-- dump date   	20140619_104155
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
281310000001	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
281310000002	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
281310000003	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
281310000004	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
281310000005	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
281310000006	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
281310000007	acyl-activating enzyme (AAE) consensus motif; other site
281310000008	putative AMP binding site [chemical binding]; other site
281310000009	putative active site [active]
281310000010	putative CoA binding site [chemical binding]; other site
281310000011	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
281310000012	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
281310000013	active site
281310000014	motif I; other site
281310000015	motif II; other site
281310000016	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
281310000017	metal-binding heat shock protein; Provisional; Region: PRK00016
281310000018	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
281310000019	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
281310000020	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
281310000021	molybdopterin cofactor binding site; other site
281310000022	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
281310000023	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
281310000024	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
281310000025	molybdopterin cofactor binding site; other site
281310000026	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
281310000027	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
281310000028	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
281310000029	Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864
281310000030	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
281310000031	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
281310000032	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
281310000033	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
281310000034	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
281310000035	Coenzyme A binding pocket [chemical binding]; other site
281310000036	DNA polymerase III, psi subunit; Region: DNA_III_psi; TIGR00664
281310000037	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
281310000038	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
281310000039	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
281310000040	S-adenosylmethionine binding site [chemical binding]; other site
281310000041	GTPase Era; Reviewed; Region: era; PRK00089
281310000042	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
281310000043	G1 box; other site
281310000044	GTP/Mg2+ binding site [chemical binding]; other site
281310000045	Switch I region; other site
281310000046	G2 box; other site
281310000047	Switch II region; other site
281310000048	G3 box; other site
281310000049	G4 box; other site
281310000050	G5 box; other site
281310000051	KH domain; Region: KH_2; pfam07650
281310000052	ribonuclease III; Reviewed; Region: rnc; PRK00102
281310000053	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
281310000054	dimerization interface [polypeptide binding]; other site
281310000055	active site
281310000056	metal binding site [ion binding]; metal-binding site
281310000057	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
281310000058	dsRNA binding site [nucleotide binding]; other site
281310000059	signal peptidase I; Provisional; Region: PRK10861
281310000060	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
281310000061	Catalytic site [active]
281310000062	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
281310000063	GTP-binding protein LepA; Provisional; Region: PRK05433
281310000064	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
281310000065	G1 box; other site
281310000066	putative GEF interaction site [polypeptide binding]; other site
281310000067	GTP/Mg2+ binding site [chemical binding]; other site
281310000068	Switch I region; other site
281310000069	G2 box; other site
281310000070	G3 box; other site
281310000071	Switch II region; other site
281310000072	G4 box; other site
281310000073	G5 box; other site
281310000074	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
281310000075	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
281310000076	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
281310000077	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
281310000078	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
281310000079	ligand binding site [chemical binding]; other site
281310000080	active site
281310000081	UGI interface [polypeptide binding]; other site
281310000082	catalytic site [active]
281310000083	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
281310000084	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
281310000085	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
281310000086	FeS/SAM binding site; other site
281310000087	TRAM domain; Region: TRAM; pfam01938
281310000088	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
281310000089	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
281310000090	transmembrane helices; other site
281310000091	holo-ACP synthase CitX; Region: citrate_citX; TIGR03124
281310000092	triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125
281310000093	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
281310000094	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
281310000095	citrate lyase subunit gamma; Provisional; Region: PRK13253
281310000096	[citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124
281310000097	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
281310000098	putative active site [active]
281310000099	(T/H)XGH motif; other site
281310000100	lipoyl synthase; Provisional; Region: PRK05481
281310000101	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
281310000102	FeS/SAM binding site; other site
281310000103	lipoate-protein ligase B; Provisional; Region: PRK14342
281310000104	hypothetical protein; Provisional; Region: PRK04998
281310000105	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
281310000106	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
281310000107	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
281310000108	rare lipoprotein A; Region: rlpA; TIGR00413
281310000109	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
281310000110	Sporulation related domain; Region: SPOR; pfam05036
281310000111	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
281310000112	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
281310000113	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
281310000114	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
281310000115	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
281310000116	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
281310000117	putative transporter; Validated; Region: PRK03818
281310000118	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
281310000119	TrkA-C domain; Region: TrkA_C; pfam02080
281310000120	TrkA-C domain; Region: TrkA_C; pfam02080
281310000121	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
281310000122	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
281310000123	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
281310000124	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
281310000125	rod shape-determining protein MreB; Provisional; Region: PRK13927
281310000126	MreB and similar proteins; Region: MreB_like; cd10225
281310000127	nucleotide binding site [chemical binding]; other site
281310000128	Mg binding site [ion binding]; other site
281310000129	putative protofilament interaction site [polypeptide binding]; other site
281310000130	RodZ interaction site [polypeptide binding]; other site
281310000131	rod shape-determining protein MreC; Region: mreC; TIGR00219
281310000132	rod shape-determining protein MreC; Region: MreC; pfam04085
281310000133	rod shape-determining protein MreD; Region: MreD; cl01087
281310000134	TIGR01619 family protein; Region: hyp_HI0040
281310000135	Family of unknown function (DUF695); Region: DUF695; pfam05117
281310000136	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
281310000137	putative catalytic site [active]
281310000138	putative phosphate binding site [ion binding]; other site
281310000139	active site
281310000140	metal binding site A [ion binding]; metal-binding site
281310000141	DNA binding site [nucleotide binding]
281310000142	putative AP binding site [nucleotide binding]; other site
281310000143	putative metal binding site B [ion binding]; other site
281310000144	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
281310000145	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
281310000146	active site
281310000147	Predicted membrane protein [Function unknown]; Region: COG3768
281310000148	TIGR01620 family protein; Region: hyp_HI0043
281310000149	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
281310000150	YccA-like proteins; Region: YccA_like; cd10433
281310000151	Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398
281310000152	alkylphosphonate utilization operon protein PhnA; Region: phnA; TIGR00686
281310000153	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
281310000154	PhnA protein; Region: PhnA; pfam03831
281310000155	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
281310000156	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
281310000157	active site
281310000158	intersubunit interface [polypeptide binding]; other site
281310000159	catalytic residue [active]
281310000160	Glucuronate isomerase; Region: UxaC; pfam02614
281310000161	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
281310000162	D-mannonate oxidoreductase; Provisional; Region: PRK08277
281310000163	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
281310000164	putative NAD(P) binding site [chemical binding]; other site
281310000165	active site
281310000166	NTHIp0058B; similar to: 2-dehydro-3-deoxygluconokinase, C-terminal fragment
281310000167	NTHIp0058A; similar to: 2-dehydro-3-deoxygluconokinase, N-terminal fragment
281310000168	DctM-like transporters; Region: DctM; pfam06808
281310000169	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
281310000170	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
281310000171	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
281310000172	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
281310000173	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
281310000174	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
281310000175	putative NAD(P) binding site [chemical binding]; other site
281310000176	catalytic Zn binding site [ion binding]; other site
281310000177	structural Zn binding site [ion binding]; other site
281310000178	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
281310000179	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
281310000180	DNA-binding site [nucleotide binding]; DNA binding site
281310000181	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
281310000182	mannonate dehydratase; Provisional; Region: PRK03906
281310000183	mannonate dehydratase; Region: uxuA; TIGR00695
281310000184	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
281310000185	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
281310000186	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
281310000187	GIY-YIG motif/motif A; other site
281310000188	active site
281310000189	catalytic site [active]
281310000190	putative DNA binding site [nucleotide binding]; other site
281310000191	metal binding site [ion binding]; metal-binding site
281310000192	UvrB/uvrC motif; Region: UVR; pfam02151
281310000193	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
281310000194	Helix-hairpin-helix motif; Region: HHH; pfam00633
281310000195	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
281310000196	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
281310000197	Ligand binding site; other site
281310000198	oligomer interface; other site
281310000199	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
281310000200	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
281310000201	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
281310000202	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
281310000203	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
281310000204	Walker A/P-loop; other site
281310000205	ATP binding site [chemical binding]; other site
281310000206	Q-loop/lid; other site
281310000207	ABC transporter signature motif; other site
281310000208	Walker B; other site
281310000209	D-loop; other site
281310000210	H-loop/switch region; other site
281310000211	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
281310000212	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
281310000213	ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360
281310000214	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
281310000215	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
281310000216	poly(A) polymerase; Region: pcnB; TIGR01942
281310000217	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
281310000218	active site
281310000219	NTP binding site [chemical binding]; other site
281310000220	metal binding triad [ion binding]; metal-binding site
281310000221	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
281310000222	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
281310000223	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
281310000224	catalytic center binding site [active]
281310000225	ATP binding site [chemical binding]; other site
281310000226	tRNA threonylcarbamoyl adenosine modification protein YjeE; Region: T6A_YjeE; TIGR00150
281310000227	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
281310000228	active site
281310000229	metal binding site [ion binding]; metal-binding site
281310000230	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
281310000231	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
281310000232	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
281310000233	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
281310000234	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
281310000235	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
281310000236	ATP binding site [chemical binding]; other site
281310000237	Mg2+ binding site [ion binding]; other site
281310000238	G-X-G motif; other site
281310000239	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
281310000240	ATP binding site [chemical binding]; other site
281310000241	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
281310000242	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
281310000243	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
281310000244	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
281310000245	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
281310000246	metal binding triad; other site
281310000247	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
281310000248	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
281310000249	metal binding triad; other site
281310000250	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
281310000251	DNA repair protein RecN; Region: recN; TIGR00634
281310000252	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
281310000253	Walker A/P-loop; other site
281310000254	ATP binding site [chemical binding]; other site
281310000255	Q-loop/lid; other site
281310000256	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
281310000257	ABC transporter signature motif; other site
281310000258	Walker B; other site
281310000259	D-loop; other site
281310000260	H-loop/switch region; other site
281310000261	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
281310000262	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
281310000263	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
281310000264	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
281310000265	dimer interface [polypeptide binding]; other site
281310000266	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
281310000267	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
281310000268	active site
281310000269	NTP binding site [chemical binding]; other site
281310000270	metal binding triad [ion binding]; metal-binding site
281310000271	antibiotic binding site [chemical binding]; other site
281310000272	nucleotidyltransferase substrate binding protein, HI0074 family; Region: HI0074; TIGR01987
281310000273	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
281310000274	ATP cone domain; Region: ATP-cone; pfam03477
281310000275	Class III ribonucleotide reductase; Region: RNR_III; cd01675
281310000276	effector binding site; other site
281310000277	active site
281310000278	Zn binding site [ion binding]; other site
281310000279	glycine loop; other site
281310000280	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
281310000281	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
281310000282	active site
281310000283	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
281310000284	catalytic triad [active]
281310000285	dimer interface [polypeptide binding]; other site
281310000286	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
281310000287	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
281310000288	active site
281310000289	HIGH motif; other site
281310000290	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
281310000291	KMSKS motif; other site
281310000292	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
281310000293	tRNA binding surface [nucleotide binding]; other site
281310000294	anticodon binding site; other site
281310000295	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
281310000296	substrate binding site [chemical binding]; other site
281310000297	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3692
281310000298	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
281310000299	active site
281310000300	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
281310000301	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
281310000302	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
281310000303	catalytic residues [active]
281310000304	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
281310000305	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
281310000306	putative ligand binding site [chemical binding]; other site
