-- dump date 20140619_104341 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_001289887.1 148825134 5226334 1450..4413 1 NC_009566.1 COG1629 Outer membrane receptor proteins, mostly Fe transport; hemoglobin-haptoglobin binding protein B 4413 5226334 CGSHiEE_00010 Haemophilus influenzae PittEE hemoglobin-haptoglobin binding protein B YP_001289887.1 1450 D 374930 CDS YP_001289888.1 148825135 5225155 6964..8235 1 NC_009566.1 COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; peptidase E 8235 5225155 CGSHiEE_00035 Haemophilus influenzae PittEE peptidase E YP_001289888.1 6964 D 374930 CDS YP_001289889.1 148825136 5225149 8329..10302 1 NC_009566.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein 10302 cpdB 5225149 cpdB Haemophilus influenzae PittEE bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein YP_001289889.1 8329 D 374930 CDS YP_001289890.1 148825137 5225200 complement(10568..11047) 1 NC_009566.1 COG0500 SAM-dependent methyltransferases; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein 11047 cpdB 5225200 cpdB Haemophilus influenzae PittEE bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein YP_001289890.1 10568 R 374930 CDS YP_001289891.1 148825138 5225201 11499..13388 1 NC_009566.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 13388 5225201 CGSHiEE_00050 Haemophilus influenzae PittEE tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA YP_001289891.1 11499 D 374930 CDS YP_001289892.1 148825139 5225202 13570..13944 1 NC_009566.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 13944 rpsL 5225202 rpsL Haemophilus influenzae PittEE 30S ribosomal protein S12 YP_001289892.1 13570 D 374930 CDS YP_001289893.1 148825140 5225183 14102..14572 1 NC_009566.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 14572 5225183 CGSHiEE_00060 Haemophilus influenzae PittEE 30S ribosomal protein S7 YP_001289893.1 14102 D 374930 CDS YP_001289894.1 148825141 5225184 14656..16758 1 NC_009566.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 16758 5225184 CGSHiEE_00065 Haemophilus influenzae PittEE elongation factor G YP_001289894.1 14656 D 374930 CDS YP_001289895.1 148825142 5225185 16823..18007 1 NC_009566.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 18007 5225185 CGSHiEE_00070 Haemophilus influenzae PittEE elongation factor Tu YP_001289895.1 16823 D 374930 CDS YP_001289896.1 148825143 5225186 complement(18137..18424) 1 NC_009566.1 COG2168 Uncharacterized conserved protein involved in oxidation of intracellular sulfur; elongation factor G 18424 5225186 CGSHiEE_00075 Haemophilus influenzae PittEE elongation factor G YP_001289896.1 18137 R 374930 CDS YP_001289897.1 148825144 5225187 complement(18433..18792) 1 NC_009566.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC 18792 5225187 CGSHiEE_00080 Haemophilus influenzae PittEE sulfur relay protein TusC YP_001289897.1 18433 R 374930 CDS YP_001289898.1 148825145 5224905 complement(18789..19169) 1 NC_009566.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 19169 5224905 CGSHiEE_00085 Haemophilus influenzae PittEE sulfur transfer complex subunit TusD YP_001289898.1 18789 R 374930 CDS YP_001289899.1 148825146 5224906 complement(19169..19834) 1 NC_009566.1 COG2964 Uncharacterized protein conserved in bacteria; hypothetical protein 19834 5224906 CGSHiEE_00090 Haemophilus influenzae PittEE hypothetical protein YP_001289899.1 19169 R 374930 CDS YP_001289900.1 148825147 5224907 complement(19924..20649) 1 NC_009566.1 COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1; hypothetical protein 20649 5224907 CGSHiEE_00095 Haemophilus influenzae PittEE hypothetical protein YP_001289900.1 19924 R 374930 CDS YP_001289901.1 148825148 5224908 20747..20968 1 NC_009566.1 COG2900 Uncharacterized protein conserved in bacteria; hypothetical protein 20968 5224908 CGSHiEE_00100 Haemophilus influenzae PittEE hypothetical protein YP_001289901.1 20747 D 374930 CDS YP_001289902.1 148825149 5224909 complement(21060..21785) 1 NC_009566.1 COG0678 Peroxiredoxin; hypothetical protein 21785 5224909 CGSHiEE_00105 Haemophilus influenzae PittEE hypothetical protein YP_001289902.1 21060 R 374930 CDS YP_001289903.1 148825150 5226279 21909..22814 1 NC_009566.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 22814 5226279 CGSHiEE_00110 Haemophilus influenzae PittEE DNA-binding transcriptional regulator OxyR YP_001289903.1 21909 D 374930 CDS YP_001289904.1 148825151 5226280 22814..23431 1 NC_009566.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 23431 5226280 CGSHiEE_00115 Haemophilus influenzae PittEE DNA-binding transcriptional repressor FabR YP_001289904.1 22814 D 374930 CDS YP_001289905.1 148825152 5226281 complement(23501..23977) 1 NC_009566.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 23977 greB 5226281 greB Haemophilus influenzae PittEE transcription elongation factor GreB YP_001289905.1 23501 R 374930 CDS YP_001289906.1 148825153 5226282 24073..26385 1 NC_009566.1 COG2183 Transcriptional accessory protein; transcription elongation factor GreB 26385 greB 5226282 greB Haemophilus influenzae PittEE transcription elongation factor GreB YP_001289906.1 24073 D 374930 CDS YP_001289907.1 148825154 5226283 26511..28931 1 NC_009566.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 28931 gyrB 5226283 gyrB Haemophilus influenzae PittEE DNA gyrase subunit B YP_001289907.1 26511 D 374930 CDS YP_001289908.1 148825155 5226284 29078..29752 1 NC_009566.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 29752 5226284 CGSHiEE_00135 Haemophilus influenzae PittEE ribulose-phosphate 3-epimerase YP_001289908.1 29078 D 374930 CDS YP_001289909.1 148825156 5224727 29798..30472 1 NC_009566.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 30472 5224727 CGSHiEE_00140 Haemophilus influenzae PittEE phosphoglycolate phosphatase YP_001289909.1 29798 D 374930 CDS YP_001289910.1 148825157 5224728 30563..30916 1 NC_009566.1 transposase 30916 5224728 CGSHiEE_00145 Haemophilus influenzae PittEE transposase YP_001289910.1 30563 D 374930 CDS YP_001289911.1 148825158 5224729 31084..31200 1 NC_009566.1 COG2963 Transposase and inactivated derivatives; hypothetical protein 31200 5224729 CGSHiEE_00150 Haemophilus influenzae PittEE hypothetical protein YP_001289911.1 31084 D 374930 CDS YP_001289912.1 148825159 5224730 31113..31352 1 NC_009566.1 COG2801 Transposase and inactivated derivatives; ribulose-phosphate 3-epimerase 31352 5224730 CGSHiEE_00155 Haemophilus influenzae PittEE ribulose-phosphate 3-epimerase YP_001289912.1 31113 D 374930 CDS YP_001289913.1 148825160 5224731 complement(31415..32407) 1 NC_009566.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 32407 5224731 CGSHiEE_00160 Haemophilus influenzae PittEE asparagine synthetase AsnA YP_001289913.1 31415 R 374930 CDS YP_001289914.1 148825161 5225114 32561..33013 1 NC_009566.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 33013 5225114 CGSHiEE_00165 Haemophilus influenzae PittEE DNA-binding transcriptional regulator AsnC YP_001289914.1 32561 D 374930 CDS YP_001289915.1 148825162 5225115 complement(33039..33434) 1 NC_009566.1 COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog); hypothetical protein 33434 5225115 CGSHiEE_00170 Haemophilus influenzae PittEE hypothetical protein YP_001289915.1 33039 R 374930 CDS YP_001289916.1 148825163 5225116 33666..35654 1 NC_009566.1 COG1297 Predicted membrane protein; hypothetical protein 35654 5225116 CGSHiEE_00175 Haemophilus influenzae PittEE hypothetical protein YP_001289916.1 33666 D 374930 CDS YP_001289917.1 148825164 5225117 35707..36123 1 NC_009566.1 COG1175 ABC-type sugar transport systems, permease components; hypothetical protein 36123 5225117 CGSHiEE_00180 Haemophilus influenzae PittEE hypothetical protein YP_001289917.1 35707 D 374930 CDS YP_001289918.1 148825165 5225118 36128..36937 1 NC_009566.1 COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase; DNA-binding transcriptional regulator AsnC 36937 5225118 CGSHiEE_00185 Haemophilus influenzae PittEE DNA-binding transcriptional regulator AsnC YP_001289918.1 36128 D 374930 CDS YP_001289919.1 148825166 5225119 37013..38497 1 NC_009566.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 38497 5225119 CGSHiEE_00190 Haemophilus influenzae PittEE glucose-6-phosphate 1-dehydrogenase YP_001289919.1 37013 D 374930 CDS YP_001289920.1 148825167 5225209 38582..39280 1 NC_009566.1 COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase; 6-phosphogluconolactonase 39280 5225209 CGSHiEE_00195 Haemophilus influenzae PittEE 6-phosphogluconolactonase YP_001289920.1 38582 D 374930 CDS YP_001289921.1 148825168 5225210 39291..39737 1 NC_009566.1 virulence-associated protein D 39737 5225210 CGSHiEE_00200 Haemophilus influenzae PittEE virulence-associated protein D YP_001289921.1 39291 D 374930 CDS YP_001289922.1 148825169 5225211 39885..40667 1 NC_009566.1 COG3309 Uncharacterized virulence-associated protein D; glucose-6-phosphate 1-dehydrogenase 40667 5225211 CGSHiEE_00205 Haemophilus influenzae PittEE glucose-6-phosphate 1-dehydrogenase YP_001289922.1 39885 D 374930 CDS YP_001289923.1 148825170 5225212 40687..42141 1 NC_009566.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 42141 5225212 CGSHiEE_00210 Haemophilus influenzae PittEE 6-phosphogluconate dehydrogenase YP_001289923.1 40687 D 374930 CDS YP_001289924.1 148825171 5225213 complement(42267..42890) 1 NC_009566.1 COG0362 6-phosphogluconate dehydrogenase; 6-phosphogluconate dehydrogenase 42890 5225213 CGSHiEE_00215 Haemophilus influenzae PittEE 6-phosphogluconate dehydrogenase YP_001289924.1 42267 R 374930 CDS YP_001289925.1 148825172 5225228 complement(42900..43727) 1 NC_009566.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 43727 apaH 5225228 apaH Haemophilus influenzae PittEE diadenosine tetraphosphatase YP_001289925.1 42900 R 374930 CDS YP_001289926.1 148825173 5225229 43846..44754 1 NC_009566.1 COG3306 Glycosyltransferase involved in LPS biosynthesis; diadenosine tetraphosphatase 44754 apaH 5225229 apaH Haemophilus influenzae PittEE diadenosine tetraphosphatase YP_001289926.1 43846 D 374930 CDS YP_001289927.1 148825174 5225230 complement(44793..45656) 1 NC_009566.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 45656 ksgA 5225230 ksgA Haemophilus influenzae PittEE dimethyladenosine transferase YP_001289927.1 44793 R 374930 CDS YP_001289928.1 148825175 5225231 complement(45740..46735) 1 NC_009566.1 COG0438 Glycosyltransferase; lipooligosaccharide glycosyl transferase G 46735 5225231 CGSHiEE_00235 Haemophilus influenzae PittEE lipooligosaccharide glycosyl transferase G YP_001289928.1 45740 R 374930 CDS YP_001289929.1 148825176 5225232 complement(46823..47659) 1 NC_009566.1 COG3306 Glycosyltransferase involved in LPS biosynthesis; dimethyladenosine transferase 47659 ksgA 5225232 ksgA Haemophilus influenzae PittEE dimethyladenosine transferase YP_001289929.1 46823 R 374930 CDS YP_001289930.1 148825177 5225233 47795..48013 1 NC_009566.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 48013 infA 5225233 infA Haemophilus influenzae PittEE translation initiation factor IF-1 YP_001289930.1 47795 D 374930 CDS YP_001289931.1 148825178 5226182 complement(48010..48135) 1 NC_009566.1 COG0361 Translation initiation factor 1 (IF-1); hypothetical protein 48135 5226182 CGSHiEE_00250 Haemophilus influenzae PittEE hypothetical protein YP_001289931.1 48010 R 374930 CDS YP_001289932.1 148825179 5226183 48212..48589 1 NC_009566.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 48589 rpsF 5226183 rpsF Haemophilus influenzae PittEE 30S ribosomal protein S6 YP_001289932.1 48212 D 374930 CDS YP_001289933.1 148825180 5226184 48576..48902 1 NC_009566.1 binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 48902 5226184 CGSHiEE_00260 Haemophilus influenzae PittEE primosomal replication protein N YP_001289933.1 48576 D 374930 CDS YP_001289934.1 148825181 5226185 48915..49142 1 NC_009566.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 49142 rpsR 5226185 rpsR Haemophilus influenzae PittEE 30S ribosomal protein S18 YP_001289934.1 48915 D 374930 CDS YP_001289935.1 148825182 5226186 49159..49608 1 NC_009566.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 49608 rplI 5226186 rplI Haemophilus influenzae PittEE 50S ribosomal protein L9 YP_001289935.1 49159 D 374930 CDS YP_001289936.1 148825183 5225427 complement(49782..51428) 1 NC_009566.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 51428 groEL 5225427 groEL Haemophilus influenzae PittEE chaperonin GroEL YP_001289936.1 49782 R 374930 CDS YP_001289937.1 148825184 5225428 complement(51451..51741) 1 NC_009566.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 51741 groES 5225428 groES Haemophilus influenzae PittEE co-chaperonin GroES YP_001289937.1 51451 R 374930 CDS YP_001289938.1 148825185 5225429 51907..52209 1 NC_009566.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 52209 ureA 5225429 ureA Haemophilus influenzae PittEE urease subunit gamma YP_001289938.1 51907 D 374930 CDS YP_001289939.1 148825186 5225430 52286..52591 1 NC_009566.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active; urease subunit beta 52591 ureB 5225430 ureB Haemophilus influenzae PittEE urease subunit beta YP_001289939.1 52286 D 374930 CDS YP_001289940.1 148825187 5225431 52603..54321 1 NC_009566.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 54321 ureC 5225431 ureC Haemophilus influenzae PittEE urease subunit alpha YP_001289940.1 52603 D 374930 CDS YP_001289941.1 148825188 5225432 54449..55006 1 NC_009566.1 involved in the assembly of the urease metallocenter; possible nickel donor; urease accessory protein UreE 55006 ureE 5225432 ureE Haemophilus influenzae PittEE urease accessory protein UreE YP_001289941.1 54449 D 374930 CDS YP_001289942.1 148825189 5225083 54991..55698 1 NC_009566.1 COG0830 Urease accessory protein UreF; urease accessory protein UreF 55698 5225083 CGSHiEE_00305 Haemophilus influenzae PittEE urease accessory protein UreF YP_001289942.1 54991 D 374930 CDS YP_001289943.1 148825190 5225084 55843..56478 1 NC_009566.1 COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; urease accessory protein 56478 5225084 CGSHiEE_00310 Haemophilus influenzae PittEE urease accessory protein YP_001289943.1 55843 D 374930 CDS YP_001289944.1 148825191 5225085 56551..57366 1 NC_009566.1 COG0829 Urease accessory protein UreH; co-chaperonin GroES 57366 groES 5225085 groES Haemophilus influenzae PittEE co-chaperonin GroES YP_001289944.1 56551 D 374930 CDS YP_001289945.1 148825192 5225086 57522..58940 1 NC_009566.1 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 58940 aspA 5225086 aspA Haemophilus influenzae PittEE aspartate ammonia-lyase YP_001289945.1 57522 D 374930 CDS YP_001289946.1 148825193 5225087 complement(59244..61181) 1 NC_009566.1 COG0568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32); aspartate ammonia-lyase 61181 aspA 5225087 aspA Haemophilus influenzae PittEE aspartate ammonia-lyase YP_001289946.1 59244 R 374930 CDS YP_001289947.1 148825194 5225056 complement(61184..62965) 1 NC_009566.1 synthesizes RNA primers at the replication forks; DNA primase 62965 dnaG 5225056 dnaG Haemophilus influenzae PittEE DNA primase YP_001289947.1 61184 R 374930 CDS YP_001289948.1 148825195 5225057 complement(63099..63314) 1 NC_009566.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 63314 rpsU 5225057 rpsU Haemophilus influenzae PittEE 30S ribosomal protein S21 YP_001289948.1 63099 R 374930 CDS YP_001289949.1 148825196 5225058 63546..64574 1 NC_009566.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 64574 5225058 CGSHiEE_00340 Haemophilus influenzae PittEE putative DNA-binding/iron metalloprotein/AP endonuclease YP_001289949.1 63546 D 374930 CDS YP_001289950.1 148825197 5225059 64583..65164 1 NC_009566.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 65164 5225059 CGSHiEE_00345 Haemophilus influenzae PittEE thymidine kinase YP_001289950.1 64583 D 374930 CDS YP_001289951.1 148825198 5225060 65201..66421 1 NC_009566.1 COG0814 Amino acid permeases; tyrosine-specific transport protein 2 66421 5225060 CGSHiEE_00350 Haemophilus influenzae PittEE tyrosine-specific transport protein 2 YP_001289951.1 65201 D 374930 CDS YP_001289952.1 148825199 5225061 complement(66559..66819) 1 NC_009566.1 COG1145 Ferredoxin; putative ferredoxin-like protein 66819 5225061 CGSHiEE_00355 Haemophilus influenzae PittEE putative ferredoxin-like protein YP_001289952.1 66559 R 374930 CDS YP_001289953.1 148825200 5225021 67132..67680 1 NC_009566.1 COG3719 Ribonuclease I; thymidine kinase 67680 5225021 CGSHiEE_00360 Haemophilus influenzae PittEE thymidine kinase YP_001289953.1 67132 D 374930 CDS YP_001289954.1 148825201 5225022 67776..68936 1 NC_009566.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 68936 pgk 5225022 pgk Haemophilus influenzae PittEE phosphoglycerate kinase YP_001289954.1 67776 D 374930 CDS YP_001289955.1 148825202 5225023 69047..70126 1 NC_009566.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 70126 5225023 CGSHiEE_00370 Haemophilus influenzae PittEE fructose-bisphosphate aldolase YP_001289955.1 69047 D 374930 CDS YP_001289956.1 148825203 5225024 72066..73610 1 NC_009566.1 COG1882 Pyruvate-formate lyase; hypothetical protein 73610 5225024 CGSHiEE_00395 Haemophilus influenzae PittEE hypothetical protein YP_001289956.1 72066 D 374930 CDS YP_001289957.1 148825204 5225003 73619..74407 1 NC_009566.1 COG1180 Pyruvate-formate lyase-activating enzyme; hypothetical protein 74407 5225003 CGSHiEE_00400 Haemophilus influenzae PittEE hypothetical protein YP_001289957.1 73619 D 374930 CDS YP_001289958.1 148825205 5225004 74506..75759 1 NC_009566.1 COG1972 Nucleoside permease; hypothetical protein 75759 5225004 CGSHiEE_00405 Haemophilus influenzae PittEE hypothetical protein YP_001289958.1 74506 D 374930 CDS YP_001289959.1 148825206 5225005 75833..76549 1 NC_009566.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 76549 deoD 5225005 deoD Haemophilus influenzae PittEE purine nucleoside phosphorylase YP_001289959.1 75833 D 374930 CDS YP_001289960.1 148825207 5225006 76720..77148 1 NC_009566.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 77148 rplK 5225006 rplK Haemophilus influenzae PittEE 50S ribosomal protein L11 YP_001289960.1 76720 D 374930 CDS YP_001289961.1 148825208 5225007 77153..77842 1 NC_009566.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 77842 rplA 5225007 rplA Haemophilus influenzae PittEE 50S ribosomal protein L1 YP_001289961.1 77153 D 374930 CDS YP_001289962.1 148825209 5224920 78222..82253 1 NC_009566.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 82253 rpoB 5224920 rpoB Haemophilus influenzae PittEE DNA-directed RNA polymerase subunit beta YP_001289962.1 78222 D 374930 CDS YP_001289963.1 148825210 5224921 82391..86641 1 NC_009566.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 86641 5224921 CGSHiEE_00430 Haemophilus influenzae PittEE DNA-directed RNA polymerase subunit beta' YP_001289963.1 82391 D 374930 CDS YP_001289964.1 148825211 5224922 86836..87780 1 NC_009566.1 COG1275 Tellurite resistance protein and related permeases; potassium-tellurite ethidium and proflavin transporter 87780 5224922 CGSHiEE_00435 Haemophilus influenzae PittEE potassium-tellurite ethidium and proflavin transporter YP_001289964.1 86836 D 374930 CDS YP_001289965.1 148825212 5224923 complement(87835..88554) 1 NC_009566.1 COG1720 Uncharacterized conserved protein; potassium-tellurite ethidium and proflavin transporter 88554 5224923 CGSHiEE_00440 Haemophilus influenzae PittEE potassium-tellurite ethidium and proflavin transporter YP_001289965.1 87835 R 374930 CDS YP_001289966.1 148825213 5224924 88616..89527 1 NC_009566.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 89527 5224924 CGSHiEE_00445 Haemophilus influenzae PittEE 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_001289966.1 88616 D 374930 CDS YP_001289967.1 148825214 5224925 89578..90066 1 NC_009566.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 90066 5224925 CGSHiEE_00450 Haemophilus influenzae PittEE ribonuclease activity regulator protein RraA YP_001289967.1 89578 D 374930 CDS YP_001289968.1 148825215 5224884 complement(90201..90752) 1 NC_009566.1 COG2862 Predicted membrane protein; hypothetical protein 90752 5224884 CGSHiEE_00455 Haemophilus influenzae PittEE hypothetical protein YP_001289968.1 90201 R 374930 CDS YP_001289969.1 148825216 5224885 complement(90860..91858) 1 NC_009566.1 COG1609 Transcriptional regulators; hypothetical protein 91858 5224885 CGSHiEE_00460 Haemophilus influenzae PittEE hypothetical protein YP_001289969.1 90860 R 374930 CDS YP_001289970.1 148825217 5224886 complement(91885..92805) 1 NC_009566.1 catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 92805 5224886 CGSHiEE_00465 Haemophilus influenzae PittEE ribokinase YP_001289970.1 91885 R 374930 CDS YP_001289971.1 148825218 5224887 complement(92903..93781) 1 NC_009566.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 93781 5224887 CGSHiEE_00470 Haemophilus influenzae PittEE D-ribose transporter subunit RbsB YP_001289971.1 92903 R 374930 CDS YP_001289972.1 148825219 5224888 complement(93801..94769) 1 NC_009566.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease protein 94769 rbsC 5224888 rbsC Haemophilus influenzae PittEE ribose ABC transporter permease protein YP_001289972.1 93801 R 374930 CDS YP_001289973.1 148825220 5224878 complement(94785..96266) 1 NC_009566.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP binding protein 96266 5224878 CGSHiEE_00480 Haemophilus influenzae PittEE D-ribose transporter ATP binding protein YP_001289973.1 94785 R 374930 CDS YP_001289974.1 148825221 5224879 complement(96280..96699) 1 NC_009566.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 96699 5224879 CGSHiEE_00485 Haemophilus influenzae PittEE D-ribose pyranase YP_001289974.1 96280 R 374930 CDS YP_001289975.1 148825222 5224880 complement(96863..98305) 1 NC_009566.1 COG1322 Uncharacterized protein conserved in bacteria; DNA recombination protein RmuC 98305 5224880 CGSHiEE_00490 Haemophilus influenzae PittEE DNA recombination protein RmuC YP_001289975.1 96863 R 374930 CDS YP_001289976.1 148825223 5224881 complement(98470..99660) 1 NC_009566.1 COG0665 Glycine/D-amino acid oxidases (deaminating); oxidoreductase OrdL 99660 5224881 CGSHiEE_00495 Haemophilus influenzae PittEE oxidoreductase OrdL YP_001289976.1 98470 R 374930 CDS YP_001289977.1 148825224 5224882 complement(99582..99764) 1 NC_009566.1 COG0665 Glycine/D-amino acid oxidases (deaminating); oxidoreductase OrdL 99764 5224882 CGSHiEE_00500 Haemophilus influenzae PittEE oxidoreductase OrdL YP_001289977.1 99582 R 374930 CDS YP_001289978.1 148825225 5224883 99904..100956 1 NC_009566.1 COG0687 Spermidine/putrescine-binding periplasmic protein; cytoplasmic sugar-binding protein 100956 5224883 CGSHiEE_00505 Haemophilus influenzae PittEE cytoplasmic sugar-binding protein YP_001289978.1 99904 D 374930 CDS YP_001289979.1 148825226 5224873 complement(101026..102360) 1 NC_009566.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 102360 hslU 5224873 hslU Haemophilus influenzae PittEE ATP-dependent protease ATP-binding subunit HslU YP_001289979.1 101026 R 374930 CDS YP_001289980.1 148825227 5224874 complement(102371..102898) 1 NC_009566.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 102898 5224874 CGSHiEE_00515 Haemophilus influenzae PittEE ATP-dependent protease peptidase subunit YP_001289980.1 102371 R 374930 CDS YP_001289981.1 148825228 5224875 103118..103825 1 NC_009566.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 103825 aphA 5224875 aphA Haemophilus influenzae PittEE acid phosphatase/phosphotransferase YP_001289981.1 103118 D 374930 CDS YP_001289982.1 148825229 5224876 complement(103916..104227) 1 NC_009566.1 COG2801 Transposase and inactivated derivatives; acid phosphatase/phosphotransferase 104227 aphA 5224876 aphA Haemophilus influenzae PittEE acid phosphatase/phosphotransferase YP_001289982.1 103916 R 374930 CDS YP_001289983.1 148825230 5224877 complement(104744..105247) 1 NC_009566.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 105247 5224877 CGSHiEE_00530 Haemophilus influenzae PittEE S-ribosylhomocysteinase YP_001289983.1 104744 R 374930 CDS YP_001289984.1 148825231 5225182 complement(105432..105848) 1 NC_009566.1 COG1238 Predicted membrane protein; hypothetical protein 105848 5225182 CGSHiEE_00535 Haemophilus influenzae PittEE hypothetical protein YP_001289984.1 105432 R 374930 CDS YP_001289985.1 148825232 5224868 complement(105906..106508) 1 NC_009566.1 putative phosphatase/phosphohexomutase 106508 5224868 CGSHiEE_00540 Haemophilus influenzae PittEE putative phosphatase/phosphohexomutase YP_001289985.1 105906 R 374930 CDS YP_001289986.1 148825233 5224869 106624..107001 1 NC_009566.1 COG0637 Predicted phosphatase/phosphohexomutase; hypothetical protein 107001 5224869 CGSHiEE_00545 Haemophilus influenzae PittEE hypothetical protein YP_001289986.1 106624 D 374930 CDS YP_001289987.1 148825234 5224870 107141..107752 1 NC_009566.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 107752 gidB 5224870 gidB Haemophilus influenzae PittEE 16S rRNA methyltransferase GidB YP_001289987.1 107141 D 374930 CDS YP_001289988.1 148825235 5224871 107871..108245 1 NC_009566.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I 108245 5224871 CGSHiEE_00555 Haemophilus influenzae PittEE F0F1 ATP synthase subunit I YP_001289988.1 107871 D 374930 CDS YP_001289989.1 148825236 5224872 108273..109061 1 NC_009566.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 109061 5224872 CGSHiEE_00560 Haemophilus influenzae PittEE F0F1 ATP synthase subunit A YP_001289989.1 108273 D 374930 CDS YP_001289990.1 148825237 5224862 109117..109371 1 NC_009566.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 109371 5224862 CGSHiEE_00565 Haemophilus influenzae PittEE F0F1 ATP synthase subunit C YP_001289990.1 109117 D 374930 CDS YP_001289991.1 148825238 5224863 109421..109891 1 NC_009566.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 109891 5224863 CGSHiEE_00570 Haemophilus influenzae PittEE F0F1 ATP synthase subunit B YP_001289991.1 109421 D 374930 CDS YP_001289992.1 148825239 5224864 109904..110437 1 NC_009566.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 110437 5224864 CGSHiEE_00575 Haemophilus influenzae PittEE F0F1 ATP synthase subunit delta YP_001289992.1 109904 D 374930 CDS YP_001289993.1 148825240 5224865 110450..111991 1 NC_009566.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 111991 5224865 CGSHiEE_00580 Haemophilus influenzae PittEE F0F1 ATP synthase subunit alpha YP_001289993.1 110450 D 374930 CDS YP_001289994.1 148825241 5224866 112007..112876 1 NC_009566.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 112876 5224866 CGSHiEE_00585 Haemophilus influenzae PittEE F0F1 ATP synthase subunit gamma YP_001289994.1 112007 D 374930 CDS YP_001289995.1 148825242 5224851 112893..114266 1 NC_009566.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 114266 5224851 CGSHiEE_00590 Haemophilus influenzae PittEE F0F1 ATP synthase subunit beta YP_001289995.1 112893 D 374930 CDS YP_001289996.1 148825243 5224852 114296..114724 1 NC_009566.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 114724 atpC 5224852 atpC Haemophilus influenzae PittEE F0F1 ATP synthase subunit epsilon YP_001289996.1 114296 D 374930 CDS YP_001289997.1 148825244 5224853 complement(114910..116112) 1 NC_009566.1 tyrosine-specific transport protein 1 116112 5224853 CGSHiEE_00600 Haemophilus influenzae PittEE tyrosine-specific transport protein 1 YP_001289997.1 114910 R 374930 CDS YP_001289998.1 148825245 5224854 complement(116142..116294) 1 NC_009566.1 COG0814 Amino acid permeases; hypothetical protein 116294 5224854 CGSHiEE_00605 Haemophilus influenzae PittEE hypothetical protein YP_001289998.1 116142 R 374930 CDS YP_001289999.1 148825246 5224855 complement(117040..117816) 1 NC_009566.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 117816 5224855 CGSHiEE_00620 Haemophilus influenzae PittEE imidazole glycerol phosphate synthase subunit HisF YP_001289999.1 117040 R 374930 CDS YP_001290000.1 148825247 5224767 complement(117798..118547) 1 NC_009566.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 118547 5224767 CGSHiEE_00625 Haemophilus influenzae PittEE 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase YP_001290000.1 117798 R 374930 CDS YP_001290001.1 148825248 5224768 complement(118583..119182) 1 NC_009566.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 119182 hisH 5224768 hisH Haemophilus influenzae PittEE imidazole glycerol phosphate synthase subunit HisH YP_001290001.1 118583 R 374930 CDS YP_001290002.1 148825249 5224769 complement(119248..120336) 1 NC_009566.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 120336 5224769 CGSHiEE_00635 Haemophilus influenzae PittEE imidazole glycerol-phosphate dehydratase/histidinol phosphatase YP_001290002.1 119248 R 374930 CDS YP_001290003.1 148825250 5224770 complement(120448..121506) 1 NC_009566.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 121506 5224770 CGSHiEE_00640 Haemophilus influenzae PittEE histidinol-phosphate aminotransferase YP_001290003.1 120448 R 374930 CDS YP_001290004.1 148825251 5224771 complement(121620..122903) 1 NC_009566.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 122903 hisD 5224771 hisD Haemophilus influenzae PittEE histidinol dehydrogenase YP_001290004.1 121620 R 374930 CDS YP_001290005.1 148825252 5224772 complement(122996..123907) 1 NC_009566.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 123907 hisG 5224772 hisG Haemophilus influenzae PittEE ATP phosphoribosyltransferase YP_001290005.1 122996 R 374930 CDS YP_001290006.1 148825253 5224722 124356..125219 1 NC_009566.1 COG1561 Uncharacterized stress-induced protein; hypothetical protein 125219 5224722 CGSHiEE_00655 Haemophilus influenzae PittEE hypothetical protein YP_001290006.1 124356 D 374930 CDS YP_001290007.1 148825254 5224723 125229..126071 1 NC_009566.1 COG0354 Predicted aminomethyltransferase related to GcvT; hypothetical protein 126071 5224723 CGSHiEE_00660 Haemophilus influenzae PittEE hypothetical protein YP_001290007.1 125229 D 374930 CDS YP_001290008.1 148825255 5224724 complement(126115..127347) 1 NC_009566.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 127347 5224724 CGSHiEE_00665 Haemophilus influenzae PittEE D-3-phosphoglycerate dehydrogenase YP_001290008.1 126115 R 374930 CDS YP_001290009.1 148825256 5224725 complement(127377..128036) 1 NC_009566.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 128036 5224725 CGSHiEE_00670 Haemophilus influenzae PittEE ribose-5-phosphate isomerase A YP_001290009.1 127377 R 374930 CDS YP_001290010.1 148825257 5224726 complement(128170..129099) 1 NC_009566.1 COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases; coproporphyrinogen III oxidase 129099 5224726 CGSHiEE_00675 Haemophilus influenzae PittEE coproporphyrinogen III oxidase YP_001290010.1 128170 R 374930 CDS YP_001290011.1 148825258 5225262 complement(129440..131851) 1 NC_009566.1 COG0466 ATP-dependent Lon protease, bacterial type; ATP-dependent proteinase 131851 5225262 CGSHiEE_00680 Haemophilus influenzae PittEE ATP-dependent proteinase YP_001290011.1 129440 R 374930 CDS YP_001290012.1 148825259 5225263 132125..132919 1 NC_009566.1 COG2990 Uncharacterized protein conserved in bacteria; hypothetical protein 132919 5225263 CGSHiEE_00685 Haemophilus influenzae PittEE hypothetical protein YP_001290012.1 132125 D 374930 CDS YP_001290013.1 148825260 5225264 complement(132969..133760) 1 NC_009566.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase 133760 mazG 5225264 mazG Haemophilus influenzae PittEE nucleoside triphosphate pyrophosphohydrolase YP_001290013.1 132969 R 374930 CDS YP_001290014.1 148825261 5225265 133892..134431 1 NC_009566.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase 134431 5225265 CGSHiEE_00695 Haemophilus influenzae PittEE bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase YP_001290014.1 133892 D 374930 CDS YP_001290015.1 148825262 5225266 134507..135442 1 NC_009566.1 COG0760 Parvulin-like peptidyl-prolyl isomerase; stationary-phase survival protein SurA 135442 5225266 CGSHiEE_00700 Haemophilus influenzae PittEE stationary-phase survival protein SurA YP_001290015.1 134507 D 374930 CDS YP_001290016.1 148825263 5225267 135512..136555 1 NC_009566.1 COG1559 Predicted periplasmic solute-binding protein; pyrimidine regulatory protein PyrR 136555 5225267 CGSHiEE_00705 Haemophilus influenzae PittEE pyrimidine regulatory protein PyrR YP_001290016.1 135512 D 374930 CDS YP_001290017.1 148825264 5225277 136572..137204 1 NC_009566.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 137204 tmk 5225277 tmk Haemophilus influenzae PittEE thymidylate kinase YP_001290017.1 136572 D 374930 CDS YP_001290018.1 148825265 5225278 137201..138184 1 NC_009566.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 138184 5225278 CGSHiEE_00715 Haemophilus influenzae PittEE DNA polymerase III subunit delta' YP_001290018.1 137201 D 374930 CDS YP_001290019.1 148825266 5225279 138238..139020 1 NC_009566.1 putative deoxyribonuclease 139020 5225279 CGSHiEE_00720 Haemophilus influenzae PittEE putative deoxyribonuclease YP_001290019.1 138238 D 374930 CDS YP_001290020.1 148825267 5225280 139103..139570 1 NC_009566.1 COG0084 Mg-dependent DNase; hypothetical protein 139570 5225280 CGSHiEE_00725 Haemophilus influenzae PittEE hypothetical protein YP_001290020.1 139103 D 374930 CDS YP_001290021.1 148825268 5225281 139627..140919 1 NC_009566.1 COG1253 Hemolysins and related proteins containing CBS domains; hypothetical protein 140919 5225281 CGSHiEE_00730 Haemophilus influenzae PittEE hypothetical protein YP_001290021.1 139627 D 374930 CDS YP_001290022.1 148825269 5225331 140991..141182 1 NC_009566.1 hypothetical protein 141182 5225331 CGSHiEE_00735 Haemophilus influenzae PittEE hypothetical protein YP_001290022.1 140991 D 374930 CDS YP_001290023.1 148825270 5225332 141191..141328 1 NC_009566.1 virulence-associated protein D 141328 5225332 CGSHiEE_00740 Haemophilus influenzae PittEE virulence-associated protein D YP_001290023.1 141191 D 374930 CDS YP_001290024.1 148825271 5225333 141509..141952 1 NC_009566.1 COG1191 DNA-directed RNA polymerase specialized sigma subunit; hypothetical protein 141952 5225333 CGSHiEE_00745 Haemophilus influenzae PittEE hypothetical protein YP_001290024.1 141509 D 374930 CDS YP_001290025.1 148825272 5225334 142024..143523 1 NC_009566.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein 143523 5225334 CGSHiEE_00750 Haemophilus influenzae PittEE bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein YP_001290025.1 142024 D 374930 CDS YP_001290026.1 148825273 5225335 143525..144466 1 NC_009566.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase 144466 fruK 5225335 fruK Haemophilus influenzae PittEE 1-phosphofructokinase YP_001290026.1 143525 D 374930 CDS YP_001290027.1 148825274 5225336 144468..146138 1 NC_009566.1 COG3925 N-terminal domain of the phosphotransferase system fructose-specific component IIB; 1-phosphofructokinase 146138 fruK 5225336 fruK Haemophilus influenzae PittEE 1-phosphofructokinase YP_001290027.1 144468 D 374930 CDS YP_001290028.1 148825275 5225663 complement(146684..147022) 1 NC_009566.1 COG1314 Preprotein translocase subunit SecG; preprotein translocase subunit SecG 147022 secG 5225663 secG Haemophilus influenzae PittEE preprotein translocase subunit SecG YP_001290028.1 146684 R 374930 CDS YP_001290029.1 148825276 5225664 complement(147130..149085) 1 NC_009566.1 decatenates replicating daughter chromosomes; DNA topoisomerase III 149085 5225664 CGSHiEE_00770 Haemophilus influenzae PittEE DNA topoisomerase III YP_001290029.1 147130 R 374930 CDS YP_001290030.1 148825277 5225665 complement(149101..149703) 1 NC_009566.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 149703 recR 5225665 recR Haemophilus influenzae PittEE recombination protein RecR YP_001290030.1 149101 R 374930 CDS YP_001290031.1 148825278 5225666 complement(149761..150090) 1 NC_009566.1 COG0718 Uncharacterized protein conserved in bacteria; hypothetical protein 150090 5225666 CGSHiEE_00780 Haemophilus influenzae PittEE hypothetical protein YP_001290031.1 149761 R 374930 CDS YP_001290032.1 148825279 5225667 complement(150243..151088) 1 NC_009566.1 COG2961 Protein involved in catabolism of external DNA; hypothetical protein 151088 5225667 CGSHiEE_00785 Haemophilus influenzae PittEE hypothetical protein YP_001290032.1 150243 R 374930 CDS YP_001290033.1 148825280 5224867 complement(151161..153761) 1 NC_009566.1 COG5009 Membrane carboxypeptidase/penicillin-binding protein; penicillin-binding protein 1A 153761 5224867 CGSHiEE_00790 Haemophilus influenzae PittEE penicillin-binding protein 1A YP_001290033.1 151161 R 374930 CDS YP_001290034.1 148825281 5225652 153860..154657 1 NC_009566.1 COG0133 Tryptophan synthase beta chain; competence protein A 154657 5225652 CGSHiEE_00795 Haemophilus influenzae PittEE competence protein A YP_001290034.1 153860 D 374930 CDS YP_001290035.1 148825282 5225653 154658..155164 1 NC_009566.1 COG0419 ATPase involved in DNA repair; competence protein B 155164 5225653 CGSHiEE_00800 Haemophilus influenzae PittEE competence protein B YP_001290035.1 154658 D 374930 CDS YP_001290036.1 148825283 5225654 155161..155682 1 NC_009566.1 competence protein C 155682 5225654 CGSHiEE_00805 Haemophilus influenzae PittEE competence protein C YP_001290036.1 155161 D 374930 CDS YP_001290037.1 148825284 5225655 155679..156092 1 NC_009566.1 COG1196 Chromosome segregation ATPases; competence protein D 156092 5225655 CGSHiEE_00810 Haemophilus influenzae PittEE competence protein D YP_001290037.1 155679 D 374930 CDS YP_001290038.1 148825285 5225656 156102..157439 1 NC_009566.1 COG4796 Type II secretory pathway, component HofQ; competence protein E 157439 5225656 CGSHiEE_00815 Haemophilus influenzae PittEE competence protein E YP_001290038.1 156102 D 374930 CDS YP_001290039.1 148825286 5225422 157452..158138 1 NC_009566.1 COG1040 Predicted amidophosphoribosyltransferases; competence protein F 158138 recR 5225422 recR Haemophilus influenzae PittEE competence protein F YP_001290039.1 157452 D 374930 CDS YP_001290040.1 148825287 5225423 158214..158810 1 NC_009566.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; putative DNA uptake protein 158810 5225423 CGSHiEE_00825 Haemophilus influenzae PittEE putative DNA uptake protein YP_001290040.1 158214 D 374930 CDS YP_001290041.1 148825288 5225424 158877..159671 1 NC_009566.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 159671 nudC 5225424 nudC Haemophilus influenzae PittEE NADH pyrophosphatase YP_001290041.1 158877 D 374930 CDS YP_001290042.1 148825289 5225425 159707..160297 1 NC_009566.1 COG3068 Uncharacterized protein conserved in bacteria; hypothetical protein 160297 5225425 CGSHiEE_00835 Haemophilus influenzae PittEE hypothetical protein YP_001290042.1 159707 D 374930 CDS YP_001290043.1 148825290 5225426 160437..160709 1 NC_009566.1 COG0776 Bacterial nucleoid DNA-binding protein; NADH pyrophosphatase 160709 nudC 5225426 nudC Haemophilus influenzae PittEE NADH pyrophosphatase YP_001290043.1 160437 D 374930 CDS YP_001290044.1 148825291 5226253 160822..162654 1 NC_009566.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 162654 5226253 CGSHiEE_00845 Haemophilus influenzae PittEE glucosamine--fructose-6-phosphate aminotransferase YP_001290044.1 160822 D 374930 CDS YP_001290045.1 148825292 5226254 complement(162706..163239) 1 NC_009566.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 163239 5226254 CGSHiEE_00850 Haemophilus influenzae PittEE disulfide bond formation protein B YP_001290045.1 162706 R 374930 CDS YP_001290046.1 148825293 5226255 164921..165646 1 NC_009566.1 Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 165646 5226255 CGSHiEE_00865 Haemophilus influenzae PittEE fatty acid metabolism regulator YP_001290046.1 164921 D 374930 CDS YP_001290047.1 148825294 5226256 complement(165691..167058) 1 NC_009566.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 167058 pssA 5226256 pssA Haemophilus influenzae PittEE phosphatidylserine synthase YP_001290047.1 165691 R 374930 CDS YP_001290048.1 148825295 5226257 167204..167527 1 NC_009566.1 COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes; rRNA methylase 167527 5226257 CGSHiEE_00875 Haemophilus influenzae PittEE rRNA methylase YP_001290048.1 167204 D 374930 CDS YP_001290049.1 148825296 5225342 167556..168260 1 NC_009566.1 COG0566 rRNA methylases; rRNA methylase 168260 5225342 CGSHiEE_00880 Haemophilus influenzae PittEE rRNA methylase YP_001290049.1 167556 D 374930 CDS YP_001290050.1 148825297 5225343 complement(168292..168990) 1 NC_009566.1 COG4123 Predicted O-methyltransferase; phosphatidylserine synthase 168990 pssA 5225343 pssA Haemophilus influenzae PittEE phosphatidylserine synthase YP_001290050.1 168292 R 374930 CDS YP_001290051.1 148825298 5225344 169060..170379 1 NC_009566.1 facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 170379 5225344 CGSHiEE_00890 Haemophilus influenzae PittEE ATP-dependent RNA helicase SrmB YP_001290051.1 169060 D 374930 CDS YP_001290052.1 148825299 5225345 complement(170413..171792) 1 NC_009566.1 putative protease 171792 5225345 CGSHiEE_00895 Haemophilus influenzae PittEE putative protease YP_001290052.1 170413 R 374930 CDS YP_001290053.1 148825300 5225346 171848..171949 1 NC_009566.1 COG0826 Collagenase and related proteases; hypothetical protein 171949 5225346 CGSHiEE_00900 Haemophilus influenzae PittEE hypothetical protein YP_001290053.1 171848 D 374930 CDS YP_001290054.1 148825301 5225347 complement(171961..173268) 1 NC_009566.1 COG0477 Permeases of the major facilitator superfamily; ATP-dependent RNA helicase SrmB 173268 5225347 CGSHiEE_00905 Haemophilus influenzae PittEE ATP-dependent RNA helicase SrmB YP_001290054.1 171961 R 374930 CDS YP_001290055.1 148825302 5225337 complement(173252..173932) 1 NC_009566.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 173932 thiE 5225337 thiE Haemophilus influenzae PittEE thiamine-phosphate pyrophosphorylase YP_001290055.1 173252 R 374930 CDS YP_001290056.1 148825303 5225338 complement(173943..174752) 1 NC_009566.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 174752 5225338 CGSHiEE_00915 Haemophilus influenzae PittEE phosphomethylpyrimidine kinase YP_001290056.1 173943 R 374930 CDS YP_001290057.1 148825304 5225339 complement(174745..175536) 1 NC_009566.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 175536 5225339 CGSHiEE_00920 Haemophilus influenzae PittEE hydroxyethylthiazole kinase YP_001290057.1 174745 R 374930 CDS YP_001290058.1 148825305 5225340 complement(175866..176102) 1 NC_009566.1 COG2145 Hydroxyethylthiazole kinase, sugar kinase family; outer membrane opacity protein B 176102 5225340 CGSHiEE_00925 Haemophilus influenzae PittEE outer membrane opacity protein B YP_001290058.1 175866 R 374930 CDS YP_001290059.1 148825306 5225341 complement(176256..179063) 1 NC_009566.1 COG1530 Ribonucleases G and E; ribonuclease E 179063 5225341 CGSHiEE_00930 Haemophilus influenzae PittEE ribonuclease E YP_001290059.1 176256 R 374930 CDS YP_001290060.1 148825307 5225312 179485..180453 1 NC_009566.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 180453 5225312 CGSHiEE_00935 Haemophilus influenzae PittEE 23S rRNA pseudouridylate synthase C YP_001290060.1 179485 D 374930 CDS YP_001290061.1 148825308 5225313 180544..180819 1 NC_009566.1 Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 180819 hfq 5225313 hfq Haemophilus influenzae PittEE RNA-binding protein Hfq YP_001290061.1 180544 D 374930 CDS YP_001290062.1 148825309 5225314 complement(180915..181871) 1 NC_009566.1 COG3283 Transcriptional regulator of aromatic amino acids metabolism; transcriptional regulatory protein 181871 5225314 CGSHiEE_00945 Haemophilus influenzae PittEE transcriptional regulatory protein YP_001290062.1 180915 R 374930 CDS YP_001290063.1 148825310 5225315 complement(181986..183407) 1 NC_009566.1 COG0739 Membrane proteins related to metalloendopeptidases; hypothetical protein 183407 5225315 CGSHiEE_00950 Haemophilus influenzae PittEE hypothetical protein YP_001290063.1 181986 R 374930 CDS YP_001290064.1 148825311 5225316 183585..184391 1 NC_009566.1 COG1121 ABC-type Mn/Zn transport systems, ATPase component; ABC transporter ATP-binding protein 184391 5225316 CGSHiEE_00955 Haemophilus influenzae PittEE ABC transporter ATP-binding protein YP_001290064.1 183585 D 374930 CDS YP_001290065.1 148825312 5225317 184391..185176 1 NC_009566.1 COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; 23S rRNA pseudouridylate synthase C 185176 5225317 CGSHiEE_00960 Haemophilus influenzae PittEE 23S rRNA pseudouridylate synthase C YP_001290065.1 184391 D 374930 CDS YP_001290066.1 148825313 5225307 185265..186212 1 NC_009566.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 186212 5225307 CGSHiEE_00965 Haemophilus influenzae PittEE acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_001290066.1 185265 D 374930 CDS YP_001290067.1 148825314 5225308 186285..187151 1 NC_009566.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 187151 5225308 CGSHiEE_00970 Haemophilus influenzae PittEE pyridoxamine kinase YP_001290067.1 186285 D 374930 CDS YP_001290068.1 148825315 5225309 187151..188443 1 NC_009566.1 COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control; pyridoxine kinase 188443 5225309 CGSHiEE_00975 Haemophilus influenzae PittEE pyridoxine kinase YP_001290068.1 187151 D 374930 CDS YP_001290069.1 148825316 5225310 complement(188451..189122) 1 NC_009566.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 189122 5225310 CGSHiEE_00980 Haemophilus influenzae PittEE DNA mismatch repair protein YP_001290069.1 188451 R 374930 CDS YP_001290070.1 148825317 5225311 complement(189119..189658) 1 NC_009566.1 COG0350 Methylated DNA-protein cysteine methyltransferase; methylated-DNA-protein-cysteine methyltransferase 189658 5225311 CGSHiEE_00985 Haemophilus influenzae PittEE methylated-DNA-protein-cysteine methyltransferase YP_001290070.1 189119 R 374930 CDS YP_001290071.1 148825318 5225222 complement(189734..191104) 1 NC_009566.1 COG2067 Long-chain fatty acid transport protein; long-chain fatty acid transport protein 191104 5225222 CGSHiEE_00990 Haemophilus influenzae PittEE long-chain fatty acid transport protein YP_001290071.1 189734 R 374930 CDS YP_001290072.1 148825319 5225223 191310..191597 1 NC_009566.1 COG3691 Uncharacterized protein conserved in bacteria; hypothetical protein 191597 5225223 CGSHiEE_00995 Haemophilus influenzae PittEE hypothetical protein YP_001290072.1 191310 D 374930 CDS YP_001290073.1 148825320 5225224 complement(191695..192519) 1 NC_009566.1 COG1409 Predicted phosphohydrolases; cyclic 3',5'-adenosine monophosphate phosphodiesterase 192519 5225224 CGSHiEE_01000 Haemophilus influenzae PittEE cyclic 3',5'-adenosine monophosphate phosphodiesterase YP_001290073.1 191695 R 374930 CDS YP_001290074.1 148825321 5225225 complement(192529..193161) 1 NC_009566.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; cyclic 3',5'-adenosine monophosphate phosphodiesterase 193161 5225225 CGSHiEE_01005 Haemophilus influenzae PittEE cyclic 3',5'-adenosine monophosphate phosphodiesterase YP_001290074.1 192529 R 374930 CDS YP_001290075.1 148825322 5225226 complement(193360..194688) 1 NC_009566.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 194688 xseA 5225226 xseA Haemophilus influenzae PittEE exodeoxyribonuclease VII large subunit YP_001290075.1 193360 R 374930 CDS YP_001290076.1 148825323 5225227 complement(194681..195895) 1 NC_009566.1 COG2850 Uncharacterized conserved protein; exodeoxyribonuclease VII large subunit 195895 xseA 5225227 xseA Haemophilus influenzae PittEE exodeoxyribonuclease VII large subunit YP_001290076.1 194681 R 374930 CDS YP_001290077.1 148825324 5225214 complement(195898..196206) 1 NC_009566.1 COG2914 Uncharacterized protein conserved in bacteria; hypothetical protein 196206 5225214 CGSHiEE_01020 Haemophilus influenzae PittEE hypothetical protein YP_001290077.1 195898 R 374930 CDS YP_001290078.1 148825325 5225215 196483..196974 1 NC_009566.1 COG0193 Peptidyl-tRNA hydrolase; peptidyl-tRNA hydrolase 196974 5225215 CGSHiEE_01025 Haemophilus influenzae PittEE peptidyl-tRNA hydrolase YP_001290078.1 196483 D 374930 CDS YP_001290079.1 148825326 5225216 197022..198113 1 NC_009566.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 198113 5225216 CGSHiEE_01030 Haemophilus influenzae PittEE GTP-dependent nucleic acid-binding protein EngD YP_001290079.1 197022 D 374930 CDS YP_001290080.1 148825327 5225217 complement(200093..201235) 1 NC_009566.1 COG0349 Ribonuclease D; ribonuclease D 201235 5225217 CGSHiEE_01045 Haemophilus influenzae PittEE ribonuclease D YP_001290080.1 200093 R 374930 CDS YP_001290081.1 148825328 5225194 complement(201291..202979) 1 NC_009566.1 Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 202979 5225194 CGSHiEE_01050 Haemophilus influenzae PittEE long-chain-fatty-acid--CoA ligase YP_001290081.1 201291 R 374930 CDS YP_001290082.1 148825329 5225195 complement(203022..203573) 1 NC_009566.1 COG3065 Starvation-inducible outer membrane lipoprotein; outer membrane protein 203573 5225195 CGSHiEE_01055 Haemophilus influenzae PittEE outer membrane protein YP_001290082.1 203022 R 374930 CDS YP_001290083.1 148825330 5225196 complement(203598..204308) 1 NC_009566.1 COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone; hypothetical protein 204308 5225196 CGSHiEE_01060 Haemophilus influenzae PittEE hypothetical protein YP_001290083.1 203598 R 374930 CDS YP_001290084.1 148825331 5225197 complement(204321..206243) 1 NC_009566.1 COG1199 Rad3-related DNA helicases; ATP-dependent helicase 206243 5225197 CGSHiEE_01065 Haemophilus influenzae PittEE ATP-dependent helicase YP_001290084.1 204321 R 374930 CDS YP_001290085.1 148825332 5225198 206570..206980 1 NC_009566.1 COG0824 Predicted thioesterase; thioesterase 206980 5225198 CGSHiEE_01070 Haemophilus influenzae PittEE thioesterase YP_001290085.1 206570 D 374930 CDS YP_001290086.1 148825333 5225199 206997..207683 1 NC_009566.1 COG0811 Biopolymer transport proteins; long-chain-fatty-acid--CoA ligase 207683 5225199 CGSHiEE_01075 Haemophilus influenzae PittEE long-chain-fatty-acid--CoA ligase YP_001290086.1 206997 D 374930 CDS YP_001290087.1 148825334 5225109 207754..208173 1 NC_009566.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 208173 5225109 CGSHiEE_01080 Haemophilus influenzae PittEE colicin uptake protein TolR YP_001290087.1 207754 D 374930 CDS YP_001290088.1 148825335 5225110 208189..209367 1 NC_009566.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 209367 tolA 5225110 tolA Haemophilus influenzae PittEE cell envelope integrity inner membrane protein TolA YP_001290088.1 208189 D 374930 CDS YP_001290089.1 148825336 5225111 209409..210692 1 NC_009566.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 210692 tolB 5225111 tolB Haemophilus influenzae PittEE translocation protein TolB YP_001290089.1 209409 D 374930 CDS YP_001290090.1 148825337 5225112 210716..211177 1 NC_009566.1 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; outer membrane protein P6 211177 5225112 CGSHiEE_01095 Haemophilus influenzae PittEE outer membrane protein P6 YP_001290090.1 210716 D 374930 CDS YP_001290091.1 148825338 5225113 212396..212848 1 NC_009566.1 COG1959 Predicted transcriptional regulator; hypothetical protein 212848 5225113 CGSHiEE_01110 Haemophilus influenzae PittEE hypothetical protein YP_001290091.1 212396 D 374930 CDS YP_001290092.1 148825339 5225031 212916..214130 1 NC_009566.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 214130 tolB 5225031 tolB Haemophilus influenzae PittEE cysteine desulfurase YP_001290092.1 212916 D 374930 CDS YP_001290093.1 148825340 5225032 214189..214569 1 NC_009566.1 COG0822 NifU homolog involved in Fe-S cluster formation; scaffold protein 214569 5225032 CGSHiEE_01120 Haemophilus influenzae PittEE scaffold protein YP_001290093.1 214189 D 374930 CDS YP_001290094.1 148825341 5224949 214627..214950 1 NC_009566.1 COG0316 Uncharacterized conserved protein; hypothetical protein 214950 5224949 CGSHiEE_01125 Haemophilus influenzae PittEE hypothetical protein YP_001290094.1 214627 D 374930 CDS YP_001290095.1 148825342 5224950 214991..215488 1 NC_009566.