5224988 YP_001290192.1 CDS CGSHiEE_01645 NC_009566.1 307686 308429 D catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase YfbB 307686..308429 Haemophilus influenzae PittEE 5224989 YP_001290193.1 CDS CGSHiEE_01650 NC_009566.1 308485 309801 D COG0477 Permeases of the major facilitator superfamily; acyl-CoA thioester hydrolase YfbB 308485..309801 Haemophilus influenzae PittEE 5224990 YP_001290194.1 CDS CGSHiEE_01655 NC_009566.1 310030 310788 R catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase complement(310030..310788) Haemophilus influenzae PittEE 5224970 YP_001290195.1 CDS CGSHiEE_01660 NC_009566.1 311021 311587 D COG2258 Uncharacterized protein conserved in bacteria; uridine phosphorylase 311021..311587 Haemophilus influenzae PittEE 5224971 YP_001290196.1 CDS CGSHiEE_01665 NC_009566.1 311687 312169 D COG3012 Uncharacterized protein conserved in bacteria; hypothetical protein 311687..312169 Haemophilus influenzae PittEE 5224972 YP_001290197.1 CDS rbn NC_009566.1 312166 312975 D RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 312166..312975 Haemophilus influenzae PittEE 5224973 YP_001290198.1 CDS rbn NC_009566.1 312995 314650 R COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily; ribonuclease BN complement(312995..314650) Haemophilus influenzae PittEE 5224974 YP_001290199.1 CDS gltX NC_009566.1 315400 316842 D Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 315400..316842 Haemophilus influenzae PittEE 5224975 YP_001290200.1 CDS rph NC_009566.1 317143 317859 D RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 317143..317859 Haemophilus influenzae PittEE 5224960 YP_001290201.1 CDS pyrE NC_009566.1 317883 318524 D involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 317883..318524 Haemophilus influenzae PittEE 5224961 YP_001290202.1 CDS djlA NC_009566.1 318603 319469 D functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 318603..319469 Haemophilus influenzae PittEE 5224962 YP_001290203.1 CDS djlA NC_009566.1 319469 320401 D COG0042 tRNA-dihydrouridine synthase; DnaJ-like membrane chaperone protein 319469..320401 Haemophilus influenzae PittEE 5224963 YP_001290204.1 CDS CGSHiEE_01705 NC_009566.1 320441 321286 R binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 complement(320441..321286) Haemophilus influenzae PittEE 5224964 YP_001290205.1 CDS CGSHiEE_01710 NC_009566.1 321424 321735 R COG4390 Uncharacterized protein conserved in bacteria; RNA polymerase factor sigma-32 complement(321424..321735) Haemophilus influenzae PittEE 5224807 YP_001290206.1 CDS murB NC_009566.1 321759 322784 R catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase complement(321759..322784) Haemophilus influenzae PittEE 5224808 YP_001290207.1 CDS CGSHiEE_01720 NC_009566.1 322794 324497 R COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific; nitrate/nitrite sensor protein NarQ complement(322794..324497) Haemophilus influenzae PittEE 5224795 YP_001290208.1 CDS CGSHiEE_01725 NC_009566.1 324539 325138 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY complement(324539..325138) Haemophilus influenzae PittEE 5224796 YP_001290209.1 CDS CGSHiEE_01730 NC_009566.1 325221 325577 D COG1539 Dihydroneopterin aldolase; dihydroneopterin aldolase 325221..325577 Haemophilus influenzae PittEE 5224797 YP_001290210.1 CDS CGSHiEE_01735 NC_009566.1 325673 328411 R COG3210 Large exoproteins involved in heme utilization or adhesion; heme/hemopexin-binding protein A complement(325673..328411) Haemophilus influenzae PittEE 5224798 YP_001290211.1 CDS CGSHiEE_01740 NC_009566.1 328423 330111 R COG2831 Hemolysin activation/secretion protein; heme/hemopexin-binding protein B complement(328423..330111) Haemophilus influenzae PittEE 5224799 YP_001290212.1 CDS CGSHiEE_01745 NC_009566.1 330193 332355 R COG1629 Outer membrane receptor proteins, mostly Fe transport; heme-hemopexin utilization protein C complement(330193..332355) Haemophilus influenzae PittEE 5224779 YP_001290213.1 CDS CGSHiEE_01760 NC_009566.1 333797 334522 D catalyzes the phosphorylation of 3-deoxy-D-manno-octulosonic acid at the 4-OH position; 3-deoxy-D-manno-octulosonic-acid kinase 333797..334522 Haemophilus influenzae PittEE 5224780 YP_001290214.1 CDS CGSHiEE_01765 NC_009566.1 334534 335121 D HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 334534..335121 Haemophilus influenzae PittEE 5224781 YP_001290215.1 CDS CGSHiEE_01770 NC_009566.1 335179 336018 D UDP-galactose--lipooligosaccharide galactosyltransferase 335179..336018 Haemophilus influenzae PittEE 5224782 YP_001290216.1 CDS CGSHiEE_01775 NC_009566.1 336011 336133 D COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases; hypothetical protein 336011..336133 Haemophilus influenzae PittEE 5224783 YP_001290217.1 CDS CGSHiEE_01780 NC_009566.1 336544 336867 R COG1544 Ribosome-associated protein Y (PSrp-1); hypothetical protein complement(336544..336867) Haemophilus influenzae PittEE 5224773 YP_001290218.1 CDS CGSHiEE_01785 NC_009566.1 337040 337672 R COG3317 Uncharacterized lipoprotein; putative deoxyribonucleotide triphosphate pyrophosphatase complement(337040..337672) Haemophilus influenzae PittEE 5224774 YP_001290219.1 CDS CGSHiEE_01790 NC_009566.1 337798 338694 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(337798..338694) Haemophilus influenzae PittEE 5224775 YP_001290220.1 CDS bcp NC_009566.1 338795 339262 D bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 338795..339262 Haemophilus influenzae PittEE 5224776 YP_001290221.1 CDS CGSHiEE_01800 NC_009566.1 339405 339857 D COG0811 Biopolymer transport proteins; transport protein ExbB 339405..339857 Haemophilus influenzae PittEE 5224777 YP_001290222.1 CDS CGSHiEE_01805 NC_009566.1 339861 340304 D COG0848 Biopolymer transport protein; biopolymer transport protein 339861..340304 Haemophilus influenzae PittEE 5224778 YP_001290223.1 CDS bcp NC_009566.1 340314 341105 D COG0810 Periplasmic protein TonB, links inner and outer membranes; TonB 340314..341105 Haemophilus influenzae PittEE 5224742 YP_001290224.1 CDS CGSHiEE_01815 NC_009566.1 341291 341797 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(341291..341797) Haemophilus influenzae PittEE 5224745 YP_001290225.1 CDS uvrA NC_009566.1 349563 350009 D COG3468 Type V secretory pathway, adhesin AidA; hypothetical protein 349563..350009 Haemophilus influenzae PittEE 5225274 YP_001290226.1 CDS queA NC_009566.1 350133 351224 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 350133..351224 Haemophilus influenzae PittEE 5225275 YP_001290227.1 CDS tgt NC_009566.1 351569 352717 D Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 351569..352717 Haemophilus influenzae PittEE 5225276 YP_001290228.1 CDS CGSHiEE_01860 NC_009566.1 352782 353300 D COG0457 FOG: TPR repeat; hypothetical protein 352782..353300 Haemophilus influenzae PittEE 5225099 YP_001290229.1 CDS tgt NC_009566.1 353297 353518 D COG0425 Predicted redox protein, regulator of disulfide bond formation; queuine tRNA-ribosyltransferase 353297..353518 Haemophilus influenzae PittEE 5225100 YP_001290230.1 CDS yajC NC_009566.1 353626 353919 D member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 353626..353919 Haemophilus influenzae PittEE 5225101 YP_001290231.1 CDS secF NC_009566.1 355849 356823 D forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 355849..356823 Haemophilus influenzae PittEE 5225102 YP_001290232.1 CDS CGSHiEE_01890 NC_009566.1 356939 357988 R COG0628 Predicted permease; hypothetical protein complement(356939..357988) Haemophilus influenzae PittEE 5225103 YP_001290233.1 CDS CGSHiEE_01895 NC_009566.1 358066 358416 D COG1393 Arsenate reductase and related proteins, glutaredoxin family; putative arsenate reductase 358066..358416 Haemophilus influenzae PittEE 5225051 YP_001290234.1 CDS CGSHiEE_01900 NC_009566.1 358484 358729 D hypothetical protein 358484..358729 Haemophilus influenzae PittEE 5225052 YP_001290235.1 CDS CGSHiEE_01905 NC_009566.1 358749 359045 D hypothetical protein 358749..359045 Haemophilus influenzae PittEE 5225053 YP_001290236.1 CDS CGSHiEE_01910 NC_009566.1 359178 359330 R COG3036 Uncharacterized protein conserved in bacteria; hypothetical protein complement(359178..359330) Haemophilus influenzae PittEE 5225054 YP_001290237.1 CDS CGSHiEE_01915 NC_009566.1 359335 360783 R YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; putative transglycosylase complement(359335..360783) Haemophilus influenzae PittEE 5225055 YP_001290238.1 CDS secF NC_009566.1 360901 362742 R COG0513 Superfamily II DNA and RNA helicases; preprotein translocase subunit SecF complement(360901..362742) Haemophilus influenzae PittEE 5224997 YP_001290239.1 CDS CGSHiEE_01925 NC_009566.1 362921 363754 R lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI complement(362921..363754) Haemophilus influenzae PittEE 5224998 YP_001290240.1 CDS CGSHiEE_01930 NC_009566.1 363935 366064 R COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase); polynucleotide phosphorylase/polyadenylase complement(363935..366064) Haemophilus influenzae PittEE 5224999 YP_001290241.1 CDS CGSHiEE_01935 NC_009566.1 366420 366938 D COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases; hypothetical protein 366420..366938 Haemophilus influenzae PittEE 5225000 YP_001290242.1 CDS CGSHiEE_01940 NC_009566.1 367014 367481 D COG2731 Beta-galactosidase, beta subunit; hypothetical protein 367014..367481 Haemophilus influenzae PittEE 5225001 YP_001290243.1 CDS CGSHiEE_01945 NC_009566.1 367589 368932 R COG1114 Branched-chain amino acid permeases; branched-chain amino acid transport system II carrier protein complement(367589..368932) Haemophilus influenzae PittEE 5225002 YP_001290244.1 CDS CGSHiEE_01950 NC_009566.1 369087 370289 D exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 369087..370289 Haemophilus influenzae PittEE 5224991 YP_001290245.1 CDS CGSHiEE_01955 NC_009566.1 370328 370789 R COG1522 Transcriptional regulators; putative transcriptional regulator complement(370328..370789) Haemophilus influenzae PittEE 5224992 YP_001290246.1 CDS CGSHiEE_01960 NC_009566.1 370909 371799 D COG2962 Predicted permeases; hypothetical protein 370909..371799 Haemophilus influenzae PittEE 5224993 YP_001290247.1 CDS guaA NC_009566.1 371861 373432 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(371861..373432) Haemophilus influenzae PittEE 5224994 YP_001290248.1 CDS CGSHiEE_01970 NC_009566.1 373542 375008 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(373542..375008) Haemophilus influenzae PittEE 5224995 YP_001290249.1 CDS CGSHiEE_01975 NC_009566.1 375138 376043 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 375138..376043 Haemophilus influenzae PittEE 5224996 YP_001290250.1 CDS CGSHiEE_01980 NC_009566.1 382320 382712 D COG3223 Predicted membrane protein; phosphate-starvation-inducible protein PsiE 382320..382712 Haemophilus influenzae PittEE 5224766 YP_001290251.1 CDS CGSHiEE_01985 NC_009566.1 382776 384062 R COG3071 Uncharacterized enzyme of heme biosynthesis; heme biosynthesis protein HemY complement(382776..384062) Haemophilus influenzae PittEE 5224738 YP_001290252.1 CDS CGSHiEE_01990 NC_009566.1 384073 385284 R COG2959 Uncharacterized enzyme of heme biosynthesis; phosphate-starvation-inducible protein PsiE complement(384073..385284) Haemophilus influenzae PittEE 5224741 YP_001290253.1 CDS cyaA NC_009566.1 385590 388121 D catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 385590..388121 Haemophilus influenzae PittEE 5226273 YP_001290254.1 CDS gpsA NC_009566.1 388195 389202 D catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 388195..389202 Haemophilus influenzae PittEE 5226274 YP_001290255.1 CDS cysE NC_009566.1 389219 390022 D catalyzes the O-acetylation of serine; serine acetyltransferase 389219..390022 Haemophilus influenzae PittEE 5226275 YP_001290256.1 CDS CGSHiEE_02010 NC_009566.1 390032 390847 D catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 390032..390847 Haemophilus influenzae PittEE 5226276 YP_001290257.1 CDS CGSHiEE_02015 NC_009566.1 390985 392370 D COG0471 Di- and tricarboxylate transporters; putative di- and tricarboxylate transporter 390985..392370 Haemophilus influenzae PittEE 5226277 YP_001290258.1 CDS CGSHiEE_02020 NC_009566.1 392508 393356 R catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(392508..393356) Haemophilus influenzae PittEE 5226278 YP_001290259.1 CDS CGSHiEE_02035 NC_009566.1 395211 395861 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase complement(395211..395861) Haemophilus influenzae PittEE 5225327 YP_001290260.1 CDS CGSHiEE_02040 NC_009566.1 395881 396315 R COG4154 Fucose dissimilation pathway protein FucU; L-fuculose phosphate aldolase complement(395881..396315) Haemophilus influenzae PittEE 5225328 YP_001290261.1 CDS CGSHiEE_02045 NC_009566.1 396330 397742 R COG1070 Sugar (pentulose and hexulose) kinases; L-fuculokinase complement(396330..397742) Haemophilus influenzae PittEE 5225329 YP_001290262.1 CDS fucI NC_009566.1 397815 399584 R catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase complement(397815..399584) Haemophilus influenzae PittEE 5225330 YP_001290263.1 CDS fucI NC_009566.1 399814 400563 R COG1349 Transcriptional regulators of sugar metabolism; L-fucose isomerase complement(399814..400563) Haemophilus influenzae PittEE 5225244 YP_001290264.1 CDS CGSHiEE_02060 NC_009566.1 400761 403532 D transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA 400761..403532 Haemophilus influenzae PittEE 5225245 YP_001290265.1 CDS CGSHiEE_02065 NC_009566.1 403535 404194 D COG0564 Pseudouridylate synthases, 23S RNA-specific; hypothetical protein 403535..404194 Haemophilus influenzae PittEE 5225203 YP_001290266.1 CDS CGSHiEE_02070 NC_009566.1 404221 404799 D COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid); glp protein 404221..404799 Haemophilus influenzae PittEE 5225204 YP_001290267.1 CDS CGSHiEE_02075 NC_009566.1 404829 405596 D COG1349 Transcriptional regulators of sugar metabolism; glycerol-3-phosphate regulon repressor 404829..405596 Haemophilus influenzae PittEE 5225205 YP_001290268.1 CDS CGSHiEE_02080 NC_009566.1 405898 406719 R COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen; putative D-methionine-binding lipoprotein MetQ complement(405898..406719) Haemophilus influenzae PittEE 5225206 YP_001290269.1 CDS CGSHiEE_02085 NC_009566.1 406758 407447 R COG2011 ABC-type metal ion transport system, permease component; ATP-dependent helicase HepA complement(406758..407447) Haemophilus influenzae PittEE 5225207 YP_001290270.1 CDS metN NC_009566.1 407437 408474 R part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit complement(407437..408474) Haemophilus influenzae PittEE 5225208 YP_001290271.1 CDS CGSHiEE_02095 NC_009566.1 408650 409204 D Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 408650..409204 Haemophilus influenzae PittEE 5225035 YP_001290272.1 CDS CGSHiEE_02100 NC_009566.1 415139 415726 D hypothetical protein 415139..415726 Haemophilus influenzae PittEE 5225038 YP_001290273.1 CDS CGSHiEE_02140 NC_009566.1 422744 423898 R hypothetical protein complement(422744..423898) Haemophilus influenzae PittEE 5225020 YP_001290274.1 CDS CGSHiEE_02145 NC_009566.1 423900 425051 R hypothetical protein complement(423900..425051) Haemophilus influenzae PittEE 5224944 YP_001290275.1 CDS CGSHiEE_02150 NC_009566.1 425170 426714 R hypothetical protein complement(425170..426714) Haemophilus influenzae PittEE 5224945 YP_001290276.1 CDS CGSHiEE_02155 NC_009566.1 426946 428985 R oligopeptidase A complement(426946..428985) Haemophilus influenzae PittEE 5224946 YP_001290277.1 CDS CGSHiEE_02160 NC_009566.1 429110 429472 D hypothetical protein 429110..429472 Haemophilus influenzae PittEE 5224947 YP_001290278.1 CDS CGSHiEE_02165 NC_009566.1 429465 431009 D hypothetical protein 429465..431009 Haemophilus influenzae PittEE 5224948 YP_001290279.1 CDS ribA NC_009566.1 431326 431976 R catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II complement(431326..431976) Haemophilus influenzae PittEE 5224934 YP_001290280.1 CDS CGSHiEE_02175 NC_009566.1 432080 432769 D phosphatidylglycerophosphatase B 432080..432769 Haemophilus influenzae PittEE 5224935 YP_001290281.1 CDS CGSHiEE_02180 NC_009566.1 432788 432895 R hypothetical protein complement(432788..432895) Haemophilus influenzae PittEE 5224936 YP_001290282.1 CDS aroB NC_009566.1 434719 435807 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(434719..435807) Haemophilus influenzae PittEE 5224937 YP_001290283.1 CDS aroK NC_009566.1 435827 436369 R catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase complement(435827..436369) Haemophilus influenzae PittEE 5224929 YP_001290284.1 CDS CGSHiEE_02210 NC_009566.1 436656 438467 R NAD nucleotidase complement(436656..438467) Haemophilus influenzae PittEE 5224930 YP_001290285.1 CDS rpsP NC_009566.1 439557 439805 D binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 439557..439805 Haemophilus influenzae PittEE 5224931 YP_001290286.1 CDS rimM NC_009566.1 439851 440378 D Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 439851..440378 Haemophilus influenzae PittEE 5224932 YP_001290287.1 CDS trmD NC_009566.1 440416 441156 D methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 440416..441156 Haemophilus influenzae PittEE 5224933 YP_001290288.1 CDS rplS NC_009566.1 441193 441543 D this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 441193..441543 Haemophilus influenzae PittEE 5224824 YP_001290289.1 CDS CGSHiEE_02255 NC_009566.1 442751 443608 R Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase complement(442751..443608) Haemophilus influenzae PittEE 5224825 YP_001290290.1 CDS CGSHiEE_02260 NC_009566.1 443755 444522 R COG0730 Predicted permeases; hypothetical protein complement(443755..444522) Haemophilus influenzae PittEE 5224826 YP_001290291.1 CDS mepA NC_009566.1 444540 445400 R D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase complement(444540..445400) Haemophilus influenzae PittEE 5224827 YP_001290292.1 CDS CGSHiEE_02270 NC_009566.1 445572 446645 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(445572..446645) Haemophilus influenzae PittEE 5224828 YP_001290293.1 CDS CGSHiEE_02275 NC_009566.1 446655 449975 R small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA complement(446655..449975) Haemophilus influenzae PittEE 5224809 YP_001290294.1 CDS CGSHiEE_02280 NC_009566.1 450017 451375 R COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; O-succinylbenzoic acid--CoA ligase complement(450017..451375) Haemophilus influenzae PittEE 5224810 YP_001290295.1 CDS CGSHiEE_02295 NC_009566.1 452043 452825 D COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); esterase/lipase 452043..452825 Haemophilus influenzae PittEE 5224811 YP_001290296.1 CDS CGSHiEE_02300 NC_009566.1 452922 453446 D An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA 452922..453446 Haemophilus influenzae PittEE 5224812 YP_001290297.1 CDS CGSHiEE_02305 NC_009566.1 453475 453915 D COG0735 Fe2+/Zn2+ uptake regulation proteins; ferric uptake regulation protein 453475..453915 Haemophilus influenzae PittEE 5224813 YP_001290298.1 CDS CGSHiEE_02310 NC_009566.1 454023 455372 R converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase complement(454023..455372) Haemophilus influenzae PittEE 5224784 YP_001290299.1 CDS CGSHiEE_02315 NC_009566.1 455731 456501 R COG0805 Sec-independent protein secretion pathway component TatC; Sec-independent protein translocase protein TatC complement(455731..456501) Haemophilus influenzae PittEE 5224785 YP_001290300.1 CDS CGSHiEE_02320 NC_009566.1 456511 457071 R mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase complement(456511..457071) Haemophilus influenzae PittEE 5224786 YP_001290301.1 CDS CGSHiEE_02325 NC_009566.1 457075 457302 R COG1826 Sec-independent protein secretion pathway components; Sec-independent protein translocase protein TatA/E complement(457075..457302) Haemophilus influenzae PittEE 5224787 YP_001290302.1 CDS CGSHiEE_02330 NC_009566.1 457519 457926 R COG0789 Predicted transcriptional regulators; putative HTH-type transcriptional regulator complement(457519..457926) Haemophilus influenzae PittEE 5224788 YP_001290303.1 CDS CGSHiEE_02335 NC_009566.1 458048 459184 D COG1062 Zn-dependent alcohol dehydrogenases, class III; alcohol dehydrogenase class III 458048..459184 Haemophilus influenzae PittEE 5224789 YP_001290304.1 CDS CGSHiEE_02340 NC_009566.1 459193 460020 D COG0627 Predicted esterase; esterase 459193..460020 Haemophilus influenzae PittEE 5225287 YP_001290305.1 CDS CGSHiEE_02355 NC_009566.1 466752 468095 D uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit A 466752..468095 Haemophilus influenzae PittEE 5225288 YP_001290306.1 CDS CGSHiEE_02360 NC_009566.1 468098 469333 D uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit B 468098..469333 Haemophilus influenzae PittEE 5225289 YP_001290307.1 CDS CGSHiEE_02365 NC_009566.1 469326 470060 D uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit C 469326..470060 Haemophilus influenzae PittEE 5225290 YP_001290308.1 CDS CGSHiEE_02370 NC_009566.1 470060 470686 D Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit D 470060..470686 Haemophilus influenzae PittEE 5225256 YP_001290309.1 CDS CGSHiEE_02375 NC_009566.1 470690 471286 D Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.; Na(+)-translocating NADH-quinone reductase subunit E 470690..471286 Haemophilus influenzae PittEE 5225257 YP_001290310.1 CDS CGSHiEE_02380 NC_009566.1 471299 472534 D uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit F 471299..472534 Haemophilus influenzae PittEE 5225258 YP_001290311.1 CDS CGSHiEE_02385 NC_009566.1 472678 473718 D COG1477 Membrane-associated lipoprotein involved in thiamine biosynthesis; lipoprotein 472678..473718 Haemophilus influenzae PittEE 5225259 YP_001290312.1 CDS CGSHiEE_02390 NC_009566.1 473721 473981 D COG2991 Uncharacterized protein conserved in bacteria; hypothetical protein 473721..473981 Haemophilus influenzae PittEE 5225260 YP_001290313.1 CDS trmU NC_009566.1 475293 476027 R COG1496 Uncharacterized conserved protein; hypothetical protein complement(475293..476027) Haemophilus influenzae PittEE 5225261 YP_001290314.1 CDS rluD NC_009566.1 476029 477003 R responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D complement(476029..477003) Haemophilus influenzae PittEE 5225246 YP_001290315.1 CDS CGSHiEE_02415 NC_009566.1 477111 477899 D COG4105 DNA uptake lipoprotein; hypothetical protein 477111..477899 Haemophilus influenzae PittEE 5225247 YP_001290316.1 CDS CGSHiEE_02440 NC_009566.1 479357 481669 R COG1882 Pyruvate-formate lyase; formate acetyltransferase complement(479357..481669) Haemophilus influenzae PittEE 5225248 YP_001290317.1 CDS CGSHiEE_02445 NC_009566.1 481707 482561 R COG2116 Formate/nitrite family of transporters; putative formate transporter complement(481707..482561) Haemophilus influenzae PittEE 5225249 YP_001290318.1 CDS CGSHiEE_02450 NC_009566.1 483065 483979 D catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 483065..483979 Haemophilus influenzae PittEE 5225164 YP_001290319.1 CDS CGSHiEE_02455 NC_009566.1 484012 484155 D COG1940 Transcriptional regulator/sugar kinase; hypothetical protein 484012..484155 Haemophilus influenzae PittEE 5225165 YP_001290320.1 CDS CGSHiEE_02460 NC_009566.1 484165 485604 D COG1115 Na+/alanine symporter; putative Na+/alanine symporter 484165..485604 Haemophilus influenzae PittEE 5225166 YP_001290321.1 CDS CGSHiEE_02465 NC_009566.1 486375 486725 R COG0271 Stress-induced morphogen (activity unknown); transcriptional regulator complement(486375..486725) Haemophilus influenzae PittEE 5225167 YP_001290322.1 CDS pflA NC_009566.1 486819 487418 D COG3056 Uncharacterized lipoprotein; pyruvate formate lyase-activating enzyme 1 486819..487418 Haemophilus influenzae PittEE 5225168 YP_001290323.1 CDS CGSHiEE_02475 NC_009566.1 487635 489005 D catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 487635..489005 Haemophilus influenzae PittEE 5225169 YP_001290324.1 CDS psd NC_009566.1 489114 489983 R catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase complement(489114..489983) Haemophilus influenzae PittEE 5225143 YP_001290325.1 CDS CGSHiEE_02485 NC_009566.1 490143 490646 D COG1399 Predicted metal-binding, possibly nucleic acid-binding protein; hypothetical protein 490143..490646 Haemophilus influenzae PittEE 5225144 YP_001290326.1 CDS rpmF NC_009566.1 490689 490859 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 490689..490859 Haemophilus influenzae PittEE 5225145 YP_001290327.1 CDS CGSHiEE_02495 NC_009566.1 490909 491010 D COG0333 Ribosomal protein L32; hypothetical protein 490909..491010 Haemophilus influenzae PittEE 5225146 YP_001290328.1 CDS CGSHiEE_02500 NC_009566.1 491119 492012 D FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III 491119..492012 Haemophilus influenzae PittEE 5225147 YP_001290329.1 CDS CGSHiEE_02505 NC_009566.1 492625 493563 D COG0331 (acyl-carrier-protein) S-malonyltransferase; acyl carrier protein S-malonyltransferase 492625..493563 Haemophilus influenzae PittEE 5225148 YP_001290330.1 CDS fabG NC_009566.1 493580 494308 D catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 493580..494308 Haemophilus influenzae PittEE 5225120 YP_001290331.1 CDS acpP NC_009566.1 494563 494793 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 494563..494793 Haemophilus influenzae PittEE 5225121 YP_001290332.1 CDS CGSHiEE_02520 NC_009566.1 494997 496328 D functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter 494997..496328 Haemophilus influenzae PittEE 5225122 YP_001290333.1 CDS CGSHiEE_02525 NC_009566.1 496388 496987 D COG2091 Phosphopantetheinyl transferase; putative 4'-phosphopantetheinyl transferase 496388..496987 Haemophilus influenzae PittEE 5225123 YP_001290334.1 CDS CGSHiEE_02530 NC_009566.1 497216 498436 D COG0330 Membrane protease subunits, stomatin/prohibitin homologs; FtsH protease regulator HflK 497216..498436 Haemophilus influenzae PittEE 5225124 YP_001290335.1 CDS CGSHiEE_02535 NC_009566.1 498436 499323 D COG0330 Membrane protease subunits, stomatin/prohibitin homologs; hypothetical protein 498436..499323 Haemophilus influenzae PittEE 5225045 YP_001290336.1 CDS CGSHiEE_02540 NC_009566.1 499366 499800 R COG2020 Putative protein-S-isoprenylcysteine methyltransferase; putative protein-S-isoprenylcysteine methyltransferase complement(499366..499800) Haemophilus influenzae PittEE 5225046 YP_001290337.1 CDS CGSHiEE_02545 NC_009566.1 499962 501089 R COG3055 Uncharacterized protein conserved in bacteria; N-acetylneuraminic acid mutarotase complement(499962..501089) Haemophilus influenzae PittEE 5225047 YP_001290338.1 CDS CGSHiEE_02550 NC_009566.1 501265 503115 R COG3090 TRAP-type C4-dicarboxylate transport system, small permease component; hypothetical protein complement(501265..503115) Haemophilus influenzae PittEE 5225048 YP_001290339.1 CDS CGSHiEE_02555 NC_009566.1 503180 504076 R COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component; anaerobic C4-dicarboxylate transporter complement(503180..504076) Haemophilus influenzae PittEE 5225049 YP_001290340.1 CDS CGSHiEE_02560 NC_009566.1 504520 505206 D Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 504520..505206 Haemophilus influenzae PittEE 5225050 YP_001290341.1 CDS CGSHiEE_02565 NC_009566.1 505251 506153 D catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 505251..506153 Haemophilus influenzae PittEE 5225025 YP_001290342.1 CDS CGSHiEE_02570 NC_009566.1 506146 507012 D COG1737 Transcriptional regulators; N-acetylmannosamine kinase 506146..507012 Haemophilus influenzae PittEE 5225026 YP_001290343.1 CDS CGSHiEE_02575 NC_009566.1 507023 507904 D catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 507023..507904 Haemophilus influenzae PittEE 5225027 YP_001290344.1 CDS nagB NC_009566.1 508189 509001 D catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 508189..509001 Haemophilus influenzae PittEE 5225028 YP_001290345.1 CDS nagA NC_009566.1 509138 510283 D catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 509138..510283 Haemophilus influenzae PittEE 5225029 YP_001290346.1 CDS nagA NC_009566.1 510483 511541 R COG3203 Outer membrane protein (porin); N-acetylglucosamine-6-phosphate deacetylase complement(510483..511541) Haemophilus influenzae PittEE 5225030 YP_001290347.1 CDS rnhA NC_009566.1 511973 512326 R COG0328 Ribonuclease HI; ribonuclease H complement(511973..512326) Haemophilus influenzae PittEE 5224976 YP_001290348.1 CDS CGSHiEE_02600 NC_009566.1 512327 513097 D 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 512327..513097 Haemophilus influenzae PittEE 5224977 YP_001290349.1 CDS engA NC_009566.1 513780 515294 D EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 513780..515294 Haemophilus influenzae PittEE 5224978 YP_001290350.1 CDS dcd NC_009566.1 517743 518330 R Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase complement(517743..518330) Haemophilus influenzae PittEE 5224979 YP_001290351.1 CDS CGSHiEE_02635 NC_009566.1 518339 518980 R functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase complement(518339..518980) Haemophilus influenzae PittEE 5224980 YP_001290352.1 CDS CGSHiEE_02645 NC_009566.1 520752 521282 D inorganic pyrophosphatase 520752..521282 Haemophilus influenzae PittEE 5224911 YP_001290354.1 CDS CGSHiEE_02655 NC_009566.1 521846 522184 R COG0558 Phosphatidylglycerophosphate synthase; uridine kinase complement(521846..522184) Haemophilus influenzae PittEE 5224913 YP_001290355.1 CDS CGSHiEE_02660 NC_009566.1 522676 523866 D catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 522676..523866 Haemophilus influenzae PittEE 5224814 YP_001290356.1 CDS CGSHiEE_02665 NC_009566.1 523915 524034 R COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases; hypothetical protein complement(523915..524034) Haemophilus influenzae PittEE 5224815 YP_001290357.1 CDS CGSHiEE_02670 NC_009566.1 524344 525705 D COG0773 UDP-N-acetylmuramate-alanine ligase; UDP-N-acetylmuramoylalanine-D-glutamate ligase-like protein 524344..525705 Haemophilus influenzae PittEE 5224816 YP_001290358.1 CDS CGSHiEE_02675 NC_009566.1 525818 526324 D COG5413 Uncharacterized integral membrane protein; hypothetical protein 525818..526324 Haemophilus influenzae PittEE 5224817 YP_001290359.1 CDS znuA NC_009566.1 526374 527375 R involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic component complement(526374..527375) Haemophilus influenzae PittEE 5224818 YP_001290360.1 CDS znuA NC_009566.1 527553 528338 R COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1; high-affinity zinc transporter periplasmic component complement(527553..528338) Haemophilus influenzae PittEE 5224790 YP_001290361.1 CDS mltA NC_009566.1 528323 529432 R membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A complement(528323..529432) Haemophilus influenzae PittEE 5224791 YP_001290362.1 CDS rlmL NC_009566.1 529827 531962 D catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 529827..531962 Haemophilus influenzae PittEE 5224792 YP_001290363.1 CDS CGSHiEE_02700 NC_009566.1 538668 538772 D COG0116 Predicted N6-adenine-specific DNA methylase; hypothetical protein 538668..538772 Haemophilus influenzae PittEE 5225979 YP_001290364.1 CDS CGSHiEE_02715 NC_009566.1 541806 541961 D COG2801 Transposase and inactivated derivatives; transposase 541806..541961 Haemophilus influenzae PittEE 5225235 YP_001290365.1 CDS CGSHiEE_02720 NC_009566.1 542009 542638 R COG0625 Glutathione S-transferase; methyltransferase complement(542009..542638) Haemophilus influenzae PittEE 5225188 YP_001290366.1 CDS CGSHiEE_02725 NC_009566.1 542973 544262 R catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase complement(542973..544262) Haemophilus influenzae PittEE 5225189 YP_001290367.1 CDS CGSHiEE_02730 NC_009566.1 544535 544660 D COG0172 Seryl-tRNA synthetase; hypothetical protein 544535..544660 Haemophilus influenzae PittEE 5225190 YP_001290368.1 