281310000307	putative NAD binding site [chemical binding]; other site
281310000308	catalytic site [active]
281310000309	cystathionine gamma-synthase; Reviewed; Region: PRK08247
281310000310	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
281310000311	homodimer interface [polypeptide binding]; other site
281310000312	substrate-cofactor binding pocket; other site
281310000313	pyridoxal 5'-phosphate binding site [chemical binding]; other site
281310000314	catalytic residue [active]
281310000315	ICEhin1056-like insertion; NTHIpnote0000
281310000316	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
281310000317	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
281310000318	P-loop; other site
281310000319	Magnesium ion binding site [ion binding]; other site
281310000320	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
281310000321	Magnesium ion binding site [ion binding]; other site
281310000322	replicative DNA helicase; Region: DnaB; TIGR00665
281310000323	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
281310000324	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
281310000325	Walker A motif; other site
281310000326	ATP binding site [chemical binding]; other site
281310000327	Walker B motif; other site
281310000328	DNA binding loops [nucleotide binding]
281310000329	integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764
281310000330	ParB-like nuclease domain; Region: ParBc; pfam02195
281310000331	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
281310000332	integrating conjugative element protein, PFL_4669 family; Region: ICE_PFL4669; TIGR03761
281310000333	Protein of unknown function (DUF3158); Region: DUF3158; pfam11358
281310000334	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
281310000335	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
281310000336	dimer interface [polypeptide binding]; other site
281310000337	ssDNA binding site [nucleotide binding]; other site
281310000338	tetramer (dimer of dimers) interface [polypeptide binding]; other site
281310000339	YedD-like protein; Region: YedD; cl08117
281310000340	DNA topoisomerase III; Provisional; Region: PRK07726
281310000341	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
281310000342	active site
281310000343	putative interdomain interaction site [polypeptide binding]; other site
281310000344	putative metal-binding site [ion binding]; other site
281310000345	putative nucleotide binding site [chemical binding]; other site
281310000346	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
281310000347	domain I; other site
281310000348	DNA binding groove [nucleotide binding]
281310000349	phosphate binding site [ion binding]; other site
281310000350	domain II; other site
281310000351	domain III; other site
281310000352	nucleotide binding site [chemical binding]; other site
281310000353	catalytic site [active]
281310000354	domain IV; other site
281310000355	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
281310000356	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
281310000357	Domain of unknown function (DUF3560); Region: DUF3560; pfam12083
281310000358	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
281310000359	MPN+ (JAMM) motif; other site
281310000360	Zinc-binding site [ion binding]; other site
281310000361	conjugal transfer protein TrbP; Provisional; Region: PRK13882
281310000362	TraX protein; Region: TraX; pfam05857
281310000363	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
281310000364	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
281310000365	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
281310000366	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
281310000367	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
281310000368	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
281310000369	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
281310000370	integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747
281310000371	integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690
281310000372	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
281310000373	Protein of unknown function (DUF2976); Region: DUF2976; pfam11190
281310000374	Protein of unknown function (DUF3487); Region: DUF3487; pfam11990
281310000375	integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746
281310000376	Protein of unknown function (DUF3438); Region: DUF3438; pfam11920
281310000377	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
281310000378	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
281310000379	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
281310000380	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
281310000381	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
281310000382	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
281310000383	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
281310000384	multiple promoter invertase; Provisional; Region: mpi; PRK13413
281310000385	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
281310000386	catalytic residues [active]
281310000387	catalytic nucleophile [active]
281310000388	Presynaptic Site I dimer interface [polypeptide binding]; other site
281310000389	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
281310000390	Synaptic Flat tetramer interface [polypeptide binding]; other site
281310000391	Synaptic Site I dimer interface [polypeptide binding]; other site
281310000392	DNA binding site [nucleotide binding]
281310000393	Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796
281310000394	beta-lactamase TEM; Provisional; Region: PRK15442
281310000395	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
281310000396	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
281310000397	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
281310000398	catalytic residue [active]
281310000399	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
281310000400	integrating conjugative element protein, PFL_4709 family; Region: conj_TIGR03757
281310000401	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
281310000402	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
281310000403	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
281310000404	multiple promoter invertase; Provisional; Region: mpi; PRK13413
281310000405	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
281310000406	catalytic residues [active]
281310000407	catalytic nucleophile [active]
281310000408	Presynaptic Site I dimer interface [polypeptide binding]; other site
281310000409	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
281310000410	Synaptic Flat tetramer interface [polypeptide binding]; other site
281310000411	Synaptic Site I dimer interface [polypeptide binding]; other site
281310000412	DNA binding site [nucleotide binding]
281310000413	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
281310000414	DNA-binding interface [nucleotide binding]; DNA binding site
281310000415	Abi-like protein; Region: Abi_2; cl01988
281310000416	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
281310000417	Putative helicase; Region: TraI_2; pfam07514
281310000418	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
281310000419	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
281310000420	active site
281310000421	catalytic residues [active]
281310000422	DNA binding site [nucleotide binding]
281310000423	Int/Topo IB signature motif; other site
281310000424	Degenerate tRNA remnant resulting from ICEhin1056-like insertion; NTHIpnote0001
281310000425	threonine synthase; Validated; Region: PRK09225
281310000426	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
281310000427	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
281310000428	catalytic residue [active]
281310000429	homoserine kinase; Region: thrB; TIGR00191
281310000430	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
281310000431	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
281310000432	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
281310000433	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
281310000434	nucleotide binding site [chemical binding]; other site
281310000435	substrate binding site [chemical binding]; other site
281310000436	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
281310000437	dimer interface [polypeptide binding]; other site
281310000438	putative threonine allosteric regulatory site; other site
281310000439	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
281310000440	putative threonine allosteric regulatory site; other site
281310000441	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
281310000442	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
281310000443	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
281310000444	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
281310000445	catalytic residue [active]
281310000446	Glycerate kinase family; Region: Gly_kinase; pfam02595
281310000447	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
281310000448	fructuronate transporter; Provisional; Region: PRK10034; cl15264
281310000449	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
281310000450	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
281310000451	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
281310000452	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
281310000453	NTHIp0174A; similar to: glycerol-3-phosphate regulon repressor, N-terminal fragment
281310000454	Methyltransferase domain; Region: Methyltransf_31; pfam13847
281310000455	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
281310000456	S-adenosylmethionine binding site [chemical binding]; other site
281310000457	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
281310000458	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
281310000459	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
281310000460	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310000461	dimer interface [polypeptide binding]; other site
281310000462	conserved gate region; other site
281310000463	putative PBP binding loops; other site
281310000464	ABC-ATPase subunit interface; other site
281310000465	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310000466	dimer interface [polypeptide binding]; other site
281310000467	conserved gate region; other site
281310000468	putative PBP binding loops; other site
281310000469	ABC-ATPase subunit interface; other site
281310000470	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
281310000471	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
281310000472	Walker A/P-loop; other site
281310000473	ATP binding site [chemical binding]; other site
281310000474	Q-loop/lid; other site
281310000475	ABC transporter signature motif; other site
281310000476	Walker B; other site
281310000477	D-loop; other site
281310000478	H-loop/switch region; other site
281310000479	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
281310000480	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
281310000481	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
281310000482	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
281310000483	metal binding site [ion binding]; metal-binding site
281310000484	dimer interface [polypeptide binding]; other site
281310000485	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
281310000486	ArsC family; Region: ArsC; pfam03960
281310000487	putative catalytic residues [active]
281310000488	heat shock protein 90; Provisional; Region: PRK05218
281310000489	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
281310000490	ATP binding site [chemical binding]; other site
281310000491	Mg2+ binding site [ion binding]; other site
281310000492	G-X-G motif; other site
281310000493	Uncharacterized conserved protein [Function unknown]; Region: COG0327
281310000494	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
281310000495	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
281310000496	HsdM N-terminal domain; Region: HsdM_N; pfam12161
281310000497	Methyltransferase domain; Region: Methyltransf_26; pfam13659
281310000498	Divergent AAA domain; Region: AAA_4; pfam04326
281310000499	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
281310000500	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
281310000501	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
281310000502	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
281310000503	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
281310000504	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
281310000505	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
281310000506	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
281310000507	signal recognition particle protein; Provisional; Region: PRK10867
281310000508	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
281310000509	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
281310000510	P loop; other site
281310000511	GTP binding site [chemical binding]; other site
281310000512	Signal peptide binding domain; Region: SRP_SPB; pfam02978
281310000513	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
281310000514	Domain of unknown function DUF21; Region: DUF21; pfam01595
281310000515	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
281310000516	Transporter associated domain; Region: CorC_HlyC; smart01091
281310000517	Uncharacterized conserved protein [Function unknown]; Region: COG2966
281310000518	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
281310000519	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
281310000520	Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765
281310000521	seryl-tRNA synthetase; Provisional; Region: PRK05431
281310000522	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
281310000523	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
281310000524	dimer interface [polypeptide binding]; other site
281310000525	active site
281310000526	motif 1; other site
281310000527	motif 2; other site
281310000528	motif 3; other site
281310000529	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
281310000530	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
281310000531	C-terminal domain interface [polypeptide binding]; other site
281310000532	GSH binding site (G-site) [chemical binding]; other site
281310000533	dimer interface [polypeptide binding]; other site
281310000534	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
281310000535	dimer interface [polypeptide binding]; other site
281310000536	N-terminal domain interface [polypeptide binding]; other site
281310000537	substrate binding pocket (H-site) [chemical binding]; other site
281310000538	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
281310000539	Helix-turn-helix domain; Region: HTH_28; pfam13518
281310000540	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
281310000541	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
281310000542	N-terminal plug; other site
281310000543	ligand-binding site [chemical binding]; other site
281310000544	rRNA operon region 1; NTHIpnote0002
281310000545	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
281310000546	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
281310000547	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
281310000548	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
281310000549	putative RNA binding site [nucleotide binding]; other site
281310000550	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
281310000551	S-adenosylmethionine binding site [chemical binding]; other site
281310000552	murein transglycosylase A; Provisional; Region: mltA; PRK11162
281310000553	MltA specific insert domain; Region: MltA; smart00925
281310000554	3D domain; Region: 3D; pfam06725
281310000555	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
281310000556	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
281310000557	putative ATP binding site [chemical binding]; other site
281310000558	putative substrate interface [chemical binding]; other site
281310000559	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
281310000560	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
281310000561	metal binding site [ion binding]; metal-binding site
281310000562	Uncharacterized integral membrane protein [Function unknown]; Region: COG5413
281310000563	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
281310000564	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
281310000565	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
281310000566	cystathionine beta-lyase; Provisional; Region: PRK08114
281310000567	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
281310000568	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
281310000569	catalytic residue [active]
281310000570	peroxidase; Provisional; Region: PRK15000
281310000571	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
281310000572	dimer interface [polypeptide binding]; other site
281310000573	decamer (pentamer of dimers) interface [polypeptide binding]; other site
281310000574	catalytic triad [active]
281310000575	peroxidatic and resolving cysteines [active]
281310000576	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
281310000577	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
281310000578	dimer interface [polypeptide binding]; other site
281310000579	substrate binding site [chemical binding]; other site
281310000580	metal binding sites [ion binding]; metal-binding site
281310000581	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
281310000582	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
281310000583	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
281310000584	Sugar specificity; other site
281310000585	Pyrimidine base specificity; other site
281310000586	ATP-binding site [chemical binding]; other site
281310000587	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
281310000588	trimer interface [polypeptide binding]; other site
281310000589	active site
281310000590	TIGR03545 family protein; Region: TIGR03545
281310000591	putative arabinose transporter; Provisional; Region: PRK03545
281310000592	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
281310000593	putative substrate translocation pore; other site
281310000594	GTP-binding protein Der; Reviewed; Region: PRK00093
281310000595	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
281310000596	G1 box; other site
281310000597	GTP/Mg2+ binding site [chemical binding]; other site
281310000598	Switch I region; other site
281310000599	G2 box; other site