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB 215488 hscB 5224950 hscB Haemophilus influenzae PittEE co-chaperone HscB YP_001290095.1 214991 D 374930 CDS YP_001290096.1 148825343 5224951 215539..216225 1 NC_009566.1 COG1076 DnaJ-domain-containing proteins 1; hypothetical protein 216225 5224951 CGSHiEE_01135 Haemophilus influenzae PittEE hypothetical protein YP_001290096.1 215539 D 374930 CDS YP_001290097.1 148825344 5224952 216244..218103 1 NC_009566.1 involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 218103 hscA 5224952 hscA Haemophilus influenzae PittEE chaperone protein HscA YP_001290097.1 216244 D 374930 CDS YP_001290098.1 148825345 5224953 218143..218484 1 NC_009566.1 COG0633 Ferredoxin; ferredoxin, 2Fe-2S 218484 5224953 CGSHiEE_01145 Haemophilus influenzae PittEE ferredoxin, 2Fe-2S YP_001290098.1 218143 D 374930 CDS YP_001290099.1 148825346 5224895 218484..218678 1 NC_009566.1 COG2975 Uncharacterized protein conserved in bacteria; hypothetical protein 218678 5224895 CGSHiEE_01150 Haemophilus influenzae PittEE hypothetical protein YP_001290099.1 218484 D 374930 CDS YP_001290100.1 148825347 5224896 complement(218729..219343) 1 NC_009566.1 COG2976 Uncharacterized protein conserved in bacteria; hypothetical protein 219343 hscA 5224896 hscA Haemophilus influenzae PittEE hypothetical protein YP_001290100.1 218729 R 374930 CDS YP_001290101.1 148825348 5224897 complement(219361..220632) 1 NC_009566.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 220632 hisS 5224897 hisS Haemophilus influenzae PittEE histidyl-tRNA synthetase YP_001290101.1 219361 R 374930 CDS YP_001290102.1 148825349 5224898 complement(220642..220710) 1 NC_009566.1 COG0124 Histidyl-tRNA synthetase; hypothetical protein 220710 5224898 CGSHiEE_01165 Haemophilus influenzae PittEE hypothetical protein YP_001290102.1 220642 R 374930 CDS YP_001290103.1 148825350 5224899 complement(220710..221747) 1 NC_009566.1 COG0821 Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 221747 5224899 CGSHiEE_01170 Haemophilus influenzae PittEE 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_001290103.1 220710 R 374930 CDS YP_001290104.1 148825351 5224752 complement(221756..222667) 1 NC_009566.1 COG1426 Uncharacterized protein conserved in bacteria; hypothetical protein 222667 5224752 CGSHiEE_01175 Haemophilus influenzae PittEE hypothetical protein YP_001290104.1 221756 R 374930 CDS YP_001290105.1 148825352 5224753 complement(222739..223278) 1 NC_009566.1 COG3063 Tfp pilus assembly protein PilF; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 223278 ispG 5224753 ispG Haemophilus influenzae PittEE 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_001290105.1 222739 R 374930 CDS YP_001290106.1 148825353 5224754 complement(223379..224530) 1 NC_009566.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 224530 5224754 CGSHiEE_01185 Haemophilus influenzae PittEE ribosomal RNA large subunit methyltransferase N YP_001290106.1 223379 R 374930 CDS YP_001290107.1 148825354 5224755 224777..225655 1 NC_009566.1 COG1686 D-alanyl-D-alanine carboxypeptidase; hypothetical protein 225655 5224755 CGSHiEE_01190 Haemophilus influenzae PittEE hypothetical protein YP_001290107.1 224777 D 374930 CDS YP_001290108.1 148825355 5224756 complement(225749..226213) 1 NC_009566.1 COG3064 Membrane protein involved in colicin uptake; hypothetical protein 226213 5224756 CGSHiEE_01195 Haemophilus influenzae PittEE hypothetical protein YP_001290108.1 225749 R 374930 CDS YP_001290109.1 148825356 5224757 226520..227401 1 NC_009566.1 COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin; putative periplasmic chelated iron binding protein 227401 5224757 CGSHiEE_01200 Haemophilus influenzae PittEE putative periplasmic chelated iron binding protein YP_001290109.1 226520 D 374930 CDS YP_001290110.1 148825357 5224717 227401..228321 1 NC_009566.1 COG1121 ABC-type Mn/Zn transport systems, ATPase component; iron (chelated) transporter ATP-binding protein 228321 5224717 CGSHiEE_01205 Haemophilus influenzae PittEE iron (chelated) transporter ATP-binding protein YP_001290110.1 227401 D 374930 CDS YP_001290111.1 148825358 5224718 228325..229173 1 NC_009566.1 COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; iron (chelated) ABC transporter permease protein 229173 5224718 CGSHiEE_01210 Haemophilus influenzae PittEE iron (chelated) ABC transporter permease protein YP_001290111.1 228325 D 374930 CDS YP_001290112.1 148825359 5224719 229166..229981 1 NC_009566.1 COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; iron (chelated) ABC transporter permease protein 229981 5224719 CGSHiEE_01215 Haemophilus influenzae PittEE iron (chelated) ABC transporter permease protein YP_001290112.1 229166 D 374930 CDS YP_001290113.1 148825360 5224720 complement(230081..230728) 1 NC_009566.1 COG0819 Putative transcription activator; transcriptional activator 230728 5224720 CGSHiEE_01220 Haemophilus influenzae PittEE transcriptional activator YP_001290113.1 230081 R 374930 CDS YP_001290114.1 148825361 5224721 complement(230738..231682) 1 NC_009566.1 COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components; thiamine biosynthesis protein 231682 5224721 CGSHiEE_01225 Haemophilus influenzae PittEE thiamine biosynthesis protein YP_001290114.1 230738 R 374930 CDS YP_001290115.1 148825362 5225527 complement(231704..232441) 1 NC_009566.1 COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component; putative ABC-type nitrate/sulfonate/bicarbonate transport system, permease 232441 5225527 CGSHiEE_01230 Haemophilus influenzae PittEE putative ABC-type nitrate/sulfonate/bicarbonate transport system, permease YP_001290115.1 231704 R 374930 CDS YP_001290116.1 148825363 5225528 complement(232438..233160) 1 NC_009566.1 putative ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase 233160 5225528 CGSHiEE_01235 Haemophilus influenzae PittEE putative ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase YP_001290116.1 232438 R 374930 CDS YP_001290117.1 148825364 5225529 233559..234443 1 NC_009566.1 COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component; CMP-neu5Ac--lipooligosaccharide alpha 2-3 sialyltransferase 234443 5225529 CGSHiEE_01240 Haemophilus influenzae PittEE CMP-neu5Ac--lipooligosaccharide alpha 2-3 sialyltransferase YP_001290117.1 233559 D 374930 CDS YP_001290118.1 148825365 5225530 234693..235709 1 NC_009566.1 COG1087 UDP-glucose 4-epimerase; UDP-glucose 4-epimerase 235709 5225530 CGSHiEE_01245 Haemophilus influenzae PittEE UDP-glucose 4-epimerase YP_001290118.1 234693 D 374930 CDS YP_001290119.1 148825366 5225531 235890..237128 1 NC_009566.1 COG0477 Permeases of the major facilitator superfamily; hypothetical protein 237128 5225531 CGSHiEE_01250 Haemophilus influenzae PittEE hypothetical protein YP_001290119.1 235890 D 374930 CDS YP_001290120.1 148825367 5225532 237211..237855 1 NC_009566.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 237855 adk 5225532 adk Haemophilus influenzae PittEE adenylate kinase YP_001290120.1 237211 D 374930 CDS YP_001290121.1 148825368 5225784 complement(238015..238617) 1 NC_009566.1 COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit; cytochrome C-type protein NapC 238617 5225784 CGSHiEE_01260 Haemophilus influenzae PittEE cytochrome C-type protein NapC YP_001290121.1 238015 R 374930 CDS YP_001290122.1 148825369 5225785 complement(238632..239075) 1 NC_009566.1 COG3043 Nitrate reductase cytochrome c-type subunit; adenylate kinase 239075 adk 5225785 adk Haemophilus influenzae PittEE adenylate kinase YP_001290122.1 238632 R 374930 CDS YP_001290123.1 148825370 5225786 complement(239081..239944) 1 NC_009566.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component 239944 napH 5225786 napH Haemophilus influenzae PittEE quinol dehydrogenase membrane component YP_001290123.1 239081 R 374930 CDS YP_001290124.1 148825371 5225787 complement(239944..240777) 1 NC_009566.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component 240777 napG 5225787 napG Haemophilus influenzae PittEE quinol dehydrogenase periplasmic component YP_001290124.1 239944 R 374930 CDS YP_001290125.1 148825372 5225788 complement(240838..243321) 1 NC_009566.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit 243321 5225788 CGSHiEE_01280 Haemophilus influenzae PittEE nitrate reductase catalytic subunit YP_001290125.1 240838 R 374930 CDS YP_001290126.1 148825373 5226114 complement(243358..243639) 1 NC_009566.1 hypothetical protein 243639 5226114 CGSHiEE_01285 Haemophilus influenzae PittEE hypothetical protein YP_001290126.1 243358 R 374930 CDS YP_001290127.1 148825374 5226115 complement(243632..244162) 1 NC_009566.1 COG1145 Ferredoxin; quinol dehydrogenase periplasmic component 244162 napG 5226115 napG Haemophilus influenzae PittEE quinol dehydrogenase periplasmic component YP_001290127.1 243632 R 374930 CDS YP_001290128.1 148825375 5226116 complement(244368..244712) 1 NC_009566.1 COG3171 Uncharacterized protein conserved in bacteria; hypothetical protein 244712 5226116 CGSHiEE_01295 Haemophilus influenzae PittEE hypothetical protein YP_001290128.1 244368 R 374930 CDS YP_001290129.1 148825376 5226117 complement(244797..245537) 1 NC_009566.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 245537 trmB 5226117 trmB Haemophilus influenzae PittEE tRNA (guanine-N(7)-)-methyltransferase YP_001290129.1 244797 R 374930 CDS YP_001290130.1 148825377 5226118 245622..247814 1 NC_009566.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 247814 5226118 CGSHiEE_01305 Haemophilus influenzae PittEE primosome assembly protein PriA YP_001290130.1 245622 D 374930 CDS YP_001290131.1 148825378 5226119 complement(247856..248902) 1 NC_009566.1 COG0628 Predicted permease; hypothetical protein 248902 5226119 CGSHiEE_01310 Haemophilus influenzae PittEE hypothetical protein YP_001290131.1 247856 R 374930 CDS YP_001290132.1 148825379 5225402 complement(248902..249240) 1 NC_009566.1 COG0347 Nitrogen regulatory protein PII; nitrogen regulatory protein P-II 249240 5225402 CGSHiEE_01315 Haemophilus influenzae PittEE nitrogen regulatory protein P-II YP_001290132.1 248902 R 374930 CDS YP_001290133.1 148825380 5225403 complement(249242..249835) 1 NC_009566.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 249835 mogA 5225403 mogA Haemophilus influenzae PittEE molybdenum cofactor biosynthesis protein MogA YP_001290133.1 249242 R 374930 CDS YP_001290134.1 148825381 5225404 complement(249918..250274) 1 NC_009566.1 COG0818 Diacylglycerol kinase; diacylglycerol kinase 250274 5225404 CGSHiEE_01325 Haemophilus influenzae PittEE diacylglycerol kinase YP_001290134.1 249918 R 374930 CDS YP_001290135.1 148825382 5225405 complement(250289..252520) 1 NC_009566.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; GTP pyrophosphokinase 252520 5225405 CGSHiEE_01330 Haemophilus influenzae PittEE GTP pyrophosphokinase YP_001290135.1 250289 R 374930 CDS YP_001290136.1 148825383 5225406 complement(252740..253321) 1 NC_009566.1 COG1403 Restriction endonuclease; HNH endonuclease 253321 5225406 CGSHiEE_01335 Haemophilus influenzae PittEE HNH endonuclease YP_001290136.1 252740 R 374930 CDS YP_001290137.1 148825384 5225407 complement(253327..253944) 1 NC_009566.1 COG0784 FOG: CheY-like receiver; hypothetical protein 253944 5225407 CGSHiEE_01340 Haemophilus influenzae PittEE hypothetical protein YP_001290137.1 253327 R 374930 CDS YP_001290138.1 148825385 5225161 complement(253960..256245) 1 NC_009566.1 COG0326 Molecular chaperone, HSP90 family; histidine kinase 256245 5225161 CGSHiEE_01345 Haemophilus influenzae PittEE histidine kinase YP_001290138.1 253960 R 374930 CDS YP_001290139.1 148825386 5225162 complement(259333..260043) 1 NC_009566.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 260043 recO 5225162 recO Haemophilus influenzae PittEE DNA repair protein RecO YP_001290139.1 259333 R 374930 CDS YP_001290140.1 148825387 5225163 complement(260046..260450) 1 NC_009566.1 COG1381 Recombinational DNA repair protein (RecF pathway); opacity associated protein OapB 260450 5225163 CGSHiEE_01375 Haemophilus influenzae PittEE opacity associated protein OapB YP_001290140.1 260046 R 374930 CDS YP_001290141.1 148825388 5225072 complement(260510..261796) 1 NC_009566.1 COG0532 Translation initiation factor 2 (IF-2; GTPase); opacity associated protein 261796 5225072 CGSHiEE_01380 Haemophilus influenzae PittEE opacity associated protein YP_001290141.1 260510 R 374930 CDS YP_001290142.1 148825389 5225073 complement(261904..262920) 1 NC_009566.1 COG1509 Lysine 2,3-aminomutase; DNA repair protein RecO 262920 recO 5225073 recO Haemophilus influenzae PittEE DNA repair protein RecO YP_001290142.1 261904 R 374930 CDS YP_001290143.1 148825390 5225074 262958..263524 1 NC_009566.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 263524 5225074 CGSHiEE_01390 Haemophilus influenzae PittEE elongation factor P YP_001290143.1 262958 D 374930 CDS YP_001290144.1 148825391 5225075 complement(263876..264460) 1 NC_009566.1 COG3923 Primosomal replication protein N''; primosomal replication protein N 264460 5225075 CGSHiEE_01395 Haemophilus influenzae PittEE primosomal replication protein N YP_001290144.1 263876 R 374930 CDS YP_001290145.1 148825392 5225076 complement(266162..266851) 1 NC_009566.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 266851 5225076 CGSHiEE_01410 Haemophilus influenzae PittEE ribonuclease T YP_001290145.1 266162 R 374930 CDS YP_001290146.1 148825393 5225067 complement(266926..267333) 1 NC_009566.1 COG0346 Lactoylglutathione lyase and related lyases; lactoylglutathione lyase 267333 5225067 CGSHiEE_01415 Haemophilus influenzae PittEE lactoylglutathione lyase YP_001290146.1 266926 R 374930 CDS YP_001290147.1 148825394 5225069 complement(267400..267804) 1 NC_009566.1 COG1487 Predicted nucleic acid-binding protein, contains PIN domain; nucleic acid-binding protein 267804 5225069 CGSHiEE_01420 Haemophilus influenzae PittEE nucleic acid-binding protein YP_001290147.1 267400 R 374930 CDS YP_001290148.1 148825395 5225070 complement(267801..268037) 1 NC_009566.1 COG4456 Virulence-associated protein and related proteins; hypothetical protein 268037 5225070 CGSHiEE_01425 Haemophilus influenzae PittEE hypothetical protein YP_001290148.1 267801 R 374930 CDS YP_001290149.1 148825396 5225071 complement(268130..268855) 1 NC_009566.1 COG0500 SAM-dependent methyltransferases; S-adenosyl-L-methionine-dependent methyltransferase 268855 5225071 CGSHiEE_01430 Haemophilus influenzae PittEE S-adenosyl-L-methionine-dependent methyltransferase YP_001290149.1 268130 R 374930 CDS YP_001290150.1 148825397 5225008 complement(268908..269426) 1 NC_009566.1 COG1755 Uncharacterized protein conserved in bacteria; hypothetical protein 269426 5225008 CGSHiEE_01435 Haemophilus influenzae PittEE hypothetical protein YP_001290150.1 268908 R 374930 CDS YP_001290151.1 148825398 5225009 269647..271413 1 NC_009566.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 271413 aspS 5225009 aspS Haemophilus influenzae PittEE aspartyl-tRNA synthetase YP_001290151.1 269647 D 374930 CDS YP_001290152.1 148825399 5225010 271475..272323 1 NC_009566.1 hypothetical protein 272323 5225010 CGSHiEE_01445 Haemophilus influenzae PittEE hypothetical protein YP_001290152.1 271475 D 374930 CDS YP_001290154.1 148825401 5225012 272906..273289 1 NC_009566.1 COG2932 Predicted transcriptional regulator; transcriptional regulatory protein 273289 5225012 CGSHiEE_01455 Haemophilus influenzae PittEE transcriptional regulatory protein YP_001290154.1 272906 D 374930 CDS YP_001290155.1 148825402 5224856 complement(273414..274121) 1 NC_009566.1 COG2801 Transposase and inactivated derivatives; transposase 274121 5224856 CGSHiEE_01460 Haemophilus influenzae PittEE transposase YP_001290155.1 273414 R 374930 CDS YP_001290156.1 148825403 5224857 complement(274220..274573) 1 NC_009566.1 transposase 274573 5224857 CGSHiEE_01465 Haemophilus influenzae PittEE transposase YP_001290156.1 274220 R 374930 CDS YP_001290157.1 148825404 5224858 274871..276139 1 NC_009566.1 COG1914 Mn2+ and Fe2+ transporters of the NRAMP family; aspartyl-tRNA synthetase 276139 aspS 5224858 aspS Haemophilus influenzae PittEE aspartyl-tRNA synthetase YP_001290157.1 274871 D 374930 CDS YP_001290158.1 148825405 5224859 276332..276697 1 NC_009566.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; dATP pyrophosphohydrolase 276697 ntpA 5224859 ntpA Haemophilus influenzae PittEE dATP pyrophosphohydrolase YP_001290158.1 276332 D 374930 CDS YP_001290159.1 148825406 5224860 276857..277597 1 NC_009566.1 COG0217 Uncharacterized conserved protein; hypothetical protein 277597 5224860 CGSHiEE_01480 Haemophilus influenzae PittEE hypothetical protein YP_001290159.1 276857 D 374930 CDS YP_001290160.1 148825407 5224861 277644..278216 1 NC_009566.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 278216 ruvC 5224861 ruvC Haemophilus influenzae PittEE Holliday junction resolvase YP_001290160.1 277644 D 374930 CDS YP_001290161.1 148825408 5225282 278279..278893 1 NC_009566.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 278893 ruvA 5225282 ruvA Haemophilus influenzae PittEE Holliday junction DNA helicase RuvA YP_001290161.1 278279 D 374930 CDS YP_001290162.1 148825409 5225283 278901..279908 1 NC_009566.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 279908 ruvB 5225283 ruvB Haemophilus influenzae PittEE Holliday junction DNA helicase RuvB YP_001290162.1 278901 D 374930 CDS YP_001290163.1 148825410 5225284 complement(279960..280247) 1 NC_009566.1 COG1196 Chromosome segregation ATPases; hypothetical protein 280247 ruvB 5225284 ruvB Haemophilus influenzae PittEE hypothetical protein YP_001290163.1 279960 R 374930 CDS YP_001290164.1 148825411 5225285 complement(280420..281313) 1 NC_009566.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 281313 xerD 5225285 xerD Haemophilus influenzae PittEE site-specific tyrosine recombinase XerD YP_001290164.1 280420 R 374930 CDS YP_001290165.1 148825412 5225286 complement(281344..282510) 1 NC_009566.1 putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; putative 3-phenylpropionic acid transporter 282510 5225286 CGSHiEE_01510 Haemophilus influenzae PittEE putative 3-phenylpropionic acid transporter YP_001290165.1 281344 R 374930 CDS YP_001290166.1 148825413 5225250 complement(282510..283325) 1 NC_009566.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 283325 5225250 CGSHiEE_01515 Haemophilus influenzae PittEE pyrroline-5-carboxylate reductase YP_001290166.1 282510 R 374930 CDS YP_001290167.1 148825414 5225251 283391..284299 1 NC_009566.1 Required for efficient pilin antigenic variation; recombination associated protein 284299 rdgC 5225251 rdgC Haemophilus influenzae PittEE recombination associated protein YP_001290167.1 283391 D 374930 CDS YP_001290168.1 148825415 5225252 complement(284349..284768) 1 NC_009566.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 284768 5225252 CGSHiEE_01525 Haemophilus influenzae PittEE Holliday junction resolvase-like protein YP_001290168.1 284349 R 374930 CDS YP_001290169.1 148825416 5225253 complement(284768..285328) 1 NC_009566.1 COG1678 Putative transcriptional regulator; hypothetical protein 285328 5225253 CGSHiEE_01530 Haemophilus influenzae PittEE hypothetical protein YP_001290169.1 284768 R 374930 CDS YP_001290170.1 148825417 5225254 complement(285325..286062) 1 NC_009566.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 286062 5225254 CGSHiEE_01535 Haemophilus influenzae PittEE 16S ribosomal RNA methyltransferase RsmE YP_001290170.1 285325 R 374930 CDS YP_001290171.1 148825418 5225255 complement(286112..287680) 1 NC_009566.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 287680 lnt 5225255 lnt Haemophilus influenzae PittEE apolipoprotein N-acyltransferase YP_001290171.1 286112 R 374930 CDS YP_001290172.1 148825419 5225137 complement(287664..288563) 1 NC_009566.1 COG4535 Putative Mg2+ and Co2+ transporter CorC; apolipoprotein N-acyltransferase 288563 lnt 5225137 lnt Haemophilus influenzae PittEE apolipoprotein N-acyltransferase YP_001290172.1 287664 R 374930 CDS YP_001290173.1 148825420 5225138 complement(289186..289746) 1 NC_009566.1 N-acetyl-anhydromuranmyl-L-alanine amidase 289746 5225138 CGSHiEE_01550 Haemophilus influenzae PittEE N-acetyl-anhydromuranmyl-L-alanine amidase YP_001290173.1 289186 R 374930 CDS YP_001290174.1 148825421 5225139 289860..290000 1 NC_009566.1 COG3023 Negative regulator of beta-lactamase expression; hypothetical protein 290000 5225139 CGSHiEE_01555 Haemophilus influenzae PittEE hypothetical protein YP_001290174.1 289860 D 374930 CDS YP_001290175.1 148825422 5225140 290035..290310 1 NC_009566.1 COG4969 Tfp pilus assembly protein, major pilin PilA; type IV pilin subunit protein 290310 5225140 CGSHiEE_01560 Haemophilus influenzae PittEE type IV pilin subunit protein YP_001290175.1 290035 D 374930 CDS YP_001290176.1 148825423 5225141 290307..291704 1 NC_009566.1 COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB; putative type IV pilin secretion protein 291704 5225141 CGSHiEE_01565 Haemophilus influenzae PittEE putative type IV pilin secretion protein YP_001290176.1 290307 D 374930 CDS YP_001290177.1 148825424 5225142 291701..292918 1 NC_009566.1 COG1459 Type II secretory pathway, component PulF; putative type IV pilin secretion protein 292918 5225142 CGSHiEE_01570 Haemophilus influenzae PittEE putative type IV pilin secretion protein YP_001290177.1 291701 D 374930 CDS YP_001290178.1 148825425 5225094 292915..293523 1 NC_009566.1 COG1835 Predicted acyltransferases; N-acetyl-anhydromuranmyl-L-alanine amidase 293523 5225094 CGSHiEE_01575 Haemophilus influenzae PittEE N-acetyl-anhydromuranmyl-L-alanine amidase YP_001290178.1 292915 D 374930 CDS YP_001290179.1 148825426 5225095 complement(293662..294924) 1 NC_009566.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 294924 rho 5225095 rho Haemophilus influenzae PittEE transcription termination factor Rho YP_001290179.1 293662 R 374930 CDS YP_001290180.1 148825427 5225096 295174..295491 1 NC_009566.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ 295491 5225096 CGSHiEE_01585 Haemophilus influenzae PittEE transcriptional repressor protein MetJ YP_001290180.1 295174 D 374930 CDS YP_001290181.1 148825428 5225097 complement(295505..295891) 1 NC_009566.1 COG0789 Predicted transcriptional regulators; transcriptional regulator MerR family protein 295891 5225097 CGSHiEE_01590 Haemophilus influenzae PittEE transcriptional regulator MerR family protein YP_001290181.1 295505 R 374930 CDS YP_001290182.1 148825429 5225098 295968..296174 1 NC_009566.1 COG2608 Copper chaperone; mercuric ion scavenger protein 296174 5225098 CGSHiEE_01595 Haemophilus influenzae PittEE mercuric ion scavenger protein YP_001290182.1 295968 D 374930 CDS YP_001290183.1 148825430 5225077 296260..296466 1 NC_009566.1 COG2608 Copper chaperone; mercuric ion scavenger protein 296466 5225077 CGSHiEE_01600 Haemophilus influenzae PittEE mercuric ion scavenger protein YP_001290183.1 296260 D 374930 CDS YP_001290184.1 148825431 5225078 296552..296758 1 NC_009566.1 COG2608 Copper chaperone; mercuric ion scavenger protein 296758 5225078 CGSHiEE_01605 Haemophilus influenzae PittEE mercuric ion scavenger protein YP_001290184.1 296552 D 374930 CDS YP_001290185.1 148825432 5225079 296733..298901 1 NC_009566.1 COG2217 Cation transport ATPase; putative cation-transporting ATPase 298901 5225079 CGSHiEE_01610 Haemophilus influenzae PittEE putative cation-transporting ATPase YP_001290185.1 296733 D 374930 CDS YP_001290186.1 148825433 5225080 299124..300362 1 NC_009566.1 COG0814 Amino acid permeases; serine transporter 300362 5225080 CGSHiEE_01615 Haemophilus influenzae PittEE serine transporter YP_001290186.1 299124 D 374930 CDS YP_001290187.1 148825434 5225081 300396..301763 1 NC_009566.1 COG1760 L-serine deaminase; L-serine deaminase 301763 5225081 CGSHiEE_01620 Haemophilus influenzae PittEE L-serine deaminase YP_001290187.1 300396 D 374930 CDS YP_001290188.1 148825435 5225082 complement(301889..303145) 1 NC_009566.1 COG0814 Amino acid permeases; tryptophan-specific transport protein 303145 5225082 CGSHiEE_01625 Haemophilus influenzae PittEE tryptophan-specific transport protein YP_001290188.1 301889 R 374930 CDS YP_001290189.1 148825436 5224986 complement(303263..304477) 1 NC_009566.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 304477 5224986 CGSHiEE_01630 Haemophilus influenzae PittEE aminotransferase AlaT YP_001290189.1 303263 R 374930 CDS YP_001290190.1 148825437 5224987 304612..305904 1 NC_009566.1 COG1169 Isochorismate synthase; menaquinone-specific isochorismate synthase 305904 5224987 CGSHiEE_01635 Haemophilus influenzae PittEE menaquinone-specific isochorismate synthase YP_001290190.1 304612 D 374930 CDS YP_001290191.1 148825438 5224988 305919..307625 1 NC_009566.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 307625 5224988 CGSHiEE_01640 Haemophilus influenzae PittEE 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase YP_001290191.1 305919 D 374930 CDS YP_001290192.1 148825439 5224989 307686..308429 1 NC_009566.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase YfbB 308429 5224989 CGSHiEE_01645 Haemophilus influenzae PittEE acyl-CoA thioester hydrolase YfbB YP_001290192.1 307686 D 374930 CDS YP_001290193.1 148825440 5224990 308485..309801 1 NC_009566.1 COG0477 Permeases of the major facilitator superfamily; acyl-CoA thioester hydrolase YfbB 309801 5224990 CGSHiEE_01650 Haemophilus influenzae PittEE acyl-CoA thioester hydrolase YfbB YP_001290193.1 308485 D 374930 CDS YP_001290194.1 148825441 5224970 complement(310030..310788) 1 NC_009566.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 310788 5224970 CGSHiEE_01655 Haemophilus influenzae PittEE uridine phosphorylase YP_001290194.1 310030 R 374930 CDS YP_001290195.1 148825442 5224971 311021..311587 1 NC_009566.1 COG2258 Uncharacterized protein conserved in bacteria; uridine phosphorylase 311587 5224971 CGSHiEE_01660 Haemophilus influenzae PittEE uridine phosphorylase YP_001290195.1 311021 D 374930 CDS YP_001290196.1 148825443 5224972 311687..312169 1 NC_009566.1 COG3012 Uncharacterized protein conserved in bacteria; hypothetical protein 312169 5224972 CGSHiEE_01665 Haemophilus influenzae PittEE hypothetical protein YP_001290196.1 311687 D 374930 CDS YP_001290197.1 148825444 5224973 312166..312975 1 NC_009566.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 312975 rbn 5224973 rbn Haemophilus influenzae PittEE ribonuclease BN YP_001290197.1 312166 D 374930 CDS YP_001290198.1 148825445 5224974 complement(312995..314650) 1 NC_009566.1 COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily; ribonuclease BN 314650 rbn 5224974 rbn Haemophilus influenzae PittEE ribonuclease BN YP_001290198.1 312995 R 374930 CDS YP_001290199.1 148825446 5224975 315400..316842 1 NC_009566.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 316842 gltX 5224975 gltX Haemophilus influenzae PittEE glutamyl-tRNA synthetase YP_001290199.1 315400 D 374930 CDS YP_001290200.1 148825447 5224960 317143..317859 1 NC_009566.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 317859 rph 5224960 rph Haemophilus influenzae PittEE ribonuclease PH YP_001290200.1 317143 D 374930 CDS YP_001290201.1 148825448 5224961 317883..318524 1 NC_009566.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 318524 pyrE 5224961 pyrE Haemophilus influenzae PittEE orotate phosphoribosyltransferase YP_001290201.1 317883 D 374930 CDS YP_001290202.1 148825449 5224962 318603..319469 1 NC_009566.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 319469 djlA 5224962 djlA Haemophilus influenzae PittEE Dna-J like membrane chaperone protein YP_001290202.1 318603 D 374930 CDS YP_001290203.1 148825450 5224963 319469..320401 1 NC_009566.1 COG0042 tRNA-dihydrouridine synthase; DnaJ-like membrane chaperone protein 320401 djlA 5224963 djlA Haemophilus influenzae PittEE DnaJ-like membrane chaperone protein YP_001290203.1 319469 D 374930 CDS YP_001290204.1 148825451 5224964 complement(320441..321286) 1 NC_009566.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 321286 5224964 CGSHiEE_01705 Haemophilus influenzae PittEE RNA polymerase factor sigma-32 YP_001290204.1 320441 R 374930 CDS YP_001290205.1 148825452 5224807 complement(321424..321735) 1 NC_009566.1 COG4390 Uncharacterized protein conserved in bacteria; RNA polymerase factor sigma-32 321735 5224807 CGSHiEE_01710 Haemophilus influenzae PittEE RNA polymerase factor sigma-32 YP_001290205.1 321424 R 374930 CDS YP_001290206.1 148825453 5224808 complement(321759..322784) 1 NC_009566.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 322784 murB 5224808 murB Haemophilus influenzae PittEE UDP-N-acetylenolpyruvoylglucosamine reductase YP_001290206.1 321759 R 374930 CDS YP_001290207.1 148825454 5224795 complement(322794..324497) 1 NC_009566.1 COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific; nitrate/nitrite sensor protein NarQ 324497 5224795 CGSHiEE_01720 Haemophilus influenzae PittEE nitrate/nitrite sensor protein NarQ YP_001290207.1 322794 R 374930 CDS YP_001290208.1 148825455 5224796 complement(324539..325138) 1 NC_009566.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY 325138 5224796 CGSHiEE_01725 Haemophilus influenzae PittEE putative glycerol-3-phosphate acyltransferase PlsY YP_001290208.1 324539 R 374930 CDS YP_001290209.1 148825456 5224797 325221..325577 1 NC_009566.1 COG1539 Dihydroneopterin aldolase; dihydroneopterin aldolase 325577 5224797 CGSHiEE_01730 Haemophilus influenzae PittEE dihydroneopterin aldolase YP_001290209.1 325221 D 374930 CDS YP_001290210.1 148825457 5224798 complement(325673..328411) 1 NC_009566.1 COG3210 Large exoproteins involved in heme utilization or adhesion; heme/hemopexin-binding protein A 328411 5224798 CGSHiEE_01735 Haemophilus influenzae PittEE heme/hemopexin-binding protein A YP_001290210.1 325673 R 374930 CDS YP_001290211.1 148825458 5224799 complement(328423..330111) 1 NC_009566.1 COG2831 Hemolysin activation/secretion protein; heme/hemopexin-binding protein B 330111 5224799 CGSHiEE_01740 Haemophilus influenzae PittEE heme/hemopexin-binding protein B YP_001290211.1 328423 R 374930 CDS YP_001290212.1 148825459 5224779 complement(330193..332355) 1 NC_009566.1 COG1629 Outer membrane receptor proteins, mostly Fe transport; heme-hemopexin utilization protein C 332355 5224779 CGSHiEE_01745 Haemophilus influenzae PittEE heme-hemopexin utilization protein C YP_001290212.1 330193 R 374930 CDS YP_001290213.1 148825460 5224780 333797..334522 1 NC_009566.1 catalyzes the phosphorylation of 3-deoxy-D-manno-octulosonic acid at the 4-OH position; 3-deoxy-D-manno-octulosonic-acid kinase 334522 5224780 CGSHiEE_01760 Haemophilus influenzae PittEE 3-deoxy-D-manno-octulosonic-acid kinase YP_001290213.1 333797 D 374930 CDS YP_001290214.1 148825461 5224781 334534..335121 1 NC_009566.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 335121 5224781 CGSHiEE_01765 Haemophilus influenzae PittEE putative deoxyribonucleotide triphosphate pyrophosphatase YP_001290214.1 334534 D 374930 CDS YP_001290215.1 148825462 5224782 335179..336018 1 NC_009566.1 UDP-galactose--lipooligosaccharide galactosyltransferase 336018 5224782 CGSHiEE_01770 Haemophilus influenzae PittEE UDP-galactose--lipooligosaccharide galactosyltransferase YP_001290215.1 335179 D 374930 CDS YP_001290216.1 148825463 5224783 336011..336133 1 NC_009566.1 COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases; hypothetical protein 336133 5224783 CGSHiEE_01775 Haemophilus influenzae PittEE hypothetical protein YP_001290216.1 336011 D 374930 CDS YP_001290217.1 148825464 5224773 complement(336544..336867) 1 NC_009566.1 COG1544 Ribosome-associated protein Y (PSrp-1); hypothetical protein 336867 5224773 CGSHiEE_01780 Haemophilus influenzae PittEE hypothetical protein YP_001290217.1 336544 R 374930 CDS YP_001290218.1 148825465 5224774 complement(337040..337672) 1 NC_009566.1 COG3317 Uncharacterized lipoprotein; putative deoxyribonucleotide triphosphate pyrophosphatase 337672 5224774 CGSHiEE_01785 Haemophilus influenzae PittEE putative deoxyribonucleotide triphosphate pyrophosphatase YP_001290218.1 337040 R 374930 CDS YP_001290219.1 148825466 5224775 complement(337798..338694) 1 NC_009566.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 338694 5224775 CGSHiEE_01790 Haemophilus influenzae PittEE dihydrodipicolinate synthase YP_001290219.1 337798 R 374930 CDS YP_001290220.1 148825467 5224776 338795..339262 1 NC_009566.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 339262 bcp 5224776 bcp Haemophilus influenzae PittEE thioredoxin-dependent thiol peroxidase YP_001290220.1 338795 D 374930 CDS YP_001290221.1 148825468 5224777 339405..339857 1 NC_009566.1 COG0811 Biopolymer transport proteins; transport protein ExbB 339857 5224777 CGSHiEE_01800 Haemophilus influenzae PittEE transport protein ExbB YP_001290221.1 339405 D 374930 CDS YP_001290222.1 148825469 5224778 339861..340304 1 NC_009566.1 COG0848 Biopolymer transport protein; biopolymer transport protein 340304 5224778 CGSHiEE_01805 Haemophilus influenzae PittEE biopolymer transport protein YP_001290222.1 339861 D 374930 CDS YP_001290223.1 148825470 5224742 340314..341105 1 NC_009566.1 COG0810 Periplasmic protein TonB, links inner and outer membranes; TonB 341105 bcp 5224742 bcp Haemophilus influenzae PittEE TonB YP_001290223.1 340314 D 374930 CDS YP_001290224.1 148825471 5224745 complement(341291..341797) 1 NC_009566.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 341797 5224745 CGSHiEE_01815 Haemophilus influenzae PittEE single-stranded DNA-binding protein YP_001290224.1 341291 R 374930 CDS YP_001290225.1 148825472 5225274 349563..350009 1 NC_009566.1 COG3468 Type V secretory pathway, adhesin AidA; hypothetical protein 350009 uvrA 5225274 uvrA Haemophilus influenzae PittEE hypothetical protein YP_001290225.1 349563 D 374930 CDS YP_001290226.1 148825473 5225275 350133..351224 1 NC_009566.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 351224 queA 5225275 queA Haemophilus influenzae PittEE S-adenosylmethionine:tRNA ribosyltransferase-isomerase YP_001290226.1 350133 D 374930 CDS YP_001290227.1 148825474 5225276 351569..352717 1 NC_009566.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 352717 tgt 5225276 tgt Haemophilus influenzae PittEE queuine tRNA-ribosyltransferase YP_001290227.1 351569 D 374930 CDS YP_001290228.1 148825475 5225099 352782..353300 1 NC_009566.1 COG0457 FOG: TPR repeat; hypothetical protein 353300 5225099 CGSHiEE_01860 Haemophilus influenzae PittEE hypothetical protein YP_001290228.1 352782 D 374930 CDS YP_001290229.1 148825476 5225100 353297..353518 1 NC_009566.1 COG0425 Predicted redox protein, regulator of disulfide bond formation; queuine tRNA-ribosyltransferase 353518 tgt 5225100 tgt Haemophilus influenzae PittEE queuine tRNA-ribosyltransferase YP_001290229.1 353297 D 374930 CDS YP_001290230.1 148825477 5225101 353626..353919 1 NC_009566.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 353919 yajC 5225101 yajC Haemophilus influenzae PittEE preprotein translocase subunit YajC YP_001290230.1 353626 D 374930 CDS YP_001290231.1 148825478 5225102 355849..356823 1 NC_009566.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 356823 secF 5225102 secF Haemophilus influenzae PittEE preprotein translocase subunit SecF YP_001290231.1 355849 D 374930 CDS YP_001290232.1 148825479 5225103 complement(356939..357988) 1 NC_009566.1 COG0628 Predicted permease; hypothetical protein 357988 5225103 CGSHiEE_01890 Haemophilus influenzae PittEE hypothetical protein YP_001290232.1 356939 R 374930 CDS YP_001290233.1 148825480 5225051 358066..358416 1 NC_009566.1 COG1393 Arsenate reductase and related proteins, glutaredoxin family; putative arsenate reductase 358416 5225051 CGSHiEE_01895 Haemophilus influenzae PittEE putative arsenate reductase YP_001290233.1 358066 D 374930 CDS YP_001290234.1 148825481 5225052 358484..358729 1 NC_009566.1 hypothetical protein 358729 5225052 CGSHiEE_01900 Haemophilus influenzae PittEE hypothetical protein YP_001290234.1 358484 D 374930 CDS YP_001290235.1 148825482 5225053 358749..359045 1 NC_009566.1 hypothetical protein 359045 5225053 CGSHiEE_01905 Haemophilus influenzae PittEE hypothetical protein YP_001290235.1 358749 D 374930 CDS YP_001290236.1 148825483 5225054 complement(359178..359330) 1 NC_009566.1 COG3036 Uncharacterized protein conserved in bacteria; hypothetical protein 359330 5225054 CGSHiEE_01910 Haemophilus influenzae PittEE hypothetical protein YP_001290236.1 359178 R 374930 CDS YP_001290237.1 148825484 5225055 complement(359335..360783) 1 NC_009566.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; putative transglycosylase 360783 5225055 CGSHiEE_01915 Haemophilus influenzae PittEE putative transglycosylase YP_001290237.1 359335 R 374930 CDS YP_001290238.1 148825485 5224997 complement(360901..362742) 1 NC_009566.1 COG0513 Superfamily II DNA and RNA helicases; preprotein translocase subunit SecF 362742 secF 5224997 secF Haemophilus influenzae PittEE preprotein translocase subunit SecF YP_001290238.1 360901 R 374930 CDS YP_001290239.1 148825486 5224998 complement(362921..363754) 1 NC_009566.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI 363754 5224998 CGSHiEE_01925 Haemophilus influenzae PittEE lipoprotein NlpI YP_001290239.1 362921 R 374930 CDS YP_001290240.1 148825487 5224999 complement(363935..366064) 1 NC_009566.1 COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase); polynucleotide phosphorylase/polyadenylase 366064 5224999 CGSHiEE_01930 Haemophilus influenzae PittEE polynucleotide phosphorylase/polyadenylase YP_001290240.1 363935 R 374930 CDS YP_001290241.1 148825488 5225000 366420..366938 1 NC_009566.1 COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases; hypothetical protein 366938 5225000 CGSHiEE_01935 Haemophilus influenzae PittEE hypothetical protein YP_001290241.1 366420 D 374930 CDS YP_001290242.1 148825489 5225001 367014..367481 1 NC_009566.1 COG2731 Beta-galactosidase, beta subunit; hypothetical protein 367481 5225001 CGSHiEE_01940 Haemophilus influenzae PittEE hypothetical protein YP_001290242.1 367014 D 374930 CDS YP_001290243.1 148825490 5225002 complement(367589..368932) 1 NC_009566.1 COG1114 Branched-chain amino acid permeases; branched-chain amino acid transport system II carrier protein 368932 5225002 CGSHiEE_01945 Haemophilus influenzae PittEE branched-chain amino acid transport system II carrier protein YP_001290243.1 367589 R 374930 CDS YP_001290244.1 148825491 5224991 369087..370289 1 NC_009566.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 370289 5224991 CGSHiEE_01950 Haemophilus influenzae PittEE pH-dependent sodium/proton antiporter YP_001290244.1 369087 D 374930 CDS YP_001290245.1 148825492 5224992 complement(370328..370789) 1 NC_009566.1 COG1522 Transcriptional regulators; putative transcriptional regulator 370789 5224992 CGSHiEE_01955 Haemophilus influenzae PittEE putative transcriptional regulator YP_001290245.1 370328 R 374930 CDS YP_001290246.1 148825493 5224993 370909..371799 1 NC_009566.1 COG2962 Predicted permeases; hypothetical protein 371799 5224993 CGSHiEE_01960 Haemophilus influenzae PittEE hypothetical protein YP_001290246.1 370909 D 374930 CDS YP_001290247.1 148825494 5224994 complement(371861..373432) 1 NC_009566.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 373432 guaA 5224994 guaA Haemophilus influenzae PittEE GMP synthase YP_001290247.1 371861 R 374930 CDS YP_001290248.1 148825495 5224995 complement(373542..375008) 1 NC_009566.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 375008 5224995 CGSHiEE_01970 Haemophilus influenzae PittEE inosine 5'-monophosphate dehydrogenase YP_001290248.1 373542 R 374930 CDS YP_001290249.1 148825496 5224996 375138..376043 1 NC_009566.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 376043 5224996 CGSHiEE_01975 Haemophilus influenzae PittEE biotin--protein ligase YP_001290249.1 375138 D 374930 CDS YP_001290250.1 148825497 5224766 382320..382712 1 NC_009566.1 COG3223 Predicted membrane protein; phosphate-starvation-inducible protein PsiE 382712 5224766 CGSHiEE_01980 Haemophilus influenzae PittEE phosphate-starvation-inducible protein PsiE YP_001290250.1 382320 D 374930 CDS YP_001290251.1 148825498 5224738 complement(382776..384062) 1 NC_009566.1 COG3071 Uncharacterized enzyme of heme biosynthesis; heme biosynthesis protein HemY 384062 5224738 CGSHiEE_01985 Haemophilus influenzae PittEE heme biosynthesis protein HemY YP_001290251.1 382776 R 374930 CDS YP_001290252.1 148825499 5224741 complement(384073..385284) 1 NC_009566.1 COG2959 Uncharacterized enzyme of heme biosynthesis; phosphate-starvation-inducible protein PsiE 385284 5224741 CGSHiEE_01990 Haemophilus influenzae PittEE phosphate-starvation-inducible protein PsiE YP_001290252.1 384073 R 374930 CDS YP_001290253.1 148825500 5226273 385590..388121 1 NC_009566.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 388121 cyaA 5226273 cyaA Haemophilus influenzae PittEE adenylate cyclase YP_001290253.1 385590 D 374930 CDS YP_001290254.1 148825501 5226274 388195..389202 1 NC_009566.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 389202 gpsA 5226274 gpsA Haemophilus influenzae PittEE NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_001290254.1 388195 D 374930 CDS YP_001290255.1 148825502 5226275 389219..390022 1 NC_009566.1 catalyzes the O-acetylation of serine; serine acetyltransferase 390022 cysE 5226275 cysE Haemophilus influenzae PittEE serine acetyltransferase YP_001290255.1 389219 D 374930 CDS YP_001290256.1 148825503 5226276 390032..390847 1 NC_009566.1 catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 390847 5226276 CGSHiEE_02010 Haemophilus influenzae PittEE shikimate 5-dehydrogenase YP_001290256.1 390032 D 374930 CDS YP_001290257.1 148825504 5226277 390985..392370 1 NC_009566.1 COG0471 Di- and tricarboxylate transporters; putative di- and tricarboxylate transporter 392370 5226277 CGSHiEE_02015 Haemophilus influenzae PittEE putative di- and tricarboxylate transporter YP_001290257.1 390985 D 374930 CDS YP_001290258.1 148825505 5226278 complement(392508..393356) 1 NC_009566.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 393356 5226278 CGSHiEE_02020 Haemophilus influenzae PittEE bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_001290258.1 392508 R 374930 CDS YP_001290259.1 148825506 5225327 complement(395211..395861) 1 NC_009566.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 395861 5225327 CGSHiEE_02035 Haemophilus influenzae PittEE L-fuculose phosphate aldolase YP_001290259.1 395211 R 374930 CDS YP_001290260.1 148825507 5225328 complement(395881..396315) 1 NC_009566.1 COG4154 Fucose dissimilation pathway protein FucU; L-fuculose phosphate aldolase 396315 5225328 CGSHiEE_02040 Haemophilus influenzae PittEE L-fuculose phosphate aldolase YP_001290260.1 395881 R 374930 CDS YP_001290261.1 148825508 5225329 complement(396330..397742) 1 NC_009566.1 COG1070 Sugar (pentulose and hexulose) kinases; L-fuculokinase 397742 5225329 CGSHiEE_02045 Haemophilus influenzae PittEE L-fuculokinase YP_001290261.1 396330 R 374930 CDS YP_001290262.1 148825509 5225330 complement(397815..399584) 1 NC_009566.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 399584 fucI 5225330 fucI Haemophilus influenzae PittEE L-fucose isomerase YP_001290262.1 397815 R 374930 CDS YP_001290263.1 148825510 5225244 complement(399814..400563) 1 NC_009566.1 COG1349 Transcriptional regulators of sugar metabolism; L-fucose isomerase 400563 fucI 5225244 fucI Haemophilus influenzae PittEE L-fucose isomerase YP_001290263.1 399814 R 374930 CDS YP_001290264.1 148825511 5225245 400761..403532 1 NC_009566.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA 403532 5225245 CGSHiEE_02060 Haemophilus influenzae PittEE ATP-dependent helicase HepA YP_001290264.1 400761 D 374930 CDS YP_001290265.1 148825512 5225203 403535..404194 1 NC_009566.1 COG0564 Pseudouridylate synthases, 23S RNA-specific; hypothetical protein 404194 5225203 CGSHiEE_02065 Haemophilus influenzae PittEE hypothetical protein YP_001290265.1 403535 D 374930 CDS YP_001290266.1 148825513 5225204 404221..404799 1 NC_009566.1 COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid); glp protein 404799 5225204 CGSHiEE_02070 Haemophilus influenzae PittEE glp protein YP_001290266.1 404221 D 374930 CDS YP_001290267.1 148825514 5225205 404829..405596 1 NC_009566.1 COG1349 Transcriptional regulators of sugar metabolism; glycerol-3-phosphate regulon repressor 405596 5225205 CGSHiEE_02075 Haemophilus influenzae PittEE glycerol-3-phosphate regulon repressor YP_001290267.1 404829 D 374930 CDS YP_001290268.1 148825515 5225206 complement(405898..406719) 1 NC_009566.1 COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen; putative D-methionine-binding lipoprotein MetQ 406719 5225206 CGSHiEE_02080 Haemophilus influenzae PittEE putative D-methionine-binding lipoprotein MetQ YP_001290268.1 405898 R 374930 CDS YP_001290269.1 148825516 5225207 complement(406758..407447) 1 NC_009566.1 COG2011 ABC-type metal ion transport system, permease component; ATP-dependent helicase HepA 407447 5225207 CGSHiEE_02085 Haemophilus influenzae PittEE ATP-dependent helicase HepA YP_001290269.1 406758 R 374930 CDS YP_001290270.1 148825517 5225208 complement(407437..408474) 1 NC_009566.1 part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit 408474 metN 5225208 metN Haemophilus influenzae PittEE DL-methionine transporter ATP-binding subunit YP_001290270.1 407437 R 374930 CDS YP_001290271.1 148825518 5225035 408650..409204 1 NC_009566.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 409204 5225035 CGSHiEE_02095 Haemophilus influenzae PittEE D,D-heptose 1,7-bisphosphate phosphatase YP_001290271.1 408650 D 374930 CDS YP_001290272.1 148825519 5225038 415139..415726 1 NC_009566.1 hypothetical protein 415726 5225038 CGSHiEE_02100 Haemophilus influenzae PittEE hypothetical protein YP_001290272.1 415139 D 374930 CDS YP_001290273.1 148825520 5225020 complement(422744..423898) 1 NC_009566.1 hypothetical protein 423898 5225020 CGSHiEE_02140 Haemophilus influenzae PittEE hypothetical protein YP_001290273.1 422744 R 374930 CDS YP_001290274.1 148825521 5224944 complement(423900..425051) 1 NC_009566.1 hypothetical protein 425051 5224944 CGSHiEE_02145 Haemophilus influenzae PittEE hypothetical protein YP_001290274.1 423900 R 374930 CDS YP_001290275.1 148825522 5224945 complement(425170..426714) 1 NC_009566.1 hypothetical protein 426714 5224945 CGSHiEE_02150 Haemophilus influenzae PittEE hypothetical protein YP_001290275.1 425170 R 374930 CDS YP_001290276.1 148825523 5224946 complement(426946..428985) 1 NC_009566.1 oligopeptidase A 428985 5224946 CGSHiEE_02155 Haemophilus influenzae PittEE oligopeptidase A YP_001290276.1 426946 R 374930 CDS YP_001290277.1 148825524 5224947 429110..429472 1 NC_009566.1 hypothetical protein 429472 5224947 CGSHiEE_02160 Haemophilus influenzae PittEE hypothetical protein YP_001290277.1 429110 D 374930 CDS YP_001290278.1 148825525 5224948 429465..431009 1 NC_009566.1 hypothetical protein 431009 5224948 CGSHiEE_02165 Haemophilus influenzae PittEE hypothetical protein YP_001290278.1 429465 D 374930 CDS YP_001290279.1 148825526 5224934 complement(431326..431976) 1 NC_009566.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 431976 ribA 5224934 ribA Haemophilus influenzae PittEE GTP cyclohydrolase II YP_001290279.1 431326 R 374930 CDS YP_001290280.1 148825527 5224935 432080..432769 1 NC_009566.1 phosphatidylglycerophosphatase B 432769 5224935 CGSHiEE_02175 Haemophilus influenzae PittEE phosphatidylglycerophosphatase B YP_001290280.1 432080 D 374930 CDS YP_001290281.1 148825528 5224936 complement(432788..432895) 1 NC_009566.1 hypothetical protein 432895 5224936 CGSHiEE_02180 Haemophilus influenzae PittEE hypothetical protein YP_001290281.1 432788 R 374930 CDS YP_001290282.1 148825529 5224937 complement(434719..435807) 1 NC_009566.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 435807 aroB 5224937 aroB Haemophilus influenzae PittEE 3-dehydroquinate synthase YP_001290282.1 434719 R 374930 CDS YP_001290283.1 148825530 5224929 complement(435827..436369) 1 NC_009566.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 436369 aroK 5224929 aroK Haemophilus influenzae PittEE shikimate kinase YP_001290283.1 435827 R 374930 CDS YP_001290284.1 148825531 5224930 complement(436656..438467) 1 NC_009566.1 NAD nucleotidase 438467 5224930 CGSHiEE_02210 Haemophilus influenzae PittEE NAD nucleotidase YP_001290284.1 436656 R 374930 CDS YP_001290285.1 148825532 5224931 439557..439805 1 NC_009566.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 439805 rpsP 5224931 rpsP Haemophilus influenzae PittEE 30S ribosomal protein S16 YP_001290285.1 439557 D 374930 CDS YP_001290286.1 148825533 5224932 439851..440378 1 NC_009566.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 440378 rimM 5224932 rimM Haemophilus influenzae PittEE 16S rRNA-processing protein RimM YP_001290286.1 439851 D 374930 CDS YP_001290287.1 148825534 5224933 440416..441156 1 NC_009566.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 441156 trmD 5224933 trmD Haemophilus influenzae PittEE tRNA (guanine-N(1)-)-methyltransferase YP_001290287.1 440416 D 374930 CDS YP_001290288.1 148825535 5224824 441193..441543 1 NC_009566.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 441543 rplS 5224824 rplS Haemophilus influenzae PittEE 50S ribosomal protein L19 YP_001290288.1 441193 D 374930 CDS YP_001290289.1 148825536 5224825 complement(442751..443608) 1 NC_009566.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 443608 5224825 CGSHiEE_02255 Haemophilus influenzae PittEE lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_001290289.1 442751 R 374930 CDS YP_001290290.1 148825537 5224826 complement(443755..444522) 1 NC_009566.1 COG0730 Predicted permeases; hypothetical protein 444522 5224826 CGSHiEE_02260 Haemophilus influenzae PittEE hypothetical protein YP_001290290.1 443755 R 374930 CDS YP_001290291.1 148825538 5224827 complement(444540..445400) 1 NC_009566.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 445400 mepA 5224827 mepA Haemophilus influenzae PittEE penicillin-insensitive murein endopeptidase YP_001290291.1 444540 R 374930 CDS YP_001290292.1 148825539 5224828 complement(445572..446645) 1 NC_009566.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 446645 5224828 CGSHiEE_02270 Haemophilus influenzae PittEE chorismate synthase YP_001290292.1 445572 R 374930 CDS YP_001290293.1 148825540 5224809 complement(446655..449975) 1 NC_009566.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 449975 5224809 CGSHiEE_02275 Haemophilus influenzae PittEE potassium efflux protein KefA YP_001290293.1 446655 R 374930 CDS YP_001290294.1 148825541 5224810 complement(450017..451375) 1 NC_009566.1 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; O-succinylbenzoic acid--CoA ligase 451375 5224810 CGSHiEE_02280 Haemophilus influenzae PittEE O-succinylbenzoic acid--CoA ligase YP_001290294.1 450017 R 374930 CDS YP_001290295.1 148825542 5224811 452043..452825 1 NC_009566.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); esterase/lipase 452825 5224811 CGSHiEE_02295 Haemophilus influenzae PittEE esterase/lipase YP_001290295.1 452043 D 374930 CDS YP_001290296.1 148825543 5224812 452922..453446 1 NC_009566.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA 453446 5224812 CGSHiEE_02300 Haemophilus influenzae PittEE flavodoxin FldA YP_001290296.1 452922 D 374930 CDS YP_001290297.1 148825544 5224813 453475..453915 1 NC_009566.1 COG0735 Fe2+/Zn2+ uptake regulation proteins; ferric uptake regulation protein 453915 5224813 CGSHiEE_02305 Haemophilus influenzae PittEE ferric uptake regulation protein YP_001290297.1 453475 D 374930 CDS YP_001290298.1 148825545 5224784 complement(454023..455372) 1 NC_009566.