CDS CGSHiEE_02735 NC_009566.1 544614 545357 R COG2966 Uncharacterized conserved protein; hypothetical protein complement(544614..545357) Haemophilus influenzae PittEE 5225191 YP_001290369.1 CDS CGSHiEE_02740 NC_009566.1 545485 546747 R COG4536 Putative Mg2+ and Co2+ transporter CorB; putative Mg2+ and Co2+ transporter complement(545485..546747) Haemophilus influenzae PittEE 5225192 YP_001290370.1 CDS CGSHiEE_02745 NC_009566.1 547028 548407 D COG0541 Signal recognition particle GTPase; Signal recognition particle protein 547028..548407 Haemophilus influenzae PittEE 5225193 YP_001290371.1 CDS CGSHiEE_02750 NC_009566.1 548632 551628 R COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases; putative type I site-specific restriction-modification system, R subunit complement(548632..551628) Haemophilus influenzae PittEE 5225170 YP_001290372.1 CDS CGSHiEE_02755 NC_009566.1 551761 552837 R COG0732 Restriction endonuclease S subunits; putative type I site-specific restriction-modification system, S subunit complement(551761..552837) Haemophilus influenzae PittEE 5225171 YP_001290373.1 CDS CGSHiEE_02760 NC_009566.1 553219 554682 R COG2865 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen; transcription regulator complement(553219..554682) Haemophilus influenzae PittEE 5225172 YP_001290374.1 CDS CGSHiEE_02765 NC_009566.1 554809 557181 R COG0286 Type I restriction-modification system methyltransferase subunit; putative type I restriction-modification system, methyltransferase subunit complement(554809..557181) Haemophilus influenzae PittEE 5225173 YP_001290375.1 CDS CGSHiEE_02770 NC_009566.1 557357 558112 R COG0327 Uncharacterized conserved protein; seryl-tRNA synthetase complement(557357..558112) Haemophilus influenzae PittEE 5225174 YP_001290376.1 CDS CGSHiEE_02775 NC_009566.1 558424 560304 D molecular chaperone; heat shock protein 90 558424..560304 Haemophilus influenzae PittEE 5225175 YP_001290377.1 CDS CGSHiEE_02780 NC_009566.1 560383 560727 D COG1393 Arsenate reductase and related proteins, glutaredoxin family; heat shock protein 90 560383..560727 Haemophilus influenzae PittEE 5224981 YP_001290378.1 CDS CGSHiEE_02785 NC_009566.1 560755 561888 D dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 560755..561888 Haemophilus influenzae PittEE 5224982 YP_001290379.1 CDS CGSHiEE_02790 NC_009566.1 561890 562570 D COG1876 D-alanyl-D-alanine carboxypeptidase; putative D-alanyl-D-alanine carboxypeptidase 561890..562570 Haemophilus influenzae PittEE 5224983 YP_001290380.1 CDS CGSHiEE_02795 NC_009566.1 562605 563675 R COG3842 ABC-type spermidine/putrescine transport systems, ATPase components; iron(III) ABC transporter ATP-binding protein complement(562605..563675) Haemophilus influenzae PittEE 5224984 YP_001290381.1 CDS CGSHiEE_02810 NC_009566.1 565301 566299 R iron-utilization periplasmic protein hFbpA complement(565301..566299) Haemophilus influenzae PittEE 5224985 YP_001290382.1 CDS CGSHiEE_02815 NC_009566.1 566451 566732 R COG1840 ABC-type Fe3+ transport system, periplasmic component; hypothetical protein complement(566451..566732) Haemophilus influenzae PittEE 5224900 YP_001290383.1 CDS CGSHiEE_02820 NC_009566.1 566933 567688 D COG0500 SAM-dependent methyltransferases; hypothetical protein 566933..567688 Haemophilus influenzae PittEE 5224901 YP_001290384.1 CDS CGSHiEE_02825 NC_009566.1 567988 568785 D COG2610 H+/gluconate symporter and related permeases; hypothetical protein 567988..568785 Haemophilus influenzae PittEE 5224902 YP_001290385.1 CDS CGSHiEE_02830 NC_009566.1 568794 569930 D COG1929 Glycerate kinase; hypothetical protein 568794..569930 Haemophilus influenzae PittEE 5224903 YP_001290386.1 CDS CGSHiEE_02835 NC_009566.1 569970 570683 R COG0325 Predicted enzyme with a TIM-barrel fold; hypothetical protein complement(569970..570683) Haemophilus influenzae PittEE 5224904 YP_001290387.1 CDS thrA NC_009566.1 571007 573454 D multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 571007..573454 Haemophilus influenzae PittEE 5224819 YP_001290388.1 CDS CGSHiEE_02845 NC_009566.1 573467 574411 D catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 573467..574411 Haemophilus influenzae PittEE 5224820 YP_001290389.1 CDS CGSHiEE_02850 NC_009566.1 574454 575731 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 574454..575731 Haemophilus influenzae PittEE 5224821 YP_001290390.1 CDS CGSHiEE_02855 NC_009566.1 576581 577690 D catalyzes the formation of cysteine from cystathionine; in B. subtilis also has O-acetylhomoserine thiolyase activity; cystathionine gamma-synthase 576581..577690 Haemophilus influenzae PittEE 5224822 YP_001290391.1 CDS CGSHiEE_02870 NC_009566.1 578818 579141 D COG0526 Thiol-disulfide isomerase and thioredoxins; thioredoxin 578818..579141 Haemophilus influenzae PittEE 5224823 YP_001290392.1 CDS CGSHiEE_02875 NC_009566.1 579191 579442 R hypothetical protein complement(579191..579442) Haemophilus influenzae PittEE 5225417 YP_001290393.1 CDS CGSHiEE_02880 NC_009566.1 579495 579734 R COG0620 Methionine synthase II (cobalamin-independent); hypothetical protein complement(579495..579734) Haemophilus influenzae PittEE 5225418 YP_001290394.1 CDS CGSHiEE_02885 NC_009566.1 579796 580584 R COG0084 Mg-dependent DNase; putative deoxyribonuclease complement(579796..580584) Haemophilus influenzae PittEE 5225419 YP_001290395.1 CDS CGSHiEE_02890 NC_009566.1 580639 581148 R COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; peptidyl-prolyl cis-trans isomerase B complement(580639..581148) Haemophilus influenzae PittEE 5225420 YP_001290396.1 CDS CGSHiEE_02905 NC_009566.1 582706 583572 R COG2833 Uncharacterized protein conserved in bacteria; hypothetical protein complement(582706..583572) Haemophilus influenzae PittEE 5225421 YP_001290397.1 CDS cysS NC_009566.1 583583 584443 R COG1946 Acyl-CoA thioesterase; cysteinyl-tRNA synthetase complement(583583..584443) Haemophilus influenzae PittEE 5225747 YP_001290398.1 CDS CGSHiEE_02915 NC_009566.1 584561 586687 R Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase complement(584561..586687) Haemophilus influenzae PittEE 5225748 YP_001290399.1 CDS CGSHiEE_02920 NC_009566.1 586972 587406 D COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; nucleotidyltransferase 586972..587406 Haemophilus influenzae PittEE 5225749 YP_001290400.1 CDS CGSHiEE_02925 NC_009566.1 587403 587747 D COG1708 Predicted nucleotidyltransferases; hypothetical protein 587403..587747 Haemophilus influenzae PittEE 5225750 YP_001290401.1 CDS CGSHiEE_02930 NC_009566.1 587760 588464 R with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(587760..588464) Haemophilus influenzae PittEE 5225751 YP_001290402.1 CDS ppnK NC_009566.1 588456 589346 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 588456..589346 Haemophilus influenzae PittEE 5225752 YP_001290403.1 CDS CGSHiEE_02940 NC_009566.1 589458 591134 D COG0497 ATPase involved in DNA repair; DNA repair protein 589458..591134 Haemophilus influenzae PittEE 5225870 YP_001290404.1 CDS miaA NC_009566.1 594107 595042 R IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase complement(594107..595042) Haemophilus influenzae PittEE 5225871 YP_001290405.1 CDS mutL NC_009566.1 595050 596939 R This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein complement(595050..596939) Haemophilus influenzae PittEE 5225872 YP_001290406.1 CDS CGSHiEE_02965 NC_009566.1 597109 597996 R COG0860 N-acetylmuramoyl-L-alanine amidase; N-acetylmuramoyl-L-alanine amidase AmiB complement(597109..597996) Haemophilus influenzae PittEE 5225873 YP_001290407.1 CDS CGSHiEE_02970 NC_009566.1 598248 598685 R COG0802 Predicted ATPase or kinase; hypothetical protein complement(598248..598685) Haemophilus influenzae PittEE 5225874 YP_001290408.1 CDS CGSHiEE_02975 NC_009566.1 598800 599282 R COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase complement(598800..599282) Haemophilus influenzae PittEE 5225268 YP_001290409.1 CDS CGSHiEE_02980 NC_009566.1 599291 600835 R COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; poly polymerase complement(599291..600835) Haemophilus influenzae PittEE 5225269 YP_001290410.1 CDS CGSHiEE_02985 NC_009566.1 600898 601335 R DnaK suppressor protein complement(600898..601335) Haemophilus influenzae PittEE 5225270 YP_001290411.1 CDS CGSHiEE_02990 NC_009566.1 601579 601794 R COG1734 DnaK suppressor protein; hypothetical protein complement(601579..601794) Haemophilus influenzae PittEE 5225271 YP_001290412.1 CDS mutL NC_009566.1 601804 603963 D COG0658 Predicted membrane metal-binding protein; DNA mismatch repair protein 601804..603963 Haemophilus influenzae PittEE 5225272 YP_001290413.1 CDS CGSHiEE_03000 NC_009566.1 604004 605767 D involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease protein 604004..605767 Haemophilus influenzae PittEE 5225273 YP_001290414.1 CDS lpxK NC_009566.1 605840 606838 D transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 605840..606838 Haemophilus influenzae PittEE 5225013 YP_001290415.1 CDS CGSHiEE_03010 NC_009566.1 606909 607673 D CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 606909..607673 Haemophilus influenzae PittEE 5225014 YP_001290416.1 CDS CGSHiEE_03015 NC_009566.1 607674 607847 D COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase; hypothetical protein 607674..607847 Haemophilus influenzae PittEE 5225015 YP_001290417.1 CDS uvrC NC_009566.1 607819 609648 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 607819..609648 Haemophilus influenzae PittEE 5225016 YP_001290418.1 CDS uvrC NC_009566.1 609746 610459 D COG0861 Membrane protein TerC, possibly involved in tellurium resistance; excinuclease ABC subunit C 609746..610459 Haemophilus influenzae PittEE 5225017 YP_001290419.1 CDS CGSHiEE_03030 NC_009566.1 610512 611696 R catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase complement(610512..611696) Haemophilus influenzae PittEE 5224841 YP_001290420.1 CDS CGSHiEE_03035 NC_009566.1 611724 612473 R COG2186 Transcriptional regulators; uxu operon regulator complement(611724..612473) Haemophilus influenzae PittEE 5224842 YP_001290421.1 CDS CGSHiEE_03040 NC_009566.1 612633 614675 D COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; zinc-type alcohol dehydrogenase 612633..614675 Haemophilus influenzae PittEE 5224843 YP_001290422.1 CDS CGSHiEE_03045 NC_009566.1 614741 615175 D COG3090 TRAP-type C4-dicarboxylate transport system, small permease component; putative TRAP-type C4-dicarboxylate transport system, small permease 614741..615175 Haemophilus influenzae PittEE 5224844 YP_001290423.1 CDS CGSHiEE_03050 NC_009566.1 615222 616493 D COG1593 TRAP-type C4-dicarboxylate transport system, large permease component; putative TRAP-type C4-dicarboxylate transport system, large permease 615222..616493 Haemophilus influenzae PittEE 5224845 YP_001290424.1 CDS CGSHiEE_03055 NC_009566.1 616513 617457 D COG0524 Sugar kinases, ribokinase family; mannonate dehydratase 616513..617457 Haemophilus influenzae PittEE 5224846 YP_001290425.1 CDS CGSHiEE_03060 NC_009566.1 617469 618314 D Converts D-mannonate to D-mannuronate; D-mannonate oxidoreductase 617469..618314 Haemophilus influenzae PittEE 5225717 YP_001290426.1 CDS CGSHiEE_03065 NC_009566.1 618330 618968 D catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 618330..618968 Haemophilus influenzae PittEE 5225718 YP_001290427.1 CDS CGSHiEE_03070 NC_009566.1 619021 619347 R COG2824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism; hypothetical protein complement(619021..619347) Haemophilus influenzae PittEE 5225719 YP_001290428.1 CDS CGSHiEE_03075 NC_009566.1 619450 620004 D COG3054 Predicted transcriptional regulator; hypothetical protein 619450..620004 Haemophilus influenzae PittEE 5225720 YP_001290429.1 CDS CGSHiEE_03080 NC_009566.1 620331 620993 D COG0670 Integral membrane protein, interacts with FtsH; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 620331..620993 Haemophilus influenzae PittEE 5225721 YP_001290430.1 CDS CGSHiEE_03085 NC_009566.1 621052 622116 D COG3768 Predicted membrane protein; hypothetical protein 621052..622116 Haemophilus influenzae PittEE 5225722 YP_001290431.1 CDS CGSHiEE_03090 NC_009566.1 622116 622790 D COG0564 Pseudouridylate synthases, 23S RNA-specific; hypothetical protein 622116..622790 Haemophilus influenzae PittEE 5225926 YP_001290432.1 CDS CGSHiEE_03095 NC_009566.1 622838 623641 D removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 622838..623641 Haemophilus influenzae PittEE 5225927 YP_001290433.1 CDS CGSHiEE_03100 NC_009566.1 623651 624427 D COG3076 Uncharacterized protein conserved in bacteria; hypothetical protein 623651..624427 Haemophilus influenzae PittEE 5225928 YP_001290434.1 CDS CGSHiEE_03105 NC_009566.1 624478 624966 R rod shape-determining protein MreD complement(624478..624966) Haemophilus influenzae PittEE 5225929 YP_001290435.1 CDS CGSHiEE_03125 NC_009566.1 626103 627134 R functions in MreBCD complex in some organisms; rod shape-determining protein MreB complement(626103..627134) Haemophilus influenzae PittEE 5225930 YP_001290436.1 CDS CGSHiEE_03130 NC_009566.1 627287 629065 R COG4178 ABC-type uncharacterized transport system, permease and ATPase components; exonuclease III complement(627287..629065) Haemophilus influenzae PittEE 5226093 YP_001290437.1 CDS CGSHiEE_03135 NC_009566.1 629271 630926 D COG2985 Predicted permease; hypothetical protein 629271..630926 Haemophilus influenzae PittEE 5226094 YP_001290438.1 CDS CGSHiEE_03140 NC_009566.1 631051 631359 D COG0799 Uncharacterized homolog of plant Iojap protein; hypothetical protein 631051..631359 Haemophilus influenzae PittEE 5226095 YP_001290439.1 CDS CGSHiEE_03145 NC_009566.1 631413 631880 D SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 631413..631880 Haemophilus influenzae PittEE 5226096 YP_001290440.1 CDS CGSHiEE_03150 NC_009566.1 631902 633857 D COG0768 Cell division protein FtsI/penicillin-binding protein 2; penicillin-binding protein 2 631902..633857 Haemophilus influenzae PittEE 5226097 YP_001290441.1 CDS CGSHiEE_03155 NC_009566.1 633847 634962 D COG0772 Bacterial cell division membrane protein; rod shape-determining protein 633847..634962 Haemophilus influenzae PittEE 5225318 YP_001290442.1 CDS CGSHiEE_03160 NC_009566.1 635015 635878 D COG0797 Lipoproteins; lipoprotein 635015..635878 Haemophilus influenzae PittEE 5225319 YP_001290443.1 CDS CGSHiEE_03165 NC_009566.1 635973 637076 D COG1686 D-alanyl-D-alanine carboxypeptidase; hypothetical protein 635973..637076 Haemophilus influenzae PittEE 5225320 YP_001290444.1 CDS CGSHiEE_03170 NC_009566.1 637132 637410 D COG2921 Uncharacterized conserved protein; hypothetical protein 637132..637410 Haemophilus influenzae PittEE 5225321 YP_001290445.1 CDS lipB NC_009566.1 637412 638050 D lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 637412..638050 Haemophilus influenzae PittEE 5225322 YP_001290446.1 CDS CGSHiEE_03180 NC_009566.1 638104 639066 D catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 638104..639066 Haemophilus influenzae PittEE 5225323 YP_001290447.1 CDS CGSHiEE_03185 NC_009566.1 639317 640324 D COG3053 Citrate lyase synthetase; citrate lyase ligase 639317..640324 Haemophilus influenzae PittEE 5225291 YP_001290448.1 CDS CGSHiEE_03190 NC_009566.1 640362 640649 D acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma 640362..640649 Haemophilus influenzae PittEE 5225292 YP_001290449.1 CDS CGSHiEE_03195 NC_009566.1 640646 641521 D COG2301 Citrate lyase beta subunit; citrate lyase beta chain 640646..641521 Haemophilus influenzae PittEE 5225293 YP_001290450.1 CDS CGSHiEE_03200 NC_009566.1 641536 643038 D COG3051 Citrate lyase, alpha subunit; citrate lyase subunit alpha 641536..643038 Haemophilus influenzae PittEE 5225294 YP_001290451.1 CDS CGSHiEE_03205 NC_009566.1 643219 644616 D COG3697 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase); bifunctional Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase/ATP:dephospho-CoA triphosphoribosyl transferase 643219..644616 Haemophilus influenzae PittEE 5225295 YP_001290452.1 CDS CGSHiEE_03210 NC_009566.1 644618 646057 D COG0471 Di- and tricarboxylate transporters; hypothetical protein 644618..646057 Haemophilus influenzae PittEE 5225088 YP_001290453.1 CDS CGSHiEE_03215 NC_009566.1 646440 647864 D catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 646440..647864 Haemophilus influenzae PittEE 5225089 YP_001290454.1 CDS CGSHiEE_03220 NC_009566.1 647934 648593 R Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase complement(647934..648593) Haemophilus influenzae PittEE 5225090 YP_001290455.1 CDS CGSHiEE_03225 NC_009566.1 648851 649234 D stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA 648851..649234 Haemophilus influenzae PittEE 5225091 YP_001290456.1 CDS CGSHiEE_03230 NC_009566.1 649403 651199 D binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 649403..651199 Haemophilus influenzae PittEE 5225092 YP_001290457.1 CDS CGSHiEE_03235 NC_009566.1 651208 652257 D COG0681 Signal peptidase I; GTP-binding protein LepA 651208..652257 Haemophilus influenzae PittEE 5225093 YP_001290458.1 CDS rnc NC_009566.1 652259 652942 D cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 652259..652942 Haemophilus influenzae PittEE 5224965 YP_001290459.1 CDS rsmC NC_009566.1 653912 654904 R 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase complement(653912..654904) Haemophilus influenzae PittEE 5224966 YP_001290460.1 CDS CGSHiEE_03260 NC_009566.1 655010 655414 D with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 655010..655414 Haemophilus influenzae PittEE 5224967 YP_001290461.1 CDS rimI NC_009566.1 655390 655857 D alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 655390..655857 Haemophilus influenzae PittEE 5224968 YP_001290462.1 CDS CGSHiEE_03270 NC_009566.1 655896 656804 R required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE complement(655896..656804) Haemophilus influenzae PittEE 5224969 YP_001290463.1 CDS CGSHiEE_03275 NC_009566.1 656874 657590 R COG2864 Cytochrome b subunit of formate dehydrogenase; formate dehydrogenase subunit gamma complement(656874..657590) Haemophilus influenzae PittEE 5224954 YP_001290464.1 CDS CGSHiEE_03280 NC_009566.1 657583 658521 R COG0437 Fe-S-cluster-containing hydrogenase components 1; formate dehydrogenase iron-sulfur subunit complement(657583..658521) Haemophilus influenzae PittEE 5224955 YP_001290465.1 CDS CGSHiEE_03285 NC_009566.1 658523 660949 R COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; formate dehydrogenase major subunit complement(658523..660949) Haemophilus influenzae PittEE 5224956 YP_001290466.1 CDS CGSHiEE_03290 NC_009566.1 660998 661609 R COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; formate dehydrogenase accessory protein FdhE complement(660998..661609) Haemophilus influenzae PittEE 5224957 YP_001290467.1 CDS CGSHiEE_03295 NC_009566.1 662030 662692 D involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 662030..662692 Haemophilus influenzae PittEE 5224958 YP_001290468.1 CDS CGSHiEE_03300 NC_009566.1 662950 663414 D COG0319 Predicted metal-dependent hydrolase; putative metalloprotease 662950..663414 Haemophilus influenzae PittEE 5224959 YP_001290469.1 CDS CGSHiEE_03305 NC_009566.1 663433 664218 D COG0561 Predicted hydrolases of the HAD superfamily; haloacid dehalogenase-like protein 663433..664218 Haemophilus influenzae PittEE 5225753 YP_001290470.1 CDS CGSHiEE_03310 NC_009566.1 664255 666054 R COG1022 Long-chain acyl-CoA synthetases (AMP-forming); long chain fatty acid CoA ligase complement(664255..666054) Haemophilus influenzae PittEE 5225754 YP_001290471.1 CDS CGSHiEE_03315 NC_009566.1 666249 667268 R COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase complement(666249..667268) Haemophilus influenzae PittEE 5225755 YP_001290472.1 CDS gmk NC_009566.1 667520 668146 D Essential for recycling GMP and indirectly, cGMP; guanylate kinase 667520..668146 Haemophilus influenzae PittEE 5225756 YP_001290473.1 CDS rpoZ NC_009566.1 668209 668475 D promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 668209..668475 Haemophilus influenzae PittEE 5225757 YP_001290474.1 CDS CGSHiEE_03330 NC_009566.1 668548 670662 D COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; guanosine-3',5'-bis 3'-pyrophosphohydrolase 668548..670662 Haemophilus influenzae PittEE 5225758 YP_001290475.1 CDS rpoZ NC_009566.1 670659 672740 D catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 670659..672740 Haemophilus influenzae PittEE 5225156 YP_001290476.1 CDS CGSHiEE_03340 NC_009566.1 672770 673579 D converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 672770..673579 Haemophilus influenzae PittEE 5225157 YP_001290477.1 CDS lldD NC_009566.1 673793 674938 D flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 673793..674938 Haemophilus influenzae PittEE 5225158 YP_001290478.1 CDS CGSHiEE_03350 NC_009566.1 681272 682201 D COG0583 Transcriptional regulator; transcriptional activator 681272..682201 Haemophilus influenzae PittEE 5225509 YP_001290479.1 CDS CGSHiEE_03355 NC_009566.1 682211 682945 D COG1296 Predicted branched-chain amino acid permease (azaleucine resistance); putative branched-chain amino acid permease 682211..682945 Haemophilus influenzae PittEE 5225510 YP_001290480.1 CDS CGSHiEE_03360 NC_009566.1 682942 683271 D putative branched-chain amino acid permease 682942..683271 Haemophilus influenzae PittEE 5225511 YP_001290481.1 CDS lldD NC_009566.1 683374 683607 D COG1687 Predicted branched-chain amino acid permeases (azaleucine resistance); L-lactate dehydrogenase 683374..683607 Haemophilus influenzae PittEE 5225512 YP_001290482.1 CDS prfC NC_009566.1 683683 685266 R stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 complement(683683..685266) Haemophilus influenzae PittEE 5225620 YP_001290483.1 CDS prfC NC_009566.1 685445 686233 D COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH); peptide chain release factor 3 685445..686233 Haemophilus influenzae PittEE 5225621 YP_001290484.1 CDS CGSHiEE_03390 NC_009566.1 688573 689214 D COG2049 Allophanate hydrolase subunit 1; allophanate hydrolase subunit 1 688573..689214 Haemophilus influenzae PittEE 5225624 YP_001290485.1 CDS CGSHiEE_03395 NC_009566.1 689211 690140 D COG1984 Allophanate hydrolase subunit 2; exoribonuclease II 689211..690140 Haemophilus influenzae PittEE 5226160 YP_001290486.1 CDS CGSHiEE_03400 NC_009566.1 690127 690864 D COG1540 Uncharacterized proteins, homologs of lactam utilization protein B; LamB/YcsF family protein 690127..690864 Haemophilus influenzae PittEE 5226161 YP_001290487.1 CDS CGSHiEE_03415 NC_009566.1 692179 693513 R catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase complement(692179..693513) Haemophilus influenzae PittEE 5226162 YP_001290488.1 CDS CGSHiEE_03420 NC_009566.1 693669 694541 R catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase complement(693669..694541) Haemophilus influenzae PittEE 5225236 YP_001290489.1 CDS CGSHiEE_03425 NC_009566.1 694707 697055 R COG0744 Membrane carboxypeptidase (penicillin-binding protein); phosphoribosylaminoimidazole-succinocarboxamide synthase complement(694707..697055) Haemophilus influenzae PittEE 5225237 YP_001290490.1 CDS CGSHiEE_03430 NC_009566.1 697062 697205 R COG3112 Uncharacterized protein conserved in bacteria; hypothetical protein complement(697062..697205) Haemophilus influenzae PittEE 5225238 YP_001290491.1 CDS CGSHiEE_03435 NC_009566.1 697418 697762 R essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA complement(697418..697762) Haemophilus influenzae PittEE 5225239 YP_001290492.1 CDS CGSHiEE_03440 NC_009566.1 697899 698705 D catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 697899..698705 Haemophilus influenzae PittEE 5225240 YP_001290493.1 CDS glnD NC_009566.1 698798 701389 D COG2844 UTP:GlnB (protein PII) uridylyltransferase; PII uridylyl-transferase 698798..701389 Haemophilus influenzae PittEE 5225241 YP_001290494.1 CDS glnD NC_009566.1 701464 702531 D COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase; PII uridylyl-transferase 701464..702531 Haemophilus influenzae PittEE 5224889 YP_001290495.1 CDS CGSHiEE_03455 NC_009566.1 702931 703479 R 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease complement(702931..703479) Haemophilus influenzae PittEE 5224890 YP_001290496.1 CDS CGSHiEE_03460 NC_009566.1 703550 704590 D EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 703550..704590 Haemophilus influenzae PittEE 5224891 YP_001290497.1 CDS CGSHiEE_03465 NC_009566.1 704749 705006 D COG1925 Phosphotransferase system, HPr-related proteins; ribosome-associated GTPase 704749..705006 Haemophilus influenzae PittEE 5224892 YP_001290498.1 CDS CGSHiEE_03470 NC_009566.1 705086 706813 D Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 705086..706813 Haemophilus influenzae PittEE 5224893 YP_001290499.1 CDS CGSHiEE_03475 NC_009566.1 706873 707373 D functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter subunit 706873..707373 Haemophilus influenzae PittEE 5224894 YP_001290500.1 CDS CGSHiEE_03480 NC_009566.1 707556 707768 D COG3257 Uncharacterized protein, possibly involved in glyoxylate utilization; hypothetical protein 707556..707768 Haemophilus influenzae PittEE 5224835 YP_001290501.1 CDS CGSHiEE_03485 NC_009566.1 707883 708248 D COG3111 Uncharacterized conserved protein; hypothetical protein 707883..708248 Haemophilus influenzae PittEE 5224836 YP_001290502.1 CDS CGSHiEE_03490 NC_009566.1 708313 708978 D COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; transcriptional regulatory protein 708313..708978 Haemophilus influenzae PittEE 5224837 YP_001290503.1 CDS CGSHiEE_03495 NC_009566.1 708975 710330 D COG0642 Signal transduction histidine kinase; sensor protein QseC 708975..710330 Haemophilus influenzae PittEE 5224838 YP_001290504.1 CDS CGSHiEE_03500 NC_009566.1 710607 712634 D COG1292 Choline-glycine betaine transporter; glucose-specific PTS system enzyme IIA component 710607..712634 Haemophilus influenzae PittEE 5224839 YP_001290505.1 CDS CGSHiEE_03505 NC_009566.1 712670 714145 R catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase complement(712670..714145) Haemophilus influenzae PittEE 5224840 YP_001290506.1 CDS CGSHiEE_03510 NC_009566.1 714253 715356 D COG0795 Predicted permeases; permease 714253..715356 Haemophilus influenzae PittEE 5225772 YP_001290507.1 CDS CGSHiEE_03515 NC_009566.1 715353 716429 D COG0795 Predicted permeases; leucyl aminopeptidase 715353..716429 Haemophilus influenzae PittEE 5225773 YP_001290508.1 CDS CGSHiEE_03520 NC_009566.1 716623 718893 D catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 716623..718893 Haemophilus influenzae PittEE 5225774 YP_001290509.1 CDS CGSHiEE_03525 NC_009566.1 719116 719859 R COG1434 Uncharacterized conserved protein; hypothetical protein complement(719116..719859) Haemophilus influenzae PittEE 5225775 YP_001290510.1 CDS CGSHiEE_03530 NC_009566.1 719994 721199 D putative lipooligosaccharide flippase 719994..721199 Haemophilus influenzae PittEE 5225776 YP_001290511.1 CDS CGSHiEE_03545 NC_009566.1 722113 723174 D COG0438 Glycosyltransferase; putative UDP-galactose--lipooligosaccharide galactosyltransferase 722113..723174 Haemophilus influenzae PittEE 5225150 YP_001290512.1 CDS CGSHiEE_03550 NC_009566.1 723186 723959 D COG3306 Glycosyltransferase involved in LPS biosynthesis; putative UDP-GlcNAc--lipooligosaccharide N-acetylglucosaminyl glycosyltransferase 723186..723959 Haemophilus influenzae PittEE 5225151 YP_001290513.1 CDS CGSHiEE_03555 NC_009566.1 723971 724855 D COG0463 Glycosyltransferases involved in cell wall biogenesis; putative UDP-galactose--lipooligosaccharide galactosyltransferase 723971..724855 Haemophilus influenzae PittEE 5225152 YP_001290514.1 CDS CGSHiEE_03560 NC_009566.1 724857 725660 D COG0463 Glycosyltransferases involved in cell wall biogenesis; putative UDP-galactose--lipooligosaccharide galactosyltransferase 724857..725660 Haemophilus influenzae PittEE 5225153 YP_001290515.1 CDS CGSHiEE_03565 NC_009566.1 725770 726537 R COG2005 N-terminal domain of molybdenum-binding protein; transcriptional regulator ModE complement(725770..726537) Haemophilus influenzae PittEE 5225154 YP_001290516.1 CDS CGSHiEE_03570 NC_009566.1 726675 727439 D COG0725 ABC-type molybdate transport system, periplasmic component; 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 726675..727439 Haemophilus influenzae PittEE 5224914 YP_001290517.1 CDS modB NC_009566.1 727574 728302 D part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease protein 727574..728302 Haemophilus influenzae PittEE 5224915 YP_001290518.1 CDS modC NC_009566.1 728289 729344 D Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 728289..729344 Haemophilus influenzae PittEE 5224916 YP_001290519.1 CDS CGSHiEE_03585 NC_009566.1 729368 730741 R COG0733 Na+-dependent transporters of the SNF family; Na+-dependent transporter complement(729368..730741) Haemophilus influenzae PittEE 5224917 YP_001290520.1 CDS modC NC_009566.1 730800 731435 R COG0177 Predicted EndoIII-related endonuclease; endonuclease III complement(730800..731435) Haemophilus influenzae PittEE 5224918 YP_001290521.1 CDS CGSHiEE_03595 NC_009566.1 731620 732327 R in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex RsxE subunit complement(731620..732327) Haemophilus influenzae PittEE 5224919 YP_001290522.1 CDS CGSHiEE_03600 NC_009566.1 732329 732952 R part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG complement(732329..732952) Haemophilus influenzae PittEE 5225380 YP_001290523.1 CDS rnfD NC_009566.1 732952 734028 R RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD complement(732952..734028) Haemophilus influenzae PittEE 5225381 YP_001290524.1 CDS CGSHiEE_03610 NC_009566.1 734033 735988 R part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC complement(734033..735988) Haemophilus influenzae PittEE 5225382 YP_001290525.1 CDS CGSHiEE_03615 NC_009566.1 735989 736570 R part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB complement(735989..736570) Haemophilus influenzae PittEE 5225383 YP_001290526.1 CDS CGSHiEE_03620 NC_009566.1 736658 737236 R COG4657 Predicted NADH:ubiquinone oxidoreductase, subunit RnfA; Na(+)-translocating NADH-quinone reductase subunit E complement(736658..737236) Haemophilus influenzae PittEE 5225384 YP_001290527.1 CDS CGSHiEE_03625 NC_009566.1 737520 738581 R SohB; periplasmic protein; member of the peptidase S49 family; putative periplasmic protease complement(737520..738581) Haemophilus influenzae PittEE 5225385 YP_001290528.1 CDS CGSHiEE_03630 NC_009566.1 738779 739444 D COG3110 Uncharacterized protein conserved in bacteria; hypothetical protein 738779..739444 Haemophilus influenzae PittEE 5225894 YP_001290529.1 CDS CGSHiEE_03635 NC_009566.1 739512 741668 D COG1289 Predicted membrane protein; hypothetical protein 739512..741668 Haemophilus influenzae PittEE 5225895 YP_001290530.1 CDS CGSHiEE_03640 NC_009566.1 741872 743698 R COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family; HMW1C, putative glycosyltransferase involved in glycosylation of HMW1A and HMW2A complement(741872..743698) Haemophilus influenzae PittEE 5225896 YP_001290531.1 CDS CGSHiEE_03645 NC_009566.1 743913 745550 R COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component; HMW1B, OMP-85-like protein required for secretion of HMW1A and HMW2A complement(743913..745550) Haemophilus influenzae PittEE 5225897 YP_001290532.1 CDS CGSHiEE_03650 NC_009566.1 745702 750447 R HMW1A, high molecular weight adhesin 1 complement(745702..750447) Haemophilus influenzae PittEE 5225898 YP_001290533.1 CDS CGSHiEE_03655 NC_009566.1 750799 750876 D COG3210 Large exoproteins involved in heme utilization or adhesion; hypothetical protein 750799..750876 Haemophilus influenzae PittEE 5225899 YP_001290534.1 CDS CGSHiEE_03660 NC_009566.1 750967 751290 D COG0675 Transposase and inactivated derivatives; transposase 750967..751290 Haemophilus