281310000600	Switch II region; other site
281310000601	G3 box; other site
281310000602	G4 box; other site
281310000603	G5 box; other site
281310000604	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
281310000605	G1 box; other site
281310000606	GTP/Mg2+ binding site [chemical binding]; other site
281310000607	Switch I region; other site
281310000608	G2 box; other site
281310000609	G3 box; other site
281310000610	Switch II region; other site
281310000611	G4 box; other site
281310000612	G5 box; other site
281310000613	exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573
281310000614	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
281310000615	active site
281310000616	catalytic site [active]
281310000617	substrate binding site [chemical binding]; other site
281310000618	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
281310000619	RNA/DNA hybrid binding site [nucleotide binding]; other site
281310000620	active site
281310000621	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
281310000622	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
281310000623	trimer interface [polypeptide binding]; other site
281310000624	eyelet of channel; other site
281310000625	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
281310000626	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
281310000627	active site
281310000628	dimer interface [polypeptide binding]; other site
281310000629	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
281310000630	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
281310000631	active site
281310000632	trimer interface [polypeptide binding]; other site
281310000633	allosteric site; other site
281310000634	active site lid [active]
281310000635	hexamer (dimer of trimers) interface [polypeptide binding]; other site
281310000636	N-acetylneuraminate lyase; Provisional; Region: PRK04147
281310000637	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
281310000638	inhibitor site; inhibition site
281310000639	active site
281310000640	dimer interface [polypeptide binding]; other site
281310000641	catalytic residue [active]
281310000642	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
281310000643	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
281310000644	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
281310000645	putative active site [active]
281310000646	N-acetylmannosamine kinase; Provisional; Region: PRK05082
281310000647	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
281310000648	nucleotide binding site [chemical binding]; other site
281310000649	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
281310000650	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
281310000651	putative active site cavity [active]
281310000652	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
281310000653	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
281310000654	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
281310000655	DctM-like transporters; Region: DctM; pfam06808
281310000656	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
281310000657	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
281310000658	Kelch motif; Region: Kelch_1; pfam01344
281310000659	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
281310000660	FtsH protease regulator HflC; Provisional; Region: PRK11029
281310000661	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
281310000662	FtsH protease regulator HflK; Provisional; Region: PRK10930
281310000663	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
281310000664	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
281310000665	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
281310000666	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
281310000667	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
281310000668	acyl carrier protein; Provisional; Region: acpP; PRK00982
281310000669	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
281310000670	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
281310000671	NAD(P) binding site [chemical binding]; other site
281310000672	homotetramer interface [polypeptide binding]; other site
281310000673	homodimer interface [polypeptide binding]; other site
281310000674	active site
281310000675	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
281310000676	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
281310000677	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
281310000678	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
281310000679	dimer interface [polypeptide binding]; other site
281310000680	active site
281310000681	CoA binding pocket [chemical binding]; other site
281310000682	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
281310000683	hypothetical protein; Provisional; Region: PRK11193
281310000684	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
281310000685	glutathione reductase; Validated; Region: PRK06116
281310000686	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
281310000687	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
281310000688	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
281310000689	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG3056
281310000690	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
281310000691	NTHIp0253A; similar to: BolA homolog, N-terminal fragment
281310000692	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
281310000693	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
281310000694	E3 interaction surface; other site
281310000695	lipoyl attachment site [posttranslational modification]; other site
281310000696	Pleckstrin homology-like domain; Region: PH-like; cl17171
281310000697	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
281310000698	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
281310000699	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869
281310000700	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
281310000701	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
281310000702	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
281310000703	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
281310000704	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
281310000705	FAD binding pocket [chemical binding]; other site
281310000706	FAD binding motif [chemical binding]; other site
281310000707	phosphate binding motif [ion binding]; other site
281310000708	beta-alpha-beta structure motif; other site
281310000709	NAD binding pocket [chemical binding]; other site
281310000710	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
281310000711	ApbE family; Region: ApbE; pfam02424
281310000712	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991
281310000713	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
281310000714	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
281310000715	Ligand Binding Site [chemical binding]; other site
281310000716	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
281310000717	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
281310000718	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
281310000719	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
281310000720	RNA binding surface [nucleotide binding]; other site
281310000721	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
281310000722	active site
281310000723	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
281310000724	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
281310000725	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
281310000726	FeS/SAM binding site; other site
281310000727	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
281310000728	Pyruvate formate lyase 1; Region: PFL1; cd01678
281310000729	coenzyme A binding site [chemical binding]; other site
281310000730	active site
281310000731	catalytic residues [active]
281310000732	glycine loop; other site
281310000733	formate transporter FocA; Region: formate_focA; TIGR04060
281310000734	fructokinase; Reviewed; Region: PRK09557
281310000735	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
281310000736	nucleotide binding site [chemical binding]; other site
281310000737	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
281310000738	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
281310000739	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
281310000740	S-formylglutathione hydrolase; Region: PLN02442
281310000741	NTHIp0276B; similar to:  alcohol dehydrogenase class III, C-terminal fragment
281310000742	NTHIp0276A; similar to:  alcohol dehydrogenase class III, N-terminal fragment
281310000743	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
281310000744	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
281310000745	DNA binding residues [nucleotide binding]
281310000746	putative dimer interface [polypeptide binding]; other site
281310000747	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
281310000748	sec-independent translocase; Provisional; Region: PRK01770
281310000749	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
281310000750	glutamate dehydrogenase; Provisional; Region: PRK09414
281310000751	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
281310000752	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
281310000753	NAD(P) binding site [chemical binding]; other site
281310000754	ferric uptake regulator; Provisional; Region: fur; PRK09462
281310000755	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
281310000756	metal binding site 2 [ion binding]; metal-binding site
281310000757	putative DNA binding helix; other site
281310000758	metal binding site 1 [ion binding]; metal-binding site
281310000759	dimer interface [polypeptide binding]; other site
281310000760	structural Zn2+ binding site [ion binding]; other site
281310000761	flavodoxin FldA; Validated; Region: PRK09267
281310000762	acyl-CoA esterase; Provisional; Region: PRK10673
281310000763	PGAP1-like protein; Region: PGAP1; pfam07819
281310000764	replication initiation regulator SeqA; Provisional; Region: PRK11187
281310000765	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
281310000766	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
281310000767	acyl-activating enzyme (AAE) consensus motif; other site
281310000768	putative AMP binding site [chemical binding]; other site
281310000769	putative active site [active]
281310000770	putative CoA binding site [chemical binding]; other site
281310000771	hypothetical protein; Provisional; Region: PRK11281
281310000772	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
281310000773	Mechanosensitive ion channel; Region: MS_channel; pfam00924
281310000774	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
281310000775	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
281310000776	Tetramer interface [polypeptide binding]; other site
281310000777	active site
281310000778	FMN-binding site [chemical binding]; other site
281310000779	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
281310000780	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
281310000781	hypothetical protein; Provisional; Region: PRK10621
281310000782	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
281310000783	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
281310000784	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
281310000785	putative acyl-acceptor binding pocket; other site
281310000786	selenophosphate synthetase; Provisional; Region: PRK00943
281310000787	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
281310000788	dimerization interface [polypeptide binding]; other site
281310000789	putative ATP binding site [chemical binding]; other site
281310000790	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
281310000791	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
281310000792	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
281310000793	RimM N-terminal domain; Region: RimM; pfam01782
281310000794	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
281310000795	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
281310000796	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
281310000797	active site
281310000798	metal binding site [ion binding]; metal-binding site
281310000799	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
281310000800	shikimate kinase; Reviewed; Region: aroK; PRK00131
281310000801	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
281310000802	ADP binding site [chemical binding]; other site
281310000803	magnesium binding site [ion binding]; other site
281310000804	putative shikimate binding site; other site
281310000805	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
281310000806	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
281310000807	active site
281310000808	dimer interface [polypeptide binding]; other site
281310000809	metal binding site [ion binding]; metal-binding site
281310000810	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
281310000811	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
281310000812	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
281310000813	active site
281310000814	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
281310000815	dimerization interface [polypeptide binding]; other site
281310000816	active site
281310000817	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
281310000818	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
281310000819	peptide binding site [polypeptide binding]; other site
281310000820	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
281310000821	oligopeptidase A; Provisional; Region: PRK10911
281310000822	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
281310000823	active site
281310000824	Zn binding site [ion binding]; other site
281310000825	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
281310000826	HsdM N-terminal domain; Region: HsdM_N; pfam12161
281310000827	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
281310000828	S-adenosylmethionine binding site [chemical binding]; other site
281310000829	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
281310000830	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
281310000831	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
281310000832	AAA domain; Region: AAA_13; pfam13166
281310000833	AAA domain; Region: AAA_13; pfam13166
281310000834	Virulence protein [General function prediction only]; Region: COG3943
281310000835	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
281310000836	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
281310000837	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
281310000838	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
281310000839	ATP binding site [chemical binding]; other site
281310000840	putative Mg++ binding site [ion binding]; other site
281310000841	Predicted membrane protein [Function unknown]; Region: COG3059
281310000842	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
281310000843	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
281310000844	dimer interface [polypeptide binding]; other site
281310000845	phosphorylation site [posttranslational modification]
281310000846	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
281310000847	ATP binding site [chemical binding]; other site
281310000848	Mg2+ binding site [ion binding]; other site
281310000849	G-X-G motif; other site
281310000850	Response regulator receiver domain; Region: Response_reg; pfam00072
281310000851	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
281310000852	active site
281310000853	phosphorylation site [posttranslational modification]
281310000854	intermolecular recognition site; other site
281310000855	dimerization interface [polypeptide binding]; other site
281310000856	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
281310000857	putative binding surface; other site
281310000858	active site
281310000859	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
281310000860	putative uracil binding site [chemical binding]; other site
281310000861	putative active site [active]
281310000862	rRNA operon region 2; NTHIpnote0003
281310000863	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
281310000864	HTH domain; Region: HTH_11; cl17392
281310000865	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
281310000866	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
281310000867	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
281310000868	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
281310000869	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
281310000870	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
281310000871	active site
281310000872	GMP synthase; Reviewed; Region: guaA; PRK00074
281310000873	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
281310000874	AMP/PPi binding site [chemical binding]; other site
281310000875	candidate oxyanion hole; other site
281310000876	catalytic triad [active]
281310000877	potential glutamine specificity residues [chemical binding]; other site
281310000878	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
281310000879	ATP Binding subdomain [chemical binding]; other site
281310000880	Ligand Binding sites [chemical binding]; other site
281310000881	Dimerization subdomain; other site
281310000882	Predicted permeases [General function prediction only]; Region: RarD; COG2962
281310000883	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
281310000884	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
281310000885	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
281310000886	putative DNA binding site [nucleotide binding]; other site
281310000887	putative Zn2+ binding site [ion binding]; other site
281310000888	AsnC family; Region: AsnC_trans_reg; pfam01037
281310000889	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
281310000890	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
281310000891	uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022
281310000892	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
281310000893	active site
281310000894	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
281310000895	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
281310000896	RNase E interface [polypeptide binding]; other site
281310000897	trimer interface [polypeptide binding]; other site
281310000898	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
281310000899	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
281310000900	RNase E interface [polypeptide binding]; other site