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 455372 5224784 CGSHiEE_02310 Haemophilus influenzae PittEE glutamate dehydrogenase YP_001290298.1 454023 R 374930 CDS YP_001290299.1 148825546 5224785 complement(455731..456501) 1 NC_009566.1 COG0805 Sec-independent protein secretion pathway component TatC; Sec-independent protein translocase protein TatC 456501 5224785 CGSHiEE_02315 Haemophilus influenzae PittEE Sec-independent protein translocase protein TatC YP_001290299.1 455731 R 374930 CDS YP_001290300.1 148825547 5224786 complement(456511..457071) 1 NC_009566.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 457071 5224786 CGSHiEE_02320 Haemophilus influenzae PittEE sec-independent translocase YP_001290300.1 456511 R 374930 CDS YP_001290301.1 148825548 5224787 complement(457075..457302) 1 NC_009566.1 COG1826 Sec-independent protein secretion pathway components; Sec-independent protein translocase protein TatA/E 457302 5224787 CGSHiEE_02325 Haemophilus influenzae PittEE Sec-independent protein translocase protein TatA/E YP_001290301.1 457075 R 374930 CDS YP_001290302.1 148825549 5224788 complement(457519..457926) 1 NC_009566.1 COG0789 Predicted transcriptional regulators; putative HTH-type transcriptional regulator 457926 5224788 CGSHiEE_02330 Haemophilus influenzae PittEE putative HTH-type transcriptional regulator YP_001290302.1 457519 R 374930 CDS YP_001290303.1 148825550 5224789 458048..459184 1 NC_009566.1 COG1062 Zn-dependent alcohol dehydrogenases, class III; alcohol dehydrogenase class III 459184 5224789 CGSHiEE_02335 Haemophilus influenzae PittEE alcohol dehydrogenase class III YP_001290303.1 458048 D 374930 CDS YP_001290304.1 148825551 5225287 459193..460020 1 NC_009566.1 COG0627 Predicted esterase; esterase 460020 5225287 CGSHiEE_02340 Haemophilus influenzae PittEE esterase YP_001290304.1 459193 D 374930 CDS YP_001290305.1 148825552 5225288 466752..468095 1 NC_009566.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit A 468095 5225288 CGSHiEE_02355 Haemophilus influenzae PittEE Na(+)-translocating NADH-quinone reductase subunit A YP_001290305.1 466752 D 374930 CDS YP_001290306.1 148825553 5225289 468098..469333 1 NC_009566.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit B 469333 5225289 CGSHiEE_02360 Haemophilus influenzae PittEE Na(+)-translocating NADH-quinone reductase subunit B YP_001290306.1 468098 D 374930 CDS YP_001290307.1 148825554 5225290 469326..470060 1 NC_009566.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit C 470060 5225290 CGSHiEE_02365 Haemophilus influenzae PittEE Na(+)-translocating NADH-quinone reductase subunit C YP_001290307.1 469326 D 374930 CDS YP_001290308.1 148825555 5225256 470060..470686 1 NC_009566.1 Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit D 470686 5225256 CGSHiEE_02370 Haemophilus influenzae PittEE Na(+)-translocating NADH-quinone reductase subunit D YP_001290308.1 470060 D 374930 CDS YP_001290309.1 148825556 5225257 470690..471286 1 NC_009566.1 Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.; Na(+)-translocating NADH-quinone reductase subunit E 471286 5225257 CGSHiEE_02375 Haemophilus influenzae PittEE Na(+)-translocating NADH-quinone reductase subunit E YP_001290309.1 470690 D 374930 CDS YP_001290310.1 148825557 5225258 471299..472534 1 NC_009566.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit F 472534 5225258 CGSHiEE_02380 Haemophilus influenzae PittEE Na(+)-translocating NADH-quinone reductase subunit F YP_001290310.1 471299 D 374930 CDS YP_001290311.1 148825558 5225259 472678..473718 1 NC_009566.1 COG1477 Membrane-associated lipoprotein involved in thiamine biosynthesis; lipoprotein 473718 5225259 CGSHiEE_02385 Haemophilus influenzae PittEE lipoprotein YP_001290311.1 472678 D 374930 CDS YP_001290312.1 148825559 5225260 473721..473981 1 NC_009566.1 COG2991 Uncharacterized protein conserved in bacteria; hypothetical protein 473981 5225260 CGSHiEE_02390 Haemophilus influenzae PittEE hypothetical protein YP_001290312.1 473721 D 374930 CDS YP_001290313.1 148825560 5225261 complement(475293..476027) 1 NC_009566.1 COG1496 Uncharacterized conserved protein; hypothetical protein 476027 trmU 5225261 trmU Haemophilus influenzae PittEE hypothetical protein YP_001290313.1 475293 R 374930 CDS YP_001290314.1 148825561 5225246 complement(476029..477003) 1 NC_009566.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D 477003 rluD 5225246 rluD Haemophilus influenzae PittEE 23S rRNA pseudouridine synthase D YP_001290314.1 476029 R 374930 CDS YP_001290315.1 148825562 5225247 477111..477899 1 NC_009566.1 COG4105 DNA uptake lipoprotein; hypothetical protein 477899 5225247 CGSHiEE_02415 Haemophilus influenzae PittEE hypothetical protein YP_001290315.1 477111 D 374930 CDS YP_001290316.1 148825563 5225248 complement(479357..481669) 1 NC_009566.1 COG1882 Pyruvate-formate lyase; formate acetyltransferase 481669 5225248 CGSHiEE_02440 Haemophilus influenzae PittEE formate acetyltransferase YP_001290316.1 479357 R 374930 CDS YP_001290317.1 148825564 5225249 complement(481707..482561) 1 NC_009566.1 COG2116 Formate/nitrite family of transporters; putative formate transporter 482561 5225249 CGSHiEE_02445 Haemophilus influenzae PittEE putative formate transporter YP_001290317.1 481707 R 374930 CDS YP_001290318.1 148825565 5225164 483065..483979 1 NC_009566.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 483979 5225164 CGSHiEE_02450 Haemophilus influenzae PittEE N-acetyl-D-glucosamine kinase YP_001290318.1 483065 D 374930 CDS YP_001290319.1 148825566 5225165 484012..484155 1 NC_009566.1 COG1940 Transcriptional regulator/sugar kinase; hypothetical protein 484155 5225165 CGSHiEE_02455 Haemophilus influenzae PittEE hypothetical protein YP_001290319.1 484012 D 374930 CDS YP_001290320.1 148825567 5225166 484165..485604 1 NC_009566.1 COG1115 Na+/alanine symporter; putative Na+/alanine symporter 485604 5225166 CGSHiEE_02460 Haemophilus influenzae PittEE putative Na+/alanine symporter YP_001290320.1 484165 D 374930 CDS YP_001290321.1 148825568 5225167 complement(486375..486725) 1 NC_009566.1 COG0271 Stress-induced morphogen (activity unknown); transcriptional regulator 486725 5225167 CGSHiEE_02465 Haemophilus influenzae PittEE transcriptional regulator YP_001290321.1 486375 R 374930 CDS YP_001290322.1 148825569 5225168 486819..487418 1 NC_009566.1 COG3056 Uncharacterized lipoprotein; pyruvate formate lyase-activating enzyme 1 487418 pflA 5225168 pflA Haemophilus influenzae PittEE pyruvate formate lyase-activating enzyme 1 YP_001290322.1 486819 D 374930 CDS YP_001290323.1 148825570 5225169 487635..489005 1 NC_009566.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 489005 5225169 CGSHiEE_02475 Haemophilus influenzae PittEE glutathione reductase YP_001290323.1 487635 D 374930 CDS YP_001290324.1 148825571 5225143 complement(489114..489983) 1 NC_009566.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 489983 psd 5225143 psd Haemophilus influenzae PittEE phosphatidylserine decarboxylase YP_001290324.1 489114 R 374930 CDS YP_001290325.1 148825572 5225144 490143..490646 1 NC_009566.1 COG1399 Predicted metal-binding, possibly nucleic acid-binding protein; hypothetical protein 490646 5225144 CGSHiEE_02485 Haemophilus influenzae PittEE hypothetical protein YP_001290325.1 490143 D 374930 CDS YP_001290326.1 148825573 5225145 490689..490859 1 NC_009566.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 490859 rpmF 5225145 rpmF Haemophilus influenzae PittEE 50S ribosomal protein L32 YP_001290326.1 490689 D 374930 CDS YP_001290327.1 148825574 5225146 490909..491010 1 NC_009566.1 COG0333 Ribosomal protein L32; hypothetical protein 491010 5225146 CGSHiEE_02495 Haemophilus influenzae PittEE hypothetical protein YP_001290327.1 490909 D 374930 CDS YP_001290328.1 148825575 5225147 491119..492012 1 NC_009566.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III 492012 5225147 CGSHiEE_02500 Haemophilus influenzae PittEE 3-oxoacyl-(acyl carrier protein) synthase III YP_001290328.1 491119 D 374930 CDS YP_001290329.1 148825576 5225148 492625..493563 1 NC_009566.1 COG0331 (acyl-carrier-protein) S-malonyltransferase; acyl carrier protein S-malonyltransferase 493563 5225148 CGSHiEE_02505 Haemophilus influenzae PittEE acyl carrier protein S-malonyltransferase YP_001290329.1 492625 D 374930 CDS YP_001290330.1 148825577 5225120 493580..494308 1 NC_009566.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 494308 fabG 5225120 fabG Haemophilus influenzae PittEE 3-ketoacyl-(acyl-carrier-protein) reductase YP_001290330.1 493580 D 374930 CDS YP_001290331.1 148825578 5225121 494563..494793 1 NC_009566.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 494793 acpP 5225121 acpP Haemophilus influenzae PittEE acyl carrier protein YP_001290331.1 494563 D 374930 CDS YP_001290332.1 148825579 5225122 494997..496328 1 NC_009566.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter 496328 5225122 CGSHiEE_02520 Haemophilus influenzae PittEE anaerobic C4-dicarboxylate transporter YP_001290332.1 494997 D 374930 CDS YP_001290333.1 148825580 5225123 496388..496987 1 NC_009566.1 COG2091 Phosphopantetheinyl transferase; putative 4'-phosphopantetheinyl transferase 496987 5225123 CGSHiEE_02525 Haemophilus influenzae PittEE putative 4'-phosphopantetheinyl transferase YP_001290333.1 496388 D 374930 CDS YP_001290334.1 148825581 5225124 497216..498436 1 NC_009566.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs; FtsH protease regulator HflK 498436 5225124 CGSHiEE_02530 Haemophilus influenzae PittEE FtsH protease regulator HflK YP_001290334.1 497216 D 374930 CDS YP_001290335.1 148825582 5225045 498436..499323 1 NC_009566.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs; hypothetical protein 499323 5225045 CGSHiEE_02535 Haemophilus influenzae PittEE hypothetical protein YP_001290335.1 498436 D 374930 CDS YP_001290336.1 148825583 5225046 complement(499366..499800) 1 NC_009566.1 COG2020 Putative protein-S-isoprenylcysteine methyltransferase; putative protein-S-isoprenylcysteine methyltransferase 499800 5225046 CGSHiEE_02540 Haemophilus influenzae PittEE putative protein-S-isoprenylcysteine methyltransferase YP_001290336.1 499366 R 374930 CDS YP_001290337.1 148825584 5225047 complement(499962..501089) 1 NC_009566.1 COG3055 Uncharacterized protein conserved in bacteria; N-acetylneuraminic acid mutarotase 501089 5225047 CGSHiEE_02545 Haemophilus influenzae PittEE N-acetylneuraminic acid mutarotase YP_001290337.1 499962 R 374930 CDS YP_001290338.1 148825585 5225048 complement(501265..503115) 1 NC_009566.1 COG3090 TRAP-type C4-dicarboxylate transport system, small permease component; hypothetical protein 503115 5225048 CGSHiEE_02550 Haemophilus influenzae PittEE hypothetical protein YP_001290338.1 501265 R 374930 CDS YP_001290339.1 148825586 5225049 complement(503180..504076) 1 NC_009566.1 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component; anaerobic C4-dicarboxylate transporter 504076 5225049 CGSHiEE_02555 Haemophilus influenzae PittEE anaerobic C4-dicarboxylate transporter YP_001290339.1 503180 R 374930 CDS YP_001290340.1 148825587 5225050 504520..505206 1 NC_009566.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 505206 5225050 CGSHiEE_02560 Haemophilus influenzae PittEE N-acetylmannosamine-6-phosphate 2-epimerase YP_001290340.1 504520 D 374930 CDS YP_001290341.1 148825588 5225025 505251..506153 1 NC_009566.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 506153 5225025 CGSHiEE_02565 Haemophilus influenzae PittEE N-acetylmannosamine kinase YP_001290341.1 505251 D 374930 CDS YP_001290342.1 148825589 5225026 506146..507012 1 NC_009566.1 COG1737 Transcriptional regulators; N-acetylmannosamine kinase 507012 5225026 CGSHiEE_02570 Haemophilus influenzae PittEE N-acetylmannosamine kinase YP_001290342.1 506146 D 374930 CDS YP_001290343.1 148825590 5225027 507023..507904 1 NC_009566.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 507904 5225027 CGSHiEE_02575 Haemophilus influenzae PittEE N-acetylneuraminate lyase YP_001290343.1 507023 D 374930 CDS YP_001290344.1 148825591 5225028 508189..509001 1 NC_009566.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 509001 nagB 5225028 nagB Haemophilus influenzae PittEE glucosamine-6-phosphate deaminase YP_001290344.1 508189 D 374930 CDS YP_001290345.1 148825592 5225029 509138..510283 1 NC_009566.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 510283 nagA 5225029 nagA Haemophilus influenzae PittEE N-acetylglucosamine-6-phosphate deacetylase YP_001290345.1 509138 D 374930 CDS YP_001290346.1 148825593 5225030 complement(510483..511541) 1 NC_009566.1 COG3203 Outer membrane protein (porin); N-acetylglucosamine-6-phosphate deacetylase 511541 nagA 5225030 nagA Haemophilus influenzae PittEE N-acetylglucosamine-6-phosphate deacetylase YP_001290346.1 510483 R 374930 CDS YP_001290347.1 148825594 5224976 complement(511973..512326) 1 NC_009566.1 COG0328 Ribonuclease HI; ribonuclease H 512326 rnhA 5224976 rnhA Haemophilus influenzae PittEE ribonuclease H YP_001290347.1 511973 R 374930 CDS YP_001290348.1 148825595 5224977 512327..513097 1 NC_009566.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 513097 5224977 CGSHiEE_02600 Haemophilus influenzae PittEE DNA polymerase III subunit epsilon YP_001290348.1 512327 D 374930 CDS YP_001290349.1 148825596 5224978 513780..515294 1 NC_009566.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 515294 engA 5224978 engA Haemophilus influenzae PittEE GTP-binding protein EngA YP_001290349.1 513780 D 374930 CDS YP_001290350.1 148825597 5224979 complement(517743..518330) 1 NC_009566.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 518330 dcd 5224979 dcd Haemophilus influenzae PittEE deoxycytidine triphosphate deaminase YP_001290350.1 517743 R 374930 CDS YP_001290351.1 148825598 5224980 complement(518339..518980) 1 NC_009566.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 518980 5224980 CGSHiEE_02635 Haemophilus influenzae PittEE uridine kinase YP_001290351.1 518339 R 374930 CDS YP_001290352.1 148825599 5224911 520752..521282 1 NC_009566.1 inorganic pyrophosphatase 521282 5224911 CGSHiEE_02645 Haemophilus influenzae PittEE inorganic pyrophosphatase YP_001290352.1 520752 D 374930 CDS YP_001290354.1 148825601 5224913 complement(521846..522184) 1 NC_009566.1 COG0558 Phosphatidylglycerophosphate synthase; uridine kinase 522184 5224913 CGSHiEE_02655 Haemophilus influenzae PittEE uridine kinase YP_001290354.1 521846 R 374930 CDS YP_001290355.1 148825602 5224814 522676..523866 1 NC_009566.1 catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 523866 5224814 CGSHiEE_02660 Haemophilus influenzae PittEE cystathionine beta-lyase YP_001290355.1 522676 D 374930 CDS YP_001290356.1 148825603 5224815 complement(523915..524034) 1 NC_009566.1 COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases; hypothetical protein 524034 5224815 CGSHiEE_02665 Haemophilus influenzae PittEE hypothetical protein YP_001290356.1 523915 R 374930 CDS YP_001290357.1 148825604 5224816 524344..525705 1 NC_009566.1 COG0773 UDP-N-acetylmuramate-alanine ligase; UDP-N-acetylmuramoylalanine-D-glutamate ligase-like protein 525705 5224816 CGSHiEE_02670 Haemophilus influenzae PittEE UDP-N-acetylmuramoylalanine-D-glutamate ligase-like protein YP_001290357.1 524344 D 374930 CDS YP_001290358.1 148825605 5224817 525818..526324 1 NC_009566.1 COG5413 Uncharacterized integral membrane protein; hypothetical protein 526324 5224817 CGSHiEE_02675 Haemophilus influenzae PittEE hypothetical protein YP_001290358.1 525818 D 374930 CDS YP_001290359.1 148825606 5224818 complement(526374..527375) 1 NC_009566.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic component 527375 znuA 5224818 znuA Haemophilus influenzae PittEE high-affinity zinc transporter periplasmic component YP_001290359.1 526374 R 374930 CDS YP_001290360.1 148825607 5224790 complement(527553..528338) 1 NC_009566.1 COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1; high-affinity zinc transporter periplasmic component 528338 znuA 5224790 znuA Haemophilus influenzae PittEE high-affinity zinc transporter periplasmic component YP_001290360.1 527553 R 374930 CDS YP_001290361.1 148825608 5224791 complement(528323..529432) 1 NC_009566.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A 529432 mltA 5224791 mltA Haemophilus influenzae PittEE murein transglycosylase A YP_001290361.1 528323 R 374930 CDS YP_001290362.1 148825609 5224792 529827..531962 1 NC_009566.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 531962 rlmL 5224792 rlmL Haemophilus influenzae PittEE 23S rRNA m(2)G2445 methyltransferase YP_001290362.1 529827 D 374930 CDS YP_001290363.1 148825610 5225979 538668..538772 1 NC_009566.1 COG0116 Predicted N6-adenine-specific DNA methylase; hypothetical protein 538772 5225979 CGSHiEE_02700 Haemophilus influenzae PittEE hypothetical protein YP_001290363.1 538668 D 374930 CDS YP_001290364.1 148825611 5225235 541806..541961 1 NC_009566.1 COG2801 Transposase and inactivated derivatives; transposase 541961 5225235 CGSHiEE_02715 Haemophilus influenzae PittEE transposase YP_001290364.1 541806 D 374930 CDS YP_001290365.1 148825612 5225188 complement(542009..542638) 1 NC_009566.1 COG0625 Glutathione S-transferase; methyltransferase 542638 5225188 CGSHiEE_02720 Haemophilus influenzae PittEE methyltransferase YP_001290365.1 542009 R 374930 CDS YP_001290366.1 148825613 5225189 complement(542973..544262) 1 NC_009566.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 544262 5225189 CGSHiEE_02725 Haemophilus influenzae PittEE seryl-tRNA synthetase YP_001290366.1 542973 R 374930 CDS YP_001290367.1 148825614 5225190 544535..544660 1 NC_009566.1 COG0172 Seryl-tRNA synthetase; hypothetical protein 544660 5225190 CGSHiEE_02730 Haemophilus influenzae PittEE hypothetical protein YP_001290367.1 544535 D 374930 CDS YP_001290368.1 148825615 5225191 complement(544614..545357) 1 NC_009566.1 COG2966 Uncharacterized conserved protein; hypothetical protein 545357 5225191 CGSHiEE_02735 Haemophilus influenzae PittEE hypothetical protein YP_001290368.1 544614 R 374930 CDS YP_001290369.1 148825616 5225192 complement(545485..546747) 1 NC_009566.1 COG4536 Putative Mg2+ and Co2+ transporter CorB; putative Mg2+ and Co2+ transporter 546747 5225192 CGSHiEE_02740 Haemophilus influenzae PittEE putative Mg2+ and Co2+ transporter YP_001290369.1 545485 R 374930 CDS YP_001290370.1 148825617 5225193 547028..548407 1 NC_009566.1 COG0541 Signal recognition particle GTPase; Signal recognition particle protein 548407 5225193 CGSHiEE_02745 Haemophilus influenzae PittEE Signal recognition particle protein YP_001290370.1 547028 D 374930 CDS YP_001290371.1 148825618 5225170 complement(548632..551628) 1 NC_009566.1 COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases; putative type I site-specific restriction-modification system, R subunit 551628 5225170 CGSHiEE_02750 Haemophilus influenzae PittEE putative type I site-specific restriction-modification system, R subunit YP_001290371.1 548632 R 374930 CDS YP_001290372.1 148825619 5225171 complement(551761..552837) 1 NC_009566.1 COG0732 Restriction endonuclease S subunits; putative type I site-specific restriction-modification system, S subunit 552837 5225171 CGSHiEE_02755 Haemophilus influenzae PittEE putative type I site-specific restriction-modification system, S subunit YP_001290372.1 551761 R 374930 CDS YP_001290373.1 148825620 5225172 complement(553219..554682) 1 NC_009566.1 COG2865 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen; transcription regulator 554682 5225172 CGSHiEE_02760 Haemophilus influenzae PittEE transcription regulator YP_001290373.1 553219 R 374930 CDS YP_001290374.1 148825621 5225173 complement(554809..557181) 1 NC_009566.1 COG0286 Type I restriction-modification system methyltransferase subunit; putative type I restriction-modification system, methyltransferase subunit 557181 5225173 CGSHiEE_02765 Haemophilus influenzae PittEE putative type I restriction-modification system, methyltransferase subunit YP_001290374.1 554809 R 374930 CDS YP_001290375.1 148825622 5225174 complement(557357..558112) 1 NC_009566.1 COG0327 Uncharacterized conserved protein; seryl-tRNA synthetase 558112 5225174 CGSHiEE_02770 Haemophilus influenzae PittEE seryl-tRNA synthetase YP_001290375.1 557357 R 374930 CDS YP_001290376.1 148825623 5225175 558424..560304 1 NC_009566.1 molecular chaperone; heat shock protein 90 560304 5225175 CGSHiEE_02775 Haemophilus influenzae PittEE heat shock protein 90 YP_001290376.1 558424 D 374930 CDS YP_001290377.1 148825624 5224981 560383..560727 1 NC_009566.1 COG1393 Arsenate reductase and related proteins, glutaredoxin family; heat shock protein 90 560727 5224981 CGSHiEE_02780 Haemophilus influenzae PittEE heat shock protein 90 YP_001290377.1 560383 D 374930 CDS YP_001290378.1 148825625 5224982 560755..561888 1 NC_009566.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 561888 5224982 CGSHiEE_02785 Haemophilus influenzae PittEE succinyl-diaminopimelate desuccinylase YP_001290378.1 560755 D 374930 CDS YP_001290379.1 148825626 5224983 561890..562570 1 NC_009566.1 COG1876 D-alanyl-D-alanine carboxypeptidase; putative D-alanyl-D-alanine carboxypeptidase 562570 5224983 CGSHiEE_02790 Haemophilus influenzae PittEE putative D-alanyl-D-alanine carboxypeptidase YP_001290379.1 561890 D 374930 CDS YP_001290380.1 148825627 5224984 complement(562605..563675) 1 NC_009566.1 COG3842 ABC-type spermidine/putrescine transport systems, ATPase components; iron(III) ABC transporter ATP-binding protein 563675 5224984 CGSHiEE_02795 Haemophilus influenzae PittEE iron(III) ABC transporter ATP-binding protein YP_001290380.1 562605 R 374930 CDS YP_001290381.1 148825628 5224985 complement(565301..566299) 1 NC_009566.1 iron-utilization periplasmic protein hFbpA 566299 5224985 CGSHiEE_02810 Haemophilus influenzae PittEE iron-utilization periplasmic protein hFbpA YP_001290381.1 565301 R 374930 CDS YP_001290382.1 148825629 5224900 complement(566451..566732) 1 NC_009566.1 COG1840 ABC-type Fe3+ transport system, periplasmic component; hypothetical protein 566732 5224900 CGSHiEE_02815 Haemophilus influenzae PittEE hypothetical protein YP_001290382.1 566451 R 374930 CDS YP_001290383.1 148825630 5224901 566933..567688 1 NC_009566.1 COG0500 SAM-dependent methyltransferases; hypothetical protein 567688 5224901 CGSHiEE_02820 Haemophilus influenzae PittEE hypothetical protein YP_001290383.1 566933 D 374930 CDS YP_001290384.1 148825631 5224902 567988..568785 1 NC_009566.1 COG2610 H+/gluconate symporter and related permeases; hypothetical protein 568785 5224902 CGSHiEE_02825 Haemophilus influenzae PittEE hypothetical protein YP_001290384.1 567988 D 374930 CDS YP_001290385.1 148825632 5224903 568794..569930 1 NC_009566.1 COG1929 Glycerate kinase; hypothetical protein 569930 5224903 CGSHiEE_02830 Haemophilus influenzae PittEE hypothetical protein YP_001290385.1 568794 D 374930 CDS YP_001290386.1 148825633 5224904 complement(569970..570683) 1 NC_009566.1 COG0325 Predicted enzyme with a TIM-barrel fold; hypothetical protein 570683 5224904 CGSHiEE_02835 Haemophilus influenzae PittEE hypothetical protein YP_001290386.1 569970 R 374930 CDS YP_001290387.1 148825634 5224819 571007..573454 1 NC_009566.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 573454 thrA 5224819 thrA Haemophilus influenzae PittEE bifunctional aspartokinase I/homoserine dehydrogenase I YP_001290387.1 571007 D 374930 CDS YP_001290388.1 148825635 5224820 573467..574411 1 NC_009566.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 574411 5224820 CGSHiEE_02845 Haemophilus influenzae PittEE homoserine kinase YP_001290388.1 573467 D 374930 CDS YP_001290389.1 148825636 5224821 574454..575731 1 NC_009566.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 575731 5224821 CGSHiEE_02850 Haemophilus influenzae PittEE threonine synthase YP_001290389.1 574454 D 374930 CDS YP_001290390.1 148825637 5224822 576581..577690 1 NC_009566.1 catalyzes the formation of cysteine from cystathionine; in B. subtilis also has O-acetylhomoserine thiolyase activity; cystathionine gamma-synthase 577690 5224822 CGSHiEE_02855 Haemophilus influenzae PittEE cystathionine gamma-synthase YP_001290390.1 576581 D 374930 CDS YP_001290391.1 148825638 5224823 578818..579141 1 NC_009566.1 COG0526 Thiol-disulfide isomerase and thioredoxins; thioredoxin 579141 5224823 CGSHiEE_02870 Haemophilus influenzae PittEE thioredoxin YP_001290391.1 578818 D 374930 CDS YP_001290392.1 148825639 5225417 complement(579191..579442) 1 NC_009566.1 hypothetical protein 579442 5225417 CGSHiEE_02875 Haemophilus influenzae PittEE hypothetical protein YP_001290392.1 579191 R 374930 CDS YP_001290393.1 148825640 5225418 complement(579495..579734) 1 NC_009566.1 COG0620 Methionine synthase II (cobalamin-independent); hypothetical protein 579734 5225418 CGSHiEE_02880 Haemophilus influenzae PittEE hypothetical protein YP_001290393.1 579495 R 374930 CDS YP_001290394.1 148825641 5225419 complement(579796..580584) 1 NC_009566.1 COG0084 Mg-dependent DNase; putative deoxyribonuclease 580584 5225419 CGSHiEE_02885 Haemophilus influenzae PittEE putative deoxyribonuclease YP_001290394.1 579796 R 374930 CDS YP_001290395.1 148825642 5225420 complement(580639..581148) 1 NC_009566.1 COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; peptidyl-prolyl cis-trans isomerase B 581148 5225420 CGSHiEE_02890 Haemophilus influenzae PittEE peptidyl-prolyl cis-trans isomerase B YP_001290395.1 580639 R 374930 CDS YP_001290396.1 148825643 5225421 complement(582706..583572) 1 NC_009566.1 COG2833 Uncharacterized protein conserved in bacteria; hypothetical protein 583572 5225421 CGSHiEE_02905 Haemophilus influenzae PittEE hypothetical protein YP_001290396.1 582706 R 374930 CDS YP_001290397.1 148825644 5225747 complement(583583..584443) 1 NC_009566.1 COG1946 Acyl-CoA thioesterase; cysteinyl-tRNA synthetase 584443 cysS 5225747 cysS Haemophilus influenzae PittEE cysteinyl-tRNA synthetase YP_001290397.1 583583 R 374930 CDS YP_001290398.1 148825645 5225748 complement(584561..586687) 1 NC_009566.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 586687 5225748 CGSHiEE_02915 Haemophilus influenzae PittEE anaerobic ribonucleoside triphosphate reductase YP_001290398.1 584561 R 374930 CDS YP_001290399.1 148825646 5225749 586972..587406 1 NC_009566.1 COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; nucleotidyltransferase 587406 5225749 CGSHiEE_02920 Haemophilus influenzae PittEE nucleotidyltransferase YP_001290399.1 586972 D 374930 CDS YP_001290400.1 148825647 5225750 587403..587747 1 NC_009566.1 COG1708 Predicted nucleotidyltransferases; hypothetical protein 587747 5225750 CGSHiEE_02925 Haemophilus influenzae PittEE hypothetical protein YP_001290400.1 587403 D 374930 CDS YP_001290401.1 148825648 5225751 complement(587760..588464) 1 NC_009566.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 588464 5225751 CGSHiEE_02930 Haemophilus influenzae PittEE heat shock protein GrpE YP_001290401.1 587760 R 374930 CDS YP_001290402.1 148825649 5225752 588456..589346 1 NC_009566.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 589346 ppnK 5225752 ppnK Haemophilus influenzae PittEE inorganic polyphosphate/ATP-NAD kinase YP_001290402.1 588456 D 374930 CDS YP_001290403.1 148825650 5225870 589458..591134 1 NC_009566.1 COG0497 ATPase involved in DNA repair; DNA repair protein 591134 5225870 CGSHiEE_02940 Haemophilus influenzae PittEE DNA repair protein YP_001290403.1 589458 D 374930 CDS YP_001290404.1 148825651 5225871 complement(594107..595042) 1 NC_009566.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 595042 miaA 5225871 miaA Haemophilus influenzae PittEE tRNA delta(2)-isopentenylpyrophosphate transferase YP_001290404.1 594107 R 374930 CDS YP_001290405.1 148825652 5225872 complement(595050..596939) 1 NC_009566.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 596939 mutL 5225872 mutL Haemophilus influenzae PittEE DNA mismatch repair protein YP_001290405.1 595050 R 374930 CDS YP_001290406.1 148825653 5225873 complement(597109..597996) 1 NC_009566.1 COG0860 N-acetylmuramoyl-L-alanine amidase; N-acetylmuramoyl-L-alanine amidase AmiB 597996 5225873 CGSHiEE_02965 Haemophilus influenzae PittEE N-acetylmuramoyl-L-alanine amidase AmiB YP_001290406.1 597109 R 374930 CDS YP_001290407.1 148825654 5225874 complement(598248..598685) 1 NC_009566.1 COG0802 Predicted ATPase or kinase; hypothetical protein 598685 5225874 CGSHiEE_02970 Haemophilus influenzae PittEE hypothetical protein YP_001290407.1 598248 R 374930 CDS YP_001290408.1 148825655 5225268 complement(598800..599282) 1 NC_009566.1 COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 599282 5225268 CGSHiEE_02975 Haemophilus influenzae PittEE 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_001290408.1 598800 R 374930 CDS YP_001290409.1 148825656 5225269 complement(599291..600835) 1 NC_009566.1 COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; poly polymerase 600835 5225269 CGSHiEE_02980 Haemophilus influenzae PittEE poly polymerase YP_001290409.1 599291 R 374930 CDS YP_001290410.1 148825657 5225270 complement(600898..601335) 1 NC_009566.1 DnaK suppressor protein 601335 5225270 CGSHiEE_02985 Haemophilus influenzae PittEE DnaK suppressor protein YP_001290410.1 600898 R 374930 CDS YP_001290411.1 148825658 5225271 complement(601579..601794) 1 NC_009566.1 COG1734 DnaK suppressor protein; hypothetical protein 601794 5225271 CGSHiEE_02990 Haemophilus influenzae PittEE hypothetical protein YP_001290411.1 601579 R 374930 CDS YP_001290412.1 148825659 5225272 601804..603963 1 NC_009566.1 COG0658 Predicted membrane metal-binding protein; DNA mismatch repair protein 603963 mutL 5225272 mutL Haemophilus influenzae PittEE DNA mismatch repair protein YP_001290412.1 601804 D 374930 CDS YP_001290413.1 148825660 5225273 604004..605767 1 NC_009566.1 involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease protein 605767 5225273 CGSHiEE_03000 Haemophilus influenzae PittEE lipid transporter ATP-binding/permease protein YP_001290413.1 604004 D 374930 CDS YP_001290414.1 148825661 5225013 605840..606838 1 NC_009566.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 606838 lpxK 5225013 lpxK Haemophilus influenzae PittEE tetraacyldisaccharide 4'-kinase YP_001290414.1 605840 D 374930 CDS YP_001290415.1 148825662 5225014 606909..607673 1 NC_009566.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 607673 5225014 CGSHiEE_03010 Haemophilus influenzae PittEE 3-deoxy-manno-octulosonate cytidylyltransferase YP_001290415.1 606909 D 374930 CDS YP_001290416.1 148825663 5225015 607674..607847 1 NC_009566.1 COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase; hypothetical protein 607847 5225015 CGSHiEE_03015 Haemophilus influenzae PittEE hypothetical protein YP_001290416.1 607674 D 374930 CDS YP_001290417.1 148825664 5225016 607819..609648 1 NC_009566.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 609648 uvrC 5225016 uvrC Haemophilus influenzae PittEE excinuclease ABC subunit C YP_001290417.1 607819 D 374930 CDS YP_001290418.1 148825665 5225017 609746..610459 1 NC_009566.1 COG0861 Membrane protein TerC, possibly involved in tellurium resistance; excinuclease ABC subunit C 610459 uvrC 5225017 uvrC Haemophilus influenzae PittEE excinuclease ABC subunit C YP_001290418.1 609746 D 374930 CDS YP_001290419.1 148825666 5224841 complement(610512..611696) 1 NC_009566.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 611696 5224841 CGSHiEE_03030 Haemophilus influenzae PittEE mannonate dehydratase YP_001290419.1 610512 R 374930 CDS YP_001290420.1 148825667 5224842 complement(611724..612473) 1 NC_009566.1 COG2186 Transcriptional regulators; uxu operon regulator 612473 5224842 CGSHiEE_03035 Haemophilus influenzae PittEE uxu operon regulator YP_001290420.1 611724 R 374930 CDS YP_001290421.1 148825668 5224843 612633..614675 1 NC_009566.1 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; zinc-type alcohol dehydrogenase 614675 5224843 CGSHiEE_03040 Haemophilus influenzae PittEE zinc-type alcohol dehydrogenase YP_001290421.1 612633 D 374930 CDS YP_001290422.1 148825669 5224844 614741..615175 1 NC_009566.1 COG3090 TRAP-type C4-dicarboxylate transport system, small permease component; putative TRAP-type C4-dicarboxylate transport system, small permease 615175 5224844 CGSHiEE_03045 Haemophilus influenzae PittEE putative TRAP-type C4-dicarboxylate transport system, small permease YP_001290422.1 614741 D 374930 CDS YP_001290423.1 148825670 5224845 615222..616493 1 NC_009566.1 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component; putative TRAP-type C4-dicarboxylate transport system, large permease 616493 5224845 CGSHiEE_03050 Haemophilus influenzae PittEE putative TRAP-type C4-dicarboxylate transport system, large permease YP_001290423.1 615222 D 374930 CDS YP_001290424.1 148825671 5224846 616513..617457 1 NC_009566.1 COG0524 Sugar kinases, ribokinase family; mannonate dehydratase 617457 5224846 CGSHiEE_03055 Haemophilus influenzae PittEE mannonate dehydratase YP_001290424.1 616513 D 374930 CDS YP_001290425.1 148825672 5225717 617469..618314 1 NC_009566.1 Converts D-mannonate to D-mannuronate; D-mannonate oxidoreductase 618314 5225717 CGSHiEE_03060 Haemophilus influenzae PittEE D-mannonate oxidoreductase YP_001290425.1 617469 D 374930 CDS YP_001290426.1 148825673 5225718 618330..618968 1 NC_009566.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 618968 5225718 CGSHiEE_03065 Haemophilus influenzae PittEE keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_001290426.1 618330 D 374930 CDS YP_001290427.1 148825674 5225719 complement(619021..619347) 1 NC_009566.1 COG2824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism; hypothetical protein 619347 5225719 CGSHiEE_03070 Haemophilus influenzae PittEE hypothetical protein YP_001290427.1 619021 R 374930 CDS YP_001290428.1 148825675 5225720 619450..620004 1 NC_009566.1 COG3054 Predicted transcriptional regulator; hypothetical protein 620004 5225720 CGSHiEE_03075 Haemophilus influenzae PittEE hypothetical protein YP_001290428.1 619450 D 374930 CDS YP_001290429.1 148825676 5225721 620331..620993 1 NC_009566.1 COG0670 Integral membrane protein, interacts with FtsH; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 620993 5225721 CGSHiEE_03080 Haemophilus influenzae PittEE keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_001290429.1 620331 D 374930 CDS YP_001290430.1 148825677 5225722 621052..622116 1 NC_009566.1 COG3768 Predicted membrane protein; hypothetical protein 622116 5225722 CGSHiEE_03085 Haemophilus influenzae PittEE hypothetical protein YP_001290430.1 621052 D 374930 CDS YP_001290431.1 148825678 5225926 622116..622790 1 NC_009566.1 COG0564 Pseudouridylate synthases, 23S RNA-specific; hypothetical protein 622790 5225926 CGSHiEE_03090 Haemophilus influenzae PittEE hypothetical protein YP_001290431.1 622116 D 374930 CDS YP_001290432.1 148825679 5225927 622838..623641 1 NC_009566.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 623641 5225927 CGSHiEE_03095 Haemophilus influenzae PittEE exonuclease III YP_001290432.1 622838 D 374930 CDS YP_001290433.1 148825680 5225928 623651..624427 1 NC_009566.1 COG3076 Uncharacterized protein conserved in bacteria; hypothetical protein 624427 5225928 CGSHiEE_03100 Haemophilus influenzae PittEE hypothetical protein YP_001290433.1 623651 D 374930 CDS YP_001290434.1 148825681 5225929 complement(624478..624966) 1 NC_009566.1 rod shape-determining protein MreD 624966 5225929 CGSHiEE_03105 Haemophilus influenzae PittEE rod shape-determining protein MreD YP_001290434.1 624478 R 374930 CDS YP_001290435.1 148825682 5225930 complement(626103..627134) 1 NC_009566.1 functions in MreBCD complex in some organisms; rod shape-determining protein MreB 627134 5225930 CGSHiEE_03125 Haemophilus influenzae PittEE rod shape-determining protein MreB YP_001290435.1 626103 R 374930 CDS YP_001290436.1 148825683 5226093 complement(627287..629065) 1 NC_009566.1 COG4178 ABC-type uncharacterized transport system, permease and ATPase components; exonuclease III 629065 5226093 CGSHiEE_03130 Haemophilus influenzae PittEE exonuclease III YP_001290436.1 627287 R 374930 CDS YP_001290437.1 148825684 5226094 629271..630926 1 NC_009566.1 COG2985 Predicted permease; hypothetical protein 630926 5226094 CGSHiEE_03135 Haemophilus influenzae PittEE hypothetical protein YP_001290437.1 629271 D 374930 CDS YP_001290438.1 148825685 5226095 631051..631359 1 NC_009566.1 COG0799 Uncharacterized homolog of plant Iojap protein; hypothetical protein 631359 5226095 CGSHiEE_03140 Haemophilus influenzae PittEE hypothetical protein YP_001290438.1 631051 D 374930 CDS YP_001290439.1 148825686 5226096 631413..631880 1 NC_009566.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 631880 5226096 CGSHiEE_03145 Haemophilus influenzae PittEE rRNA large subunit methyltransferase YP_001290439.1 631413 D 374930 CDS YP_001290440.1 148825687 5226097 631902..633857 1 NC_009566.1 COG0768 Cell division protein FtsI/penicillin-binding protein 2; penicillin-binding protein 2 633857 5226097 CGSHiEE_03150 Haemophilus influenzae PittEE penicillin-binding protein 2 YP_001290440.1 631902 D 374930 CDS YP_001290441.1 148825688 5225318 633847..634962 1 NC_009566.1 COG0772 Bacterial cell division membrane protein; rod shape-determining protein 634962 5225318 CGSHiEE_03155 Haemophilus influenzae PittEE rod shape-determining protein YP_001290441.1 633847 D 374930 CDS YP_001290442.1 148825689 5225319 635015..635878 1 NC_009566.1 COG0797 Lipoproteins; lipoprotein 635878 5225319 CGSHiEE_03160 Haemophilus influenzae PittEE lipoprotein YP_001290442.1 635015 D 374930 CDS YP_001290443.1 148825690 5225320 635973..637076 1 NC_009566.1 COG1686 D-alanyl-D-alanine carboxypeptidase; hypothetical protein 637076 5225320 CGSHiEE_03165 Haemophilus influenzae PittEE hypothetical protein YP_001290443.1 635973 D 374930 CDS YP_001290444.1 148825691 5225321 637132..637410 1 NC_009566.1 COG2921 Uncharacterized conserved protein; hypothetical protein 637410 5225321 CGSHiEE_03170 Haemophilus influenzae PittEE hypothetical protein YP_001290444.1 637132 D 374930 CDS YP_001290445.1 148825692 5225322 637412..638050 1 NC_009566.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 638050 lipB 5225322 lipB Haemophilus influenzae PittEE lipoate-protein ligase B YP_001290445.1 637412 D 374930 CDS YP_001290446.1 148825693 5225323 638104..639066 1 NC_009566.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 639066 5225323 CGSHiEE_03180 Haemophilus influenzae PittEE lipoyl synthase YP_001290446.1 638104 D 374930 CDS YP_001290447.1 148825694 5225291 639317..640324 1 NC_009566.1 COG3053 Citrate lyase synthetase; citrate lyase ligase 640324 5225291 CGSHiEE_03185 Haemophilus influenzae PittEE citrate lyase ligase YP_001290447.1 639317 D 374930 CDS YP_001290448.1 148825695 5225292 640362..640649 1 NC_009566.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma 640649 5225292 CGSHiEE_03190 Haemophilus influenzae PittEE citrate lyase subunit gamma YP_001290448.1 640362 D 374930 CDS YP_001290449.1 148825696 5225293 640646..641521 1 NC_009566.1 COG2301 Citrate lyase beta subunit; citrate lyase beta chain 641521 5225293 CGSHiEE_03195 Haemophilus influenzae PittEE citrate lyase beta chain YP_001290449.1 640646 D 374930 CDS YP_001290450.1 148825697 5225294 641536..643038 1 NC_009566.1 COG3051 Citrate lyase, alpha subunit; citrate lyase subunit alpha 643038 5225294 CGSHiEE_03200 Haemophilus influenzae PittEE citrate lyase subunit alpha YP_001290450.1 641536 D 374930 CDS YP_001290451.1 148825698 5225295 643219..644616 1 NC_009566.1 COG3697 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase); bifunctional Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase/ATP:dephospho-CoA triphosphoribosyl transferase 644616 5225295 CGSHiEE_03205 Haemophilus influenzae PittEE bifunctional Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase/ATP:dephospho-CoA triphosphoribosyl transferase YP_001290451.1 643219 D 374930 CDS YP_001290452.1 148825699 5225088 644618..646057 1 NC_009566.1 COG0471 Di- and tricarboxylate transporters; hypothetical protein 646057 5225088 CGSHiEE_03210 Haemophilus influenzae PittEE hypothetical protein YP_001290452.1 644618 D 374930 CDS YP_001290453.1 148825700 5225089 646440..647864 1 NC_009566.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 647864 5225089 CGSHiEE_03215 Haemophilus influenzae PittEE (dimethylallyl)adenosine tRNA methylthiotransferase YP_001290453.1 646440 D 374930 CDS YP_001290454.1 148825701 5225090 complement(647934..648593) 1 NC_009566.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 648593 5225090 CGSHiEE_03220 Haemophilus influenzae PittEE uracil-DNA glycosylase YP_001290454.1 647934 R 374930 CDS YP_001290455.1 148825702 5225091 648851..649234 1 NC_009566.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA 649234 5225091 CGSHiEE_03225 Haemophilus influenzae PittEE autonomous glycyl radical cofactor GrcA YP_001290455.1 648851 D 374930 CDS YP_001290456.1 148825703 5225092 649403..651199 1 NC_009566.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 651199 5225092 CGSHiEE_03230 Haemophilus influenzae PittEE GTP-binding protein LepA YP_001290456.1 649403 D 374930 CDS YP_001290457.1 148825704 5225093 651208..652257 1 NC_009566.1 COG0681 Signal peptidase I; GTP-binding protein LepA 652257 5225093 CGSHiEE_03235 Haemophilus influenzae PittEE GTP-binding protein LepA YP_001290457.1 651208 D 374930 CDS YP_001290458.1 148825705 5224965 652259..652942 1 NC_009566.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 652942 rnc 5224965 rnc Haemophilus influenzae PittEE ribonuclease III YP_001290458.1 652259 D 374930 CDS YP_001290459.1 148825706 5224966 complement(653912..654904) 1 NC_009566.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase 654904 rsmC 5224966 rsmC Haemophilus influenzae PittEE 16S ribosomal RNA m2G1207 methyltransferase YP_001290459.1 653912 R 374930 CDS YP_001290460.1 148825707 5224967 655010..655414 1 NC_009566.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 655414 5224967 CGSHiEE_03260 Haemophilus influenzae PittEE DNA polymerase III subunit psi YP_001290460.1 655010 D 374930 CDS YP_001290461.1 148825708 5224968 655390..655857 1 NC_009566.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 655857 rimI 5224968 rimI Haemophilus influenzae PittEE ribosomal-protein-alanine N-acetyltransferase YP_001290461.1 655390 D 374930 CDS YP_001290462.1 148825709 5224969 complement(655896..656804) 1 NC_009566.1 required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 656804 5224969 CGSHiEE_03270 Haemophilus influenzae PittEE formate dehydrogenase accessory protein FdhE YP_001290462.1 655896 R 374930 CDS YP_001290463.1 148825710 5224954 complement(656874..657590) 1 NC_009566.1 COG2864 Cytochrome b subunit of formate dehydrogenase; formate dehydrogenase subunit gamma 657590 5224954 CGSHiEE_03275 Haemophilus influenzae PittEE formate dehydrogenase subunit gamma YP_001290463.1 656874 R 374930 CDS YP_001290464.1 148825711 5224955 complement(657583..658521) 1 NC_009566.1 COG0437 Fe-S-cluster-containing hydrogenase components 1; formate dehydrogenase iron-sulfur subunit 658521 5224955 CGSHiEE_03280 Haemophilus influenzae PittEE formate dehydrogenase iron-sulfur subunit YP_001290464.1 657583 R 374930 CDS YP_001290465.1 148825712 5224956 complement(658523..660949) 1 NC_009566.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; formate dehydrogenase major subunit 660949 5224956 CGSHiEE_03285 Haemophilus influenzae PittEE formate dehydrogenase major subunit YP_001290465.1 658523 R 374930 CDS YP_001290466.1 148825713 5224957 complement(660998..661609) 1 NC_009566.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; formate dehydrogenase accessory protein FdhE 661609 5224957 CGSHiEE_03290 Haemophilus influenzae PittEE formate dehydrogenase accessory protein FdhE YP_001290466.1 660998 R 374930 CDS YP_001290467.1 148825714 5224958 662030..662692 1 NC_009566.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 662692 5224958 CGSHiEE_03295 Haemophilus influenzae PittEE formate dehydrogenase accessory protein YP_001290467.1 662030 D 374930 CDS YP_001290468.1 148825715 5224959 662950..663414 1 NC_009566.1 COG0319 Predicted metal-dependent hydrolase; putative metalloprotease 663414 5224959 CGSHiEE_03300 Haemophilus influenzae PittEE putative metalloprotease YP_001290468.1 662950 D 374930 CDS YP_001290469.1 148825716 5225753 663433..664218 1 NC_009566.1 COG0561 Predicted hydrolases of the HAD superfamily; haloacid dehalogenase-like protein 664218 5225753 CGSHiEE_03305 Haemophilus influenzae PittEE haloacid dehalogenase-like protein YP_001290469.1 663433 D 374930 CDS YP_001290470.1 148825717 5225754 complement(664255..666054) 1 NC_009566.1 COG1022 Long-chain acyl-CoA synthetases (AMP-forming); long chain fatty acid CoA ligase 666054 5225754 CGSHiEE_03310 Haemophilus influenzae PittEE long chain fatty acid CoA ligase YP_001290470.1 664255 R 374930 CDS YP_001290471.1 148825718 5225755 complement(666249..667268) 1 NC_009566.1 COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase 667268 5225755 CGSHiEE_03315 Haemophilus influenzae PittEE glyceraldehyde-3-phosphate dehydrogenase YP_001290471.1 666249 R 374930 CDS YP_001290472.1 148825719 5225756 667520..668146 1 NC_009566.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 668146 gmk 5225756 gmk Haemophilus influenzae PittEE guanylate kinase YP_001290472.1 667520 D 374930 CDS YP_001290473.1 148825720 5225757 668209..668475 1 NC_009566.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 668475 rpoZ 5225757 rpoZ Haemophilus influenzae PittEE DNA-directed RNA polymerase subunit omega YP_001290473.1 668209 D 374930 CDS YP_001290474.1 148825721 5225758 668548..670662 1 NC_009566.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; guanosine-3',5'-bis 3'-pyrophosphohydrolase 670662 5225758 CGSHiEE_03330 Haemophilus influenzae PittEE guanosine-3',5'-bis 3'-pyrophosphohydrolase YP_001290474.1 668548 D 374930 CDS YP_001290475.1 148825722 5225156 670659..672740 1 NC_009566.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 672740 rpoZ 5225156 rpoZ Haemophilus influenzae PittEE ATP-dependent DNA helicase RecG YP_001290475.1 670659 D 374930 CDS YP_001290476.1 148825723 5225157 672770..673579 1 NC_009566.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 673579 5225157 CGSHiEE_03340 Haemophilus influenzae PittEE glutamate racemase YP_001290476.1 672770 D 374930 CDS YP_001290477.1 148825724 5225158 673793..674938 1 NC_009566.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 674938 lldD 5225158 lldD Haemophilus influenzae PittEE L-lactate dehydrogenase YP_001290477.1 673793 D 374930 CDS YP_001290478.1 148825725 5225509 681272..682201 1 NC_009566.1 COG0583 Transcriptional regulator; transcriptional activator 682201 5225509 CGSHiEE_03350 Haemophilus influenzae PittEE transcriptional activator YP_001290478.1 681272 D 374930 CDS YP_001290479.1 148825726 5225510 682211..682945 1 NC_009566.1 COG1296 Predicted branched-chain amino acid permease (azaleucine resistance); putative branched-chain amino acid permease 682945 5225510 CGSHiEE_03355 Haemophilus influenzae PittEE putative branched-chain amino acid permease YP_001290479.1 682211 D 374930 CDS YP_001290480.1 148825727 5225511 682942..683271 1 NC_009566.1 putative branched-chain amino acid permease 683271 5225511 CGSHiEE_03360 Haemophilus influenzae PittEE putative branched-chain amino acid permease YP_001290480.1 682942 D 374930 CDS YP_001290481.1 148825728 5225512 683374..683607 1 NC_009566.1 COG1687 Predicted branched-chain amino acid permeases (azaleucine resistance); L-lactate dehydrogenase 683607 lldD 5225512 lldD Haemophilus influenzae PittEE L-lactate dehydrogenase YP_001290481.1 683374 D 374930 CDS YP_001290482.1 148825729 5225620 complement(683683..685266) 1 NC_009566.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 685266 prfC 5225620 prfC Haemophilus influenzae PittEE peptide chain release factor 3 YP_001290482.1 683683 R 374930 CDS YP_001290483.1 148825730 5225621 685445..686233 1 NC_009566.1 COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH); peptide chain release factor 3 686233 prfC 5225621 prfC Haemophilus influenzae PittEE peptide chain release factor 3 YP_001290483.1 685445 D 374930 CDS YP_001290484.1 148825731 5225624 688573..689214 1 NC_009566.1 COG2049 Allophanate hydrolase subunit 1; allophanate hydrolase subunit 1 689214 5225624 CGSHiEE_03390 Haemophilus influenzae PittEE allophanate hydrolase subunit 1 YP_001290484.1 688573 D 374930 CDS YP_001290485.1 148825732 5226160 689211..690140 1 NC_009566.1 COG1984 Allophanate hydrolase subunit 2; exoribonuclease II 690140 5226160 CGSHiEE_03395 Haemophilus influenzae PittEE exoribonuclease II YP_001290485.1 689211 D 374930 CDS YP_001290486.1 148825733 5226161 690127..690864 1 NC_009566.1 COG1540 Uncharacterized proteins, homologs of lactam utilization protein B; LamB/YcsF family protein 690864 5226161 CGSHiEE_03400 Haemophilus influenzae PittEE LamB/YcsF family protein YP_001290486.1 690127 D 374930 CDS YP_001290487.1 148825734 5226162 complement(692179..693513) 1 NC_009566.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 693513 5226162 CGSHiEE_03415 Haemophilus influenzae PittEE argininosuccinate synthase YP_001290487.1 692179 R 374930 CDS YP_001290488.1 148825735 5225236 complement(693669..694541) 1 NC_009566.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 694541 5225236 CGSHiEE_03420 Haemophilus influenzae PittEE phosphoribosylaminoimidazole-succinocarboxamide synthase YP_001290488.1 693669 R 374930 CDS YP_001290489.1 148825736 5225237 complement(694707..697055) 1 NC_009566.1 COG0744 Membrane carboxypeptidase (penicillin-binding protein); phosphoribosylaminoimidazole-succinocarboxamide synthase 697055 5225237 CGSHiEE_03425 Haemophilus influenzae PittEE phosphoribosylaminoimidazole-succinocarboxamide synthase YP_001290489.1 694707 R 374930 CDS YP_001290490.1 148825737 5225238 complement(697062..697205) 1 NC_009566.1 COG3112 Uncharacterized protein conserved in bacteria; hypothetical protein 697205 5225238 CGSHiEE_03430 Haemophilus influenzae PittEE hypothetical protein YP_001290490.1 697062 R 374930 CDS YP_001290491.1 148825738 5225239 complement(697418..697762) 1 NC_009566.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 697762 5225239 CGSHiEE_03435 Haemophilus influenzae PittEE iron-sulfur cluster insertion protein ErpA YP_001290491.1 697418 R 374930 CDS YP_001290492.1 148825739 5225240 697899..698705 1 NC_009566.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 698705 5225240 CGSHiEE_03440 Haemophilus influenzae PittEE methionine aminopeptidase YP_001290492.1 697899 D 374930 CDS YP_001290493.1 148825740 5225241 698798..701389 1 NC_009566.1 COG2844 UTP:GlnB (protein PII) uridylyltransferase; PII uridylyl-transferase 701389 glnD 5225241 glnD Haemophilus influenzae PittEE PII uridylyl-transferase YP_001290493.1 698798 D 374930 CDS YP_001290494.1 148825741 5224889 701464..702531 1 NC_009566.1 COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase; PII uridylyl-transferase 702531 glnD 5224889 glnD Haemophilus influenzae PittEE PII uridylyl-transferase YP_001290494.1 701464 D 374930 CDS YP_001290495.1 148825742 5224890 complement(702931..703479) 1 NC_009566.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 703479 5224890 CGSHiEE_03455 Haemophilus influenzae PittEE oligoribonuclease YP_001290495.1 702931 R 374930 CDS YP_001290496.1 148825743 5224891 703550..704590 1 NC_009566.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 704590 5224891 CGSHiEE_03460 Haemophilus influenzae PittEE ribosome-associated GTPase YP_001290496.1 703550 D 374930 CDS YP_001290497.1 148825744 5224892 704749..705006 1 NC_009566.1 COG1925 Phosphotransferase system, HPr-related proteins; ribosome-associated GTPase 705006 5224892 CGSHiEE_03465 Haemophilus influenzae PittEE ribosome-associated GTPase YP_001290497.1 704749 D 374930 CDS YP_001290498.1 148825745 5224893 705086..706813 1 NC_009566.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 706813 5224893 CGSHiEE_03470 Haemophilus influenzae PittEE phosphoenolpyruvate-protein phosphotransferase YP_001290498.1 705086 D 374930 CDS YP_001290499.1 148825746 5224894 706873..707373 1 NC_009566.