influenzae PittEE 5225176 YP_001290535.1 CDS CGSHiEE_03665 NC_009566.1 751534 752076 R COG1778 Low specificity phosphatase (HAD superfamily); 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase complement(751534..752076) Haemophilus influenzae PittEE 5225177 YP_001290536.1 CDS CGSHiEE_03670 NC_009566.1 752086 753021 R COG0794 Predicted sugar phosphate isomerase involved in capsule formation; arabinose-5-phosphate isomerase complement(752086..753021) Haemophilus influenzae PittEE 5225178 YP_001290537.1 CDS CGSHiEE_03675 NC_009566.1 753635 754306 R Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein complement(753635..754306) Haemophilus influenzae PittEE 5225179 YP_001290538.1 CDS moaA NC_009566.1 754751 755764 D together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 754751..755764 Haemophilus influenzae PittEE 5225180 YP_001290539.1 CDS moaC NC_009566.1 755855 756337 D MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 755855..756337 Haemophilus influenzae PittEE 5225181 YP_001290540.1 CDS moaD NC_009566.1 756339 756584 D catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 756339..756584 Haemophilus influenzae PittEE 5224938 YP_001290541.1 CDS CGSHiEE_03695 NC_009566.1 756585 757037 D COG0314 Molybdopterin converting factor, large subunit; molybdopterin converting factor subunit 2 756585..757037 Haemophilus influenzae PittEE 5224939 YP_001290542.1 CDS CGSHiEE_03700 NC_009566.1 757092 759737 R COG3008 Paraquat-inducible protein B; paraquat-inducible protein B-like protein complement(757092..759737) Haemophilus influenzae PittEE 5224940 YP_001290543.1 CDS moaD NC_009566.1 759721 760971 R COG2995 Uncharacterized paraquat-inducible protein A; molybdopterin synthase small subunit complement(759721..760971) Haemophilus influenzae PittEE 5224941 YP_001290544.1 CDS CGSHiEE_03710 NC_009566.1 761156 761794 D affects solute and DNA transport through an unknown mechanism; putative solute/DNA competence effector 761156..761794 Haemophilus influenzae PittEE 5224942 YP_001290545.1 CDS CGSHiEE_03715 NC_009566.1 761822 763903 D Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 761822..763903 Haemophilus influenzae PittEE 5224943 YP_001290546.1 CDS CGSHiEE_03720 NC_009566.1 763977 765446 D COG2989 Uncharacterized protein conserved in bacteria; hypothetical protein 763977..765446 Haemophilus influenzae PittEE 5225374 YP_001290547.1 CDS CGSHiEE_03725 NC_009566.1 765462 766022 D COG3108 Uncharacterized protein conserved in bacteria; hypothetical protein 765462..766022 Haemophilus influenzae PittEE 5225375 YP_001290548.1 CDS CGSHiEE_03730 NC_009566.1 766158 766829 D COG0084 Mg-dependent DNase; putative deoxyribonuclease 766158..766829 Haemophilus influenzae PittEE 5225376 YP_001290549.1 CDS CGSHiEE_03735 NC_009566.1 766839 767477 D COG0491 Zn-dependent hydrolases, including glyoxylases; carboxy-terminal protease 766839..767477 Haemophilus influenzae PittEE 5225377 YP_001290550.1 CDS sucA NC_009566.1 767680 770487 D SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 767680..770487 Haemophilus influenzae PittEE 5225378 YP_001290551.1 CDS kgd NC_009566.1 770594 771823 D COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes; alpha-ketoglutarate decarboxylase 770594..771823 Haemophilus influenzae PittEE 5225379 YP_001290552.1 CDS nrdB NC_009566.1 771946 773076 R B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta complement(771946..773076) Haemophilus influenzae PittEE 5225513 YP_001290553.1 CDS CGSHiEE_03755 NC_009566.1 773201 773485 R COG0208 Ribonucleotide reductase, beta subunit; hypothetical protein complement(773201..773485) Haemophilus influenzae PittEE 5225514 YP_001290554.1 CDS CGSHiEE_03760 NC_009566.1 773499 775769 R Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha complement(773499..775769) Haemophilus influenzae PittEE 5225515 YP_001290555.1 CDS CGSHiEE_03765 NC_009566.1 776024 776605 R COG2823 Predicted periplasmic or secreted lipoprotein; hypothetical protein complement(776024..776605) Haemophilus influenzae PittEE 5225516 YP_001290556.1 CDS CGSHiEE_03770 NC_009566.1 776662 777246 R COG0279 Phosphoheptose isomerase; hypothetical protein complement(776662..777246) Haemophilus influenzae PittEE 5225517 YP_001290557.1 CDS CGSHiEE_03775 NC_009566.1 777259 777618 R COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase; hypothetical protein complement(777259..777618) Haemophilus influenzae PittEE 5225518 YP_001290558.1 CDS CGSHiEE_03780 NC_009566.1 777618 779345 R COG3107 Putative lipoprotein; putative lipoprotein complement(777618..779345) Haemophilus influenzae PittEE 5225125 YP_001290559.1 CDS CGSHiEE_03785 NC_009566.1 779417 780268 D COG0313 Predicted methyltransferases; hypothetical protein 779417..780268 Haemophilus influenzae PittEE 5225126 YP_001290560.1 CDS CGSHiEE_03790 NC_009566.1 780370 781818 D COG0312 Predicted Zn-dependent proteases and their inactivated homologs; hypothetical protein 780370..781818 Haemophilus influenzae PittEE 5225127 YP_001290561.1 CDS CGSHiEE_03795 NC_009566.1 781931 782482 D COG0791 Cell wall-associated hydrolases (invasion-associated proteins); lipoprotein NlpC 781931..782482 Haemophilus influenzae PittEE 5225128 YP_001290562.1 CDS CGSHiEE_03800 NC_009566.1 782607 782831 R COG2801 Transposase and inactivated derivatives; transposase complement(782607..782831) Haemophilus influenzae PittEE 5225129 YP_001290563.1 CDS CGSHiEE_03805 NC_009566.1 783032 783310 D COG0513 Superfamily II DNA and RNA helicases; hypothetical protein 783032..783310 Haemophilus influenzae PittEE 5225130 YP_001290564.1 CDS CGSHiEE_03810 NC_009566.1 783559 785253 D component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 783559..785253 Haemophilus influenzae PittEE 5225593 YP_001290565.1 CDS CGSHiEE_03815 NC_009566.1 785802 786380 R with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT complement(785802..786380) Haemophilus influenzae PittEE 5225594 YP_001290566.1 CDS CGSHiEE_03820 NC_009566.1 786381 787256 R with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS complement(786381..787256) Haemophilus influenzae PittEE 5225595 YP_001290567.1 CDS cmk NC_009566.1 787725 788396 D Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 787725..788396 Haemophilus influenzae PittEE 5225596 YP_001290568.1 CDS ihfB NC_009566.1 790272 790556 D This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 790272..790556 Haemophilus influenzae PittEE 5225597 YP_001290569.1 CDS rpsA NC_009566.1 790631 790855 D COG3771 Predicted membrane protein; 30S ribosomal protein S1 790631..790855 Haemophilus influenzae PittEE 5225039 YP_001290570.1 CDS CGSHiEE_03850 NC_009566.1 790923 792113 D COG2956 Predicted N-acetylglucosaminyl transferase; hypothetical protein 790923..792113 Haemophilus influenzae PittEE 5225040 YP_001290571.1 CDS CGSHiEE_03855 NC_009566.1 792137 792829 D type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 792137..792829 Haemophilus influenzae PittEE 5225041 YP_001290572.1 CDS CGSHiEE_03860 NC_009566.1 792836 793156 D involved in start site selection during the initiation of translation; translation initiation factor Sui1 792836..793156 Haemophilus influenzae PittEE 5225042 YP_001290573.1 CDS CGSHiEE_03865 NC_009566.1 793185 793880 R controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor complement(793185..793880) Haemophilus influenzae PittEE 5225043 YP_001290574.1 CDS CGSHiEE_03870 NC_009566.1 793946 795190 R COG2233 Xanthine/uracil permeases; DNA replication initiation factor complement(793946..795190) Haemophilus influenzae PittEE 5225044 YP_001290575.1 CDS upp NC_009566.1 795296 795922 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(795296..795922) Haemophilus influenzae PittEE 5224758 YP_001290576.1 CDS CGSHiEE_03880 NC_009566.1 796046 798112 R catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau complement(796046..798112) Haemophilus influenzae PittEE 5224759 YP_001290577.1 CDS CGSHiEE_03885 NC_009566.1 798124 798666 R catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase complement(798124..798666) Haemophilus influenzae PittEE 5224760 YP_001290578.1 CDS CGSHiEE_03890 NC_009566.1 798672 798779 D COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins; adenine phosphoribosyltransferase 798672..798779 Haemophilus influenzae PittEE 5224761 YP_001290579.1 CDS CGSHiEE_03895 NC_009566.1 798826 800250 R E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase complement(798826..800250) Haemophilus influenzae PittEE 5224762 YP_001290580.1 CDS CGSHiEE_03900 NC_009566.1 800364 801992 R COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes; dihydrolipoamide acetyltransferase complement(800364..801992) Haemophilus influenzae PittEE 5224763 YP_001290581.1 CDS aceE NC_009566.1 802055 804715 R E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 complement(802055..804715) Haemophilus influenzae PittEE 5224732 YP_001290582.1 CDS mgsA NC_009566.1 805015 805473 D catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 805015..805473 Haemophilus influenzae PittEE 5224733 YP_001290583.1 CDS CGSHiEE_03915 NC_009566.1 805630 807072 R hypothetical protein complement(805630..807072) Haemophilus influenzae PittEE 5224734 YP_001290584.1 CDS CGSHiEE_03920 NC_009566.1 807073 807171 R COG5339 Uncharacterized protein conserved in bacteria; hypothetical protein complement(807073..807171) Haemophilus influenzae PittEE 5224735 YP_001290585.1 CDS dnaK NC_009566.1 807325 809232 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 807325..809232 Haemophilus influenzae PittEE 5224736 YP_001290586.1 CDS proA NC_009566.1 810547 811800 R Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase complement(810547..811800) Haemophilus influenzae PittEE 5224737 YP_001290587.1 CDS CGSHiEE_03945 NC_009566.1 811821 812483 R hypothetical protein complement(811821..812483) Haemophilus influenzae PittEE 5225348 YP_001290588.1 CDS proA NC_009566.1 812550 813380 D COG2860 Predicted membrane protein; hypothetical protein 812550..813380 Haemophilus influenzae PittEE 5225349 YP_001290589.1 CDS CGSHiEE_03955 NC_009566.1 813412 814434 R Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system complement(813412..814434) Haemophilus influenzae PittEE 5225350 YP_001290590.1 CDS CGSHiEE_03960 NC_009566.1 814403 814609 R COG0477 Permeases of the major facilitator superfamily; bicyclomycin resistance protein complement(814403..814609) Haemophilus influenzae PittEE 5225351 YP_001290591.1 CDS CGSHiEE_03965 NC_009566.1 814611 815309 R COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; 16S pseudouridylate 516 synthase complement(814611..815309) Haemophilus influenzae PittEE 5225352 YP_001290592.1 CDS CGSHiEE_03970 NC_009566.1 815400 815990 R COG3955 Exopolysaccharide biosynthesis protein; bicyclomycin/multidrug efflux system complement(815400..815990) Haemophilus influenzae PittEE 5225218 YP_001290593.1 CDS CGSHiEE_03975 NC_009566.1 816219 818489 D NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 816219..818489 Haemophilus influenzae PittEE 5225219 YP_001290594.1 CDS CGSHiEE_04000 NC_009566.1 823328 824296 R hypothetical protein complement(823328..824296) Haemophilus influenzae PittEE 5225220 YP_001290595.1 CDS CGSHiEE_04005 NC_009566.1 824299 824919 R hypothetical protein complement(824299..824919) Haemophilus influenzae PittEE 5225221 YP_001290596.1 CDS CGSHiEE_04010 NC_009566.1 825243 825548 D hypothetical protein 825243..825548 Haemophilus influenzae PittEE 5225296 YP_001290597.1 CDS CGSHiEE_04015 NC_009566.1 825559 825882 D hypothetical protein 825559..825882 Haemophilus influenzae PittEE 5225297 YP_001290598.1 CDS CGSHiEE_04020 NC_009566.1 826045 827715 D ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein 826045..827715 Haemophilus influenzae PittEE 5225298 YP_001290599.1 CDS CGSHiEE_04025 NC_009566.1 827777 828118 D hypothetical protein 827777..828118 Haemophilus influenzae PittEE 5225299 YP_001290600.1 CDS CGSHiEE_04030 NC_009566.1 828123 830093 D P-loop ATPase fused to an acetyltransferase 828123..830093 Haemophilus influenzae PittEE 5225300 YP_001290601.1 CDS CGSHiEE_04035 NC_009566.1 830090 830263 D COG1444 Predicted P-loop ATPase fused to an acetyltransferase; hypothetical protein 830090..830263 Haemophilus influenzae PittEE 5225301 YP_001290602.1 CDS CGSHiEE_04040 NC_009566.1 830365 833805 D COG1197 Transcription-repair coupling factor (superfamily II helicase); transcription-repair coupling factor 830365..833805 Haemophilus influenzae PittEE 5224800 YP_001290603.1 CDS CGSHiEE_04045 NC_009566.1 833858 835249 R COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; periplasmic serine protease do/HhoA-like complement(833858..835249) Haemophilus influenzae PittEE 5224801 YP_001290604.1 CDS CGSHiEE_04050 NC_009566.1 835442 836332 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 835442..836332 Haemophilus influenzae PittEE 5224804 YP_001290605.1 CDS CGSHiEE_04065 NC_009566.1 838509 839189 R COG2949 Uncharacterized membrane protein; hypothetical protein complement(838509..839189) Haemophilus influenzae PittEE 5224847 YP_001290606.1 CDS metX NC_009566.1 839347 840423 D Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase 839347..840423 Haemophilus influenzae PittEE 5224848 YP_001290607.1 CDS CGSHiEE_04075 NC_009566.1 840478 843126 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A complement(840478..843126) Haemophilus influenzae PittEE 5224849 YP_001290608.1 CDS CGSHiEE_04080 NC_009566.1 843184 843420 D COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit; hypothetical protein 843184..843420 Haemophilus influenzae PittEE 5224850 YP_001290609.1 CDS CGSHiEE_04095 NC_009566.1 845627 846103 R COG1944 Uncharacterized conserved protein; hypothetical protein complement(845627..846103) Haemophilus influenzae PittEE 5225302 YP_001290610.1 CDS CGSHiEE_04100 NC_009566.1 846339 847145 D COG0500 SAM-dependent methyltransferases; hypothetical protein 846339..847145 Haemophilus influenzae PittEE 5225303 YP_001290611.1 CDS CGSHiEE_04115 NC_009566.1 847956 848816 R with TehA confers resistance to tellurite; tellurite resistance protein TehB complement(847956..848816) Haemophilus influenzae PittEE 5225304 YP_001290612.1 CDS metG NC_009566.1 848929 850977 R methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase complement(848929..850977) Haemophilus influenzae PittEE 5225305 YP_001290613.1 CDS CGSHiEE_04125 NC_009566.1 851126 852238 D COG0489 ATPases involved in chromosome partitioning; putative ATPase 851126..852238 Haemophilus influenzae PittEE 5225306 YP_001290614.1 CDS CGSHiEE_04130 NC_009566.1 852286 852948 R COG0778 Nitroreductase; putative NAD(P)H nitroreductase complement(852286..852948) Haemophilus influenzae PittEE 5226328 YP_001290615.1 CDS CGSHiEE_04135 NC_009566.1 853062 853736 D COG1083 CMP-N-acetylneuraminic acid synthetase; acylneuraminate cytidylyltransferase 853062..853736 Haemophilus influenzae PittEE 5226329 YP_001290616.1 CDS CGSHiEE_04140 NC_009566.1 854214 854330 D transposase 854214..854330 Haemophilus influenzae PittEE 5226330 YP_001290618.1 CDS CGSHiEE_04150 NC_009566.1 855725 856180 D in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 855725..856180 Haemophilus influenzae PittEE 5226332 YP_001290619.1 CDS nusA NC_009566.1 856197 857684 D modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 856197..857684 Haemophilus influenzae PittEE 5226333 YP_001290620.1 CDS infB NC_009566.1 857706 860216 D Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 857706..860216 Haemophilus influenzae PittEE 5226176 YP_001290621.1 CDS CGSHiEE_04165 NC_009566.1 860295 863480 R putative type I restriction enzyme HindVIIP R protein complement(860295..863480) Haemophilus influenzae PittEE 5226177 YP_001290622.1 CDS CGSHiEE_04170 NC_009566.1 863464 864501 R COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases; hypothetical protein complement(863464..864501) Haemophilus influenzae PittEE 5226178 YP_001290623.1 CDS CGSHiEE_04175 NC_009566.1 864491 865894 R COG0732 Restriction endonuclease S subunits; type I restriction/modification specificity protein complement(864491..865894) Haemophilus influenzae PittEE 5226179 YP_001290624.1 CDS infB NC_009566.1 865887 867218 R translation initiation factor IF-2 complement(865887..867218) Haemophilus influenzae PittEE 5226180 YP_001290625.1 CDS rbfA NC_009566.1 867723 868109 D associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 867723..868109 Haemophilus influenzae PittEE 5226013 YP_001290626.1 CDS truB NC_009566.1 868109 869029 D catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 868109..869029 Haemophilus influenzae PittEE 5226014 YP_001290627.1 CDS tyrA NC_009566.1 869118 870242 D catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 869118..870242 Haemophilus influenzae PittEE 5226015 YP_001290628.1 CDS queF NC_009566.1 870275 871114 R related to GTP cyclohydrolase I; catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase complement(870275..871114) Haemophilus influenzae PittEE 5225920 YP_001290629.1 CDS CGSHiEE_04205 NC_009566.1 871241 872026 R COG5595 Zn-ribbon-containing, possibly nucleic-acid-binding protein; hypothetical protein complement(871241..872026) Haemophilus influenzae PittEE 5225921 YP_001290630.1 CDS CGSHiEE_04210 NC_009566.1 872017 872397 R COG2166 SufE protein probably involved in Fe-S center assembly; hypothetical protein complement(872017..872397) Haemophilus influenzae PittEE 5225922 YP_001290631.1 CDS CGSHiEE_04215 NC_009566.1 872394 873593 R COG0520 Selenocysteine lyase; putative selenocysteine lyase complement(872394..873593) Haemophilus influenzae PittEE 5225923 YP_001290632.1 CDS queF NC_009566.1 873595 874056 R COG1525 Micrococcal nuclease (thermonuclease) homologs; 7-cyano-7-deazaguanine reductase complement(873595..874056) Haemophilus influenzae PittEE 5225924 YP_001290633.1 CDS CGSHiEE_04225 NC_009566.1 874192 874623 D COG1380 Putative effector of murein hydrolase LrgA; hypothetical protein 874192..874623 Haemophilus influenzae PittEE 5225925 YP_001290634.1 CDS CGSHiEE_04230 NC_009566.1 874634 875329 D COG1346 Putative effector of murein hydrolase; hypothetical protein 874634..875329 Haemophilus influenzae PittEE 5225826 YP_001290635.1 CDS CGSHiEE_04235 NC_009566.1 875422 876807 D dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein 875422..876807 Haemophilus influenzae PittEE 5225827 YP_001290636.1 CDS CGSHiEE_04240 NC_009566.1 876901 878844 D Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 876901..878844 Haemophilus influenzae PittEE 5225828 YP_001290637.1 CDS CGSHiEE_04245 NC_009566.1 878925 880007 R COG0687 Spermidine/putrescine-binding periplasmic protein; ABC transporter ATPase complement(878925..880007) Haemophilus influenzae PittEE 5225829 YP_001290638.1 CDS potC NC_009566.1 880139 880909 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein complement(880139..880909) Haemophilus influenzae PittEE 5225830 YP_001290639.1 CDS potB NC_009566.1 880909 881769 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein complement(880909..881769) Haemophilus influenzae PittEE 5225831 YP_001290640.1 CDS potA NC_009566.1 881753 882871 R functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase protein complement(881753..882871) Haemophilus influenzae PittEE 5225711 YP_001290641.1 CDS CGSHiEE_04265 NC_009566.1 883168 884406 D catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 883168..884406 Haemophilus influenzae PittEE 5225712 YP_001290642.1 CDS CGSHiEE_04270 NC_009566.1 884978 885460 R COG0783 DNA-binding ferritin-like protein (oxidative damage protectant); peptidase T complement(884978..885460) Haemophilus influenzae PittEE 5225713 YP_001290643.1 CDS CGSHiEE_04275 NC_009566.1 885734 886612 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 885734..886612 Haemophilus influenzae PittEE 5225714 YP_001290644.1 CDS CGSHiEE_04280 NC_009566.1 886656 887621 R COG0500 SAM-dependent methyltransferases; hypothetical protein complement(886656..887621) Haemophilus influenzae PittEE 5225715 YP_001290645.1 CDS CGSHiEE_04285 NC_009566.1 887618 889132 R COG0591 Na+/proline symporter; cytidine deaminase complement(887618..889132) Haemophilus influenzae PittEE 5225716 YP_001290646.1 CDS CGSHiEE_04290 NC_009566.1 889248 890723 D involved in the processing of the 5'end of 16S rRNA; ribonuclease G 889248..890723 Haemophilus influenzae PittEE 5225615 YP_001290647.1 CDS CGSHiEE_04295 NC_009566.1 891268 892938 D catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 891268..892938 Haemophilus influenzae PittEE 5225616 YP_001290648.1 CDS CGSHiEE_04300 NC_009566.1 893016 893468 D COG2983 Uncharacterized conserved protein; hypothetical protein 893016..893468 Haemophilus influenzae PittEE 5225617 YP_001290649.1 CDS CGSHiEE_04305 NC_009566.1 893539 895629 D COG1640 4-alpha-glucanotransferase; hypothetical protein 893539..895629 Haemophilus influenzae PittEE 5225618 YP_001290650.1 CDS CGSHiEE_04320 NC_009566.1 897931 899907 D COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases; glycogen branching enzyme 897931..899907 Haemophilus influenzae PittEE 5225619 YP_001290651.1 CDS glgC NC_009566.1 899930 901231 D catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 899930..901231 Haemophilus influenzae PittEE 5225604 YP_001290652.1 CDS glgA NC_009566.1 901339 902769 D catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 901339..902769 Haemophilus influenzae PittEE 5225605 YP_001290653.1 CDS glgA NC_009566.1 903016 905481 D COG0058 Glucan phosphorylase; glycogen synthase 903016..905481 Haemophilus influenzae PittEE 5225606 YP_001290654.1 CDS pntA NC_009566.1 905742 907280 D forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 905742..907280 Haemophilus influenzae PittEE 5225607 YP_001290655.1 CDS pntB NC_009566.1 908776 909693 R COG0583 Transcriptional regulator; pyridine nucleotide transhydrogenase complement(908776..909693) Haemophilus influenzae PittEE 5225608 YP_001290656.1 CDS CGSHiEE_04360 NC_009566.1 909789 912395 D catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 909789..912395 Haemophilus influenzae PittEE 5225433 YP_001290657.1 CDS CGSHiEE_04365 NC_009566.1 912471 913055 R DNA topoisomerase I complement(912471..913055) Haemophilus influenzae PittEE 5225434 YP_001290658.1 CDS CGSHiEE_04370 NC_009566.1 913137 913340 R COG1182 Acyl carrier protein phosphodiesterase; hypothetical protein complement(913137..913340) Haemophilus influenzae PittEE 5225435 YP_001290659.1 CDS CGSHiEE_04375 NC_009566.1 913340 915271 D catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 913340..915271 Haemophilus influenzae PittEE 5225436 YP_001290660.1 CDS CGSHiEE_04380 NC_009566.1 915394 918177 R COG0612 Predicted Zn-dependent peptidases; putative zinc protease complement(915394..918177) Haemophilus influenzae PittEE 5225437 YP_001290661.1 CDS CGSHiEE_04395 NC_009566.1 920858 921067 R COG3585 Molybdopterin-binding protein; putative molybdenum-pterin binding protein complement(920858..921067) Haemophilus influenzae PittEE 5225438 YP_001290662.1 CDS CGSHiEE_04400 NC_009566.1 921175 921504 R COG2920 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit; putative dissimilatory sulfite reductase, desulfoviridin subunit gamma complement(921175..921504) Haemophilus influenzae PittEE 5225104 YP_001290663.1 CDS CGSHiEE_04405 NC_009566.1 921506 922336 R COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control; threonyl-tRNA synthetase complement(921506..922336) Haemophilus influenzae PittEE 5225105 YP_001290664.1 CDS CGSHiEE_04410 NC_009566.1 922587 923921 D acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 922587..923921 Haemophilus influenzae PittEE 5225106 YP_001290665.1 CDS CGSHiEE_04415 NC_009566.1 924070 924804 D acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 924070..924804 Haemophilus influenzae PittEE 5225107 YP_001290666.1 CDS CGSHiEE_04430 NC_009566.1 929407 930315 D COG3586 Uncharacterized conserved protein; hypothetical protein 929407..930315 Haemophilus influenzae PittEE 5225108 YP_001290667.1 CDS mukB NC_009566.1 930318 931193 D COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; cell division protein MukB 930318..931193 Haemophilus influenzae PittEE 5225062 YP_001290668.1 CDS sbcB NC_009566.1 931206 932627 D Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 931206..932627 Haemophilus influenzae PittEE 5225063 YP_001290669.1 CDS CGSHiEE_04445 NC_009566.1 933316 934593 R COG0642 Signal transduction histidine kinase; phosphate regulon sensor protein PhoR complement(933316..934593) Haemophilus influenzae PittEE 5225064 YP_001290670.1 CDS CGSHiEE_04450 NC_009566.1 934590 935285 R COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; phosphate regulon transcriptional regulatory protein PhoB complement(934590..935285) Haemophilus influenzae PittEE 5225065 YP_001290671.1 CDS CGSHiEE_04455 NC_009566.1 935382 936149 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(935382..936149) Haemophilus influenzae PittEE 5225066 YP_001290672.1 CDS CGSHiEE_04460 NC_009566.1 936159 937007 R COG0581 ABC-type phosphate transport system, permease component; phosphate transport system permease protein PstA complement(936159..937007) Haemophilus influenzae PittEE 5224829 YP_001290673.1 CDS CGSHiEE_04465 NC_009566.1 937009 937884 R COG0573 ABC-type phosphate transport system, permease component; phosphate transport system permease protein PstC complement(937009..937884) Haemophilus influenzae PittEE 5224830 YP_001290674.1 CDS CGSHiEE_04470 NC_009566.1 938049 939068 R COG0226 ABC-type phosphate transport system, periplasmic component; phosphate-binding periplasmic protein PstS complement(938049..939068) Haemophilus influenzae PittEE 5224831 YP_001290675.1 CDS CGSHiEE_04475 NC_009566.1 939573 940061 D COG1528 Ferritin-like protein; ferritin like protein 1 939573..940061 Haemophilus influenzae PittEE 5224832 YP_001290676.1 CDS CGSHiEE_04480 NC_009566.1 940081 940578 D COG1528 Ferritin-like protein; ferritin 940081..940578 Haemophilus influenzae PittEE 5224833 YP_001290677.1 CDS CGSHiEE_04485 NC_009566.1 940823 941587 D COG0463 Glycosyltransferases involved in cell wall biogenesis; hypothetical protein 940823..941587 Haemophilus influenzae PittEE 5224834 YP_001290678.1 CDS sbcB NC_009566.1 941692 943248 D with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 941692..943248 Haemophilus influenzae PittEE 5225563 YP_001290679.1 CDS CGSHiEE_04495 NC_009566.1 943261 943842 D TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 943261..943842 Haemophilus influenzae PittEE 5225564 YP_001290680.1 CDS trpD NC_009566.1 944329 945330 D Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 944329..945330 Haemophilus influenzae PittEE 5225565 YP_001290681.1 CDS CGSHiEE_04515 NC_009566.1 945371 946801 D monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 945371..946801 Haemophilus influenzae PittEE 5225566 YP_001290682.1 CDS CGSHiEE_04520 NC_009566.1 946917 947189 D COG0298 Hydrogenase maturation factor; hydrogenase 2 accessory protein HypG 946917..947189 Haemophilus influenzae PittEE 5225567 YP_001290683.1 CDS valS NC_009566.1 947221 950085 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(947221..950085) Haemophilus influenzae PittEE 5225361 YP_001290684.1 CDS valS NC_009566.1 950133 950771 R COG0525 Valyl-tRNA synthetase; valyl-tRNA synthetase complement(950133..950771) Haemophilus influenzae PittEE 5225362 YP_001290685.1 CDS CGSHiEE_04535 NC_009566.1 950794 951108 R hypothetical protein complement(950794..951108) Haemophilus influenzae PittEE 5225363 YP_001290686.1 CDS CGSHiEE_04540 NC_009566.1 951135 951302 R COG3097 Uncharacterized protein conserved in bacteria; hypothetical protein complement(951135..951302) Haemophilus influenzae PittEE 5225364 YP_001290687.1 CDS CGSHiEE_04545 NC_009566.1 951316 951729 R hypothetical protein complement(951316..951729) Haemophilus influenzae PittEE 5225365 YP_001290688.1 CDS CGSHiEE_04550 NC_009566.1 951719 951889 R COG4185 Uncharacterized protein conserved in bacteria; hypothetical protein complement(951719..951889) Haemophilus influenzae PittEE 5225366 YP_001290689.1 CDS CGSHiEE_04555 NC_009566.1 951974 952408 R binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi complement(951974..952408) Haemophilus influenzae PittEE 5226016 YP_001290690.1 CDS CGSHiEE_04560 NC_009566.1 952500 952673 R COG0136 Aspartate-semialdehyde dehydrogenase; aspartate-semialdehyde dehydrogenase complement(952500..952673) Haemophilus influenzae PittEE 5226017 YP_001290691.1 CDS CGSHiEE_04565 NC_009566.1 953053 953955 D COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases; aspartate-semialdehyde dehydrogenase 953053..953955 Haemophilus influenzae PittEE 5226018 YP_001290692.1 CDS fumC NC_009566.1 954105 955499 D class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 954105..955499 Haemophilus influenzae PittEE 5226019 YP_001290693.1 CDS CGSHiEE_04575 NC_009566.1 955627 956235 D COG0114 Fumarase; hypothetical protein 955627..956235 Haemophilus influenzae PittEE 5226020 YP_001290694.1 CDS fumC NC_009566.1 956333 957157 R COG0613 Predicted metal-dependent phosphoesterases (PHP family); fumarate hydratase complement(956333..957157) Haemophilus influenzae PittEE 5226021 YP_001290695.1 CDS CGSHiEE_04585 NC_009566.1 957157 958176 R catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 complement(957157..958176) Haemophilus influenzae PittEE 5226247 YP_001290696.1 CDS CGSHiEE_04590 NC_009566.1 958659 958841 D COG0167 Dihydroorotate dehydrogenase; hypothetical protein 958659..958841 Haemophilus influenzae PittEE 5226248 YP_001290697.1 CDS CGSHiEE_04595 NC_009566.1 958885 959334 R COG1598 Uncharacterized conserved protein; hypothetical protein complement(958885..959334) Haemophilus influenzae PittEE 5226249 YP_001290698.1 CDS CGSHiEE_04600 NC_009566.1 959366 959548 R COG1724 Predicted periplasmic or secreted lipoprotein; hypothetical protein complement(959366..959548) Haemophilus influenzae PittEE 5226250 YP_001290699.1 CDS CGSHiEE_04605 NC_009566.1 959705 960316 R hypothetical protein complement(959705..960316) Haemophilus influenzae PittEE 5226251 YP_001290700.1 CDS CGSHiEE_04610 NC_009566.1 960364 960660 R COG3646 Uncharacterized phage-encoded protein; hypothetical protein complement(960364..960660) Haemophilus influenzae PittEE 5226252 YP_001290701.1 CDS CGSHiEE_04615 NC_009566.1 960681 960887 R COG1396 Predicted transcriptional regulators; putative Cro repressor complement(960681..960887) Haemophilus influenzae PittEE 5225131 YP_001290702.1 CDS CGSHiEE_04620 NC_009566.1 961018 961674 D COG1396 Predicted transcriptional regulators; putative prophage repressor CI 961018..961674 Haemophilus influenzae PittEE 5225132 YP_001290703.1 CDS CGSHiEE_04625 NC_009566.1 961742 962671 D hypothetical protein 961742..962671 Haemophilus influenzae PittEE 5225133 YP_001290704.1 CDS CGSHiEE_04630 NC_009566.1 962652 963209 D COG0419 ATPase involved in DNA repair; hypothetical protein 962652..963209 Haemophilus influenzae PittEE 5225134 YP_001290705.1 CDS CGSHiEE_04635 NC_009566.1 963630 963800 R hypothetical protein complement(963630..963800) Haemophilus influenzae PittEE 5225135 YP_001290706.1 CDS CGSHiEE_04640 NC_009566.1 963815 964036 D hypothetical protein 963815..964036 Haemophilus influenzae PittEE 5225136 YP_001290707.1 CDS CGSHiEE_04645 NC_009566.1 964204 964419 D hypothetical protein 964204..964419 Haemophilus influenzae PittEE 5225609 YP_001290708.1 CDS CGSHiEE_04650 NC_009566.1 964451 964603 D hypothetical protein 964451..964603 Haemophilus influenzae PittEE 5225610 YP_001290709.1 CDS CGSHiEE_04655 NC_009566.1 964589 964855 R hypothetical protein complement(964589..964855) Haemophilus influenzae PittEE 5225611 YP_001290710.1 CDS CGSHiEE_04660 NC_009566.1 965117 965608 D hypothetical protein 965117..965608 Haemophilus influenzae PittEE 5225612 YP_001290711.1 CDS CGSHiEE_04665 NC_009566.1 965612 965704 D COG3422 Uncharacterized conserved protein; hypothetical protein 