281310000901	trimer interface [polypeptide binding]; other site
281310000902	active site
281310000903	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
281310000904	putative nucleic acid binding region [nucleotide binding]; other site
281310000905	G-X-X-G motif; other site
281310000906	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
281310000907	RNA binding site [nucleotide binding]; other site
281310000908	domain interface; other site
281310000909	Lipoprotein NlpI, contains TPR repeats [General function prediction only]; Region: NlpI; COG4785
281310000910	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
281310000911	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
281310000912	ATP binding site [chemical binding]; other site
281310000913	Mg++ binding site [ion binding]; other site
281310000914	motif III; other site
281310000915	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
281310000916	nucleotide binding region [chemical binding]; other site
281310000917	ATP-binding site [chemical binding]; other site
281310000918	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
281310000919	putative RNA binding site [nucleotide binding]; other site
281310000920	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
281310000921	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
281310000922	substrate binding pocket [chemical binding]; other site
281310000923	membrane-bound complex binding site; other site
281310000924	hinge residues; other site
281310000925	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
281310000926	N-acetyl-D-glucosamine binding site [chemical binding]; other site
281310000927	catalytic residue [active]
281310000928	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036
281310000929	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
281310000930	ArsC family; Region: ArsC; pfam03960
281310000931	catalytic residues [active]
281310000932	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
281310000933	Domain of unknown function DUF20; Region: UPF0118; pfam01594
281310000934	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
281310000935	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
281310000936	Protein export membrane protein; Region: SecD_SecF; pfam02355
281310000937	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
281310000938	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
281310000939	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
281310000940	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
281310000941	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
281310000942	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
281310000943	CPxP  motif; other site
281310000944	Hemerythrin-like domain; Region: Hr-like; cd12108
281310000945	Fe binding site [ion binding]; other site
281310000946	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
281310000947	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
281310000948	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
281310000949	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
281310000950	Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395
281310000951	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
281310000952	Autotransporter beta-domain; Region: Autotransporter; pfam03797
281310000953	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
281310000954	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
281310000955	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
281310000956	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
281310000957	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
281310000958	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
281310000959	dimer interface [polypeptide binding]; other site
281310000960	ssDNA binding site [nucleotide binding]; other site
281310000961	tetramer (dimer of dimers) interface [polypeptide binding]; other site
281310000962	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
281310000963	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
281310000964	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
281310000965	TonB system transport protein ExbD, group 2; Region: ExbD_2; TIGR02804
281310000966	tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805
281310000967	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
281310000968	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
281310000969	catalytic triad [active]
281310000970	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
281310000971	dihydrodipicolinate synthase; Region: dapA; TIGR00674
281310000972	dimer interface [polypeptide binding]; other site
281310000973	active site
281310000974	catalytic residue [active]
281310000975	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
281310000976	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
281310000977	30S subunit binding site; other site
281310000978	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
281310000979	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
281310000980	Ligand binding site; other site
281310000981	metal-binding site
281310000982	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
281310000983	active site
281310000984	dimerization interface [polypeptide binding]; other site
281310000985	3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723
281310000986	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293
281310000987	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
281310000988	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
281310000989	putative active site [active]
281310000990	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
281310000991	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
281310000992	N-terminal plug; other site
281310000993	ligand-binding site [chemical binding]; other site
281310000994	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
281310000995	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
281310000996	Surface antigen; Region: Bac_surface_Ag; pfam01103
281310000997	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
281310000998	haemagglutination activity domain; Region: Haemagg_act; pfam05860
281310000999	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
281310001000	homooctamer interface [polypeptide binding]; other site
281310001001	active site
281310001002	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
281310001003	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
281310001004	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
281310001005	HAMP domain; Region: HAMP; pfam00672
281310001006	Histidine kinase; Region: HisKA_3; pfam07730
281310001007	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
281310001008	ATP binding site [chemical binding]; other site
281310001009	Mg2+ binding site [ion binding]; other site
281310001010	G-X-G motif; other site
281310001011	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
281310001012	FAD binding domain; Region: FAD_binding_4; pfam01565
281310001013	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
281310001014	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
281310001015	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
281310001016	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
281310001017	DNA binding residues [nucleotide binding]
281310001018	NTHIp0377B; similar to: tRNA-dihydrouridine synthase C, C-terminal fragment
281310001019	NTHIp0377A; similar to: tRNA-dihydrouridine synthase C, N-terminal fragment
281310001020	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
281310001021	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
281310001022	putative metal binding site [ion binding]; other site
281310001023	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
281310001024	HSP70 interaction site [polypeptide binding]; other site
281310001025	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
281310001026	active site
281310001027	ribonuclease PH; Reviewed; Region: rph; PRK00173
281310001028	Ribonuclease PH; Region: RNase_PH_bact; cd11362
281310001029	hexamer interface [polypeptide binding]; other site
281310001030	active site
281310001031	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
281310001032	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
281310001033	HIGH motif; other site
281310001034	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
281310001035	active site
281310001036	KMSKS motif; other site
281310001037	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
281310001038	Sulfatase; Region: Sulfatase; cl17466
281310001039	hypothetical protein; Reviewed; Region: PRK01637
281310001040	hypothetical protein; Provisional; Region: PRK01752
281310001041	SEC-C motif; Region: SEC-C; pfam02810
281310001042	SEC-C motif; Region: SEC-C; pfam02810
281310001043	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
281310001044	MOSC domain; Region: MOSC; pfam03473
281310001045	3-alpha domain; Region: 3-alpha; pfam03475
281310001046	uridine phosphorylase; Provisional; Region: PRK11178
281310001047	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
281310001048	metabolite-proton symporter; Region: 2A0106; TIGR00883
281310001049	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
281310001050	putative substrate translocation pore; other site
281310001051	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
281310001052	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
281310001053	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
281310001054	dimer interface [polypeptide binding]; other site
281310001055	tetramer interface [polypeptide binding]; other site
281310001056	PYR/PP interface [polypeptide binding]; other site
281310001057	TPP binding site [chemical binding]; other site
281310001058	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
281310001059	TPP-binding site; other site
281310001060	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
281310001061	isochorismate synthases; Region: isochor_syn; TIGR00543
281310001062	aminotransferase AlaT; Validated; Region: PRK09265
281310001063	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
281310001064	pyridoxal 5'-phosphate binding site [chemical binding]; other site
281310001065	homodimer interface [polypeptide binding]; other site
281310001066	catalytic residue [active]
281310001067	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222
281310001068	aromatic amino acid transport protein; Region: araaP; TIGR00837
281310001069	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
281310001070	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
281310001071	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
281310001072	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
281310001073	serine transporter; Region: stp; TIGR00814
281310001074	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
281310001075	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
281310001076	metal-binding site [ion binding]
281310001077	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
281310001078	Soluble P-type ATPase [General function prediction only]; Region: COG4087
281310001079	NTHIp0400C; similar to: probable inorganic ion transport protein, C-terminal fragment
281310001080	NTHIp0400B; similar to: probable inorganic ion transport protein, central fragment
281310001081	NTHIp0400A; similar to: probable inorganic ion transport protein, N-terminal fragment
281310001082	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
281310001083	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
281310001084	DNA binding residues [nucleotide binding]
281310001085	dimer interface [polypeptide binding]; other site
281310001086	copper binding site [ion binding]; other site
281310001087	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
281310001088	dimerization interface [polypeptide binding]; other site
281310001089	DNA binding site [nucleotide binding]
281310001090	corepressor binding sites; other site
281310001091	transcription termination factor Rho; Provisional; Region: rho; PRK09376
281310001092	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
281310001093	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
281310001094	RNA binding site [nucleotide binding]; other site
281310001095	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
281310001096	multimer interface [polypeptide binding]; other site
281310001097	Walker A motif; other site
281310001098	ATP binding site [chemical binding]; other site
281310001099	Walker B motif; other site
281310001100	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
281310001101	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
281310001102	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
281310001103	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
281310001104	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
281310001105	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
281310001106	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
281310001107	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
281310001108	Walker A motif; other site
281310001109	ATP binding site [chemical binding]; other site
281310001110	Walker B motif; other site
281310001111	putative major pilin subunit; Provisional; Region: PRK10574
281310001112	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
281310001113	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
281310001114	amidase catalytic site [active]
281310001115	Zn binding residues [ion binding]; other site
281310001116	substrate binding site [chemical binding]; other site
281310001117	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
281310001118	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
281310001119	Transporter associated domain; Region: CorC_HlyC; smart01091
281310001120	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
281310001121	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
281310001122	putative active site [active]
281310001123	catalytic triad [active]
281310001124	putative dimer interface [polypeptide binding]; other site
281310001125	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
281310001126	RNA methyltransferase, RsmE family; Region: TIGR00046
281310001127	Putative transcriptional regulator [Transcription]; Region: COG1678
281310001128	RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250
281310001129	NTHIp0417B; similar to: recombination associated protein RdgC, C-terminal fragment
281310001130	NTHIp0417A; similar to: recombination associated protein RdgC, N-terminal fragment
281310001131	integrase; Provisional; Region: PRK09692
281310001132	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
281310001133	active site
281310001134	Int/Topo IB signature motif; other site
281310001135	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
281310001136	non-specific DNA binding site [nucleotide binding]; other site
281310001137	salt bridge; other site
281310001138	sequence-specific DNA binding site [nucleotide binding]; other site
281310001139	GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440
281310001140	GIY-YIG motif/motif A; other site
281310001141	putative active site [active]
281310001142	putative metal binding site [ion binding]; other site
281310001143	Helix-turn-helix domain; Region: HTH_17; cl17695
281310001144	Replicase family; Region: Replicase; pfam03090
281310001145	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
281310001146	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
281310001147	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
281310001148	phenyl proprionate permease family protein; Region: 2A0127; TIGR00902
281310001149	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
281310001150	putative substrate translocation pore; other site
281310001151	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
281310001152	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
281310001153	active site
281310001154	Int/Topo IB signature motif; other site
281310001155	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
281310001156	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
281310001157	Walker A motif; other site
281310001158	ATP binding site [chemical binding]; other site
281310001159	Walker B motif; other site
281310001160	arginine finger; other site
281310001161	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
281310001162	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
281310001163	RuvA N terminal domain; Region: RuvA_N; pfam01330
281310001164	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
281310001165	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
281310001166	active site
281310001167	putative DNA-binding cleft [nucleotide binding]; other site
281310001168	dimer interface [polypeptide binding]; other site
281310001169	hypothetical protein; Validated; Region: PRK00110
281310001170	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
281310001171	nudix motif; other site
281310001172	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
281310001173	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
281310001174	dimer interface [polypeptide binding]; other site
281310001175	anticodon binding site; other site
281310001176	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
281310001177	homodimer interface [polypeptide binding]; other site
281310001178	motif 1; other site
281310001179	active site
281310001180	motif 2; other site
281310001181	GAD domain; Region: GAD; pfam02938
281310001182	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
281310001183	active site
281310001184	motif 3; other site
281310001185	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
281310001186	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
281310001187	S-adenosylmethionine binding site [chemical binding]; other site
281310001188	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
281310001189	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
281310001190	oligomeric interface; other site
281310001191	putative active site [active]
281310001192	homodimer interface [polypeptide binding]; other site
281310001193	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
281310001194	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
281310001195	dimer interface [polypeptide binding]; other site
281310001196	active site
281310001197	metal binding site [ion binding]; metal-binding site
281310001198	glutathione binding site [chemical binding]; other site
281310001199	ribonuclease T; Provisional; Region: PRK05168