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter subunit 707373 5224894 CGSHiEE_03475 Haemophilus influenzae PittEE PTS system glucose-specific transporter subunit YP_001290499.1 706873 D 374930 CDS YP_001290500.1 148825747 5224835 707556..707768 1 NC_009566.1 COG3257 Uncharacterized protein, possibly involved in glyoxylate utilization; hypothetical protein 707768 5224835 CGSHiEE_03480 Haemophilus influenzae PittEE hypothetical protein YP_001290500.1 707556 D 374930 CDS YP_001290501.1 148825748 5224836 707883..708248 1 NC_009566.1 COG3111 Uncharacterized conserved protein; hypothetical protein 708248 5224836 CGSHiEE_03485 Haemophilus influenzae PittEE hypothetical protein YP_001290501.1 707883 D 374930 CDS YP_001290502.1 148825749 5224837 708313..708978 1 NC_009566.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; transcriptional regulatory protein 708978 5224837 CGSHiEE_03490 Haemophilus influenzae PittEE transcriptional regulatory protein YP_001290502.1 708313 D 374930 CDS YP_001290503.1 148825750 5224838 708975..710330 1 NC_009566.1 COG0642 Signal transduction histidine kinase; sensor protein QseC 710330 5224838 CGSHiEE_03495 Haemophilus influenzae PittEE sensor protein QseC YP_001290503.1 708975 D 374930 CDS YP_001290504.1 148825751 5224839 710607..712634 1 NC_009566.1 COG1292 Choline-glycine betaine transporter; glucose-specific PTS system enzyme IIA component 712634 5224839 CGSHiEE_03500 Haemophilus influenzae PittEE glucose-specific PTS system enzyme IIA component YP_001290504.1 710607 D 374930 CDS YP_001290505.1 148825752 5224840 complement(712670..714145) 1 NC_009566.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 714145 5224840 CGSHiEE_03505 Haemophilus influenzae PittEE leucyl aminopeptidase YP_001290505.1 712670 R 374930 CDS YP_001290506.1 148825753 5225772 714253..715356 1 NC_009566.1 COG0795 Predicted permeases; permease 715356 5225772 CGSHiEE_03510 Haemophilus influenzae PittEE permease YP_001290506.1 714253 D 374930 CDS YP_001290507.1 148825754 5225773 715353..716429 1 NC_009566.1 COG0795 Predicted permeases; leucyl aminopeptidase 716429 5225773 CGSHiEE_03515 Haemophilus influenzae PittEE leucyl aminopeptidase YP_001290507.1 715353 D 374930 CDS YP_001290508.1 148825755 5225774 716623..718893 1 NC_009566.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 718893 5225774 CGSHiEE_03520 Haemophilus influenzae PittEE 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase YP_001290508.1 716623 D 374930 CDS YP_001290509.1 148825756 5225775 complement(719116..719859) 1 NC_009566.1 COG1434 Uncharacterized conserved protein; hypothetical protein 719859 5225775 CGSHiEE_03525 Haemophilus influenzae PittEE hypothetical protein YP_001290509.1 719116 R 374930 CDS YP_001290510.1 148825757 5225776 719994..721199 1 NC_009566.1 putative lipooligosaccharide flippase 721199 5225776 CGSHiEE_03530 Haemophilus influenzae PittEE putative lipooligosaccharide flippase YP_001290510.1 719994 D 374930 CDS YP_001290511.1 148825758 5225150 722113..723174 1 NC_009566.1 COG0438 Glycosyltransferase; putative UDP-galactose--lipooligosaccharide galactosyltransferase 723174 5225150 CGSHiEE_03545 Haemophilus influenzae PittEE putative UDP-galactose--lipooligosaccharide galactosyltransferase YP_001290511.1 722113 D 374930 CDS YP_001290512.1 148825759 5225151 723186..723959 1 NC_009566.1 COG3306 Glycosyltransferase involved in LPS biosynthesis; putative UDP-GlcNAc--lipooligosaccharide N-acetylglucosaminyl glycosyltransferase 723959 5225151 CGSHiEE_03550 Haemophilus influenzae PittEE putative UDP-GlcNAc--lipooligosaccharide N-acetylglucosaminyl glycosyltransferase YP_001290512.1 723186 D 374930 CDS YP_001290513.1 148825760 5225152 723971..724855 1 NC_009566.1 COG0463 Glycosyltransferases involved in cell wall biogenesis; putative UDP-galactose--lipooligosaccharide galactosyltransferase 724855 5225152 CGSHiEE_03555 Haemophilus influenzae PittEE putative UDP-galactose--lipooligosaccharide galactosyltransferase YP_001290513.1 723971 D 374930 CDS YP_001290514.1 148825761 5225153 724857..725660 1 NC_009566.1 COG0463 Glycosyltransferases involved in cell wall biogenesis; putative UDP-galactose--lipooligosaccharide galactosyltransferase 725660 5225153 CGSHiEE_03560 Haemophilus influenzae PittEE putative UDP-galactose--lipooligosaccharide galactosyltransferase YP_001290514.1 724857 D 374930 CDS YP_001290515.1 148825762 5225154 complement(725770..726537) 1 NC_009566.1 COG2005 N-terminal domain of molybdenum-binding protein; transcriptional regulator ModE 726537 5225154 CGSHiEE_03565 Haemophilus influenzae PittEE transcriptional regulator ModE YP_001290515.1 725770 R 374930 CDS YP_001290516.1 148825763 5224914 726675..727439 1 NC_009566.1 COG0725 ABC-type molybdate transport system, periplasmic component; 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 727439 5224914 CGSHiEE_03570 Haemophilus influenzae PittEE 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase YP_001290516.1 726675 D 374930 CDS YP_001290517.1 148825764 5224915 727574..728302 1 NC_009566.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease protein 728302 modB 5224915 modB Haemophilus influenzae PittEE molybdate ABC transporter permease protein YP_001290517.1 727574 D 374930 CDS YP_001290518.1 148825765 5224916 728289..729344 1 NC_009566.1 Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 729344 modC 5224916 modC Haemophilus influenzae PittEE molybdate transporter ATP-binding protein YP_001290518.1 728289 D 374930 CDS YP_001290519.1 148825766 5224917 complement(729368..730741) 1 NC_009566.1 COG0733 Na+-dependent transporters of the SNF family; Na+-dependent transporter 730741 5224917 CGSHiEE_03585 Haemophilus influenzae PittEE Na+-dependent transporter YP_001290519.1 729368 R 374930 CDS YP_001290520.1 148825767 5224918 complement(730800..731435) 1 NC_009566.1 COG0177 Predicted EndoIII-related endonuclease; endonuclease III 731435 modC 5224918 modC Haemophilus influenzae PittEE endonuclease III YP_001290520.1 730800 R 374930 CDS YP_001290521.1 148825768 5224919 complement(731620..732327) 1 NC_009566.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex RsxE subunit 732327 5224919 CGSHiEE_03595 Haemophilus influenzae PittEE electron transport complex RsxE subunit YP_001290521.1 731620 R 374930 CDS YP_001290522.1 148825769 5225380 complement(732329..732952) 1 NC_009566.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 732952 5225380 CGSHiEE_03600 Haemophilus influenzae PittEE electron transport complex protein RnfG YP_001290522.1 732329 R 374930 CDS YP_001290523.1 148825770 5225381 complement(732952..734028) 1 NC_009566.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 734028 rnfD 5225381 rnfD Haemophilus influenzae PittEE electron transport complex protein RnfD YP_001290523.1 732952 R 374930 CDS YP_001290524.1 148825771 5225382 complement(734033..735988) 1 NC_009566.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 735988 5225382 CGSHiEE_03610 Haemophilus influenzae PittEE electron transport complex protein RnfC YP_001290524.1 734033 R 374930 CDS YP_001290525.1 148825772 5225383 complement(735989..736570) 1 NC_009566.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 736570 5225383 CGSHiEE_03615 Haemophilus influenzae PittEE electron transport complex protein RnfB YP_001290525.1 735989 R 374930 CDS YP_001290526.1 148825773 5225384 complement(736658..737236) 1 NC_009566.1 COG4657 Predicted NADH:ubiquinone oxidoreductase, subunit RnfA; Na(+)-translocating NADH-quinone reductase subunit E 737236 5225384 CGSHiEE_03620 Haemophilus influenzae PittEE Na(+)-translocating NADH-quinone reductase subunit E YP_001290526.1 736658 R 374930 CDS YP_001290527.1 148825774 5225385 complement(737520..738581) 1 NC_009566.1 SohB; periplasmic protein; member of the peptidase S49 family; putative periplasmic protease 738581 5225385 CGSHiEE_03625 Haemophilus influenzae PittEE putative periplasmic protease YP_001290527.1 737520 R 374930 CDS YP_001290528.1 148825775 5225894 738779..739444 1 NC_009566.1 COG3110 Uncharacterized protein conserved in bacteria; hypothetical protein 739444 5225894 CGSHiEE_03630 Haemophilus influenzae PittEE hypothetical protein YP_001290528.1 738779 D 374930 CDS YP_001290529.1 148825776 5225895 739512..741668 1 NC_009566.1 COG1289 Predicted membrane protein; hypothetical protein 741668 5225895 CGSHiEE_03635 Haemophilus influenzae PittEE hypothetical protein YP_001290529.1 739512 D 374930 CDS YP_001290530.1 148825777 5225896 complement(741872..743698) 1 NC_009566.1 COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family; HMW1C, putative glycosyltransferase involved in glycosylation of HMW1A and HMW2A 743698 5225896 CGSHiEE_03640 Haemophilus influenzae PittEE HMW1C, putative glycosyltransferase involved in glycosylation of HMW1A and HMW2A YP_001290530.1 741872 R 374930 CDS YP_001290531.1 148825778 5225897 complement(743913..745550) 1 NC_009566.1 COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component; HMW1B, OMP-85-like protein required for secretion of HMW1A and HMW2A 745550 5225897 CGSHiEE_03645 Haemophilus influenzae PittEE HMW1B, OMP-85-like protein required for secretion of HMW1A and HMW2A YP_001290531.1 743913 R 374930 CDS YP_001290532.1 148825779 5225898 complement(745702..750447) 1 NC_009566.1 HMW1A, high molecular weight adhesin 1 750447 5225898 CGSHiEE_03650 Haemophilus influenzae PittEE HMW1A, high molecular weight adhesin 1 YP_001290532.1 745702 R 374930 CDS YP_001290533.1 148825780 5225899 750799..750876 1 NC_009566.1 COG3210 Large exoproteins involved in heme utilization or adhesion; hypothetical protein 750876 5225899 CGSHiEE_03655 Haemophilus influenzae PittEE hypothetical protein YP_001290533.1 750799 D 374930 CDS YP_001290534.1 148825781 5225176 750967..751290 1 NC_009566.1 COG0675 Transposase and inactivated derivatives; transposase 751290 5225176 CGSHiEE_03660 Haemophilus influenzae PittEE transposase YP_001290534.1 750967 D 374930 CDS YP_001290535.1 148825782 5225177 complement(751534..752076) 1 NC_009566.1 COG1778 Low specificity phosphatase (HAD superfamily); 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 752076 5225177 CGSHiEE_03665 Haemophilus influenzae PittEE 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase YP_001290535.1 751534 R 374930 CDS YP_001290536.1 148825783 5225178 complement(752086..753021) 1 NC_009566.1 COG0794 Predicted sugar phosphate isomerase involved in capsule formation; arabinose-5-phosphate isomerase 753021 5225178 CGSHiEE_03670 Haemophilus influenzae PittEE arabinose-5-phosphate isomerase YP_001290536.1 752086 R 374930 CDS YP_001290537.1 148825784 5225179 complement(753635..754306) 1 NC_009566.1 Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein 754306 5225179 CGSHiEE_03675 Haemophilus influenzae PittEE iron-sulfur cluster repair di-iron protein YP_001290537.1 753635 R 374930 CDS YP_001290538.1 148825785 5225180 754751..755764 1 NC_009566.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 755764 moaA 5225180 moaA Haemophilus influenzae PittEE molybdenum cofactor biosynthesis protein A YP_001290538.1 754751 D 374930 CDS YP_001290539.1 148825786 5225181 755855..756337 1 NC_009566.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 756337 moaC 5225181 moaC Haemophilus influenzae PittEE molybdenum cofactor biosynthesis protein MoaC YP_001290539.1 755855 D 374930 CDS YP_001290540.1 148825787 5224938 756339..756584 1 NC_009566.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 756584 moaD 5224938 moaD Haemophilus influenzae PittEE molybdopterin synthase small subunit YP_001290540.1 756339 D 374930 CDS YP_001290541.1 148825788 5224939 756585..757037 1 NC_009566.1 COG0314 Molybdopterin converting factor, large subunit; molybdopterin converting factor subunit 2 757037 5224939 CGSHiEE_03695 Haemophilus influenzae PittEE molybdopterin converting factor subunit 2 YP_001290541.1 756585 D 374930 CDS YP_001290542.1 148825789 5224940 complement(757092..759737) 1 NC_009566.1 COG3008 Paraquat-inducible protein B; paraquat-inducible protein B-like protein 759737 5224940 CGSHiEE_03700 Haemophilus influenzae PittEE paraquat-inducible protein B-like protein YP_001290542.1 757092 R 374930 CDS YP_001290543.1 148825790 5224941 complement(759721..760971) 1 NC_009566.1 COG2995 Uncharacterized paraquat-inducible protein A; molybdopterin synthase small subunit 760971 moaD 5224941 moaD Haemophilus influenzae PittEE molybdopterin synthase small subunit YP_001290543.1 759721 R 374930 CDS YP_001290544.1 148825791 5224942 761156..761794 1 NC_009566.1 affects solute and DNA transport through an unknown mechanism; putative solute/DNA competence effector 761794 5224942 CGSHiEE_03710 Haemophilus influenzae PittEE putative solute/DNA competence effector YP_001290544.1 761156 D 374930 CDS YP_001290545.1 148825792 5224943 761822..763903 1 NC_009566.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 763903 5224943 CGSHiEE_03715 Haemophilus influenzae PittEE carboxy-terminal protease YP_001290545.1 761822 D 374930 CDS YP_001290546.1 148825793 5225374 763977..765446 1 NC_009566.1 COG2989 Uncharacterized protein conserved in bacteria; hypothetical protein 765446 5225374 CGSHiEE_03720 Haemophilus influenzae PittEE hypothetical protein YP_001290546.1 763977 D 374930 CDS YP_001290547.1 148825794 5225375 765462..766022 1 NC_009566.1 COG3108 Uncharacterized protein conserved in bacteria; hypothetical protein 766022 5225375 CGSHiEE_03725 Haemophilus influenzae PittEE hypothetical protein YP_001290547.1 765462 D 374930 CDS YP_001290548.1 148825795 5225376 766158..766829 1 NC_009566.1 COG0084 Mg-dependent DNase; putative deoxyribonuclease 766829 5225376 CGSHiEE_03730 Haemophilus influenzae PittEE putative deoxyribonuclease YP_001290548.1 766158 D 374930 CDS YP_001290549.1 148825796 5225377 766839..767477 1 NC_009566.1 COG0491 Zn-dependent hydrolases, including glyoxylases; carboxy-terminal protease 767477 5225377 CGSHiEE_03735 Haemophilus influenzae PittEE carboxy-terminal protease YP_001290549.1 766839 D 374930 CDS YP_001290550.1 148825797 5225378 767680..770487 1 NC_009566.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 770487 sucA 5225378 sucA Haemophilus influenzae PittEE 2-oxoglutarate dehydrogenase E1 component YP_001290550.1 767680 D 374930 CDS YP_001290551.1 148825798 5225379 770594..771823 1 NC_009566.1 COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes; alpha-ketoglutarate decarboxylase 771823 kgd 5225379 kgd Haemophilus influenzae PittEE alpha-ketoglutarate decarboxylase YP_001290551.1 770594 D 374930 CDS YP_001290552.1 148825799 5225513 complement(771946..773076) 1 NC_009566.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 773076 nrdB 5225513 nrdB Haemophilus influenzae PittEE ribonucleotide-diphosphate reductase subunit beta YP_001290552.1 771946 R 374930 CDS YP_001290553.1 148825800 5225514 complement(773201..773485) 1 NC_009566.1 COG0208 Ribonucleotide reductase, beta subunit; hypothetical protein 773485 5225514 CGSHiEE_03755 Haemophilus influenzae PittEE hypothetical protein YP_001290553.1 773201 R 374930 CDS YP_001290554.1 148825801 5225515 complement(773499..775769) 1 NC_009566.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 775769 5225515 CGSHiEE_03760 Haemophilus influenzae PittEE ribonucleotide-diphosphate reductase subunit alpha YP_001290554.1 773499 R 374930 CDS YP_001290555.1 148825802 5225516 complement(776024..776605) 1 NC_009566.1 COG2823 Predicted periplasmic or secreted lipoprotein; hypothetical protein 776605 5225516 CGSHiEE_03765 Haemophilus influenzae PittEE hypothetical protein YP_001290555.1 776024 R 374930 CDS YP_001290556.1 148825803 5225517 complement(776662..777246) 1 NC_009566.1 COG0279 Phosphoheptose isomerase; hypothetical protein 777246 5225517 CGSHiEE_03770 Haemophilus influenzae PittEE hypothetical protein YP_001290556.1 776662 R 374930 CDS YP_001290557.1 148825804 5225518 complement(777259..777618) 1 NC_009566.1 COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase; hypothetical protein 777618 5225518 CGSHiEE_03775 Haemophilus influenzae PittEE hypothetical protein YP_001290557.1 777259 R 374930 CDS YP_001290558.1 148825805 5225125 complement(777618..779345) 1 NC_009566.1 COG3107 Putative lipoprotein; putative lipoprotein 779345 5225125 CGSHiEE_03780 Haemophilus influenzae PittEE putative lipoprotein YP_001290558.1 777618 R 374930 CDS YP_001290559.1 148825806 5225126 779417..780268 1 NC_009566.1 COG0313 Predicted methyltransferases; hypothetical protein 780268 5225126 CGSHiEE_03785 Haemophilus influenzae PittEE hypothetical protein YP_001290559.1 779417 D 374930 CDS YP_001290560.1 148825807 5225127 780370..781818 1 NC_009566.1 COG0312 Predicted Zn-dependent proteases and their inactivated homologs; hypothetical protein 781818 5225127 CGSHiEE_03790 Haemophilus influenzae PittEE hypothetical protein YP_001290560.1 780370 D 374930 CDS YP_001290561.1 148825808 5225128 781931..782482 1 NC_009566.1 COG0791 Cell wall-associated hydrolases (invasion-associated proteins); lipoprotein NlpC 782482 5225128 CGSHiEE_03795 Haemophilus influenzae PittEE lipoprotein NlpC YP_001290561.1 781931 D 374930 CDS YP_001290562.1 148825809 5225129 complement(782607..782831) 1 NC_009566.1 COG2801 Transposase and inactivated derivatives; transposase 782831 5225129 CGSHiEE_03800 Haemophilus influenzae PittEE transposase YP_001290562.1 782607 R 374930 CDS YP_001290563.1 148825810 5225130 783032..783310 1 NC_009566.1 COG0513 Superfamily II DNA and RNA helicases; hypothetical protein 783310 5225130 CGSHiEE_03805 Haemophilus influenzae PittEE hypothetical protein YP_001290563.1 783032 D 374930 CDS YP_001290564.1 148825811 5225593 783559..785253 1 NC_009566.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 785253 5225593 CGSHiEE_03810 Haemophilus influenzae PittEE D-lactate dehydrogenase YP_001290564.1 783559 D 374930 CDS YP_001290565.1 148825812 5225594 complement(785802..786380) 1 NC_009566.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 786380 5225594 CGSHiEE_03815 Haemophilus influenzae PittEE glutamine amidotransferase subunit PdxT YP_001290565.1 785802 R 374930 CDS YP_001290566.1 148825813 5225595 complement(786381..787256) 1 NC_009566.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 787256 5225595 CGSHiEE_03820 Haemophilus influenzae PittEE pyridoxal biosynthesis lyase PdxS YP_001290566.1 786381 R 374930 CDS YP_001290567.1 148825814 5225596 787725..788396 1 NC_009566.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 788396 cmk 5225596 cmk Haemophilus influenzae PittEE cytidylate kinase YP_001290567.1 787725 D 374930 CDS YP_001290568.1 148825815 5225597 790272..790556 1 NC_009566.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 790556 ihfB 5225597 ihfB Haemophilus influenzae PittEE integration host factor subunit beta YP_001290568.1 790272 D 374930 CDS YP_001290569.1 148825816 5225039 790631..790855 1 NC_009566.1 COG3771 Predicted membrane protein; 30S ribosomal protein S1 790855 rpsA 5225039 rpsA Haemophilus influenzae PittEE 30S ribosomal protein S1 YP_001290569.1 790631 D 374930 CDS YP_001290570.1 148825817 5225040 790923..792113 1 NC_009566.1 COG2956 Predicted N-acetylglucosaminyl transferase; hypothetical protein 792113 5225040 CGSHiEE_03850 Haemophilus influenzae PittEE hypothetical protein YP_001290570.1 790923 D 374930 CDS YP_001290571.1 148825818 5225041 792137..792829 1 NC_009566.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 792829 5225041 CGSHiEE_03855 Haemophilus influenzae PittEE orotidine 5'-phosphate decarboxylase YP_001290571.1 792137 D 374930 CDS YP_001290572.1 148825819 5225042 792836..793156 1 NC_009566.1 involved in start site selection during the initiation of translation; translation initiation factor Sui1 793156 5225042 CGSHiEE_03860 Haemophilus influenzae PittEE translation initiation factor Sui1 YP_001290572.1 792836 D 374930 CDS YP_001290573.1 148825820 5225043 complement(793185..793880) 1 NC_009566.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor 793880 5225043 CGSHiEE_03865 Haemophilus influenzae PittEE DNA replication initiation factor YP_001290573.1 793185 R 374930 CDS YP_001290574.1 148825821 5225044 complement(793946..795190) 1 NC_009566.1 COG2233 Xanthine/uracil permeases; DNA replication initiation factor 795190 5225044 CGSHiEE_03870 Haemophilus influenzae PittEE DNA replication initiation factor YP_001290574.1 793946 R 374930 CDS YP_001290575.1 148825822 5224758 complement(795296..795922) 1 NC_009566.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 795922 upp 5224758 upp Haemophilus influenzae PittEE uracil phosphoribosyltransferase YP_001290575.1 795296 R 374930 CDS YP_001290576.1 148825823 5224759 complement(796046..798112) 1 NC_009566.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 798112 5224759 CGSHiEE_03880 Haemophilus influenzae PittEE DNA polymerase III subunits gamma and tau YP_001290576.1 796046 R 374930 CDS YP_001290577.1 148825824 5224760 complement(798124..798666) 1 NC_009566.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 798666 5224760 CGSHiEE_03885 Haemophilus influenzae PittEE adenine phosphoribosyltransferase YP_001290577.1 798124 R 374930 CDS YP_001290578.1 148825825 5224761 798672..798779 1 NC_009566.1 COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins; adenine phosphoribosyltransferase 798779 5224761 CGSHiEE_03890 Haemophilus influenzae PittEE adenine phosphoribosyltransferase YP_001290578.1 798672 D 374930 CDS YP_001290579.1 148825826 5224762 complement(798826..800250) 1 NC_009566.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 800250 5224762 CGSHiEE_03895 Haemophilus influenzae PittEE dihydrolipoamide dehydrogenase YP_001290579.1 798826 R 374930 CDS YP_001290580.1 148825827 5224763 complement(800364..801992) 1 NC_009566.1 COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes; dihydrolipoamide acetyltransferase 801992 5224763 CGSHiEE_03900 Haemophilus influenzae PittEE dihydrolipoamide acetyltransferase YP_001290580.1 800364 R 374930 CDS YP_001290581.1 148825828 5224732 complement(802055..804715) 1 NC_009566.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 804715 aceE 5224732 aceE Haemophilus influenzae PittEE pyruvate dehydrogenase subunit E1 YP_001290581.1 802055 R 374930 CDS YP_001290582.1 148825829 5224733 805015..805473 1 NC_009566.1 catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 805473 mgsA 5224733 mgsA Haemophilus influenzae PittEE methylglyoxal synthase YP_001290582.1 805015 D 374930 CDS YP_001290583.1 148825830 5224734 complement(805630..807072) 1 NC_009566.1 hypothetical protein 807072 5224734 CGSHiEE_03915 Haemophilus influenzae PittEE hypothetical protein YP_001290583.1 805630 R 374930 CDS YP_001290584.1 148825831 5224735 complement(807073..807171) 1 NC_009566.1 COG5339 Uncharacterized protein conserved in bacteria; hypothetical protein 807171 5224735 CGSHiEE_03920 Haemophilus influenzae PittEE hypothetical protein YP_001290584.1 807073 R 374930 CDS YP_001290585.1 148825832 5224736 807325..809232 1 NC_009566.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 809232 dnaK 5224736 dnaK Haemophilus influenzae PittEE molecular chaperone DnaK YP_001290585.1 807325 D 374930 CDS YP_001290586.1 148825833 5224737 complement(810547..811800) 1 NC_009566.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 811800 proA 5224737 proA Haemophilus influenzae PittEE gamma-glutamyl phosphate reductase YP_001290586.1 810547 R 374930 CDS YP_001290587.1 148825834 5225348 complement(811821..812483) 1 NC_009566.1 hypothetical protein 812483 5225348 CGSHiEE_03945 Haemophilus influenzae PittEE hypothetical protein YP_001290587.1 811821 R 374930 CDS YP_001290588.1 148825835 5225349 812550..813380 1 NC_009566.1 COG2860 Predicted membrane protein; hypothetical protein 813380 proA 5225349 proA Haemophilus influenzae PittEE hypothetical protein YP_001290588.1 812550 D 374930 CDS YP_001290589.1 148825836 5225350 complement(813412..814434) 1 NC_009566.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system 814434 5225350 CGSHiEE_03955 Haemophilus influenzae PittEE bicyclomycin/multidrug efflux system YP_001290589.1 813412 R 374930 CDS YP_001290590.1 148825837 5225351 complement(814403..814609) 1 NC_009566.1 COG0477 Permeases of the major facilitator superfamily; bicyclomycin resistance protein 814609 5225351 CGSHiEE_03960 Haemophilus influenzae PittEE bicyclomycin resistance protein YP_001290590.1 814403 R 374930 CDS YP_001290591.1 148825838 5225352 complement(814611..815309) 1 NC_009566.1 COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; 16S pseudouridylate 516 synthase 815309 5225352 CGSHiEE_03965 Haemophilus influenzae PittEE 16S pseudouridylate 516 synthase YP_001290591.1 814611 R 374930 CDS YP_001290592.1 148825839 5225218 complement(815400..815990) 1 NC_009566.1 COG3955 Exopolysaccharide biosynthesis protein; bicyclomycin/multidrug efflux system 815990 5225218 CGSHiEE_03970 Haemophilus influenzae PittEE bicyclomycin/multidrug efflux system YP_001290592.1 815400 R 374930 CDS YP_001290593.1 148825840 5225219 816219..818489 1 NC_009566.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 818489 5225219 CGSHiEE_03975 Haemophilus influenzae PittEE malic enzyme YP_001290593.1 816219 D 374930 CDS YP_001290594.1 148825841 5225220 complement(823328..824296) 1 NC_009566.1 hypothetical protein 824296 5225220 CGSHiEE_04000 Haemophilus influenzae PittEE hypothetical protein YP_001290594.1 823328 R 374930 CDS YP_001290595.1 148825842 5225221 complement(824299..824919) 1 NC_009566.1 hypothetical protein 824919 5225221 CGSHiEE_04005 Haemophilus influenzae PittEE hypothetical protein YP_001290595.1 824299 R 374930 CDS YP_001290596.1 148825843 5225296 825243..825548 1 NC_009566.1 hypothetical protein 825548 5225296 CGSHiEE_04010 Haemophilus influenzae PittEE hypothetical protein YP_001290596.1 825243 D 374930 CDS YP_001290597.1 148825844 5225297 825559..825882 1 NC_009566.1 hypothetical protein 825882 5225297 CGSHiEE_04015 Haemophilus influenzae PittEE hypothetical protein YP_001290597.1 825559 D 374930 CDS YP_001290598.1 148825845 5225298 826045..827715 1 NC_009566.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein 827715 5225298 CGSHiEE_04020 Haemophilus influenzae PittEE putative ABC transporter ATP-binding protein YP_001290598.1 826045 D 374930 CDS YP_001290599.1 148825846 5225299 827777..828118 1 NC_009566.1 hypothetical protein 828118 5225299 CGSHiEE_04025 Haemophilus influenzae PittEE hypothetical protein YP_001290599.1 827777 D 374930 CDS YP_001290600.1 148825847 5225300 828123..830093 1 NC_009566.1 P-loop ATPase fused to an acetyltransferase 830093 5225300 CGSHiEE_04030 Haemophilus influenzae PittEE P-loop ATPase fused to an acetyltransferase YP_001290600.1 828123 D 374930 CDS YP_001290601.1 148825848 5225301 830090..830263 1 NC_009566.1 COG1444 Predicted P-loop ATPase fused to an acetyltransferase; hypothetical protein 830263 5225301 CGSHiEE_04035 Haemophilus influenzae PittEE hypothetical protein YP_001290601.1 830090 D 374930 CDS YP_001290602.1 148825849 5224800 830365..833805 1 NC_009566.1 COG1197 Transcription-repair coupling factor (superfamily II helicase); transcription-repair coupling factor 833805 5224800 CGSHiEE_04040 Haemophilus influenzae PittEE transcription-repair coupling factor YP_001290602.1 830365 D 374930 CDS YP_001290603.1 148825850 5224801 complement(833858..835249) 1 NC_009566.1 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; periplasmic serine protease do/HhoA-like 835249 5224801 CGSHiEE_04045 Haemophilus influenzae PittEE periplasmic serine protease do/HhoA-like YP_001290603.1 833858 R 374930 CDS YP_001290604.1 148825851 5224804 835442..836332 1 NC_009566.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 836332 5224804 CGSHiEE_04050 Haemophilus influenzae PittEE acetyl-CoA carboxylase subunit beta YP_001290604.1 835442 D 374930 CDS YP_001290605.1 148825852 5224847 complement(838509..839189) 1 NC_009566.1 COG2949 Uncharacterized membrane protein; hypothetical protein 839189 5224847 CGSHiEE_04065 Haemophilus influenzae PittEE hypothetical protein YP_001290605.1 838509 R 374930 CDS YP_001290606.1 148825853 5224848 839347..840423 1 NC_009566.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase 840423 metX 5224848 metX Haemophilus influenzae PittEE homoserine O-acetyltransferase YP_001290606.1 839347 D 374930 CDS YP_001290607.1 148825854 5224849 complement(840478..843126) 1 NC_009566.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 843126 5224849 CGSHiEE_04075 Haemophilus influenzae PittEE DNA gyrase subunit A YP_001290607.1 840478 R 374930 CDS YP_001290608.1 148825855 5224850 843184..843420 1 NC_009566.1 COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit; hypothetical protein 843420 5224850 CGSHiEE_04080 Haemophilus influenzae PittEE hypothetical protein YP_001290608.1 843184 D 374930 CDS YP_001290609.1 148825856 5225302 complement(845627..846103) 1 NC_009566.1 COG1944 Uncharacterized conserved protein; hypothetical protein 846103 5225302 CGSHiEE_04095 Haemophilus influenzae PittEE hypothetical protein YP_001290609.1 845627 R 374930 CDS YP_001290610.1 148825857 5225303 846339..847145 1 NC_009566.1 COG0500 SAM-dependent methyltransferases; hypothetical protein 847145 5225303 CGSHiEE_04100 Haemophilus influenzae PittEE hypothetical protein YP_001290610.1 846339 D 374930 CDS YP_001290611.1 148825858 5225304 complement(847956..848816) 1 NC_009566.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 848816 5225304 CGSHiEE_04115 Haemophilus influenzae PittEE tellurite resistance protein TehB YP_001290611.1 847956 R 374930 CDS YP_001290612.1 148825859 5225305 complement(848929..850977) 1 NC_009566.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 850977 metG 5225305 metG Haemophilus influenzae PittEE methionyl-tRNA synthetase YP_001290612.1 848929 R 374930 CDS YP_001290613.1 148825860 5225306 851126..852238 1 NC_009566.1 COG0489 ATPases involved in chromosome partitioning; putative ATPase 852238 5225306 CGSHiEE_04125 Haemophilus influenzae PittEE putative ATPase YP_001290613.1 851126 D 374930 CDS YP_001290614.1 148825861 5226328 complement(852286..852948) 1 NC_009566.1 COG0778 Nitroreductase; putative NAD(P)H nitroreductase 852948 5226328 CGSHiEE_04130 Haemophilus influenzae PittEE putative NAD(P)H nitroreductase YP_001290614.1 852286 R 374930 CDS YP_001290615.1 148825862 5226329 853062..853736 1 NC_009566.1 COG1083 CMP-N-acetylneuraminic acid synthetase; acylneuraminate cytidylyltransferase 853736 5226329 CGSHiEE_04135 Haemophilus influenzae PittEE acylneuraminate cytidylyltransferase YP_001290615.1 853062 D 374930 CDS YP_001290616.1 148825863 5226330 854214..854330 1 NC_009566.1 transposase 854330 5226330 CGSHiEE_04140 Haemophilus influenzae PittEE transposase YP_001290616.1 854214 D 374930 CDS YP_001290618.1 148825865 5226332 855725..856180 1 NC_009566.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 856180 5226332 CGSHiEE_04150 Haemophilus influenzae PittEE hypothetical protein YP_001290618.1 855725 D 374930 CDS YP_001290619.1 148825866 5226333 856197..857684 1 NC_009566.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 857684 nusA 5226333 nusA Haemophilus influenzae PittEE transcription elongation factor NusA YP_001290619.1 856197 D 374930 CDS YP_001290620.1 148825867 5226176 857706..860216 1 NC_009566.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 860216 infB 5226176 infB Haemophilus influenzae PittEE translation initiation factor IF-2 YP_001290620.1 857706 D 374930 CDS YP_001290621.1 148825868 5226177 complement(860295..863480) 1 NC_009566.1 putative type I restriction enzyme HindVIIP R protein 863480 5226177 CGSHiEE_04165 Haemophilus influenzae PittEE putative type I restriction enzyme HindVIIP R protein YP_001290621.1 860295 R 374930 CDS YP_001290622.1 148825869 5226178 complement(863464..864501) 1 NC_009566.1 COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases; hypothetical protein 864501 5226178 CGSHiEE_04170 Haemophilus influenzae PittEE hypothetical protein YP_001290622.1 863464 R 374930 CDS YP_001290623.1 148825870 5226179 complement(864491..865894) 1 NC_009566.1 COG0732 Restriction endonuclease S subunits; type I restriction/modification specificity protein 865894 5226179 CGSHiEE_04175 Haemophilus influenzae PittEE type I restriction/modification specificity protein YP_001290623.1 864491 R 374930 CDS YP_001290624.1 148825871 5226180 complement(865887..867218) 1 NC_009566.1 translation initiation factor IF-2 867218 infB 5226180 infB Haemophilus influenzae PittEE translation initiation factor IF-2 YP_001290624.1 865887 R 374930 CDS YP_001290625.1 148825872 5226013 867723..868109 1 NC_009566.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 868109 rbfA 5226013 rbfA Haemophilus influenzae PittEE ribosome-binding factor A YP_001290625.1 867723 D 374930 CDS YP_001290626.1 148825873 5226014 868109..869029 1 NC_009566.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 869029 truB 5226014 truB Haemophilus influenzae PittEE tRNA pseudouridine synthase B YP_001290626.1 868109 D 374930 CDS YP_001290627.1 148825874 5226015 869118..870242 1 NC_009566.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 870242 tyrA 5226015 tyrA Haemophilus influenzae PittEE bifunctional chorismate mutase/prephenate dehydrogenase YP_001290627.1 869118 D 374930 CDS YP_001290628.1 148825875 5225920 complement(870275..871114) 1 NC_009566.1 related to GTP cyclohydrolase I; catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 871114 queF 5225920 queF Haemophilus influenzae PittEE 7-cyano-7-deazaguanine reductase YP_001290628.1 870275 R 374930 CDS YP_001290629.1 148825876 5225921 complement(871241..872026) 1 NC_009566.1 COG5595 Zn-ribbon-containing, possibly nucleic-acid-binding protein; hypothetical protein 872026 5225921 CGSHiEE_04205 Haemophilus influenzae PittEE hypothetical protein YP_001290629.1 871241 R 374930 CDS YP_001290630.1 148825877 5225922 complement(872017..872397) 1 NC_009566.1 COG2166 SufE protein probably involved in Fe-S center assembly; hypothetical protein 872397 5225922 CGSHiEE_04210 Haemophilus influenzae PittEE hypothetical protein YP_001290630.1 872017 R 374930 CDS YP_001290631.1 148825878 5225923 complement(872394..873593) 1 NC_009566.1 COG0520 Selenocysteine lyase; putative selenocysteine lyase 873593 5225923 CGSHiEE_04215 Haemophilus influenzae PittEE putative selenocysteine lyase YP_001290631.1 872394 R 374930 CDS YP_001290632.1 148825879 5225924 complement(873595..874056) 1 NC_009566.1 COG1525 Micrococcal nuclease (thermonuclease) homologs; 7-cyano-7-deazaguanine reductase 874056 queF 5225924 queF Haemophilus influenzae PittEE 7-cyano-7-deazaguanine reductase YP_001290632.1 873595 R 374930 CDS YP_001290633.1 148825880 5225925 874192..874623 1 NC_009566.1 COG1380 Putative effector of murein hydrolase LrgA; hypothetical protein 874623 5225925 CGSHiEE_04225 Haemophilus influenzae PittEE hypothetical protein YP_001290633.1 874192 D 374930 CDS YP_001290634.1 148825881 5225826 874634..875329 1 NC_009566.1 COG1346 Putative effector of murein hydrolase; hypothetical protein 875329 5225826 CGSHiEE_04230 Haemophilus influenzae PittEE hypothetical protein YP_001290634.1 874634 D 374930 CDS YP_001290635.1 148825882 5225827 875422..876807 1 NC_009566.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein 876807 5225827 CGSHiEE_04235 Haemophilus influenzae PittEE deoxyguanosinetriphosphate triphosphohydrolase-like protein YP_001290635.1 875422 D 374930 CDS YP_001290636.1 148825883 5225828 876901..878844 1 NC_009566.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 878844 5225828 CGSHiEE_04240 Haemophilus influenzae PittEE ABC transporter ATPase YP_001290636.1 876901 D 374930 CDS YP_001290637.1 148825884 5225829 complement(878925..880007) 1 NC_009566.1 COG0687 Spermidine/putrescine-binding periplasmic protein; ABC transporter ATPase 880007 5225829 CGSHiEE_04245 Haemophilus influenzae PittEE ABC transporter ATPase YP_001290637.1 878925 R 374930 CDS YP_001290638.1 148825885 5225830 complement(880139..880909) 1 NC_009566.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein 880909 potC 5225830 potC Haemophilus influenzae PittEE spermidine/putrescine ABC transporter membrane protein YP_001290638.1 880139 R 374930 CDS YP_001290639.1 148825886 5225831 complement(880909..881769) 1 NC_009566.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein 881769 potB 5225831 potB Haemophilus influenzae PittEE spermidine/putrescine ABC transporter membrane protein YP_001290639.1 880909 R 374930 CDS YP_001290640.1 148825887 5225711 complement(881753..882871) 1 NC_009566.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase protein 882871 potA 5225711 potA Haemophilus influenzae PittEE putrescine/spermidine ABC transporter ATPase protein YP_001290640.1 881753 R 374930 CDS YP_001290641.1 148825888 5225712 883168..884406 1 NC_009566.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 884406 5225712 CGSHiEE_04265 Haemophilus influenzae PittEE peptidase T YP_001290641.1 883168 D 374930 CDS YP_001290642.1 148825889 5225713 complement(884978..885460) 1 NC_009566.1 COG0783 DNA-binding ferritin-like protein (oxidative damage protectant); peptidase T 885460 5225713 CGSHiEE_04270 Haemophilus influenzae PittEE peptidase T YP_001290642.1 884978 R 374930 CDS YP_001290643.1 148825890 5225714 885734..886612 1 NC_009566.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 886612 5225714 CGSHiEE_04275 Haemophilus influenzae PittEE cytidine deaminase YP_001290643.1 885734 D 374930 CDS YP_001290644.1 148825891 5225715 complement(886656..887621) 1 NC_009566.1 COG0500 SAM-dependent methyltransferases; hypothetical protein 887621 5225715 CGSHiEE_04280 Haemophilus influenzae PittEE hypothetical protein YP_001290644.1 886656 R 374930 CDS YP_001290645.1 148825892 5225716 complement(887618..889132) 1 NC_009566.1 COG0591 Na+/proline symporter; cytidine deaminase 889132 5225716 CGSHiEE_04285 Haemophilus influenzae PittEE cytidine deaminase YP_001290645.1 887618 R 374930 CDS YP_001290646.1 148825893 5225615 889248..890723 1 NC_009566.1 involved in the processing of the 5'end of 16S rRNA; ribonuclease G 890723 5225615 CGSHiEE_04290 Haemophilus influenzae PittEE ribonuclease G YP_001290646.1 889248 D 374930 CDS YP_001290647.1 148825894 5225616 891268..892938 1 NC_009566.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 892938 5225616 CGSHiEE_04295 Haemophilus influenzae PittEE glutaminyl-tRNA synthetase YP_001290647.1 891268 D 374930 CDS YP_001290648.1 148825895 5225617 893016..893468 1 NC_009566.1 COG2983 Uncharacterized conserved protein; hypothetical protein 893468 5225617 CGSHiEE_04300 Haemophilus influenzae PittEE hypothetical protein YP_001290648.1 893016 D 374930 CDS YP_001290649.1 148825896 5225618 893539..895629 1 NC_009566.1 COG1640 4-alpha-glucanotransferase; hypothetical protein 895629 5225618 CGSHiEE_04305 Haemophilus influenzae PittEE hypothetical protein YP_001290649.1 893539 D 374930 CDS YP_001290650.1 148825897 5225619 897931..899907 1 NC_009566.1 COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases; glycogen branching enzyme 899907 5225619 CGSHiEE_04320 Haemophilus influenzae PittEE glycogen branching enzyme YP_001290650.1 897931 D 374930 CDS YP_001290651.1 148825898 5225604 899930..901231 1 NC_009566.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 901231 glgC 5225604 glgC Haemophilus influenzae PittEE glucose-1-phosphate adenylyltransferase YP_001290651.1 899930 D 374930 CDS YP_001290652.1 148825899 5225605 901339..902769 1 NC_009566.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 902769 glgA 5225605 glgA Haemophilus influenzae PittEE glycogen synthase YP_001290652.1 901339 D 374930 CDS YP_001290653.1 148825900 5225606 903016..905481 1 NC_009566.1 COG0058 Glucan phosphorylase; glycogen synthase 905481 glgA 5225606 glgA Haemophilus influenzae PittEE glycogen synthase YP_001290653.1 903016 D 374930 CDS YP_001290654.1 148825901 5225607 905742..907280 1 NC_009566.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 907280 pntA 5225607 pntA Haemophilus influenzae PittEE NAD(P) transhydrogenase subunit alpha YP_001290654.1 905742 D 374930 CDS YP_001290655.1 148825902 5225608 complement(908776..909693) 1 NC_009566.1 COG0583 Transcriptional regulator; pyridine nucleotide transhydrogenase 909693 pntB 5225608 pntB Haemophilus influenzae PittEE pyridine nucleotide transhydrogenase YP_001290655.1 908776 R 374930 CDS YP_001290656.1 148825903 5225433 909789..912395 1 NC_009566.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 912395 5225433 CGSHiEE_04360 Haemophilus influenzae PittEE DNA topoisomerase I YP_001290656.1 909789 D 374930 CDS YP_001290657.1 148825904 5225434 complement(912471..913055) 1 NC_009566.1 DNA topoisomerase I 913055 5225434 CGSHiEE_04365 Haemophilus influenzae PittEE DNA topoisomerase I YP_001290657.1 912471 R 374930 CDS YP_001290658.1 148825905 5225435 complement(913137..913340) 1 NC_009566.1 COG1182 Acyl carrier protein phosphodiesterase; hypothetical protein 913340 5225435 CGSHiEE_04370 Haemophilus influenzae PittEE hypothetical protein YP_001290658.1 913137 R 374930 CDS YP_001290659.1 148825906 5225436 913340..915271 1 NC_009566.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 915271 5225436 CGSHiEE_04375 Haemophilus influenzae PittEE threonyl-tRNA synthetase YP_001290659.1 913340 D 374930 CDS YP_001290660.1 148825907 5225437 complement(915394..918177) 1 NC_009566.1 COG0612 Predicted Zn-dependent peptidases; putative zinc protease 918177 5225437 CGSHiEE_04380 Haemophilus influenzae PittEE putative zinc protease YP_001290660.1 915394 R 374930 CDS YP_001290661.1 148825908 5225438 complement(920858..921067) 1 NC_009566.1 COG3585 Molybdopterin-binding protein; putative molybdenum-pterin binding protein 921067 5225438 CGSHiEE_04395 Haemophilus influenzae PittEE putative molybdenum-pterin binding protein YP_001290661.1 920858 R 374930 CDS YP_001290662.1 148825909 5225104 complement(921175..921504) 1 NC_009566.1 COG2920 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit; putative dissimilatory sulfite reductase, desulfoviridin subunit gamma 921504 5225104 CGSHiEE_04400 Haemophilus influenzae PittEE putative dissimilatory sulfite reductase, desulfoviridin subunit gamma YP_001290662.1 921175 R 374930 CDS YP_001290663.1 148825910 5225105 complement(921506..922336) 1 NC_009566.1 COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control; threonyl-tRNA synthetase 922336 5225105 CGSHiEE_04405 Haemophilus influenzae PittEE threonyl-tRNA synthetase YP_001290663.1 921506 R 374930 CDS YP_001290664.1 148825911 5225106 922587..923921 1 NC_009566.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 923921 5225106 CGSHiEE_04410 Haemophilus influenzae PittEE condesin subunit F YP_001290664.1 922587 D 374930 CDS YP_001290665.1 148825912 5225107 924070..924804 1 NC_009566.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 924804 5225107 CGSHiEE_04415 Haemophilus influenzae PittEE condesin subunit E YP_001290665.1 924070 D 374930 CDS YP_001290666.1 148825913 5225108 929407..930315 1 NC_009566.1 COG3586 Uncharacterized conserved protein; hypothetical protein 930315 5225108 CGSHiEE_04430 Haemophilus influenzae PittEE hypothetical protein YP_001290666.1 929407 D 374930 CDS YP_001290667.1 148825914 5225062 930318..931193 1 NC_009566.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; cell division protein MukB 931193 mukB 5225062 mukB Haemophilus influenzae PittEE cell division protein MukB YP_001290667.1 930318 D 374930 CDS YP_001290668.1 148825915 5225063 931206..932627 1 NC_009566.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 932627 sbcB 5225063 sbcB Haemophilus influenzae PittEE exonuclease I YP_001290668.1 931206 D 374930 CDS YP_001290669.1 148825916 5225064 complement(933316..934593) 1 NC_009566.1 COG0642 Signal transduction histidine kinase; phosphate regulon sensor protein PhoR 934593 5225064 CGSHiEE_04445 Haemophilus influenzae PittEE phosphate regulon sensor protein PhoR YP_001290669.1 933316 R 374930 CDS YP_001290670.1 148825917 5225065 complement(934590..935285) 1 NC_009566.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; phosphate regulon transcriptional regulatory protein PhoB 935285 5225065 CGSHiEE_04450 Haemophilus influenzae PittEE phosphate regulon transcriptional regulatory protein PhoB YP_001290670.1 934590 R 374930 CDS YP_001290671.1 148825918 5225066 complement(935382..936149) 1 NC_009566.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 936149 5225066 CGSHiEE_04455 Haemophilus influenzae PittEE phosphate transporter ATP-binding protein YP_001290671.1 935382 R 374930 CDS YP_001290672.1 148825919 5224829 complement(936159..937007) 1 NC_009566.1 COG0581 ABC-type phosphate transport system, permease component; phosphate transport system permease protein PstA 937007 5224829 CGSHiEE_04460 Haemophilus influenzae PittEE phosphate transport system permease protein PstA YP_001290672.1 936159 R 374930 CDS YP_001290673.1 148825920 5224830 complement(937009..937884) 1 NC_009566.1 COG0573 ABC-type phosphate transport system, permease component; phosphate transport system permease protein PstC 937884 5224830 CGSHiEE_04465 Haemophilus influenzae PittEE phosphate transport system permease protein PstC YP_001290673.1 937009 R 374930 CDS YP_001290674.1 148825921 5224831 complement(938049..939068) 1 NC_009566.1 COG0226 ABC-type phosphate transport system, periplasmic component; phosphate-binding periplasmic protein PstS 939068 5224831 CGSHiEE_04470 Haemophilus influenzae PittEE phosphate-binding periplasmic protein PstS YP_001290674.1 938049 R 374930 CDS YP_001290675.1 148825922 5224832 939573..940061 1 NC_009566.1 COG1528 Ferritin-like protein; ferritin like protein 1 940061 5224832 CGSHiEE_04475 Haemophilus influenzae PittEE ferritin like protein 1 YP_001290675.1 939573 D 374930 CDS YP_001290676.1 148825923 5224833 940081..940578 1 NC_009566.1 COG1528 Ferritin-like protein; ferritin 940578 5224833 CGSHiEE_04480 Haemophilus influenzae PittEE ferritin YP_001290676.1 940081 D 374930 CDS YP_001290677.1 148825924 5224834 940823..941587 1 NC_009566.1 COG0463 Glycosyltransferases involved in cell wall biogenesis; hypothetical protein 941587 5224834 CGSHiEE_04485 Haemophilus influenzae PittEE hypothetical protein YP_001290677.1 940823 D 374930 CDS YP_001290678.1 148825925 5225563 941692..943248 1 NC_009566.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 943248 sbcB 5225563 sbcB Haemophilus influenzae PittEE anthranilate synthase component I YP_001290678.1 941692 D 374930 CDS YP_001290679.1 148825926 5225564 943261..943842 1 NC_009566.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 943842 5225564 CGSHiEE_04495 Haemophilus influenzae PittEE anthranilate synthase component II YP_001290679.1 943261 D 374930 CDS YP_001290680.1 148825927 5225565 944329..945330 1 NC_009566.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 945330 trpD 5225565 trpD Haemophilus influenzae PittEE anthranilate phosphoribosyltransferase YP_001290680.1 944329 D 374930 CDS YP_001290681.1 148825928 5225566 945371..946801 1 NC_009566.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 946801 5225566 CGSHiEE_04515 Haemophilus influenzae PittEE bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase YP_001290681.1 945371 D 374930 CDS YP_001290682.1 148825929 5225567 946917..947189 1 NC_009566.1 COG0298 Hydrogenase maturation factor; hydrogenase 2 accessory protein HypG 947189 5225567 CGSHiEE_04520 Haemophilus influenzae PittEE hydrogenase 2 accessory protein HypG YP_001290682.1 946917 D 374930 CDS YP_001290683.1 148825930 5225361 complement(947221..950085) 1 NC_009566.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 950085 valS 5225361 valS Haemophilus influenzae PittEE valyl-tRNA synthetase YP_001290683.1 947221 R 374930 CDS YP_001290684.1 148825931 5225362 complement(950133..950771) 1 NC_009566.1 COG0525 Valyl-tRNA synthetase; valyl-tRNA synthetase 950771 valS 5225362 valS Haemophilus influenzae PittEE valyl-tRNA synthetase YP_001290684.1 950133 R 374930 CDS YP_001290685.1 148825932 5225363 complement(950794..951108) 1 NC_009566.1 hypothetical protein 951108 5225363 CGSHiEE_04535 Haemophilus influenzae PittEE hypothetical protein YP_001290685.1 950794 R 374930 CDS YP_001290686.1 148825933 5225364 complement(951135..951302) 1 NC_009566.1 COG3097 Uncharacterized protein conserved in bacteria; hypothetical protein 951302 5225364 CGSHiEE_04540 Haemophilus influenzae PittEE hypothetical protein YP_001290686.1 951135 R 374930 CDS YP_001290687.1 148825934 5225365 complement(951316..951729) 1 NC_009566.1 hypothetical protein 951729 5225365 CGSHiEE_04545 Haemophilus influenzae PittEE hypothetical protein YP_001290687.1 951316 R 374930 CDS YP_001290688.1 148825935 5225366 complement(951719..951889) 1 NC_009566.1 COG4185 Uncharacterized protein conserved in bacteria; hypothetical protein 951889 5225366 CGSHiEE_04550 Haemophilus influenzae PittEE hypothetical protein YP_001290688.1 951719 R 374930 CDS YP_001290689.1 148825936 5226016 complement(951974..952408) 1 NC_009566.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 952408 5226016 CGSHiEE_04555 Haemophilus influenzae PittEE DNA polymerase III subunit chi YP_001290689.1 951974 R 374930 CDS YP_001290690.1 148825937 5226017 complement(952500..952673) 1 NC_009566.1 COG0136 Aspartate-semialdehyde dehydrogenase; aspartate-semialdehyde dehydrogenase 952673 5226017 CGSHiEE_04560 Haemophilus influenzae PittEE aspartate-semialdehyde dehydrogenase YP_001290690.1 952500 R 374930 CDS YP_001290691.1 148825938 5226018 953053..953955 1 NC_009566.1 COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases; aspartate-semialdehyde dehydrogenase 953955 5226018 CGSHiEE_04565 Haemophilus influenzae PittEE aspartate-semialdehyde dehydrogenase YP_001290691.1 953053 D 374930 CDS YP_001290692.1 148825939 5226019 954105..955499 1 NC_009566.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 955499 fumC 5226019 fumC Haemophilus influenzae PittEE fumarate hydratase YP_001290692.1 954105 D 374930 CDS YP_001290693.1 148825940 5226020 955627..956235 1 NC_009566.1 COG0114 Fumarase; hypothetical protein 956235 5226020 CGSHiEE_04575 Haemophilus influenzae PittEE hypothetical protein YP_001290693.1 955627 D 374930 CDS YP_001290694.1 148825941 5226021 complement(956333..957157) 1 NC_009566.1 COG0613 Predicted metal-dependent phosphoesterases (PHP family); fumarate hydratase 957157 fumC 5226021 fumC Haemophilus influenzae PittEE fumarate hydratase YP_001290694.1 956333 R 374930 CDS YP_001290695.1 148825942 5226247 complement(957157..958176) 1 NC_009566.