965612..965704 Haemophilus influenzae PittEE 5225613 YP_001290712.1 CDS CGSHiEE_04670 NC_009566.1 966042 966293 D phage anti-repressor protein 966042..966293 Haemophilus influenzae PittEE 5225614 YP_001290713.1 CDS CGSHiEE_04675 NC_009566.1 966646 966864 D COG3561 Phage anti-repressor protein; hypothetical protein 966646..966864 Haemophilus influenzae PittEE 5224669 YP_001290714.1 CDS CGSHiEE_04680 NC_009566.1 966861 967259 R integrase/recombinase complement(966861..967259) Haemophilus influenzae PittEE 5224670 YP_001290715.1 CDS CGSHiEE_04685 NC_009566.1 967256 967417 R COG0582 Integrase; integrase/recombinase complement(967256..967417) Haemophilus influenzae PittEE 5224671 YP_001290716.1 CDS CGSHiEE_04690 NC_009566.1 967427 967720 R dihydroorotate dehydrogenase 2 complement(967427..967720) Haemophilus influenzae PittEE 5224672 YP_001290718.1 CDS CGSHiEE_04700 NC_009566.1 968302 969075 D Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 968302..969075 Haemophilus influenzae PittEE 5224674 YP_001290719.1 CDS CGSHiEE_04705 NC_009566.1 969104 969295 D COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases; universal stress protein UspE 969104..969295 Haemophilus influenzae PittEE 5224746 YP_001290720.1 CDS CGSHiEE_04710 NC_009566.1 969276 970124 D with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 969276..970124 Haemophilus influenzae PittEE 5224747 YP_001290721.1 CDS CGSHiEE_04715 NC_009566.1 970326 971162 D COG5266 ABC-type Co2+ transport system, periplasmic component; universal stress protein UspE 970326..971162 Haemophilus influenzae PittEE 5224748 YP_001290722.1 CDS purN NC_009566.1 971246 971884 R glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase complement(971246..971884) Haemophilus influenzae PittEE 5224749 YP_001290723.1 CDS CGSHiEE_04725 NC_009566.1 971939 972973 R catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase complement(971939..972973) Haemophilus influenzae PittEE 5224750 YP_001290724.1 CDS CGSHiEE_04740 NC_009566.1 973929 975122 D catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 973929..975122 Haemophilus influenzae PittEE 5224751 YP_001290725.1 CDS trpA NC_009566.1 975122 975928 D catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 975122..975928 Haemophilus influenzae PittEE 5225811 YP_001290726.1 CDS CGSHiEE_04750 NC_009566.1 976072 977025 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(976072..977025) Haemophilus influenzae PittEE 5225812 YP_001290727.1 CDS CGSHiEE_04755 NC_009566.1 977084 977560 D COG2606 Uncharacterized conserved protein; hypothetical protein 977084..977560 Haemophilus influenzae PittEE 5225813 YP_001290728.1 CDS CGSHiEE_04760 NC_009566.1 977717 977935 R COG1278 Cold shock proteins; aspartate-semialdehyde dehydrogenase complement(977717..977935) Haemophilus influenzae PittEE 5225814 YP_001290729.1 CDS CGSHiEE_04765 NC_009566.1 978082 978240 R COG3140 Uncharacterized protein conserved in bacteria; hypothetical protein complement(978082..978240) Haemophilus influenzae PittEE 5225815 YP_001290730.1 CDS CGSHiEE_04770 NC_009566.1 978233 978952 R catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C complement(978233..978952) Haemophilus influenzae PittEE 5225816 YP_001290731.1 CDS CGSHiEE_04775 NC_009566.1 978946 979266 R COG3098 Uncharacterized protein conserved in bacteria; hypothetical protein complement(978946..979266) Haemophilus influenzae PittEE 5225817 YP_001290732.1 CDS CGSHiEE_04780 NC_009566.1 979281 980738 R Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI complement(979281..980738) Haemophilus influenzae PittEE 5226043 YP_001290733.1 CDS CGSHiEE_04785 NC_009566.1 980897 981151 D catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 980897..981151 Haemophilus influenzae PittEE 5226044 YP_001290734.1 CDS CGSHiEE_04790 NC_009566.1 981151 982041 D COG0142 Geranylgeranyl pyrophosphate synthase; exodeoxyribonuclease VII small subunit 981151..982041 Haemophilus influenzae PittEE 5226045 YP_001290735.1 CDS CGSHiEE_04795 NC_009566.1 982083 983960 D catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 982083..983960 Haemophilus influenzae PittEE 5226046 YP_001290736.1 CDS CGSHiEE_04800 NC_009566.1 983996 984448 R COG2969 Stringent starvation protein B; ClpXP protease specificity-enhancing factor complement(983996..984448) Haemophilus influenzae PittEE 5226047 YP_001290737.1 CDS CGSHiEE_04805 NC_009566.1 984448 985086 R COG0625 Glutathione S-transferase; ClpXP protease specificity-enhancing factor complement(984448..985086) Haemophilus influenzae PittEE 5226048 YP_001290738.1 CDS rpsI NC_009566.1 985266 985658 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(985266..985658) Haemophilus influenzae PittEE 5226049 YP_001290739.1 CDS rplM NC_009566.1 985675 986103 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(985675..986103) Haemophilus influenzae PittEE 5225367 YP_001290740.1 CDS metF NC_009566.1 986568 987446 D MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 986568..987446 Haemophilus influenzae PittEE 5225368 YP_001290741.1 CDS bioD NC_009566.1 987535 988263 R DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase complement(987535..988263) Haemophilus influenzae PittEE 5225369 YP_001290742.1 CDS bioD NC_009566.1 988365 988631 R COG3100 Uncharacterized protein conserved in bacteria; dithiobiotin synthetase complement(988365..988631) Haemophilus influenzae PittEE 5225370 YP_001290743.1 CDS folE NC_009566.1 988692 989348 R involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I complement(988692..989348) Haemophilus influenzae PittEE 5225371 YP_001290744.1 CDS folE NC_009566.1 989485 990699 D COG0303 Molybdopterin biosynthesis enzyme; GTP cyclohydrolase I 989485..990699 Haemophilus influenzae PittEE 5225372 YP_001290745.1 CDS CGSHiEE_04845 NC_009566.1 990703 991434 D ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 990703..991434 Haemophilus influenzae PittEE 5225373 YP_001290746.1 CDS CGSHiEE_04850 NC_009566.1 991571 991825 D highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 991571..991825 Haemophilus influenzae PittEE 5225464 YP_001290747.1 CDS CGSHiEE_04855 NC_009566.1 992007 992477 R COG0526 Thiol-disulfide isomerase and thioredoxins; hypothetical protein complement(992007..992477) Haemophilus influenzae PittEE 5225465 YP_001290748.1 CDS CGSHiEE_04860 NC_009566.1 992522 993163 R COG0785 Cytochrome c biogenesis protein; hypothetical protein complement(992522..993163) Haemophilus influenzae PittEE 5225466 YP_001290749.1 CDS CGSHiEE_04865 NC_009566.1 993175 994236 R COG0225 Peptide methionine sulfoxide reductase; bifunctional methionine sulfoxide reductase A/B protein complement(993175..994236) Haemophilus influenzae PittEE 5225467 YP_001290750.1 CDS CGSHiEE_04870 NC_009566.1 994411 995274 D hypothetical protein 994411..995274 Haemophilus influenzae PittEE 5225468 YP_001290751.1 CDS CGSHiEE_04875 NC_009566.1 995369 995542 R COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; dsDNA-mimic protein complement(995369..995542) Haemophilus influenzae PittEE 5225469 YP_001290752.1 CDS CGSHiEE_04880 NC_009566.1 995552 996097 R Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor complement(995552..996097) Haemophilus influenzae PittEE 5225485 YP_001290753.1 CDS CGSHiEE_04885 NC_009566.1 996224 996373 R hypothetical protein complement(996224..996373) Haemophilus influenzae PittEE 5225486 YP_001290754.1 CDS CGSHiEE_04890 NC_009566.1 996457 996609 R hypothetical protein complement(996457..996609) Haemophilus influenzae PittEE 5225487 YP_001290755.1 CDS CGSHiEE_04895 NC_009566.1 996603 996755 R COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; hypothetical protein complement(996603..996755) Haemophilus influenzae PittEE 5225488 YP_001290756.1 CDS CGSHiEE_04900 NC_009566.1 996981 998345 D hypothetical protein 996981..998345 Haemophilus influenzae PittEE 5225489 YP_001290757.1 CDS CGSHiEE_04905 NC_009566.1 998423 998608 R COG1538 Outer membrane protein; hypothetical protein complement(998423..998608) Haemophilus influenzae PittEE 5225490 YP_001290758.1 CDS CGSHiEE_04910 NC_009566.1 998610 998933 R COG0443 Molecular chaperone; hypothetical protein complement(998610..998933) Haemophilus influenzae PittEE 5225491 YP_001290759.1 CDS CGSHiEE_04915 NC_009566.1 999169 999663 R COG2062 Phosphohistidine phosphatase SixA; hypothetical protein complement(999169..999663) Haemophilus influenzae PittEE 5225853 YP_001290760.1 CDS CGSHiEE_04920 NC_009566.1 999722 1001059 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(999722..1001059) Haemophilus influenzae PittEE 5225854 YP_001290761.1 CDS CGSHiEE_04925 NC_009566.1 1001097 1001924 R COG0294 Dihydropteroate synthase and related enzymes; dihydropteroate synthase complement(1001097..1001924) Haemophilus influenzae PittEE 5225855 YP_001290762.1 CDS CGSHiEE_04940 NC_009566.1 1004035 1004754 R COG0293 23S rRNA methylase; ribosomal RNA large subunit methyltransferase J complement(1004035..1004754) Haemophilus influenzae PittEE 5225856 YP_001290763.1 CDS rrmJ NC_009566.1 1004735 1005091 D COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein; 23S rRNA methyltransferase J 1004735..1005091 Haemophilus influenzae PittEE 5225857 YP_001290764.1 CDS greA NC_009566.1 1005131 1005607 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(1005131..1005607) Haemophilus influenzae PittEE 5226227 YP_001290765.1 CDS CGSHiEE_04955 NC_009566.1 1005771 1007210 D penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase/endopeptidase 1005771..1007210 Haemophilus influenzae PittEE 5226228 YP_001290766.1 CDS CGSHiEE_04960 NC_009566.1 1007262 1007573 D insertion element IS1016 transposase 1007262..1007573 Haemophilus influenzae PittEE 5226229 YP_001290767.1 CDS CGSHiEE_04965 NC_009566.1 1007539 1007910 D COG3676 Transposase and inactivated derivatives; D-alanyl-D-alanine carboxypeptidase/endopeptidase 1007539..1007910 Haemophilus influenzae PittEE 5226230 YP_001290768.2 CDS CGSHiEE_04970 NC_009566.1 <1007983 1008252 R insertion of T, right before stop codon, leading to extension by 24 aa; marked partial; 30S ribosomal protein S15 complement(<1007983..1008252) Haemophilus influenzae PittEE 5226231 YP_001290769.1 CDS CGSHiEE_04975 NC_009566.1 1008388 1008522 R COG0184 Ribosomal protein S15P/S13E; hypothetical protein complement(1008388..1008522) Haemophilus influenzae PittEE 5226232 YP_001290770.1 CDS rpsO NC_009566.1 1008522 1009247 R COG0515 Serine/threonine protein kinase; 30S ribosomal protein S15 complement(1008522..1009247) Haemophilus influenzae PittEE 5226233 YP_001290771.1 CDS CGSHiEE_04985 NC_009566.1 1009486 1009968 R catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-(acyl carrier protein) dehydratase complement(1009486..1009968) Haemophilus influenzae PittEE 5226299 YP_001290772.1 CDS CGSHiEE_04990 NC_009566.1 1010185 1011960 R COG1067 Predicted ATP-dependent protease; 3-hydroxydecanoyl-ACP dehydratase complement(1010185..1011960) Haemophilus influenzae PittEE 5226300 YP_001290773.1 CDS CGSHiEE_04995 NC_009566.1 1012087 1012533 D COG3120 Uncharacterized protein conserved in bacteria; hypothetical protein 1012087..1012533 Haemophilus influenzae PittEE 5226301 YP_001290774.1 CDS CGSHiEE_05000 NC_009566.1 1012602 1014524 R COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member; exodeoxyribonuclease V subunit alpha complement(1012602..1014524) Haemophilus influenzae PittEE 5226302 YP_001290775.1 CDS CGSHiEE_05005 NC_009566.1 1014524 1018159 R COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains); hypothetical protein complement(1014524..1018159) Haemophilus influenzae PittEE 5226303 YP_001290776.1 CDS rplT NC_009566.1 1018272 1018625 R binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 complement(1018272..1018625) Haemophilus influenzae PittEE 5226304 YP_001290777.1 CDS rpmI NC_009566.1 1018691 1018960 R COG0291 Ribosomal protein L35; 50S ribosomal protein L35 complement(1018691..1018960) Haemophilus influenzae PittEE 5225356 YP_001290778.1 CDS CGSHiEE_05020 NC_009566.1 1019099 1019506 R COG0290 Translation initiation factor 3 (IF-3); translation initiation factor IF-3 complement(1019099..1019506) Haemophilus influenzae PittEE 5225357 YP_001290779.1 CDS CGSHiEE_05025 NC_009566.1 1019775 1020587 R related to aldose 1-epimerase; COG0676 Uncharacterized enzymes related to aldose 1-epimerase; hypothetical protein complement(1019775..1020587) Haemophilus influenzae PittEE 5225358 YP_001290780.1 CDS CGSHiEE_05050 NC_009566.1 1022309 1023178 R serine/threonine protein phosphatase family protein complement(1022309..1023178) Haemophilus influenzae PittEE 5225359 YP_001290781.1 CDS CGSHiEE_05055 NC_009566.1 1023254 1024228 R COG0466 ATP-dependent Lon protease, bacterial type; hypothetical protein complement(1023254..1024228) Haemophilus influenzae PittEE 5225360 YP_001290782.1 CDS CGSHiEE_05060 NC_009566.1 1024306 1025067 R COG0631 Serine/threonine protein phosphatase; hypothetical protein complement(1024306..1025067) Haemophilus influenzae PittEE 5225864 YP_001290783.1 CDS CGSHiEE_05065 NC_009566.1 1025067 1025912 R COG0846 NAD-dependent protein deacetylases, SIR2 family; NAD-dependent deacetylase sirtuin 5 complement(1025067..1025912) Haemophilus influenzae PittEE 5225865 YP_001290784.1 CDS CGSHiEE_05070 NC_009566.1 1025909 1026109 R COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins; DNA translocase FtsK complement(1025909..1026109) Haemophilus influenzae PittEE 5225866 YP_001290785.1 CDS CGSHiEE_05075 NC_009566.1 1026328 1027338 D hypothetical protein 1026328..1027338 Haemophilus influenzae PittEE 5225867 YP_001290786.1 CDS CGSHiEE_05080 NC_009566.1 1027386 1028102 R COG3943 Virulence protein; hypothetical protein complement(1027386..1028102) Haemophilus influenzae PittEE 5225868 YP_001290787.1 CDS CGSHiEE_05085 NC_009566.1 1028116 1028610 R COG0462 Phosphoribosylpyrophosphate synthetase; hypothetical protein complement(1028116..1028610) Haemophilus influenzae PittEE 5225869 YP_001290788.1 CDS CGSHiEE_05090 NC_009566.1 1028689 1029399 R COG0846 NAD-dependent protein deacetylases, SIR2 family; NAD-dependent deacetylase complement(1028689..1029399) Haemophilus influenzae PittEE 5226126 YP_001290789.1 CDS CGSHiEE_05095 NC_009566.1 1029383 1029838 R COG4502 Uncharacterized protein conserved in bacteria; putative 5'(3')-deoxyribonucleotidase complement(1029383..1029838) Haemophilus influenzae PittEE 5226127 YP_001290790.1 CDS CGSHiEE_05100 NC_009566.1 1029897 1030850 R COG2378 Predicted transcriptional regulator; hypothetical protein complement(1029897..1030850) Haemophilus influenzae PittEE 5226128 YP_001290791.1 CDS CGSHiEE_05105 NC_009566.1 1030917 1031402 R COG0791 Cell wall-associated hydrolases (invasion-associated proteins); lipoprotein complement(1030917..1031402) Haemophilus influenzae PittEE 5226129 YP_001290792.1 CDS ihfA NC_009566.1 1031455 1031745 R This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha complement(1031455..1031745) Haemophilus influenzae PittEE 5226130 YP_001290793.1 CDS pheT NC_009566.1 1031747 1034134 R catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta complement(1031747..1034134) Haemophilus influenzae PittEE 5226131 YP_001290794.1 CDS pheS NC_009566.1 1034169 1035158 R catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha complement(1034169..1035158) Haemophilus influenzae PittEE 5226132 YP_001290795.1 CDS CGSHiEE_05125 NC_009566.1 1035307 1036047 R COG0016 Phenylalanyl-tRNA synthetase alpha subunit; hypothetical protein complement(1035307..1036047) Haemophilus influenzae PittEE 5226202 YP_001290796.1 CDS pheS NC_009566.1 1036093 1036341 D COG0633 Ferredoxin; phenylalanyl-tRNA synthetase subunit alpha 1036093..1036341 Haemophilus influenzae PittEE 5226203 YP_001290797.1 CDS CGSHiEE_05135 NC_009566.1 1036336 1037148 R catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase complement(1036336..1037148) Haemophilus influenzae PittEE 5226204 YP_001290798.1 CDS CGSHiEE_05140 NC_009566.1 1037284 1037796 R COG1280 Putative threonine efflux protein; threonine efflux protein complement(1037284..1037796) Haemophilus influenzae PittEE 5226205 YP_001290799.1 CDS CGSHiEE_05145 NC_009566.1 1037796 1038287 R COG1267 Phosphatidylglycerophosphatase A and related proteins; phosphatidylglycerophosphatase A complement(1037796..1038287) Haemophilus influenzae PittEE 5226206 YP_001290800.1 CDS CGSHiEE_05150 NC_009566.1 1038284 1039270 R COG0611 Thiamine monophosphate kinase; dihydrodipicolinate reductase complement(1038284..1039270) Haemophilus influenzae PittEE 5226207 YP_001290801.1 CDS nusB NC_009566.1 1039337 1039771 R Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB complement(1039337..1039771) Haemophilus influenzae PittEE 5225832 YP_001290802.1 CDS ribH NC_009566.1 1039775 1040248 R RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase complement(1039775..1040248) Haemophilus influenzae PittEE 5225833 YP_001290803.1 CDS asnC NC_009566.1 1040475 1041878 D catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 1040475..1041878 Haemophilus influenzae PittEE 5225834 YP_001290804.1 CDS CGSHiEE_05170 NC_009566.1 1041954 1042643 D COG0288 Carbonic anhydrase; putative carbonic anhydrase 1041954..1042643 Haemophilus influenzae PittEE 5225835 YP_001290805.1 CDS CGSHiEE_05190 NC_009566.1 1043743 1044099 D hypothetical protein 1043743..1044099 Haemophilus influenzae PittEE 5225836 YP_001290806.1 CDS CGSHiEE_05195 NC_009566.1 1044310 1044405 D COG0488 ATPase components of ABC transporters with duplicated ATPase domains; ABC transporter ATPase 1044310..1044405 Haemophilus influenzae PittEE 5225882 YP_001290807.1 CDS CGSHiEE_05200 NC_009566.1 1044769 1046199 R catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase complement(1044769..1046199) Haemophilus influenzae PittEE 5225883 YP_001290808.1 CDS CGSHiEE_05215 NC_009566.1 1047306 1049204 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 1047306..1049204 Haemophilus influenzae PittEE 5225884 YP_001290809.1 CDS CGSHiEE_05230 NC_009566.1 1051557 1052771 D COG0786 Na+/glutamate symporter; sodium/glutamate symport carrier protein 1051557..1052771 Haemophilus influenzae PittEE 5225885 YP_001290810.1 CDS CGSHiEE_05235 NC_009566.1 1052809 1053705 R COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); DNA topoisomerase IV subunit A complement(1052809..1053705) Haemophilus influenzae PittEE 5226140 YP_001290811.1 CDS grxA NC_009566.1 1053834 1054097 D functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 1 1053834..1054097 Haemophilus influenzae PittEE 5226141 YP_001290812.1 CDS CGSHiEE_05245 NC_009566.1 1054160 1055380 R FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase I complement(1054160..1055380) Haemophilus influenzae PittEE 5226142 YP_001290813.1 CDS mnmC NC_009566.1 1055527 1057539 D catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 1055527..1057539 Haemophilus influenzae PittEE 5226143 YP_001290814.1 CDS CGSHiEE_05255 NC_009566.1 1057627 1058622 D hypothetical protein 1057627..1058622 Haemophilus influenzae PittEE 5226144 YP_001290815.1 CDS CGSHiEE_05260 NC_009566.1 1058622 1059500 D COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; lic-1 operon protein 1058622..1059500 Haemophilus influenzae PittEE 5226145 YP_001290816.1 CDS CGSHiEE_05265 NC_009566.1 1059497 1060198 D COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes; lic-1 operon protein 1059497..1060198 Haemophilus influenzae PittEE 5226146 YP_001290817.1 CDS CGSHiEE_05290 NC_009566.1 1063077 1063532 D COG0778 Nitroreductase; hypothetical protein 1063077..1063532 Haemophilus influenzae PittEE 5225759 YP_001290818.1 CDS CGSHiEE_05295 NC_009566.1 1063580 1064134 R COG3381 Uncharacterized component of anaerobic dehydrogenases; putative component of anaerobic dehydrogenase complement(1063580..1064134) Haemophilus influenzae PittEE 5225760 YP_001290819.1 CDS CGSHiEE_05300 NC_009566.1 1064127 1064741 R COG2249 Putative NADPH-quinone reductase (modulator of drug activity B); putative NAD(P)H oxidoreductase complement(1064127..1064741) Haemophilus influenzae PittEE 5225761 YP_001290820.1 CDS CGSHiEE_05305 NC_009566.1 1064862 1066106 R involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT complement(1064862..1066106) Haemophilus influenzae PittEE 5225762 YP_001290821.1 CDS mnmC NC_009566.1 1066389 1066829 D COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases); 5-methylaminomethyl-2-thiouridine methyltransferase 1066389..1066829 Haemophilus influenzae PittEE 5225763 YP_001290822.1 CDS CGSHiEE_05315 NC_009566.1 1066899 1067987 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(1066899..1067987) Haemophilus influenzae PittEE 5224698 YP_001290823.1 CDS CGSHiEE_05320 NC_009566.1 1068206 1069456 R part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE complement(1068206..1069456) Haemophilus influenzae PittEE 5224699 YP_001290824.1 CDS CGSHiEE_05325 NC_009566.1 1069456 1070139 R COG1136 ABC-type antimicrobial peptide transport system, ATPase component; outer membrane-specific lipoprotein transporter subunit LolE complement(1069456..1070139) Haemophilus influenzae PittEE 5224700 YP_001290825.1 CDS bioD NC_009566.1 1070221 1070862 R DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase complement(1070221..1070862) Haemophilus influenzae PittEE 5224701 YP_001290826.1 CDS CGSHiEE_05335 NC_009566.1 1070872 1071654 R COG0500 SAM-dependent methyltransferases; biotin synthesis protein complement(1070872..1071654) Haemophilus influenzae PittEE 5224702 YP_001290827.1 CDS bioD NC_009566.1 1071642 1072289 R COG2830 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1071642..1072289) Haemophilus influenzae PittEE 5224703 YP_001290828.1 CDS CGSHiEE_05345 NC_009566.1 1072299 1073441 R catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase complement(1072299..1073441) Haemophilus influenzae PittEE 5225632 YP_001290829.1 CDS CGSHiEE_05350 NC_009566.1 1073450 1074739 R catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine--8-amino-7-oxononanoate transaminase complement(1073450..1074739) Haemophilus influenzae PittEE 5225633 YP_001290830.1 CDS CGSHiEE_05355 NC_009566.1 1074761 1075942 R COG4591 ABC-type transport system, involved in lipoprotein release, permease component; adenosylmethionine--8-amino-7-oxononanoate transaminase complement(1074761..1075942) Haemophilus influenzae PittEE 5225634 YP_001290831.1 CDS CGSHiEE_05360 NC_009566.1 1075942 1076889 R Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor; glycerate dehydrogenase complement(1075942..1076889) Haemophilus influenzae PittEE 5225635 YP_001290832.1 CDS CGSHiEE_05365 NC_009566.1 1076949 1077803 R catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase complement(1076949..1077803) Haemophilus influenzae PittEE 5225636 YP_001290833.1 CDS CGSHiEE_05370 NC_009566.1 1077818 1078621 R COG2912 Uncharacterized conserved protein; hypothetical protein complement(1077818..1078621) Haemophilus influenzae PittEE 5225637 YP_001290834.1 CDS CGSHiEE_05375 NC_009566.1 1078621 1079499 R COG2890 Methylase of polypeptide chain release factors; hypothetical protein complement(1078621..1079499) Haemophilus influenzae PittEE 5225638 YP_001290835.1 CDS CGSHiEE_05380 NC_009566.1 1079499 1079939 R COG1714 Predicted membrane protein/domain; hypothetical protein complement(1079499..1079939) Haemophilus influenzae PittEE 5225691 YP_001290836.1 CDS prfA NC_009566.1 1079992 1081077 R recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 complement(1079992..1081077) Haemophilus influenzae PittEE 5225692 YP_001290837.1 CDS CGSHiEE_05390 NC_009566.1 1081184 1082236 R COG0790 FOG: TPR repeat, SEL1 subfamily; hypothetical protein complement(1081184..1082236) Haemophilus influenzae PittEE 5225693 YP_001290838.1 CDS CGSHiEE_05395 NC_009566.1 1082236 1083000 R COG0790 FOG: TPR repeat, SEL1 subfamily; Sel1 repeat-containing protein complement(1082236..1083000) Haemophilus influenzae PittEE 5225694 YP_001290839.1 CDS CGSHiEE_05400 NC_009566.1 1083013 1084224 R COG2333 Predicted hydrolase (metallo-beta-lactamase superfamily); hypothetical protein complement(1083013..1084224) Haemophilus influenzae PittEE 5225695 YP_001290840.1 CDS CGSHiEE_05405 NC_009566.1 1084224 1085378 R COG0790 FOG: TPR repeat, SEL1 subfamily; Sel1 domain-containing protein complement(1084224..1085378) Haemophilus influenzae PittEE 5225696 YP_001290841.1 CDS CGSHiEE_05410 NC_009566.1 1085531 1086067 R COG3101 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1085531..1086067) Haemophilus influenzae PittEE 5225704 YP_001290842.1 CDS CGSHiEE_05415 NC_009566.1 1086458 1086592 R hypothetical protein complement(1086458..1086592) Haemophilus influenzae PittEE 5225705 YP_001290843.1 CDS CGSHiEE_05420 NC_009566.1 1086811 1087002 R hypothetical protein complement(1086811..1087002) Haemophilus influenzae PittEE 5225706 YP_001290844.1 CDS CGSHiEE_05425 NC_009566.1 1087153 1087821 R COG5005 Mu-like prophage protein gpG; hypothetical protein complement(1087153..1087821) Haemophilus influenzae PittEE 5225707 YP_001290845.1 CDS CGSHiEE_05430 NC_009566.1 1087880 1088113 R hypothetical protein complement(1087880..1088113) Haemophilus influenzae PittEE 5225708 YP_001290846.1 CDS CGSHiEE_05435 NC_009566.1 1088113 1088643 D COG4383 Mu-like prophage protein gp29; hypothetical protein 1088113..1088643 Haemophilus influenzae PittEE 5225709 YP_001290847.1 CDS prfA NC_009566.1 1088751 1089041 R COG0582 Integrase; peptide chain release factor 1 complement(1088751..1089041) Haemophilus influenzae PittEE 5225710 YP_001290848.1 CDS CGSHiEE_05445 NC_009566.1 1089578 1091014 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1089578..1091014 Haemophilus influenzae PittEE 5226001 YP_001290849.1 CDS alr NC_009566.1 1092572 1093654 D converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 1092572..1093654 Haemophilus influenzae PittEE 5226002 YP_001290850.1 CDS pgi NC_009566.1 1093751 1095400 D functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 1093751..1095400 Haemophilus influenzae PittEE 5226003 YP_001290851.1 CDS CGSHiEE_05475 NC_009566.1 1095635 1095733 D hypothetical protein 1095635..1095733 Haemophilus influenzae PittEE 5226004 YP_001290852.1 CDS CGSHiEE_05480 NC_009566.1 1095735 1095971 D COG0166 Glucose-6-phosphate isomerase; hypothetical protein 1095735..1095971 Haemophilus influenzae PittEE 5225858 YP_001290853.1 CDS CGSHiEE_05495 NC_009566.1 1097206 1097670 R outer membrane lipoprotein PCP complement(1097206..1097670) Haemophilus influenzae PittEE 5225859 YP_001290854.1 CDS pgi NC_009566.1 1097693 1097989 R COG3133 Outer membrane lipoprotein; glucose-6-phosphate isomerase complement(1097693..1097989) Haemophilus influenzae PittEE 5225860 YP_001290855.1 CDS argS NC_009566.1 1098643 1100376 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1098643..1100376 Haemophilus influenzae PittEE 5225861 YP_001290856.1 CDS ilvH NC_009566.1 1100662 1101153 R with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit complement(1100662..1101153) Haemophilus influenzae PittEE 5225862 YP_001290857.1 CDS CGSHiEE_05525 NC_009566.1 1101153 1102874 R acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 3 catalytic subunit complement(1101153..1102874) Haemophilus influenzae PittEE 5225863 YP_001290858.1 CDS CGSHiEE_05530 NC_009566.1 1102924 1103073 R COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; hypothetical protein complement(1102924..1103073) Haemophilus influenzae PittEE 5226293 YP_001290859.1 CDS CGSHiEE_05535 NC_009566.1 1103141 1104661 R COG1757 Na+/H+ antiporter; Na+/H+ antiporter complement(1103141..1104661) Haemophilus influenzae PittEE 5226294 YP_001290860.1 CDS CGSHiEE_05540 NC_009566.1 1105104 1105472 D COG2916 DNA-binding protein H-NS; acetolactate synthase 3 catalytic subunit 1105104..1105472 Haemophilus influenzae PittEE 5226295 YP_001290861.1 CDS purU NC_009566.1 1105577 1106413 D produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 1105577..1106413 Haemophilus influenzae PittEE 5226296 YP_001290862.1 CDS CGSHiEE_05550 NC_009566.1 1106413 1107711 D catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1106413..1107711 Haemophilus influenzae PittEE 5226297 YP_001290863.1 CDS CGSHiEE_05565 NC_009566.1 1109201 1110268 D COG0438 Glycosyltransferase; hypothetical protein 1109201..1110268 Haemophilus influenzae PittEE 5226298 YP_001290864.1 CDS CGSHiEE_05570 NC_009566.1 1110411 1111772 R COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase; recombination factor protein RarA complement(1110411..1111772) Haemophilus influenzae PittEE 5226170 YP_001290865.1 CDS lolA NC_009566.1 1111833 1112450 R participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein complement(1111833..1112450) Haemophilus influenzae PittEE 5226171 YP_001290866.1 CDS lolA NC_009566.1 1112468 1115236 R COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins; outer-membrane lipoprotein carrier protein complement(1112468..1115236) Haemophilus influenzae PittEE 5226172 YP_001290867.1 CDS CGSHiEE_05585 NC_009566.1 1115238 1115717 R mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator complement(1115238..1115717) Haemophilus influenzae PittEE 5226173 YP_001290868.1 CDS CGSHiEE_05590 NC_009566.1 1115797 1117173 R Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA complement(1115797..1117173) Haemophilus influenzae PittEE 5226174 YP_001290869.1 CDS CGSHiEE_05595 NC_009566.1 1117406 1118452 R COG3025 Uncharacterized conserved protein; hypothetical protein complement(1117406..1118452) Haemophilus influenzae PittEE 5226175 YP_001290870.1 CDS CGSHiEE_05600 NC_009566.1 1118977 1123743 D COG3210 Large exoproteins involved in heme utilization or adhesion; HMW2A, high molecular weight adhesin 2 1118977..1123743 Haemophilus influenzae PittEE 5226305 YP_001290871.1 CDS CGSHiEE_05605 NC_009566.1 1123895 1125532 D COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component; HMW1B, OMP-85-like protein required for secretion of HMW1A and HMW2A 1123895..1125532 Haemophilus influenzae PittEE 5226306 YP_001290872.1 CDS CGSHiEE_05610 NC_009566.1 1125747 1127699 D COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family; HMW1C, putative glycosyltransferase involved in glycosylation of HMW1A and HMW2A 1125747..1127699 Haemophilus influenzae PittEE 5226307 YP_001290873.1 CDS CGSHiEE_05615 NC_009566.1 1127888 1128052 D hypothetical protein 1127888..1128052 Haemophilus influenzae PittEE 5226308 YP_001290874.1 CDS CGSHiEE_05620 NC_009566.1 1128502 1128618 R COG0675 Transposase and inactivated derivatives; hypothetical protein complement(1128502..1128618) Haemophilus influenzae PittEE 5226309 YP_001290875.1 CDS CGSHiEE_05625 NC_009566.1 1129017 1129181 R COG2801 Transposase and inactivated derivatives; hypothetical protein complement(1129017..1129181) Haemophilus influenzae PittEE 5226310 YP_001290876.1 CDS CGSHiEE_05630 NC_009566.1 1129311 1129649 R putative ABC-type chelated iron transport system, permease complement(1129311..1129649) Haemophilus influenzae PittEE 5226311 YP_001290877.1 CDS CGSHiEE_05635 NC_009566.1 1129717 1129905 D COG5566 Uncharacterized conserved protein; hypothetical protein 1129717..1129905 Haemophilus influenzae PittEE 5225789 YP_001290878.1 CDS CGSHiEE_05640 NC_009566.1 1130292 1131008 R COG3219 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1130292..1131008) Haemophilus influenzae PittEE 5225790 YP_001290879.1 CDS CGSHiEE_05645 NC_009566.1 1130998 1131921 R COG3220 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1130998..1131921) Haemophilus influenzae PittEE 5225791 YP_001290880.1 CDS CGSHiEE_05650 NC_009566.1 1131982 1132269 R COG3767 Uncharacterized low-complexity protein; hypothetical protein complement(1131982..1132269) Haemophilus influenzae PittEE 5225792 YP_001290881.1 CDS CGSHiEE_05665 NC_009566.1 1132973 1133653 D COG1392 Phosphate transport regulator (distant homolog of PhoU); phosphate transport regulator 1132973..1133653 Haemophilus influenzae PittEE 5225793 