281310001200	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
281310001201	active site
281310001202	catalytic site [active]
281310001203	substrate binding site [chemical binding]; other site
281310001204	Predicted permease [General function prediction only]; Region: COG2056
281310001205	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
281310001206	Primosomal replication protein N'' [DNA replication, recombination, and repair]; Region: PriC; COG3923
281310001207	elongation factor P; Validated; Region: PRK00529
281310001208	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
281310001209	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
281310001210	RNA binding site [nucleotide binding]; other site
281310001211	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
281310001212	RNA binding site [nucleotide binding]; other site
281310001213	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
281310001214	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
281310001215	FeS/SAM binding site; other site
281310001216	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
281310001217	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
281310001218	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
281310001219	Recombination protein O N terminal; Region: RecO_N; pfam11967
281310001220	Recombination protein O C terminal; Region: RecO_C; pfam02565
281310001221	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
281310001222	TRAM domain; Region: TRAM; pfam01938
281310001223	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
281310001224	S-adenosylmethionine binding site [chemical binding]; other site
281310001225	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
281310001226	HD domain; Region: HD_4; pfam13328
281310001227	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
281310001228	synthetase active site [active]
281310001229	NTP binding site [chemical binding]; other site
281310001230	metal binding site [ion binding]; metal-binding site
281310001231	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
281310001232	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
281310001233	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
281310001234	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
281310001235	MPT binding site; other site
281310001236	trimer interface [polypeptide binding]; other site
281310001237	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
281310001238	Nitrogen regulatory protein P-II; Region: P-II; smart00938
281310001239	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
281310001240	Domain of unknown function DUF20; Region: UPF0118; pfam01594
281310001241	primosome assembly protein PriA; Validated; Region: PRK05580
281310001242	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
281310001243	ATP binding site [chemical binding]; other site
281310001244	putative Mg++ binding site [ion binding]; other site
281310001245	helicase superfamily c-terminal domain; Region: HELICc; smart00490
281310001246	nucleotide binding region [chemical binding]; other site
281310001247	ATP-binding site [chemical binding]; other site
281310001248	tRNA (guanine-N(7)-)-methyltransferase; Region: TIGR00091
281310001249	hypothetical protein; Provisional; Region: PRK11702
281310001250	ferredoxin-type protein NapF; Region: napF; TIGR00402
281310001251	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
281310001252	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
281310001253	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
281310001254	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
281310001255	Uncharacterized protein involved in formation of periplasmic nitrate reductase [Inorganic ion transport and metabolism]; Region: NapD; COG3062
281310001256	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
281310001257	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
281310001258	[4Fe-4S] binding site [ion binding]; other site
281310001259	molybdopterin cofactor binding site; other site
281310001260	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
281310001261	molybdopterin cofactor binding site; other site
281310001262	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
281310001263	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
281310001264	4Fe-4S binding domain; Region: Fer4_5; pfam12801
281310001265	4Fe-4S binding domain; Region: Fer4_6; pfam12837
281310001266	Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043
281310001267	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
281310001268	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
281310001269	adenylate kinase; Reviewed; Region: adk; PRK00279
281310001270	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
281310001271	AMP-binding site [chemical binding]; other site
281310001272	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
281310001273	muropeptide transporter; Reviewed; Region: ampG; PRK11902
281310001274	AmpG-like permease; Region: 2A0125; TIGR00901
281310001275	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
281310001276	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
281310001277	NAD binding site [chemical binding]; other site
281310001278	homodimer interface [polypeptide binding]; other site
281310001279	active site
281310001280	substrate binding site [chemical binding]; other site
281310001281	Alpha-2,3-sialyltransferase (CST-I); Region: CST-I; pfam06002
281310001282	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
281310001283	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
281310001284	Walker A/P-loop; other site
281310001285	ATP binding site [chemical binding]; other site
281310001286	Q-loop/lid; other site
281310001287	ABC transporter signature motif; other site
281310001288	Walker B; other site
281310001289	D-loop; other site
281310001290	H-loop/switch region; other site
281310001291	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
281310001292	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310001293	dimer interface [polypeptide binding]; other site
281310001294	conserved gate region; other site
281310001295	putative PBP binding loops; other site
281310001296	ABC-ATPase subunit interface; other site
281310001297	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
281310001298	NMT1/THI5 like; Region: NMT1; pfam09084
281310001299	Putative transcription activator [Transcription]; Region: TenA; COG0819
281310001300	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
281310001301	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
281310001302	ABC-ATPase subunit  interface; other site
281310001303	dimer interface [polypeptide binding]; other site
281310001304	putative PBP binding regions; other site
281310001305	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
281310001306	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
281310001307	ABC-ATPase subunit  interface; other site
281310001308	dimer interface [polypeptide binding]; other site
281310001309	putative PBP binding regions; other site
281310001310	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
281310001311	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
281310001312	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
281310001313	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
281310001314	metal binding site [ion binding]; metal-binding site
281310001315	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
281310001316	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
281310001317	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
281310001318	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
281310001319	FeS/SAM binding site; other site
281310001320	TPR repeat; Region: TPR_11; pfam13414
281310001321	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
281310001322	TPR motif; other site
281310001323	binding surface
281310001324	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
281310001325	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
281310001326	non-specific DNA binding site [nucleotide binding]; other site
281310001327	salt bridge; other site
281310001328	sequence-specific DNA binding site [nucleotide binding]; other site
281310001329	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
281310001330	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
281310001331	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
281310001332	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
281310001333	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
281310001334	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
281310001335	dimer interface [polypeptide binding]; other site
281310001336	motif 1; other site
281310001337	active site
281310001338	motif 2; other site
281310001339	motif 3; other site
281310001340	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
281310001341	anticodon binding site; other site
281310001342	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
281310001343	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
281310001344	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2975
281310001345	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
281310001346	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
281310001347	catalytic loop [active]
281310001348	iron binding site [ion binding]; other site
281310001349	chaperone protein HscA; Provisional; Region: hscA; PRK05183
281310001350	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
281310001351	nucleotide binding site [chemical binding]; other site
281310001352	putative NEF/HSP70 interaction site [polypeptide binding]; other site
281310001353	SBD interface [polypeptide binding]; other site
281310001354	Protein of unknown function DUF2625; Region: DUF2625; pfam10946
281310001355	co-chaperone HscB; Provisional; Region: hscB; PRK01773
281310001356	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
281310001357	HSP70 interaction site [polypeptide binding]; other site
281310001358	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
281310001359	iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011
281310001360	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
281310001361	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
281310001362	trimerization site [polypeptide binding]; other site
281310001363	active site
281310001364	cysteine desulfurase; Provisional; Region: PRK14012
281310001365	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
281310001366	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
281310001367	catalytic residue [active]
281310001368	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
281310001369	Rrf2 family protein; Region: rrf2_super; TIGR00738
281310001370	RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050
281310001371	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
281310001372	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
281310001373	ligand binding site [chemical binding]; other site
281310001374	translocation protein TolB; Provisional; Region: tolB; PRK01742
281310001375	TolB amino-terminal domain; Region: TolB_N; pfam04052
281310001376	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
281310001377	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
281310001378	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
281310001379	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
281310001380	TolA C-terminal; Region: TolA; pfam06519
281310001381	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
281310001382	colicin uptake protein TolR; Provisional; Region: PRK11024
281310001383	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
281310001384	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
281310001385	active site
281310001386	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
281310001387	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
281310001388	DEAD_2; Region: DEAD_2; pfam06733
281310001389	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
281310001390	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
281310001391	Glycoprotease family; Region: Peptidase_M22; pfam00814
281310001392	outer membrane lipoprotein, Slp family; Region: slp; TIGR00752
281310001393	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
281310001394	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
281310001395	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
281310001396	acyl-activating enzyme (AAE) consensus motif; other site
281310001397	putative AMP binding site [chemical binding]; other site
281310001398	putative active site [active]
281310001399	putative CoA binding site [chemical binding]; other site
281310001400	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
281310001401	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
281310001402	catalytic site [active]
281310001403	putative active site [active]
281310001404	putative substrate binding site [chemical binding]; other site
281310001405	Helicase and RNase D C-terminal; Region: HRDC; smart00341
281310001406	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
281310001407	GTP-binding protein YchF; Reviewed; Region: PRK09601
281310001408	YchF GTPase; Region: YchF; cd01900
281310001409	G1 box; other site
281310001410	GTP/Mg2+ binding site [chemical binding]; other site
281310001411	Switch I region; other site
281310001412	G2 box; other site
281310001413	Switch II region; other site
281310001414	G3 box; other site
281310001415	G4 box; other site
281310001416	G5 box; other site
281310001417	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
281310001418	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
281310001419	putative active site [active]
281310001420	catalytic residue [active]
281310001421	hypothetical protein; Validated; Region: PRK01777
281310001422	Uncharacterized conserved protein [Function unknown]; Region: COG2850
281310001423	Cupin domain; Region: Cupin_2; cl17218
281310001424	exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237
281310001425	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
281310001426	generic binding surface II; other site
281310001427	generic binding surface I; other site
281310001428	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
281310001429	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
281310001430	dimer interface [polypeptide binding]; other site
281310001431	ADP-ribose binding site [chemical binding]; other site
281310001432	active site
281310001433	nudix motif; other site
281310001434	metal binding site [ion binding]; metal-binding site
281310001435	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
281310001436	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
281310001437	active site
281310001438	metal binding site [ion binding]; metal-binding site
281310001439	hexamer interface [polypeptide binding]; other site
281310001440	conserved hypothetical protein; Region: TIGR00743
281310001441	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
281310001442	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
281310001443	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
281310001444	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
281310001445	DNA binding site [nucleotide binding]
281310001446	active site
281310001447	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
281310001448	putative DNA-binding cleft [nucleotide binding]; other site
281310001449	putative DNA clevage site; other site
281310001450	molecular lever; other site
281310001451	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
281310001452	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
281310001453	Ligand Binding Site [chemical binding]; other site
281310001454	TilS substrate binding domain; Region: TilS; pfam09179
281310001455	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
281310001456	NTHIp0526A; similar to: pyridoxamine kinase, C-terminal fragment
281310001457	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
281310001458	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
281310001459	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
281310001460	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
281310001461	ABC-ATPase subunit  interface; other site
281310001462	dimer interface [polypeptide binding]; other site
281310001463	putative PBP binding regions; other site
281310001464	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
281310001465	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
281310001466	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
281310001467	Peptidase family M23; Region: Peptidase_M23; pfam01551
281310001468	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
281310001469	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
281310001470	Walker A motif; other site
281310001471	ATP binding site [chemical binding]; other site
281310001472	Walker B motif; other site
281310001473	arginine finger; other site
281310001474	bacterial Hfq-like; Region: Hfq; cd01716
281310001475	hexamer interface [polypeptide binding]; other site
281310001476	Sm1 motif; other site
281310001477	RNA binding site [nucleotide binding]; other site
281310001478	Sm2 motif; other site
281310001479	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
281310001480	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
281310001481	RNA binding surface [nucleotide binding]; other site
281310001482	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
281310001483	active site
281310001484	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
281310001485	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
281310001486	homodimer interface [polypeptide binding]; other site
281310001487	oligonucleotide binding site [chemical binding]; other site
281310001488	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
281310001489	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
281310001490	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
281310001491	substrate binding site [chemical binding]; other site
281310001492	multimerization interface [polypeptide binding]; other site
281310001493	ATP binding site [chemical binding]; other site
281310001494	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
281310001495	dimer interface [polypeptide binding]; other site
281310001496	substrate binding site [chemical binding]; other site
281310001497	ATP binding site [chemical binding]; other site
281310001498	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
281310001499	thiamine phosphate binding site [chemical binding]; other site