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 958176 5226247 CGSHiEE_04585 Haemophilus influenzae PittEE dihydroorotate dehydrogenase 2 YP_001290695.1 957157 R 374930 CDS YP_001290696.1 148825943 5226248 958659..958841 1 NC_009566.1 COG0167 Dihydroorotate dehydrogenase; hypothetical protein 958841 5226248 CGSHiEE_04590 Haemophilus influenzae PittEE hypothetical protein YP_001290696.1 958659 D 374930 CDS YP_001290697.1 148825944 5226249 complement(958885..959334) 1 NC_009566.1 COG1598 Uncharacterized conserved protein; hypothetical protein 959334 5226249 CGSHiEE_04595 Haemophilus influenzae PittEE hypothetical protein YP_001290697.1 958885 R 374930 CDS YP_001290698.1 148825945 5226250 complement(959366..959548) 1 NC_009566.1 COG1724 Predicted periplasmic or secreted lipoprotein; hypothetical protein 959548 5226250 CGSHiEE_04600 Haemophilus influenzae PittEE hypothetical protein YP_001290698.1 959366 R 374930 CDS YP_001290699.1 148825946 5226251 complement(959705..960316) 1 NC_009566.1 hypothetical protein 960316 5226251 CGSHiEE_04605 Haemophilus influenzae PittEE hypothetical protein YP_001290699.1 959705 R 374930 CDS YP_001290700.1 148825947 5226252 complement(960364..960660) 1 NC_009566.1 COG3646 Uncharacterized phage-encoded protein; hypothetical protein 960660 5226252 CGSHiEE_04610 Haemophilus influenzae PittEE hypothetical protein YP_001290700.1 960364 R 374930 CDS YP_001290701.1 148825948 5225131 complement(960681..960887) 1 NC_009566.1 COG1396 Predicted transcriptional regulators; putative Cro repressor 960887 5225131 CGSHiEE_04615 Haemophilus influenzae PittEE putative Cro repressor YP_001290701.1 960681 R 374930 CDS YP_001290702.1 148825949 5225132 961018..961674 1 NC_009566.1 COG1396 Predicted transcriptional regulators; putative prophage repressor CI 961674 5225132 CGSHiEE_04620 Haemophilus influenzae PittEE putative prophage repressor CI YP_001290702.1 961018 D 374930 CDS YP_001290703.1 148825950 5225133 961742..962671 1 NC_009566.1 hypothetical protein 962671 5225133 CGSHiEE_04625 Haemophilus influenzae PittEE hypothetical protein YP_001290703.1 961742 D 374930 CDS YP_001290704.1 148825951 5225134 962652..963209 1 NC_009566.1 COG0419 ATPase involved in DNA repair; hypothetical protein 963209 5225134 CGSHiEE_04630 Haemophilus influenzae PittEE hypothetical protein YP_001290704.1 962652 D 374930 CDS YP_001290705.1 148825952 5225135 complement(963630..963800) 1 NC_009566.1 hypothetical protein 963800 5225135 CGSHiEE_04635 Haemophilus influenzae PittEE hypothetical protein YP_001290705.1 963630 R 374930 CDS YP_001290706.1 148825953 5225136 963815..964036 1 NC_009566.1 hypothetical protein 964036 5225136 CGSHiEE_04640 Haemophilus influenzae PittEE hypothetical protein YP_001290706.1 963815 D 374930 CDS YP_001290707.1 148825954 5225609 964204..964419 1 NC_009566.1 hypothetical protein 964419 5225609 CGSHiEE_04645 Haemophilus influenzae PittEE hypothetical protein YP_001290707.1 964204 D 374930 CDS YP_001290708.1 148825955 5225610 964451..964603 1 NC_009566.1 hypothetical protein 964603 5225610 CGSHiEE_04650 Haemophilus influenzae PittEE hypothetical protein YP_001290708.1 964451 D 374930 CDS YP_001290709.1 148825956 5225611 complement(964589..964855) 1 NC_009566.1 hypothetical protein 964855 5225611 CGSHiEE_04655 Haemophilus influenzae PittEE hypothetical protein YP_001290709.1 964589 R 374930 CDS YP_001290710.1 148825957 5225612 965117..965608 1 NC_009566.1 hypothetical protein 965608 5225612 CGSHiEE_04660 Haemophilus influenzae PittEE hypothetical protein YP_001290710.1 965117 D 374930 CDS YP_001290711.1 148825958 5225613 965612..965704 1 NC_009566.1 COG3422 Uncharacterized conserved protein; hypothetical protein 965704 5225613 CGSHiEE_04665 Haemophilus influenzae PittEE hypothetical protein YP_001290711.1 965612 D 374930 CDS YP_001290712.1 148825959 5225614 966042..966293 1 NC_009566.1 phage anti-repressor protein 966293 5225614 CGSHiEE_04670 Haemophilus influenzae PittEE phage anti-repressor protein YP_001290712.1 966042 D 374930 CDS YP_001290713.1 148825960 5224669 966646..966864 1 NC_009566.1 COG3561 Phage anti-repressor protein; hypothetical protein 966864 5224669 CGSHiEE_04675 Haemophilus influenzae PittEE hypothetical protein YP_001290713.1 966646 D 374930 CDS YP_001290714.1 148825961 5224670 complement(966861..967259) 1 NC_009566.1 integrase/recombinase 967259 5224670 CGSHiEE_04680 Haemophilus influenzae PittEE integrase/recombinase YP_001290714.1 966861 R 374930 CDS YP_001290715.1 148825962 5224671 complement(967256..967417) 1 NC_009566.1 COG0582 Integrase; integrase/recombinase 967417 5224671 CGSHiEE_04685 Haemophilus influenzae PittEE integrase/recombinase YP_001290715.1 967256 R 374930 CDS YP_001290716.1 148825963 5224672 complement(967427..967720) 1 NC_009566.1 dihydroorotate dehydrogenase 2 967720 5224672 CGSHiEE_04690 Haemophilus influenzae PittEE dihydroorotate dehydrogenase 2 YP_001290716.1 967427 R 374930 CDS YP_001290718.1 148825965 5224674 968302..969075 1 NC_009566.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 969075 5224674 CGSHiEE_04700 Haemophilus influenzae PittEE fumarate/nitrate reduction transcriptional regulator YP_001290718.1 968302 D 374930 CDS YP_001290719.1 148825966 5224746 969104..969295 1 NC_009566.1 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases; universal stress protein UspE 969295 5224746 CGSHiEE_04705 Haemophilus influenzae PittEE universal stress protein UspE YP_001290719.1 969104 D 374930 CDS YP_001290720.1 148825967 5224747 969276..970124 1 NC_009566.1 with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 970124 5224747 CGSHiEE_04710 Haemophilus influenzae PittEE universal stress protein UspE YP_001290720.1 969276 D 374930 CDS YP_001290721.1 148825968 5224748 970326..971162 1 NC_009566.1 COG5266 ABC-type Co2+ transport system, periplasmic component; universal stress protein UspE 971162 5224748 CGSHiEE_04715 Haemophilus influenzae PittEE universal stress protein UspE YP_001290721.1 970326 D 374930 CDS YP_001290722.1 148825969 5224749 complement(971246..971884) 1 NC_009566.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 971884 purN 5224749 purN Haemophilus influenzae PittEE phosphoribosylglycinamide formyltransferase YP_001290722.1 971246 R 374930 CDS YP_001290723.1 148825970 5224750 complement(971939..972973) 1 NC_009566.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 972973 5224750 CGSHiEE_04725 Haemophilus influenzae PittEE phosphoribosylaminoimidazole synthetase YP_001290723.1 971939 R 374930 CDS YP_001290724.1 148825971 5224751 973929..975122 1 NC_009566.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 975122 5224751 CGSHiEE_04740 Haemophilus influenzae PittEE tryptophan synthase subunit beta YP_001290724.1 973929 D 374930 CDS YP_001290725.1 148825972 5225811 975122..975928 1 NC_009566.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 975928 trpA 5225811 trpA Haemophilus influenzae PittEE tryptophan synthase subunit alpha YP_001290725.1 975122 D 374930 CDS YP_001290726.1 148825973 5225812 complement(976072..977025) 1 NC_009566.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 977025 5225812 CGSHiEE_04750 Haemophilus influenzae PittEE aspartate-semialdehyde dehydrogenase YP_001290726.1 976072 R 374930 CDS YP_001290727.1 148825974 5225813 977084..977560 1 NC_009566.1 COG2606 Uncharacterized conserved protein; hypothetical protein 977560 5225813 CGSHiEE_04755 Haemophilus influenzae PittEE hypothetical protein YP_001290727.1 977084 D 374930 CDS YP_001290728.1 148825975 5225814 complement(977717..977935) 1 NC_009566.1 COG1278 Cold shock proteins; aspartate-semialdehyde dehydrogenase 977935 5225814 CGSHiEE_04760 Haemophilus influenzae PittEE aspartate-semialdehyde dehydrogenase YP_001290728.1 977717 R 374930 CDS YP_001290729.1 148825976 5225815 complement(978082..978240) 1 NC_009566.1 COG3140 Uncharacterized protein conserved in bacteria; hypothetical protein 978240 5225815 CGSHiEE_04765 Haemophilus influenzae PittEE hypothetical protein YP_001290729.1 978082 R 374930 CDS YP_001290730.1 148825977 5225816 complement(978233..978952) 1 NC_009566.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C 978952 5225816 CGSHiEE_04770 Haemophilus influenzae PittEE tRNA pseudouridine synthase C YP_001290730.1 978233 R 374930 CDS YP_001290731.1 148825978 5225817 complement(978946..979266) 1 NC_009566.1 COG3098 Uncharacterized protein conserved in bacteria; hypothetical protein 979266 5225817 CGSHiEE_04775 Haemophilus influenzae PittEE hypothetical protein YP_001290731.1 978946 R 374930 CDS YP_001290732.1 148825979 5226043 complement(979281..980738) 1 NC_009566.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 980738 5226043 CGSHiEE_04780 Haemophilus influenzae PittEE thiamine biosynthesis protein ThiI YP_001290732.1 979281 R 374930 CDS YP_001290733.1 148825980 5226044 980897..981151 1 NC_009566.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 981151 5226044 CGSHiEE_04785 Haemophilus influenzae PittEE exodeoxyribonuclease VII small subunit YP_001290733.1 980897 D 374930 CDS YP_001290734.1 148825981 5226045 981151..982041 1 NC_009566.1 COG0142 Geranylgeranyl pyrophosphate synthase; exodeoxyribonuclease VII small subunit 982041 5226045 CGSHiEE_04790 Haemophilus influenzae PittEE exodeoxyribonuclease VII small subunit YP_001290734.1 981151 D 374930 CDS YP_001290735.1 148825982 5226046 982083..983960 1 NC_009566.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 983960 5226046 CGSHiEE_04795 Haemophilus influenzae PittEE 1-deoxy-D-xylulose-5-phosphate synthase YP_001290735.1 982083 D 374930 CDS YP_001290736.1 148825983 5226047 complement(983996..984448) 1 NC_009566.1 COG2969 Stringent starvation protein B; ClpXP protease specificity-enhancing factor 984448 5226047 CGSHiEE_04800 Haemophilus influenzae PittEE ClpXP protease specificity-enhancing factor YP_001290736.1 983996 R 374930 CDS YP_001290737.1 148825984 5226048 complement(984448..985086) 1 NC_009566.1 COG0625 Glutathione S-transferase; ClpXP protease specificity-enhancing factor 985086 5226048 CGSHiEE_04805 Haemophilus influenzae PittEE ClpXP protease specificity-enhancing factor YP_001290737.1 984448 R 374930 CDS YP_001290738.1 148825985 5226049 complement(985266..985658) 1 NC_009566.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 985658 rpsI 5226049 rpsI Haemophilus influenzae PittEE 30S ribosomal protein S9 YP_001290738.1 985266 R 374930 CDS YP_001290739.1 148825986 5225367 complement(985675..986103) 1 NC_009566.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 986103 rplM 5225367 rplM Haemophilus influenzae PittEE 50S ribosomal protein L13 YP_001290739.1 985675 R 374930 CDS YP_001290740.1 148825987 5225368 986568..987446 1 NC_009566.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 987446 metF 5225368 metF Haemophilus influenzae PittEE 5,10-methylenetetrahydrofolate reductase YP_001290740.1 986568 D 374930 CDS YP_001290741.1 148825988 5225369 complement(987535..988263) 1 NC_009566.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 988263 bioD 5225369 bioD Haemophilus influenzae PittEE dithiobiotin synthetase YP_001290741.1 987535 R 374930 CDS YP_001290742.1 148825989 5225370 complement(988365..988631) 1 NC_009566.1 COG3100 Uncharacterized protein conserved in bacteria; dithiobiotin synthetase 988631 bioD 5225370 bioD Haemophilus influenzae PittEE dithiobiotin synthetase YP_001290742.1 988365 R 374930 CDS YP_001290743.1 148825990 5225371 complement(988692..989348) 1 NC_009566.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 989348 folE 5225371 folE Haemophilus influenzae PittEE GTP cyclohydrolase I YP_001290743.1 988692 R 374930 CDS YP_001290744.1 148825991 5225372 989485..990699 1 NC_009566.1 COG0303 Molybdopterin biosynthesis enzyme; GTP cyclohydrolase I 990699 folE 5225372 folE Haemophilus influenzae PittEE GTP cyclohydrolase I YP_001290744.1 989485 D 374930 CDS YP_001290745.1 148825992 5225373 990703..991434 1 NC_009566.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 991434 5225373 CGSHiEE_04845 Haemophilus influenzae PittEE molybdopterin biosynthesis protein MoeB YP_001290745.1 990703 D 374930 CDS YP_001290746.1 148825993 5225464 991571..991825 1 NC_009566.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 991825 5225464 CGSHiEE_04850 Haemophilus influenzae PittEE dsDNA-mimic protein YP_001290746.1 991571 D 374930 CDS YP_001290747.1 148825994 5225465 complement(992007..992477) 1 NC_009566.1 COG0526 Thiol-disulfide isomerase and thioredoxins; hypothetical protein 992477 5225465 CGSHiEE_04855 Haemophilus influenzae PittEE hypothetical protein YP_001290747.1 992007 R 374930 CDS YP_001290748.1 148825995 5225466 complement(992522..993163) 1 NC_009566.1 COG0785 Cytochrome c biogenesis protein; hypothetical protein 993163 5225466 CGSHiEE_04860 Haemophilus influenzae PittEE hypothetical protein YP_001290748.1 992522 R 374930 CDS YP_001290749.1 148825996 5225467 complement(993175..994236) 1 NC_009566.1 COG0225 Peptide methionine sulfoxide reductase; bifunctional methionine sulfoxide reductase A/B protein 994236 5225467 CGSHiEE_04865 Haemophilus influenzae PittEE bifunctional methionine sulfoxide reductase A/B protein YP_001290749.1 993175 R 374930 CDS YP_001290750.1 148825997 5225468 994411..995274 1 NC_009566.1 hypothetical protein 995274 5225468 CGSHiEE_04870 Haemophilus influenzae PittEE hypothetical protein YP_001290750.1 994411 D 374930 CDS YP_001290751.1 148825998 5225469 complement(995369..995542) 1 NC_009566.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; dsDNA-mimic protein 995542 5225469 CGSHiEE_04875 Haemophilus influenzae PittEE dsDNA-mimic protein YP_001290751.1 995369 R 374930 CDS YP_001290752.1 148825999 5225485 complement(995552..996097) 1 NC_009566.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor 996097 5225485 CGSHiEE_04880 Haemophilus influenzae PittEE RNA polymerase sigma factor YP_001290752.1 995552 R 374930 CDS YP_001290753.1 148826000 5225486 complement(996224..996373) 1 NC_009566.1 hypothetical protein 996373 5225486 CGSHiEE_04885 Haemophilus influenzae PittEE hypothetical protein YP_001290753.1 996224 R 374930 CDS YP_001290754.1 148826001 5225487 complement(996457..996609) 1 NC_009566.1 hypothetical protein 996609 5225487 CGSHiEE_04890 Haemophilus influenzae PittEE hypothetical protein YP_001290754.1 996457 R 374930 CDS YP_001290755.1 148826002 5225488 complement(996603..996755) 1 NC_009566.1 COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; hypothetical protein 996755 5225488 CGSHiEE_04895 Haemophilus influenzae PittEE hypothetical protein YP_001290755.1 996603 R 374930 CDS YP_001290756.1 148826003 5225489 996981..998345 1 NC_009566.1 hypothetical protein 998345 5225489 CGSHiEE_04900 Haemophilus influenzae PittEE hypothetical protein YP_001290756.1 996981 D 374930 CDS YP_001290757.1 148826004 5225490 complement(998423..998608) 1 NC_009566.1 COG1538 Outer membrane protein; hypothetical protein 998608 5225490 CGSHiEE_04905 Haemophilus influenzae PittEE hypothetical protein YP_001290757.1 998423 R 374930 CDS YP_001290758.1 148826005 5225491 complement(998610..998933) 1 NC_009566.1 COG0443 Molecular chaperone; hypothetical protein 998933 5225491 CGSHiEE_04910 Haemophilus influenzae PittEE hypothetical protein YP_001290758.1 998610 R 374930 CDS YP_001290759.1 148826006 5225853 complement(999169..999663) 1 NC_009566.1 COG2062 Phosphohistidine phosphatase SixA; hypothetical protein 999663 5225853 CGSHiEE_04915 Haemophilus influenzae PittEE hypothetical protein YP_001290759.1 999169 R 374930 CDS YP_001290760.1 148826007 5225854 complement(999722..1001059) 1 NC_009566.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 1001059 5225854 CGSHiEE_04920 Haemophilus influenzae PittEE phosphoglucosamine mutase YP_001290760.1 999722 R 374930 CDS YP_001290761.1 148826008 5225855 complement(1001097..1001924) 1 NC_009566.1 COG0294 Dihydropteroate synthase and related enzymes; dihydropteroate synthase 1001924 5225855 CGSHiEE_04925 Haemophilus influenzae PittEE dihydropteroate synthase YP_001290761.1 1001097 R 374930 CDS YP_001290762.1 148826009 5225856 complement(1004035..1004754) 1 NC_009566.1 COG0293 23S rRNA methylase; ribosomal RNA large subunit methyltransferase J 1004754 5225856 CGSHiEE_04940 Haemophilus influenzae PittEE ribosomal RNA large subunit methyltransferase J YP_001290762.1 1004035 R 374930 CDS YP_001290763.1 148826010 5225857 1004735..1005091 1 NC_009566.1 COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein; 23S rRNA methyltransferase J 1005091 rrmJ 5225857 rrmJ Haemophilus influenzae PittEE 23S rRNA methyltransferase J YP_001290763.1 1004735 D 374930 CDS YP_001290764.1 148826011 5226227 complement(1005131..1005607) 1 NC_009566.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1005607 greA 5226227 greA Haemophilus influenzae PittEE transcription elongation factor GreA YP_001290764.1 1005131 R 374930 CDS YP_001290765.1 148826012 5226228 1005771..1007210 1 NC_009566.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase/endopeptidase 1007210 5226228 CGSHiEE_04955 Haemophilus influenzae PittEE D-alanyl-D-alanine carboxypeptidase/endopeptidase YP_001290765.1 1005771 D 374930 CDS YP_001290766.1 148826013 5226229 1007262..1007573 1 NC_009566.1 insertion element IS1016 transposase 1007573 5226229 CGSHiEE_04960 Haemophilus influenzae PittEE insertion element IS1016 transposase YP_001290766.1 1007262 D 374930 CDS YP_001290767.1 148826014 5226230 1007539..1007910 1 NC_009566.1 COG3676 Transposase and inactivated derivatives; D-alanyl-D-alanine carboxypeptidase/endopeptidase 1007910 5226230 CGSHiEE_04965 Haemophilus influenzae PittEE D-alanyl-D-alanine carboxypeptidase/endopeptidase YP_001290767.1 1007539 D 374930 CDS YP_001290768.2 408843738 5226231 complement(<1007983..1008252) 1 NC_009566.1 insertion of T, right before stop codon, leading to extension by 24 aa; marked partial; 30S ribosomal protein S15 1008252 5226231 CGSHiEE_04970 Haemophilus influenzae PittEE 30S ribosomal protein S15 YP_001290768.2 <1007983 R 374930 CDS YP_001290769.1 148826016 5226232 complement(1008388..1008522) 1 NC_009566.1 COG0184 Ribosomal protein S15P/S13E; hypothetical protein 1008522 5226232 CGSHiEE_04975 Haemophilus influenzae PittEE hypothetical protein YP_001290769.1 1008388 R 374930 CDS YP_001290770.1 148826017 5226233 complement(1008522..1009247) 1 NC_009566.1 COG0515 Serine/threonine protein kinase; 30S ribosomal protein S15 1009247 rpsO 5226233 rpsO Haemophilus influenzae PittEE 30S ribosomal protein S15 YP_001290770.1 1008522 R 374930 CDS YP_001290771.1 148826018 5226299 complement(1009486..1009968) 1 NC_009566.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-(acyl carrier protein) dehydratase 1009968 5226299 CGSHiEE_04985 Haemophilus influenzae PittEE 3-hydroxydecanoyl-(acyl carrier protein) dehydratase YP_001290771.1 1009486 R 374930 CDS YP_001290772.1 148826019 5226300 complement(1010185..1011960) 1 NC_009566.1 COG1067 Predicted ATP-dependent protease; 3-hydroxydecanoyl-ACP dehydratase 1011960 5226300 CGSHiEE_04990 Haemophilus influenzae PittEE 3-hydroxydecanoyl-ACP dehydratase YP_001290772.1 1010185 R 374930 CDS YP_001290773.1 148826020 5226301 1012087..1012533 1 NC_009566.1 COG3120 Uncharacterized protein conserved in bacteria; hypothetical protein 1012533 5226301 CGSHiEE_04995 Haemophilus influenzae PittEE hypothetical protein YP_001290773.1 1012087 D 374930 CDS YP_001290774.1 148826021 5226302 complement(1012602..1014524) 1 NC_009566.1 COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member; exodeoxyribonuclease V subunit alpha 1014524 5226302 CGSHiEE_05000 Haemophilus influenzae PittEE exodeoxyribonuclease V subunit alpha YP_001290774.1 1012602 R 374930 CDS YP_001290775.1 148826022 5226303 complement(1014524..1018159) 1 NC_009566.1 COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains); hypothetical protein 1018159 5226303 CGSHiEE_05005 Haemophilus influenzae PittEE hypothetical protein YP_001290775.1 1014524 R 374930 CDS YP_001290776.1 148826023 5226304 complement(1018272..1018625) 1 NC_009566.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1018625 rplT 5226304 rplT Haemophilus influenzae PittEE 50S ribosomal protein L20 YP_001290776.1 1018272 R 374930 CDS YP_001290777.1 148826024 5225356 complement(1018691..1018960) 1 NC_009566.1 COG0291 Ribosomal protein L35; 50S ribosomal protein L35 1018960 rpmI 5225356 rpmI Haemophilus influenzae PittEE 50S ribosomal protein L35 YP_001290777.1 1018691 R 374930 CDS YP_001290778.1 148826025 5225357 complement(1019099..1019506) 1 NC_009566.1 COG0290 Translation initiation factor 3 (IF-3); translation initiation factor IF-3 1019506 5225357 CGSHiEE_05020 Haemophilus influenzae PittEE translation initiation factor IF-3 YP_001290778.1 1019099 R 374930 CDS YP_001290779.1 148826026 5225358 complement(1019775..1020587) 1 NC_009566.1 related to aldose 1-epimerase; COG0676 Uncharacterized enzymes related to aldose 1-epimerase; hypothetical protein 1020587 5225358 CGSHiEE_05025 Haemophilus influenzae PittEE hypothetical protein YP_001290779.1 1019775 R 374930 CDS YP_001290780.1 148826027 5225359 complement(1022309..1023178) 1 NC_009566.1 serine/threonine protein phosphatase family protein 1023178 5225359 CGSHiEE_05050 Haemophilus influenzae PittEE serine/threonine protein phosphatase family protein YP_001290780.1 1022309 R 374930 CDS YP_001290781.1 148826028 5225360 complement(1023254..1024228) 1 NC_009566.1 COG0466 ATP-dependent Lon protease, bacterial type; hypothetical protein 1024228 5225360 CGSHiEE_05055 Haemophilus influenzae PittEE hypothetical protein YP_001290781.1 1023254 R 374930 CDS YP_001290782.1 148826029 5225864 complement(1024306..1025067) 1 NC_009566.1 COG0631 Serine/threonine protein phosphatase; hypothetical protein 1025067 5225864 CGSHiEE_05060 Haemophilus influenzae PittEE hypothetical protein YP_001290782.1 1024306 R 374930 CDS YP_001290783.1 148826030 5225865 complement(1025067..1025912) 1 NC_009566.1 COG0846 NAD-dependent protein deacetylases, SIR2 family; NAD-dependent deacetylase sirtuin 5 1025912 5225865 CGSHiEE_05065 Haemophilus influenzae PittEE NAD-dependent deacetylase sirtuin 5 YP_001290783.1 1025067 R 374930 CDS YP_001290784.1 148826031 5225866 complement(1025909..1026109) 1 NC_009566.1 COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins; DNA translocase FtsK 1026109 5225866 CGSHiEE_05070 Haemophilus influenzae PittEE DNA translocase FtsK YP_001290784.1 1025909 R 374930 CDS YP_001290785.1 148826032 5225867 1026328..1027338 1 NC_009566.1 hypothetical protein 1027338 5225867 CGSHiEE_05075 Haemophilus influenzae PittEE hypothetical protein YP_001290785.1 1026328 D 374930 CDS YP_001290786.1 148826033 5225868 complement(1027386..1028102) 1 NC_009566.1 COG3943 Virulence protein; hypothetical protein 1028102 5225868 CGSHiEE_05080 Haemophilus influenzae PittEE hypothetical protein YP_001290786.1 1027386 R 374930 CDS YP_001290787.1 148826034 5225869 complement(1028116..1028610) 1 NC_009566.1 COG0462 Phosphoribosylpyrophosphate synthetase; hypothetical protein 1028610 5225869 CGSHiEE_05085 Haemophilus influenzae PittEE hypothetical protein YP_001290787.1 1028116 R 374930 CDS YP_001290788.1 148826035 5226126 complement(1028689..1029399) 1 NC_009566.1 COG0846 NAD-dependent protein deacetylases, SIR2 family; NAD-dependent deacetylase 1029399 5226126 CGSHiEE_05090 Haemophilus influenzae PittEE NAD-dependent deacetylase YP_001290788.1 1028689 R 374930 CDS YP_001290789.1 148826036 5226127 complement(1029383..1029838) 1 NC_009566.1 COG4502 Uncharacterized protein conserved in bacteria; putative 5'(3')-deoxyribonucleotidase 1029838 5226127 CGSHiEE_05095 Haemophilus influenzae PittEE putative 5'(3')-deoxyribonucleotidase YP_001290789.1 1029383 R 374930 CDS YP_001290790.1 148826037 5226128 complement(1029897..1030850) 1 NC_009566.1 COG2378 Predicted transcriptional regulator; hypothetical protein 1030850 5226128 CGSHiEE_05100 Haemophilus influenzae PittEE hypothetical protein YP_001290790.1 1029897 R 374930 CDS YP_001290791.1 148826038 5226129 complement(1030917..1031402) 1 NC_009566.1 COG0791 Cell wall-associated hydrolases (invasion-associated proteins); lipoprotein 1031402 5226129 CGSHiEE_05105 Haemophilus influenzae PittEE lipoprotein YP_001290791.1 1030917 R 374930 CDS YP_001290792.1 148826039 5226130 complement(1031455..1031745) 1 NC_009566.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 1031745 ihfA 5226130 ihfA Haemophilus influenzae PittEE integration host factor subunit alpha YP_001290792.1 1031455 R 374930 CDS YP_001290793.1 148826040 5226131 complement(1031747..1034134) 1 NC_009566.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1034134 pheT 5226131 pheT Haemophilus influenzae PittEE phenylalanyl-tRNA synthetase subunit beta YP_001290793.1 1031747 R 374930 CDS YP_001290794.1 148826041 5226132 complement(1034169..1035158) 1 NC_009566.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1035158 pheS 5226132 pheS Haemophilus influenzae PittEE phenylalanyl-tRNA synthetase subunit alpha YP_001290794.1 1034169 R 374930 CDS YP_001290795.1 148826042 5226202 complement(1035307..1036047) 1 NC_009566.1 COG0016 Phenylalanyl-tRNA synthetase alpha subunit; hypothetical protein 1036047 5226202 CGSHiEE_05125 Haemophilus influenzae PittEE hypothetical protein YP_001290795.1 1035307 R 374930 CDS YP_001290796.1 148826043 5226203 1036093..1036341 1 NC_009566.1 COG0633 Ferredoxin; phenylalanyl-tRNA synthetase subunit alpha 1036341 pheS 5226203 pheS Haemophilus influenzae PittEE phenylalanyl-tRNA synthetase subunit alpha YP_001290796.1 1036093 D 374930 CDS YP_001290797.1 148826044 5226204 complement(1036336..1037148) 1 NC_009566.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 1037148 5226204 CGSHiEE_05135 Haemophilus influenzae PittEE dihydrodipicolinate reductase YP_001290797.1 1036336 R 374930 CDS YP_001290798.1 148826045 5226205 complement(1037284..1037796) 1 NC_009566.1 COG1280 Putative threonine efflux protein; threonine efflux protein 1037796 5226205 CGSHiEE_05140 Haemophilus influenzae PittEE threonine efflux protein YP_001290798.1 1037284 R 374930 CDS YP_001290799.1 148826046 5226206 complement(1037796..1038287) 1 NC_009566.1 COG1267 Phosphatidylglycerophosphatase A and related proteins; phosphatidylglycerophosphatase A 1038287 5226206 CGSHiEE_05145 Haemophilus influenzae PittEE phosphatidylglycerophosphatase A YP_001290799.1 1037796 R 374930 CDS YP_001290800.1 148826047 5226207 complement(1038284..1039270) 1 NC_009566.1 COG0611 Thiamine monophosphate kinase; dihydrodipicolinate reductase 1039270 5226207 CGSHiEE_05150 Haemophilus influenzae PittEE dihydrodipicolinate reductase YP_001290800.1 1038284 R 374930 CDS YP_001290801.1 148826048 5225832 complement(1039337..1039771) 1 NC_009566.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 1039771 nusB 5225832 nusB Haemophilus influenzae PittEE transcription antitermination protein NusB YP_001290801.1 1039337 R 374930 CDS YP_001290802.1 148826049 5225833 complement(1039775..1040248) 1 NC_009566.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 1040248 ribH 5225833 ribH Haemophilus influenzae PittEE 6,7-dimethyl-8-ribityllumazine synthase YP_001290802.1 1039775 R 374930 CDS YP_001290803.1 148826050 5225834 1040475..1041878 1 NC_009566.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 1041878 asnC 5225834 asnC Haemophilus influenzae PittEE asparaginyl-tRNA synthetase YP_001290803.1 1040475 D 374930 CDS YP_001290804.1 148826051 5225835 1041954..1042643 1 NC_009566.1 COG0288 Carbonic anhydrase; putative carbonic anhydrase 1042643 5225835 CGSHiEE_05170 Haemophilus influenzae PittEE putative carbonic anhydrase YP_001290804.1 1041954 D 374930 CDS YP_001290805.1 148826052 5225836 1043743..1044099 1 NC_009566.1 hypothetical protein 1044099 5225836 CGSHiEE_05190 Haemophilus influenzae PittEE hypothetical protein YP_001290805.1 1043743 D 374930 CDS YP_001290806.1 148826053 5225882 1044310..1044405 1 NC_009566.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains; ABC transporter ATPase 1044405 5225882 CGSHiEE_05195 Haemophilus influenzae PittEE ABC transporter ATPase YP_001290806.1 1044310 D 374930 CDS YP_001290807.1 148826054 5225883 complement(1044769..1046199) 1 NC_009566.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 1046199 5225883 CGSHiEE_05200 Haemophilus influenzae PittEE bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase YP_001290807.1 1044769 R 374930 CDS YP_001290808.1 148826055 5225884 1047306..1049204 1 NC_009566.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 1049204 5225884 CGSHiEE_05215 Haemophilus influenzae PittEE DNA topoisomerase IV subunit B YP_001290808.1 1047306 D 374930 CDS YP_001290809.1 148826056 5225885 1051557..1052771 1 NC_009566.1 COG0786 Na+/glutamate symporter; sodium/glutamate symport carrier protein 1052771 5225885 CGSHiEE_05230 Haemophilus influenzae PittEE sodium/glutamate symport carrier protein YP_001290809.1 1051557 D 374930 CDS YP_001290810.1 148826057 5226140 complement(1052809..1053705) 1 NC_009566.1 COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); DNA topoisomerase IV subunit A 1053705 5226140 CGSHiEE_05235 Haemophilus influenzae PittEE DNA topoisomerase IV subunit A YP_001290810.1 1052809 R 374930 CDS YP_001290811.1 148826058 5226141 1053834..1054097 1 NC_009566.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 1 1054097 grxA 5226141 grxA Haemophilus influenzae PittEE glutaredoxin 1 YP_001290811.1 1053834 D 374930 CDS YP_001290812.1 148826059 5226142 complement(1054160..1055380) 1 NC_009566.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase I 1055380 5226142 CGSHiEE_05245 Haemophilus influenzae PittEE 3-oxoacyl-(acyl carrier protein) synthase I YP_001290812.1 1054160 R 374930 CDS YP_001290813.1 148826060 5226143 1055527..1057539 1 NC_009566.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 1057539 mnmC 5226143 mnmC Haemophilus influenzae PittEE 5-methylaminomethyl-2-thiouridine methyltransferase YP_001290813.1 1055527 D 374930 CDS YP_001290814.1 148826061 5226144 1057627..1058622 1 NC_009566.1 hypothetical protein 1058622 5226144 CGSHiEE_05255 Haemophilus influenzae PittEE hypothetical protein YP_001290814.1 1057627 D 374930 CDS YP_001290815.1 148826062 5226145 1058622..1059500 1 NC_009566.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; lic-1 operon protein 1059500 5226145 CGSHiEE_05260 Haemophilus influenzae PittEE lic-1 operon protein YP_001290815.1 1058622 D 374930 CDS YP_001290816.1 148826063 5226146 1059497..1060198 1 NC_009566.1 COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes; lic-1 operon protein 1060198 5226146 CGSHiEE_05265 Haemophilus influenzae PittEE lic-1 operon protein YP_001290816.1 1059497 D 374930 CDS YP_001290817.1 148826064 5225759 1063077..1063532 1 NC_009566.1 COG0778 Nitroreductase; hypothetical protein 1063532 5225759 CGSHiEE_05290 Haemophilus influenzae PittEE hypothetical protein YP_001290817.1 1063077 D 374930 CDS YP_001290818.1 148826065 5225760 complement(1063580..1064134) 1 NC_009566.1 COG3381 Uncharacterized component of anaerobic dehydrogenases; putative component of anaerobic dehydrogenase 1064134 5225760 CGSHiEE_05295 Haemophilus influenzae PittEE putative component of anaerobic dehydrogenase YP_001290818.1 1063580 R 374930 CDS YP_001290819.1 148826066 5225761 complement(1064127..1064741) 1 NC_009566.1 COG2249 Putative NADPH-quinone reductase (modulator of drug activity B); putative NAD(P)H oxidoreductase 1064741 5225761 CGSHiEE_05300 Haemophilus influenzae PittEE putative NAD(P)H oxidoreductase YP_001290819.1 1064127 R 374930 CDS YP_001290820.1 148826067 5225762 complement(1064862..1066106) 1 NC_009566.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 1066106 5225762 CGSHiEE_05305 Haemophilus influenzae PittEE serine/threonine transporter SstT YP_001290820.1 1064862 R 374930 CDS YP_001290821.1 148826068 5225763 1066389..1066829 1 NC_009566.1 COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases); 5-methylaminomethyl-2-thiouridine methyltransferase 1066829 mnmC 5225763 mnmC Haemophilus influenzae PittEE 5-methylaminomethyl-2-thiouridine methyltransferase YP_001290821.1 1066389 D 374930 CDS YP_001290822.1 148826069 5224698 complement(1066899..1067987) 1 NC_009566.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1067987 5224698 CGSHiEE_05315 Haemophilus influenzae PittEE phospho-2-dehydro-3-deoxyheptonate aldolase YP_001290822.1 1066899 R 374930 CDS YP_001290823.1 148826070 5224699 complement(1068206..1069456) 1 NC_009566.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1069456 5224699 CGSHiEE_05320 Haemophilus influenzae PittEE outer membrane-specific lipoprotein transporter subunit LolE YP_001290823.1 1068206 R 374930 CDS YP_001290824.1 148826071 5224700 complement(1069456..1070139) 1 NC_009566.1 COG1136 ABC-type antimicrobial peptide transport system, ATPase component; outer membrane-specific lipoprotein transporter subunit LolE 1070139 5224700 CGSHiEE_05325 Haemophilus influenzae PittEE outer membrane-specific lipoprotein transporter subunit LolE YP_001290824.1 1069456 R 374930 CDS YP_001290825.1 148826072 5224701 complement(1070221..1070862) 1 NC_009566.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 1070862 bioD 5224701 bioD Haemophilus influenzae PittEE dithiobiotin synthetase YP_001290825.1 1070221 R 374930 CDS YP_001290826.1 148826073 5224702 complement(1070872..1071654) 1 NC_009566.1 COG0500 SAM-dependent methyltransferases; biotin synthesis protein 1071654 5224702 CGSHiEE_05335 Haemophilus influenzae PittEE biotin synthesis protein YP_001290826.1 1070872 R 374930 CDS YP_001290827.1 148826074 5224703 complement(1071642..1072289) 1 NC_009566.1 COG2830 Uncharacterized protein conserved in bacteria; hypothetical protein 1072289 bioD 5224703 bioD Haemophilus influenzae PittEE hypothetical protein YP_001290827.1 1071642 R 374930 CDS YP_001290828.1 148826075 5225632 complement(1072299..1073441) 1 NC_009566.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 1073441 5225632 CGSHiEE_05345 Haemophilus influenzae PittEE 8-amino-7-oxononanoate synthase YP_001290828.1 1072299 R 374930 CDS YP_001290829.1 148826076 5225633 complement(1073450..1074739) 1 NC_009566.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine--8-amino-7-oxononanoate transaminase 1074739 5225633 CGSHiEE_05350 Haemophilus influenzae PittEE adenosylmethionine--8-amino-7-oxononanoate transaminase YP_001290829.1 1073450 R 374930 CDS YP_001290830.1 148826077 5225634 complement(1074761..1075942) 1 NC_009566.1 COG4591 ABC-type transport system, involved in lipoprotein release, permease component; adenosylmethionine--8-amino-7-oxononanoate transaminase 1075942 5225634 CGSHiEE_05355 Haemophilus influenzae PittEE adenosylmethionine--8-amino-7-oxononanoate transaminase YP_001290830.1 1074761 R 374930 CDS YP_001290831.1 148826078 5225635 complement(1075942..1076889) 1 NC_009566.1 Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor; glycerate dehydrogenase 1076889 5225635 CGSHiEE_05360 Haemophilus influenzae PittEE glycerate dehydrogenase YP_001290831.1 1075942 R 374930 CDS YP_001290832.1 148826079 5225636 complement(1076949..1077803) 1 NC_009566.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1077803 5225636 CGSHiEE_05365 Haemophilus influenzae PittEE 2-dehydro-3-deoxyphosphooctonate aldolase YP_001290832.1 1076949 R 374930 CDS YP_001290833.1 148826080 5225637 complement(1077818..1078621) 1 NC_009566.1 COG2912 Uncharacterized conserved protein; hypothetical protein 1078621 5225637 CGSHiEE_05370 Haemophilus influenzae PittEE hypothetical protein YP_001290833.1 1077818 R 374930 CDS YP_001290834.1 148826081 5225638 complement(1078621..1079499) 1 NC_009566.1 COG2890 Methylase of polypeptide chain release factors; hypothetical protein 1079499 5225638 CGSHiEE_05375 Haemophilus influenzae PittEE hypothetical protein YP_001290834.1 1078621 R 374930 CDS YP_001290835.1 148826082 5225691 complement(1079499..1079939) 1 NC_009566.1 COG1714 Predicted membrane protein/domain; hypothetical protein 1079939 5225691 CGSHiEE_05380 Haemophilus influenzae PittEE hypothetical protein YP_001290835.1 1079499 R 374930 CDS YP_001290836.1 148826083 5225692 complement(1079992..1081077) 1 NC_009566.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1081077 prfA 5225692 prfA Haemophilus influenzae PittEE peptide chain release factor 1 YP_001290836.1 1079992 R 374930 CDS YP_001290837.1 148826084 5225693 complement(1081184..1082236) 1 NC_009566.1 COG0790 FOG: TPR repeat, SEL1 subfamily; hypothetical protein 1082236 5225693 CGSHiEE_05390 Haemophilus influenzae PittEE hypothetical protein YP_001290837.1 1081184 R 374930 CDS YP_001290838.1 148826085 5225694 complement(1082236..1083000) 1 NC_009566.1 COG0790 FOG: TPR repeat, SEL1 subfamily; Sel1 repeat-containing protein 1083000 5225694 CGSHiEE_05395 Haemophilus influenzae PittEE Sel1 repeat-containing protein YP_001290838.1 1082236 R 374930 CDS YP_001290839.1 148826086 5225695 complement(1083013..1084224) 1 NC_009566.1 COG2333 Predicted hydrolase (metallo-beta-lactamase superfamily); hypothetical protein 1084224 5225695 CGSHiEE_05400 Haemophilus influenzae PittEE hypothetical protein YP_001290839.1 1083013 R 374930 CDS YP_001290840.1 148826087 5225696 complement(1084224..1085378) 1 NC_009566.1 COG0790 FOG: TPR repeat, SEL1 subfamily; Sel1 domain-containing protein 1085378 5225696 CGSHiEE_05405 Haemophilus influenzae PittEE Sel1 domain-containing protein YP_001290840.1 1084224 R 374930 CDS YP_001290841.1 148826088 5225704 complement(1085531..1086067) 1 NC_009566.1 COG3101 Uncharacterized protein conserved in bacteria; hypothetical protein 1086067 5225704 CGSHiEE_05410 Haemophilus influenzae PittEE hypothetical protein YP_001290841.1 1085531 R 374930 CDS YP_001290842.1 148826089 5225705 complement(1086458..1086592) 1 NC_009566.1 hypothetical protein 1086592 5225705 CGSHiEE_05415 Haemophilus influenzae PittEE hypothetical protein YP_001290842.1 1086458 R 374930 CDS YP_001290843.1 148826090 5225706 complement(1086811..1087002) 1 NC_009566.1 hypothetical protein 1087002 5225706 CGSHiEE_05420 Haemophilus influenzae PittEE hypothetical protein YP_001290843.1 1086811 R 374930 CDS YP_001290844.1 148826091 5225707 complement(1087153..1087821) 1 NC_009566.1 COG5005 Mu-like prophage protein gpG; hypothetical protein 1087821 5225707 CGSHiEE_05425 Haemophilus influenzae PittEE hypothetical protein YP_001290844.1 1087153 R 374930 CDS YP_001290845.1 148826092 5225708 complement(1087880..1088113) 1 NC_009566.1 hypothetical protein 1088113 5225708 CGSHiEE_05430 Haemophilus influenzae PittEE hypothetical protein YP_001290845.1 1087880 R 374930 CDS YP_001290846.1 148826093 5225709 1088113..1088643 1 NC_009566.1 COG4383 Mu-like prophage protein gp29; hypothetical protein 1088643 5225709 CGSHiEE_05435 Haemophilus influenzae PittEE hypothetical protein YP_001290846.1 1088113 D 374930 CDS YP_001290847.1 148826094 5225710 complement(1088751..1089041) 1 NC_009566.1 COG0582 Integrase; peptide chain release factor 1 1089041 prfA 5225710 prfA Haemophilus influenzae PittEE peptide chain release factor 1 YP_001290847.1 1088751 R 374930 CDS YP_001290848.1 148826095 5226001 1089578..1091014 1 NC_009566.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1091014 5226001 CGSHiEE_05445 Haemophilus influenzae PittEE pyruvate kinase YP_001290848.1 1089578 D 374930 CDS YP_001290849.1 148826096 5226002 1092572..1093654 1 NC_009566.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 1093654 alr 5226002 alr Haemophilus influenzae PittEE alanine racemase YP_001290849.1 1092572 D 374930 CDS YP_001290850.1 148826097 5226003 1093751..1095400 1 NC_009566.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 1095400 pgi 5226003 pgi Haemophilus influenzae PittEE glucose-6-phosphate isomerase YP_001290850.1 1093751 D 374930 CDS YP_001290851.1 148826098 5226004 1095635..1095733 1 NC_009566.1 hypothetical protein 1095733 5226004 CGSHiEE_05475 Haemophilus influenzae PittEE hypothetical protein YP_001290851.1 1095635 D 374930 CDS YP_001290852.1 148826099 5225858 1095735..1095971 1 NC_009566.1 COG0166 Glucose-6-phosphate isomerase; hypothetical protein 1095971 5225858 CGSHiEE_05480 Haemophilus influenzae PittEE hypothetical protein YP_001290852.1 1095735 D 374930 CDS YP_001290853.1 148826100 5225859 complement(1097206..1097670) 1 NC_009566.1 outer membrane lipoprotein PCP 1097670 5225859 CGSHiEE_05495 Haemophilus influenzae PittEE outer membrane lipoprotein PCP YP_001290853.1 1097206 R 374930 CDS YP_001290854.1 148826101 5225860 complement(1097693..1097989) 1 NC_009566.1 COG3133 Outer membrane lipoprotein; glucose-6-phosphate isomerase 1097989 pgi 5225860 pgi Haemophilus influenzae PittEE glucose-6-phosphate isomerase YP_001290854.1 1097693 R 374930 CDS YP_001290855.1 148826102 5225861 1098643..1100376 1 NC_009566.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1100376 argS 5225861 argS Haemophilus influenzae PittEE arginyl-tRNA synthetase YP_001290855.1 1098643 D 374930 CDS YP_001290856.1 148826103 5225862 complement(1100662..1101153) 1 NC_009566.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 1101153 ilvH 5225862 ilvH Haemophilus influenzae PittEE acetolactate synthase 3 regulatory subunit YP_001290856.1 1100662 R 374930 CDS YP_001290857.1 148826104 5225863 complement(1101153..1102874) 1 NC_009566.1 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 3 catalytic subunit 1102874 5225863 CGSHiEE_05525 Haemophilus influenzae PittEE acetolactate synthase 3 catalytic subunit YP_001290857.1 1101153 R 374930 CDS YP_001290858.1 148826105 5226293 complement(1102924..1103073) 1 NC_009566.1 COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; hypothetical protein 1103073 5226293 CGSHiEE_05530 Haemophilus influenzae PittEE hypothetical protein YP_001290858.1 1102924 R 374930 CDS YP_001290859.1 148826106 5226294 complement(1103141..1104661) 1 NC_009566.1 COG1757 Na+/H+ antiporter; Na+/H+ antiporter 1104661 5226294 CGSHiEE_05535 Haemophilus influenzae PittEE Na+/H+ antiporter YP_001290859.1 1103141 R 374930 CDS YP_001290860.1 148826107 5226295 1105104..1105472 1 NC_009566.1 COG2916 DNA-binding protein H-NS; acetolactate synthase 3 catalytic subunit 1105472 5226295 CGSHiEE_05540 Haemophilus influenzae PittEE acetolactate synthase 3 catalytic subunit YP_001290860.1 1105104 D 374930 CDS YP_001290861.1 148826108 5226296 1105577..1106413 1 NC_009566.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 1106413 purU 5226296 purU Haemophilus influenzae PittEE formyltetrahydrofolate deformylase YP_001290861.1 1105577 D 374930 CDS YP_001290862.1 148826109 5226297 1106413..1107711 1 NC_009566.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1107711 5226297 CGSHiEE_05550 Haemophilus influenzae PittEE 3-phosphoshikimate 1-carboxyvinyltransferase YP_001290862.1 1106413 D 374930 CDS YP_001290863.1 148826110 5226298 1109201..1110268 1 NC_009566.1 COG0438 Glycosyltransferase; hypothetical protein 1110268 5226298 CGSHiEE_05565 Haemophilus influenzae PittEE hypothetical protein YP_001290863.1 1109201 D 374930 CDS YP_001290864.1 148826111 5226170 complement(1110411..1111772) 1 NC_009566.1 COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase; recombination factor protein RarA 1111772 5226170 CGSHiEE_05570 Haemophilus influenzae PittEE recombination factor protein RarA YP_001290864.1 1110411 R 374930 CDS YP_001290865.1 148826112 5226171 complement(1111833..1112450) 1 NC_009566.1 participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 1112450 lolA 5226171 lolA Haemophilus influenzae PittEE outer-membrane lipoprotein carrier protein YP_001290865.1 1111833 R 374930 CDS YP_001290866.1 148826113 5226172 complement(1112468..1115236) 1 NC_009566.1 COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins; outer-membrane lipoprotein carrier protein 1115236 lolA 5226172 lolA Haemophilus influenzae PittEE outer-membrane lipoprotein carrier protein YP_001290866.1 1112468 R 374930 CDS YP_001290867.1 148826114 5226173 complement(1115238..1115717) 1 NC_009566.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 1115717 5226173 CGSHiEE_05585 Haemophilus influenzae PittEE leucine-responsive transcriptional regulator YP_001290867.1 1115238 R 374930 CDS YP_001290868.1 148826115 5226174 complement(1115797..1117173) 1 NC_009566.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 1117173 5226174 CGSHiEE_05590 Haemophilus influenzae PittEE DNA repair protein RadA YP_001290868.1 1115797 R 374930 CDS YP_001290869.1 148826116 5226175 complement(1117406..1118452) 1 NC_009566.1 COG3025 Uncharacterized conserved protein; hypothetical protein 1118452 5226175 CGSHiEE_05595 Haemophilus influenzae PittEE hypothetical protein YP_001290869.1 1117406 R 374930 CDS YP_001290870.1 148826117 5226305 1118977..1123743 1 NC_009566.1 COG3210 Large exoproteins involved in heme utilization or adhesion; HMW2A, high molecular weight adhesin 2 1123743 5226305 CGSHiEE_05600 Haemophilus influenzae PittEE HMW2A, high molecular weight adhesin 2 YP_001290870.1 1118977 D 374930 CDS YP_001290871.1 148826118 5226306 1123895..1125532 1 NC_009566.1 COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component; HMW1B, OMP-85-like protein required for secretion of HMW1A and HMW2A 1125532 5226306 CGSHiEE_05605 Haemophilus influenzae PittEE HMW1B, OMP-85-like protein required for secretion of HMW1A and HMW2A YP_001290871.1 1123895 D 374930 CDS YP_001290872.1 148826119 5226307 1125747..1127699 1 NC_009566.1 COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family; HMW1C, putative glycosyltransferase involved in glycosylation of HMW1A and HMW2A 1127699 5226307 CGSHiEE_05610 Haemophilus influenzae PittEE HMW1C, putative glycosyltransferase involved in glycosylation of HMW1A and HMW2A YP_001290872.1 1125747 D 374930 CDS YP_001290873.1 148826120 5226308 1127888..1128052 1 NC_009566.1 hypothetical protein 1128052 5226308 CGSHiEE_05615 Haemophilus influenzae PittEE hypothetical protein YP_001290873.1 1127888 D 374930 CDS YP_001290874.1 148826121 5226309 complement(1128502..1128618) 1 NC_009566.1 COG0675 Transposase and inactivated derivatives; hypothetical protein 1128618 5226309 CGSHiEE_05620 Haemophilus influenzae PittEE hypothetical protein YP_001290874.1 1128502 R 374930 CDS YP_001290875.1 148826122 5226310 complement(1129017..1129181) 1 NC_009566.1 COG2801 Transposase and inactivated derivatives; hypothetical protein 1129181 5226310 CGSHiEE_05625 Haemophilus influenzae PittEE hypothetical protein YP_001290875.1 1129017 R 374930 CDS YP_001290876.1 148826123 5226311 complement(1129311..1129649) 1 NC_009566.1 putative ABC-type chelated iron transport system, permease 1129649 5226311 CGSHiEE_05630 Haemophilus influenzae PittEE putative ABC-type chelated iron transport system, permease YP_001290876.1 1129311 R 374930 CDS YP_001290877.1 148826124 5225789 1129717..1129905 1 NC_009566.1 COG5566 Uncharacterized conserved protein; hypothetical protein 1129905 5225789 CGSHiEE_05635 Haemophilus influenzae PittEE hypothetical protein YP_001290877.1 1129717 D 374930 CDS YP_001290878.1 148826125 5225790 complement(1130292..1131008) 1 NC_009566.1 COG3219 Uncharacterized protein conserved in bacteria; hypothetical protein 1131008 5225790 CGSHiEE_05640 Haemophilus influenzae PittEE hypothetical protein YP_001290878.1 1130292 R 374930 CDS YP_001290879.1 148826126 5225791 complement(1130998..1131921) 1 NC_009566.1 COG3220 Uncharacterized protein conserved in bacteria; hypothetical protein 1131921 5225791 CGSHiEE_05645 Haemophilus influenzae PittEE hypothetical protein YP_001290879.1 1130998 R 374930 CDS YP_001290880.1 148826127 5225792 complement(1131982..1132269) 1 NC_009566.1 COG3767 Uncharacterized low-complexity protein; hypothetical protein 1132269 5225792 CGSHiEE_05650 Haemophilus influenzae PittEE hypothetical protein YP_001290880.1 1131982 R 374930 CDS YP_001290881.1 148826128 5225793 1132973..1133653 1 NC_009566.1 COG1392 Phosphate transport regulator (distant homolog of PhoU); phosphate transport regulator 1133653 5225793 CGSHiEE_05665 Haemophilus influenzae PittEE phosphate transport regulator YP_001290881.1 1132973 D 374930 CDS YP_001290882.1 148826129 5225794 1133678..1134940 1 NC_009566.1 COG0306 Phosphate/sulphate permeases; putative phosphate permease 1134940 5225794 CGSHiEE_05670 Haemophilus influenzae PittEE putative phosphate permease YP_001290882.1 1133678 D 374930 CDS YP_001290883.1 148826130 5226214 1135006..1135617 1 NC_009566.1 COG3103 SH3 domain protein; hypothetical protein 1135617 5226214 CGSHiEE_05675 Haemophilus influenzae PittEE hypothetical protein YP_001290883.1 1135006 D 374930 CDS YP_001290884.1 148826131 5226215 1135624..1136874 1 NC_009566.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 1136874 cca 5226215 cca Haemophilus influenzae PittEE multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase YP_001290884.1 1135624 D 374930 CDS YP_001290885.1 148826132 5226216 1136946..1137566 1 NC_009566.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB 1137566 lolB 5226216 lolB Haemophilus influenzae PittEE outer membrane lipoprotein LolB YP_001290885.1 1136946 D 374930 CDS YP_001290886.1 148826133 5226217 1137566..1138519 1 NC_009566.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1138519 ipk 5226217 ipk Haemophilus influenzae PittEE 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_001290886.1 1137566 D 374930 CDS YP_001290887.1 148826134 5226218 1138521..1139468 1 NC_009566.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1139468 5226218 CGSHiEE_05695 Haemophilus influenzae PittEE ribose-phosphate pyrophosphokinase YP_001290887.1 1138521 D 374930 CDS YP_001290888.1 148826135 5226219 complement(1140923..1141639) 1 NC_009566.1 Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A 1141639 5226219 CGSHiEE_05710 Haemophilus influenzae PittEE sugar fermentation stimulation protein A YP_001290888.1 1140923 R 374930 CDS YP_001290889.1 148826136 5226208 complement(1141648..1143042) 1 NC_009566.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1143042 5226208 CGSHiEE_05715 Haemophilus influenzae PittEE multidrug efflux protein YP_001290889.1 1141648 R 374930 CDS YP_001290890.1 148826137 5226209 1143086..1143700 1 NC_009566.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1143700 5226209 CGSHiEE_05720 Haemophilus influenzae PittEE riboflavin synthase subunit alpha YP_001290890.1 1143086 D 374930 CDS YP_001290891.1 148826138 5226210 complement(1143772..1146381) 1 NC_009566.1 COG0308 Aminopeptidase N; aminopeptidase N 1146381 pepN 5226210 pepN Haemophilus influenzae PittEE aminopeptidase N YP_001290891.1 1143772 R 374930 CDS YP_001290892.1 148826139 5226211 complement(1146425..1146769) 1 NC_009566.1 hypothetical protein 1146769 5226211 CGSHiEE_05730 Haemophilus influenzae PittEE hypothetical protein YP_001290892.1 1146425 R 374930 CDS YP_001290893.1 148826140 5226212 complement(1146766..1147014) 1 NC_009566.1 COG0024 Methionine aminopeptidase; hypothetical protein 1147014 5226212 CGSHiEE_05735 Haemophilus influenzae PittEE hypothetical protein YP_001290893.1 1146766 R 374930 CDS YP_001290894.1 148826141 5226213 1147185..1147679 1 NC_009566.1 COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; riboflavin synthase subunit alpha 1147679 5226213 CGSHiEE_05740 Haemophilus influenzae PittEE riboflavin synthase subunit alpha YP_001290894.1 1147185 D 374930 CDS YP_001290895.1 148826142 5225395 1147749..1148837 1 NC_009566.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 1148837 5225395 CGSHiEE_05745 Haemophilus influenzae PittEE phosphoribosylaminoimidazole carboxylase ATPase subunit YP_001290895.1 1147749 D 374930 CDS YP_001290896.1 148826143 5225396 1148976..1150166 1 NC_009566.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 1150166 5225396 CGSHiEE_05750 Haemophilus influenzae PittEE aromatic amino acid aminotransferase YP_001290896.1 1148976 D 374930 CDS YP_001290897.1 148826144 5225397 complement(1150273..1150899) 1 NC_009566.1 COG1122 ABC-type cobalt transport system, ATPase component; cobalt ABC transporter ATPase 1150899 5225397 CGSHiEE_05755 Haemophilus influenzae PittEE cobalt ABC transporter ATPase YP_001290897.1 1150273 R 374930 CDS YP_001290898.1 148826145 5225398 complement(1150901..1151533) 1 NC_009566.1 COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters; aromatic-amino-acid aminotransferase 1151533 5225398 CGSHiEE_05760 Haemophilus influenzae PittEE aromatic-amino-acid aminotransferase YP_001290898.1 1150901 R 374930 CDS YP_001290899.1 148826146 5225399 complement(1151533..1152153) 1 NC_009566.1 catalyzes the ATP-dependent transport of cobalt; cobalt transport protein CbiM 1152153 5225399 CGSHiEE_05765 Haemophilus influenzae PittEE cobalt transport protein CbiM YP_001290899.1 1151533 R 374930 CDS YP_001290900.1 148826147 5225400 complement(1152153..1152641) 1 NC_009566.1 COG0013 Alanyl-tRNA synthetase; hypothetical protein 1152641 5225400 CGSHiEE_05770 Haemophilus influenzae PittEE hypothetical protein YP_001290900.1 1152153 R 374930 CDS YP_001290901.1 148826148 5225401 complement(1152654..1153337) 1 NC_009566.1 COG5266 ABC-type Co2+ transport system, periplasmic component; putative ABC-type Co2+ transport system, periplasmic component 1153337 5225401 CGSHiEE_05775 Haemophilus influenzae PittEE putative ABC-type Co2+ transport system, periplasmic component YP_001290901.1 1152654 R 374930 CDS YP_001290902.1 148826149 5225548 1153427..1153834 1 NC_009566.1 COG0789 Predicted transcriptional regulators; HTH-type transcriptional regulator 1153834 5225548 CGSHiEE_05780 Haemophilus influenzae PittEE HTH-type transcriptional regulator YP_001290902.1 1153427 D 374930 CDS YP_001290903.1 148826150 5225549 complement(1153849..1154391) 1 NC_009566.1 COG0790 FOG: TPR repeat, SEL1 subfamily; hypothetical protein 1154391 5225549 CGSHiEE_05785 Haemophilus influenzae PittEE hypothetical protein YP_001290903.1 1153849 R 374930 CDS YP_001290904.1 148826151 5225550 1155219..1155569 1 NC_009566.1 COG0251 Putative translation initiation inhibitor, yjgF family; putative translation initiation inhibitor, YjgF family protein 1155569 5225550 CGSHiEE_05800 Haemophilus influenzae PittEE putative translation initiation inhibitor, YjgF family protein YP_001290904.1 1155219 D 374930 CDS YP_001290905.1 148826152 5225551 1155600..1156016 1 NC_009566.1 COG3105 Uncharacterized protein conserved in bacteria; hypothetical protein 1156016 5225551 CGSHiEE_05805 Haemophilus influenzae PittEE hypothetical protein YP_001290905.1 1155600 D 374930 CDS YP_001290906.1 148826153 5225552 complement(1156063..1156668) 1 NC_009566.1 COG0586 Uncharacterized membrane-associated protein; cobalt transport protein CbiM 1156668 5225552 CGSHiEE_05810 Haemophilus influenzae PittEE cobalt transport protein CbiM YP_001290906.1 1156063 R 374930 CDS YP_001290907.1 148826154 5225553 1156887..1157174 1 NC_009566.