YP_001290882.1 CDS CGSHiEE_05670 NC_009566.1 1133678 1134940 D COG0306 Phosphate/sulphate permeases; putative phosphate permease 1133678..1134940 Haemophilus influenzae PittEE 5225794 YP_001290883.1 CDS CGSHiEE_05675 NC_009566.1 1135006 1135617 D COG3103 SH3 domain protein; hypothetical protein 1135006..1135617 Haemophilus influenzae PittEE 5226214 YP_001290884.1 CDS cca NC_009566.1 1135624 1136874 D catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 1135624..1136874 Haemophilus influenzae PittEE 5226215 YP_001290885.1 CDS lolB NC_009566.1 1136946 1137566 D Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB 1136946..1137566 Haemophilus influenzae PittEE 5226216 YP_001290886.1 CDS ipk NC_009566.1 1137566 1138519 D An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1137566..1138519 Haemophilus influenzae PittEE 5226217 YP_001290887.1 CDS CGSHiEE_05695 NC_009566.1 1138521 1139468 D catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1138521..1139468 Haemophilus influenzae PittEE 5226218 YP_001290888.1 CDS CGSHiEE_05710 NC_009566.1 1140923 1141639 R Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A complement(1140923..1141639) Haemophilus influenzae PittEE 5226219 YP_001290889.1 CDS CGSHiEE_05715 NC_009566.1 1141648 1143042 R NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein complement(1141648..1143042) Haemophilus influenzae PittEE 5226208 YP_001290890.1 CDS CGSHiEE_05720 NC_009566.1 1143086 1143700 D catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1143086..1143700 Haemophilus influenzae PittEE 5226209 YP_001290891.1 CDS pepN NC_009566.1 1143772 1146381 R COG0308 Aminopeptidase N; aminopeptidase N complement(1143772..1146381) Haemophilus influenzae PittEE 5226210 YP_001290892.1 CDS CGSHiEE_05730 NC_009566.1 1146425 1146769 R hypothetical protein complement(1146425..1146769) Haemophilus influenzae PittEE 5226211 YP_001290893.1 CDS CGSHiEE_05735 NC_009566.1 1146766 1147014 R COG0024 Methionine aminopeptidase; hypothetical protein complement(1146766..1147014) Haemophilus influenzae PittEE 5226212 YP_001290894.1 CDS CGSHiEE_05740 NC_009566.1 1147185 1147679 D COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; riboflavin synthase subunit alpha 1147185..1147679 Haemophilus influenzae PittEE 5226213 YP_001290895.1 CDS CGSHiEE_05745 NC_009566.1 1147749 1148837 D With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 1147749..1148837 Haemophilus influenzae PittEE 5225395 YP_001290896.1 CDS CGSHiEE_05750 NC_009566.1 1148976 1150166 D catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 1148976..1150166 Haemophilus influenzae PittEE 5225396 YP_001290897.1 CDS CGSHiEE_05755 NC_009566.1 1150273 1150899 R COG1122 ABC-type cobalt transport system, ATPase component; cobalt ABC transporter ATPase complement(1150273..1150899) Haemophilus influenzae PittEE 5225397 YP_001290898.1 CDS CGSHiEE_05760 NC_009566.1 1150901 1151533 R COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters; aromatic-amino-acid aminotransferase complement(1150901..1151533) Haemophilus influenzae PittEE 5225398 YP_001290899.1 CDS CGSHiEE_05765 NC_009566.1 1151533 1152153 R catalyzes the ATP-dependent transport of cobalt; cobalt transport protein CbiM complement(1151533..1152153) Haemophilus influenzae PittEE 5225399 YP_001290900.1 CDS CGSHiEE_05770 NC_009566.1 1152153 1152641 R COG0013 Alanyl-tRNA synthetase; hypothetical protein complement(1152153..1152641) Haemophilus influenzae PittEE 5225400 YP_001290901.1 CDS CGSHiEE_05775 NC_009566.1 1152654 1153337 R COG5266 ABC-type Co2+ transport system, periplasmic component; putative ABC-type Co2+ transport system, periplasmic component complement(1152654..1153337) Haemophilus influenzae PittEE 5225401 YP_001290902.1 CDS CGSHiEE_05780 NC_009566.1 1153427 1153834 D COG0789 Predicted transcriptional regulators; HTH-type transcriptional regulator 1153427..1153834 Haemophilus influenzae PittEE 5225548 YP_001290903.1 CDS CGSHiEE_05785 NC_009566.1 1153849 1154391 R COG0790 FOG: TPR repeat, SEL1 subfamily; hypothetical protein complement(1153849..1154391) Haemophilus influenzae PittEE 5225549 YP_001290904.1 CDS CGSHiEE_05800 NC_009566.1 1155219 1155569 D COG0251 Putative translation initiation inhibitor, yjgF family; putative translation initiation inhibitor, YjgF family protein 1155219..1155569 Haemophilus influenzae PittEE 5225550 YP_001290905.1 CDS CGSHiEE_05805 NC_009566.1 1155600 1156016 D COG3105 Uncharacterized protein conserved in bacteria; hypothetical protein 1155600..1156016 Haemophilus influenzae PittEE 5225551 YP_001290906.1 CDS CGSHiEE_05810 NC_009566.1 1156063 1156668 R COG0586 Uncharacterized membrane-associated protein; cobalt transport protein CbiM complement(1156063..1156668) Haemophilus influenzae PittEE 5225552 YP_001290907.1 CDS CGSHiEE_05815 NC_009566.1 1156887 1157174 D the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 1156887..1157174 Haemophilus influenzae PittEE 5225553 YP_001290909.1 CDS CGSHiEE_05825 NC_009566.1 1158021 1158386 D COG0527 Aspartokinases; 50S ribosomal protein L25 1158021..1158386 Haemophilus influenzae PittEE 5226030 YP_001290910.1 CDS CGSHiEE_05830 NC_009566.1 1158515 1159813 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 1158515..1159813 Haemophilus influenzae PittEE 5226031 YP_001290911.1 CDS dapD NC_009566.1 1159873 1160700 R catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase complement(1159873..1160700) Haemophilus influenzae PittEE 5226032 YP_001290913.1 CDS dapD NC_009566.1 1161063 1162073 D binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 1161063..1162073 Haemophilus influenzae PittEE 5226034 YP_001290914.1 CDS CGSHiEE_05850 NC_009566.1 1162256 1164895 D catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 1162256..1164895 Haemophilus influenzae PittEE 5226035 YP_001290915.1 CDS CGSHiEE_05855 NC_009566.1 1165040 1165168 R COG2801 Transposase and inactivated derivatives; transposase complement(1165040..1165168) Haemophilus influenzae PittEE 5226057 YP_001290916.1 CDS CGSHiEE_05860 NC_009566.1 1165169 1165288 R COG2801 Transposase and inactivated derivatives; transposase complement(1165169..1165288) Haemophilus influenzae PittEE 5226058 YP_001290917.1 CDS CGSHiEE_05865 NC_009566.1 1165748 1166977 D COG0270 Site-specific DNA methylase; modification methylase 1165748..1166977 Haemophilus influenzae PittEE 5226059 YP_001290918.1 CDS CGSHiEE_05870 NC_009566.1 1166980 1167963 D COG3440 Predicted restriction endonuclease; putative type II restriction endonuclease 1166980..1167963 Haemophilus influenzae PittEE 5226060 YP_001290919.1 CDS CGSHiEE_05875 NC_009566.1 1168007 1169419 R COG3106 Predicted ATPase; hypothetical protein complement(1168007..1169419) Haemophilus influenzae PittEE 5226061 YP_001290920.1 CDS CGSHiEE_05880 NC_009566.1 1169489 1171183 D COG4166 ABC-type oligopeptide transport system, periplasmic component; anti peptide resistance ABC transporter periplasmic protein 1169489..1171183 Haemophilus influenzae PittEE 5226062 YP_001290921.1 CDS CGSHiEE_05885 NC_009566.1 1171183 1172148 D COG4168 ABC-type antimicrobial peptide transport system, permease component; peptide ABC transporter permease protein 1171183..1172148 Haemophilus influenzae PittEE 5226063 YP_001290922.1 CDS CGSHiEE_05900 NC_009566.1 1173030 1174079 D COG4170 ABC-type antimicrobial peptide transport system, ATPase component; peptide ABC transporter ATP-binding protein 1173030..1174079 Haemophilus influenzae PittEE 5225639 YP_001290923.1 CDS CGSHiEE_05905 NC_009566.1 1174079 1174888 D COG4167 ABC-type antimicrobial peptide transport system, ATPase component; anti peptide resistance ABC transporter ATPase 1174079..1174888 Haemophilus influenzae PittEE 5225640 YP_001290924.1 CDS CGSHiEE_05910 NC_009566.1 1174900 1175916 D COG2855 Predicted membrane protein; phosphoenolpyruvate carboxylase 1174900..1175916 Haemophilus influenzae PittEE 5225641 YP_001290925.1 CDS CGSHiEE_05925 NC_009566.1 1177055 1178056 D catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 1177055..1178056 Haemophilus influenzae PittEE 5225642 YP_001290926.1 CDS CGSHiEE_05930 NC_009566.1 1178091 1178186 R COG0158 Fructose-1,6-bisphosphatase; cytidylate kinase complement(1178091..1178186) Haemophilus influenzae PittEE 5225643 YP_001290927.1 CDS CGSHiEE_05935 NC_009566.1 1178460 1180058 D COG1620 L-lactate permease; putative L-lactate permease 1178460..1180058 Haemophilus influenzae PittEE 5225900 YP_001290928.1 CDS CGSHiEE_05950 NC_009566.1 1183191 1183880 R enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase complement(1183191..1183880) Haemophilus influenzae PittEE 5225901 YP_001290929.1 CDS CGSHiEE_05955 NC_009566.1 1183877 1184572 R COG0526 Thiol-disulfide isomerase and thioredoxins; hypothetical protein complement(1183877..1184572) Haemophilus influenzae PittEE 5225902 YP_001290930.1 CDS CGSHiEE_05960 NC_009566.1 1184577 1184762 R COG0608 Single-stranded DNA-specific exonuclease; single-stranded-DNA-specific exonuclease RecJ complement(1184577..1184762) Haemophilus influenzae PittEE 5225903 YP_001290931.1 CDS CGSHiEE_05965 NC_009566.1 1184710 1186305 R COG0608 Single-stranded DNA-specific exonuclease; single-stranded-DNA-specific exonuclease RecJ complement(1184710..1186305) Haemophilus influenzae PittEE 5225904 YP_001290932.1 CDS CGSHiEE_05970 NC_009566.1 1186590 1187279 R COG1651 Protein-disulfide isomerase; thiol-disulfide interchange protein complement(1186590..1187279) Haemophilus influenzae PittEE 5225905 YP_001290933.1 CDS CGSHiEE_05975 NC_009566.1 1187764 1188510 D COG1186 Protein chain release factor B; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1187764..1188510 Haemophilus influenzae PittEE 5225777 YP_001290934.1 CDS lysS NC_009566.1 1188623 1190131 D class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 1188623..1190131 Haemophilus influenzae PittEE 5225778 YP_001290935.1 CDS CGSHiEE_05985 NC_009566.1 1190217 1191152 R oxidizes malate to oxaloacetate; malate dehydrogenase complement(1190217..1191152) Haemophilus influenzae PittEE 5225779 YP_001290936.1 CDS CGSHiEE_05990 NC_009566.1 1191359 1191814 D regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 1191359..1191814 Haemophilus influenzae PittEE 5225780 YP_001290937.1 CDS CGSHiEE_05995 NC_009566.1 1191814 1192704 D COG1090 Predicted nucleoside-diphosphate sugar epimerase; arginine repressor 1191814..1192704 Haemophilus influenzae PittEE 5225781 YP_001290938.1 CDS CGSHiEE_06000 NC_009566.1 1192761 1194278 R Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase complement(1192761..1194278) Haemophilus influenzae PittEE 5225782 YP_001290939.1 CDS CGSHiEE_06015 NC_009566.1 1194868 1195311 R COG3092 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1194868..1195311) Haemophilus influenzae PittEE 5225783 YP_001290940.1 CDS CGSHiEE_06020 NC_009566.1 1195529 1196734 D AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 1195529..1196734 Haemophilus influenzae PittEE 5226154 YP_001290941.1 CDS CGSHiEE_06025 NC_009566.1 1196802 1198937 D catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 1196802..1198937 Haemophilus influenzae PittEE 5226155 YP_001290942.1 CDS CGSHiEE_06030 NC_009566.1 1199015 1199518 R COG2840 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1199015..1199518) Haemophilus influenzae PittEE 5226156 YP_001290943.1 CDS CGSHiEE_06035 NC_009566.1 1199648 1200592 D involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1199648..1200592 Haemophilus influenzae PittEE 5226157 YP_001290944.1 CDS cysB NC_009566.1 1200651 1201622 R LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB complement(1200651..1201622) Haemophilus influenzae PittEE 5226158 YP_001290945.1 CDS CGSHiEE_06045 NC_009566.1 1201633 1202706 R COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; ribosomal large subunit pseudouridine synthase B complement(1201633..1202706) Haemophilus influenzae PittEE 5226159 YP_001290946.1 CDS CGSHiEE_06050 NC_009566.1 1202754 1203377 R COG0009 Putative translation factor (SUA5); hypothetical protein complement(1202754..1203377) Haemophilus influenzae PittEE 5224662 YP_001290947.1 CDS CGSHiEE_06055 NC_009566.1 1203498 1204379 R COG0074 Succinyl-CoA synthetase, alpha subunit; succinyl-CoA synthetase subunit alpha complement(1203498..1204379) Haemophilus influenzae PittEE 5224663 YP_001290948.1 CDS cysB NC_009566.1 1204379 1205548 R catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta complement(1204379..1205548) Haemophilus influenzae PittEE 5224664 YP_001290949.1 CDS CGSHiEE_06065 NC_009566.1 1205584 1206675 R COG2933 Predicted SAM-dependent methyltransferase; putative RNA 2'-O-ribose methyltransferase complement(1205584..1206675) Haemophilus influenzae PittEE 5224665 YP_001290950.1 CDS CGSHiEE_06070 NC_009566.1 1206668 1207561 R Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA complement(1206668..1207561) Haemophilus influenzae PittEE 5224666 YP_001290951.1 CDS CGSHiEE_06075 NC_009566.1 1208037 1209068 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 1208037..1209068 Haemophilus influenzae PittEE 5224667 YP_001290952.1 CDS CGSHiEE_06080 NC_009566.1 1209119 1209262 R COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; hypothetical protein complement(1209119..1209262) Haemophilus influenzae PittEE 5224668 YP_001290953.1 CDS CGSHiEE_06085 NC_009566.1 1209419 1210102 D COG0603 Predicted PP-loop superfamily ATPase; PP-loop superfamily ATPase 1209419..1210102 Haemophilus influenzae PittEE 5225685 YP_001290954.1 CDS CGSHiEE_06090 NC_009566.1 1210095 1210520 D COG0720 6-pyruvoyl-tetrahydropterin synthase; 6-pyruvoyl tetrahydrobiopterin synthase 1210095..1210520 Haemophilus influenzae PittEE 5225686 YP_001290955.1 CDS CGSHiEE_06095 NC_009566.1 1210521 1211156 D COG0602 Organic radical activating enzymes; organic radical activating protein 1210521..1211156 Haemophilus influenzae PittEE 5225687 YP_001290956.1 CDS CGSHiEE_06100 NC_009566.1 1211402 1211788 D COG0327 Uncharacterized conserved protein; branched-chain amino acid aminotransferase 1211402..1211788 Haemophilus influenzae PittEE 5225688 YP_001290957.1 CDS uvrD NC_009566.1 1211775 1213955 D unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 1211775..1213955 Haemophilus influenzae PittEE 5225689 YP_001290958.1 CDS uvrD NC_009566.1 1215062 1215949 D COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; DNA-dependent helicase II 1215062..1215949 Haemophilus influenzae PittEE 5225690 YP_001290959.1 CDS dppD NC_009566.1 1215959 1216951 D DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit 1215959..1216951 Haemophilus influenzae PittEE 5226321 YP_001290960.1 CDS dppF NC_009566.1 1216954 1217937 D Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit 1216954..1217937 Haemophilus influenzae PittEE 5226322 YP_001290961.1 CDS CGSHiEE_06135 NC_009566.1 1217966 1218661 R catalyzes the formation of a phosphodiester at the site of a single-strand break in duplex DNA; DNA ligase complement(1217966..1218661) Haemophilus influenzae PittEE 5226323 YP_001290962.1 CDS gmhA NC_009566.1 1218979 1219563 D catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 1218979..1219563 Haemophilus influenzae PittEE 5226324 YP_001290963.1 CDS artP NC_009566.1 1219689 1220420 D With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit 1219689..1220420 Haemophilus influenzae PittEE 5226325 YP_001290964.1 CDS artP NC_009566.1 1220438 1221157 D COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; arginine transporter ATP-binding protein 1220438..1221157 Haemophilus influenzae PittEE 5226326 YP_001290965.1 CDS CGSHiEE_06155 NC_009566.1 1221161 1221826 D with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ 1221161..1221826 Haemophilus influenzae PittEE 5226327 YP_001290966.1 CDS artM NC_009566.1 1221826 1222509 D with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM 1221826..1222509 Haemophilus influenzae PittEE 5225625 YP_001290967.1 CDS CGSHiEE_06165 NC_009566.1 1222715 1223026 D COG5295 Autotransporter adhesin; hypothetical protein 1222715..1223026 Haemophilus influenzae PittEE 5225626 YP_001290968.1 CDS artM NC_009566.1 1223124 1223636 R COG3637 Opacity protein and related surface antigens; opacity protein complement(1223124..1223636) Haemophilus influenzae PittEE 5225627 YP_001290969.1 CDS CGSHiEE_06175 NC_009566.1 1223766 1224203 R COG3091 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1223766..1224203) Haemophilus influenzae PittEE 5225628 YP_001290970.1 CDS CGSHiEE_06180 NC_009566.1 1224493 1225647 R catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase complement(1224493..1225647) Haemophilus influenzae PittEE 5225629 YP_001290971.1 CDS CGSHiEE_06185 NC_009566.1 1225732 1226313 R catalyzes the formation of anthranilate from chorismate and glutamine; functions in tryptophan biosynthesis; putative anthranilate synthase component II complement(1225732..1226313) Haemophilus influenzae PittEE 5225630 YP_001290972.1 CDS CGSHiEE_06190 NC_009566.1 1226355 1227341 D catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; para-aminobenzoate synthase component I 1226355..1227341 Haemophilus influenzae PittEE 5225631 YP_001290973.1 CDS CGSHiEE_06195 NC_009566.1 1227341 1227907 D COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; hypothetical protein 1227341..1227907 Haemophilus influenzae PittEE 5225914 YP_001290974.1 CDS CGSHiEE_06200 NC_009566.1 1227947 1228291 R COG2926 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1227947..1228291) Haemophilus influenzae PittEE 5225915 YP_001290975.1 CDS CGSHiEE_06205 NC_009566.1 1228483 1229571 D catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 1228483..1229571 Haemophilus influenzae PittEE 5225916 YP_001290976.1 CDS CGSHiEE_06220 NC_009566.1 1230836 1231159 R COG0278 Glutaredoxin-related protein; glutaredoxin-like protein complement(1230836..1231159) Haemophilus influenzae PittEE 5225917 YP_001290977.1 CDS CGSHiEE_06225 NC_009566.1 1231310 1232026 R COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; outer membrane protein P5 complement(1231310..1232026) Haemophilus influenzae PittEE 5225918 YP_001290978.1 CDS CGSHiEE_06230 NC_009566.1 1232778 1235861 D COG0277 FAD/FMN-containing dehydrogenases; hypothetical protein 1232778..1235861 Haemophilus influenzae PittEE 5225919 YP_001290979.1 CDS CGSHiEE_06235 NC_009566.1 1235875 1236291 D COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; hypothetical protein 1235875..1236291 Haemophilus influenzae PittEE 5224710 YP_001290980.1 CDS hemH NC_009566.1 1236288 1237259 D protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 1236288..1237259 Haemophilus influenzae PittEE 5224711 YP_001290981.1 CDS CGSHiEE_06245 NC_009566.1 1237339 1238196 D COG3118 Thioredoxin domain-containing protein; thioredoxin domain-containing protein 1237339..1238196 Haemophilus influenzae PittEE 5224712 YP_001290982.1 CDS hemH NC_009566.1 1238270 1239226 D COG0492 Thioredoxin reductase; ferrochelatase 1238270..1239226 Haemophilus influenzae PittEE 5224713 YP_001290983.1 CDS CGSHiEE_06255 NC_009566.1 1239298 1241058 D in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component 1239298..1241058 Haemophilus influenzae PittEE 5224714 YP_001290984.1 CDS CGSHiEE_06260 NC_009566.1 1241058 1242788 D in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component 1241058..1242788 Haemophilus influenzae PittEE 5224715 YP_001290985.1 CDS nrdG NC_009566.1 1243037 1243504 D activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein 1243037..1243504 Haemophilus influenzae PittEE 5224716 YP_001290986.1 CDS CGSHiEE_06270 NC_009566.1 1243603 1244925 R COG1823 Predicted Na+/dicarboxylate symporter; proton glutamate symport protein complement(1243603..1244925) Haemophilus influenzae PittEE 5226133 YP_001290987.1 CDS CGSHiEE_06275 NC_009566.1 1245020 1245229 R COG1280 Putative threonine efflux protein; hypothetical protein complement(1245020..1245229) Haemophilus influenzae PittEE 5226134 YP_001290988.1 CDS CGSHiEE_06280 NC_009566.1 1245231 1245770 R COG0634 Hypoxanthine-guanine phosphoribosyltransferase; hypoxanthine-guanine phosphoribosyltransferase complement(1245231..1245770) Haemophilus influenzae PittEE 5226135 YP_001290989.1 CDS nrdG NC_009566.1 1245980 1247335 R COG0312 Predicted Zn-dependent proteases and their inactivated homologs; anaerobic ribonucleotide reductase-activating protein complement(1245980..1247335) Haemophilus influenzae PittEE 5226136 YP_001290990.1 CDS CGSHiEE_06290 NC_009566.1 1247424 1247960 D COG3028 Uncharacterized protein conserved in bacteria; hypothetical protein 1247424..1247960 Haemophilus influenzae PittEE 5226137 YP_001290991.1 CDS CGSHiEE_06295 NC_009566.1 1248011 1248625 D COG3117 Uncharacterized protein conserved in bacteria; hypothetical protein 1248011..1248625 Haemophilus influenzae PittEE 5226138 YP_001290992.1 CDS CGSHiEE_06300 NC_009566.1 1248606 1249124 D COG1934 Uncharacterized protein conserved in bacteria; hypothetical protein 1248606..1249124 Haemophilus influenzae PittEE 5226139 YP_001290993.1 CDS CGSHiEE_06305 NC_009566.1 1249128 1249853 D COG1137 ABC-type (unclassified) transport system, ATPase component; ABC transporter ATP-binding protein 1249128..1249853 Haemophilus influenzae PittEE 5226258 YP_001290994.1 CDS CGSHiEE_06310 NC_009566.1 1249856 1250350 D COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); nitrogen regulatory IIA protein 1249856..1250350 Haemophilus influenzae PittEE 5226259 YP_001290995.1 CDS CGSHiEE_06315 NC_009566.1 1250368 1251315 D COG1660 Predicted P-loop-containing kinase; hypothetical protein 1250368..1251315 Haemophilus influenzae PittEE 5226260 YP_001290996.1 CDS CGSHiEE_06320 NC_009566.1 1251271 1252428 R COG1605 Chorismate mutase; chorismate mutase/prephenate dehydratase complement(1251271..1252428) Haemophilus influenzae PittEE 5226261 YP_001290997.1 CDS lpxC NC_009566.1 1252555 1253472 R zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase complement(1252555..1253472) Haemophilus influenzae PittEE 5226262 YP_001290998.1 CDS CGSHiEE_06330 NC_009566.1 1253511 1254776 R GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ complement(1253511..1254776) Haemophilus influenzae PittEE 5226263 YP_001290999.1 CDS CGSHiEE_06345 NC_009566.1 1256157 1256921 R COG1589 Cell division septal protein; cell division protein FtsZ complement(1256157..1256921) Haemophilus influenzae PittEE 5226264 YP_001291000.1 CDS ddl NC_009566.1 1256921 1257814 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase complement(1256921..1257814) Haemophilus influenzae PittEE 5225598 YP_001291001.1 CDS murC NC_009566.1 1257914 1259341 R Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase complement(1257914..1259341) Haemophilus influenzae PittEE 5225599 YP_001291002.1 CDS murG NC_009566.1 1259478 1260533 R UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase complement(1259478..1260533) Haemophilus influenzae PittEE 5225600 YP_001291003.1 CDS murG NC_009566.1 1260545 1261729 R COG0772 Bacterial cell division membrane protein; N-acetylglucosaminyl transferase complement(1260545..1261729) Haemophilus influenzae PittEE 5225601 YP_001291004.1 CDS murD NC_009566.1 1261751 1263064 R UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase complement(1261751..1263064) Haemophilus influenzae PittEE 5225602 YP_001291005.1 CDS mraY NC_009566.1 1263176 1264258 R First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase complement(1263176..1264258) Haemophilus influenzae PittEE 5225603 YP_001291006.1 CDS mraY NC_009566.1 1264252 1265625 R COG0770 UDP-N-acetylmuramyl pentapeptide synthase; phospho-N-acetylmuramoyl-pentapeptide- transferase complement(1264252..1265625) Haemophilus influenzae PittEE 5226078 YP_001291007.1 CDS murE NC_009566.1 1265639 1267105 R involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase complement(1265639..1267105) Haemophilus influenzae PittEE 5226079 YP_001291008.1 CDS CGSHiEE_06390 NC_009566.1 1267115 1268947 R COG0768 Cell division protein FtsI/penicillin-binding protein 2; peptidoglycan synthetase FtsI complement(1267115..1268947) Haemophilus influenzae PittEE 5226080 YP_001291009.1 CDS murE NC_009566.1 1268959 1269282 R COG3116 Cell division protein; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase complement(1268959..1269282) Haemophilus influenzae PittEE 5226081 YP_001291010.1 CDS mraW NC_009566.1 1269285 1270250 R COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis; S-adenosyl-methyltransferase MraW complement(1269285..1270250) Haemophilus influenzae PittEE 5226082 YP_001291011.1 CDS CGSHiEE_06405 NC_009566.1 1270281 1270736 R MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ complement(1270281..1270736) Haemophilus influenzae PittEE 5226083 YP_001291012.1 CDS CGSHiEE_06410 NC_009566.1 1270938 1272473 R COG1966 Carbon starvation protein, predicted membrane protein; carbon starvation membrane protein complement(1270938..1272473) Haemophilus influenzae PittEE 5226084 YP_001291013.1 CDS CGSHiEE_06415 NC_009566.1 1272721 1272951 D COG0777 Acetyl-CoA carboxylase beta subunit; hypothetical protein 1272721..1272951 Haemophilus influenzae PittEE 5225946 YP_001291014.1 CDS CGSHiEE_06420 NC_009566.1 1273601 1274554 R COG0176 Transaldolase; transaldolase B complement(1273601..1274554) Haemophilus influenzae PittEE 5225947 YP_001291015.1 CDS CGSHiEE_06425 NC_009566.1 1274849 1276486 D COG4166 ABC-type oligopeptide transport system, periplasmic component; transaldolase B 1274849..1276486 Haemophilus influenzae PittEE 5225948 YP_001291016.1 CDS oppB NC_009566.1 1276567 1277487 D COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; oligopeptide transporter permease 1276567..1277487 Haemophilus influenzae PittEE 5225949 YP_001291017.1 CDS oppB NC_009566.1 1277497 1278432 D COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; oligopeptide permease ABC transporter membrane protein 1277497..1278432 Haemophilus influenzae PittEE 5225950 YP_001291018.1 CDS oppD NC_009566.1 1278442 1279413 D COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component; oligopeptide transporter ATP-binding protein 1278442..1279413 Haemophilus influenzae PittEE 5225951 YP_001291019.1 CDS CGSHiEE_06445 NC_009566.1 1279410 1280408 D COG4608 ABC-type oligopeptide transport system, ATPase component; oligopeptide transport ATP-binding protein 1279410..1280408 Haemophilus influenzae PittEE 5225952 YP_001291020.1 CDS engB NC_009566.1 1281420 1282037 D binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 1281420..1282037 Haemophilus influenzae PittEE 5225953 YP_001291021.1 CDS CGSHiEE_06465 NC_009566.1 1282153 1283682 D COG0606 Predicted ATPase with chaperone activity; GTPase EngB 1282153..1283682 Haemophilus influenzae PittEE 5226234 YP_001291022.1 CDS CGSHiEE_06470 NC_009566.1 1283716 1284387 R catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase complement(1283716..1284387) Haemophilus influenzae PittEE 5226235 YP_001291023.1 CDS CGSHiEE_06475 NC_009566.1 1284498 1285001 D COG0526 Thiol-disulfide isomerase and thioredoxins; deoxyribose-phosphate aldolase 1284498..1285001 Haemophilus influenzae PittEE 5226236 YP_001291024.1 CDS rfaD NC_009566.1 1285109 1285981 D catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-mannoheptose-6-epimerase 1285109..1285981 Haemophilus influenzae PittEE 5226237 YP_001291025.1 CDS rfaD NC_009566.1 1286032 1287249 R ADP-L-glycero-D-mannoheptose-6-epimerase complement(1286032..1287249) Haemophilus influenzae PittEE 5226238 YP_001291026.1 CDS CGSHiEE_06490 NC_009566.1 1287416 1287514 R COG1070 Sugar (pentulose and hexulose) kinases; hypothetical protein complement(1287416..1287514) Haemophilus influenzae PittEE 5226239 YP_001291027.1 CDS CGSHiEE_06495 NC_009566.1 1287571 1288890 R catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase complement(1287571..1288890) Haemophilus influenzae PittEE 5225657 YP_001291028.1 CDS xylF NC_009566.1 1289124 1290122 D periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 1289124..1290122 Haemophilus influenzae PittEE 5225658 YP_001291029.1 CDS CGSHiEE_06515 NC_009566.1 1291687 1292814 D COG4214 ABC-type xylose transport system, permease component; D-xylose ABC transporter permease protein 1291687..1292814 Haemophilus influenzae PittEE 5225659 YP_001291030.1 CDS CGSHiEE_06520 NC_009566.1 1293089 1294261 D COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; putative aspartate aminotransferase 1293089..1294261 Haemophilus influenzae PittEE 5225660 YP_001291031.1 CDS CGSHiEE_06525 NC_009566.1 1294263 1295669 D COG1757 Na+/H+ antiporter; Na(+)/H(+) antiporter 1294263..1295669 Haemophilus influenzae PittEE 5225661 YP_001291032.1 CDS CGSHiEE_06530 NC_009566.1 1295781 1296944 D COG1609 Transcriptional regulators; xylose operon regulatory protein 1295781..1296944 Haemophilus influenzae PittEE 5225662 YP_001291033.1 CDS CGSHiEE_06535 NC_009566.1 1297020 1298060 D COG0859 ADP-heptose:LPS heptosyltransferase; ADP-heptose--lipooligosaccharide heptosyltransferase II 1297020..1298060 Haemophilus influenzae PittEE 5225931 YP_001291034.1 CDS CGSHiEE_06540 NC_009566.1 1298169 1299392 R COG0477 Permeases of the major facilitator superfamily; transporter protein complement(1298169..1299392) Haemophilus influenzae PittEE 5225932 YP_001291035.1 CDS CGSHiEE_06545 NC_009566.1 1299868 1300818 R COG0031 Cysteine synthase; D-xylose transporter subunit complement(1299868..1300818) Haemophilus influenzae PittEE 5225933 YP_001291036.1 CDS CGSHiEE_06550 NC_009566.1 1300918 1301736 R putative role in sulfur assimilation; putative sulfate transport protein CysZ complement(1300918..1301736) Haemophilus influenzae PittEE 5225934 YP_001291037.1 CDS CGSHiEE_06555 NC_009566.1 1301889 1302875 D interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA 1301889..1302875 Haemophilus influenzae PittEE 5225935 YP_001291038.1 CDS ligA NC_009566.1 1302987 1304999 D this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 1302987..1304999 Haemophilus influenzae PittEE 5225936 YP_001291039.1 CDS CGSHiEE_06565 NC_009566.1 1305004 1305303 R hypothetical protein complement(1305004..1305303) Haemophilus influenzae PittEE 5225937 YP_001291040.1 CDS CGSHiEE_06570 NC_009566.1 1305314 1305499 R hypothetical protein complement(1305314..1305499) Haemophilus influenzae PittEE 5225478 YP_001291041.1 CDS CGSHiEE_06575 NC_009566.1 1305560 1305841 R COG0272 NAD-dependent DNA ligase (contains BRCT domain type II); hypothetical protein complement(1305560..1305841) Haemophilus influenzae PittEE 5225479 YP_001291042.1 CDS CGSHiEE_06580 NC_009566.1 1305934 1306851 R COG4235 Cytochrome c biogenesis factor; TPR repeat-containing protein complement(1305934..1306851) Haemophilus influenzae PittEE 5225480 YP_001291043.1 CDS CGSHiEE_06585 NC_009566.1 1306852 1307292 R COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes; cytochrome C-type biogenesis protein complement(1306852..1307292) Haemophilus influenzae PittEE 5225481 YP_001291044.1 CDS CGSHiEE_06590 NC_009566.1 1307312 1307800 R COG0526 Thiol-disulfide isomerase and thioredoxins; thiol-disulfide interchange protein complement(1307312..1307800) Haemophilus influenzae PittEE 5225482 YP_001291045.1 CDS CGSHiEE_06595 NC_009566.1 1307999 1309945 R COG1138 Cytochrome c biogenesis factor; cytochrome C-type biogenesis protein complement(1307999..1309945) Haemophilus influenzae PittEE 5225483 YP_001291046.1 CDS CGSHiEE_06600 NC_009566.1 1309942 1310463 R CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE complement(1309942..1310463) Haemophilus influenzae PittEE 5225484 YP_001291047.1 CDS CGSHiEE_06605 NC_009566.1 1310460 1310663 R COG3114 Heme exporter protein D; heme exporter protein D complement(1310460..1310663) Haemophilus influenzae PittEE 5226163 YP_001291048.1 CDS CGSHiEE_06610 NC_009566.1 1310705 1311445 R COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component; heme exporter protein C complement(1310705..1311445) Haemophilus influenzae PittEE 5226164 YP_001291049.1 