281310001500	active site
281310001501	pyrophosphate binding site [ion binding]; other site
281310001502	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
281310001503	metabolite-proton symporter; Region: 2A0106; TIGR00883
281310001504	putative substrate translocation pore; other site
281310001505	putative protease; Provisional; Region: PRK15452
281310001506	Peptidase family U32; Region: Peptidase_U32; pfam01136
281310001507	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
281310001508	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
281310001509	ATP binding site [chemical binding]; other site
281310001510	Mg++ binding site [ion binding]; other site
281310001511	motif III; other site
281310001512	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
281310001513	nucleotide binding region [chemical binding]; other site
281310001514	ATP-binding site [chemical binding]; other site
281310001515	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
281310001516	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
281310001517	NTHIp0548A; similar to: conserved hypothetical tRNA/rRNA methyltransferase, N-terminal fragment
281310001518	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
281310001519	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
281310001520	domain interface [polypeptide binding]; other site
281310001521	putative active site [active]
281310001522	catalytic site [active]
281310001523	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
281310001524	domain interface [polypeptide binding]; other site
281310001525	putative active site [active]
281310001526	catalytic site [active]
281310001527	fatty acid metabolism transcriptional regulator FadR; Region: fadR_gamma; TIGR02812
281310001528	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
281310001529	DNA-binding site [nucleotide binding]; DNA binding site
281310001530	FadR C-terminal domain; Region: FadR_C; pfam07840
281310001531	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
281310001532	disulfide bond formation protein B; Provisional; Region: PRK01749
281310001533	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
281310001534	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
281310001535	glutaminase active site [active]
281310001536	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
281310001537	dimer interface [polypeptide binding]; other site
281310001538	active site
281310001539	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
281310001540	dimer interface [polypeptide binding]; other site
281310001541	active site
281310001542	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
281310001543	IHF dimer interface [polypeptide binding]; other site
281310001544	IHF - DNA interface [nucleotide binding]; other site
281310001545	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
281310001546	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
281310001547	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
281310001548	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
281310001549	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
281310001550	putative NADH binding site [chemical binding]; other site
281310001551	putative active site [active]
281310001552	nudix motif; other site
281310001553	putative metal binding site [ion binding]; other site
281310001554	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
281310001555	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
281310001556	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
281310001557	comF family protein; Region: comF; TIGR00201
281310001558	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
281310001559	active site
281310001560	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
281310001561	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
281310001562	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
281310001563	Pilus assembly protein, PilP; Region: PilP; pfam04351
281310001564	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
281310001565	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
281310001566	Transglycosylase; Region: Transgly; pfam00912
281310001567	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
281310001568	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
281310001569	hypothetical protein; Validated; Region: PRK00153
281310001570	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353
281310001571	RecR protein; Region: RecR; pfam02132
281310001572	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
281310001573	putative active site [active]
281310001574	putative metal-binding site [ion binding]; other site
281310001575	tetramer interface [polypeptide binding]; other site
281310001576	DNA topoisomerase III; Provisional; Region: PRK07726
281310001577	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
281310001578	active site
281310001579	putative interdomain interaction site [polypeptide binding]; other site
281310001580	putative metal-binding site [ion binding]; other site
281310001581	putative nucleotide binding site [chemical binding]; other site
281310001582	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
281310001583	domain I; other site
281310001584	DNA binding groove [nucleotide binding]
281310001585	phosphate binding site [ion binding]; other site
281310001586	domain II; other site
281310001587	domain III; other site
281310001588	nucleotide binding site [chemical binding]; other site
281310001589	catalytic site [active]
281310001590	domain IV; other site
281310001591	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
281310001592	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
281310001593	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
281310001594	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
281310001595	active site
281310001596	P-loop; other site
281310001597	phosphorylation site [posttranslational modification]
281310001598	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
281310001599	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
281310001600	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
281310001601	putative substrate binding site [chemical binding]; other site
281310001602	putative ATP binding site [chemical binding]; other site
281310001603	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK13779
281310001604	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
281310001605	active site
281310001606	phosphorylation site [posttranslational modification]
281310001607	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
281310001608	dimerization domain swap beta strand [polypeptide binding]; other site
281310001609	regulatory protein interface [polypeptide binding]; other site
281310001610	active site
281310001611	regulatory phosphorylation site [posttranslational modification]; other site
281310001612	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
281310001613	dimerization domain swap beta strand [polypeptide binding]; other site
281310001614	regulatory protein interface [polypeptide binding]; other site
281310001615	active site
281310001616	regulatory phosphorylation site [posttranslational modification]; other site
281310001617	Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309
281310001618	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
281310001619	Domain of unknown function DUF21; Region: DUF21; pfam01595
281310001620	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
281310001621	Transporter associated domain; Region: CorC_HlyC; smart01091
281310001622	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
281310001623	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
281310001624	active site
281310001625	DNA polymerase III subunit delta'; Validated; Region: PRK06871
281310001626	DNA polymerase III subunit delta'; Validated; Region: PRK08485
281310001627	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
281310001628	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253
281310001629	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
281310001630	Autotransporter beta-domain; Region: Autotransporter; pfam03797
281310001631	thymidylate kinase; Validated; Region: tmk; PRK00698
281310001632	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
281310001633	TMP-binding site; other site
281310001634	ATP-binding site [chemical binding]; other site
281310001635	conserved hypothetical protein, YceG family; Region: TIGR00247
281310001636	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
281310001637	dimerization interface [polypeptide binding]; other site
281310001638	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
281310001639	SurA N-terminal domain; Region: SurA_N; pfam09312
281310001640	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
281310001641	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
281310001642	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
281310001643	active site
281310001644	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
281310001645	homodimer interface [polypeptide binding]; other site
281310001646	MazG family protein; Region: mazG; TIGR00444
281310001647	metal binding site [ion binding]; metal-binding site
281310001648	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
281310001649	homodimer interface [polypeptide binding]; other site
281310001650	active site
281310001651	putative chemical substrate binding site [chemical binding]; other site
281310001652	metal binding site [ion binding]; metal-binding site
281310001653	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
281310001654	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
281310001655	Found in ATP-dependent protease La (LON); Region: LON; smart00464
281310001656	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
281310001657	Walker A motif; other site
281310001658	ATP binding site [chemical binding]; other site
281310001659	Walker B motif; other site
281310001660	arginine finger; other site
281310001661	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
281310001662	HemN family oxidoreductase; Provisional; Region: PRK05660
281310001663	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
281310001664	FeS/SAM binding site; other site
281310001665	HemN C-terminal domain; Region: HemN_C; pfam06969
281310001666	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
281310001667	tetramer (dimer of dimers) interface [polypeptide binding]; other site
281310001668	active site
281310001669	dimer interface [polypeptide binding]; other site
281310001670	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
281310001671	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
281310001672	ligand binding site [chemical binding]; other site
281310001673	NAD binding site [chemical binding]; other site
281310001674	tetramer interface [polypeptide binding]; other site
281310001675	catalytic site [active]
281310001676	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
281310001677	L-serine binding site [chemical binding]; other site
281310001678	ACT domain interface; other site
281310001679	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
281310001680	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
281310001681	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
281310001682	hypothetical protein; Provisional; Region: PRK11820
281310001683	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
281310001684	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
281310001685	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
281310001686	ATP phosphoribosyltransferase; Region: HisG; pfam01634
281310001687	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
281310001688	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
281310001689	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
281310001690	NAD binding site [chemical binding]; other site
281310001691	dimerization interface [polypeptide binding]; other site
281310001692	product binding site; other site
281310001693	substrate binding site [chemical binding]; other site
281310001694	zinc binding site [ion binding]; other site
281310001695	catalytic residues [active]
281310001696	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
281310001697	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
281310001698	pyridoxal 5'-phosphate binding site [chemical binding]; other site
281310001699	homodimer interface [polypeptide binding]; other site
281310001700	catalytic residue [active]
281310001701	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
281310001702	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
281310001703	active site
281310001704	motif I; other site
281310001705	motif II; other site
281310001706	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
281310001707	putative active site pocket [active]
281310001708	4-fold oligomerization interface [polypeptide binding]; other site
281310001709	metal binding residues [ion binding]; metal-binding site
281310001710	3-fold/trimer interface [polypeptide binding]; other site
281310001711	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
281310001712	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
281310001713	putative active site [active]
281310001714	oxyanion strand; other site
281310001715	catalytic triad [active]
281310001716	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
281310001717	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
281310001718	catalytic residues [active]
281310001719	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
281310001720	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
281310001721	substrate binding site [chemical binding]; other site
281310001722	glutamase interaction surface [polypeptide binding]; other site
281310001723	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
281310001724	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
281310001725	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
281310001726	metal binding site [ion binding]; metal-binding site
281310001727	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222
281310001728	aromatic amino acid transport protein; Region: araaP; TIGR00837
281310001729	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
281310001730	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
281310001731	gamma subunit interface [polypeptide binding]; other site
281310001732	epsilon subunit interface [polypeptide binding]; other site
281310001733	LBP interface [polypeptide binding]; other site
281310001734	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
281310001735	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
281310001736	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
281310001737	alpha subunit interaction interface [polypeptide binding]; other site
281310001738	Walker A motif; other site
281310001739	ATP binding site [chemical binding]; other site
281310001740	Walker B motif; other site
281310001741	inhibitor binding site; inhibition site
281310001742	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
281310001743	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
281310001744	core domain interface [polypeptide binding]; other site
281310001745	delta subunit interface [polypeptide binding]; other site
281310001746	epsilon subunit interface [polypeptide binding]; other site
281310001747	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
281310001748	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
281310001749	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
281310001750	beta subunit interaction interface [polypeptide binding]; other site
281310001751	Walker A motif; other site
281310001752	ATP binding site [chemical binding]; other site
281310001753	Walker B motif; other site
281310001754	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
281310001755	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
281310001756	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
281310001757	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
281310001758	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
281310001759	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
281310001760	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
281310001761	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
281310001762	F0F1 ATP synthase subunit I; Validated; Region: PRK06099
281310001763	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
281310001764	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
281310001765	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
281310001766	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
281310001767	motif II; other site
281310001768	Predicted membrane protein [Function unknown]; Region: COG1238
281310001769	S-ribosylhomocysteinase; Provisional; Region: PRK02260
281310001770	acid phosphatase/phosphotransferase; Provisional; Region: aphA; PRK11009
281310001771	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
281310001772	HslU subunit interaction site [polypeptide binding]; other site
281310001773	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
281310001774	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
281310001775	Walker A motif; other site
281310001776	ATP binding site [chemical binding]; other site
281310001777	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
281310001778	Walker B motif; other site
281310001779	arginine finger; other site
281310001780	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
281310001781	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
281310001782	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
281310001783	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
281310001784	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
281310001785	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
281310001786	RmuC family; Region: RmuC; pfam02646
281310001787	D-ribose pyranase; Provisional; Region: PRK11797
281310001788	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
281310001789	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
281310001790	Walker A/P-loop; other site
281310001791	ATP binding site [chemical binding]; other site
281310001792	Q-loop/lid; other site
281310001793	ABC transporter signature motif; other site
281310001794	Walker B; other site
281310001795	D-loop; other site
281310001796	H-loop/switch region; other site
281310001797	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
281310001798	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