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 1157174 5225553 CGSHiEE_05815 Haemophilus influenzae PittEE 50S ribosomal protein L25 YP_001290907.1 1156887 D 374930 CDS YP_001290909.1 148826156 5226030 1158021..1158386 1 NC_009566.1 COG0527 Aspartokinases; 50S ribosomal protein L25 1158386 5226030 CGSHiEE_05825 Haemophilus influenzae PittEE 50S ribosomal protein L25 YP_001290909.1 1158021 D 374930 CDS YP_001290910.1 148826157 5226031 1158515..1159813 1 NC_009566.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 1159813 5226031 CGSHiEE_05830 Haemophilus influenzae PittEE adenylosuccinate synthetase YP_001290910.1 1158515 D 374930 CDS YP_001290911.1 148826158 5226032 complement(1159873..1160700) 1 NC_009566.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 1160700 dapD 5226032 dapD Haemophilus influenzae PittEE 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase YP_001290911.1 1159873 R 374930 CDS YP_001290913.1 148826160 5226034 1161063..1162073 1 NC_009566.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 1162073 dapD 5226034 dapD Haemophilus influenzae PittEE DNA-binding transcriptional repressor PurR YP_001290913.1 1161063 D 374930 CDS YP_001290914.1 148826161 5226035 1162256..1164895 1 NC_009566.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 1164895 5226035 CGSHiEE_05850 Haemophilus influenzae PittEE phosphoenolpyruvate carboxylase YP_001290914.1 1162256 D 374930 CDS YP_001290915.1 148826162 5226057 complement(1165040..1165168) 1 NC_009566.1 COG2801 Transposase and inactivated derivatives; transposase 1165168 5226057 CGSHiEE_05855 Haemophilus influenzae PittEE transposase YP_001290915.1 1165040 R 374930 CDS YP_001290916.1 148826163 5226058 complement(1165169..1165288) 1 NC_009566.1 COG2801 Transposase and inactivated derivatives; transposase 1165288 5226058 CGSHiEE_05860 Haemophilus influenzae PittEE transposase YP_001290916.1 1165169 R 374930 CDS YP_001290917.1 148826164 5226059 1165748..1166977 1 NC_009566.1 COG0270 Site-specific DNA methylase; modification methylase 1166977 5226059 CGSHiEE_05865 Haemophilus influenzae PittEE modification methylase YP_001290917.1 1165748 D 374930 CDS YP_001290918.1 148826165 5226060 1166980..1167963 1 NC_009566.1 COG3440 Predicted restriction endonuclease; putative type II restriction endonuclease 1167963 5226060 CGSHiEE_05870 Haemophilus influenzae PittEE putative type II restriction endonuclease YP_001290918.1 1166980 D 374930 CDS YP_001290919.1 148826166 5226061 complement(1168007..1169419) 1 NC_009566.1 COG3106 Predicted ATPase; hypothetical protein 1169419 5226061 CGSHiEE_05875 Haemophilus influenzae PittEE hypothetical protein YP_001290919.1 1168007 R 374930 CDS YP_001290920.1 148826167 5226062 1169489..1171183 1 NC_009566.1 COG4166 ABC-type oligopeptide transport system, periplasmic component; anti peptide resistance ABC transporter periplasmic protein 1171183 5226062 CGSHiEE_05880 Haemophilus influenzae PittEE anti peptide resistance ABC transporter periplasmic protein YP_001290920.1 1169489 D 374930 CDS YP_001290921.1 148826168 5226063 1171183..1172148 1 NC_009566.1 COG4168 ABC-type antimicrobial peptide transport system, permease component; peptide ABC transporter permease protein 1172148 5226063 CGSHiEE_05885 Haemophilus influenzae PittEE peptide ABC transporter permease protein YP_001290921.1 1171183 D 374930 CDS YP_001290922.1 148826169 5225639 1173030..1174079 1 NC_009566.1 COG4170 ABC-type antimicrobial peptide transport system, ATPase component; peptide ABC transporter ATP-binding protein 1174079 5225639 CGSHiEE_05900 Haemophilus influenzae PittEE peptide ABC transporter ATP-binding protein YP_001290922.1 1173030 D 374930 CDS YP_001290923.1 148826170 5225640 1174079..1174888 1 NC_009566.1 COG4167 ABC-type antimicrobial peptide transport system, ATPase component; anti peptide resistance ABC transporter ATPase 1174888 5225640 CGSHiEE_05905 Haemophilus influenzae PittEE anti peptide resistance ABC transporter ATPase YP_001290923.1 1174079 D 374930 CDS YP_001290924.1 148826171 5225641 1174900..1175916 1 NC_009566.1 COG2855 Predicted membrane protein; phosphoenolpyruvate carboxylase 1175916 5225641 CGSHiEE_05910 Haemophilus influenzae PittEE phosphoenolpyruvate carboxylase YP_001290924.1 1174900 D 374930 CDS YP_001290925.1 148826172 5225642 1177055..1178056 1 NC_009566.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 1178056 5225642 CGSHiEE_05925 Haemophilus influenzae PittEE fructose-1,6-bisphosphatase YP_001290925.1 1177055 D 374930 CDS YP_001290926.1 148826173 5225643 complement(1178091..1178186) 1 NC_009566.1 COG0158 Fructose-1,6-bisphosphatase; cytidylate kinase 1178186 5225643 CGSHiEE_05930 Haemophilus influenzae PittEE cytidylate kinase YP_001290926.1 1178091 R 374930 CDS YP_001290927.1 148826174 5225900 1178460..1180058 1 NC_009566.1 COG1620 L-lactate permease; putative L-lactate permease 1180058 5225900 CGSHiEE_05935 Haemophilus influenzae PittEE putative L-lactate permease YP_001290927.1 1178460 D 374930 CDS YP_001290928.1 148826175 5225901 complement(1183191..1183880) 1 NC_009566.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1183880 5225901 CGSHiEE_05950 Haemophilus influenzae PittEE 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_001290928.1 1183191 R 374930 CDS YP_001290929.1 148826176 5225902 complement(1183877..1184572) 1 NC_009566.1 COG0526 Thiol-disulfide isomerase and thioredoxins; hypothetical protein 1184572 5225902 CGSHiEE_05955 Haemophilus influenzae PittEE hypothetical protein YP_001290929.1 1183877 R 374930 CDS YP_001290930.1 148826177 5225903 complement(1184577..1184762) 1 NC_009566.1 COG0608 Single-stranded DNA-specific exonuclease; single-stranded-DNA-specific exonuclease RecJ 1184762 5225903 CGSHiEE_05960 Haemophilus influenzae PittEE single-stranded-DNA-specific exonuclease RecJ YP_001290930.1 1184577 R 374930 CDS YP_001290931.1 148826178 5225904 complement(1184710..1186305) 1 NC_009566.1 COG0608 Single-stranded DNA-specific exonuclease; single-stranded-DNA-specific exonuclease RecJ 1186305 5225904 CGSHiEE_05965 Haemophilus influenzae PittEE single-stranded-DNA-specific exonuclease RecJ YP_001290931.1 1184710 R 374930 CDS YP_001290932.1 148826179 5225905 complement(1186590..1187279) 1 NC_009566.1 COG1651 Protein-disulfide isomerase; thiol-disulfide interchange protein 1187279 5225905 CGSHiEE_05970 Haemophilus influenzae PittEE thiol-disulfide interchange protein YP_001290932.1 1186590 R 374930 CDS YP_001290933.1 148826180 5225777 1187764..1188510 1 NC_009566.1 COG1186 Protein chain release factor B; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1188510 5225777 CGSHiEE_05975 Haemophilus influenzae PittEE 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_001290933.1 1187764 D 374930 CDS YP_001290934.1 148826181 5225778 1188623..1190131 1 NC_009566.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 1190131 lysS 5225778 lysS Haemophilus influenzae PittEE lysyl-tRNA synthetase YP_001290934.1 1188623 D 374930 CDS YP_001290935.1 148826182 5225779 complement(1190217..1191152) 1 NC_009566.1 oxidizes malate to oxaloacetate; malate dehydrogenase 1191152 5225779 CGSHiEE_05985 Haemophilus influenzae PittEE malate dehydrogenase YP_001290935.1 1190217 R 374930 CDS YP_001290936.1 148826183 5225780 1191359..1191814 1 NC_009566.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 1191814 5225780 CGSHiEE_05990 Haemophilus influenzae PittEE arginine repressor YP_001290936.1 1191359 D 374930 CDS YP_001290937.1 148826184 5225781 1191814..1192704 1 NC_009566.1 COG1090 Predicted nucleoside-diphosphate sugar epimerase; arginine repressor 1192704 5225781 CGSHiEE_05995 Haemophilus influenzae PittEE arginine repressor YP_001290937.1 1191814 D 374930 CDS YP_001290938.1 148826185 5225782 complement(1192761..1194278) 1 NC_009566.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 1194278 5225782 CGSHiEE_06000 Haemophilus influenzae PittEE amidophosphoribosyltransferase YP_001290938.1 1192761 R 374930 CDS YP_001290939.1 148826186 5225783 complement(1194868..1195311) 1 NC_009566.1 COG3092 Uncharacterized protein conserved in bacteria; hypothetical protein 1195311 5225783 CGSHiEE_06015 Haemophilus influenzae PittEE hypothetical protein YP_001290939.1 1194868 R 374930 CDS YP_001290940.1 148826187 5226154 1195529..1196734 1 NC_009566.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 1196734 5226154 CGSHiEE_06020 Haemophilus influenzae PittEE acetate kinase YP_001290940.1 1195529 D 374930 CDS YP_001290941.1 148826188 5226155 1196802..1198937 1 NC_009566.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 1198937 5226155 CGSHiEE_06025 Haemophilus influenzae PittEE phosphate acetyltransferase YP_001290941.1 1196802 D 374930 CDS YP_001290942.1 148826189 5226156 complement(1199015..1199518) 1 NC_009566.1 COG2840 Uncharacterized protein conserved in bacteria; hypothetical protein 1199518 5226156 CGSHiEE_06030 Haemophilus influenzae PittEE hypothetical protein YP_001290942.1 1199015 R 374930 CDS YP_001290943.1 148826190 5226157 1199648..1200592 1 NC_009566.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1200592 5226157 CGSHiEE_06035 Haemophilus influenzae PittEE N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_001290943.1 1199648 D 374930 CDS YP_001290944.1 148826191 5226158 complement(1200651..1201622) 1 NC_009566.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1201622 cysB 5226158 cysB Haemophilus influenzae PittEE transcriptional regulator CysB YP_001290944.1 1200651 R 374930 CDS YP_001290945.1 148826192 5226159 complement(1201633..1202706) 1 NC_009566.1 COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; ribosomal large subunit pseudouridine synthase B 1202706 5226159 CGSHiEE_06045 Haemophilus influenzae PittEE ribosomal large subunit pseudouridine synthase B YP_001290945.1 1201633 R 374930 CDS YP_001290946.1 148826193 5224662 complement(1202754..1203377) 1 NC_009566.1 COG0009 Putative translation factor (SUA5); hypothetical protein 1203377 5224662 CGSHiEE_06050 Haemophilus influenzae PittEE hypothetical protein YP_001290946.1 1202754 R 374930 CDS YP_001290947.1 148826194 5224663 complement(1203498..1204379) 1 NC_009566.1 COG0074 Succinyl-CoA synthetase, alpha subunit; succinyl-CoA synthetase subunit alpha 1204379 5224663 CGSHiEE_06055 Haemophilus influenzae PittEE succinyl-CoA synthetase subunit alpha YP_001290947.1 1203498 R 374930 CDS YP_001290948.1 148826195 5224664 complement(1204379..1205548) 1 NC_009566.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 1205548 cysB 5224664 cysB Haemophilus influenzae PittEE succinyl-CoA synthetase subunit beta YP_001290948.1 1204379 R 374930 CDS YP_001290949.1 148826196 5224665 complement(1205584..1206675) 1 NC_009566.1 COG2933 Predicted SAM-dependent methyltransferase; putative RNA 2'-O-ribose methyltransferase 1206675 5224665 CGSHiEE_06065 Haemophilus influenzae PittEE putative RNA 2'-O-ribose methyltransferase YP_001290949.1 1205584 R 374930 CDS YP_001290950.1 148826197 5224666 complement(1206668..1207561) 1 NC_009566.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA 1207561 5224666 CGSHiEE_06070 Haemophilus influenzae PittEE DNA-binding transcriptional activator GcvA YP_001290950.1 1206668 R 374930 CDS YP_001290951.1 148826198 5224667 1208037..1209068 1 NC_009566.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 1209068 5224667 CGSHiEE_06075 Haemophilus influenzae PittEE branched-chain amino acid aminotransferase YP_001290951.1 1208037 D 374930 CDS YP_001290952.1 148826199 5224668 complement(1209119..1209262) 1 NC_009566.1 COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; hypothetical protein 1209262 5224668 CGSHiEE_06080 Haemophilus influenzae PittEE hypothetical protein YP_001290952.1 1209119 R 374930 CDS YP_001290953.1 148826200 5225685 1209419..1210102 1 NC_009566.1 COG0603 Predicted PP-loop superfamily ATPase; PP-loop superfamily ATPase 1210102 5225685 CGSHiEE_06085 Haemophilus influenzae PittEE PP-loop superfamily ATPase YP_001290953.1 1209419 D 374930 CDS YP_001290954.1 148826201 5225686 1210095..1210520 1 NC_009566.1 COG0720 6-pyruvoyl-tetrahydropterin synthase; 6-pyruvoyl tetrahydrobiopterin synthase 1210520 5225686 CGSHiEE_06090 Haemophilus influenzae PittEE 6-pyruvoyl tetrahydrobiopterin synthase YP_001290954.1 1210095 D 374930 CDS YP_001290955.1 148826202 5225687 1210521..1211156 1 NC_009566.1 COG0602 Organic radical activating enzymes; organic radical activating protein 1211156 5225687 CGSHiEE_06095 Haemophilus influenzae PittEE organic radical activating protein YP_001290955.1 1210521 D 374930 CDS YP_001290956.1 148826203 5225688 1211402..1211788 1 NC_009566.1 COG0327 Uncharacterized conserved protein; branched-chain amino acid aminotransferase 1211788 5225688 CGSHiEE_06100 Haemophilus influenzae PittEE branched-chain amino acid aminotransferase YP_001290956.1 1211402 D 374930 CDS YP_001290957.1 148826204 5225689 1211775..1213955 1 NC_009566.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 1213955 uvrD 5225689 uvrD Haemophilus influenzae PittEE DNA-dependent helicase II YP_001290957.1 1211775 D 374930 CDS YP_001290958.1 148826205 5225690 1215062..1215949 1 NC_009566.1 COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; DNA-dependent helicase II 1215949 uvrD 5225690 uvrD Haemophilus influenzae PittEE DNA-dependent helicase II YP_001290958.1 1215062 D 374930 CDS YP_001290959.1 148826206 5226321 1215959..1216951 1 NC_009566.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit 1216951 dppD 5226321 dppD Haemophilus influenzae PittEE dipeptide transporter ATP-binding subunit YP_001290959.1 1215959 D 374930 CDS YP_001290960.1 148826207 5226322 1216954..1217937 1 NC_009566.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit 1217937 dppF 5226322 dppF Haemophilus influenzae PittEE dipeptide transporter ATP-binding subunit YP_001290960.1 1216954 D 374930 CDS YP_001290961.1 148826208 5226323 complement(1217966..1218661) 1 NC_009566.1 catalyzes the formation of a phosphodiester at the site of a single-strand break in duplex DNA; DNA ligase 1218661 5226323 CGSHiEE_06135 Haemophilus influenzae PittEE DNA ligase YP_001290961.1 1217966 R 374930 CDS YP_001290962.1 148826209 5226324 1218979..1219563 1 NC_009566.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 1219563 gmhA 5226324 gmhA Haemophilus influenzae PittEE phosphoheptose isomerase YP_001290962.1 1218979 D 374930 CDS YP_001290963.1 148826210 5226325 1219689..1220420 1 NC_009566.1 With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit 1220420 artP 5226325 artP Haemophilus influenzae PittEE arginine transporter ATP-binding subunit YP_001290963.1 1219689 D 374930 CDS YP_001290964.1 148826211 5226326 1220438..1221157 1 NC_009566.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; arginine transporter ATP-binding protein 1221157 artP 5226326 artP Haemophilus influenzae PittEE arginine transporter ATP-binding protein YP_001290964.1 1220438 D 374930 CDS YP_001290965.1 148826212 5226327 1221161..1221826 1 NC_009566.1 with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ 1221826 5226327 CGSHiEE_06155 Haemophilus influenzae PittEE arginine transporter permease subunit ArtQ YP_001290965.1 1221161 D 374930 CDS YP_001290966.1 148826213 5225625 1221826..1222509 1 NC_009566.1 with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM 1222509 artM 5225625 artM Haemophilus influenzae PittEE arginine transporter permease subunit ArtM YP_001290966.1 1221826 D 374930 CDS YP_001290967.1 148826214 5225626 1222715..1223026 1 NC_009566.1 COG5295 Autotransporter adhesin; hypothetical protein 1223026 5225626 CGSHiEE_06165 Haemophilus influenzae PittEE hypothetical protein YP_001290967.1 1222715 D 374930 CDS YP_001290968.1 148826215 5225627 complement(1223124..1223636) 1 NC_009566.1 COG3637 Opacity protein and related surface antigens; opacity protein 1223636 artM 5225627 artM Haemophilus influenzae PittEE opacity protein YP_001290968.1 1223124 R 374930 CDS YP_001290969.1 148826216 5225628 complement(1223766..1224203) 1 NC_009566.1 COG3091 Uncharacterized protein conserved in bacteria; hypothetical protein 1224203 5225628 CGSHiEE_06175 Haemophilus influenzae PittEE hypothetical protein YP_001290969.1 1223766 R 374930 CDS YP_001290970.1 148826217 5225629 complement(1224493..1225647) 1 NC_009566.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1225647 5225629 CGSHiEE_06180 Haemophilus influenzae PittEE S-adenosylmethionine synthetase YP_001290970.1 1224493 R 374930 CDS YP_001290971.1 148826218 5225630 complement(1225732..1226313) 1 NC_009566.1 catalyzes the formation of anthranilate from chorismate and glutamine; functions in tryptophan biosynthesis; putative anthranilate synthase component II 1226313 5225630 CGSHiEE_06185 Haemophilus influenzae PittEE putative anthranilate synthase component II YP_001290971.1 1225732 R 374930 CDS YP_001290972.1 148826219 5225631 1226355..1227341 1 NC_009566.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; para-aminobenzoate synthase component I 1227341 5225631 CGSHiEE_06190 Haemophilus influenzae PittEE para-aminobenzoate synthase component I YP_001290972.1 1226355 D 374930 CDS YP_001290973.1 148826220 5225914 1227341..1227907 1 NC_009566.1 COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; hypothetical protein 1227907 5225914 CGSHiEE_06195 Haemophilus influenzae PittEE hypothetical protein YP_001290973.1 1227341 D 374930 CDS YP_001290974.1 148826221 5225915 complement(1227947..1228291) 1 NC_009566.1 COG2926 Uncharacterized protein conserved in bacteria; hypothetical protein 1228291 5225915 CGSHiEE_06200 Haemophilus influenzae PittEE hypothetical protein YP_001290974.1 1227947 R 374930 CDS YP_001290975.1 148826222 5225916 1228483..1229571 1 NC_009566.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 1229571 5225916 CGSHiEE_06205 Haemophilus influenzae PittEE phosphoserine aminotransferase YP_001290975.1 1228483 D 374930 CDS YP_001290976.1 148826223 5225917 complement(1230836..1231159) 1 NC_009566.1 COG0278 Glutaredoxin-related protein; glutaredoxin-like protein 1231159 5225917 CGSHiEE_06220 Haemophilus influenzae PittEE glutaredoxin-like protein YP_001290976.1 1230836 R 374930 CDS YP_001290977.1 148826224 5225918 complement(1231310..1232026) 1 NC_009566.1 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; outer membrane protein P5 1232026 5225918 CGSHiEE_06225 Haemophilus influenzae PittEE outer membrane protein P5 YP_001290977.1 1231310 R 374930 CDS YP_001290978.1 148826225 5225919 1232778..1235861 1 NC_009566.1 COG0277 FAD/FMN-containing dehydrogenases; hypothetical protein 1235861 5225919 CGSHiEE_06230 Haemophilus influenzae PittEE hypothetical protein YP_001290978.1 1232778 D 374930 CDS YP_001290979.1 148826226 5224710 1235875..1236291 1 NC_009566.1 COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; hypothetical protein 1236291 5224710 CGSHiEE_06235 Haemophilus influenzae PittEE hypothetical protein YP_001290979.1 1235875 D 374930 CDS YP_001290980.1 148826227 5224711 1236288..1237259 1 NC_009566.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 1237259 hemH 5224711 hemH Haemophilus influenzae PittEE ferrochelatase YP_001290980.1 1236288 D 374930 CDS YP_001290981.1 148826228 5224712 1237339..1238196 1 NC_009566.1 COG3118 Thioredoxin domain-containing protein; thioredoxin domain-containing protein 1238196 5224712 CGSHiEE_06245 Haemophilus influenzae PittEE thioredoxin domain-containing protein YP_001290981.1 1237339 D 374930 CDS YP_001290982.1 148826229 5224713 1238270..1239226 1 NC_009566.1 COG0492 Thioredoxin reductase; ferrochelatase 1239226 hemH 5224713 hemH Haemophilus influenzae PittEE ferrochelatase YP_001290982.1 1238270 D 374930 CDS YP_001290983.1 148826230 5224714 1239298..1241058 1 NC_009566.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component 1241058 5224714 CGSHiEE_06255 Haemophilus influenzae PittEE cysteine/glutathione ABC transporter membrane/ATP-binding component YP_001290983.1 1239298 D 374930 CDS YP_001290984.1 148826231 5224715 1241058..1242788 1 NC_009566.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component 1242788 5224715 CGSHiEE_06260 Haemophilus influenzae PittEE cysteine/glutathione ABC transporter membrane/ATP-binding component YP_001290984.1 1241058 D 374930 CDS YP_001290985.1 148826232 5224716 1243037..1243504 1 NC_009566.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein 1243504 nrdG 5224716 nrdG Haemophilus influenzae PittEE anaerobic ribonucleotide reductase-activating protein YP_001290985.1 1243037 D 374930 CDS YP_001290986.1 148826233 5226133 complement(1243603..1244925) 1 NC_009566.1 COG1823 Predicted Na+/dicarboxylate symporter; proton glutamate symport protein 1244925 5226133 CGSHiEE_06270 Haemophilus influenzae PittEE proton glutamate symport protein YP_001290986.1 1243603 R 374930 CDS YP_001290987.1 148826234 5226134 complement(1245020..1245229) 1 NC_009566.1 COG1280 Putative threonine efflux protein; hypothetical protein 1245229 5226134 CGSHiEE_06275 Haemophilus influenzae PittEE hypothetical protein YP_001290987.1 1245020 R 374930 CDS YP_001290988.1 148826235 5226135 complement(1245231..1245770) 1 NC_009566.1 COG0634 Hypoxanthine-guanine phosphoribosyltransferase; hypoxanthine-guanine phosphoribosyltransferase 1245770 5226135 CGSHiEE_06280 Haemophilus influenzae PittEE hypoxanthine-guanine phosphoribosyltransferase YP_001290988.1 1245231 R 374930 CDS YP_001290989.1 148826236 5226136 complement(1245980..1247335) 1 NC_009566.1 COG0312 Predicted Zn-dependent proteases and their inactivated homologs; anaerobic ribonucleotide reductase-activating protein 1247335 nrdG 5226136 nrdG Haemophilus influenzae PittEE anaerobic ribonucleotide reductase-activating protein YP_001290989.1 1245980 R 374930 CDS YP_001290990.1 148826237 5226137 1247424..1247960 1 NC_009566.1 COG3028 Uncharacterized protein conserved in bacteria; hypothetical protein 1247960 5226137 CGSHiEE_06290 Haemophilus influenzae PittEE hypothetical protein YP_001290990.1 1247424 D 374930 CDS YP_001290991.1 148826238 5226138 1248011..1248625 1 NC_009566.1 COG3117 Uncharacterized protein conserved in bacteria; hypothetical protein 1248625 5226138 CGSHiEE_06295 Haemophilus influenzae PittEE hypothetical protein YP_001290991.1 1248011 D 374930 CDS YP_001290992.1 148826239 5226139 1248606..1249124 1 NC_009566.1 COG1934 Uncharacterized protein conserved in bacteria; hypothetical protein 1249124 5226139 CGSHiEE_06300 Haemophilus influenzae PittEE hypothetical protein YP_001290992.1 1248606 D 374930 CDS YP_001290993.1 148826240 5226258 1249128..1249853 1 NC_009566.1 COG1137 ABC-type (unclassified) transport system, ATPase component; ABC transporter ATP-binding protein 1249853 5226258 CGSHiEE_06305 Haemophilus influenzae PittEE ABC transporter ATP-binding protein YP_001290993.1 1249128 D 374930 CDS YP_001290994.1 148826241 5226259 1249856..1250350 1 NC_009566.1 COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); nitrogen regulatory IIA protein 1250350 5226259 CGSHiEE_06310 Haemophilus influenzae PittEE nitrogen regulatory IIA protein YP_001290994.1 1249856 D 374930 CDS YP_001290995.1 148826242 5226260 1250368..1251315 1 NC_009566.1 COG1660 Predicted P-loop-containing kinase; hypothetical protein 1251315 5226260 CGSHiEE_06315 Haemophilus influenzae PittEE hypothetical protein YP_001290995.1 1250368 D 374930 CDS YP_001290996.1 148826243 5226261 complement(1251271..1252428) 1 NC_009566.1 COG1605 Chorismate mutase; chorismate mutase/prephenate dehydratase 1252428 5226261 CGSHiEE_06320 Haemophilus influenzae PittEE chorismate mutase/prephenate dehydratase YP_001290996.1 1251271 R 374930 CDS YP_001290997.1 148826244 5226262 complement(1252555..1253472) 1 NC_009566.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 1253472 lpxC 5226262 lpxC Haemophilus influenzae PittEE UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_001290997.1 1252555 R 374930 CDS YP_001290998.1 148826245 5226263 complement(1253511..1254776) 1 NC_009566.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1254776 5226263 CGSHiEE_06330 Haemophilus influenzae PittEE cell division protein FtsZ YP_001290998.1 1253511 R 374930 CDS YP_001290999.1 148826246 5226264 complement(1256157..1256921) 1 NC_009566.1 COG1589 Cell division septal protein; cell division protein FtsZ 1256921 5226264 CGSHiEE_06345 Haemophilus influenzae PittEE cell division protein FtsZ YP_001290999.1 1256157 R 374930 CDS YP_001291000.1 148826247 5225598 complement(1256921..1257814) 1 NC_009566.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 1257814 ddl 5225598 ddl Haemophilus influenzae PittEE D-alanine--D-alanine ligase YP_001291000.1 1256921 R 374930 CDS YP_001291001.1 148826248 5225599 complement(1257914..1259341) 1 NC_009566.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 1259341 murC 5225599 murC Haemophilus influenzae PittEE UDP-N-acetylmuramate--L-alanine ligase YP_001291001.1 1257914 R 374930 CDS YP_001291002.1 148826249 5225600 complement(1259478..1260533) 1 NC_009566.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 1260533 murG 5225600 murG Haemophilus influenzae PittEE undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_001291002.1 1259478 R 374930 CDS YP_001291003.1 148826250 5225601 complement(1260545..1261729) 1 NC_009566.1 COG0772 Bacterial cell division membrane protein; N-acetylglucosaminyl transferase 1261729 murG 5225601 murG Haemophilus influenzae PittEE N-acetylglucosaminyl transferase YP_001291003.1 1260545 R 374930 CDS YP_001291004.1 148826251 5225602 complement(1261751..1263064) 1 NC_009566.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 1263064 murD 5225602 murD Haemophilus influenzae PittEE UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_001291004.1 1261751 R 374930 CDS YP_001291005.1 148826252 5225603 complement(1263176..1264258) 1 NC_009566.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 1264258 mraY 5225603 mraY Haemophilus influenzae PittEE phospho-N-acetylmuramoyl-pentapeptide- transferase YP_001291005.1 1263176 R 374930 CDS YP_001291006.1 148826253 5226078 complement(1264252..1265625) 1 NC_009566.1 COG0770 UDP-N-acetylmuramyl pentapeptide synthase; phospho-N-acetylmuramoyl-pentapeptide- transferase 1265625 mraY 5226078 mraY Haemophilus influenzae PittEE phospho-N-acetylmuramoyl-pentapeptide- transferase YP_001291006.1 1264252 R 374930 CDS YP_001291007.1 148826254 5226079 complement(1265639..1267105) 1 NC_009566.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1267105 murE 5226079 murE Haemophilus influenzae PittEE UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_001291007.1 1265639 R 374930 CDS YP_001291008.1 148826255 5226080 complement(1267115..1268947) 1 NC_009566.1 COG0768 Cell division protein FtsI/penicillin-binding protein 2; peptidoglycan synthetase FtsI 1268947 5226080 CGSHiEE_06390 Haemophilus influenzae PittEE peptidoglycan synthetase FtsI YP_001291008.1 1267115 R 374930 CDS YP_001291009.1 148826256 5226081 complement(1268959..1269282) 1 NC_009566.1 COG3116 Cell division protein; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1269282 murE 5226081 murE Haemophilus influenzae PittEE UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_001291009.1 1268959 R 374930 CDS YP_001291010.1 148826257 5226082 complement(1269285..1270250) 1 NC_009566.1 COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis; S-adenosyl-methyltransferase MraW 1270250 mraW 5226082 mraW Haemophilus influenzae PittEE S-adenosyl-methyltransferase MraW YP_001291010.1 1269285 R 374930 CDS YP_001291011.1 148826258 5226083 complement(1270281..1270736) 1 NC_009566.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 1270736 5226083 CGSHiEE_06405 Haemophilus influenzae PittEE cell division protein MraZ YP_001291011.1 1270281 R 374930 CDS YP_001291012.1 148826259 5226084 complement(1270938..1272473) 1 NC_009566.1 COG1966 Carbon starvation protein, predicted membrane protein; carbon starvation membrane protein 1272473 5226084 CGSHiEE_06410 Haemophilus influenzae PittEE carbon starvation membrane protein YP_001291012.1 1270938 R 374930 CDS YP_001291013.1 148826260 5225946 1272721..1272951 1 NC_009566.1 COG0777 Acetyl-CoA carboxylase beta subunit; hypothetical protein 1272951 5225946 CGSHiEE_06415 Haemophilus influenzae PittEE hypothetical protein YP_001291013.1 1272721 D 374930 CDS YP_001291014.1 148826261 5225947 complement(1273601..1274554) 1 NC_009566.1 COG0176 Transaldolase; transaldolase B 1274554 5225947 CGSHiEE_06420 Haemophilus influenzae PittEE transaldolase B YP_001291014.1 1273601 R 374930 CDS YP_001291015.1 148826262 5225948 1274849..1276486 1 NC_009566.1 COG4166 ABC-type oligopeptide transport system, periplasmic component; transaldolase B 1276486 5225948 CGSHiEE_06425 Haemophilus influenzae PittEE transaldolase B YP_001291015.1 1274849 D 374930 CDS YP_001291016.1 148826263 5225949 1276567..1277487 1 NC_009566.1 COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; oligopeptide transporter permease 1277487 oppB 5225949 oppB Haemophilus influenzae PittEE oligopeptide transporter permease YP_001291016.1 1276567 D 374930 CDS YP_001291017.1 148826264 5225950 1277497..1278432 1 NC_009566.1 COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; oligopeptide permease ABC transporter membrane protein 1278432 oppB 5225950 oppB Haemophilus influenzae PittEE oligopeptide permease ABC transporter membrane protein YP_001291017.1 1277497 D 374930 CDS YP_001291018.1 148826265 5225951 1278442..1279413 1 NC_009566.1 COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component; oligopeptide transporter ATP-binding protein 1279413 oppD 5225951 oppD Haemophilus influenzae PittEE oligopeptide transporter ATP-binding protein YP_001291018.1 1278442 D 374930 CDS YP_001291019.1 148826266 5225952 1279410..1280408 1 NC_009566.1 COG4608 ABC-type oligopeptide transport system, ATPase component; oligopeptide transport ATP-binding protein 1280408 5225952 CGSHiEE_06445 Haemophilus influenzae PittEE oligopeptide transport ATP-binding protein YP_001291019.1 1279410 D 374930 CDS YP_001291020.1 148826267 5225953 1281420..1282037 1 NC_009566.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 1282037 engB 5225953 engB Haemophilus influenzae PittEE ribosome biogenesis GTP-binding protein YsxC YP_001291020.1 1281420 D 374930 CDS YP_001291021.1 148826268 5226234 1282153..1283682 1 NC_009566.1 COG0606 Predicted ATPase with chaperone activity; GTPase EngB 1283682 5226234 CGSHiEE_06465 Haemophilus influenzae PittEE GTPase EngB YP_001291021.1 1282153 D 374930 CDS YP_001291022.1 148826269 5226235 complement(1283716..1284387) 1 NC_009566.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 1284387 5226235 CGSHiEE_06470 Haemophilus influenzae PittEE deoxyribose-phosphate aldolase YP_001291022.1 1283716 R 374930 CDS YP_001291023.1 148826270 5226236 1284498..1285001 1 NC_009566.1 COG0526 Thiol-disulfide isomerase and thioredoxins; deoxyribose-phosphate aldolase 1285001 5226236 CGSHiEE_06475 Haemophilus influenzae PittEE deoxyribose-phosphate aldolase YP_001291023.1 1284498 D 374930 CDS YP_001291024.1 148826271 5226237 1285109..1285981 1 NC_009566.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-mannoheptose-6-epimerase 1285981 rfaD 5226237 rfaD Haemophilus influenzae PittEE ADP-L-glycero-D-mannoheptose-6-epimerase YP_001291024.1 1285109 D 374930 CDS YP_001291025.1 148826272 5226238 complement(1286032..1287249) 1 NC_009566.1 ADP-L-glycero-D-mannoheptose-6-epimerase 1287249 rfaD 5226238 rfaD Haemophilus influenzae PittEE ADP-L-glycero-D-mannoheptose-6-epimerase YP_001291025.1 1286032 R 374930 CDS YP_001291026.1 148826273 5226239 complement(1287416..1287514) 1 NC_009566.1 COG1070 Sugar (pentulose and hexulose) kinases; hypothetical protein 1287514 5226239 CGSHiEE_06490 Haemophilus influenzae PittEE hypothetical protein YP_001291026.1 1287416 R 374930 CDS YP_001291027.1 148826274 5225657 complement(1287571..1288890) 1 NC_009566.1 catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase 1288890 5225657 CGSHiEE_06495 Haemophilus influenzae PittEE xylose isomerase YP_001291027.1 1287571 R 374930 CDS YP_001291028.1 148826275 5225658 1289124..1290122 1 NC_009566.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 1290122 xylF 5225658 xylF Haemophilus influenzae PittEE D-xylose transporter subunit XylF YP_001291028.1 1289124 D 374930 CDS YP_001291029.1 148826276 5225659 1291687..1292814 1 NC_009566.1 COG4214 ABC-type xylose transport system, permease component; D-xylose ABC transporter permease protein 1292814 5225659 CGSHiEE_06515 Haemophilus influenzae PittEE D-xylose ABC transporter permease protein YP_001291029.1 1291687 D 374930 CDS YP_001291030.1 148826277 5225660 1293089..1294261 1 NC_009566.1 COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; putative aspartate aminotransferase 1294261 5225660 CGSHiEE_06520 Haemophilus influenzae PittEE putative aspartate aminotransferase YP_001291030.1 1293089 D 374930 CDS YP_001291031.1 148826278 5225661 1294263..1295669 1 NC_009566.1 COG1757 Na+/H+ antiporter; Na(+)/H(+) antiporter 1295669 5225661 CGSHiEE_06525 Haemophilus influenzae PittEE Na(+)/H(+) antiporter YP_001291031.1 1294263 D 374930 CDS YP_001291032.1 148826279 5225662 1295781..1296944 1 NC_009566.1 COG1609 Transcriptional regulators; xylose operon regulatory protein 1296944 5225662 CGSHiEE_06530 Haemophilus influenzae PittEE xylose operon regulatory protein YP_001291032.1 1295781 D 374930 CDS YP_001291033.1 148826280 5225931 1297020..1298060 1 NC_009566.1 COG0859 ADP-heptose:LPS heptosyltransferase; ADP-heptose--lipooligosaccharide heptosyltransferase II 1298060 5225931 CGSHiEE_06535 Haemophilus influenzae PittEE ADP-heptose--lipooligosaccharide heptosyltransferase II YP_001291033.1 1297020 D 374930 CDS YP_001291034.1 148826281 5225932 complement(1298169..1299392) 1 NC_009566.1 COG0477 Permeases of the major facilitator superfamily; transporter protein 1299392 5225932 CGSHiEE_06540 Haemophilus influenzae PittEE transporter protein YP_001291034.1 1298169 R 374930 CDS YP_001291035.1 148826282 5225933 complement(1299868..1300818) 1 NC_009566.1 COG0031 Cysteine synthase; D-xylose transporter subunit 1300818 5225933 CGSHiEE_06545 Haemophilus influenzae PittEE D-xylose transporter subunit YP_001291035.1 1299868 R 374930 CDS YP_001291036.1 148826283 5225934 complement(1300918..1301736) 1 NC_009566.1 putative role in sulfur assimilation; putative sulfate transport protein CysZ 1301736 5225934 CGSHiEE_06550 Haemophilus influenzae PittEE putative sulfate transport protein CysZ YP_001291036.1 1300918 R 374930 CDS YP_001291037.1 148826284 5225935 1301889..1302875 1 NC_009566.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA 1302875 5225935 CGSHiEE_06555 Haemophilus influenzae PittEE cell division protein ZipA YP_001291037.1 1301889 D 374930 CDS YP_001291038.1 148826285 5225936 1302987..1304999 1 NC_009566.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 1304999 ligA 5225936 ligA Haemophilus influenzae PittEE NAD-dependent DNA ligase LigA YP_001291038.1 1302987 D 374930 CDS YP_001291039.1 148826286 5225937 complement(1305004..1305303) 1 NC_009566.1 hypothetical protein 1305303 5225937 CGSHiEE_06565 Haemophilus influenzae PittEE hypothetical protein YP_001291039.1 1305004 R 374930 CDS YP_001291040.1 148826287 5225478 complement(1305314..1305499) 1 NC_009566.1 hypothetical protein 1305499 5225478 CGSHiEE_06570 Haemophilus influenzae PittEE hypothetical protein YP_001291040.1 1305314 R 374930 CDS YP_001291041.1 148826288 5225479 complement(1305560..1305841) 1 NC_009566.1 COG0272 NAD-dependent DNA ligase (contains BRCT domain type II); hypothetical protein 1305841 5225479 CGSHiEE_06575 Haemophilus influenzae PittEE hypothetical protein YP_001291041.1 1305560 R 374930 CDS YP_001291042.1 148826289 5225480 complement(1305934..1306851) 1 NC_009566.1 COG4235 Cytochrome c biogenesis factor; TPR repeat-containing protein 1306851 5225480 CGSHiEE_06580 Haemophilus influenzae PittEE TPR repeat-containing protein YP_001291042.1 1305934 R 374930 CDS YP_001291043.1 148826290 5225481 complement(1306852..1307292) 1 NC_009566.1 COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes; cytochrome C-type biogenesis protein 1307292 5225481 CGSHiEE_06585 Haemophilus influenzae PittEE cytochrome C-type biogenesis protein YP_001291043.1 1306852 R 374930 CDS YP_001291044.1 148826291 5225482 complement(1307312..1307800) 1 NC_009566.1 COG0526 Thiol-disulfide isomerase and thioredoxins; thiol-disulfide interchange protein 1307800 5225482 CGSHiEE_06590 Haemophilus influenzae PittEE thiol-disulfide interchange protein YP_001291044.1 1307312 R 374930 CDS YP_001291045.1 148826292 5225483 complement(1307999..1309945) 1 NC_009566.1 COG1138 Cytochrome c biogenesis factor; cytochrome C-type biogenesis protein 1309945 5225483 CGSHiEE_06595 Haemophilus influenzae PittEE cytochrome C-type biogenesis protein YP_001291045.1 1307999 R 374930 CDS YP_001291046.1 148826293 5225484 complement(1309942..1310463) 1 NC_009566.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 1310463 5225484 CGSHiEE_06600 Haemophilus influenzae PittEE cytochrome c-type biogenesis protein CcmE YP_001291046.1 1309942 R 374930 CDS YP_001291047.1 148826294 5226163 complement(1310460..1310663) 1 NC_009566.1 COG3114 Heme exporter protein D; heme exporter protein D 1310663 5226163 CGSHiEE_06605 Haemophilus influenzae PittEE heme exporter protein D YP_001291047.1 1310460 R 374930 CDS YP_001291048.1 148826295 5226164 complement(1310705..1311445) 1 NC_009566.1 COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component; heme exporter protein C 1311445 5226164 CGSHiEE_06610 Haemophilus influenzae PittEE heme exporter protein C YP_001291048.1 1310705 R 374930 CDS YP_001291049.1 148826296 5226165 complement(1311505..1312170) 1 NC_009566.1 COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component; heme exporter protein B 1312170 5226165 CGSHiEE_06615 Haemophilus influenzae PittEE heme exporter protein B YP_001291049.1 1311505 R 374930 CDS YP_001291050.1 148826297 5226166 complement(1312175..1312813) 1 NC_009566.1 ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 1312813 5226166 CGSHiEE_06620 Haemophilus influenzae PittEE cytochrome c biogenesis protein CcmA YP_001291050.1 1312175 R 374930 CDS YP_001291051.1 148826298 5226167 1313062..1313697 1 NC_009566.1 COG0605 Superoxide dismutase; superoxide dismutase (Mn) 1313697 5226167 CGSHiEE_06625 Haemophilus influenzae PittEE superoxide dismutase (Mn) YP_001291051.1 1313062 D 374930 CDS YP_001291052.1 148826299 5226168 1314116..1314910 1 NC_009566.1 COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component; ABC transporter ATPase 1314910 5226168 CGSHiEE_06630 Haemophilus influenzae PittEE ABC transporter ATPase YP_001291052.1 1314116 D 374930 CDS YP_001291053.1 148826300 5226169 1314907..1315692 1 NC_009566.1 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component; ABC transporter permease 1315692 5226169 CGSHiEE_06635 Haemophilus influenzae PittEE ABC transporter permease YP_001291053.1 1314907 D 374930 CDS YP_001291054.1 148826301 5225586 1315702..1316202 1 NC_009566.1 COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component; ABC transporter periplasmic protein 1316202 5225586 CGSHiEE_06640 Haemophilus influenzae PittEE ABC transporter periplasmic protein YP_001291054.1 1315702 D 374930 CDS YP_001291055.1 148826302 5225587 1316235..1316879 1 NC_009566.1 COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component; ABC transporter 1316879 5225587 CGSHiEE_06645 Haemophilus influenzae PittEE ABC transporter YP_001291055.1 1316235 D 374930 CDS YP_001291056.1 148826303 5225588 1316890..1317207 1 NC_009566.1 COG3113 Predicted NTP binding protein (contains STAS domain); NTP binding protein, contains STAS domain 1317207 5225588 CGSHiEE_06650 Haemophilus influenzae PittEE NTP binding protein, contains STAS domain YP_001291056.1 1316890 D 374930 CDS YP_001291057.1 148826304 5225589 1317228..1317485 1 NC_009566.1 COG5007 Predicted transcriptional regulator, BolA superfamily; NAD-dependent DNA ligase LigA 1317485 ligA 5225589 ligA Haemophilus influenzae PittEE NAD-dependent DNA ligase LigA YP_001291057.1 1317228 D 374930 CDS YP_001291058.1 148826305 5225590 1317496..1318770 1 NC_009566.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1318770 5225590 CGSHiEE_06660 Haemophilus influenzae PittEE UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_001291058.1 1317496 D 374930 CDS YP_001291059.1 148826306 5225591 1319071..1319844 1 NC_009566.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; amino-acid ABC transporter binding protein 1319844 5225591 CGSHiEE_06665 Haemophilus influenzae PittEE amino-acid ABC transporter binding protein YP_001291059.1 1319071 D 374930 CDS YP_001291060.1 148826307 5225592 1320555..1321322 1 NC_009566.1 COG1126 ABC-type polar amino acid transport system, ATPase component; putative amino-acid ABC transporter ATP-binding protein 1321322 5225592 CGSHiEE_06680 Haemophilus influenzae PittEE putative amino-acid ABC transporter ATP-binding protein YP_001291060.1 1320555 D 374930 CDS YP_001291061.1 148826308 5225846 1321503..1322183 1 NC_009566.1 COG3201 Nicotinamide mononucleotide transporter; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1322183 5225846 CGSHiEE_06685 Haemophilus influenzae PittEE UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_001291061.1 1321503 D 374930 CDS YP_001291062.1 148826309 5225847 complement(1322325..1323962) 1 NC_009566.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 1323962 pyrG 5225847 pyrG Haemophilus influenzae PittEE CTP synthetase YP_001291062.1 1322325 R 374930 CDS YP_001291063.1 148826310 5225848 1323991..1324170 1 NC_009566.1 COG0504 CTP synthase (UTP-ammonia lyase); hypothetical protein 1324170 5225848 CGSHiEE_06695 Haemophilus influenzae PittEE hypothetical protein YP_001291063.1 1323991 D 374930 CDS YP_001291064.1 148826311 5225849 1324615..1326180 1 NC_009566.1 COG1271 Cytochrome bd-type quinol oxidase, subunit 1; cytochrome oxidase subunit I 1326180 5225849 CGSHiEE_06700 Haemophilus influenzae PittEE cytochrome oxidase subunit I YP_001291064.1 1324615 D 374930 CDS YP_001291065.1 148826312 5225850 1326195..1327331 1 NC_009566.1 putative cytochrome oxidase subunit II 1327331 5225850 CGSHiEE_06705 Haemophilus influenzae PittEE putative cytochrome oxidase subunit II YP_001291065.1 1326195 D 374930 CDS YP_001291066.1 148826313 5225851 1327343..1327441 1 NC_009566.1 COG1294 Cytochrome bd-type quinol oxidase, subunit 2; hypothetical protein 1327441 5225851 CGSHiEE_06710 Haemophilus influenzae PittEE hypothetical protein YP_001291066.1 1327343 D 374930 CDS YP_001291067.1 148826314 5225852 1327597..1328049 1 NC_009566.1 COG2707 Predicted membrane protein; hypothetical protein 1328049 5225852 CGSHiEE_06715 Haemophilus influenzae PittEE hypothetical protein YP_001291067.1 1327597 D 374930 CDS YP_001291068.1 148826315 5226036 1328050..1328424 1 NC_009566.1 COG2363 Uncharacterized small membrane protein; CTP synthetase 1328424 5226036 CGSHiEE_06720 Haemophilus influenzae PittEE CTP synthetase YP_001291068.1 1328050 D 374930 CDS YP_001291069.1 148826316 5226037 1328421..1332335 1 NC_009566.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1332335 5226037 CGSHiEE_06725 Haemophilus influenzae PittEE ATP-dependent RNA helicase HrpA YP_001291069.1 1328421 D 374930 CDS YP_001291070.1 148826317 5226038 1332359..1333243 1 NC_009566.1 COG0466 ATP-dependent Lon protease, bacterial type; ATP-dependent RNA helicase HrpA 1333243 5226038 CGSHiEE_06730 Haemophilus influenzae PittEE ATP-dependent RNA helicase HrpA YP_001291070.1 1332359 D 374930 CDS YP_001291071.1 148826318 5226039 1333973..1335499 1 NC_009566.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 1335499 nrfA 5226039 nrfA Haemophilus influenzae PittEE cytochrome c552 YP_001291071.1 1333973 D 374930 CDS YP_001291072.1 148826319 5226040 1335576..1336226 1 NC_009566.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 1336226 5226040 CGSHiEE_06740 Haemophilus influenzae PittEE cytochrome c nitrite reductase pentaheme subunit YP_001291072.1 1335576 D 374930 CDS YP_001291073.1 148826320 5226041 1336223..1336900 1 NC_009566.1 COG0437 Fe-S-cluster-containing hydrogenase components 1; Fe-S-cluster-containing hydrogenase subunit NrfC 1336900 5226041 CGSHiEE_06745 Haemophilus influenzae PittEE Fe-S-cluster-containing hydrogenase subunit NrfC YP_001291073.1 1336223 D 374930 CDS YP_001291074.1 148826321 5226042 complement(1338100..1338813) 1 NC_009566.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 1338813 pyrH 5226042 pyrH Haemophilus influenzae PittEE uridylate kinase YP_001291074.1 1338100 R 374930 CDS YP_001291075.1 148826322 5226064 1338945..1340504 1 NC_009566.1 COG2194 Predicted membrane-associated, metal-dependent hydrolase; PE--lipooligosaccharide phosphorylethanolamine transferase 1340504 5226064 CGSHiEE_06765 Haemophilus influenzae PittEE PE--lipooligosaccharide phosphorylethanolamine transferase YP_001291075.1 1338945 D 374930 CDS YP_001291076.1 148826323 5226065 1340590..1341036 1 NC_009566.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 1341036 fabZ 5226065 fabZ Haemophilus influenzae PittEE (3R)-hydroxymyristoyl-ACP dehydratase YP_001291076.1 1340590 D 374930 CDS YP_001291077.1 148826324 5226066 1341050..1341838 1 NC_009566.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 1341838 5226066 CGSHiEE_06775 Haemophilus influenzae PittEE UDP-N-acetylglucosamine acyltransferase YP_001291077.1 1341050 D 374930 CDS YP_001291078.1 148826325 5226067 1341905..1343077 1 NC_009566.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 1343077 lpxB 5226067 lpxB Haemophilus influenzae PittEE lipid-A-disaccharide synthase YP_001291078.1 1341905 D 374930 CDS YP_001291079.1 148826326 5226068 1343070..1343663 1 NC_009566.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1343663 rnhB 5226068 rnhB Haemophilus influenzae PittEE ribonuclease HII YP_001291079.1 1343070 D 374930 CDS YP_001291080.1 148826327 5226069 1343865..1346006 1 NC_009566.1 COG2189 Adenine specific DNA methylase Mod; putative type III restriction/modification system modification methylase 1346006 5226069 CGSHiEE_06790 Haemophilus influenzae PittEE putative type III restriction/modification system modification methylase YP_001291080.1 1343865 D 374930 CDS YP_001291081.1 148826328 5226070 complement(1348884..1349225) 1 NC_009566.1 COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit; hypothetical protein 1349225 5226070 CGSHiEE_06805 Haemophilus influenzae PittEE hypothetical protein YP_001291081.1 1348884 R 374930 CDS YP_001291082.1 148826329 5225989 1349337..1350233 1 NC_009566.1 COG2207 AraC-type DNA-binding domain-containing proteins; transcriptional regulator AraC family protein 1350233 5225989 CGSHiEE_06810 Haemophilus influenzae PittEE transcriptional regulator AraC family protein YP_001291082.1 1349337 D 374930 CDS YP_001291083.1 148826330 5225990 1350312..1352156 1 NC_009566.1 COG1132 ABC-type multidrug transport system, ATPase and permease components; ABC transporter ATP-binding protein 1352156 5225990 CGSHiEE_06815 Haemophilus influenzae PittEE ABC transporter ATP-binding protein YP_001291083.1 1350312 D 374930 CDS YP_001291084.1 148826331 5225991 complement(1352281..1352559) 1 NC_009566.1 hypothetical protein 1352559 5225991 CGSHiEE_06820 Haemophilus influenzae PittEE hypothetical protein YP_001291084.1 1352281 R 374930 CDS YP_001291085.1 148826332 5225992 complement(1352568..1352930) 1 NC_009566.1 COG2608 Copper chaperone; hypothetical protein 1352930 5225992 CGSHiEE_06825 Haemophilus influenzae PittEE hypothetical protein YP_001291085.1 1352568 R 374930 CDS YP_001291086.1 148826333 5225993 complement(1352905..1354014) 1 NC_009566.1 COG1305 Transglutaminase-like enzymes, putative cysteine proteases; hypothetical protein 1354014 5225993 CGSHiEE_06830 Haemophilus influenzae PittEE hypothetical protein YP_001291086.1 1352905 R 374930 CDS YP_001291087.1 148826334 5225994 1354268..1356562 1 NC_009566.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; anaerobic dimethyl sulfoxide reductase chain A 1356562 5225994 CGSHiEE_06835 Haemophilus influenzae PittEE anaerobic dimethyl sulfoxide reductase chain A YP_001291087.1 1354268 D 374930 CDS YP_001291088.1 148826335 5225995 1357317..1358156 1 NC_009566.1 COG3302 DMSO reductase anchor subunit; anaerobic dimethyl sulfoxide reductase chain C 1358156 5225995 CGSHiEE_06850 Haemophilus influenzae PittEE anaerobic dimethyl sulfoxide reductase chain C YP_001291088.1 1357317 D 374930 CDS YP_001291089.1 148826336 5225731 1358268..1358879 1 NC_009566.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1358879 5225731 CGSHiEE_06855 Haemophilus influenzae PittEE twin-argninine leader-binding protein DmsD YP_001291089.1 1358268 D 374930 CDS YP_001291090.1 148826337 5225732 1358879..1359379 1 NC_009566.1 ferredoxin 1359379 5225732 CGSHiEE_06860 Haemophilus influenzae PittEE ferredoxin YP_001291090.1 1358879 D 374930 CDS YP_001291091.1 148826338 5225733 complement(1359737..1360291) 1 NC_009566.1 UDP-N-acetylglucosamine acyltransferase 1360291 5225733 CGSHiEE_06865 Haemophilus influenzae PittEE UDP-N-acetylglucosamine acyltransferase YP_001291091.1 1359737 R 374930 CDS YP_001291092.1 148826339 5225734 1360516..1360983 1 NC_009566.1 hypothetical protein 1360983 5225734 CGSHiEE_06870 Haemophilus influenzae PittEE hypothetical protein YP_001291092.1 1360516 D 374930 CDS YP_001291093.1 148826340 5225735 1361167..1362003 1 NC_009566.1 hypothetical protein 1362003 5225735 CGSHiEE_06875 Haemophilus influenzae PittEE hypothetical protein YP_001291093.1 1361167 D 374930 CDS YP_001291094.1 148826341 5225736 complement(1362184..1362729) 1 NC_009566.1 hypothetical protein 1362729 5225736 CGSHiEE_06880 Haemophilus influenzae PittEE hypothetical protein YP_001291094.1 1362184 R 374930 CDS YP_001291095.1 148826342 5225737 complement(1362729..1363676) 1 NC_009566.1 responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 1363676 5225737 CGSHiEE_06885 Haemophilus influenzae PittEE magnesium/nickel/cobalt transporter CorA YP_001291095.1 1362729 R 374930 CDS YP_001291096.1 148826343 5225738 complement(1363972..1364463) 1 NC_009566.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; putative nucleotide-binding protein 1364463 5225738 CGSHiEE_06890 Haemophilus influenzae PittEE putative nucleotide-binding protein YP_001291096.1 1363972 R 374930 CDS YP_001291097.1 148826344 5226120 complement(1364481..1365425) 1 NC_009566.1 catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 1365425 serB 5226120 serB Haemophilus influenzae PittEE phosphoserine phosphatase YP_001291097.1 1364481 R 374930 CDS YP_001291098.1 148826345 5226121 1365806..1367803 1 NC_009566.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1367803 5226121 CGSHiEE_06900 Haemophilus influenzae PittEE transketolase YP_001291098.1 1365806 D 374930 CDS YP_001291099.1 148826346 5226122 complement(1367928..1368929) 1 NC_009566.1 COG0502 Biotin synthase and related enzymes; biotin synthase 1368929 5226122 CGSHiEE_06905 Haemophilus influenzae PittEE biotin synthase YP_001291099.1 1367928 R 374930 CDS YP_001291100.1 148826347 5226123 complement(1369672..1371288) 1 NC_009566.