CDS CGSHiEE_06615 NC_009566.1 1311505 1312170 R COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component; heme exporter protein B complement(1311505..1312170) Haemophilus influenzae PittEE 5226165 YP_001291050.1 CDS CGSHiEE_06620 NC_009566.1 1312175 1312813 R ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA complement(1312175..1312813) Haemophilus influenzae PittEE 5226166 YP_001291051.1 CDS CGSHiEE_06625 NC_009566.1 1313062 1313697 D COG0605 Superoxide dismutase; superoxide dismutase (Mn) 1313062..1313697 Haemophilus influenzae PittEE 5226167 YP_001291052.1 CDS CGSHiEE_06630 NC_009566.1 1314116 1314910 D COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component; ABC transporter ATPase 1314116..1314910 Haemophilus influenzae PittEE 5226168 YP_001291053.1 CDS CGSHiEE_06635 NC_009566.1 1314907 1315692 D COG0767 ABC-type transport system involved in resistance to organic solvents, permease component; ABC transporter permease 1314907..1315692 Haemophilus influenzae PittEE 5226169 YP_001291054.1 CDS CGSHiEE_06640 NC_009566.1 1315702 1316202 D COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component; ABC transporter periplasmic protein 1315702..1316202 Haemophilus influenzae PittEE 5225586 YP_001291055.1 CDS CGSHiEE_06645 NC_009566.1 1316235 1316879 D COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component; ABC transporter 1316235..1316879 Haemophilus influenzae PittEE 5225587 YP_001291056.1 CDS CGSHiEE_06650 NC_009566.1 1316890 1317207 D COG3113 Predicted NTP binding protein (contains STAS domain); NTP binding protein, contains STAS domain 1316890..1317207 Haemophilus influenzae PittEE 5225588 YP_001291057.1 CDS ligA NC_009566.1 1317228 1317485 D COG5007 Predicted transcriptional regulator, BolA superfamily; NAD-dependent DNA ligase LigA 1317228..1317485 Haemophilus influenzae PittEE 5225589 YP_001291058.1 CDS CGSHiEE_06660 NC_009566.1 1317496 1318770 D adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1317496..1318770 Haemophilus influenzae PittEE 5225590 YP_001291059.1 CDS CGSHiEE_06665 NC_009566.1 1319071 1319844 D COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; amino-acid ABC transporter binding protein 1319071..1319844 Haemophilus influenzae PittEE 5225591 YP_001291060.1 CDS CGSHiEE_06680 NC_009566.1 1320555 1321322 D COG1126 ABC-type polar amino acid transport system, ATPase component; putative amino-acid ABC transporter ATP-binding protein 1320555..1321322 Haemophilus influenzae PittEE 5225592 YP_001291061.1 CDS CGSHiEE_06685 NC_009566.1 1321503 1322183 D COG3201 Nicotinamide mononucleotide transporter; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1321503..1322183 Haemophilus influenzae PittEE 5225846 YP_001291062.1 CDS pyrG NC_009566.1 1322325 1323962 R CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase complement(1322325..1323962) Haemophilus influenzae PittEE 5225847 YP_001291063.1 CDS CGSHiEE_06695 NC_009566.1 1323991 1324170 D COG0504 CTP synthase (UTP-ammonia lyase); hypothetical protein 1323991..1324170 Haemophilus influenzae PittEE 5225848 YP_001291064.1 CDS CGSHiEE_06700 NC_009566.1 1324615 1326180 D COG1271 Cytochrome bd-type quinol oxidase, subunit 1; cytochrome oxidase subunit I 1324615..1326180 Haemophilus influenzae PittEE 5225849 YP_001291065.1 CDS CGSHiEE_06705 NC_009566.1 1326195 1327331 D putative cytochrome oxidase subunit II 1326195..1327331 Haemophilus influenzae PittEE 5225850 YP_001291066.1 CDS CGSHiEE_06710 NC_009566.1 1327343 1327441 D COG1294 Cytochrome bd-type quinol oxidase, subunit 2; hypothetical protein 1327343..1327441 Haemophilus influenzae PittEE 5225851 YP_001291067.1 CDS CGSHiEE_06715 NC_009566.1 1327597 1328049 D COG2707 Predicted membrane protein; hypothetical protein 1327597..1328049 Haemophilus influenzae PittEE 5225852 YP_001291068.1 CDS CGSHiEE_06720 NC_009566.1 1328050 1328424 D COG2363 Uncharacterized small membrane protein; CTP synthetase 1328050..1328424 Haemophilus influenzae PittEE 5226036 YP_001291069.1 CDS CGSHiEE_06725 NC_009566.1 1328421 1332335 D involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1328421..1332335 Haemophilus influenzae PittEE 5226037 YP_001291070.1 CDS CGSHiEE_06730 NC_009566.1 1332359 1333243 D COG0466 ATP-dependent Lon protease, bacterial type; ATP-dependent RNA helicase HrpA 1332359..1333243 Haemophilus influenzae PittEE 5226038 YP_001291071.1 CDS nrfA NC_009566.1 1333973 1335499 D catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 1333973..1335499 Haemophilus influenzae PittEE 5226039 YP_001291072.1 CDS CGSHiEE_06740 NC_009566.1 1335576 1336226 D part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 1335576..1336226 Haemophilus influenzae PittEE 5226040 YP_001291073.1 CDS CGSHiEE_06745 NC_009566.1 1336223 1336900 D COG0437 Fe-S-cluster-containing hydrogenase components 1; Fe-S-cluster-containing hydrogenase subunit NrfC 1336223..1336900 Haemophilus influenzae PittEE 5226041 YP_001291074.1 CDS pyrH NC_009566.1 1338100 1338813 R Catalyzes the phosphorylation of UMP to UDP; uridylate kinase complement(1338100..1338813) Haemophilus influenzae PittEE 5226042 YP_001291075.1 CDS CGSHiEE_06765 NC_009566.1 1338945 1340504 D COG2194 Predicted membrane-associated, metal-dependent hydrolase; PE--lipooligosaccharide phosphorylethanolamine transferase 1338945..1340504 Haemophilus influenzae PittEE 5226064 YP_001291076.1 CDS fabZ NC_009566.1 1340590 1341036 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 1340590..1341036 Haemophilus influenzae PittEE 5226065 YP_001291077.1 CDS CGSHiEE_06775 NC_009566.1 1341050 1341838 D catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 1341050..1341838 Haemophilus influenzae PittEE 5226066 YP_001291078.1 CDS lpxB NC_009566.1 1341905 1343077 D catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 1341905..1343077 Haemophilus influenzae PittEE 5226067 YP_001291079.1 CDS rnhB NC_009566.1 1343070 1343663 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1343070..1343663 Haemophilus influenzae PittEE 5226068 YP_001291080.1 CDS CGSHiEE_06790 NC_009566.1 1343865 1346006 D COG2189 Adenine specific DNA methylase Mod; putative type III restriction/modification system modification methylase 1343865..1346006 Haemophilus influenzae PittEE 5226069 YP_001291081.1 CDS CGSHiEE_06805 NC_009566.1 1348884 1349225 R COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit; hypothetical protein complement(1348884..1349225) Haemophilus influenzae PittEE 5226070 YP_001291082.1 CDS CGSHiEE_06810 NC_009566.1 1349337 1350233 D COG2207 AraC-type DNA-binding domain-containing proteins; transcriptional regulator AraC family protein 1349337..1350233 Haemophilus influenzae PittEE 5225989 YP_001291083.1 CDS CGSHiEE_06815 NC_009566.1 1350312 1352156 D COG1132 ABC-type multidrug transport system, ATPase and permease components; ABC transporter ATP-binding protein 1350312..1352156 Haemophilus influenzae PittEE 5225990 YP_001291084.1 CDS CGSHiEE_06820 NC_009566.1 1352281 1352559 R hypothetical protein complement(1352281..1352559) Haemophilus influenzae PittEE 5225991 YP_001291085.1 CDS CGSHiEE_06825 NC_009566.1 1352568 1352930 R COG2608 Copper chaperone; hypothetical protein complement(1352568..1352930) Haemophilus influenzae PittEE 5225992 YP_001291086.1 CDS CGSHiEE_06830 NC_009566.1 1352905 1354014 R COG1305 Transglutaminase-like enzymes, putative cysteine proteases; hypothetical protein complement(1352905..1354014) Haemophilus influenzae PittEE 5225993 YP_001291087.1 CDS CGSHiEE_06835 NC_009566.1 1354268 1356562 D COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; anaerobic dimethyl sulfoxide reductase chain A 1354268..1356562 Haemophilus influenzae PittEE 5225994 YP_001291088.1 CDS CGSHiEE_06850 NC_009566.1 1357317 1358156 D COG3302 DMSO reductase anchor subunit; anaerobic dimethyl sulfoxide reductase chain C 1357317..1358156 Haemophilus influenzae PittEE 5225995 YP_001291089.1 CDS CGSHiEE_06855 NC_009566.1 1358268 1358879 D binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1358268..1358879 Haemophilus influenzae PittEE 5225731 YP_001291090.1 CDS CGSHiEE_06860 NC_009566.1 1358879 1359379 D ferredoxin 1358879..1359379 Haemophilus influenzae PittEE 5225732 YP_001291091.1 CDS CGSHiEE_06865 NC_009566.1 1359737 1360291 R UDP-N-acetylglucosamine acyltransferase complement(1359737..1360291) Haemophilus influenzae PittEE 5225733 YP_001291092.1 CDS CGSHiEE_06870 NC_009566.1 1360516 1360983 D hypothetical protein 1360516..1360983 Haemophilus influenzae PittEE 5225734 YP_001291093.1 CDS CGSHiEE_06875 NC_009566.1 1361167 1362003 D hypothetical protein 1361167..1362003 Haemophilus influenzae PittEE 5225735 YP_001291094.1 CDS CGSHiEE_06880 NC_009566.1 1362184 1362729 R hypothetical protein complement(1362184..1362729) Haemophilus influenzae PittEE 5225736 YP_001291095.1 CDS CGSHiEE_06885 NC_009566.1 1362729 1363676 R responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA complement(1362729..1363676) Haemophilus influenzae PittEE 5225737 YP_001291096.1 CDS CGSHiEE_06890 NC_009566.1 1363972 1364463 R putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; putative nucleotide-binding protein complement(1363972..1364463) Haemophilus influenzae PittEE 5225738 YP_001291097.1 CDS serB NC_009566.1 1364481 1365425 R catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase complement(1364481..1365425) Haemophilus influenzae PittEE 5226120 YP_001291098.1 CDS CGSHiEE_06900 NC_009566.1 1365806 1367803 D catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1365806..1367803 Haemophilus influenzae PittEE 5226121 YP_001291099.1 CDS CGSHiEE_06905 NC_009566.1 1367928 1368929 R COG0502 Biotin synthase and related enzymes; biotin synthase complement(1367928..1368929) Haemophilus influenzae PittEE 5226122 YP_001291100.1 CDS thiP NC_009566.1 1369672 1371288 R permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein complement(1369672..1371288) Haemophilus influenzae PittEE 5226123 YP_001291101.1 CDS CGSHiEE_06925 NC_009566.1 1371293 1372291 R COG4143 ABC-type thiamine transport system, periplasmic component; thiamin ABC transporter periplasmic-binding protein complement(1371293..1372291) Haemophilus influenzae PittEE 5226124 YP_001291102.1 CDS thiP NC_009566.1 1372538 1372885 R COG1555 DNA uptake protein and related DNA-binding proteins; hypothetical protein complement(1372538..1372885) Haemophilus influenzae PittEE 5226125 YP_001291103.1 CDS ispH NC_009566.1 1373054 1373998 R catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase complement(1373054..1373998) Haemophilus influenzae PittEE 5224704 YP_001291104.1 CDS lspA NC_009566.1 1376227 1378095 R COG0760 Parvulin-like peptidyl-prolyl isomerase; lipoprotein signal peptidase complement(1376227..1378095) Haemophilus influenzae PittEE 5224705 YP_001291105.1 CDS trmE NC_009566.1 1378285 1379643 R in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE complement(1378285..1379643) Haemophilus influenzae PittEE 5224706 YP_001291106.1 CDS CGSHiEE_06970 NC_009566.1 1380079 1381704 R functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; putative inner membrane protein translocase component YidC complement(1380079..1381704) Haemophilus influenzae PittEE 5224707 YP_001291107.1 CDS rnpA NC_009566.1 1381704 1382288 R COG0594 RNase P protein component; ribonuclease P complement(1381704..1382288) Haemophilus influenzae PittEE 5224708 YP_001291108.1 CDS rpmH NC_009566.1 1382308 1382442 R in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 complement(1382308..1382442) Haemophilus influenzae PittEE 5224709 YP_001291109.1 CDS CGSHiEE_06985 NC_009566.1 1382623 1384068 R hypothetical protein complement(1382623..1384068) Haemophilus influenzae PittEE 5226071 YP_001291110.1 CDS CGSHiEE_06990 NC_009566.1 1384166 1386091 D COG0457 FOG: TPR repeat; transferrin-binding protein 2 1384166..1386091 Haemophilus influenzae PittEE 5226072 YP_001291111.1 CDS rpmH NC_009566.1 1386133 1388880 D COG1629 Outer membrane receptor proteins, mostly Fe transport; 50S ribosomal protein L34 1386133..1388880 Haemophilus influenzae PittEE 5226073 YP_001291112.1 CDS dnaA NC_009566.1 1389072 1390436 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1389072..1390436 Haemophilus influenzae PittEE 5226074 YP_001291113.1 CDS CGSHiEE_07005 NC_009566.1 1390449 1391549 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 1390449..1391549 Haemophilus influenzae PittEE 5226075 YP_001291114.1 CDS recF NC_009566.1 1391524 1392606 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 1391524..1392606 Haemophilus influenzae PittEE 5226076 YP_001291115.1 CDS recF NC_009566.1 1392872 1398148 D COG3468 Type V secretory pathway, adhesin AidA; recombination protein F 1392872..1398148 Haemophilus influenzae PittEE 5226077 YP_001291116.1 CDS leuD NC_009566.1 1398262 1398864 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(1398262..1398864) Haemophilus influenzae PittEE 5226098 YP_001291117.1 CDS CGSHiEE_07025 NC_009566.1 1398889 1400298 R dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit complement(1398889..1400298) Haemophilus influenzae PittEE 5226099 YP_001291118.1 CDS CGSHiEE_07030 NC_009566.1 1400473 1401549 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(1400473..1401549) Haemophilus influenzae PittEE 5226100 YP_001291119.1 CDS CGSHiEE_07035 NC_009566.1 1401630 1403177 R catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase complement(1401630..1403177) Haemophilus influenzae PittEE 5226101 YP_001291120.1 CDS CGSHiEE_07040 NC_009566.1 1403746 1404867 D COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake; 2-isopropylmalate synthase 1403746..1404867 Haemophilus influenzae PittEE 5226102 YP_001291121.1 CDS CGSHiEE_07045 NC_009566.1 1404920 1405696 D hypothetical protein 1404920..1405696 Haemophilus influenzae PittEE 5226103 YP_001291122.1 CDS CGSHiEE_07050 NC_009566.1 1405689 1406270 D COG3022 Uncharacterized protein conserved in bacteria; hypothetical protein 1405689..1406270 Haemophilus influenzae PittEE 5226104 YP_001291123.1 CDS CGSHiEE_07055 NC_009566.1 1406366 1407331 D catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 1406366..1407331 Haemophilus influenzae PittEE 5226105 YP_001291124.1 CDS smpB NC_009566.1 1407575 1408060 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 1407575..1408060 Haemophilus influenzae PittEE 5225818 YP_001291125.1 CDS fis NC_009566.1 1408155 1408454 R Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis complement(1408155..1408454) Haemophilus influenzae PittEE 5225819 YP_001291126.1 CDS fis NC_009566.1 1408448 1409509 R COG0042 tRNA-dihydrouridine synthase; DNA-binding protein Fis complement(1408448..1409509) Haemophilus influenzae PittEE 5225820 YP_001291127.1 CDS prmA NC_009566.1 1409575 1410462 R methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase complement(1409575..1410462) Haemophilus influenzae PittEE 5225821 YP_001291128.1 CDS CGSHiEE_07080 NC_009566.1 1410503 1411048 R COG2184 Protein involved in cell division; cell filamentation protein complement(1410503..1411048) Haemophilus influenzae PittEE 5225822 YP_001291129.1 CDS prmA NC_009566.1 1411081 1411953 R COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; ribosomal protein L11 methyltransferase complement(1411081..1411953) Haemophilus influenzae PittEE 5225823 YP_001291130.1 CDS panF NC_009566.1 1412073 1413527 R mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter complement(1412073..1413527) Haemophilus influenzae PittEE 5225824 YP_001291131.1 CDS panF NC_009566.1 1413524 1413781 R COG3924 Predicted membrane protein; sodium/panthothenate symporter complement(1413524..1413781) Haemophilus influenzae PittEE 5225825 YP_001291132.1 CDS CGSHiEE_07100 NC_009566.1 1413986 1415332 R an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit complement(1413986..1415332) Haemophilus influenzae PittEE 5226220 YP_001291133.1 CDS CGSHiEE_07105 NC_009566.1 1415509 1415976 R composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit complement(1415509..1415976) Haemophilus influenzae PittEE 5226221 YP_001291134.1 CDS CGSHiEE_07110 NC_009566.1 1416130 1416579 R catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase complement(1416130..1416579) Haemophilus influenzae PittEE 5226222 YP_001291135.1 CDS CGSHiEE_07115 NC_009566.1 1416636 1417625 R catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase complement(1416636..1417625) Haemophilus influenzae PittEE 5226223 YP_001291136.1 CDS CGSHiEE_07120 NC_009566.1 1417694 1418551 R catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase complement(1417694..1418551) Haemophilus influenzae PittEE 5226224 YP_001291137.1 CDS CGSHiEE_07125 NC_009566.1 1418697 1419263 D COG0447 Dihydroxynaphthoic acid synthase; hypothetical protein 1418697..1419263 Haemophilus influenzae PittEE 5226225 YP_001291138.1 CDS rpsT NC_009566.1 1419336 1419599 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(1419336..1419599) Haemophilus influenzae PittEE 5226226 YP_001291139.1 CDS CGSHiEE_07145 NC_009566.1 1421488 1422414 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1421488..1422414 Haemophilus influenzae PittEE 5226050 YP_001291140.1 CDS ileS NC_009566.1 1422443 1425268 D IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 1422443..1425268 Haemophilus influenzae PittEE 5226051 YP_001291141.1 CDS CGSHiEE_07155 NC_009566.1 1425388 1425738 D COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases; HIT-like protein 1425388..1425738 Haemophilus influenzae PittEE 5226052 YP_001291142.1 CDS ileS NC_009566.1 1425738 1426088 D COG5633 Predicted periplasmic lipoprotein; isoleucyl-tRNA synthetase 1425738..1426088 Haemophilus influenzae PittEE 5226053 YP_001291143.1 CDS CGSHiEE_07165 NC_009566.1 1426092 1427144 D hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1426092..1427144 Haemophilus influenzae PittEE 5226054 YP_001291144.1 CDS rumB NC_009566.1 1427141 1428319 D RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 1427141..1428319 Haemophilus influenzae PittEE 5226055 YP_001291145.1 CDS CGSHiEE_07175 NC_009566.1 1428684 1429358 R complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein complement(1428684..1429358) Haemophilus influenzae PittEE 5226056 YP_001291146.1 CDS CGSHiEE_07180 NC_009566.1 1429343 1429594 R COG3089 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1429343..1429594) Haemophilus influenzae PittEE 5226265 YP_001291147.1 CDS slmA NC_009566.1 1429616 1430272 R FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein complement(1429616..1430272) Haemophilus influenzae PittEE 5226266 YP_001291148.1 CDS dut NC_009566.1 1430276 1430731 R catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase complement(1430276..1430731) Haemophilus influenzae PittEE 5226267 YP_001291149.1 CDS CGSHiEE_07195 NC_009566.1 1430779 1431981 R catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase complement(1430779..1431981) Haemophilus influenzae PittEE 5226268 YP_001291150.1 CDS radC NC_009566.1 1432166 1432810 D Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 1432166..1432810 Haemophilus influenzae PittEE 5226269 YP_001291151.1 CDS rpmB NC_009566.1 1433023 1433259 D required for 70S ribosome assembly; 50S ribosomal protein L28 1433023..1433259 Haemophilus influenzae PittEE 5226270 YP_001291152.1 CDS rpmG NC_009566.1 1433271 1433441 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 1433271..1433441 Haemophilus influenzae PittEE 5226271 YP_001291153.1 CDS CGSHiEE_07215 NC_009566.1 1433787 1435151 D catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde; diaminobutyrate--2-oxoglutarate aminotransferase 1433787..1435151 Haemophilus influenzae PittEE 5226272 YP_001291154.1 CDS CGSHiEE_07220 NC_009566.1 1435298 1435531 D COG4456 Virulence-associated protein and related proteins; hypothetical protein 1435298..1435531 Haemophilus influenzae PittEE 5225764 YP_001291155.1 CDS CGSHiEE_07225 NC_009566.1 1435531 1435929 D COG1487 Predicted nucleic acid-binding protein, contains PIN domain; nucleic acid-binding protein 1435531..1435929 Haemophilus influenzae PittEE 5225765 YP_001291156.1 CDS CGSHiEE_07230 NC_009566.1 1435949 1437484 D COG0076 Glutamate decarboxylase and related PLP-dependent proteins; diaminobutyrate--2-oxoglutarate aminotransferase 1435949..1437484 Haemophilus influenzae PittEE 5225766 YP_001291157.1 CDS CGSHiEE_07235 NC_009566.1 1437715 1438530 D Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 1437715..1438530 Haemophilus influenzae PittEE 5225767 YP_001291158.1 CDS CGSHiEE_07240 NC_009566.1 1438604 1439626 R COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; protease DegS complement(1438604..1439626) Haemophilus influenzae PittEE 5225768 YP_001291159.1 CDS CGSHiEE_07245 NC_009566.1 1439627 1440745 R COG0117 Pyrimidine deaminase; formamidopyrimidine-DNA glycosylase complement(1439627..1440745) Haemophilus influenzae PittEE 5225769 YP_001291160.1 CDS nrdR NC_009566.1 1440748 1441197 R COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains; transcriptional regulator NrdR complement(1440748..1441197) Haemophilus influenzae PittEE 5225770 YP_001291161.1 CDS CGSHiEE_07255 NC_009566.1 1441252 1444617 R exodeoxyribonuclease V subunit gamma complement(1441252..1444617) Haemophilus influenzae PittEE 5225771 YP_001291162.1 CDS CGSHiEE_07260 NC_009566.1 1444663 1444950 R hypothetical protein complement(1444663..1444950) Haemophilus influenzae PittEE 5225739 YP_001291163.1 CDS CGSHiEE_07265 NC_009566.1 1444943 1445626 R COG1330 Exonuclease V gamma subunit; hypothetical protein complement(1444943..1445626) Haemophilus influenzae PittEE 5225740 YP_001291164.1 CDS CGSHiEE_07270 NC_009566.1 1445641 1446357 R COG4795 Type II secretory pathway, component PulJ; hypothetical protein complement(1445641..1446357) Haemophilus influenzae PittEE 5225741 YP_001291165.1 CDS CGSHiEE_07275 NC_009566.1 1446357 1446869 R COG2165 Type II secretory pathway, pseudopilin PulG; hypothetical protein complement(1446357..1446869) Haemophilus influenzae PittEE 5225742 YP_001291166.1 CDS CGSHiEE_07280 NC_009566.1 1447069 1447872 D COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family; extragenic suppressor 1447069..1447872 Haemophilus influenzae PittEE 5225743 YP_001291167.1 CDS CGSHiEE_07285 NC_009566.1 1447981 1449888 D COG1138 Cytochrome c biogenesis factor; cytochrome c-type biogenesis protein NrfE 1447981..1449888 Haemophilus influenzae PittEE 5225744 YP_001291168.1 CDS CGSHiEE_07290 NC_009566.1 1449888 1450418 D COG0526 Thiol-disulfide isomerase and thioredoxins; thiol-disulfide interchange protein 1449888..1450418 Haemophilus influenzae PittEE 5225745 YP_001291169.1 CDS CGSHiEE_07295 NC_009566.1 1450415 1451569 D COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes; cytochrome C-type biogenesis protein 1450415..1451569 Haemophilus influenzae PittEE 5225746 YP_001291170.1 CDS eno NC_009566.1 1452891 1454201 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1452891..1454201 Haemophilus influenzae PittEE 5225723 YP_001291171.1 CDS CGSHiEE_07325 NC_009566.1 1454715 1455296 D COG3210 Large exoproteins involved in heme utilization or adhesion; hypothetical protein 1454715..1455296 Haemophilus influenzae PittEE 5225724 YP_001291172.1 CDS CGSHiEE_07330 NC_009566.1 1455297 1456478 D COG0754 Glutathionylspermidine synthase; hypothetical protein 1455297..1456478 Haemophilus influenzae PittEE 5225725 YP_001291173.1 CDS eno NC_009566.1 1456711 1458237 R COG0753 Catalase; phosphopyruvate hydratase complement(1456711..1458237) Haemophilus influenzae PittEE 5225726 YP_001291174.1 CDS glyQ NC_009566.1 1458504 1459412 D glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 1458504..1459412 Haemophilus influenzae PittEE 5225727 YP_001291175.1 CDS CGSHiEE_07345 NC_009566.1 1459471 1459731 D COG4545 Glutaredoxin-related protein; glutaredoxin-like protein 1459471..1459731 Haemophilus influenzae PittEE 5225728 YP_001291176.1 CDS glyQ NC_009566.1 1459761 1460126 D COG2852 Uncharacterized protein conserved in bacteria; glycyl-tRNA synthetase subunit alpha 1459761..1460126 Haemophilus influenzae PittEE 5225729 YP_001291177.1 CDS glyS NC_009566.1 1460464 1462530 D glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 1460464..1462530 Haemophilus influenzae PittEE 5225730 YP_001291178.1 CDS CGSHiEE_07360 NC_009566.1 1462892 1463431 D putative prophage integrase 1462892..1463431 Haemophilus influenzae PittEE 5225644 YP_001291179.1 CDS CGSHiEE_07365 NC_009566.1 1463461 1463769 D major phage capsid protein 1463461..1463769 Haemophilus influenzae PittEE 5225645 YP_001291180.1 CDS CGSHiEE_07370 NC_009566.1 1463769 1463993 D COG0582 Integrase; hypothetical protein 1463769..1463993 Haemophilus influenzae PittEE 5225646 YP_001291181.1 CDS CGSHiEE_07375 NC_009566.1 1464291 1464545 D COG2161 Antitoxin of toxin-antitoxin stability system; hypothetical protein 1464291..1464545 Haemophilus influenzae PittEE 5225647 YP_001291182.1 CDS glyS NC_009566.1 1464535 1464825 D glycyl-tRNA synthetase subunit beta 1464535..1464825 Haemophilus influenzae PittEE 5225648 YP_001291183.1 CDS CGSHiEE_07385 NC_009566.1 1465082 1465237 D hypothetical protein 1465082..1465237 Haemophilus influenzae PittEE 5225649 YP_001291184.1 CDS CGSHiEE_07390 NC_009566.1 1465285 1465422 D hypothetical protein 1465285..1465422 Haemophilus influenzae PittEE 5225650 YP_001291185.1 CDS CGSHiEE_07395 NC_009566.1 1465604 1465894 R COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system; hypothetical protein complement(1465604..1465894) Haemophilus influenzae PittEE 5225651 YP_001291186.1 CDS holA NC_009566.1 1466072 1467106 R required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta complement(1466072..1467106) Haemophilus influenzae PittEE 5226194 YP_001291187.1 CDS holA NC_009566.1 1467106 1467609 R COG2980 Rare lipoprotein B; DNA polymerase III subunit delta complement(1467106..1467609) Haemophilus influenzae PittEE 5226195 YP_001291188.1 CDS leuS NC_009566.1 1467704 1470289 R leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase complement(1467704..1470289) Haemophilus influenzae PittEE 5226196 YP_001291189.1 CDS CGSHiEE_07415 NC_009566.1 1470539 1471258 D COG0020 Undecaprenyl pyrophosphate synthase; hypothetical protein 1470539..1471258 Haemophilus influenzae PittEE 5226197 YP_001291190.1 CDS CGSHiEE_07420 NC_009566.1 1471276 1472142 D COG0575 CDP-diglyceride synthetase; CDP-diglyceride synthetase 1471276..1472142 Haemophilus influenzae PittEE 5226198 YP_001291191.1 CDS CGSHiEE_07425 NC_009566.1 1472152 1473483 D COG0750 Predicted membrane-associated Zn-dependent proteases 1; hypothetical protein 1472152..1473483 Haemophilus influenzae PittEE 5226199 YP_001291192.1 CDS CGSHiEE_07430 NC_009566.1 1473503 1475908 D COG4775 Outer membrane protein/protective antigen OMA87; protective surface antigen D15 1473503..1475908 Haemophilus influenzae PittEE 5226200 YP_001291193.1 CDS leuS NC_009566.1 1476019 1476612 D COG2825 Outer membrane protein; leucyl-tRNA synthetase 1476019..1476612 Haemophilus influenzae PittEE 5226201 YP_001291194.1 CDS lpxD NC_009566.1 1476625 1477650 D adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 1476625..1477650 Haemophilus influenzae PittEE 5225447 YP_001291195.1 CDS tsf NC_009566.1 1477817 1478668 R EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts complement(1477817..1478668) Haemophilus influenzae PittEE 5225448 YP_001291196.1 CDS rpsB NC_009566.1 1478802 1479524 R one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 complement(1478802..1479524) Haemophilus influenzae PittEE 5225449 YP_001291197.1 CDS CGSHiEE_07455 NC_009566.1 1479702 1480466 R COG0500 SAM-dependent methyltransferases; hypothetical protein complement(1479702..1480466) Haemophilus influenzae PittEE 5225450 YP_001291198.1 CDS rpsB NC_009566.1 1480586 1482442 R 30S ribosomal protein S2 complement(1480586..1482442) Haemophilus influenzae PittEE 5225451 YP_001291199.1 CDS CGSHiEE_07465 NC_009566.1 1482724 1482927 D COG0475 Kef-type K+ transport systems, membrane components; hypothetical protein 1482724..1482927 Haemophilus influenzae PittEE 5225452 YP_001291200.1 CDS CGSHiEE_07470 NC_009566.1 1483025 1485730 R functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA complement(1483025..1485730) Haemophilus influenzae PittEE 5225453 YP_001291201.1 CDS CGSHiEE_07475 NC_009566.1 1485855 1486157 R COG0653 Preprotein translocase subunit SecA (ATPase, RNA helicase); hypothetical protein complement(1485855..1486157) Haemophilus influenzae PittEE 5226187 YP_001291202.1 CDS CGSHiEE_07480 NC_009566.1 1486237 1486551 D COG4701 Uncharacterized protein conserved in bacteria; hypothetical protein 1486237..1486551 Haemophilus influenzae PittEE 5226188 YP_001291203.1 CDS secA NC_009566.1 1486614 1487099 R COG0590 Cytosine/adenosine deaminases; preprotein translocase subunit SecA complement(1486614..1487099) Haemophilus influenzae PittEE 5226189 YP_001291204.1 CDS thyA NC_009566.1 1487099 1487950 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(1487099..1487950) Haemophilus influenzae PittEE 5226190 YP_001291205.1 CDS CGSHiEE_07495 NC_009566.1 1487960 1488766 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(1487960..1488766) Haemophilus influenzae PittEE 5226191 YP_001291206.1 CDS thyA NC_009566.1 1488775 1489569 R COG0730 Predicted permeases; hypothetical protein complement(1488775..1489569) Haemophilus influenzae PittEE 5226192 YP_001291207.1 CDS CGSHiEE_07505 NC_009566.1 1489569 1490159 R hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase complement(1489569..1490159) Haemophilus influenzae PittEE 5226193 YP_001291208.1 CDS CGSHiEE_07510 NC_009566.1 1490240 1491346 R catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase complement(1490240..1491346) Haemophilus influenzae PittEE 5225697 YP_001291209.1 CDS CGSHiEE_07515 NC_009566.1 1491447 1491929 D COG0262 Dihydrofolate reductase; dihydrofolate reductase 1491447..1491929 Haemophilus influenzae PittEE 5225698 YP_001291210.1 CDS CGSHiEE_07520 NC_009566.1 1492102 1493274 D COG1566 Multidrug resistance efflux pump; multidrug resistance protein A 1492102..1493274 Haemophilus influenzae PittEE 5225699 YP_001291211.1 CDS CGSHiEE_07535 NC_009566.1 1494830 1495600 R COG3087 Cell division protein; cell division protein complement(1494830..1495600) Haemophilus influenzae PittEE 5225700 YP_001291212.1 CDS CGSHiEE_07540 NC_009566.1 1495834 1498914 R COG0841 Cation/multidrug efflux pump; cation/multidrug efflux pump complement(1495834..1498914) Haemophilus influenzae PittEE 5225701 YP_001291213.1 CDS CGSHiEE_07545 NC_009566.1 1498932 1500128 R COG0845 Membrane-fusion protein; putative membrane-fusion protein complement(1498932..1500128) Haemophilus influenzae PittEE 5225702 YP_001291215.1 CDS CGSHiEE_07565 NC_009566.1 1500965 1502212 R enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB complement(1500965..1502212) Haemophilus influenzae PittEE 5225962 YP_001291216.1 CDS CGSHiEE_07570 NC_009566.1 1502329 1502535 R COG3024 Uncharacterized protein conserved in bacteria; zinc-binding protein complement(1502329..1502535) Haemophilus influenzae PittEE 5225963 YP_001291217.1 CDS coaE NC_009566.1 1502528 1503148 R catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase complement(1502528..1503148) Haemophilus influenzae PittEE 5225964 YP_001291218.1 CDS glyA NC_009566.1 1503219 1504484 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(1503219..1504484) Haemophilus influenzae PittEE 5225965 YP_001291219.1 CDS glyA NC_009566.1 1504619 1505551 R COG0463 Glycosyltransferases involved in cell wall biogenesis; serine hydroxymethyltransferase complement(1504619..1505551) Haemophilus influenzae PittEE 5225966 YP_001291220.1 CDS CGSHiEE_07590 NC_009566.1 1505538 1506824 R catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase complement(1505538..1506824) Haemophilus influenzae PittEE 5225967 YP_001291221.1 CDS purH NC_009566.1 1507010 1508608 R involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase complement(1507010..1508608) Haemophilus influenzae PittEE 5225968 YP_001291222.1 CDS purH NC_009566.1 1508797 1509201 R COG2259 Predicted membrane protein; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase complement(1508797..1509201) Haemophilus influenzae PittEE 5226085 YP_001291223.1 CDS dipZ NC_009566.1 1509318 1511057 R two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein complement(1509318..1511057) Haemophilus influenzae PittEE 5226086 YP_001291224.1 CDS CGSHiEE_07610 NC_009566.1 1511249 1511959 D COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; two-component response regulator 1511249..1511959 Haemophilus influenzae PittEE 5226087 YP_001291225.1 CDS CGSHiEE_07615 NC_009566.1 1512359 1513729 D COG1115 Na+/alanine symporter; putative Na+/alanine symporter 1512359..1513729 Haemophilus influenzae PittEE 5226088 YP_001291226.1 CDS CGSHiEE_07620 NC_009566.1 1513788 1514525 R COG1636 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1513788..1514525) Haemophilus influenzae PittEE 5226089 YP_001291227.1 CDS CGSHiEE_07625 NC_009566.1 1514576 1515547 R COG0142 Geranylgeranyl pyrophosphate synthase; octaprenyl-diphosphate synthase complement(1514576..1515547) Haemophilus influenzae PittEE 5226090 YP_001291228.1 CDS rplU NC_009566.1 1515778 1516089 D COG0261 Ribosomal protein L21; 50S ribosomal protein L21 1515778..1516089 Haemophilus influenzae PittEE 5226091 YP_001291229.1 CDS rpmA NC_009566.1 1516110 1516367 D involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1516110..1516367 Haemophilus influenzae PittEE 5226092 YP_001291230.1 CDS rpmA NC_009566.1 1516448 1517344 D COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; 50S ribosomal protein L27 1516448..1517344 Haemophilus influenzae PittEE 5225470 YP_001291231.1 CDS obgE NC_009566.1 1517397 1518608 D essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1517397..1518608 Haemophilus influenzae PittEE 5225471 YP_001291232.1 CDS ndk NC_009566.1 1518678 1519100 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(1518678..1519100) Haemophilus influenzae PittEE 5225472 YP_001291233.1 CDS CGSHiEE_07655 NC_009566.1 1519110 1520414 R catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase B complement(1519110..1520414) Haemophilus influenzae PittEE 5225473 YP_001291234.1 CDS CGSHiEE_07660 NC_009566.1 1520557 1521783 D COG3307 Lipid A core - O-antigen ligase and related enzymes; hypothetical protein 1520557..1521783 Haemophilus influenzae PittEE 5225474 YP_001291235.1 CDS CGSHiEE_07665 NC_009566.1 1521819 1522823 R COG1088 dTDP-D-glucose 4,6-dehydratase; dTDP-glucose 46-dehydratase complement(1521819..1522823) Haemophilus influenzae PittEE 5225475 YP_001291236.1 CDS CGSHiEE_07670 NC_009566.1 1522895 1524313 R undecaprenyl-phosphate galactosephosphotransferase complement(1522895..1524313) Haemophilus influenzae PittEE 5225476 YP_001291237.1 CDS CGSHiEE_07675 NC_009566.1 1524306 1525184 R COG2148 Sugar transferases involved in lipopolysaccharide synthesis; N-acetylneuraminic acid synthase-like protein complement(1524306..1525184) Haemophilus influenzae PittEE 5225477 YP_001291238.1 CDS CGSHiEE_07680 NC_009566.1 1525326 1526159 R putative polysaccharide polymerase complement(1525326..1526159) Haemophilus influenzae PittEE 5225875 YP_001291239.1 CDS CGSHiEE_07685 NC_009566.1 1526198 1526338 R COG3307 Lipid A core - O-antigen ligase and related enzymes; hypothetical protein complement(1526198..1526338) Haemophilus influenzae PittEE 5225876 YP_001291240.1 CDS CGSHiEE_07690 NC_009566.1 1526338 1527222 R COG1216 Predicted glycosyltransferases; hypothetical protein complement(1526338..1527222) Haemophilus influenzae PittEE 5225877 YP_001291241.1 CDS CGSHiEE_07695 NC_009566.1 1527227 1527979 R COG0463 Glycosyltransferases involved in cell wall biogenesis; hypothetical protein complement(1527227..1527979) Haemophilus influenzae PittEE 5225878 YP_001291242.1 CDS CGSHiEE_07700 NC_009566.1 1527960 1529177 R COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; lipopolysaccharide biosynthesis protein complement(1527960..1529177) Haemophilus influenzae PittEE 5225879 YP_001291243.1 CDS CGSHiEE_07715 NC_009566.1 1532072 1533028 D COG0174 Glutamine synthetase; CMP-neu5Ac--lipooligosaccharide alpha 2-3 sialyltransferase 1532072..1533028 Haemophilus influenzae PittEE 5225880 YP_001291244.1 CDS CGSHiEE_07720 NC_009566.1 1533160 1535010 D COG1217 Predicted membrane GTPase involved in stress response; aminopeptidase B 1533160..1535010 Haemophilus influenzae PittEE 5225881 YP_001291245.1 CDS CGSHiEE_07725 NC_009566.1 1535098 1535730 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase complement(1535098..1535730) Haemophilus influenzae PittEE 5225938 YP_001291246.1 CDS CGSHiEE_07730 NC_009566.1 1535923 1536630 D COG1738 Uncharacterized conserved protein; hypothetical protein 1535923..1536630 Haemophilus influenzae PittEE 5225939 YP_001291247.1 CDS CGSHiEE_07735 NC_009566.1 1536822 1539170 D COG0557 Exoribonuclease R; hypothetical protein 1536822..1539170 Haemophilus influenzae PittEE 5225940 YP_001291248.1 CDS CGSHiEE_07740 NC_009566.1 1539226 1539966 D Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 1539226..1539966 Haemophilus influenzae PittEE 5225941 YP_001291249.1 CDS CGSHiEE_07745 NC_009566.1 1540004 1542574 R COG0542 ATPases with chaperone activity, ATP-binding subunit; ATP-dependent chaperone ClpB complement(1540004..1542574) Haemophilus influenzae PittEE 5225942 YP_001291250.1 CDS CGSHiEE_07750 NC_009566.1 1542702 1543265 R COG0212 5-formyltetrahydrofolate cyclo-ligase; 5-formyltetrahydrofolate cyclo-ligase complement(1542702..1543265) Haemophilus influenzae PittEE 5225943 YP_001291251.1 CDS CGSHiEE_07755 NC_009566.1 1543583 1543885 R COG3027 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1543583..1543885) Haemophilus influenzae PittEE 5225944 YP_001291252.1 CDS CGSHiEE_07760 NC_009566.1 1544034 1546826 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 1544034..1546826 Haemophilus influenzae PittEE 5225945 YP_001291253.1 CDS CGSHiEE_07765 NC_009566.1 1546841 1547047 D COG3681 Uncharacterized conserved protein; hypothetical protein 1546841..1547047 Haemophilus influenzae PittEE 5225533 YP_001291254.1 CDS CGSHiEE_07770 NC_009566.1 1547179 1547940 R COG0748 Putative heme iron utilization protein; putative heme iron utilization protein complement(1547179..1547940) Haemophilus influenzae PittEE 5225534 YP_001291255.1 CDS CGSHiEE_07775 NC_009566.1 1548116 1549759 R COG0747 ABC-type dipeptide transport system, periplasmic component; heme-binding lipoprotein complement(1548116..1549759) Haemophilus influenzae PittEE 5225535 YP_001291256.1 CDS CGSHiEE_07790 NC_009566.1 1551290 1551805 R molybdopterin-guanine dinucleotide biosynthesis protein B complement(1551290..1551805) Haemophilus influenzae PittEE 5225536 YP_001291258.1 CDS CGSHiEE_07800 NC_009566.1 1552230 1552664 R COG3086 Positive regulator of sigma E activity; positive regulator of sigma E complement(1552230..1552664) Haemophilus influenzae PittEE 5225538 YP_001291259.1 CDS CGSHiEE_07805 NC_009566.1 1552658 1553431 R COG0500 SAM-dependent methyltransferases; DNA polymerase I complement(1552658..1553431) Haemophilus influenzae PittEE 5225539 YP_001291260.1 CDS CGSHiEE_07810 NC_009566.1 1553413 1554504 R catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase complement(1553413..1554504) Haemophilus influenzae PittEE 5226005 YP_001291261.1 CDS CGSHiEE_07815 NC_009566.1 1554648 1554983 R COG3085 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1554648..1554983) Haemophilus influenzae PittEE 5226006 YP_001291262.1 CDS CGSHiEE_07820 NC_009566.1 1555045 1555662 R COG0526 Thiol-disulfide isomerase and thioredoxins; thiol:disulfide interchange protein DsbA complement(1555045..1555662) Haemophilus influenzae PittEE 5226007 YP_001291263.1 CDS CGSHiEE_07825 NC_009566.1 1555673 1555939 R COG3084 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1555673..1555939) Haemophilus influenzae PittEE 5226008 YP_001291264.1 CDS mobA NC_009566.1 1556060 1556587 D in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA 1556060..1556587 Haemophilus influenzae PittEE 5226009 YP_001291265.1 CDS CGSHiEE_07835 NC_009566.1 1556725 1557717 R COG0402 Cytosine deaminase and related metal-dependent hydrolases; hypothetical protein complement(1556725..1557717) Haemophilus influenzae PittEE 5226010 YP_001291266.1 CDS CGSHiEE_07850 NC_009566.1 1559667 1559885 R COG3082 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1559667..1559885) Haemophilus influenzae PittEE 5226011 YP_001291267.1 CDS CGSHiEE_07855 NC_009566.1 1560012 1561028 D COG3081 Nucleoid-associated protein; nucleoid-associated protein NdpA 1560012..1561028 Haemophilus influenzae PittEE 5226106 YP_001291268.1 CDS CGSHiEE_07860 NC_009566.1 1561094 1561507 D COG2913 Small protein A (tmRNA-binding); small protein A 1561094..1561507 Haemophilus influenzae PittEE 5226107 YP_001291269.1 CDS CGSHiEE_07865 NC_009566.1 1561558 1562241 D COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; nucleoid-associated protein NdpA 1561558..1562241 Haemophilus influenzae PittEE 5226108 YP_001291270.1 CDS CGSHiEE_07870 NC_009566.1 1562337 1562528 D COG0642 Signal transduction histidine kinase; hypothetical protein 1562337..1562528 Haemophilus influenzae PittEE 5226109 YP_001291271.1 CDS CGSHiEE_07875 NC_009566.1 1562579 1562683 D COG0642 Signal transduction histidine kinase; hypothetical protein 1562579..1562683 Haemophilus influenzae PittEE 5226110 YP_001291272.1 CDS CGSHiEE_07880 NC_009566.1 1562720 1563691 R lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase complement(1562720..1563691) Haemophilus influenzae PittEE 5226111 YP_001291273.1 CDS CGSHiEE_07885 NC_009566.1 1563902 1565701 D part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 1563902..1565701 Haemophilus influenzae PittEE 5226112 YP_001291274.1 CDS CGSHiEE_07890 NC_009566.1 1565694 1566464 D part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit 1565694..1566464 Haemophilus influenzae PittEE 5226113 YP_001291275.1 CDS CGSHiEE_07895 NC_009566.1 1566475 1566885 D part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C 1566475..1566885 Haemophilus influenzae PittEE 5226285 YP_001291276.1 CDS CGSHiEE_07900 NC_009566.1 1566898 1567242 D in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 1566898..1567242 Haemophilus influenzae PittEE 5226286 YP_001291277.1 CDS mtgA NC_009566.1 1567368 1568090 R glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase complement(1567368..1568090) Haemophilus influenzae PittEE 5226287 YP_001291278.1 CDS CGSHiEE_07910 NC_009566.1 1568077 1568382 R When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor complement(1568077..1568382) Haemophilus influenzae PittEE 5226288 YP_001291279.1 CDS CGSHiEE_07915 NC_009566.1 1568420 1570201 R COG1196 Chromosome segregation ATPases; putative soluble lytic murein transglycosylase complement(1568420..1570201) Haemophilus influenzae PittEE 5226289 YP_001291280.1 CDS CGSHiEE_07920 NC_009566.1 1570217 1570513 R unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; YciI-like protein complement(1570217..1570513) Haemophilus influenzae PittEE 5226290 YP_001291281.1 CDS CGSHiEE_07925 NC_009566.1 1570530 1570994 R COG1607 Acyl-CoA hydrolase; Trp operon repressor complement(1570530..1570994) Haemophilus influenzae PittEE 5226291 YP_001291282.1 CDS CGSHiEE_07930 NC_009566.1 1570994 1571551 R Involved in cell division; probably involved in intracellular septation; intracellular septation protein A complement(1570994..1571551) Haemophilus influenzae PittEE 5226292 YP_001291283.1 CDS CGSHiEE_07935 NC_009566.1 1571557 1572291 R COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; intracellular septation protein A complement(1571557..1572291) Haemophilus influenzae PittEE 5225677 YP_001291284.1 CDS mglC NC_009566.1 1572437 1573447 R ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane component complement(1572437..1573447) Haemophilus influenzae PittEE 5225678 YP_001291285.1 CDS CGSHiEE_07945 NC_009566.1 1573464 1574984 R with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein complement(1573464..1574984) Haemophilus influenzae PittEE 5225679 YP_001291286.1 CDS CGSHiEE_07950 NC_009566.1 1575050 1576045 R COG1879 ABC-type sugar transport system, periplasmic component; galactose ABC transporter periplasmic-binding protein complement(1575050..1576045) Haemophilus influenzae PittEE 5225680 YP_001291287.1 CDS CGSHiEE_07955 NC_009566.1 1576190 1577188 R COG1609 Transcriptional regulators; methyl-galactoside ABC transporter ATP-binding protein complement(1576190..1577188) Haemophilus influenzae PittEE 5225681 YP_001291288.1 CDS CGSHiEE_07960 NC_009566.1 1577398 1578447 D catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 1577398..1578447 Haemophilus influenzae PittEE 5225682 YP_001291289.1 CDS CGSHiEE_07965 NC_009566.1 1578524 1579678 D catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 1578524..1579678 Haemophilus influenzae PittEE 5225683 YP_001291290.1 CDS galM NC_009566.1 1579688 1580710 D catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase 1579688..1580710 Haemophilus influenzae PittEE 5225684 YP_001291291.1 CDS CGSHiEE_07975 NC_009566.1 1580881 1581429 D the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein 1580881..1581429 Haemophilus influenzae PittEE 5225439 YP_001291292.1 CDS CGSHiEE_07980 NC_009566.1 1581441 1582721 D COG0006 Xaa-Pro aminopeptidase; Xaa-Pro aminopeptidase 1581441..1582721 Haemophilus influenzae PittEE 5225440 YP_001291293.1 CDS CGSHiEE_07985 NC_009566.1 1582835 1583260 D COG0589 Universal stress protein UspA and related nucleotide-binding proteins; universal stress protein A 1582835..1583260 Haemophilus influenzae PittEE 5225441 YP_001291294.1 CDS alaS NC_009566.1 1583449 1586073 D Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1583449..1586073 Haemophilus influenzae PittEE 5225442 YP_001291295.1 CDS CGSHiEE_07995 NC_009566.1 1586151 1586342 D affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator 1586151..1586342 Haemophilus influenzae PittEE 5225443 YP_001291296.1 CDS CGSHiEE_08000 NC_009566.1 1586364 1587251 D COG1210 UDP-glucose pyrophosphorylase; carbon storage regulator 1586364..1587251 Haemophilus influenzae PittEE 5225444 YP_001291297.1 CDS CGSHiEE_08005 NC_009566.1 1587386 1588759 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 1587386..1588759 Haemophilus influenzae PittEE 5225445 YP_001291298.1 CDS hslO NC_009566.1 1588904 1589785 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 1588904..1589785 Haemophilus influenzae PittEE 5225446 YP_001291299.1 CDS CGSHiEE_08015 NC_009566.1 1589959 1591575 D PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 1589959..1591575 Haemophilus influenzae PittEE 5225519 YP_001291300.1 CDS frr NC_009566.1 1591765 1592286 D COG0233 Ribosome recycling factor; ribosome recycling factor 1591765..1592286 Haemophilus influenzae PittEE 5225520 YP_001291301.1 CDS CGSHiEE_08025 NC_009566.1 1592396 1593589 D catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1592396..1593589 Haemophilus influenzae PittEE 5225521 YP_001291302.1 CDS CGSHiEE_08030 NC_009566.1 1593621 1594430 R COG0730 Predicted permeases; permease complement(1593621..1594430) Haemophilus influenzae PittEE 5225522 YP_001291303.1 CDS CGSHiEE_08035 NC_009566.1 1594564 1595643 D COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); hypothetical protein 1594564..1595643 Haemophilus influenzae PittEE 5225523 YP_001291304.1 CDS CGSHiEE_08040 NC_009566.1 1596107 1596358 D COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1596107..1596358 Haemophilus influenzae PittEE 5225524 YP_001291305.1 CDS rplQ NC_009566.1 1596486 1596872 R is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 complement(1596486..1596872) Haemophilus influenzae PittEE 5225525 YP_001291306.1 CDS CGSHiEE_08050 NC_009566.1 1596913 1597899 R catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha complement(1596913..1597899) Haemophilus influenzae PittEE 5225526 YP_001291307.1 CDS rpsD NC_009566.1 1597931 1598551 R primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 complement(1597931..1598551) Haemophilus influenzae PittEE 5225795 YP_001291308.1 CDS CGSHiEE_08060 NC_009566.1 1598579 1598968 R located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 complement(1598579..1598968) Haemophilus influenzae PittEE 5225796 YP_001291309.1 CDS rpsM NC_009566.1 1598984 1599340 R located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 complement(1598984..1599340) Haemophilus influenzae PittEE 5225797 YP_001291310.1 CDS rpmJ NC_009566.1 1599480 1599593 R smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 complement(1599480..1599593) Haemophilus influenzae PittEE 5225798 YP_001291311.1 CDS secY NC_009566.1 1599622 1600947 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(1599622..1600947) Haemophilus influenzae PittEE 5225799 YP_001291312.1 CDS rplO NC_009566.1 1600955 1601389 R late assembly protein; 50S ribosomal protein L15 complement(1600955..1601389) Haemophilus influenzae PittEE 5225800 YP_001291313.1 CDS rpmD NC_009566.1 1601393 1601572 R L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 complement(1601393..1601572) Haemophilus influenzae PittEE 5225801 YP_001291314.1 CDS rpsE NC_009566.1 1601579 1602079 R located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 complement(1601579..1602079) Haemophilus influenzae PittEE 5225802 YP_001291315.1 CDS rplR NC_009566.1 1602094 1602447 R binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 complement(1602094..1602447) Haemophilus influenzae PittEE 5225837 YP_001291316.1 CDS rplF NC_009566.1 1602461 1602994 R ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 complement(1602461..1602994) Haemophilus influenzae PittEE 5225838 YP_001291317.1 CDS rpsH NC_009566.1 1603010 1603402 R binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 complement(1603010..1603402) Haemophilus influenzae PittEE 5225839 YP_001291318.1 CDS rpsN NC_009566.1 1603356 1603745 R COG0199 Ribosomal protein S14; 30S ribosomal protein S14 complement(1603356..1603745) Haemophilus influenzae PittEE 5225840 YP_001291319.1 CDS rplE NC_009566.1 1603757 1604296 R part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 complement(1603757..1604296) Haemophilus influenzae PittEE 5225841 YP_001291320.1 CDS rplX NC_009566.1 1604314 1604625 R assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 complement(1604314..1604625) Haemophilus influenzae PittEE 5225842 YP_001291321.1 CDS rplN NC_009566.1 1604636 1605007 R binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 complement(1604636..1605007) Haemophilus influenzae PittEE 5225843 YP_001291322.1 CDS rpsQ NC_009566.1 1605240 1605497 R primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 complement(1605240..1605497) Haemophilus influenzae PittEE 5225844 YP_001291323.1 CDS CGSHiEE_08135 NC_009566.1 1605497 1605688 R one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 complement(1605497..1605688) Haemophilus influenzae PittEE 5225845 YP_001291324.1 CDS rplP NC_009566.1 1605688 1606098 R located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 complement(1605688..1606098) Haemophilus influenzae PittEE 5225906 YP_001291325.1 CDS rpsC NC_009566.1 1606112 1606819 R forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 complement(1606112..1606819) Haemophilus influenzae PittEE 5225907 YP_001291326.1 CDS rplV NC_009566.1 1606837 1607169 R binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 complement(1606837..1607169) Haemophilus influenzae PittEE 5225908 YP_001291327.1 CDS rpsS NC_009566.1 1607181 1607456 R protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 complement(1607181..1607456) Haemophilus influenzae PittEE 5225909 YP_001291328.1 CDS rplB NC_009566.1 1607482 1608303 R one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 complement(1607482..1608303) Haemophilus influenzae PittEE 5225910 YP_001291329.1 CDS rplW NC_009566.1 1608290 1608619 R COG0089 Ribosomal protein L23; 50S ribosomal protein L23 complement(1608290..1608619) Haemophilus influenzae PittEE 5225911 YP_001291330.1 CDS rplD NC_009566.1 1608616 1609218 R L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 complement(1608616..1609218) Haemophilus influenzae PittEE 5225912 YP_001291331.1 CDS rplC NC_009566.1 1609876 1610187 R COG0051 Ribosomal protein S10; 50S ribosomal protein L3 complement(1609876..1610187) Haemophilus influenzae PittEE 5225913 YP_001291332.1 CDS CGSHiEE_08190 NC_009566.1 1610461 1612038 R COG1070 Sugar (pentulose and hexulose) kinases; autoinducer-2 (AI-2) kinase complement(1610461..1612038) Haemophilus influenzae PittEE 5226022 YP_001291333.1 CDS CGSHiEE_08195 NC_009566.1 1612081 1613046 R COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain; hypothetical protein complement(1612081..1613046) Haemophilus influenzae PittEE 5226023 YP_001291334.1 CDS CGSHiEE_08210 NC_009566.1 1614802 1615782 D COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; hypothetical protein 1614802..1615782 Haemophilus influenzae PittEE 5226024 YP_001291335.1 CDS CGSHiEE_08215 NC_009566.1 1615826 1616830 D COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; hypothetical protein 1615826..1616830 Haemophilus influenzae PittEE 5226025 YP_001291336.1 CDS CGSHiEE_08220 NC_009566.1 1616866 1617882 D COG1879 ABC-type sugar transport system, periplasmic component; autoinducer-2 (AI-2) kinase 1616866..1617882 Haemophilus influenzae PittEE 5226026 YP_001291337.1 CDS CGSHiEE_08225 NC_009566.1 1617898 1618782 D COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes; aldolase 1617898..1618782 Haemophilus influenzae PittEE 5226027 YP_001291338.1 CDS CGSHiEE_08230 NC_009566.1 1618847 1619140 D COG1359 Uncharacterized conserved protein; autoinducer-2 (AI-2) modifying protein LsrG 1618847..1619140 Haemophilus influenzae PittEE 5226028 YP_001291339.1 CDS CGSHiEE_08235 NC_009566.1 1619149 1619841 D catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 1619149..1619841 Haemophilus influenzae PittEE 5226029 YP_001291340.1 CDS ftsX NC_009566.1 1619920 1620849 R putative ABC transporter, membrane protein; cell division protein FtsX complement(1619920..1620849) Haemophilus influenzae PittEE 5224685 YP_001291341.1 CDS CGSHiEE_08245 NC_009566.1 1620859 1621515 R COG2884 Predicted ATPase involved in cell division; cell division ATP-binding protein complement(1620859..1621515) Haemophilus influenzae PittEE 5224686 YP_001291342.1 CDS CGSHiEE_08250 NC_009566.1 1621534 1622736 R COG0552 Signal recognition particle GTPase; cell division protein FtsY complement(1621534..1622736) Haemophilus influenzae PittEE 5224687 YP_001291343.1 CDS CGSHiEE_08255 NC_009566.1 1622833 1623414 D COG0742 N6-adenine-specific methylase; hypothetical protein 1622833..1623414 Haemophilus influenzae PittEE 5224688 YP_001291344.1 CDS CGSHiEE_08260 NC_009566.1 1623425 1623907 D COG0219 Predicted rRNA methylase (SpoU class); putative RNA methyltransferase 1623425..1623907 Haemophilus influenzae PittEE 5224689 YP_001291345.1 CDS ftsX NC_009566.1 1623955 1624791 R COG3306 Glycosyltransferase involved in LPS biosynthesis; membrane component of ABC transporter FtsEX complement(1623955..1624791) Haemophilus influenzae PittEE 5224690 YP_001291346.1 CDS ribB NC_009566.1 1624818 1625465 R DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase complement(1624818..1625465) Haemophilus influenzae PittEE 5224691 YP_001291347.1 CDS CGSHiEE_08285 NC_009566.1 1626947 1627627 D COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases; nicotinamide-nucleotide adenylyltransferase 1626947..1627627 Haemophilus influenzae PittEE 5224692 YP_001291348.1 CDS mltC NC_009566.1 1628238 1629311 R Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C complement(1628238..1629311) Haemophilus influenzae PittEE 5225555 YP_001291349.1 CDS CGSHiEE_08295 NC_009566.1 1629326 1629598 R COG2924 Fe-S cluster protector protein; hypothetical protein complement(1629326..1629598) Haemophilus influenzae PittEE 5225556 YP_001291350.1 CDS CGSHiEE_08300 NC_009566.1 1629576 1630712 R COG1194 A/G-specific DNA glycosylase; hypothetical protein complement(1629576..1630712) Haemophilus influenzae PittEE 5225557 YP_001291351.1 CDS rpmE NC_009566.1 1630889 1631101 D RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1630889..1631101 Haemophilus influenzae PittEE 5225558 YP_001291352.1 CDS CGSHiEE_08310 NC_009566.1 1631179 1631862 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(1631179..1631862) Haemophilus influenzae PittEE 5225559 YP_001291353.1 CDS CGSHiEE_08325 NC_009566.1 1633269 1634111 D COG2861 Uncharacterized protein conserved in bacteria; hypothetical protein 1633269..1634111 Haemophilus influenzae PittEE 5225560 YP_001291354.1 CDS rpmE NC_009566.1 1634172 1634915 R 50S ribosomal protein L31 complement(1634172..1634915) Haemophilus influenzae PittEE 5225561 YP_001291355.1 CDS CGSHiEE_08335 NC_009566.1 1634929 1635186 R COG3306 Glycosyltransferase involved in LPS biosynthesis; hypothetical protein complement(1634929..1635186) Haemophilus influenzae PittEE 5225562 YP_001291356.1 CDS CGSHiEE_08340 NC_009566.1 1635446 1639339 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase complement(1635446..1639339) Haemophilus influenzae PittEE 5225980 YP_001291357.1 CDS CGSHiEE_08345 NC_009566.1 1639745 1640071 D COG3477 Predicted periplasmic/secreted protein; hypothetical protein 1639745..1640071 Haemophilus influenzae PittEE 5225981 YP_001291358.1 CDS tpx NC_009566.1 1640125 1640622 D antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1640125..1640622 Haemophilus influenzae PittEE 5225982 YP_001291359.1 CDS dapF NC_009566.1 1640842 1641666 R involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase complement(1640842..1641666) Haemophilus influenzae PittEE 5225983 YP_001291360.1 CDS CGSHiEE_08360 NC_009566.1 1641809 1642432 R Represses a number of genes involved in the response to DNA damage; LexA repressor complement(1641809..1642432) Haemophilus influenzae PittEE 5225984 YP_001291361.1 CDS CGSHiEE_08365 NC_009566.1 1642686 1645118 D PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 1642686..1645118 Haemophilus influenzae PittEE 5225985 YP_001291362.1 CDS CGSHiEE_08370 NC_009566.1 1645198 1646532 R COG1252 NADH dehydrogenase, FAD-containing subunit; glycerol-3-phosphate acyltransferase complement(1645198..1646532) Haemophilus influenzae PittEE 5225986 YP_001291363.1 CDS CGSHiEE_08375 NC_009566.1 1646737 1648059 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter complement(1646737..1648059) Haemophilus influenzae PittEE 5225987 YP_001291364.1 CDS ansB NC_009566.1 1648217 1649266 R catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II complement(1648217..1649266) Haemophilus influenzae PittEE 5225988 YP_001291365.1 CDS ansB NC_009566.1 1649492 1649938 D COG0607 Rhodanese-related sulfurtransferase; L-asparaginase II 1649492..1649938 Haemophilus influenzae PittEE 5225969 YP_001291366.1 CDS CGSHiEE_08390 NC_009566.1 1649952 1650461 D molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 1649952..1650461 Haemophilus influenzae PittEE 5225970 YP_001291367.1 CDS CGSHiEE_08395 NC_009566.1 1650528 1650842 R hypothetical protein complement(1650528..1650842) Haemophilus influenzae PittEE 5225971 YP_001291369.1 CDS CGSHiEE_08405 NC_009566.1 1651006 1652658 R COG1109 Phosphomannomutase; export protein SecB complement(1651006..1652658) Haemophilus influenzae PittEE 5225973 YP_001291370.1 CDS CGSHiEE_08420 NC_009566.1 1656417 1657958 R threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase complement(1656417..1657958) Haemophilus influenzae PittEE 5225974 YP_001291371.1 CDS CGSHiEE_08425 NC_009566.1 1658039 1659877 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(1658039..1659877) Haemophilus influenzae PittEE 5225975 YP_001291372.1 CDS CGSHiEE_08430 NC_009566.1 1659919 1660716 R COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; acetohydroxy acid synthase II complement(1659919..1660716) Haemophilus influenzae PittEE 5225976 YP_001291373.1 CDS CGSHiEE_08435 NC_009566.1 1660963 1662489 D dihydroxy-acid dehydratase 1660963..1662489 Haemophilus influenzae PittEE 5225492 YP_001291374.1 CDS CGSHiEE_08440 NC_009566.1 1662491 1662586 D COG0733 Na+-dependent transporters of the SNF family; hypothetical protein 1662491..1662586 Haemophilus influenzae PittEE 5225493 YP_001291375.1 CDS CGSHiEE_08445 NC_009566.1 1662719 1663432 R catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase complement(1662719..1663432) Haemophilus influenzae PittEE 5225494 YP_001291376.1 CDS CGSHiEE_08450 NC_009566.1 1663518 1664240 D COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; 1-acyl-sn-glycerol-3-phosphate acyltransferase 1663518..1664240 Haemophilus influenzae PittEE 5225495 YP_001291377.1 CDS CGSHiEE_08455 NC_009566.1 1664242 1665651 D COG2132 Putative multicopper oxidases; UDP-2,3-diacylglucosamine hydrolase 1664242..1665651 Haemophilus influenzae PittEE 5225496 YP_001291378.1 CDS CGSHiEE_08470 NC_009566.1 1668208 1669926 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(1668208..1669926) Haemophilus influenzae PittEE 5225497 YP_001291379.1 CDS CGSHiEE_08475 NC_009566.1 1670022 1671869 R COG0514 Superfamily II DNA helicase; prolyl-tRNA synthetase complement(1670022..1671869) Haemophilus influenzae PittEE 5225498 YP_001291380.1 CDS cyaY NC_009566.1 1671871 1672176 R defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein complement(1671871..1672176) Haemophilus influenzae PittEE 5225499 YP_001291381.1 CDS CGSHiEE_08485 NC_009566.1 1672274 1672390 D COG5567 Predicted small periplasmic lipoprotein; hypothetical protein 1672274..1672390 Haemophilus influenzae PittEE 5225886 YP_001291382.1 CDS CGSHiEE_08490 NC_009566.1 1672438 1673790 D COG0019 Diaminopimelate decarboxylase; diaminopimelate decarboxylase 1672438..1673790 Haemophilus influenzae PittEE 5225887 YP_001291383.1 CDS CGSHiEE_08495 NC_009566.1 1673892 1674518 D nitrate/nitrite response regulator protein 1673892..1674518 Haemophilus influenzae PittEE 5225888 YP_001291384.1 CDS cyaY NC_009566.1 1674580 1675020 R COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; hypothetical protein complement(1674580..1675020) Haemophilus influenzae PittEE 5225889 YP_001291385.1 CDS CGSHiEE_08505 NC_009566.1 1675024 1675584 R COG3078 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1675024..1675584) Haemophilus influenzae PittEE 5225890 YP_001291386.1 CDS CGSHiEE_08510 NC_009566.1 1681925 1683301 R COG0168 Trk-type K+ transport systems, membrane components; Trk system potassium uptake protein TrkH complement(1681925..1683301) Haemophilus influenzae PittEE 5225893 YP_001291387.1 CDS CGSHiEE_08515 NC_009566.1 1683304 1683936 R COG1739 Uncharacterized conserved protein; hypothetical protein complement(1683304..1683936) Haemophilus influenzae PittEE 5225540 YP_001291388.1 CDS CGSHiEE_08520 NC_009566.1 1684039 1684278 D TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 1684039..1684278 Haemophilus influenzae PittEE 5225541 YP_001291389.1 CDS CGSHiEE_08525 NC_009566.1 1684320 1685171 R putative metalloprotease; heat shock protein HtpX complement(1684320..1685171) Haemophilus influenzae PittEE 5225542 YP_001291390.1 CDS CGSHiEE_08530 NC_009566.1 1685339 1685728 R COG0251 Putative translation initiation inhibitor, yjgF family; putative translation initiation inhibitor, YjgF family protein complement(1685339..1685728) Haemophilus influenzae PittEE 5225543 YP_001291391.1 CDS CGSHiEE_08535 NC_009566.1 1685785 1686519 R COG2853 Surface lipoprotein; heat shock protein HtpX complement(1685785..1686519) Haemophilus influenzae PittEE 5225544 YP_001291392.1 CDS nusG NC_009566.1 1686689 1687246 R Modulates Rho-dependent transcription termination; transcription antitermination protein NusG complement(1686689..1687246) Haemophilus