281310001799	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
281310001800	TM-ABC transporter signature motif; other site
281310001801	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
281310001802	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
281310001803	ligand binding site [chemical binding]; other site
281310001804	dimerization interface [polypeptide binding]; other site
281310001805	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
281310001806	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
281310001807	substrate binding site [chemical binding]; other site
281310001808	dimer interface [polypeptide binding]; other site
281310001809	ATP binding site [chemical binding]; other site
281310001810	transcriptional repressor RbsR; Provisional; Region: PRK10423
281310001811	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
281310001812	DNA binding site [nucleotide binding]
281310001813	domain linker motif; other site
281310001814	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
281310001815	dimerization interface [polypeptide binding]; other site
281310001816	ligand binding site [chemical binding]; other site
281310001817	hypothetical protein; Provisional; Region: PRK05208
281310001818	regulator of ribonuclease activity A; Region: RraA_entero; TIGR02998
281310001819	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751
281310001820	UbiA prenyltransferase family; Region: UbiA; pfam01040
281310001821	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
281310001822	homodimer interaction site [polypeptide binding]; other site
281310001823	cofactor binding site; other site
281310001824	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
281310001825	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
281310001826	gating phenylalanine in ion channel; other site
281310001827	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
281310001828	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
281310001829	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
281310001830	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
281310001831	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
281310001832	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
281310001833	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
281310001834	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
281310001835	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
281310001836	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
281310001837	DNA binding site [nucleotide binding]
281310001838	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
281310001839	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
281310001840	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
281310001841	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
281310001842	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
281310001843	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
281310001844	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
281310001845	RPB1 interaction site [polypeptide binding]; other site
281310001846	RPB11 interaction site [polypeptide binding]; other site
281310001847	RPB10 interaction site [polypeptide binding]; other site
281310001848	RPB3 interaction site [polypeptide binding]; other site
281310001849	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
281310001850	mRNA/rRNA interface [nucleotide binding]; other site
281310001851	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
281310001852	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
281310001853	23S rRNA interface [nucleotide binding]; other site
281310001854	L7/L12 interface [polypeptide binding]; other site
281310001855	putative thiostrepton binding site; other site
281310001856	L25 interface [polypeptide binding]; other site
281310001857	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
281310001858	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
281310001859	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
281310001860	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
281310001861	Nucleoside recognition; Region: Gate; pfam07670
281310001862	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
281310001863	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
281310001864	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
281310001865	FeS/SAM binding site; other site
281310001866	glycine radical enzyme, YjjI family; Region: glycyl_YjjI; TIGR04040
281310001867	Pyruvate formate lyase; Region: PFL; pfam02901
281310001868	Predicted membrane protein [Function unknown]; Region: COG2364
281310001869	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
281310001870	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
281310001871	putative active site [active]
281310001872	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
281310001873	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
281310001874	active site
281310001875	intersubunit interface [polypeptide binding]; other site
281310001876	zinc binding site [ion binding]; other site
281310001877	Na+ binding site [ion binding]; other site
281310001878	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
281310001879	Phosphoglycerate kinase; Region: PGK; pfam00162
281310001880	substrate binding site [chemical binding]; other site
281310001881	hinge regions; other site
281310001882	ADP binding site [chemical binding]; other site
281310001883	catalytic site [active]
281310001884	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
281310001885	B1 nucleotide binding pocket [chemical binding]; other site
281310001886	B2 nucleotide binding pocket [chemical binding]; other site
281310001887	CAS motifs; other site
281310001888	active site
281310001889	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
281310001890	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222
281310001891	aromatic amino acid transport protein; Region: araaP; TIGR00837
281310001892	thymidine kinase; Provisional; Region: PRK04296
281310001893	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
281310001894	ATP binding site [chemical binding]; other site
281310001895	Walker A motif; other site
281310001896	Walker B motif; other site
281310001897	UGMP family protein; Validated; Region: PRK09604
281310001898	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
281310001899	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
281310001900	DNA primase; Validated; Region: dnaG; PRK05667
281310001901	CHC2 zinc finger; Region: zf-CHC2; pfam01807
281310001902	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
281310001903	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
281310001904	active site
281310001905	metal binding site [ion binding]; metal-binding site
281310001906	interdomain interaction site; other site
281310001907	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
281310001908	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
281310001909	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
281310001910	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
281310001911	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
281310001912	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
281310001913	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
281310001914	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
281310001915	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
281310001916	DNA binding residues [nucleotide binding]
281310001917	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
281310001918	Aspartase; Region: Aspartase; cd01357
281310001919	active sites [active]
281310001920	tetramer interface [polypeptide binding]; other site
281310001921	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
281310001922	urease accessory protein UreG; Region: ureG; TIGR00101
281310001923	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
281310001924	UreF; Region: UreF; pfam01730
281310001925	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
281310001926	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
281310001927	dimer interface [polypeptide binding]; other site
281310001928	catalytic residues [active]
281310001929	urease subunit alpha; Reviewed; Region: ureC; PRK13207
281310001930	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
281310001931	subunit interactions [polypeptide binding]; other site
281310001932	active site
281310001933	flap region; other site
281310001934	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
281310001935	gamma-beta subunit interface [polypeptide binding]; other site
281310001936	alpha-beta subunit interface [polypeptide binding]; other site
281310001937	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
281310001938	alpha-gamma subunit interface [polypeptide binding]; other site
281310001939	beta-gamma subunit interface [polypeptide binding]; other site
281310001940	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
281310001941	oligomerisation interface [polypeptide binding]; other site
281310001942	mobile loop; other site
281310001943	roof hairpin; other site
281310001944	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
281310001945	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
281310001946	ring oligomerisation interface [polypeptide binding]; other site
281310001947	ATP/Mg binding site [chemical binding]; other site
281310001948	stacking interactions; other site
281310001949	hinge regions; other site
281310001950	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
281310001951	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
281310001952	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
281310001953	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
281310001954	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
281310001955	dimer interface [polypeptide binding]; other site
281310001956	ssDNA binding site [nucleotide binding]; other site
281310001957	tetramer (dimer of dimers) interface [polypeptide binding]; other site
281310001958	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
281310001959	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
281310001960	rRNA binding site [nucleotide binding]; other site
281310001961	predicted 30S ribosome binding site; other site
281310001962	NTHIp0675A; similar to: UDP-glucose--lipooligosaccharide glucosyltransferase, N-terminal fragment
281310001963	NTHIp0675B; similar to: UDP-glucose--lipooligosaccharide glucosyltransferase, C-terminal fragment
281310001964	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
281310001965	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
281310001966	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
281310001967	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
281310001968	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
281310001969	active site
281310001970	metal binding site [ion binding]; metal-binding site
281310001971	Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786
281310001972	6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362
281310001973	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
281310001974	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
281310001975	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
281310001976	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
281310001977	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
281310001978	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
281310001979	putative active site [active]
281310001980	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
281310001981	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
281310001982	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
281310001983	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
281310001984	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
281310001985	active site
281310001986	Predicted membrane protein [Function unknown]; Region: COG1297
281310001987	putative oligopeptide transporter, OPT family; Region: TIGR00733
281310001988	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
281310001989	RNA binding surface [nucleotide binding]; other site
281310001990	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
281310001991	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
281310001992	dimerization interface [polypeptide binding]; other site
281310001993	putative DNA binding site [nucleotide binding]; other site
281310001994	putative Zn2+ binding site [ion binding]; other site
281310001995	AsnC family; Region: AsnC_trans_reg; pfam01037
281310001996	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
281310001997	dimer interface [polypeptide binding]; other site
281310001998	active site
281310001999	Integrase core domain; Region: rve; pfam00665
281310002000	Integrase core domain; Region: rve_2; pfam13333
281310002001	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
281310002002	phosphoglycolate phosphatase; Provisional; Region: PRK13222
281310002003	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
281310002004	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
281310002005	motif II; other site
281310002006	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
281310002007	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
281310002008	substrate binding site [chemical binding]; other site
281310002009	hexamer interface [polypeptide binding]; other site
281310002010	metal binding site [ion binding]; metal-binding site
281310002011	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
281310002012	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
281310002013	ATP binding site [chemical binding]; other site
281310002014	Mg2+ binding site [ion binding]; other site
281310002015	G-X-G motif; other site
281310002016	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
281310002017	anchoring element; other site
281310002018	dimer interface [polypeptide binding]; other site
281310002019	ATP binding site [chemical binding]; other site
281310002020	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
281310002021	active site
281310002022	putative metal-binding site [ion binding]; other site
281310002023	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
281310002024	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
281310002025	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
281310002026	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
281310002027	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
281310002028	RNA binding site [nucleotide binding]; other site
281310002029	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
281310002030	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
281310002031	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
281310002032	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
281310002033	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
281310002034	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
281310002035	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
281310002036	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
281310002037	dimerization interface [polypeptide binding]; other site
281310002038	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
281310002039	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
281310002040	catalytic triad [active]
281310002041	dimer interface [polypeptide binding]; other site
281310002042	Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029
281310002043	GSH binding site [chemical binding]; other site
281310002044	catalytic residues [active]
281310002045	hypothetical protein; Provisional; Region: PRK02119
281310002046	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
281310002047	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
281310002048	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
281310002049	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
281310002050	YheO-like PAS domain; Region: PAS_6; pfam08348
281310002051	HTH domain; Region: HTH_22; pfam13309
281310002052	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
281310002053	sulfur relay protein TusC; Validated; Region: PRK00211
281310002054	Uncharacterized conserved protein involved in oxidation of intracellular sulfur [Inorganic ion transport and metabolism]; Region: DsrH; COG2168
281310002055	elongation factor Tu; Reviewed; Region: PRK00049
281310002056	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
281310002057	G1 box; other site
281310002058	GEF interaction site [polypeptide binding]; other site
281310002059	GTP/Mg2+ binding site [chemical binding]; other site
281310002060	Switch I region; other site
281310002061	G2 box; other site
281310002062	G3 box; other site
281310002063	Switch II region; other site
281310002064	G4 box; other site
281310002065	G5 box; other site
281310002066	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
281310002067	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
281310002068	Antibiotic Binding Site [chemical binding]; other site
281310002069	pantothenate kinase; Provisional; Region: PRK05439
281310002070	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
281310002071	ATP-binding site [chemical binding]; other site
281310002072	CoA-binding site [chemical binding]; other site
281310002073	Mg2+-binding site [ion binding]; other site
281310002074	anti-sigma E factor; Provisional; Region: rseB; PRK09455
281310002075	MucB/RseB family; Region: MucB_RseB; pfam03888
281310002076	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
281310002077	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
281310002078	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
281310002079	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
281310002080	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
281310002081	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
281310002082	DNA binding residues [nucleotide binding]
281310002083	Uncharacterized conserved protein [Function unknown]; Region: COG2938
281310002084	Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741
281310002085	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
281310002086	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
281310002087	TrkA-N domain; Region: TrkA_N; pfam02254
281310002088	TrkA-C domain; Region: TrkA_C; pfam02080
281310002089	TrkA-N domain; Region: TrkA_N; pfam02254
281310002090	TrkA-C domain; Region: TrkA_C; pfam02080
281310002091	16S rRNA methyltransferase B; Provisional; Region: PRK10901
281310002092	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