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein 1371288 thiP 5226123 thiP Haemophilus influenzae PittEE thiamine transporter membrane protein YP_001291100.1 1369672 R 374930 CDS YP_001291101.1 148826348 5226124 complement(1371293..1372291) 1 NC_009566.1 COG4143 ABC-type thiamine transport system, periplasmic component; thiamin ABC transporter periplasmic-binding protein 1372291 5226124 CGSHiEE_06925 Haemophilus influenzae PittEE thiamin ABC transporter periplasmic-binding protein YP_001291101.1 1371293 R 374930 CDS YP_001291102.1 148826349 5226125 complement(1372538..1372885) 1 NC_009566.1 COG1555 DNA uptake protein and related DNA-binding proteins; hypothetical protein 1372885 thiP 5226125 thiP Haemophilus influenzae PittEE hypothetical protein YP_001291102.1 1372538 R 374930 CDS YP_001291103.1 148826350 5224704 complement(1373054..1373998) 1 NC_009566.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1373998 ispH 5224704 ispH Haemophilus influenzae PittEE 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_001291103.1 1373054 R 374930 CDS YP_001291104.1 148826351 5224705 complement(1376227..1378095) 1 NC_009566.1 COG0760 Parvulin-like peptidyl-prolyl isomerase; lipoprotein signal peptidase 1378095 lspA 5224705 lspA Haemophilus influenzae PittEE lipoprotein signal peptidase YP_001291104.1 1376227 R 374930 CDS YP_001291105.1 148826352 5224706 complement(1378285..1379643) 1 NC_009566.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 1379643 trmE 5224706 trmE Haemophilus influenzae PittEE tRNA modification GTPase TrmE YP_001291105.1 1378285 R 374930 CDS YP_001291106.1 148826353 5224707 complement(1380079..1381704) 1 NC_009566.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; putative inner membrane protein translocase component YidC 1381704 5224707 CGSHiEE_06970 Haemophilus influenzae PittEE putative inner membrane protein translocase component YidC YP_001291106.1 1380079 R 374930 CDS YP_001291107.1 148826354 5224708 complement(1381704..1382288) 1 NC_009566.1 COG0594 RNase P protein component; ribonuclease P 1382288 rnpA 5224708 rnpA Haemophilus influenzae PittEE ribonuclease P YP_001291107.1 1381704 R 374930 CDS YP_001291108.1 148826355 5224709 complement(1382308..1382442) 1 NC_009566.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 1382442 rpmH 5224709 rpmH Haemophilus influenzae PittEE 50S ribosomal protein L34 YP_001291108.1 1382308 R 374930 CDS YP_001291109.1 148826356 5226071 complement(1382623..1384068) 1 NC_009566.1 hypothetical protein 1384068 5226071 CGSHiEE_06985 Haemophilus influenzae PittEE hypothetical protein YP_001291109.1 1382623 R 374930 CDS YP_001291110.1 148826357 5226072 1384166..1386091 1 NC_009566.1 COG0457 FOG: TPR repeat; transferrin-binding protein 2 1386091 5226072 CGSHiEE_06990 Haemophilus influenzae PittEE transferrin-binding protein 2 YP_001291110.1 1384166 D 374930 CDS YP_001291111.1 148826358 5226073 1386133..1388880 1 NC_009566.1 COG1629 Outer membrane receptor proteins, mostly Fe transport; 50S ribosomal protein L34 1388880 rpmH 5226073 rpmH Haemophilus influenzae PittEE 50S ribosomal protein L34 YP_001291111.1 1386133 D 374930 CDS YP_001291112.1 148826359 5226074 1389072..1390436 1 NC_009566.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1390436 dnaA 5226074 dnaA Haemophilus influenzae PittEE chromosomal replication initiation protein YP_001291112.1 1389072 D 374930 CDS YP_001291113.1 148826360 5226075 1390449..1391549 1 NC_009566.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 1391549 5226075 CGSHiEE_07005 Haemophilus influenzae PittEE DNA polymerase III subunit beta YP_001291113.1 1390449 D 374930 CDS YP_001291114.1 148826361 5226076 1391524..1392606 1 NC_009566.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 1392606 recF 5226076 recF Haemophilus influenzae PittEE recombination protein F YP_001291114.1 1391524 D 374930 CDS YP_001291115.1 148826362 5226077 1392872..1398148 1 NC_009566.1 COG3468 Type V secretory pathway, adhesin AidA; recombination protein F 1398148 recF 5226077 recF Haemophilus influenzae PittEE recombination protein F YP_001291115.1 1392872 D 374930 CDS YP_001291116.1 148826363 5226098 complement(1398262..1398864) 1 NC_009566.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 1398864 leuD 5226098 leuD Haemophilus influenzae PittEE isopropylmalate isomerase small subunit YP_001291116.1 1398262 R 374930 CDS YP_001291117.1 148826364 5226099 complement(1398889..1400298) 1 NC_009566.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 1400298 5226099 CGSHiEE_07025 Haemophilus influenzae PittEE isopropylmalate isomerase large subunit YP_001291117.1 1398889 R 374930 CDS YP_001291118.1 148826365 5226100 complement(1400473..1401549) 1 NC_009566.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 1401549 5226100 CGSHiEE_07030 Haemophilus influenzae PittEE 3-isopropylmalate dehydrogenase YP_001291118.1 1400473 R 374930 CDS YP_001291119.1 148826366 5226101 complement(1401630..1403177) 1 NC_009566.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 1403177 5226101 CGSHiEE_07035 Haemophilus influenzae PittEE 2-isopropylmalate synthase YP_001291119.1 1401630 R 374930 CDS YP_001291120.1 148826367 5226102 1403746..1404867 1 NC_009566.1 COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake; 2-isopropylmalate synthase 1404867 5226102 CGSHiEE_07040 Haemophilus influenzae PittEE 2-isopropylmalate synthase YP_001291120.1 1403746 D 374930 CDS YP_001291121.1 148826368 5226103 1404920..1405696 1 NC_009566.1 hypothetical protein 1405696 5226103 CGSHiEE_07045 Haemophilus influenzae PittEE hypothetical protein YP_001291121.1 1404920 D 374930 CDS YP_001291122.1 148826369 5226104 1405689..1406270 1 NC_009566.1 COG3022 Uncharacterized protein conserved in bacteria; hypothetical protein 1406270 5226104 CGSHiEE_07050 Haemophilus influenzae PittEE hypothetical protein YP_001291122.1 1405689 D 374930 CDS YP_001291123.1 148826370 5226105 1406366..1407331 1 NC_009566.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 1407331 5226105 CGSHiEE_07055 Haemophilus influenzae PittEE 6-phosphofructokinase YP_001291123.1 1406366 D 374930 CDS YP_001291124.1 148826371 5225818 1407575..1408060 1 NC_009566.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 1408060 smpB 5225818 smpB Haemophilus influenzae PittEE SsrA-binding protein YP_001291124.1 1407575 D 374930 CDS YP_001291125.1 148826372 5225819 complement(1408155..1408454) 1 NC_009566.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 1408454 fis 5225819 fis Haemophilus influenzae PittEE DNA-binding protein Fis YP_001291125.1 1408155 R 374930 CDS YP_001291126.1 148826373 5225820 complement(1408448..1409509) 1 NC_009566.1 COG0042 tRNA-dihydrouridine synthase; DNA-binding protein Fis 1409509 fis 5225820 fis Haemophilus influenzae PittEE DNA-binding protein Fis YP_001291126.1 1408448 R 374930 CDS YP_001291127.1 148826374 5225821 complement(1409575..1410462) 1 NC_009566.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 1410462 prmA 5225821 prmA Haemophilus influenzae PittEE ribosomal protein L11 methyltransferase YP_001291127.1 1409575 R 374930 CDS YP_001291128.1 148826375 5225822 complement(1410503..1411048) 1 NC_009566.1 COG2184 Protein involved in cell division; cell filamentation protein 1411048 5225822 CGSHiEE_07080 Haemophilus influenzae PittEE cell filamentation protein YP_001291128.1 1410503 R 374930 CDS YP_001291129.1 148826376 5225823 complement(1411081..1411953) 1 NC_009566.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; ribosomal protein L11 methyltransferase 1411953 prmA 5225823 prmA Haemophilus influenzae PittEE ribosomal protein L11 methyltransferase YP_001291129.1 1411081 R 374930 CDS YP_001291130.1 148826377 5225824 complement(1412073..1413527) 1 NC_009566.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 1413527 panF 5225824 panF Haemophilus influenzae PittEE sodium/panthothenate symporter YP_001291130.1 1412073 R 374930 CDS YP_001291131.1 148826378 5225825 complement(1413524..1413781) 1 NC_009566.1 COG3924 Predicted membrane protein; sodium/panthothenate symporter 1413781 panF 5225825 panF Haemophilus influenzae PittEE sodium/panthothenate symporter YP_001291131.1 1413524 R 374930 CDS YP_001291132.1 148826379 5226220 complement(1413986..1415332) 1 NC_009566.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 1415332 5226220 CGSHiEE_07100 Haemophilus influenzae PittEE acetyl-CoA carboxylase biotin carboxylase subunit YP_001291132.1 1413986 R 374930 CDS YP_001291133.1 148826380 5226221 complement(1415509..1415976) 1 NC_009566.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 1415976 5226221 CGSHiEE_07105 Haemophilus influenzae PittEE acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_001291133.1 1415509 R 374930 CDS YP_001291134.1 148826381 5226222 complement(1416130..1416579) 1 NC_009566.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 1416579 5226222 CGSHiEE_07110 Haemophilus influenzae PittEE 3-dehydroquinate dehydratase YP_001291134.1 1416130 R 374930 CDS YP_001291135.1 148826382 5226223 complement(1416636..1417625) 1 NC_009566.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 1417625 5226223 CGSHiEE_07115 Haemophilus influenzae PittEE O-succinylbenzoate synthase YP_001291135.1 1416636 R 374930 CDS YP_001291136.1 148826383 5226224 complement(1417694..1418551) 1 NC_009566.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 1418551 5226224 CGSHiEE_07120 Haemophilus influenzae PittEE naphthoate synthase YP_001291136.1 1417694 R 374930 CDS YP_001291137.1 148826384 5226225 1418697..1419263 1 NC_009566.1 COG0447 Dihydroxynaphthoic acid synthase; hypothetical protein 1419263 5226225 CGSHiEE_07125 Haemophilus influenzae PittEE hypothetical protein YP_001291137.1 1418697 D 374930 CDS YP_001291138.1 148826385 5226226 complement(1419336..1419599) 1 NC_009566.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 1419599 rpsT 5226226 rpsT Haemophilus influenzae PittEE 30S ribosomal protein S20 YP_001291138.1 1419336 R 374930 CDS YP_001291139.1 148826386 5226050 1421488..1422414 1 NC_009566.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1422414 5226050 CGSHiEE_07145 Haemophilus influenzae PittEE bifunctional riboflavin kinase/FMN adenylyltransferase YP_001291139.1 1421488 D 374930 CDS YP_001291140.1 148826387 5226051 1422443..1425268 1 NC_009566.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 1425268 ileS 5226051 ileS Haemophilus influenzae PittEE isoleucyl-tRNA synthetase YP_001291140.1 1422443 D 374930 CDS YP_001291141.1 148826388 5226052 1425388..1425738 1 NC_009566.1 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases; HIT-like protein 1425738 5226052 CGSHiEE_07155 Haemophilus influenzae PittEE HIT-like protein YP_001291141.1 1425388 D 374930 CDS YP_001291142.1 148826389 5226053 1425738..1426088 1 NC_009566.1 COG5633 Predicted periplasmic lipoprotein; isoleucyl-tRNA synthetase 1426088 ileS 5226053 ileS Haemophilus influenzae PittEE isoleucyl-tRNA synthetase YP_001291142.1 1425738 D 374930 CDS YP_001291143.1 148826390 5226054 1426092..1427144 1 NC_009566.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1427144 5226054 CGSHiEE_07165 Haemophilus influenzae PittEE beta-hexosaminidase YP_001291143.1 1426092 D 374930 CDS YP_001291144.1 148826391 5226055 1427141..1428319 1 NC_009566.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 1428319 rumB 5226055 rumB Haemophilus influenzae PittEE 23S rRNA methyluridine methyltransferase YP_001291144.1 1427141 D 374930 CDS YP_001291145.1 148826392 5226056 complement(1428684..1429358) 1 NC_009566.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 1429358 5226056 CGSHiEE_07175 Haemophilus influenzae PittEE cAMP-regulatory protein YP_001291145.1 1428684 R 374930 CDS YP_001291146.1 148826393 5226265 complement(1429343..1429594) 1 NC_009566.1 COG3089 Uncharacterized protein conserved in bacteria; hypothetical protein 1429594 5226265 CGSHiEE_07180 Haemophilus influenzae PittEE hypothetical protein YP_001291146.1 1429343 R 374930 CDS YP_001291147.1 148826394 5226266 complement(1429616..1430272) 1 NC_009566.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 1430272 slmA 5226266 slmA Haemophilus influenzae PittEE nucleoid occlusion protein YP_001291147.1 1429616 R 374930 CDS YP_001291148.1 148826395 5226267 complement(1430276..1430731) 1 NC_009566.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 1430731 dut 5226267 dut Haemophilus influenzae PittEE deoxyuridine 5'-triphosphate nucleotidohydrolase YP_001291148.1 1430276 R 374930 CDS YP_001291149.1 148826396 5226268 complement(1430779..1431981) 1 NC_009566.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 1431981 5226268 CGSHiEE_07195 Haemophilus influenzae PittEE bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_001291149.1 1430779 R 374930 CDS YP_001291150.1 148826397 5226269 1432166..1432810 1 NC_009566.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 1432810 radC 5226269 radC Haemophilus influenzae PittEE DNA repair protein RadC YP_001291150.1 1432166 D 374930 CDS YP_001291151.1 148826398 5226270 1433023..1433259 1 NC_009566.1 required for 70S ribosome assembly; 50S ribosomal protein L28 1433259 rpmB 5226270 rpmB Haemophilus influenzae PittEE 50S ribosomal protein L28 YP_001291151.1 1433023 D 374930 CDS YP_001291152.1 148826399 5226271 1433271..1433441 1 NC_009566.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 1433441 rpmG 5226271 rpmG Haemophilus influenzae PittEE 50S ribosomal protein L33 YP_001291152.1 1433271 D 374930 CDS YP_001291153.1 148826400 5226272 1433787..1435151 1 NC_009566.1 catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde; diaminobutyrate--2-oxoglutarate aminotransferase 1435151 5226272 CGSHiEE_07215 Haemophilus influenzae PittEE diaminobutyrate--2-oxoglutarate aminotransferase YP_001291153.1 1433787 D 374930 CDS YP_001291154.1 148826401 5225764 1435298..1435531 1 NC_009566.1 COG4456 Virulence-associated protein and related proteins; hypothetical protein 1435531 5225764 CGSHiEE_07220 Haemophilus influenzae PittEE hypothetical protein YP_001291154.1 1435298 D 374930 CDS YP_001291155.1 148826402 5225765 1435531..1435929 1 NC_009566.1 COG1487 Predicted nucleic acid-binding protein, contains PIN domain; nucleic acid-binding protein 1435929 5225765 CGSHiEE_07225 Haemophilus influenzae PittEE nucleic acid-binding protein YP_001291155.1 1435531 D 374930 CDS YP_001291156.1 148826403 5225766 1435949..1437484 1 NC_009566.1 COG0076 Glutamate decarboxylase and related PLP-dependent proteins; diaminobutyrate--2-oxoglutarate aminotransferase 1437484 5225766 CGSHiEE_07230 Haemophilus influenzae PittEE diaminobutyrate--2-oxoglutarate aminotransferase YP_001291156.1 1435949 D 374930 CDS YP_001291157.1 148826404 5225767 1437715..1438530 1 NC_009566.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 1438530 5225767 CGSHiEE_07235 Haemophilus influenzae PittEE formamidopyrimidine-DNA glycosylase YP_001291157.1 1437715 D 374930 CDS YP_001291158.1 148826405 5225768 complement(1438604..1439626) 1 NC_009566.1 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; protease DegS 1439626 5225768 CGSHiEE_07240 Haemophilus influenzae PittEE protease DegS YP_001291158.1 1438604 R 374930 CDS YP_001291159.1 148826406 5225769 complement(1439627..1440745) 1 NC_009566.1 COG0117 Pyrimidine deaminase; formamidopyrimidine-DNA glycosylase 1440745 5225769 CGSHiEE_07245 Haemophilus influenzae PittEE formamidopyrimidine-DNA glycosylase YP_001291159.1 1439627 R 374930 CDS YP_001291160.1 148826407 5225770 complement(1440748..1441197) 1 NC_009566.1 COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains; transcriptional regulator NrdR 1441197 nrdR 5225770 nrdR Haemophilus influenzae PittEE transcriptional regulator NrdR YP_001291160.1 1440748 R 374930 CDS YP_001291161.1 148826408 5225771 complement(1441252..1444617) 1 NC_009566.1 exodeoxyribonuclease V subunit gamma 1444617 5225771 CGSHiEE_07255 Haemophilus influenzae PittEE exodeoxyribonuclease V subunit gamma YP_001291161.1 1441252 R 374930 CDS YP_001291162.1 148826409 5225739 complement(1444663..1444950) 1 NC_009566.1 hypothetical protein 1444950 5225739 CGSHiEE_07260 Haemophilus influenzae PittEE hypothetical protein YP_001291162.1 1444663 R 374930 CDS YP_001291163.1 148826410 5225740 complement(1444943..1445626) 1 NC_009566.1 COG1330 Exonuclease V gamma subunit; hypothetical protein 1445626 5225740 CGSHiEE_07265 Haemophilus influenzae PittEE hypothetical protein YP_001291163.1 1444943 R 374930 CDS YP_001291164.1 148826411 5225741 complement(1445641..1446357) 1 NC_009566.1 COG4795 Type II secretory pathway, component PulJ; hypothetical protein 1446357 5225741 CGSHiEE_07270 Haemophilus influenzae PittEE hypothetical protein YP_001291164.1 1445641 R 374930 CDS YP_001291165.1 148826412 5225742 complement(1446357..1446869) 1 NC_009566.1 COG2165 Type II secretory pathway, pseudopilin PulG; hypothetical protein 1446869 5225742 CGSHiEE_07275 Haemophilus influenzae PittEE hypothetical protein YP_001291165.1 1446357 R 374930 CDS YP_001291166.1 148826413 5225743 1447069..1447872 1 NC_009566.1 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family; extragenic suppressor 1447872 5225743 CGSHiEE_07280 Haemophilus influenzae PittEE extragenic suppressor YP_001291166.1 1447069 D 374930 CDS YP_001291167.1 148826414 5225744 1447981..1449888 1 NC_009566.1 COG1138 Cytochrome c biogenesis factor; cytochrome c-type biogenesis protein NrfE 1449888 5225744 CGSHiEE_07285 Haemophilus influenzae PittEE cytochrome c-type biogenesis protein NrfE YP_001291167.1 1447981 D 374930 CDS YP_001291168.1 148826415 5225745 1449888..1450418 1 NC_009566.1 COG0526 Thiol-disulfide isomerase and thioredoxins; thiol-disulfide interchange protein 1450418 5225745 CGSHiEE_07290 Haemophilus influenzae PittEE thiol-disulfide interchange protein YP_001291168.1 1449888 D 374930 CDS YP_001291169.1 148826416 5225746 1450415..1451569 1 NC_009566.1 COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes; cytochrome C-type biogenesis protein 1451569 5225746 CGSHiEE_07295 Haemophilus influenzae PittEE cytochrome C-type biogenesis protein YP_001291169.1 1450415 D 374930 CDS YP_001291170.1 148826417 5225723 1452891..1454201 1 NC_009566.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1454201 eno 5225723 eno Haemophilus influenzae PittEE phosphopyruvate hydratase YP_001291170.1 1452891 D 374930 CDS YP_001291171.1 148826418 5225724 1454715..1455296 1 NC_009566.1 COG3210 Large exoproteins involved in heme utilization or adhesion; hypothetical protein 1455296 5225724 CGSHiEE_07325 Haemophilus influenzae PittEE hypothetical protein YP_001291171.1 1454715 D 374930 CDS YP_001291172.1 148826419 5225725 1455297..1456478 1 NC_009566.1 COG0754 Glutathionylspermidine synthase; hypothetical protein 1456478 5225725 CGSHiEE_07330 Haemophilus influenzae PittEE hypothetical protein YP_001291172.1 1455297 D 374930 CDS YP_001291173.1 148826420 5225726 complement(1456711..1458237) 1 NC_009566.1 COG0753 Catalase; phosphopyruvate hydratase 1458237 eno 5225726 eno Haemophilus influenzae PittEE phosphopyruvate hydratase YP_001291173.1 1456711 R 374930 CDS YP_001291174.1 148826421 5225727 1458504..1459412 1 NC_009566.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 1459412 glyQ 5225727 glyQ Haemophilus influenzae PittEE glycyl-tRNA synthetase subunit alpha YP_001291174.1 1458504 D 374930 CDS YP_001291175.1 148826422 5225728 1459471..1459731 1 NC_009566.1 COG4545 Glutaredoxin-related protein; glutaredoxin-like protein 1459731 5225728 CGSHiEE_07345 Haemophilus influenzae PittEE glutaredoxin-like protein YP_001291175.1 1459471 D 374930 CDS YP_001291176.1 148826423 5225729 1459761..1460126 1 NC_009566.1 COG2852 Uncharacterized protein conserved in bacteria; glycyl-tRNA synthetase subunit alpha 1460126 glyQ 5225729 glyQ Haemophilus influenzae PittEE glycyl-tRNA synthetase subunit alpha YP_001291176.1 1459761 D 374930 CDS YP_001291177.1 148826424 5225730 1460464..1462530 1 NC_009566.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 1462530 glyS 5225730 glyS Haemophilus influenzae PittEE glycyl-tRNA synthetase subunit beta YP_001291177.1 1460464 D 374930 CDS YP_001291178.1 148826425 5225644 1462892..1463431 1 NC_009566.1 putative prophage integrase 1463431 5225644 CGSHiEE_07360 Haemophilus influenzae PittEE putative prophage integrase YP_001291178.1 1462892 D 374930 CDS YP_001291179.1 148826426 5225645 1463461..1463769 1 NC_009566.1 major phage capsid protein 1463769 5225645 CGSHiEE_07365 Haemophilus influenzae PittEE major phage capsid protein YP_001291179.1 1463461 D 374930 CDS YP_001291180.1 148826427 5225646 1463769..1463993 1 NC_009566.1 COG0582 Integrase; hypothetical protein 1463993 5225646 CGSHiEE_07370 Haemophilus influenzae PittEE hypothetical protein YP_001291180.1 1463769 D 374930 CDS YP_001291181.1 148826428 5225647 1464291..1464545 1 NC_009566.1 COG2161 Antitoxin of toxin-antitoxin stability system; hypothetical protein 1464545 5225647 CGSHiEE_07375 Haemophilus influenzae PittEE hypothetical protein YP_001291181.1 1464291 D 374930 CDS YP_001291182.1 148826429 5225648 1464535..1464825 1 NC_009566.1 glycyl-tRNA synthetase subunit beta 1464825 glyS 5225648 glyS Haemophilus influenzae PittEE glycyl-tRNA synthetase subunit beta YP_001291182.1 1464535 D 374930 CDS YP_001291183.1 148826430 5225649 1465082..1465237 1 NC_009566.1 hypothetical protein 1465237 5225649 CGSHiEE_07385 Haemophilus influenzae PittEE hypothetical protein YP_001291183.1 1465082 D 374930 CDS YP_001291184.1 148826431 5225650 1465285..1465422 1 NC_009566.1 hypothetical protein 1465422 5225650 CGSHiEE_07390 Haemophilus influenzae PittEE hypothetical protein YP_001291184.1 1465285 D 374930 CDS YP_001291185.1 148826432 5225651 complement(1465604..1465894) 1 NC_009566.1 COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system; hypothetical protein 1465894 5225651 CGSHiEE_07395 Haemophilus influenzae PittEE hypothetical protein YP_001291185.1 1465604 R 374930 CDS YP_001291186.1 148826433 5226194 complement(1466072..1467106) 1 NC_009566.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 1467106 holA 5226194 holA Haemophilus influenzae PittEE DNA polymerase III subunit delta YP_001291186.1 1466072 R 374930 CDS YP_001291187.1 148826434 5226195 complement(1467106..1467609) 1 NC_009566.1 COG2980 Rare lipoprotein B; DNA polymerase III subunit delta 1467609 holA 5226195 holA Haemophilus influenzae PittEE DNA polymerase III subunit delta YP_001291187.1 1467106 R 374930 CDS YP_001291188.1 148826435 5226196 complement(1467704..1470289) 1 NC_009566.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 1470289 leuS 5226196 leuS Haemophilus influenzae PittEE leucyl-tRNA synthetase YP_001291188.1 1467704 R 374930 CDS YP_001291189.1 148826436 5226197 1470539..1471258 1 NC_009566.1 COG0020 Undecaprenyl pyrophosphate synthase; hypothetical protein 1471258 5226197 CGSHiEE_07415 Haemophilus influenzae PittEE hypothetical protein YP_001291189.1 1470539 D 374930 CDS YP_001291190.1 148826437 5226198 1471276..1472142 1 NC_009566.1 COG0575 CDP-diglyceride synthetase; CDP-diglyceride synthetase 1472142 5226198 CGSHiEE_07420 Haemophilus influenzae PittEE CDP-diglyceride synthetase YP_001291190.1 1471276 D 374930 CDS YP_001291191.1 148826438 5226199 1472152..1473483 1 NC_009566.1 COG0750 Predicted membrane-associated Zn-dependent proteases 1; hypothetical protein 1473483 5226199 CGSHiEE_07425 Haemophilus influenzae PittEE hypothetical protein YP_001291191.1 1472152 D 374930 CDS YP_001291192.1 148826439 5226200 1473503..1475908 1 NC_009566.1 COG4775 Outer membrane protein/protective antigen OMA87; protective surface antigen D15 1475908 5226200 CGSHiEE_07430 Haemophilus influenzae PittEE protective surface antigen D15 YP_001291192.1 1473503 D 374930 CDS YP_001291193.1 148826440 5226201 1476019..1476612 1 NC_009566.1 COG2825 Outer membrane protein; leucyl-tRNA synthetase 1476612 leuS 5226201 leuS Haemophilus influenzae PittEE leucyl-tRNA synthetase YP_001291193.1 1476019 D 374930 CDS YP_001291194.1 148826441 5225447 1476625..1477650 1 NC_009566.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 1477650 lpxD 5225447 lpxD Haemophilus influenzae PittEE UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_001291194.1 1476625 D 374930 CDS YP_001291195.1 148826442 5225448 complement(1477817..1478668) 1 NC_009566.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 1478668 tsf 5225448 tsf Haemophilus influenzae PittEE elongation factor Ts YP_001291195.1 1477817 R 374930 CDS YP_001291196.1 148826443 5225449 complement(1478802..1479524) 1 NC_009566.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 1479524 rpsB 5225449 rpsB Haemophilus influenzae PittEE 30S ribosomal protein S2 YP_001291196.1 1478802 R 374930 CDS YP_001291197.1 148826444 5225450 complement(1479702..1480466) 1 NC_009566.1 COG0500 SAM-dependent methyltransferases; hypothetical protein 1480466 5225450 CGSHiEE_07455 Haemophilus influenzae PittEE hypothetical protein YP_001291197.1 1479702 R 374930 CDS YP_001291198.1 148826445 5225451 complement(1480586..1482442) 1 NC_009566.1 30S ribosomal protein S2 1482442 rpsB 5225451 rpsB Haemophilus influenzae PittEE 30S ribosomal protein S2 YP_001291198.1 1480586 R 374930 CDS YP_001291199.1 148826446 5225452 1482724..1482927 1 NC_009566.1 COG0475 Kef-type K+ transport systems, membrane components; hypothetical protein 1482927 5225452 CGSHiEE_07465 Haemophilus influenzae PittEE hypothetical protein YP_001291199.1 1482724 D 374930 CDS YP_001291200.1 148826447 5225453 complement(1483025..1485730) 1 NC_009566.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1485730 5225453 CGSHiEE_07470 Haemophilus influenzae PittEE preprotein translocase subunit SecA YP_001291200.1 1483025 R 374930 CDS YP_001291201.1 148826448 5226187 complement(1485855..1486157) 1 NC_009566.1 COG0653 Preprotein translocase subunit SecA (ATPase, RNA helicase); hypothetical protein 1486157 5226187 CGSHiEE_07475 Haemophilus influenzae PittEE hypothetical protein YP_001291201.1 1485855 R 374930 CDS YP_001291202.1 148826449 5226188 1486237..1486551 1 NC_009566.1 COG4701 Uncharacterized protein conserved in bacteria; hypothetical protein 1486551 5226188 CGSHiEE_07480 Haemophilus influenzae PittEE hypothetical protein YP_001291202.1 1486237 D 374930 CDS YP_001291203.1 148826450 5226189 complement(1486614..1487099) 1 NC_009566.1 COG0590 Cytosine/adenosine deaminases; preprotein translocase subunit SecA 1487099 secA 5226189 secA Haemophilus influenzae PittEE preprotein translocase subunit SecA YP_001291203.1 1486614 R 374930 CDS YP_001291204.1 148826451 5226190 complement(1487099..1487950) 1 NC_009566.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 1487950 thyA 5226190 thyA Haemophilus influenzae PittEE thymidylate synthase YP_001291204.1 1487099 R 374930 CDS YP_001291205.1 148826452 5226191 complement(1487960..1488766) 1 NC_009566.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 1488766 5226191 CGSHiEE_07495 Haemophilus influenzae PittEE prolipoprotein diacylglyceryl transferase YP_001291205.1 1487960 R 374930 CDS YP_001291206.1 148826453 5226192 complement(1488775..1489569) 1 NC_009566.1 COG0730 Predicted permeases; hypothetical protein 1489569 thyA 5226192 thyA Haemophilus influenzae PittEE hypothetical protein YP_001291206.1 1488775 R 374930 CDS YP_001291207.1 148826454 5226193 complement(1489569..1490159) 1 NC_009566.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 1490159 5226193 CGSHiEE_07505 Haemophilus influenzae PittEE dinucleoside polyphosphate hydrolase YP_001291207.1 1489569 R 374930 CDS YP_001291208.1 148826455 5225697 complement(1490240..1491346) 1 NC_009566.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 1491346 5225697 CGSHiEE_07510 Haemophilus influenzae PittEE gamma-glutamyl kinase YP_001291208.1 1490240 R 374930 CDS YP_001291209.1 148826456 5225698 1491447..1491929 1 NC_009566.1 COG0262 Dihydrofolate reductase; dihydrofolate reductase 1491929 5225698 CGSHiEE_07515 Haemophilus influenzae PittEE dihydrofolate reductase YP_001291209.1 1491447 D 374930 CDS YP_001291210.1 148826457 5225699 1492102..1493274 1 NC_009566.1 COG1566 Multidrug resistance efflux pump; multidrug resistance protein A 1493274 5225699 CGSHiEE_07520 Haemophilus influenzae PittEE multidrug resistance protein A YP_001291210.1 1492102 D 374930 CDS YP_001291211.1 148826458 5225700 complement(1494830..1495600) 1 NC_009566.1 COG3087 Cell division protein; cell division protein 1495600 5225700 CGSHiEE_07535 Haemophilus influenzae PittEE cell division protein YP_001291211.1 1494830 R 374930 CDS YP_001291212.1 148826459 5225701 complement(1495834..1498914) 1 NC_009566.1 COG0841 Cation/multidrug efflux pump; cation/multidrug efflux pump 1498914 5225701 CGSHiEE_07540 Haemophilus influenzae PittEE cation/multidrug efflux pump YP_001291212.1 1495834 R 374930 CDS YP_001291213.1 148826460 5225702 complement(1498932..1500128) 1 NC_009566.1 COG0845 Membrane-fusion protein; putative membrane-fusion protein 1500128 5225702 CGSHiEE_07545 Haemophilus influenzae PittEE putative membrane-fusion protein YP_001291213.1 1498932 R 374930 CDS YP_001291215.1 148826462 5225962 complement(1500965..1502212) 1 NC_009566.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB 1502212 5225962 CGSHiEE_07565 Haemophilus influenzae PittEE ATP-dependent RNA helicase RhlB YP_001291215.1 1500965 R 374930 CDS YP_001291216.1 148826463 5225963 complement(1502329..1502535) 1 NC_009566.1 COG3024 Uncharacterized protein conserved in bacteria; zinc-binding protein 1502535 5225963 CGSHiEE_07570 Haemophilus influenzae PittEE zinc-binding protein YP_001291216.1 1502329 R 374930 CDS YP_001291217.1 148826464 5225964 complement(1502528..1503148) 1 NC_009566.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 1503148 coaE 5225964 coaE Haemophilus influenzae PittEE dephospho-CoA kinase YP_001291217.1 1502528 R 374930 CDS YP_001291218.1 148826465 5225965 complement(1503219..1504484) 1 NC_009566.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 1504484 glyA 5225965 glyA Haemophilus influenzae PittEE serine hydroxymethyltransferase YP_001291218.1 1503219 R 374930 CDS YP_001291219.1 148826466 5225966 complement(1504619..1505551) 1 NC_009566.1 COG0463 Glycosyltransferases involved in cell wall biogenesis; serine hydroxymethyltransferase 1505551 glyA 5225966 glyA Haemophilus influenzae PittEE serine hydroxymethyltransferase YP_001291219.1 1504619 R 374930 CDS YP_001291220.1 148826467 5225967 complement(1505538..1506824) 1 NC_009566.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 1506824 5225967 CGSHiEE_07590 Haemophilus influenzae PittEE phosphoribosylamine--glycine ligase YP_001291220.1 1505538 R 374930 CDS YP_001291221.1 148826468 5225968 complement(1507010..1508608) 1 NC_009566.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1508608 purH 5225968 purH Haemophilus influenzae PittEE bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_001291221.1 1507010 R 374930 CDS YP_001291222.1 148826469 5226085 complement(1508797..1509201) 1 NC_009566.1 COG2259 Predicted membrane protein; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1509201 purH 5226085 purH Haemophilus influenzae PittEE bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_001291222.1 1508797 R 374930 CDS YP_001291223.1 148826470 5226086 complement(1509318..1511057) 1 NC_009566.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein 1511057 dipZ 5226086 dipZ Haemophilus influenzae PittEE thiol:disulfide interchange protein YP_001291223.1 1509318 R 374930 CDS YP_001291224.1 148826471 5226087 1511249..1511959 1 NC_009566.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; two-component response regulator 1511959 5226087 CGSHiEE_07610 Haemophilus influenzae PittEE two-component response regulator YP_001291224.1 1511249 D 374930 CDS YP_001291225.1 148826472 5226088 1512359..1513729 1 NC_009566.1 COG1115 Na+/alanine symporter; putative Na+/alanine symporter 1513729 5226088 CGSHiEE_07615 Haemophilus influenzae PittEE putative Na+/alanine symporter YP_001291225.1 1512359 D 374930 CDS YP_001291226.1 148826473 5226089 complement(1513788..1514525) 1 NC_009566.1 COG1636 Uncharacterized protein conserved in bacteria; hypothetical protein 1514525 5226089 CGSHiEE_07620 Haemophilus influenzae PittEE hypothetical protein YP_001291226.1 1513788 R 374930 CDS YP_001291227.1 148826474 5226090 complement(1514576..1515547) 1 NC_009566.1 COG0142 Geranylgeranyl pyrophosphate synthase; octaprenyl-diphosphate synthase 1515547 5226090 CGSHiEE_07625 Haemophilus influenzae PittEE octaprenyl-diphosphate synthase YP_001291227.1 1514576 R 374930 CDS YP_001291228.1 148826475 5226091 1515778..1516089 1 NC_009566.1 COG0261 Ribosomal protein L21; 50S ribosomal protein L21 1516089 rplU 5226091 rplU Haemophilus influenzae PittEE 50S ribosomal protein L21 YP_001291228.1 1515778 D 374930 CDS YP_001291229.1 148826476 5226092 1516110..1516367 1 NC_009566.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1516367 rpmA 5226092 rpmA Haemophilus influenzae PittEE 50S ribosomal protein L27 YP_001291229.1 1516110 D 374930 CDS YP_001291230.1 148826477 5225470 1516448..1517344 1 NC_009566.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; 50S ribosomal protein L27 1517344 rpmA 5225470 rpmA Haemophilus influenzae PittEE 50S ribosomal protein L27 YP_001291230.1 1516448 D 374930 CDS YP_001291231.1 148826478 5225471 1517397..1518608 1 NC_009566.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1518608 obgE 5225471 obgE Haemophilus influenzae PittEE GTPase ObgE YP_001291231.1 1517397 D 374930 CDS YP_001291232.1 148826479 5225472 complement(1518678..1519100) 1 NC_009566.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1519100 ndk 5225472 ndk Haemophilus influenzae PittEE nucleoside diphosphate kinase YP_001291232.1 1518678 R 374930 CDS YP_001291233.1 148826480 5225473 complement(1519110..1520414) 1 NC_009566.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase B 1520414 5225473 CGSHiEE_07655 Haemophilus influenzae PittEE aminopeptidase B YP_001291233.1 1519110 R 374930 CDS YP_001291234.1 148826481 5225474 1520557..1521783 1 NC_009566.1 COG3307 Lipid A core - O-antigen ligase and related enzymes; hypothetical protein 1521783 5225474 CGSHiEE_07660 Haemophilus influenzae PittEE hypothetical protein YP_001291234.1 1520557 D 374930 CDS YP_001291235.1 148826482 5225475 complement(1521819..1522823) 1 NC_009566.1 COG1088 dTDP-D-glucose 4,6-dehydratase; dTDP-glucose 46-dehydratase 1522823 5225475 CGSHiEE_07665 Haemophilus influenzae PittEE dTDP-glucose 46-dehydratase YP_001291235.1 1521819 R 374930 CDS YP_001291236.1 148826483 5225476 complement(1522895..1524313) 1 NC_009566.1 undecaprenyl-phosphate galactosephosphotransferase 1524313 5225476 CGSHiEE_07670 Haemophilus influenzae PittEE undecaprenyl-phosphate galactosephosphotransferase YP_001291236.1 1522895 R 374930 CDS YP_001291237.1 148826484 5225477 complement(1524306..1525184) 1 NC_009566.1 COG2148 Sugar transferases involved in lipopolysaccharide synthesis; N-acetylneuraminic acid synthase-like protein 1525184 5225477 CGSHiEE_07675 Haemophilus influenzae PittEE N-acetylneuraminic acid synthase-like protein YP_001291237.1 1524306 R 374930 CDS YP_001291238.1 148826485 5225875 complement(1525326..1526159) 1 NC_009566.1 putative polysaccharide polymerase 1526159 5225875 CGSHiEE_07680 Haemophilus influenzae PittEE putative polysaccharide polymerase YP_001291238.1 1525326 R 374930 CDS YP_001291239.1 148826486 5225876 complement(1526198..1526338) 1 NC_009566.1 COG3307 Lipid A core - O-antigen ligase and related enzymes; hypothetical protein 1526338 5225876 CGSHiEE_07685 Haemophilus influenzae PittEE hypothetical protein YP_001291239.1 1526198 R 374930 CDS YP_001291240.1 148826487 5225877 complement(1526338..1527222) 1 NC_009566.1 COG1216 Predicted glycosyltransferases; hypothetical protein 1527222 5225877 CGSHiEE_07690 Haemophilus influenzae PittEE hypothetical protein YP_001291240.1 1526338 R 374930 CDS YP_001291241.1 148826488 5225878 complement(1527227..1527979) 1 NC_009566.1 COG0463 Glycosyltransferases involved in cell wall biogenesis; hypothetical protein 1527979 5225878 CGSHiEE_07695 Haemophilus influenzae PittEE hypothetical protein YP_001291241.1 1527227 R 374930 CDS YP_001291242.1 148826489 5225879 complement(1527960..1529177) 1 NC_009566.1 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; lipopolysaccharide biosynthesis protein 1529177 5225879 CGSHiEE_07700 Haemophilus influenzae PittEE lipopolysaccharide biosynthesis protein YP_001291242.1 1527960 R 374930 CDS YP_001291243.1 148826490 5225880 1532072..1533028 1 NC_009566.1 COG0174 Glutamine synthetase; CMP-neu5Ac--lipooligosaccharide alpha 2-3 sialyltransferase 1533028 5225880 CGSHiEE_07715 Haemophilus influenzae PittEE CMP-neu5Ac--lipooligosaccharide alpha 2-3 sialyltransferase YP_001291243.1 1532072 D 374930 CDS YP_001291244.1 148826491 5225881 1533160..1535010 1 NC_009566.1 COG1217 Predicted membrane GTPase involved in stress response; aminopeptidase B 1535010 5225881 CGSHiEE_07720 Haemophilus influenzae PittEE aminopeptidase B YP_001291244.1 1533160 D 374930 CDS YP_001291245.1 148826492 5225938 complement(1535098..1535730) 1 NC_009566.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 1535730 5225938 CGSHiEE_07725 Haemophilus influenzae PittEE pyridoxamine 5'-phosphate oxidase YP_001291245.1 1535098 R 374930 CDS YP_001291246.1 148826493 5225939 1535923..1536630 1 NC_009566.1 COG1738 Uncharacterized conserved protein; hypothetical protein 1536630 5225939 CGSHiEE_07730 Haemophilus influenzae PittEE hypothetical protein YP_001291246.1 1535923 D 374930 CDS YP_001291247.1 148826494 5225940 1536822..1539170 1 NC_009566.1 COG0557 Exoribonuclease R; hypothetical protein 1539170 5225940 CGSHiEE_07735 Haemophilus influenzae PittEE hypothetical protein YP_001291247.1 1536822 D 374930 CDS YP_001291248.1 148826495 5225941 1539226..1539966 1 NC_009566.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 1539966 5225941 CGSHiEE_07740 Haemophilus influenzae PittEE 23S rRNA (guanosine-2'-O-)-methyltransferase YP_001291248.1 1539226 D 374930 CDS YP_001291249.1 148826496 5225942 complement(1540004..1542574) 1 NC_009566.1 COG0542 ATPases with chaperone activity, ATP-binding subunit; ATP-dependent chaperone ClpB 1542574 5225942 CGSHiEE_07745 Haemophilus influenzae PittEE ATP-dependent chaperone ClpB YP_001291249.1 1540004 R 374930 CDS YP_001291250.1 148826497 5225943 complement(1542702..1543265) 1 NC_009566.1 COG0212 5-formyltetrahydrofolate cyclo-ligase; 5-formyltetrahydrofolate cyclo-ligase 1543265 5225943 CGSHiEE_07750 Haemophilus influenzae PittEE 5-formyltetrahydrofolate cyclo-ligase YP_001291250.1 1542702 R 374930 CDS YP_001291251.1 148826498 5225944 complement(1543583..1543885) 1 NC_009566.1 COG3027 Uncharacterized protein conserved in bacteria; hypothetical protein 1543885 5225944 CGSHiEE_07755 Haemophilus influenzae PittEE hypothetical protein YP_001291251.1 1543583 R 374930 CDS YP_001291252.1 148826499 5225945 1544034..1546826 1 NC_009566.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 1546826 5225945 CGSHiEE_07760 Haemophilus influenzae PittEE DNA polymerase I YP_001291252.1 1544034 D 374930 CDS YP_001291253.1 148826500 5225533 1546841..1547047 1 NC_009566.1 COG3681 Uncharacterized conserved protein; hypothetical protein 1547047 5225533 CGSHiEE_07765 Haemophilus influenzae PittEE hypothetical protein YP_001291253.1 1546841 D 374930 CDS YP_001291254.1 148826501 5225534 complement(1547179..1547940) 1 NC_009566.1 COG0748 Putative heme iron utilization protein; putative heme iron utilization protein 1547940 5225534 CGSHiEE_07770 Haemophilus influenzae PittEE putative heme iron utilization protein YP_001291254.1 1547179 R 374930 CDS YP_001291255.1 148826502 5225535 complement(1548116..1549759) 1 NC_009566.1 COG0747 ABC-type dipeptide transport system, periplasmic component; heme-binding lipoprotein 1549759 5225535 CGSHiEE_07775 Haemophilus influenzae PittEE heme-binding lipoprotein YP_001291255.1 1548116 R 374930 CDS YP_001291256.1 148826503 5225536 complement(1551290..1551805) 1 NC_009566.1 molybdopterin-guanine dinucleotide biosynthesis protein B 1551805 5225536 CGSHiEE_07790 Haemophilus influenzae PittEE molybdopterin-guanine dinucleotide biosynthesis protein B YP_001291256.1 1551290 R 374930 CDS YP_001291258.1 148826505 5225538 complement(1552230..1552664) 1 NC_009566.1 COG3086 Positive regulator of sigma E activity; positive regulator of sigma E 1552664 5225538 CGSHiEE_07800 Haemophilus influenzae PittEE positive regulator of sigma E YP_001291258.1 1552230 R 374930 CDS YP_001291259.1 148826506 5225539 complement(1552658..1553431) 1 NC_009566.1 COG0500 SAM-dependent methyltransferases; DNA polymerase I 1553431 5225539 CGSHiEE_07805 Haemophilus influenzae PittEE DNA polymerase I YP_001291259.1 1552658 R 374930 CDS YP_001291260.1 148826507 5226005 complement(1553413..1554504) 1 NC_009566.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 1554504 5226005 CGSHiEE_07810 Haemophilus influenzae PittEE tRNA (uracil-5-)-methyltransferase YP_001291260.1 1553413 R 374930 CDS YP_001291261.1 148826508 5226006 complement(1554648..1554983) 1 NC_009566.1 COG3085 Uncharacterized protein conserved in bacteria; hypothetical protein 1554983 5226006 CGSHiEE_07815 Haemophilus influenzae PittEE hypothetical protein YP_001291261.1 1554648 R 374930 CDS YP_001291262.1 148826509 5226007 complement(1555045..1555662) 1 NC_009566.1 COG0526 Thiol-disulfide isomerase and thioredoxins; thiol:disulfide interchange protein DsbA 1555662 5226007 CGSHiEE_07820 Haemophilus influenzae PittEE thiol:disulfide interchange protein DsbA YP_001291262.1 1555045 R 374930 CDS YP_001291263.1 148826510 5226008 complement(1555673..1555939) 1 NC_009566.1 COG3084 Uncharacterized protein conserved in bacteria; hypothetical protein 1555939 5226008 CGSHiEE_07825 Haemophilus influenzae PittEE hypothetical protein YP_001291263.1 1555673 R 374930 CDS YP_001291264.1 148826511 5226009 1556060..1556587 1 NC_009566.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA 1556587 mobA 5226009 mobA Haemophilus influenzae PittEE molybdopterin-guanine dinucleotide biosynthesis protein MobA YP_001291264.1 1556060 D 374930 CDS YP_001291265.1 148826512 5226010 complement(1556725..1557717) 1 NC_009566.1 COG0402 Cytosine deaminase and related metal-dependent hydrolases; hypothetical protein 1557717 5226010 CGSHiEE_07835 Haemophilus influenzae PittEE hypothetical protein YP_001291265.1 1556725 R 374930 CDS YP_001291266.1 148826513 5226011 complement(1559667..1559885) 1 NC_009566.1 COG3082 Uncharacterized protein conserved in bacteria; hypothetical protein 1559885 5226011 CGSHiEE_07850 Haemophilus influenzae PittEE hypothetical protein YP_001291266.1 1559667 R 374930 CDS YP_001291267.1 148826514 5226106 1560012..1561028 1 NC_009566.1 COG3081 Nucleoid-associated protein; nucleoid-associated protein NdpA 1561028 5226106 CGSHiEE_07855 Haemophilus influenzae PittEE nucleoid-associated protein NdpA YP_001291267.1 1560012 D 374930 CDS YP_001291268.1 148826515 5226107 1561094..1561507 1 NC_009566.1 COG2913 Small protein A (tmRNA-binding); small protein A 1561507 5226107 CGSHiEE_07860 Haemophilus influenzae PittEE small protein A YP_001291268.1 1561094 D 374930 CDS YP_001291269.1 148826516 5226108 1561558..1562241 1 NC_009566.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; nucleoid-associated protein NdpA 1562241 5226108 CGSHiEE_07865 Haemophilus influenzae PittEE nucleoid-associated protein NdpA YP_001291269.1 1561558 D 374930 CDS YP_001291270.1 148826517 5226109 1562337..1562528 1 NC_009566.1 COG0642 Signal transduction histidine kinase; hypothetical protein 1562528 5226109 CGSHiEE_07870 Haemophilus influenzae PittEE hypothetical protein YP_001291270.1 1562337 D 374930 CDS YP_001291271.1 148826518 5226110 1562579..1562683 1 NC_009566.1 COG0642 Signal transduction histidine kinase; hypothetical protein 1562683 5226110 CGSHiEE_07875 Haemophilus influenzae PittEE hypothetical protein YP_001291271.1 1562579 D 374930 CDS YP_001291272.1 148826519 5226111 complement(1562720..1563691) 1 NC_009566.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 1563691 5226111 CGSHiEE_07880 Haemophilus influenzae PittEE lysyl-tRNA synthetase YP_001291272.1 1562720 R 374930 CDS YP_001291273.1 148826520 5226112 1563902..1565701 1 NC_009566.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 1565701 5226112 CGSHiEE_07885 Haemophilus influenzae PittEE fumarate reductase flavoprotein subunit YP_001291273.1 1563902 D 374930 CDS YP_001291274.1 148826521 5226113 1565694..1566464 1 NC_009566.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit 1566464 5226113 CGSHiEE_07890 Haemophilus influenzae PittEE fumarate reductase iron-sulfur subunit YP_001291274.1 1565694 D 374930 CDS YP_001291275.1 148826522 5226285 1566475..1566885 1 NC_009566.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C 1566885 5226285 CGSHiEE_07895 Haemophilus influenzae PittEE fumarate reductase subunit C YP_001291275.1 1566475 D 374930 CDS YP_001291276.1 148826523 5226286 1566898..1567242 1 NC_009566.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 1567242 5226286 CGSHiEE_07900 Haemophilus influenzae PittEE fumarate reductase subunit D YP_001291276.1 1566898 D 374930 CDS YP_001291277.1 148826524 5226287 complement(1567368..1568090) 1 NC_009566.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase 1568090 mtgA 5226287 mtgA Haemophilus influenzae PittEE monofunctional biosynthetic peptidoglycan transglycosylase YP_001291277.1 1567368 R 374930 CDS YP_001291278.1 148826525 5226288 complement(1568077..1568382) 1 NC_009566.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 1568382 5226288 CGSHiEE_07910 Haemophilus influenzae PittEE Trp operon repressor YP_001291278.1 1568077 R 374930 CDS YP_001291279.1 148826526 5226289 complement(1568420..1570201) 1 NC_009566.1 COG1196 Chromosome segregation ATPases; putative soluble lytic murein transglycosylase 1570201 5226289 CGSHiEE_07915 Haemophilus influenzae PittEE putative soluble lytic murein transglycosylase YP_001291279.1 1568420 R 374930 CDS YP_001291280.1 148826527 5226290 complement(1570217..1570513) 1 NC_009566.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; YciI-like protein 1570513 5226290 CGSHiEE_07920 Haemophilus influenzae PittEE YciI-like protein YP_001291280.1 1570217 R 374930 CDS YP_001291281.1 148826528 5226291 complement(1570530..1570994) 1 NC_009566.1 COG1607 Acyl-CoA hydrolase; Trp operon repressor 1570994 5226291 CGSHiEE_07925 Haemophilus influenzae PittEE Trp operon repressor YP_001291281.1 1570530 R 374930 CDS YP_001291282.1 148826529 5226292 complement(1570994..1571551) 1 NC_009566.1 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 1571551 5226292 CGSHiEE_07930 Haemophilus influenzae PittEE intracellular septation protein A YP_001291282.1 1570994 R 374930 CDS YP_001291283.1 148826530 5225677 complement(1571557..1572291) 1 NC_009566.1 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; intracellular septation protein A 1572291 5225677 CGSHiEE_07935 Haemophilus influenzae PittEE intracellular septation protein A YP_001291283.1 1571557 R 374930 CDS YP_001291284.1 148826531 5225678 complement(1572437..1573447) 1 NC_009566.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane component 1573447 mglC 5225678 mglC Haemophilus influenzae PittEE beta-methylgalactoside transporter inner membrane component YP_001291284.1 1572437 R 374930 CDS YP_001291285.1 148826532 5225679 complement(1573464..1574984) 1 NC_009566.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein 1574984 5225679 CGSHiEE_07945 Haemophilus influenzae PittEE galactose/methyl galaxtoside transporter ATP-binding protein YP_001291285.1 1573464 R 374930 CDS YP_001291286.1 148826533 5225680 complement(1575050..1576045) 1 NC_009566.1 COG1879 ABC-type sugar transport system, periplasmic component; galactose ABC transporter periplasmic-binding protein 1576045 5225680 CGSHiEE_07950 Haemophilus influenzae PittEE galactose ABC transporter periplasmic-binding protein YP_001291286.1 1575050 R 374930 CDS YP_001291287.1 148826534 5225681 complement(1576190..1577188) 1 NC_009566.1 COG1609 Transcriptional regulators; methyl-galactoside ABC transporter ATP-binding protein 1577188 5225681 CGSHiEE_07955 Haemophilus influenzae PittEE methyl-galactoside ABC transporter ATP-binding protein YP_001291287.1 1576190 R 374930 CDS YP_001291288.1 148826535 5225682 1577398..1578447 1 NC_009566.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 1578447 5225682 CGSHiEE_07960 Haemophilus influenzae PittEE galactose-1-phosphate uridylyltransferase YP_001291288.1 1577398 D 374930 CDS YP_001291289.1 148826536 5225683 1578524..1579678 1 NC_009566.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 1579678 5225683 CGSHiEE_07965 Haemophilus influenzae PittEE galactokinase YP_001291289.1 1578524 D 374930 CDS YP_001291290.1 148826537 5225684 1579688..1580710 1 NC_009566.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase 1580710 galM 5225684 galM Haemophilus influenzae PittEE aldose 1-epimerase YP_001291290.1 1579688 D 374930 CDS YP_001291291.1 148826538 5225439 1580881..1581429 1 NC_009566.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein 1581429 5225439 CGSHiEE_07975 Haemophilus influenzae PittEE hypothetical protein YP_001291291.1 1580881 D 374930 CDS YP_001291292.1 148826539 5225440 1581441..1582721 1 NC_009566.1 COG0006 Xaa-Pro aminopeptidase; Xaa-Pro aminopeptidase 1582721 5225440 CGSHiEE_07980 Haemophilus influenzae PittEE Xaa-Pro aminopeptidase YP_001291292.1 1581441 D 374930 CDS YP_001291293.1 148826540 5225441 1582835..1583260 1 NC_009566.1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins; universal stress protein A 1583260 5225441 CGSHiEE_07985 Haemophilus influenzae PittEE universal stress protein A YP_001291293.1 1582835 D 374930 CDS YP_001291294.1 148826541 5225442 1583449..1586073 1 NC_009566.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1586073 alaS 5225442 alaS Haemophilus influenzae PittEE alanyl-tRNA synthetase YP_001291294.1 1583449 D 374930 CDS YP_001291295.1 148826542 5225443 1586151..1586342 1 NC_009566.1 affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator 1586342 5225443 CGSHiEE_07995 Haemophilus influenzae PittEE carbon storage regulator YP_001291295.1 1586151 D 374930 CDS YP_001291296.1 148826543 5225444 1586364..1587251 1 NC_009566.1 COG1210 UDP-glucose pyrophosphorylase; carbon storage regulator 1587251 5225444 CGSHiEE_08000 Haemophilus influenzae PittEE carbon storage regulator YP_001291296.1 1586364 D 374930 CDS YP_001291297.1 148826544 5225445 1587386..1588759 1 NC_009566.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 1588759 5225445 CGSHiEE_08005 Haemophilus influenzae PittEE argininosuccinate lyase YP_001291297.1 1587386 D 374930 CDS YP_001291298.1 148826545 5225446 1588904..1589785 1 NC_009566.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 1589785 hslO 5225446 hslO Haemophilus influenzae PittEE Hsp33-like chaperonin YP_001291298.1 1588904 D 374930 CDS YP_001291299.1 148826546 5225519 1589959..1591575 1 NC_009566.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 1591575 5225519 CGSHiEE_08015 Haemophilus influenzae PittEE phosphoenolpyruvate carboxykinase YP_001291299.1 1589959 D 374930 CDS YP_001291300.1 148826547 5225520 1591765..1592286 1 NC_009566.1 COG0233 Ribosome recycling factor; ribosome recycling factor 1592286 frr 5225520 frr Haemophilus influenzae PittEE ribosome recycling factor YP_001291300.1 1591765 D 374930 CDS YP_001291301.1 148826548 5225521 1592396..1593589 1 NC_009566.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1593589 5225521 CGSHiEE_08025 Haemophilus influenzae PittEE 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_001291301.1 1592396 D 374930 CDS YP_001291302.1 148826549 5225522 complement(1593621..1594430) 1 NC_009566.1 COG0730 Predicted permeases; permease 1594430 5225522 CGSHiEE_08030 Haemophilus influenzae PittEE permease YP_001291302.1 1593621 R 374930 CDS YP_001291303.1 148826550 5225523 1594564..1595643 1 NC_009566.1 COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); hypothetical protein 1595643 5225523 CGSHiEE_08035 Haemophilus influenzae PittEE hypothetical protein YP_001291303.1 1594564 D 374930 CDS YP_001291304.1 148826551 5225524 1596107..1596358 1 NC_009566.1 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1596358 5225524 CGSHiEE_08040 Haemophilus influenzae PittEE 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_001291304.1 1596107 D 374930 CDS YP_001291305.1 148826552 5225525 complement(1596486..1596872) 1 NC_009566.