influenzae PittEE 5225545 YP_001291393.1 CDS secE NC_009566.1 1687248 1687664 R forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE complement(1687248..1687664) Haemophilus influenzae PittEE 5225546 YP_001291394.1 CDS clpX NC_009566.1 1687808 1689043 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(1687808..1689043) Haemophilus influenzae PittEE 5225547 YP_001291395.1 CDS clpP NC_009566.1 1689053 1689634 R hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit complement(1689053..1689634) Haemophilus influenzae PittEE 5226240 YP_001291396.1 CDS tig NC_009566.1 1689757 1691055 R Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor complement(1689757..1691055) Haemophilus influenzae PittEE 5226241 YP_001291397.1 CDS CGSHiEE_08565 NC_009566.1 1691408 1691530 D COG0544 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor); hypothetical protein 1691408..1691530 Haemophilus influenzae PittEE 5226242 YP_001291398.1 CDS CGSHiEE_08580 NC_009566.1 1694661 1694969 R COG3041 Uncharacterized protein conserved in bacteria; hypothetical protein complement(1694661..1694969) Haemophilus influenzae PittEE 5226243 YP_001291399.1 CDS CGSHiEE_08585 NC_009566.1 1694969 1695265 R hypothetical protein complement(1694969..1695265) Haemophilus influenzae PittEE 5226244 YP_001291400.1 CDS CGSHiEE_08590 NC_009566.1 1695386 1696240 R COG3077 DNA-damage-inducible protein J; hypothetical protein complement(1695386..1696240) Haemophilus influenzae PittEE 5226245 YP_001291401.1 CDS tig NC_009566.1 1696259 1698118 R COG3276 Selenocysteine-specific translation elongation factor; selenocysteine-specific elongation factor complement(1696259..1698118) Haemophilus influenzae PittEE 5226246 YP_001291402.1 CDS CGSHiEE_08600 NC_009566.1 1698115 1699500 R catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase complement(1698115..1699500) Haemophilus influenzae PittEE 5225455 YP_001291403.1 CDS CGSHiEE_08605 NC_009566.1 1699911 1700999 D COG1672 Predicted ATPase (AAA+ superfamily); selenocysteine synthase 1699911..1700999 Haemophilus influenzae PittEE 5225456 YP_001291404.1 CDS CGSHiEE_08610 NC_009566.1 1701389 1703974 R This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS complement(1701389..1703974) Haemophilus influenzae PittEE 5225457 YP_001291405.1 CDS CGSHiEE_08615 NC_009566.1 1704108 1705325 R COG0739 Membrane proteins related to metalloendopeptidases; lipoprotein complement(1704108..1705325) Haemophilus influenzae PittEE 5225458 YP_001291406.1 CDS CGSHiEE_08620 NC_009566.1 1705349 1705534 R COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases; hypothetical protein complement(1705349..1705534) Haemophilus influenzae PittEE 5225459 YP_001291407.1 CDS CGSHiEE_08625 NC_009566.1 1705543 1706085 R COG1238 Predicted membrane protein; DNA mismatch repair protein complement(1705543..1706085) Haemophilus influenzae PittEE 5225460 YP_001291408.1 CDS surE NC_009566.1 1706132 1706881 R catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE complement(1706132..1706881) Haemophilus influenzae PittEE 5225461 YP_001291409.1 CDS truD NC_009566.1 1706891 1707910 R catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D complement(1706891..1707910) Haemophilus influenzae PittEE 5225462 YP_001291410.1 CDS CGSHiEE_08640 NC_009566.1 1708019 1708441 D COG3076 Uncharacterized protein conserved in bacteria; hypothetical protein 1708019..1708441 Haemophilus influenzae PittEE 5225463 YP_001291411.1 CDS CGSHiEE_08645 NC_009566.1 1708519 1709091 D COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2; FKBP-type peptidyl-prolyl cis-trans isomerase SlyD 1708519..1709091 Haemophilus influenzae PittEE 5225668 YP_001291412.1 CDS CGSHiEE_08650 NC_009566.1 1709242 1710978 D COG0729 Outer membrane protein; hypothetical protein 1709242..1710978 Haemophilus influenzae PittEE 5225669 YP_001291413.1 CDS CGSHiEE_08655 NC_009566.1 1710988 1714884 D COG2911 Uncharacterized protein conserved in bacteria; hypothetical protein 1710988..1714884 Haemophilus influenzae PittEE 5225670 YP_001291414.1 CDS CGSHiEE_08660 NC_009566.1 1714892 1715869 D COG0248 Exopolyphosphatase; exopolyphosphatase 1714892..1715869 Haemophilus influenzae PittEE 5225671 YP_001291415.1 CDS CGSHiEE_08665 NC_009566.1 1715982 1716665 R COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; hypothetical protein complement(1715982..1716665) Haemophilus influenzae PittEE 5225672 YP_001291416.1 CDS CGSHiEE_08670 NC_009566.1 1716844 1717668 R COG2503 Predicted secreted acid phosphatase; hypothetical protein complement(1716844..1717668) Haemophilus influenzae PittEE 5225673 YP_001291417.1 CDS glpQ NC_009566.1 1717794 1717979 R COG0584 Glycerophosphoryl diester phosphodiesterase; glycerophosphodiester phosphodiesterase complement(1717794..1717979) Haemophilus influenzae PittEE 5225674 YP_001291418.1 CDS CGSHiEE_08680 NC_009566.1 1718240 1719718 R catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase complement(1718240..1719718) Haemophilus influenzae PittEE 5225675 YP_001291419.1 CDS CGSHiEE_08685 NC_009566.1 1719997 1720062 R COG0059 Ketol-acid reductoisomerase; hypothetical protein complement(1719997..1720062) Haemophilus influenzae PittEE 5225676 YP_001291420.1 CDS CGSHiEE_08690 NC_009566.1 1720061 1720861 D participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 1720061..1720861 Haemophilus influenzae PittEE 5225577 YP_001291421.1 CDS CGSHiEE_08695 NC_009566.1 1720893 1721771 D COG2962 Predicted permeases; hypothetical protein 1720893..1721771 Haemophilus influenzae PittEE 5225578 YP_001291422.1 CDS CGSHiEE_08700 NC_009566.1 1721772 1722089 D COG0607 Rhodanese-related sulfurtransferase; DNA-binding transcriptional regulator IlvY 1721772..1722089 Haemophilus influenzae PittEE 5225579 YP_001291423.1 CDS tpiA NC_009566.1 1722172 1722963 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(1722172..1722963) Haemophilus influenzae PittEE 5225580 YP_001291424.1 CDS tpiA NC_009566.1 1723128 1723568 D COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; triosephosphate isomerase 1723128..1723568 Haemophilus influenzae PittEE 5225581 YP_001291425.1 CDS xerC NC_009566.1 1723562 1724449 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 1723562..1724449 Haemophilus influenzae PittEE 5225582 YP_001291426.1 CDS xerC NC_009566.1 1724502 1725956 R COG2195 Di- and tripeptidases; site-specific tyrosine recombinase XerC complement(1724502..1725956) Haemophilus influenzae PittEE 5225583 YP_001291427.1 CDS CGSHiEE_08725 NC_009566.1 1726067 1726534 D catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 1726067..1726534 Haemophilus influenzae PittEE 5225584 YP_001291428.1 CDS glpK NC_009566.1 1726618 1728129 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(1726618..1728129) Haemophilus influenzae PittEE 5225585 YP_001291429.1 CDS glpQ NC_009566.1 1729162 1730256 R hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase complement(1729162..1730256) Haemophilus influenzae PittEE 5225803 YP_001291430.1 CDS glpQ NC_009566.1 1730360 1731802 R COG2271 Sugar phosphate permease; glycerophosphodiester phosphodiesterase complement(1730360..1731802) Haemophilus influenzae PittEE 5225804 YP_001291431.1 CDS glpA NC_009566.1 1732092 1733783 D anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 1732092..1733783 Haemophilus influenzae PittEE 5225805 YP_001291432.1 CDS CGSHiEE_08760 NC_009566.1 1733773 1735071 D sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 1733773..1735071 Haemophilus influenzae PittEE 5225806 YP_001291433.1 CDS glpC NC_009566.1 1735083 1736363 D anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 1735083..1736363 Haemophilus influenzae PittEE 5225807 YP_001291434.1 CDS CGSHiEE_08770 NC_009566.1 1736679 1737350 D COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components; ferrichrome ABC transporter ATP-binding protein 1736679..1737350 Haemophilus influenzae PittEE 5225808 YP_001291435.1 CDS glpC NC_009566.1 1737352 1738236 D sn-glycerol-3-phosphate dehydrogenase subunit C 1737352..1738236 Haemophilus influenzae PittEE 5225809 YP_001291436.1 CDS CGSHiEE_08780 NC_009566.1 1738223 1738402 D COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component; hypothetical protein 1738223..1738402 Haemophilus influenzae PittEE 5225810 YP_001291437.1 CDS CGSHiEE_08785 NC_009566.1 1738230 1740200 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 1738230..1740200 Haemophilus influenzae PittEE 5225408 YP_001291438.1 CDS CGSHiEE_08790 NC_009566.1 1740319 1742490 D COG1629 Outer membrane receptor proteins, mostly Fe transport; putative ferric siderophore receptor 1740319..1742490 Haemophilus influenzae PittEE 5225409 YP_001291439.1 CDS CGSHiEE_08795 NC_009566.1 1742777 1743115 D COG2801 Transposase and inactivated derivatives; iron-hydroxamate transporter permease subunit 1742777..1743115 Haemophilus influenzae PittEE 5225410 YP_001291440.1 CDS CGSHiEE_08800 NC_009566.1 1743365 1743832 D catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 1743365..1743832 Haemophilus influenzae PittEE 5225411 YP_001291442.1 CDS ftsB NC_009566.1 1743955 1744233 D forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB 1743955..1744233 Haemophilus influenzae PittEE 5225413 YP_001291443.1 CDS ispD NC_009566.1 1744233 1744910 D 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1744233..1744910 Haemophilus influenzae PittEE 5225414 YP_001291444.1 CDS ispF NC_009566.1 1744907 1745383 D catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 1744907..1745383 Haemophilus influenzae PittEE 5225415 YP_001291445.1 CDS CGSHiEE_08825 NC_009566.1 1745685 1746119 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(1745685..1746119) Haemophilus influenzae PittEE 5225416 YP_001291446.1 CDS CGSHiEE_08830 NC_009566.1 1746116 1746556 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(1746116..1746556) Haemophilus influenzae PittEE 5225500 YP_001291447.1 CDS CGSHiEE_08835 NC_009566.1 1746651 1746869 R COG3074 Uncharacterized protein conserved in bacteria; flavodoxin complement(1746651..1746869) Haemophilus influenzae PittEE 5225501 YP_001291448.1 CDS CGSHiEE_08850 NC_009566.1 1748233 1748541 D COG1396 Predicted transcriptional regulators; hypothetical protein 1748233..1748541 Haemophilus influenzae PittEE 5225502 YP_001291449.1 CDS CGSHiEE_08855 NC_009566.1 1748529 1748849 D COG3550 Uncharacterized protein related to capsule biosynthesis enzymes; hypothetical protein 1748529..1748849 Haemophilus influenzae PittEE 5225503 YP_001291450.1 CDS CGSHiEE_08860 NC_009566.1 1748846 1749877 D COG3550 Uncharacterized protein related to capsule biosynthesis enzymes; hypothetical protein 1748846..1749877 Haemophilus influenzae PittEE 5225504 YP_001291451.1 CDS CGSHiEE_08865 NC_009566.1 1749961 1751619 R COG1132 ABC-type multidrug transport system, ATPase and permease components; ABC transporter ATP-binding protein complement(1749961..1751619) Haemophilus influenzae PittEE 5225505 YP_001291452.1 CDS CGSHiEE_08870 NC_009566.1 1751612 1753357 R ABC transporter ATP-binding protein complement(1751612..1753357) Haemophilus influenzae PittEE 5225506 YP_001291453.1 CDS CGSHiEE_08875 NC_009566.1 1753410 1753574 R hypothetical protein complement(1753410..1753574) Haemophilus influenzae PittEE 5225507 YP_001291454.1 CDS CGSHiEE_08880 NC_009566.1 1753919 1754041 D hypothetical protein 1753919..1754041 Haemophilus influenzae PittEE 5225508 YP_001291455.1 CDS CGSHiEE_08885 NC_009566.1 1753947 1754135 D COG4988 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components; hypothetical protein 1753947..1754135 Haemophilus influenzae PittEE 5226312 YP_001291456.1 CDS CGSHiEE_08890 NC_009566.1 1754182 1757136 D COG1629 Outer membrane receptor proteins, mostly Fe transport; hemoglobin-binding protein 1754182..1757136 Haemophilus influenzae PittEE 5226313 YP_001291457.1 CDS CGSHiEE_08895 NC_009566.1 1757406 1757765 D COG4679 Phage-related protein; hypothetical protein 1757406..1757765 Haemophilus influenzae PittEE 5226314 YP_001291458.1 CDS CGSHiEE_08900 NC_009566.1 1757758 1758054 D COG1396 Predicted transcriptional regulators; putative HTH-type transcriptional regulator 1757758..1758054 Haemophilus influenzae PittEE 5226315 YP_001291459.1 CDS CGSHiEE_08905 NC_009566.1 1758171 1760087 D COG0488 ATPase components of ABC transporters with duplicated ATPase domains; ABC transporter ATP-binding protein 1758171..1760087 Haemophilus influenzae PittEE 5226316 YP_001291460.1 CDS CGSHiEE_08910 NC_009566.1 1760097 1760633 D COG0551 Zn-finger domain associated with topoisomerase type I; hypothetical protein 1760097..1760633 Haemophilus influenzae PittEE 5226317 YP_001291461.1 CDS glpX NC_009566.1 1760649 1761200 D COG0009 Putative translation factor (SUA5); fructose 1,6-bisphosphatase II 1760649..1761200 Haemophilus influenzae PittEE 5226318 YP_001291462.1 CDS aroE NC_009566.1 1761204 1762010 D AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 1761204..1762010 Haemophilus influenzae PittEE 5226319 YP_001291463.1 CDS CGSHiEE_08925 NC_009566.1 1762022 1762780 D COG0169 Shikimate 5-dehydrogenase; hypothetical protein 1762022..1762780 Haemophilus influenzae PittEE 5226320 YP_001291464.1 CDS CGSHiEE_08930 NC_009566.1 1762889 1763452 D COG2818 3-methyladenine DNA glycosylase; DNA-3-methyladenine glycosylase 1762889..1763452 Haemophilus influenzae PittEE 5224675 YP_001291465.1 CDS aroE NC_009566.1 1763449 1764213 R COG0463 Glycosyltransferases involved in cell wall biogenesis; shikimate 5-dehydrogenase complement(1763449..1764213) Haemophilus influenzae PittEE 5224676 YP_001291466.1 CDS CGSHiEE_08940 NC_009566.1 1764278 1765558 D catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 1764278..1765558 Haemophilus influenzae PittEE 5224677 YP_001291467.1 CDS coaD NC_009566.1 1765555 1766025 D Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1765555..1766025 Haemophilus influenzae PittEE 5224678 YP_001291468.1 CDS CGSHiEE_08950 NC_009566.1 1766022 1766234 D COG0669 Phosphopantetheine adenylyltransferase; periplasmic lipoprotein 1766022..1766234 Haemophilus influenzae PittEE 5224679 YP_001291469.1 CDS CGSHiEE_08955 NC_009566.1 1766240 1768255 D COG0210 Superfamily I DNA and RNA helicases; ATP-dependent DNA helicase 1766240..1768255 Haemophilus influenzae PittEE 5224680 YP_001291470.1 CDS CGSHiEE_08960 NC_009566.1 1768574 1769245 R COG0583 Transcriptional regulator; LysR family transcriptional regulator complement(1768574..1769245) Haemophilus influenzae PittEE 5224681 YP_001291471.1 CDS CGSHiEE_08965 NC_009566.1 1769359 1769937 D putative NADPH-quinone reductase, modulator of drug activity B 1769359..1769937 Haemophilus influenzae PittEE 5224682 YP_001291472.1 CDS CGSHiEE_08970 NC_009566.1 1769930 1770136 D COG2249 Putative NADPH-quinone reductase (modulator of drug activity B); hypothetical protein 1769930..1770136 Haemophilus influenzae PittEE 5224683 YP_001291473.1 CDS coaD NC_009566.1 1770215 1770931 D COG1285 Uncharacterized membrane protein; phosphopantetheine adenylyltransferase 1770215..1770931 Haemophilus influenzae PittEE 5224684 YP_001291474.1 CDS CGSHiEE_08980 NC_009566.1 1771097 1772212 D catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 1771097..1772212 Haemophilus influenzae PittEE 5225954 YP_001291475.1 CDS CGSHiEE_08985 NC_009566.1 1772267 1773208 D COG2267 Lysophospholipase; lysophospholipase L2 1772267..1773208 Haemophilus influenzae PittEE 5225955 YP_001291476.1 CDS CGSHiEE_08990 NC_009566.1 1773363 1774463 D COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit; cytochrome C-like protein 1773363..1774463 Haemophilus influenzae PittEE 5225956 YP_001291477.1 CDS CGSHiEE_09005 NC_009566.1 1777674 1777985 D COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family); aspartate-semialdehyde dehydrogenase 1777674..1777985 Haemophilus influenzae PittEE 5225957 YP_001291478.1 CDS glmU NC_009566.1 1778027 1779397 R forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase complement(1778027..1779397) Haemophilus influenzae PittEE 5225958 YP_001291479.1 CDS rplL NC_009566.1 1779556 1779927 R present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 complement(1779556..1779927) Haemophilus influenzae PittEE 5225959 YP_001291480.1 CDS rplJ NC_009566.1 1779982 1780473 R binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 complement(1779982..1780473) Haemophilus influenzae PittEE 5225960 YP_001291481.1 CDS CGSHiEE_09025 NC_009566.1 1780745 1782115 R Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase complement(1780745..1782115) Haemophilus influenzae PittEE 5225961 YP_001291482.1 CDS CGSHiEE_09030 NC_009566.1 1782138 1782755 R HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein complement(1782138..1782755) Haemophilus influenzae PittEE 5225386 YP_001291483.1 CDS CGSHiEE_09035 NC_009566.1 1782884 1783888 D catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 1782884..1783888 Haemophilus influenzae PittEE 5225387 YP_001291484.1 CDS CGSHiEE_09040 NC_009566.1 1783963 1784199 D COG3691 Uncharacterized protein conserved in bacteria; tryptophanyl-tRNA synthetase 1783963..1784199 Haemophilus influenzae PittEE 5225388 YP_001291485.1 CDS CGSHiEE_09045 NC_009566.1 1784247 1785230 R COG0042 tRNA-dihydrouridine synthase; tRNA-dihydrouridine synthase A complement(1784247..1785230) Haemophilus influenzae PittEE 5225389 YP_001291486.1 CDS CGSHiEE_09050 NC_009566.1 1785233 1785409 R COG0038 Chloride channel protein EriC; chloride channel protein complement(1785233..1785409) Haemophilus influenzae PittEE 5225390 YP_001291487.1 CDS CGSHiEE_09055 NC_009566.1 1785406 1785684 R COG0038 Chloride channel protein EriC; chloride channel protein complement(1785406..1785684) Haemophilus influenzae PittEE 5225391 YP_001291488.1 CDS CGSHiEE_09060 NC_009566.1 1786210 1787394 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(1786210..1787394) Haemophilus influenzae PittEE 5225392 YP_001291489.1 CDS CGSHiEE_09065 NC_009566.1 1787912 1788004 D COG0050 GTPases - translation elongation factors; hypothetical protein 1787912..1788004 Haemophilus influenzae PittEE 5225393 YP_001291490.1 CDS rseB NC_009566.1 1789116 1790063 R periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE complement(1789116..1790063) Haemophilus influenzae PittEE 5225394 YP_001291491.1 CDS rseB NC_009566.1 1790143 1790730 R COG3073 Negative regulator of sigma E activity; periplasmic negative regulator of sigmaE complement(1790143..1790730) Haemophilus influenzae PittEE 5225568 YP_001291492.1 CDS CGSHiEE_09090 NC_009566.1 1790755 1791324 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE complement(1790755..1791324) Haemophilus influenzae PittEE 5225569 YP_001291493.1 CDS CGSHiEE_09095 NC_009566.1 1791423 1791689 R COG2938 Uncharacterized conserved protein; hypothetical protein complement(1791423..1791689) Haemophilus influenzae PittEE 5225570 YP_001291494.1 CDS mscL NC_009566.1 1791780 1792166 R forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel complement(1791780..1792166) Haemophilus influenzae PittEE 5225571 YP_001291495.1 CDS trkA NC_009566.1 1792239 1793615 R involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component complement(1792239..1793615) Haemophilus influenzae PittEE 5225572 YP_001291496.1 CDS trkA NC_009566.1 1793628 1794983 R COG0144 tRNA and rRNA cytosine-C5-methylases; potassium transporter peripheral membrane component complement(1793628..1794983) Haemophilus influenzae PittEE 5225573 YP_001291497.1 CDS fmt NC_009566.1 1794983 1795939 R modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase complement(1794983..1795939) Haemophilus influenzae PittEE 5225574 YP_001291498.1 CDS def NC_009566.1 1796033 1796542 R cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase complement(1796033..1796542) Haemophilus influenzae PittEE 5225575 YP_001291499.1 CDS CGSHiEE_09125 NC_009566.1 1796651 1797145 R hypothetical protein complement(1796651..1797145) Haemophilus influenzae PittEE 5225576 YP_001291500.1 CDS CGSHiEE_09130 NC_009566.1 1797155 1797616 R hypothetical protein complement(1797155..1797616) Haemophilus influenzae PittEE 5226147 YP_001291501.1 CDS CGSHiEE_09135 NC_009566.1 1797632 1797913 R hypothetical protein complement(1797632..1797913) Haemophilus influenzae PittEE 5226148 YP_001291503.1 CDS CGSHiEE_09145 NC_009566.1 1798026 1798289 R COG0242 N-formylmethionyl-tRNA deformylase; hypothetical protein complement(1798026..1798289) Haemophilus influenzae PittEE 5226150 YP_001291504.1 CDS def NC_009566.1 1804179 1804715 R COG3070 Regulator of competence-specific genes; peptide deformylase complement(1804179..1804715) Haemophilus influenzae PittEE 5224697 YP_001291505.1 CDS recA NC_009566.1 1805205 1806269 D catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1805205..1806269 Haemophilus influenzae PittEE 5225996 YP_001291506.1 CDS recX NC_009566.1 1806348 1806806 D binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1806348..1806806 Haemophilus influenzae PittEE 5225997 YP_001291507.1 CDS CGSHiEE_09165 NC_009566.1 1806803 1807189 R COG0239 Integral membrane protein possibly involved in chromosome condensation; camphor resistance protein CrcB complement(1806803..1807189) Haemophilus influenzae PittEE 5225998 YP_001291508.1 CDS CGSHiEE_09190 NC_009566.1 1809426 1810358 D reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 1809426..1810358 Haemophilus influenzae PittEE 5225999 YP_001291509.1 CDS CGSHiEE_09195 NC_009566.1 1810463 1811992 D COG1288 Predicted membrane protein; hypothetical protein 1810463..1811992 Haemophilus influenzae PittEE 5226000 CGSHiEE_t09342 tRNA CGSHiEE_t09342 NC_009566.1 146573 146658 R tRNA-Leu complement(146573..146658) Haemophilus influenzae PittEE 5542112 CGSHiEE_t09344 tRNA CGSHiEE_t09344 NC_009566.1 211332 211407 D tRNA-Lys 211332..211407 Haemophilus influenzae PittEE 5542109 CGSHiEE_t09346 tRNA CGSHiEE_t09346 NC_009566.1 211431 211506 D tRNA-Lys 211431..211506 Haemophilus influenzae PittEE 5542093 CGSHiEE_t09348 tRNA CGSHiEE_t09348 NC_009566.1 263735 263824 D tRNA-Ser 263735..263824 Haemophilus influenzae PittEE 5542117 CGSHiEE_t09350 tRNA CGSHiEE_t09350 NC_009566.1 314773 314848 R tRNA-Val complement(314773..314848) Haemophilus influenzae PittEE 5542115 CGSHiEE_t09352 tRNA CGSHiEE_t09352 NC_009566.1 314901 314976 R tRNA-Val complement(314901..314976) Haemophilus influenzae PittEE 5542103 CGSHiEE_t09354 tRNA CGSHiEE_t09354 NC_009566.1 315035 315110 R tRNA-Val complement(315035..315110) Haemophilus influenzae PittEE 5542099 CGSHiEE_t09356 tRNA CGSHiEE_t09356 NC_009566.1 315154 315229 R tRNA-Val complement(315154..315229) Haemophilus influenzae PittEE 5542097 CGSHiEE_t09358 tRNA CGSHiEE_t09358 NC_009566.1 316923 316998 D tRNA-Ala 316923..316998 Haemophilus influenzae PittEE 5542113 CGSHiEE_t09360 tRNA CGSHiEE_t09360 NC_009566.1 336292 336381 D tRNA-Ser 336292..336381 Haemophilus influenzae PittEE 5542118 CGSHiEE_t09362 tRNA CGSHiEE_t09362 NC_009566.1 378074 378149 D tRNA-Glu 378074..378149 Haemophilus influenzae PittEE 5542110 CGSHiEE_t09364 tRNA CGSHiEE_t09364 NC_009566.1 381938 382014 D tRNA-Asp 381938..382014 Haemophilus influenzae PittEE 5542122 CGSHiEE_t09366 tRNA CGSHiEE_t09366 NC_009566.1 382043 382118 D tRNA-Trp 382043..382118 Haemophilus influenzae PittEE 5542145 CGSHiEE_t09368 tRNA CGSHiEE_t09368 NC_009566.1 393538 393614 D tRNA-Pro 393538..393614 Haemophilus influenzae PittEE 5542101 CGSHiEE_t09370 tRNA CGSHiEE_t09370 NC_009566.1 393662 393738 D tRNA-Arg 393662..393738 Haemophilus influenzae PittEE 5542152 CGSHiEE_t09372 tRNA CGSHiEE_t09372 NC_009566.1 411218 411293 D tRNA-Glu 411218..411293 Haemophilus influenzae PittEE 5542137 CGSHiEE_t09374 tRNA CGSHiEE_t09374 NC_009566.1 513185 513261 D tRNA-Asp 513185..513261 Haemophilus influenzae PittEE 5542107 CGSHiEE_t09376 tRNA CGSHiEE_t09376 NC_009566.1 513285 513361 D tRNA-Asp 513285..513361 Haemophilus influenzae PittEE 5542133 CGSHiEE_t09378 tRNA CGSHiEE_t09378 NC_009566.1 521398 521473 R tRNA-Lys complement(521398..521473) Haemophilus influenzae PittEE 5542095 CGSHiEE_t09380 tRNA CGSHiEE_t09380 NC_009566.1 521524 521610 R tRNA-Leu complement(521524..521610) Haemophilus influenzae PittEE 5542132 CGSHiEE_t09382 tRNA CGSHiEE_t09382 NC_009566.1 521615 521690 R tRNA-Gly complement(521615..521690) Haemophilus influenzae PittEE 5542151 CGSHiEE_t09384 tRNA CGSHiEE_t09384 NC_009566.1 529620 529696 D tRNA-Met 529620..529696 Haemophilus influenzae PittEE 5542098 CGSHiEE_t09386 tRNA CGSHiEE_t09386 NC_009566.1 532111 532187 D tRNA-Arg 532111..532187 Haemophilus influenzae PittEE 5542105 CGSHiEE_t09388 tRNA CGSHiEE_t09388 NC_009566.1 532214 532289 D tRNA-His 532214..532289 Haemophilus influenzae PittEE 5542127 CGSHiEE_t09390 tRNA CGSHiEE_t09390 NC_009566.1 532311 532387 D tRNA-Pro 532311..532387 Haemophilus influenzae PittEE 5542134 CGSHiEE_t09392 tRNA CGSHiEE_t09392 NC_009566.1 534183 534259 D tRNA-Ile 534183..534259 Haemophilus influenzae PittEE 5542153 CGSHiEE_t09394 tRNA CGSHiEE_t09394 NC_009566.1 534345 534420 D tRNA-Ala 534345..534420 Haemophilus influenzae PittEE 5542143 CGSHiEE_t09396 tRNA CGSHiEE_t09396 NC_009566.1 575938 576013 R tRNA-Lys complement(575938..576013) Haemophilus influenzae PittEE 5542094 CGSHiEE_t09398 tRNA CGSHiEE_t09398 NC_009566.1 576064 576150 R tRNA-Leu complement(576064..576150) Haemophilus influenzae PittEE 5542130 CGSHiEE_t09400 tRNA CGSHiEE_t09400 NC_009566.1 576178 576251 R tRNA-Cys complement(576178..576251) Haemophilus influenzae PittEE 5542120 CGSHiEE_t09402 tRNA CGSHiEE_t09402 NC_009566.1 576258 576333 R tRNA-Gly complement(576258..576333) Haemophilus influenzae PittEE 5542129 CGSHiEE_t09404 tRNA CGSHiEE_t09404 NC_009566.1 620061 620150 R tRNA-Ser complement(620061..620150) Haemophilus influenzae PittEE 5542147 CGSHiEE_t09406 tRNA CGSHiEE_t09406 NC_009566.1 676923 676999 D tRNA-Ile 676923..676999 Haemophilus influenzae PittEE 5542149 CGSHiEE_t09408 tRNA CGSHiEE_t09408 NC_009566.1 677085 677160 D tRNA-Ala 677085..677160 Haemophilus influenzae PittEE 5542150 CGSHiEE_t09410 tRNA CGSHiEE_t09410 NC_009566.1 702662 702737 R tRNA-Gly complement(702662..702737) Haemophilus influenzae PittEE 5542100 CGSHiEE_t09412 tRNA CGSHiEE_t09412 NC_009566.1 702762 702837 R tRNA-Gly complement(702762..702837) Haemophilus influenzae PittEE 5542144 CGSHiEE_t09414 tRNA CGSHiEE_t09414 NC_009566.1 823150 823225 D tRNA-Asn 823150..823225 Haemophilus influenzae PittEE 5542140 CGSHiEE_t09416 tRNA CGSHiEE_t09416 NC_009566.1 855427 855503 D tRNA-Met 855427..855503 Haemophilus influenzae PittEE 5542146 CGSHiEE_t09418 tRNA CGSHiEE_t09418 NC_009566.1 967932 968017 R tRNA-Leu complement(967932..968017) Haemophilus influenzae PittEE 5542116 CGSHiEE_t09420 tRNA CGSHiEE_t09420 NC_009566.1 1089273 1089349 R tRNA-Val complement(1089273..1089349) Haemophilus influenzae PittEE 5542114 CGSHiEE_t09422 tRNA CGSHiEE_t09422 NC_009566.1 1157323 1157397 R tRNA-Gln complement(1157323..1157397) Haemophilus influenzae PittEE 5542104 CGSHiEE_t09424 tRNA CGSHiEE_t09424 NC_009566.1 1157445 1157519 R tRNA-Gln complement(1157445..1157519) Haemophilus influenzae PittEE 5542128 CGSHiEE_t09426 tRNA CGSHiEE_t09426 NC_009566.1 1157548 1157632 R tRNA-Leu complement(1157548..1157632) Haemophilus influenzae PittEE 5542138 CGSHiEE_t09428 tRNA CGSHiEE_t09428 NC_009566.1 1157638 1157714 R tRNA-Met complement(1157638..1157714) Haemophilus influenzae PittEE 5542131 CGSHiEE_t09430 tRNA CGSHiEE_t09430 NC_009566.1 1462617 1462693 D tRNA-Met 1462617..1462693 Haemophilus influenzae PittEE 5542102 CGSHiEE_t09432 tRNA CGSHiEE_t09432 NC_009566.1 1627845 1627920 R tRNA-Asn complement(1627845..1627920) Haemophilus influenzae PittEE 5542106 CGSHiEE_t09434 tRNA CGSHiEE_t09434 NC_009566.1 1627923 1627998 R tRNA-Phe complement(1627923..1627998) Haemophilus influenzae PittEE 5542124 CGSHiEE_t09436 tRNA CGSHiEE_t09436 NC_009566.1 1679624 1679699 R tRNA-Ala complement(1679624..1679699) Haemophilus influenzae PittEE 5542121 CGSHiEE_t09438 tRNA CGSHiEE_t09438 NC_009566.1 1679785 1679861 R tRNA-Ile complement(1679785..1679861) Haemophilus influenzae PittEE 5542135 CGSHiEE_t09440 tRNA CGSHiEE_t09440 NC_009566.1 1699571 1699665 D tRNA-Sec 1699571..1699665 Haemophilus influenzae PittEE 5542111 CGSHiEE_t09442 tRNA CGSHiEE_t09442 NC_009566.1 1777253 1777347 D tRNA-Ser 1777253..1777347 Haemophilus influenzae PittEE 5542096 CGSHiEE_t09444 tRNA CGSHiEE_t09444 NC_009566.1 1777368 1777444 D tRNA-Arg 1777368..1777444 Haemophilus influenzae PittEE 5542141 CGSHiEE_t09446 tRNA CGSHiEE_t09446 NC_009566.1 1777502 1777578 D tRNA-Arg 1777502..1777578 Haemophilus influenzae PittEE 5542119 CGSHiEE_t09448 tRNA CGSHiEE_t09448 NC_009566.1 1787499 1787574 R tRNA-Thr complement(1787499..1787574) Haemophilus influenzae PittEE 5542108 CGSHiEE_t09450 tRNA CGSHiEE_t09450 NC_009566.1 1787578 1787652 R tRNA-Gly complement(1787578..1787652) Haemophilus influenzae PittEE 5542148 CGSHiEE_t09452 tRNA CGSHiEE_t09452 NC_009566.1 1787695 1787779 R tRNA-Tyr complement(1787695..1787779) Haemophilus influenzae PittEE 5542139 CGSHiEE_t09454 tRNA CGSHiEE_t09454 NC_009566.1 1787809 1787884 R tRNA-Thr complement(1787809..1787884) Haemophilus influenzae PittEE 5542142 CGSHiEE_t09456 tRNA CGSHiEE_t09456 NC_009566.1 1802133 1802208 R tRNA-Glu complement(1802133..1802208) Haemophilus influenzae PittEE 5542123 CGSHiEE_r09322 rRNA CGSHiEE_r09322 NC_009566.1 376402 377942 D 16S ribosomal RNA 376402..377942 Haemophilus influenzae PittEE 5224764 CGSHiEE_r09334 rRNA CGSHiEE_r09334 NC_009566.1 378423 381416 D 23S ribosomal RNA 378423..381416 Haemophilus influenzae PittEE 5542154 CGSHiEE_r09310 rRNA CGSHiEE_r09310 NC_009566.1 381644 381763 D 5S ribosomal RNA 381644..381763 Haemophilus influenzae PittEE 5224765 CGSHiEE_r09324 rRNA CGSHiEE_r09324 NC_009566.1 409546 411086 D 16S ribosomal RNA 409546..411086 Haemophilus influenzae PittEE 5225036 CGSHiEE_r09336 rRNA CGSHiEE_r09336 NC_009566.1 411564 414564 D 23S ribosomal RNA 411564..414564 Haemophilus influenzae PittEE 5542126 CGSHiEE_r09312 rRNA CGSHiEE_r09312 NC_009566.1 414756 414875 D 5S ribosomal RNA 414756..414875 Haemophilus influenzae PittEE 5225037 CGSHiEE_r09326 rRNA CGSHiEE_r09326 NC_009566.1 532564 534103 D 16S ribosomal RNA 532564..534103 Haemophilus influenzae PittEE 5224793 CGSHiEE_r09338 rRNA CGSHiEE_r09338 NC_009566.1 534829 537935 D 23S ribosomal RNA join(534829..536104,536197..537935) Haemophilus influenzae PittEE 5291005 CGSHiEE_r09314 rRNA CGSHiEE_r09314 NC_009566.1 538131 538250 D 5S ribosomal RNA 538131..538250 Haemophilus influenzae PittEE 5225978 CGSHiEE_r09328 rRNA CGSHiEE_r09328 NC_009566.1 675304 676843 D 16S ribosomal RNA 675304..676843 Haemophilus influenzae PittEE 5225159 CGSHiEE_r09340 rRNA CGSHiEE_r09340 NC_009566.1 677569 680675 D 23S ribosomal RNA join(677569..678846,678937..680675) Haemophilus influenzae PittEE 5291007 CGSHiEE_r09316 rRNA CGSHiEE_r09316 NC_009566.1 680920 681038 D 5S ribosomal RNA 680920..681038 Haemophilus influenzae PittEE 5225160 CGSHiEE_r09318 rRNA CGSHiEE_r09318 NC_009566.1 1675760 1675879 R 5S ribosomal RNA complement(1675760..1675879) Haemophilus influenzae PittEE 5225891 CGSHiEE_r09342 rRNA CGSHiEE_r09342 NC_009566.1 1676108 1679215 R 23S ribosomal RNA complement(join(1676108..1677847,1677938..1679215)) Haemophilus influenzae PittEE 5542125 CGSHiEE_r09330 rRNA CGSHiEE_r09330 NC_009566.1 1679941 1681480 R 16S ribosomal RNA complement(1679941..1681480) Haemophilus influenzae PittEE 5225892 CGSHiEE_r09320 rRNA CGSHiEE_r09320 NC_009566.1 1798519 1798638 R 5S ribosomal RNA complement(1798519..1798638) Haemophilus influenzae PittEE 5226151 CGSHiEE_r09344 rRNA CGSHiEE_r09344 NC_009566.1 1798862 1801208 R 23S ribosomal RNA complement(1798862..1801208) Haemophilus influenzae PittEE 5542136 CGSHiEE_r09344 rRNA CGSHiEE_r09344 NC_009566.1 1801321 1801862 R 23S ribosomal RNA complement(1801321..1801862) Haemophilus influenzae PittEE 5542136 CGSHiEE_r09332 rRNA CGSHiEE_r09332 NC_009566.1 1802340 1803880 R 16S ribosomal RNA complement(1802340..1803880) Haemophilus influenzae PittEE 5226152