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 1596872 rplQ 5225525 rplQ Haemophilus influenzae PittEE 50S ribosomal protein L17 YP_001291305.1 1596486 R 374930 CDS YP_001291306.1 148826553 5225526 complement(1596913..1597899) 1 NC_009566.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 1597899 5225526 CGSHiEE_08050 Haemophilus influenzae PittEE DNA-directed RNA polymerase subunit alpha YP_001291306.1 1596913 R 374930 CDS YP_001291307.1 148826554 5225795 complement(1597931..1598551) 1 NC_009566.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 1598551 rpsD 5225795 rpsD Haemophilus influenzae PittEE 30S ribosomal protein S4 YP_001291307.1 1597931 R 374930 CDS YP_001291308.1 148826555 5225796 complement(1598579..1598968) 1 NC_009566.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 1598968 5225796 CGSHiEE_08060 Haemophilus influenzae PittEE 30S ribosomal protein S11 YP_001291308.1 1598579 R 374930 CDS YP_001291309.1 148826556 5225797 complement(1598984..1599340) 1 NC_009566.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 1599340 rpsM 5225797 rpsM Haemophilus influenzae PittEE 30S ribosomal protein S13 YP_001291309.1 1598984 R 374930 CDS YP_001291310.1 148826557 5225798 complement(1599480..1599593) 1 NC_009566.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 1599593 rpmJ 5225798 rpmJ Haemophilus influenzae PittEE 50S ribosomal protein L36 YP_001291310.1 1599480 R 374930 CDS YP_001291311.1 148826558 5225799 complement(1599622..1600947) 1 NC_009566.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 1600947 secY 5225799 secY Haemophilus influenzae PittEE preprotein translocase subunit SecY YP_001291311.1 1599622 R 374930 CDS YP_001291312.1 148826559 5225800 complement(1600955..1601389) 1 NC_009566.1 late assembly protein; 50S ribosomal protein L15 1601389 rplO 5225800 rplO Haemophilus influenzae PittEE 50S ribosomal protein L15 YP_001291312.1 1600955 R 374930 CDS YP_001291313.1 148826560 5225801 complement(1601393..1601572) 1 NC_009566.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 1601572 rpmD 5225801 rpmD Haemophilus influenzae PittEE 50S ribosomal protein L30 YP_001291313.1 1601393 R 374930 CDS YP_001291314.1 148826561 5225802 complement(1601579..1602079) 1 NC_009566.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 1602079 rpsE 5225802 rpsE Haemophilus influenzae PittEE 30S ribosomal protein S5 YP_001291314.1 1601579 R 374930 CDS YP_001291315.1 148826562 5225837 complement(1602094..1602447) 1 NC_009566.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 1602447 rplR 5225837 rplR Haemophilus influenzae PittEE 50S ribosomal protein L18 YP_001291315.1 1602094 R 374930 CDS YP_001291316.1 148826563 5225838 complement(1602461..1602994) 1 NC_009566.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 1602994 rplF 5225838 rplF Haemophilus influenzae PittEE 50S ribosomal protein L6 YP_001291316.1 1602461 R 374930 CDS YP_001291317.1 148826564 5225839 complement(1603010..1603402) 1 NC_009566.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 1603402 rpsH 5225839 rpsH Haemophilus influenzae PittEE 30S ribosomal protein S8 YP_001291317.1 1603010 R 374930 CDS YP_001291318.1 148826565 5225840 complement(1603356..1603745) 1 NC_009566.1 COG0199 Ribosomal protein S14; 30S ribosomal protein S14 1603745 rpsN 5225840 rpsN Haemophilus influenzae PittEE 30S ribosomal protein S14 YP_001291318.1 1603356 R 374930 CDS YP_001291319.1 148826566 5225841 complement(1603757..1604296) 1 NC_009566.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 1604296 rplE 5225841 rplE Haemophilus influenzae PittEE 50S ribosomal protein L5 YP_001291319.1 1603757 R 374930 CDS YP_001291320.1 148826567 5225842 complement(1604314..1604625) 1 NC_009566.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 1604625 rplX 5225842 rplX Haemophilus influenzae PittEE 50S ribosomal protein L24 YP_001291320.1 1604314 R 374930 CDS YP_001291321.1 148826568 5225843 complement(1604636..1605007) 1 NC_009566.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 1605007 rplN 5225843 rplN Haemophilus influenzae PittEE 50S ribosomal protein L14 YP_001291321.1 1604636 R 374930 CDS YP_001291322.1 148826569 5225844 complement(1605240..1605497) 1 NC_009566.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 1605497 rpsQ 5225844 rpsQ Haemophilus influenzae PittEE 30S ribosomal protein S17 YP_001291322.1 1605240 R 374930 CDS YP_001291323.1 148826570 5225845 complement(1605497..1605688) 1 NC_009566.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 1605688 5225845 CGSHiEE_08135 Haemophilus influenzae PittEE 50S ribosomal protein L29 YP_001291323.1 1605497 R 374930 CDS YP_001291324.1 148826571 5225906 complement(1605688..1606098) 1 NC_009566.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 1606098 rplP 5225906 rplP Haemophilus influenzae PittEE 50S ribosomal protein L16 YP_001291324.1 1605688 R 374930 CDS YP_001291325.1 148826572 5225907 complement(1606112..1606819) 1 NC_009566.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 1606819 rpsC 5225907 rpsC Haemophilus influenzae PittEE 30S ribosomal protein S3 YP_001291325.1 1606112 R 374930 CDS YP_001291326.1 148826573 5225908 complement(1606837..1607169) 1 NC_009566.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 1607169 rplV 5225908 rplV Haemophilus influenzae PittEE 50S ribosomal protein L22 YP_001291326.1 1606837 R 374930 CDS YP_001291327.1 148826574 5225909 complement(1607181..1607456) 1 NC_009566.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 1607456 rpsS 5225909 rpsS Haemophilus influenzae PittEE 30S ribosomal protein S19 YP_001291327.1 1607181 R 374930 CDS YP_001291328.1 148826575 5225910 complement(1607482..1608303) 1 NC_009566.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 1608303 rplB 5225910 rplB Haemophilus influenzae PittEE 50S ribosomal protein L2 YP_001291328.1 1607482 R 374930 CDS YP_001291329.1 148826576 5225911 complement(1608290..1608619) 1 NC_009566.1 COG0089 Ribosomal protein L23; 50S ribosomal protein L23 1608619 rplW 5225911 rplW Haemophilus influenzae PittEE 50S ribosomal protein L23 YP_001291329.1 1608290 R 374930 CDS YP_001291330.1 148826577 5225912 complement(1608616..1609218) 1 NC_009566.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 1609218 rplD 5225912 rplD Haemophilus influenzae PittEE 50S ribosomal protein L4 YP_001291330.1 1608616 R 374930 CDS YP_001291331.1 148826578 5225913 complement(1609876..1610187) 1 NC_009566.1 COG0051 Ribosomal protein S10; 50S ribosomal protein L3 1610187 rplC 5225913 rplC Haemophilus influenzae PittEE 50S ribosomal protein L3 YP_001291331.1 1609876 R 374930 CDS YP_001291332.1 148826579 5226022 complement(1610461..1612038) 1 NC_009566.1 COG1070 Sugar (pentulose and hexulose) kinases; autoinducer-2 (AI-2) kinase 1612038 5226022 CGSHiEE_08190 Haemophilus influenzae PittEE autoinducer-2 (AI-2) kinase YP_001291332.1 1610461 R 374930 CDS YP_001291333.1 148826580 5226023 complement(1612081..1613046) 1 NC_009566.1 COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain; hypothetical protein 1613046 5226023 CGSHiEE_08195 Haemophilus influenzae PittEE hypothetical protein YP_001291333.1 1612081 R 374930 CDS YP_001291334.1 148826581 5226024 1614802..1615782 1 NC_009566.1 COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; hypothetical protein 1615782 5226024 CGSHiEE_08210 Haemophilus influenzae PittEE hypothetical protein YP_001291334.1 1614802 D 374930 CDS YP_001291335.1 148826582 5226025 1615826..1616830 1 NC_009566.1 COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; hypothetical protein 1616830 5226025 CGSHiEE_08215 Haemophilus influenzae PittEE hypothetical protein YP_001291335.1 1615826 D 374930 CDS YP_001291336.1 148826583 5226026 1616866..1617882 1 NC_009566.1 COG1879 ABC-type sugar transport system, periplasmic component; autoinducer-2 (AI-2) kinase 1617882 5226026 CGSHiEE_08220 Haemophilus influenzae PittEE autoinducer-2 (AI-2) kinase YP_001291336.1 1616866 D 374930 CDS YP_001291337.1 148826584 5226027 1617898..1618782 1 NC_009566.1 COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes; aldolase 1618782 5226027 CGSHiEE_08225 Haemophilus influenzae PittEE aldolase YP_001291337.1 1617898 D 374930 CDS YP_001291338.1 148826585 5226028 1618847..1619140 1 NC_009566.1 COG1359 Uncharacterized conserved protein; autoinducer-2 (AI-2) modifying protein LsrG 1619140 5226028 CGSHiEE_08230 Haemophilus influenzae PittEE autoinducer-2 (AI-2) modifying protein LsrG YP_001291338.1 1618847 D 374930 CDS YP_001291339.1 148826586 5226029 1619149..1619841 1 NC_009566.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 1619841 5226029 CGSHiEE_08235 Haemophilus influenzae PittEE ribulose-phosphate 3-epimerase YP_001291339.1 1619149 D 374930 CDS YP_001291340.1 148826587 5224685 complement(1619920..1620849) 1 NC_009566.1 putative ABC transporter, membrane protein; cell division protein FtsX 1620849 ftsX 5224685 ftsX Haemophilus influenzae PittEE cell division protein FtsX YP_001291340.1 1619920 R 374930 CDS YP_001291341.1 148826588 5224686 complement(1620859..1621515) 1 NC_009566.1 COG2884 Predicted ATPase involved in cell division; cell division ATP-binding protein 1621515 5224686 CGSHiEE_08245 Haemophilus influenzae PittEE cell division ATP-binding protein YP_001291341.1 1620859 R 374930 CDS YP_001291342.1 148826589 5224687 complement(1621534..1622736) 1 NC_009566.1 COG0552 Signal recognition particle GTPase; cell division protein FtsY 1622736 5224687 CGSHiEE_08250 Haemophilus influenzae PittEE cell division protein FtsY YP_001291342.1 1621534 R 374930 CDS YP_001291343.1 148826590 5224688 1622833..1623414 1 NC_009566.1 COG0742 N6-adenine-specific methylase; hypothetical protein 1623414 5224688 CGSHiEE_08255 Haemophilus influenzae PittEE hypothetical protein YP_001291343.1 1622833 D 374930 CDS YP_001291344.1 148826591 5224689 1623425..1623907 1 NC_009566.1 COG0219 Predicted rRNA methylase (SpoU class); putative RNA methyltransferase 1623907 5224689 CGSHiEE_08260 Haemophilus influenzae PittEE putative RNA methyltransferase YP_001291344.1 1623425 D 374930 CDS YP_001291345.1 148826592 5224690 complement(1623955..1624791) 1 NC_009566.1 COG3306 Glycosyltransferase involved in LPS biosynthesis; membrane component of ABC transporter FtsEX 1624791 ftsX 5224690 ftsX Haemophilus influenzae PittEE membrane component of ABC transporter FtsEX YP_001291345.1 1623955 R 374930 CDS YP_001291346.1 148826593 5224691 complement(1624818..1625465) 1 NC_009566.1 DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase 1625465 ribB 5224691 ribB Haemophilus influenzae PittEE 3,4-dihydroxy-2-butanone 4-phosphate synthase YP_001291346.1 1624818 R 374930 CDS YP_001291347.1 148826594 5224692 1626947..1627627 1 NC_009566.1 COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases; nicotinamide-nucleotide adenylyltransferase 1627627 5224692 CGSHiEE_08285 Haemophilus influenzae PittEE nicotinamide-nucleotide adenylyltransferase YP_001291347.1 1626947 D 374930 CDS YP_001291348.1 148826595 5225555 complement(1628238..1629311) 1 NC_009566.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 1629311 mltC 5225555 mltC Haemophilus influenzae PittEE murein transglycosylase C YP_001291348.1 1628238 R 374930 CDS YP_001291349.1 148826596 5225556 complement(1629326..1629598) 1 NC_009566.1 COG2924 Fe-S cluster protector protein; hypothetical protein 1629598 5225556 CGSHiEE_08295 Haemophilus influenzae PittEE hypothetical protein YP_001291349.1 1629326 R 374930 CDS YP_001291350.1 148826597 5225557 complement(1629576..1630712) 1 NC_009566.1 COG1194 A/G-specific DNA glycosylase; hypothetical protein 1630712 5225557 CGSHiEE_08300 Haemophilus influenzae PittEE hypothetical protein YP_001291350.1 1629576 R 374930 CDS YP_001291351.1 148826598 5225558 1630889..1631101 1 NC_009566.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1631101 rpmE 5225558 rpmE Haemophilus influenzae PittEE 50S ribosomal protein L31 YP_001291351.1 1630889 D 374930 CDS YP_001291352.1 148826599 5225559 complement(1631179..1631862) 1 NC_009566.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 1631862 5225559 CGSHiEE_08310 Haemophilus influenzae PittEE phosphoglyceromutase YP_001291352.1 1631179 R 374930 CDS YP_001291353.1 148826600 5225560 1633269..1634111 1 NC_009566.1 COG2861 Uncharacterized protein conserved in bacteria; hypothetical protein 1634111 5225560 CGSHiEE_08325 Haemophilus influenzae PittEE hypothetical protein YP_001291353.1 1633269 D 374930 CDS YP_001291354.1 148826601 5225561 complement(1634172..1634915) 1 NC_009566.1 50S ribosomal protein L31 1634915 rpmE 5225561 rpmE Haemophilus influenzae PittEE 50S ribosomal protein L31 YP_001291354.1 1634172 R 374930 CDS YP_001291355.1 148826602 5225562 complement(1634929..1635186) 1 NC_009566.1 COG3306 Glycosyltransferase involved in LPS biosynthesis; hypothetical protein 1635186 5225562 CGSHiEE_08335 Haemophilus influenzae PittEE hypothetical protein YP_001291355.1 1634929 R 374930 CDS YP_001291356.1 148826603 5225980 complement(1635446..1639339) 1 NC_009566.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 1639339 5225980 CGSHiEE_08340 Haemophilus influenzae PittEE phosphoribosylformylglycinamidine synthase YP_001291356.1 1635446 R 374930 CDS YP_001291357.1 148826604 5225981 1639745..1640071 1 NC_009566.1 COG3477 Predicted periplasmic/secreted protein; hypothetical protein 1640071 5225981 CGSHiEE_08345 Haemophilus influenzae PittEE hypothetical protein YP_001291357.1 1639745 D 374930 CDS YP_001291358.1 148826605 5225982 1640125..1640622 1 NC_009566.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1640622 tpx 5225982 tpx Haemophilus influenzae PittEE thiol peroxidase YP_001291358.1 1640125 D 374930 CDS YP_001291359.1 148826606 5225983 complement(1640842..1641666) 1 NC_009566.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 1641666 dapF 5225983 dapF Haemophilus influenzae PittEE diaminopimelate epimerase YP_001291359.1 1640842 R 374930 CDS YP_001291360.1 148826607 5225984 complement(1641809..1642432) 1 NC_009566.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 1642432 5225984 CGSHiEE_08360 Haemophilus influenzae PittEE LexA repressor YP_001291360.1 1641809 R 374930 CDS YP_001291361.1 148826608 5225985 1642686..1645118 1 NC_009566.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 1645118 5225985 CGSHiEE_08365 Haemophilus influenzae PittEE glycerol-3-phosphate acyltransferase YP_001291361.1 1642686 D 374930 CDS YP_001291362.1 148826609 5225986 complement(1645198..1646532) 1 NC_009566.1 COG1252 NADH dehydrogenase, FAD-containing subunit; glycerol-3-phosphate acyltransferase 1646532 5225986 CGSHiEE_08370 Haemophilus influenzae PittEE glycerol-3-phosphate acyltransferase YP_001291362.1 1645198 R 374930 CDS YP_001291363.1 148826610 5225987 complement(1646737..1648059) 1 NC_009566.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 1648059 5225987 CGSHiEE_08375 Haemophilus influenzae PittEE anaerobic C4-dicarboxylate transporter YP_001291363.1 1646737 R 374930 CDS YP_001291364.1 148826611 5225988 complement(1648217..1649266) 1 NC_009566.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II 1649266 ansB 5225988 ansB Haemophilus influenzae PittEE L-asparaginase II YP_001291364.1 1648217 R 374930 CDS YP_001291365.1 148826612 5225969 1649492..1649938 1 NC_009566.1 COG0607 Rhodanese-related sulfurtransferase; L-asparaginase II 1649938 ansB 5225969 ansB Haemophilus influenzae PittEE L-asparaginase II YP_001291365.1 1649492 D 374930 CDS YP_001291366.1 148826613 5225970 1649952..1650461 1 NC_009566.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 1650461 5225970 CGSHiEE_08390 Haemophilus influenzae PittEE preprotein translocase subunit SecB YP_001291366.1 1649952 D 374930 CDS YP_001291367.1 148826614 5225971 complement(1650528..1650842) 1 NC_009566.1 hypothetical protein 1650842 5225971 CGSHiEE_08395 Haemophilus influenzae PittEE hypothetical protein YP_001291367.1 1650528 R 374930 CDS YP_001291369.1 148826616 5225973 complement(1651006..1652658) 1 NC_009566.1 COG1109 Phosphomannomutase; export protein SecB 1652658 5225973 CGSHiEE_08405 Haemophilus influenzae PittEE export protein SecB YP_001291369.1 1651006 R 374930 CDS YP_001291370.1 148826617 5225974 complement(1656417..1657958) 1 NC_009566.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 1657958 5225974 CGSHiEE_08420 Haemophilus influenzae PittEE threonine dehydratase YP_001291370.1 1656417 R 374930 CDS YP_001291371.1 148826618 5225975 complement(1658039..1659877) 1 NC_009566.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 1659877 5225975 CGSHiEE_08425 Haemophilus influenzae PittEE dihydroxy-acid dehydratase YP_001291371.1 1658039 R 374930 CDS YP_001291372.1 148826619 5225976 complement(1659919..1660716) 1 NC_009566.1 COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; acetohydroxy acid synthase II 1660716 5225976 CGSHiEE_08430 Haemophilus influenzae PittEE acetohydroxy acid synthase II YP_001291372.1 1659919 R 374930 CDS YP_001291373.1 148826620 5225492 1660963..1662489 1 NC_009566.1 dihydroxy-acid dehydratase 1662489 5225492 CGSHiEE_08435 Haemophilus influenzae PittEE dihydroxy-acid dehydratase YP_001291373.1 1660963 D 374930 CDS YP_001291374.1 148826621 5225493 1662491..1662586 1 NC_009566.1 COG0733 Na+-dependent transporters of the SNF family; hypothetical protein 1662586 5225493 CGSHiEE_08440 Haemophilus influenzae PittEE hypothetical protein YP_001291374.1 1662491 D 374930 CDS YP_001291375.1 148826622 5225494 complement(1662719..1663432) 1 NC_009566.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 1663432 5225494 CGSHiEE_08445 Haemophilus influenzae PittEE UDP-2,3-diacylglucosamine hydrolase YP_001291375.1 1662719 R 374930 CDS YP_001291376.1 148826623 5225495 1663518..1664240 1 NC_009566.1 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; 1-acyl-sn-glycerol-3-phosphate acyltransferase 1664240 5225495 CGSHiEE_08450 Haemophilus influenzae PittEE 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_001291376.1 1663518 D 374930 CDS YP_001291377.1 148826624 5225496 1664242..1665651 1 NC_009566.1 COG2132 Putative multicopper oxidases; UDP-2,3-diacylglucosamine hydrolase 1665651 5225496 CGSHiEE_08455 Haemophilus influenzae PittEE UDP-2,3-diacylglucosamine hydrolase YP_001291377.1 1664242 D 374930 CDS YP_001291378.1 148826625 5225497 complement(1668208..1669926) 1 NC_009566.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 1669926 5225497 CGSHiEE_08470 Haemophilus influenzae PittEE prolyl-tRNA synthetase YP_001291378.1 1668208 R 374930 CDS YP_001291379.1 148826626 5225498 complement(1670022..1671869) 1 NC_009566.1 COG0514 Superfamily II DNA helicase; prolyl-tRNA synthetase 1671869 5225498 CGSHiEE_08475 Haemophilus influenzae PittEE prolyl-tRNA synthetase YP_001291379.1 1670022 R 374930 CDS YP_001291380.1 148826627 5225499 complement(1671871..1672176) 1 NC_009566.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 1672176 cyaY 5225499 cyaY Haemophilus influenzae PittEE frataxin-like protein YP_001291380.1 1671871 R 374930 CDS YP_001291381.1 148826628 5225886 1672274..1672390 1 NC_009566.1 COG5567 Predicted small periplasmic lipoprotein; hypothetical protein 1672390 5225886 CGSHiEE_08485 Haemophilus influenzae PittEE hypothetical protein YP_001291381.1 1672274 D 374930 CDS YP_001291382.1 148826629 5225887 1672438..1673790 1 NC_009566.1 COG0019 Diaminopimelate decarboxylase; diaminopimelate decarboxylase 1673790 5225887 CGSHiEE_08490 Haemophilus influenzae PittEE diaminopimelate decarboxylase YP_001291382.1 1672438 D 374930 CDS YP_001291383.1 148826630 5225888 1673892..1674518 1 NC_009566.1 nitrate/nitrite response regulator protein 1674518 5225888 CGSHiEE_08495 Haemophilus influenzae PittEE nitrate/nitrite response regulator protein YP_001291383.1 1673892 D 374930 CDS YP_001291384.1 148826631 5225889 complement(1674580..1675020) 1 NC_009566.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; hypothetical protein 1675020 cyaY 5225889 cyaY Haemophilus influenzae PittEE hypothetical protein YP_001291384.1 1674580 R 374930 CDS YP_001291385.1 148826632 5225890 complement(1675024..1675584) 1 NC_009566.1 COG3078 Uncharacterized protein conserved in bacteria; hypothetical protein 1675584 5225890 CGSHiEE_08505 Haemophilus influenzae PittEE hypothetical protein YP_001291385.1 1675024 R 374930 CDS YP_001291386.1 148826633 5225893 complement(1681925..1683301) 1 NC_009566.1 COG0168 Trk-type K+ transport systems, membrane components; Trk system potassium uptake protein TrkH 1683301 5225893 CGSHiEE_08510 Haemophilus influenzae PittEE Trk system potassium uptake protein TrkH YP_001291386.1 1681925 R 374930 CDS YP_001291387.1 148826634 5225540 complement(1683304..1683936) 1 NC_009566.1 COG1739 Uncharacterized conserved protein; hypothetical protein 1683936 5225540 CGSHiEE_08515 Haemophilus influenzae PittEE hypothetical protein YP_001291387.1 1683304 R 374930 CDS YP_001291388.1 148826635 5225541 1684039..1684278 1 NC_009566.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 1684278 5225541 CGSHiEE_08520 Haemophilus influenzae PittEE sulfur transfer protein SirA YP_001291388.1 1684039 D 374930 CDS YP_001291389.1 148826636 5225542 complement(1684320..1685171) 1 NC_009566.1 putative metalloprotease; heat shock protein HtpX 1685171 5225542 CGSHiEE_08525 Haemophilus influenzae PittEE heat shock protein HtpX YP_001291389.1 1684320 R 374930 CDS YP_001291390.1 148826637 5225543 complement(1685339..1685728) 1 NC_009566.1 COG0251 Putative translation initiation inhibitor, yjgF family; putative translation initiation inhibitor, YjgF family protein 1685728 5225543 CGSHiEE_08530 Haemophilus influenzae PittEE putative translation initiation inhibitor, YjgF family protein YP_001291390.1 1685339 R 374930 CDS YP_001291391.1 148826638 5225544 complement(1685785..1686519) 1 NC_009566.1 COG2853 Surface lipoprotein; heat shock protein HtpX 1686519 5225544 CGSHiEE_08535 Haemophilus influenzae PittEE heat shock protein HtpX YP_001291391.1 1685785 R 374930 CDS YP_001291392.1 148826639 5225545 complement(1686689..1687246) 1 NC_009566.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 1687246 nusG 5225545 nusG Haemophilus influenzae PittEE transcription antitermination protein NusG YP_001291392.1 1686689 R 374930 CDS YP_001291393.1 148826640 5225546 complement(1687248..1687664) 1 NC_009566.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 1687664 secE 5225546 secE Haemophilus influenzae PittEE preprotein translocase subunit SecE YP_001291393.1 1687248 R 374930 CDS YP_001291394.1 148826641 5225547 complement(1687808..1689043) 1 NC_009566.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 1689043 clpX 5225547 clpX Haemophilus influenzae PittEE ATP-dependent protease ATP-binding subunit ClpX YP_001291394.1 1687808 R 374930 CDS YP_001291395.1 148826642 5226240 complement(1689053..1689634) 1 NC_009566.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 1689634 clpP 5226240 clpP Haemophilus influenzae PittEE ATP-dependent Clp protease proteolytic subunit YP_001291395.1 1689053 R 374930 CDS YP_001291396.1 148826643 5226241 complement(1689757..1691055) 1 NC_009566.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 1691055 tig 5226241 tig Haemophilus influenzae PittEE trigger factor YP_001291396.1 1689757 R 374930 CDS YP_001291397.1 148826644 5226242 1691408..1691530 1 NC_009566.1 COG0544 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor); hypothetical protein 1691530 5226242 CGSHiEE_08565 Haemophilus influenzae PittEE hypothetical protein YP_001291397.1 1691408 D 374930 CDS YP_001291398.1 148826645 5226243 complement(1694661..1694969) 1 NC_009566.1 COG3041 Uncharacterized protein conserved in bacteria; hypothetical protein 1694969 5226243 CGSHiEE_08580 Haemophilus influenzae PittEE hypothetical protein YP_001291398.1 1694661 R 374930 CDS YP_001291399.1 148826646 5226244 complement(1694969..1695265) 1 NC_009566.1 hypothetical protein 1695265 5226244 CGSHiEE_08585 Haemophilus influenzae PittEE hypothetical protein YP_001291399.1 1694969 R 374930 CDS YP_001291400.1 148826647 5226245 complement(1695386..1696240) 1 NC_009566.1 COG3077 DNA-damage-inducible protein J; hypothetical protein 1696240 5226245 CGSHiEE_08590 Haemophilus influenzae PittEE hypothetical protein YP_001291400.1 1695386 R 374930 CDS YP_001291401.1 148826648 5226246 complement(1696259..1698118) 1 NC_009566.1 COG3276 Selenocysteine-specific translation elongation factor; selenocysteine-specific elongation factor 1698118 tig 5226246 tig Haemophilus influenzae PittEE selenocysteine-specific elongation factor YP_001291401.1 1696259 R 374930 CDS YP_001291402.1 148826649 5225455 complement(1698115..1699500) 1 NC_009566.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 1699500 5225455 CGSHiEE_08600 Haemophilus influenzae PittEE selenocysteine synthase YP_001291402.1 1698115 R 374930 CDS YP_001291403.1 148826650 5225456 1699911..1700999 1 NC_009566.1 COG1672 Predicted ATPase (AAA+ superfamily); selenocysteine synthase 1700999 5225456 CGSHiEE_08605 Haemophilus influenzae PittEE selenocysteine synthase YP_001291403.1 1699911 D 374930 CDS YP_001291404.1 148826651 5225457 complement(1701389..1703974) 1 NC_009566.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 1703974 5225457 CGSHiEE_08610 Haemophilus influenzae PittEE DNA mismatch repair protein MutS YP_001291404.1 1701389 R 374930 CDS YP_001291405.1 148826652 5225458 complement(1704108..1705325) 1 NC_009566.1 COG0739 Membrane proteins related to metalloendopeptidases; lipoprotein 1705325 5225458 CGSHiEE_08615 Haemophilus influenzae PittEE lipoprotein YP_001291405.1 1704108 R 374930 CDS YP_001291406.1 148826653 5225459 complement(1705349..1705534) 1 NC_009566.1 COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases; hypothetical protein 1705534 5225459 CGSHiEE_08620 Haemophilus influenzae PittEE hypothetical protein YP_001291406.1 1705349 R 374930 CDS YP_001291407.1 148826654 5225460 complement(1705543..1706085) 1 NC_009566.1 COG1238 Predicted membrane protein; DNA mismatch repair protein 1706085 5225460 CGSHiEE_08625 Haemophilus influenzae PittEE DNA mismatch repair protein YP_001291407.1 1705543 R 374930 CDS YP_001291408.1 148826655 5225461 complement(1706132..1706881) 1 NC_009566.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 1706881 surE 5225461 surE Haemophilus influenzae PittEE stationary phase survival protein SurE YP_001291408.1 1706132 R 374930 CDS YP_001291409.1 148826656 5225462 complement(1706891..1707910) 1 NC_009566.1 catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D 1707910 truD 5225462 truD Haemophilus influenzae PittEE tRNA pseudouridine synthase D YP_001291409.1 1706891 R 374930 CDS YP_001291410.1 148826657 5225463 1708019..1708441 1 NC_009566.1 COG3076 Uncharacterized protein conserved in bacteria; hypothetical protein 1708441 5225463 CGSHiEE_08640 Haemophilus influenzae PittEE hypothetical protein YP_001291410.1 1708019 D 374930 CDS YP_001291411.1 148826658 5225668 1708519..1709091 1 NC_009566.1 COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2; FKBP-type peptidyl-prolyl cis-trans isomerase SlyD 1709091 5225668 CGSHiEE_08645 Haemophilus influenzae PittEE FKBP-type peptidyl-prolyl cis-trans isomerase SlyD YP_001291411.1 1708519 D 374930 CDS YP_001291412.1 148826659 5225669 1709242..1710978 1 NC_009566.1 COG0729 Outer membrane protein; hypothetical protein 1710978 5225669 CGSHiEE_08650 Haemophilus influenzae PittEE hypothetical protein YP_001291412.1 1709242 D 374930 CDS YP_001291413.1 148826660 5225670 1710988..1714884 1 NC_009566.1 COG2911 Uncharacterized protein conserved in bacteria; hypothetical protein 1714884 5225670 CGSHiEE_08655 Haemophilus influenzae PittEE hypothetical protein YP_001291413.1 1710988 D 374930 CDS YP_001291414.1 148826661 5225671 1714892..1715869 1 NC_009566.1 COG0248 Exopolyphosphatase; exopolyphosphatase 1715869 5225671 CGSHiEE_08660 Haemophilus influenzae PittEE exopolyphosphatase YP_001291414.1 1714892 D 374930 CDS YP_001291415.1 148826662 5225672 complement(1715982..1716665) 1 NC_009566.1 COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; hypothetical protein 1716665 5225672 CGSHiEE_08665 Haemophilus influenzae PittEE hypothetical protein YP_001291415.1 1715982 R 374930 CDS YP_001291416.1 148826663 5225673 complement(1716844..1717668) 1 NC_009566.1 COG2503 Predicted secreted acid phosphatase; hypothetical protein 1717668 5225673 CGSHiEE_08670 Haemophilus influenzae PittEE hypothetical protein YP_001291416.1 1716844 R 374930 CDS YP_001291417.1 148826664 5225674 complement(1717794..1717979) 1 NC_009566.1 COG0584 Glycerophosphoryl diester phosphodiesterase; glycerophosphodiester phosphodiesterase 1717979 glpQ 5225674 glpQ Haemophilus influenzae PittEE glycerophosphodiester phosphodiesterase YP_001291417.1 1717794 R 374930 CDS YP_001291418.1 148826665 5225675 complement(1718240..1719718) 1 NC_009566.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 1719718 5225675 CGSHiEE_08680 Haemophilus influenzae PittEE ketol-acid reductoisomerase YP_001291418.1 1718240 R 374930 CDS YP_001291419.1 148826666 5225676 complement(1719997..1720062) 1 NC_009566.1 COG0059 Ketol-acid reductoisomerase; hypothetical protein 1720062 5225676 CGSHiEE_08685 Haemophilus influenzae PittEE hypothetical protein YP_001291419.1 1719997 R 374930 CDS YP_001291420.1 148826667 5225577 1720061..1720861 1 NC_009566.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 1720861 5225577 CGSHiEE_08690 Haemophilus influenzae PittEE DNA-binding transcriptional regulator IlvY YP_001291420.1 1720061 D 374930 CDS YP_001291421.1 148826668 5225578 1720893..1721771 1 NC_009566.1 COG2962 Predicted permeases; hypothetical protein 1721771 5225578 CGSHiEE_08695 Haemophilus influenzae PittEE hypothetical protein YP_001291421.1 1720893 D 374930 CDS YP_001291422.1 148826669 5225579 1721772..1722089 1 NC_009566.1 COG0607 Rhodanese-related sulfurtransferase; DNA-binding transcriptional regulator IlvY 1722089 5225579 CGSHiEE_08700 Haemophilus influenzae PittEE DNA-binding transcriptional regulator IlvY YP_001291422.1 1721772 D 374930 CDS YP_001291423.1 148826670 5225580 complement(1722172..1722963) 1 NC_009566.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1722963 tpiA 5225580 tpiA Haemophilus influenzae PittEE triosephosphate isomerase YP_001291423.1 1722172 R 374930 CDS YP_001291424.1 148826671 5225581 1723128..1723568 1 NC_009566.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; triosephosphate isomerase 1723568 tpiA 5225581 tpiA Haemophilus influenzae PittEE triosephosphate isomerase YP_001291424.1 1723128 D 374930 CDS YP_001291425.1 148826672 5225582 1723562..1724449 1 NC_009566.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 1724449 xerC 5225582 xerC Haemophilus influenzae PittEE site-specific tyrosine recombinase XerC YP_001291425.1 1723562 D 374930 CDS YP_001291426.1 148826673 5225583 complement(1724502..1725956) 1 NC_009566.1 COG2195 Di- and tripeptidases; site-specific tyrosine recombinase XerC 1725956 xerC 5225583 xerC Haemophilus influenzae PittEE site-specific tyrosine recombinase XerC YP_001291426.1 1724502 R 374930 CDS YP_001291427.1 148826674 5225584 1726067..1726534 1 NC_009566.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 1726534 5225584 CGSHiEE_08725 Haemophilus influenzae PittEE xanthine-guanine phosphoribosyltransferase YP_001291427.1 1726067 D 374930 CDS YP_001291428.1 148826675 5225585 complement(1726618..1728129) 1 NC_009566.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 1728129 glpK 5225585 glpK Haemophilus influenzae PittEE glycerol kinase YP_001291428.1 1726618 R 374930 CDS YP_001291429.1 148826676 5225803 complement(1729162..1730256) 1 NC_009566.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase 1730256 glpQ 5225803 glpQ Haemophilus influenzae PittEE glycerophosphodiester phosphodiesterase YP_001291429.1 1729162 R 374930 CDS YP_001291430.1 148826677 5225804 complement(1730360..1731802) 1 NC_009566.1 COG2271 Sugar phosphate permease; glycerophosphodiester phosphodiesterase 1731802 glpQ 5225804 glpQ Haemophilus influenzae PittEE glycerophosphodiester phosphodiesterase YP_001291430.1 1730360 R 374930 CDS YP_001291431.1 148826678 5225805 1732092..1733783 1 NC_009566.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 1733783 glpA 5225805 glpA Haemophilus influenzae PittEE sn-glycerol-3-phosphate dehydrogenase subunit A YP_001291431.1 1732092 D 374930 CDS YP_001291432.1 148826679 5225806 1733773..1735071 1 NC_009566.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 1735071 5225806 CGSHiEE_08760 Haemophilus influenzae PittEE anaerobic glycerol-3-phosphate dehydrogenase subunit B YP_001291432.1 1733773 D 374930 CDS YP_001291433.1 148826680 5225807 1735083..1736363 1 NC_009566.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 1736363 glpC 5225807 glpC Haemophilus influenzae PittEE sn-glycerol-3-phosphate dehydrogenase subunit C YP_001291433.1 1735083 D 374930 CDS YP_001291434.1 148826681 5225808 1736679..1737350 1 NC_009566.1 COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components; ferrichrome ABC transporter ATP-binding protein 1737350 5225808 CGSHiEE_08770 Haemophilus influenzae PittEE ferrichrome ABC transporter ATP-binding protein YP_001291434.1 1736679 D 374930 CDS YP_001291435.1 148826682 5225809 1737352..1738236 1 NC_009566.1 sn-glycerol-3-phosphate dehydrogenase subunit C 1738236 glpC 5225809 glpC Haemophilus influenzae PittEE sn-glycerol-3-phosphate dehydrogenase subunit C YP_001291435.1 1737352 D 374930 CDS YP_001291436.1 148826683 5225810 1738223..1738402 1 NC_009566.1 COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component; hypothetical protein 1738402 5225810 CGSHiEE_08780 Haemophilus influenzae PittEE hypothetical protein YP_001291436.1 1738223 D 374930 CDS YP_001291437.1 148826684 5225408 1738230..1740200 1 NC_009566.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 1740200 5225408 CGSHiEE_08785 Haemophilus influenzae PittEE iron-hydroxamate transporter permease subunit YP_001291437.1 1738230 D 374930 CDS YP_001291438.1 148826685 5225409 1740319..1742490 1 NC_009566.1 COG1629 Outer membrane receptor proteins, mostly Fe transport; putative ferric siderophore receptor 1742490 5225409 CGSHiEE_08790 Haemophilus influenzae PittEE putative ferric siderophore receptor YP_001291438.1 1740319 D 374930 CDS YP_001291439.1 148826686 5225410 1742777..1743115 1 NC_009566.1 COG2801 Transposase and inactivated derivatives; iron-hydroxamate transporter permease subunit 1743115 5225410 CGSHiEE_08795 Haemophilus influenzae PittEE iron-hydroxamate transporter permease subunit YP_001291439.1 1742777 D 374930 CDS YP_001291440.1 148826687 5225411 1743365..1743832 1 NC_009566.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 1743832 5225411 CGSHiEE_08800 Haemophilus influenzae PittEE xanthine-guanine phosphoribosyltransferase YP_001291440.1 1743365 D 374930 CDS YP_001291442.1 148826689 5225413 1743955..1744233 1 NC_009566.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB 1744233 ftsB 5225413 ftsB Haemophilus influenzae PittEE cell division protein FtsB YP_001291442.1 1743955 D 374930 CDS YP_001291443.1 148826690 5225414 1744233..1744910 1 NC_009566.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1744910 ispD 5225414 ispD Haemophilus influenzae PittEE 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_001291443.1 1744233 D 374930 CDS YP_001291444.1 148826691 5225415 1744907..1745383 1 NC_009566.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 1745383 ispF 5225415 ispF Haemophilus influenzae PittEE 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_001291444.1 1744907 D 374930 CDS YP_001291445.1 148826692 5225416 complement(1745685..1746119) 1 NC_009566.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 1746119 5225416 CGSHiEE_08825 Haemophilus influenzae PittEE D-tyrosyl-tRNA(Tyr) deacylase YP_001291445.1 1745685 R 374930 CDS YP_001291446.1 148826693 5225500 complement(1746116..1746556) 1 NC_009566.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 1746556 5225500 CGSHiEE_08830 Haemophilus influenzae PittEE flavodoxin YP_001291446.1 1746116 R 374930 CDS YP_001291447.1 148826694 5225501 complement(1746651..1746869) 1 NC_009566.1 COG3074 Uncharacterized protein conserved in bacteria; flavodoxin 1746869 5225501 CGSHiEE_08835 Haemophilus influenzae PittEE flavodoxin YP_001291447.1 1746651 R 374930 CDS YP_001291448.1 148826695 5225502 1748233..1748541 1 NC_009566.1 COG1396 Predicted transcriptional regulators; hypothetical protein 1748541 5225502 CGSHiEE_08850 Haemophilus influenzae PittEE hypothetical protein YP_001291448.1 1748233 D 374930 CDS YP_001291449.1 148826696 5225503 1748529..1748849 1 NC_009566.1 COG3550 Uncharacterized protein related to capsule biosynthesis enzymes; hypothetical protein 1748849 5225503 CGSHiEE_08855 Haemophilus influenzae PittEE hypothetical protein YP_001291449.1 1748529 D 374930 CDS YP_001291450.1 148826697 5225504 1748846..1749877 1 NC_009566.1 COG3550 Uncharacterized protein related to capsule biosynthesis enzymes; hypothetical protein 1749877 5225504 CGSHiEE_08860 Haemophilus influenzae PittEE hypothetical protein YP_001291450.1 1748846 D 374930 CDS YP_001291451.1 148826698 5225505 complement(1749961..1751619) 1 NC_009566.1 COG1132 ABC-type multidrug transport system, ATPase and permease components; ABC transporter ATP-binding protein 1751619 5225505 CGSHiEE_08865 Haemophilus influenzae PittEE ABC transporter ATP-binding protein YP_001291451.1 1749961 R 374930 CDS YP_001291452.1 148826699 5225506 complement(1751612..1753357) 1 NC_009566.1 ABC transporter ATP-binding protein 1753357 5225506 CGSHiEE_08870 Haemophilus influenzae PittEE ABC transporter ATP-binding protein YP_001291452.1 1751612 R 374930 CDS YP_001291453.1 148826700 5225507 complement(1753410..1753574) 1 NC_009566.1 hypothetical protein 1753574 5225507 CGSHiEE_08875 Haemophilus influenzae PittEE hypothetical protein YP_001291453.1 1753410 R 374930 CDS YP_001291454.1 148826701 5225508 1753919..1754041 1 NC_009566.1 hypothetical protein 1754041 5225508 CGSHiEE_08880 Haemophilus influenzae PittEE hypothetical protein YP_001291454.1 1753919 D 374930 CDS YP_001291455.1 148826702 5226312 1753947..1754135 1 NC_009566.1 COG4988 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components; hypothetical protein 1754135 5226312 CGSHiEE_08885 Haemophilus influenzae PittEE hypothetical protein YP_001291455.1 1753947 D 374930 CDS YP_001291456.1 148826703 5226313 1754182..1757136 1 NC_009566.1 COG1629 Outer membrane receptor proteins, mostly Fe transport; hemoglobin-binding protein 1757136 5226313 CGSHiEE_08890 Haemophilus influenzae PittEE hemoglobin-binding protein YP_001291456.1 1754182 D 374930 CDS YP_001291457.1 148826704 5226314 1757406..1757765 1 NC_009566.1 COG4679 Phage-related protein; hypothetical protein 1757765 5226314 CGSHiEE_08895 Haemophilus influenzae PittEE hypothetical protein YP_001291457.1 1757406 D 374930 CDS YP_001291458.1 148826705 5226315 1757758..1758054 1 NC_009566.1 COG1396 Predicted transcriptional regulators; putative HTH-type transcriptional regulator 1758054 5226315 CGSHiEE_08900 Haemophilus influenzae PittEE putative HTH-type transcriptional regulator YP_001291458.1 1757758 D 374930 CDS YP_001291459.1 148826706 5226316 1758171..1760087 1 NC_009566.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains; ABC transporter ATP-binding protein 1760087 5226316 CGSHiEE_08905 Haemophilus influenzae PittEE ABC transporter ATP-binding protein YP_001291459.1 1758171 D 374930 CDS YP_001291460.1 148826707 5226317 1760097..1760633 1 NC_009566.1 COG0551 Zn-finger domain associated with topoisomerase type I; hypothetical protein 1760633 5226317 CGSHiEE_08910 Haemophilus influenzae PittEE hypothetical protein YP_001291460.1 1760097 D 374930 CDS YP_001291461.1 148826708 5226318 1760649..1761200 1 NC_009566.1 COG0009 Putative translation factor (SUA5); fructose 1,6-bisphosphatase II 1761200 glpX 5226318 glpX Haemophilus influenzae PittEE fructose 1,6-bisphosphatase II YP_001291461.1 1760649 D 374930 CDS YP_001291462.1 148826709 5226319 1761204..1762010 1 NC_009566.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 1762010 aroE 5226319 aroE Haemophilus influenzae PittEE shikimate 5-dehydrogenase YP_001291462.1 1761204 D 374930 CDS YP_001291463.1 148826710 5226320 1762022..1762780 1 NC_009566.1 COG0169 Shikimate 5-dehydrogenase; hypothetical protein 1762780 5226320 CGSHiEE_08925 Haemophilus influenzae PittEE hypothetical protein YP_001291463.1 1762022 D 374930 CDS YP_001291464.1 148826711 5224675 1762889..1763452 1 NC_009566.1 COG2818 3-methyladenine DNA glycosylase; DNA-3-methyladenine glycosylase 1763452 5224675 CGSHiEE_08930 Haemophilus influenzae PittEE DNA-3-methyladenine glycosylase YP_001291464.1 1762889 D 374930 CDS YP_001291465.1 148826712 5224676 complement(1763449..1764213) 1 NC_009566.1 COG0463 Glycosyltransferases involved in cell wall biogenesis; shikimate 5-dehydrogenase 1764213 aroE 5224676 aroE Haemophilus influenzae PittEE shikimate 5-dehydrogenase YP_001291465.1 1763449 R 374930 CDS YP_001291466.1 148826713 5224677 1764278..1765558 1 NC_009566.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 1765558 5224677 CGSHiEE_08940 Haemophilus influenzae PittEE 3-deoxy-D-manno-octulosonic-acid transferase YP_001291466.1 1764278 D 374930 CDS YP_001291467.1 148826714 5224678 1765555..1766025 1 NC_009566.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1766025 coaD 5224678 coaD Haemophilus influenzae PittEE phosphopantetheine adenylyltransferase YP_001291467.1 1765555 D 374930 CDS YP_001291468.1 148826715 5224679 1766022..1766234 1 NC_009566.1 COG0669 Phosphopantetheine adenylyltransferase; periplasmic lipoprotein 1766234 5224679 CGSHiEE_08950 Haemophilus influenzae PittEE periplasmic lipoprotein YP_001291468.1 1766022 D 374930 CDS YP_001291469.1 148826716 5224680 1766240..1768255 1 NC_009566.1 COG0210 Superfamily I DNA and RNA helicases; ATP-dependent DNA helicase 1768255 5224680 CGSHiEE_08955 Haemophilus influenzae PittEE ATP-dependent DNA helicase YP_001291469.1 1766240 D 374930 CDS YP_001291470.1 148826717 5224681 complement(1768574..1769245) 1 NC_009566.1 COG0583 Transcriptional regulator; LysR family transcriptional regulator 1769245 5224681 CGSHiEE_08960 Haemophilus influenzae PittEE LysR family transcriptional regulator YP_001291470.1 1768574 R 374930 CDS YP_001291471.1 148826718 5224682 1769359..1769937 1 NC_009566.1 putative NADPH-quinone reductase, modulator of drug activity B 1769937 5224682 CGSHiEE_08965 Haemophilus influenzae PittEE putative NADPH-quinone reductase, modulator of drug activity B YP_001291471.1 1769359 D 374930 CDS YP_001291472.1 148826719 5224683 1769930..1770136 1 NC_009566.1 COG2249 Putative NADPH-quinone reductase (modulator of drug activity B); hypothetical protein 1770136 5224683 CGSHiEE_08970 Haemophilus influenzae PittEE hypothetical protein YP_001291472.1 1769930 D 374930 CDS YP_001291473.1 148826720 5224684 1770215..1770931 1 NC_009566.1 COG1285 Uncharacterized membrane protein; phosphopantetheine adenylyltransferase 1770931 coaD 5224684 coaD Haemophilus influenzae PittEE phosphopantetheine adenylyltransferase YP_001291473.1 1770215 D 374930 CDS YP_001291474.1 148826721 5225954 1771097..1772212 1 NC_009566.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 1772212 5225954 CGSHiEE_08980 Haemophilus influenzae PittEE aspartate-semialdehyde dehydrogenase YP_001291474.1 1771097 D 374930 CDS YP_001291475.1 148826722 5225955 1772267..1773208 1 NC_009566.1 COG2267 Lysophospholipase; lysophospholipase L2 1773208 5225955 CGSHiEE_08985 Haemophilus influenzae PittEE lysophospholipase L2 YP_001291475.1 1772267 D 374930 CDS YP_001291476.1 148826723 5225956 1773363..1774463 1 NC_009566.1 COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit; cytochrome C-like protein 1774463 5225956 CGSHiEE_08990 Haemophilus influenzae PittEE cytochrome C-like protein YP_001291476.1 1773363 D 374930 CDS YP_001291477.1 148826724 5225957 1777674..1777985 1 NC_009566.1 COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family); aspartate-semialdehyde dehydrogenase 1777985 5225957 CGSHiEE_09005 Haemophilus influenzae PittEE aspartate-semialdehyde dehydrogenase YP_001291477.1 1777674 D 374930 CDS YP_001291478.1 148826725 5225958 complement(1778027..1779397) 1 NC_009566.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 1779397 glmU 5225958 glmU Haemophilus influenzae PittEE bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_001291478.1 1778027 R 374930 CDS YP_001291479.1 148826726 5225959 complement(1779556..1779927) 1 NC_009566.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 1779927 rplL 5225959 rplL Haemophilus influenzae PittEE 50S ribosomal protein L7/L12 YP_001291479.1 1779556 R 374930 CDS YP_001291480.1 148826727 5225960 complement(1779982..1780473) 1 NC_009566.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 1780473 rplJ 5225960 rplJ Haemophilus influenzae PittEE 50S ribosomal protein L10 YP_001291480.1 1779982 R 374930 CDS YP_001291481.1 148826728 5225961 complement(1780745..1782115) 1 NC_009566.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1782115 5225961 CGSHiEE_09025 Haemophilus influenzae PittEE adenylosuccinate lyase YP_001291481.1 1780745 R 374930 CDS YP_001291482.1 148826729 5225386 complement(1782138..1782755) 1 NC_009566.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 1782755 5225386 CGSHiEE_09030 Haemophilus influenzae PittEE hypothetical protein YP_001291482.1 1782138 R 374930 CDS YP_001291483.1 148826730 5225387 1782884..1783888 1 NC_009566.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 1783888 5225387 CGSHiEE_09035 Haemophilus influenzae PittEE tryptophanyl-tRNA synthetase YP_001291483.1 1782884 D 374930 CDS YP_001291484.1 148826731 5225388 1783963..1784199 1 NC_009566.1 COG3691 Uncharacterized protein conserved in bacteria; tryptophanyl-tRNA synthetase 1784199 5225388 CGSHiEE_09040 Haemophilus influenzae PittEE tryptophanyl-tRNA synthetase YP_001291484.1 1783963 D 374930 CDS YP_001291485.1 148826732 5225389 complement(1784247..1785230) 1 NC_009566.1 COG0042 tRNA-dihydrouridine synthase; tRNA-dihydrouridine synthase A 1785230 5225389 CGSHiEE_09045 Haemophilus influenzae PittEE tRNA-dihydrouridine synthase A YP_001291485.1 1784247 R 374930 CDS YP_001291486.1 148826733 5225390 complement(1785233..1785409) 1 NC_009566.1 COG0038 Chloride channel protein EriC; chloride channel protein 1785409 5225390 CGSHiEE_09050 Haemophilus influenzae PittEE chloride channel protein YP_001291486.1 1785233 R 374930 CDS YP_001291487.1 148826734 5225391 complement(1785406..1785684) 1 NC_009566.1 COG0038 Chloride channel protein EriC; chloride channel protein 1785684 5225391 CGSHiEE_09055 Haemophilus influenzae PittEE chloride channel protein YP_001291487.1 1785406 R 374930 CDS YP_001291488.1 148826735 5225392 complement(1786210..1787394) 1 NC_009566.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 1787394 5225392 CGSHiEE_09060 Haemophilus influenzae PittEE elongation factor Tu YP_001291488.1 1786210 R 374930 CDS YP_001291489.1 148826736 5225393 1787912..1788004 1 NC_009566.1 COG0050 GTPases - translation elongation factors; hypothetical protein 1788004 5225393 CGSHiEE_09065 Haemophilus influenzae PittEE hypothetical protein YP_001291489.1 1787912 D 374930 CDS YP_001291490.1 148826737 5225394 complement(1789116..1790063) 1 NC_009566.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE 1790063 rseB 5225394 rseB Haemophilus influenzae PittEE periplasmic negative regulator of sigmaE YP_001291490.1 1789116 R 374930 CDS YP_001291491.1 148826738 5225568 complement(1790143..1790730) 1 NC_009566.1 COG3073 Negative regulator of sigma E activity; periplasmic negative regulator of sigmaE 1790730 rseB 5225568 rseB Haemophilus influenzae PittEE periplasmic negative regulator of sigmaE YP_001291491.1 1790143 R 374930 CDS YP_001291492.1 148826739 5225569 complement(1790755..1791324) 1 NC_009566.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 1791324 5225569 CGSHiEE_09090 Haemophilus influenzae PittEE RNA polymerase sigma factor RpoE YP_001291492.1 1790755 R 374930 CDS YP_001291493.1 148826740 5225570 complement(1791423..1791689) 1 NC_009566.1 COG2938 Uncharacterized conserved protein; hypothetical protein 1791689 5225570 CGSHiEE_09095 Haemophilus influenzae PittEE hypothetical protein YP_001291493.1 1791423 R 374930 CDS YP_001291494.1 148826741 5225571 complement(1791780..1792166) 1 NC_009566.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 1792166 mscL 5225571 mscL Haemophilus influenzae PittEE large-conductance mechanosensitive channel YP_001291494.1 1791780 R 374930 CDS YP_001291495.1 148826742 5225572 complement(1792239..1793615) 1 NC_009566.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 1793615 trkA 5225572 trkA Haemophilus influenzae PittEE potassium transporter peripheral membrane component YP_001291495.1 1792239 R 374930 CDS YP_001291496.1 148826743 5225573 complement(1793628..1794983) 1 NC_009566.1 COG0144 tRNA and rRNA cytosine-C5-methylases; potassium transporter peripheral membrane component 1794983 trkA 5225573 trkA Haemophilus influenzae PittEE potassium transporter peripheral membrane component YP_001291496.1 1793628 R 374930 CDS YP_001291497.1 148826744 5225574 complement(1794983..1795939) 1 NC_009566.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 1795939 fmt 5225574 fmt Haemophilus influenzae PittEE methionyl-tRNA formyltransferase YP_001291497.1 1794983 R 374930 CDS YP_001291498.1 148826745 5225575 complement(1796033..1796542) 1 NC_009566.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1796542 def 5225575 def Haemophilus influenzae PittEE peptide deformylase YP_001291498.1 1796033 R 374930 CDS YP_001291499.1 148826746 5225576 complement(1796651..1797145) 1 NC_009566.1 hypothetical protein 1797145 5225576 CGSHiEE_09125 Haemophilus influenzae PittEE hypothetical protein YP_001291499.1 1796651 R 374930 CDS YP_001291500.1 148826747 5226147 complement(1797155..1797616) 1 NC_009566.1 hypothetical protein 1797616 5226147 CGSHiEE_09130 Haemophilus influenzae PittEE hypothetical protein YP_001291500.1 1797155 R 374930 CDS YP_001291501.1 148826748 5226148 complement(1797632..1797913) 1 NC_009566.1 hypothetical protein 1797913 5226148 CGSHiEE_09135 Haemophilus influenzae PittEE hypothetical protein YP_001291501.1 1797632 R 374930 CDS YP_001291503.1 148826750 5226150 complement(1798026..1798289) 1 NC_009566.1 COG0242 N-formylmethionyl-tRNA deformylase; hypothetical protein 1798289 5226150 CGSHiEE_09145 Haemophilus influenzae PittEE hypothetical protein YP_001291503.1 1798026 R 374930 CDS YP_001291504.1 148826751 5224697 complement(1804179..1804715) 1 NC_009566.1 COG3070 Regulator of competence-specific genes; peptide deformylase 1804715 def 5224697 def Haemophilus influenzae PittEE peptide deformylase YP_001291504.1 1804179 R 374930 CDS YP_001291505.1 148826752 5225996 1805205..1806269 1 NC_009566.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1806269 recA 5225996 recA Haemophilus influenzae PittEE recombinase A YP_001291505.1 1805205 D 374930 CDS YP_001291506.1 148826753 5225997 1806348..1806806 1 NC_009566.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1806806 recX 5225997 recX Haemophilus influenzae PittEE recombination regulator RecX YP_001291506.1 1806348 D 374930 CDS YP_001291507.1 148826754 5225998 complement(1806803..1807189) 1 NC_009566.1 COG0239 Integral membrane protein possibly involved in chromosome condensation; camphor resistance protein CrcB 1807189 5225998 CGSHiEE_09165 Haemophilus influenzae PittEE camphor resistance protein CrcB YP_001291507.1 1806803 R 374930 CDS YP_001291508.1 148826755 5225999 1809426..1810358 1 NC_009566.1 reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 1810358 5225999 CGSHiEE_09190 Haemophilus influenzae PittEE carbamate kinase YP_001291508.1 1809426 D 374930 CDS YP_001291509.1 148826756 5226000 1810463..1811992 1 NC_009566.1 COG1288 Predicted membrane protein; hypothetical protein 1811992 5226000 CGSHiEE_09195 Haemophilus influenzae PittEE hypothetical protein YP_001291509.1 1810463 D 374930 CDS