281310002093	putative RNA binding site [nucleotide binding]; other site
281310002094	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
281310002095	S-adenosylmethionine binding site [chemical binding]; other site
281310002096	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
281310002097	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
281310002098	putative active site [active]
281310002099	substrate binding site [chemical binding]; other site
281310002100	putative cosubstrate binding site; other site
281310002101	catalytic site [active]
281310002102	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
281310002103	substrate binding site [chemical binding]; other site
281310002104	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
281310002105	active site
281310002106	catalytic residues [active]
281310002107	metal binding site [ion binding]; metal-binding site
281310002108	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
281310002109	rRNA operon region 3; NTHIpnote0009
281310002110	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
281310002111	TfoX C-terminal domain; Region: TfoX_C; pfam04994
281310002112	recombinase A; Provisional; Region: recA; PRK09354
281310002113	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
281310002114	hexamer interface [polypeptide binding]; other site
281310002115	Walker A motif; other site
281310002116	ATP binding site [chemical binding]; other site
281310002117	Walker B motif; other site
281310002118	recombination regulator RecX; Reviewed; Region: recX; PRK00117
281310002119	chromosome condensation membrane protein; Provisional; Region: PRK14196
281310002120	putative hydrolase; Provisional; Region: PRK10976
281310002121	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
281310002122	active site
281310002123	motif I; other site
281310002124	motif II; other site
281310002125	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
281310002126	ornithine carbamoyltransferase; Provisional; Region: PRK01713
281310002127	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
281310002128	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
281310002129	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
281310002130	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
281310002131	putative substrate binding site [chemical binding]; other site
281310002132	nucleotide binding site [chemical binding]; other site
281310002133	nucleotide binding site [chemical binding]; other site
281310002134	homodimer interface [polypeptide binding]; other site
281310002135	Predicted membrane protein [Function unknown]; Region: COG1288
281310002136	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
281310002137	NTHIp0736A; similar to: hemoglobin-haptoglobin binding protein D, N-terminal fragment
281310002138	NTHIp0736B; similar to: hemoglobin-haptoglobin binding protein D, C-terminal fragment
281310002139	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
281310002140	active site pocket [active]
281310002141	oxyanion hole [active]
281310002142	catalytic triad [active]
281310002143	active site nucleophile [active]
281310002144	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069
281310002145	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
281310002146	M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665
281310002147	putative metal binding site [ion binding]; other site
281310002148	dimer interface [polypeptide binding]; other site
281310002149	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
281310002150	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
281310002151	active site
281310002152	metal binding site [ion binding]; metal-binding site
281310002153	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
281310002154	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
281310002155	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
281310002156	DNA binding residues [nucleotide binding]
281310002157	dimer interface [polypeptide binding]; other site
281310002158	putative metal binding site [ion binding]; other site
281310002159	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
281310002160	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
281310002161	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
281310002162	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
281310002163	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
281310002164	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
281310002165	S17 interaction site [polypeptide binding]; other site
281310002166	S8 interaction site; other site
281310002167	16S rRNA interaction site [nucleotide binding]; other site
281310002168	streptomycin interaction site [chemical binding]; other site
281310002169	23S rRNA interaction site [nucleotide binding]; other site
281310002170	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
281310002171	30S ribosomal protein S7; Validated; Region: PRK05302
281310002172	elongation factor G; Reviewed; Region: PRK00007
281310002173	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
281310002174	G1 box; other site
281310002175	putative GEF interaction site [polypeptide binding]; other site
281310002176	GTP/Mg2+ binding site [chemical binding]; other site
281310002177	Switch I region; other site
281310002178	G2 box; other site
281310002179	G3 box; other site
281310002180	Switch II region; other site
281310002181	G4 box; other site
281310002182	G5 box; other site
281310002183	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
281310002184	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
281310002185	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
281310002186	elongation factor Tu; Reviewed; Region: PRK00049
281310002187	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
281310002188	G1 box; other site
281310002189	GEF interaction site [polypeptide binding]; other site
281310002190	GTP/Mg2+ binding site [chemical binding]; other site
281310002191	Switch I region; other site
281310002192	G2 box; other site
281310002193	G3 box; other site
281310002194	Switch II region; other site
281310002195	G4 box; other site
281310002196	G5 box; other site
281310002197	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
281310002198	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
281310002199	Antibiotic Binding Site [chemical binding]; other site
281310002200	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
281310002201	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
281310002202	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
281310002203	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
281310002204	FMN binding site [chemical binding]; other site
281310002205	active site
281310002206	catalytic residues [active]
281310002207	substrate binding site [chemical binding]; other site
281310002208	conserved hypothetical protein; Region: TIGR00743
281310002209	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
281310002210	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
281310002211	active site
281310002212	HIGH motif; other site
281310002213	dimer interface [polypeptide binding]; other site
281310002214	KMSKS motif; other site
281310002215	Uncharacterized protein involved in purine metabolism [General function prediction only]; Region: COG2915
281310002216	adenylosuccinate lyase; Provisional; Region: PRK09285
281310002217	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
281310002218	tetramer interface [polypeptide binding]; other site
281310002219	active site
281310002220	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
281310002221	23S rRNA interface [nucleotide binding]; other site
281310002222	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
281310002223	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
281310002224	core dimer interface [polypeptide binding]; other site
281310002225	peripheral dimer interface [polypeptide binding]; other site
281310002226	L10 interface [polypeptide binding]; other site
281310002227	L11 interface [polypeptide binding]; other site
281310002228	putative EF-Tu interaction site [polypeptide binding]; other site
281310002229	putative EF-G interaction site [polypeptide binding]; other site
281310002230	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
281310002231	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
281310002232	Substrate binding site; other site
281310002233	Mg++ binding site; other site
281310002234	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
281310002235	active site
281310002236	substrate binding site [chemical binding]; other site
281310002237	CoA binding site [chemical binding]; other site
281310002238	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
281310002239	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
281310002240	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
281310002241	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
281310002242	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
281310002243	MgtC family; Region: MgtC; pfam02308
281310002244	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
281310002245	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
281310002246	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
281310002247	Part of AAA domain; Region: AAA_19; pfam13245
281310002248	Family description; Region: UvrD_C_2; pfam13538
281310002249	Protein of unknown function (DUF1375); Region: DUF1375; cl11456
281310002250	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
281310002251	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
281310002252	active site
281310002253	(T/H)XGH motif; other site
281310002254	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
281310002255	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
281310002256	Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534
281310002257	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
281310002258	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
281310002259	putative metal binding site; other site
281310002260	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
281310002261	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
281310002262	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
281310002263	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
281310002264	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
281310002265	shikimate binding site; other site
281310002266	NAD(P) binding site [chemical binding]; other site
281310002267	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
281310002268	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
281310002269	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
281310002270	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
281310002271	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
281310002272	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
281310002273	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
281310002274	Walker A/P-loop; other site
281310002275	ATP binding site [chemical binding]; other site
281310002276	Q-loop/lid; other site
281310002277	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
281310002278	ABC transporter; Region: ABC_tran_2; pfam12848
281310002279	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
281310002280	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
281310002281	non-specific DNA binding site [nucleotide binding]; other site
281310002282	salt bridge; other site
281310002283	sequence-specific DNA binding site [nucleotide binding]; other site
281310002284	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
281310002285	TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776
281310002286	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
281310002287	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
281310002288	ligand-binding site [chemical binding]; other site
281310002289	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
281310002290	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
281310002291	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
281310002292	Walker A/P-loop; other site
281310002293	ATP binding site [chemical binding]; other site
281310002294	Q-loop/lid; other site
281310002295	ABC transporter signature motif; other site
281310002296	Walker B; other site
281310002297	D-loop; other site
281310002298	H-loop/switch region; other site
281310002299	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
281310002300	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
281310002301	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
281310002302	Walker A/P-loop; other site
281310002303	ATP binding site [chemical binding]; other site
281310002304	Q-loop/lid; other site
281310002305	ABC transporter signature motif; other site
281310002306	Walker B; other site
281310002307	D-loop; other site
281310002308	H-loop/switch region; other site
281310002309	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
281310002310	HipA-like N-terminal domain; Region: HipA_N; pfam07805
281310002311	HipA-like C-terminal domain; Region: HipA_C; pfam07804
281310002312	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
281310002313	HipA N-terminal domain; Region: Couple_hipA; pfam13657
281310002314	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
281310002315	non-specific DNA binding site [nucleotide binding]; other site
281310002316	salt bridge; other site
281310002317	sequence-specific DNA binding site [nucleotide binding]; other site
281310002318	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
281310002319	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
281310002320	putative active site [active]
281310002321	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074
281310002322	FMN-binding protein MioC; Provisional; Region: PRK09004
281310002323	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
281310002324	putative active site [active]
281310002325	dimerization interface [polypeptide binding]; other site
281310002326	putative tRNAtyr binding site [nucleotide binding]; other site
281310002327	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
281310002328	homotrimer interaction site [polypeptide binding]; other site
281310002329	zinc binding site [ion binding]; other site
281310002330	CDP-binding sites; other site
281310002331	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
281310002332	substrate binding site; other site
281310002333	dimer interface; other site
281310002334	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
281310002335	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
281310002336	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
281310002337	active site
281310002338	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
281310002339	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
281310002340	metal binding site [ion binding]; metal-binding site
281310002341	dimer interface [polypeptide binding]; other site
281310002342	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
281310002343	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
281310002344	active site
281310002345	Int/Topo IB signature motif; other site
281310002346	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
281310002347	triosephosphate isomerase; Provisional; Region: PRK14567
281310002348	substrate binding site [chemical binding]; other site
281310002349	dimer interface [polypeptide binding]; other site
281310002350	catalytic triad [active]
281310002351	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
281310002352	active site residue [active]
281310002353	rarD protein; Region: rarD; TIGR00688
281310002354	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
281310002355	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
281310002356	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
281310002357	putative dimerization interface [polypeptide binding]; other site
281310002358	ketol-acid reductoisomerase; Validated; Region: PRK05225
281310002359	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
281310002360	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
281310002361	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
281310002362	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
281310002363	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
281310002364	Cysteine-rich domain; Region: CCG; pfam02754
281310002365	Cysteine-rich domain; Region: CCG; pfam02754
281310002366	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
281310002367	glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378
281310002368	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
281310002369	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
281310002370	glycerol-3-phosphate transporter; Region: glpT; TIGR00712
281310002371	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
281310002372	putative substrate translocation pore; other site
281310002373	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
281310002374	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
281310002375	active site
281310002376	catalytic site [active]
281310002377	metal binding site [ion binding]; metal-binding site
281310002378	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
281310002379	amphipathic channel; other site
281310002380	Asn-Pro-Ala signature motifs; other site
281310002381	glycerol kinase; Provisional; Region: glpK; PRK00047
281310002382	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
281310002383	N- and C-terminal domain interface [polypeptide binding]; other site
281310002384	active site
281310002385	MgATP binding site [chemical binding]; other site
281310002386	catalytic site [active]
281310002387	metal binding site [ion binding]; metal-binding site
281310002388	glycerol binding site [chemical binding]; other site
281310002389	homotetramer interface [polypeptide binding]; other site
281310002390	homodimer interface [polypeptide binding]; other site
281310002391	FBP binding site [chemical binding]; other site
281310002392	protein IIAGlc interface [polypeptide binding]; other site
281310002393	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
281310002394	active site
281310002395	NTHIp0815A; similar to: glycerophosphoryl diester phosphodiesterase precursor, C-terminal fragment
281310002396	Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503
281310002397	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
281310002398	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
281310002399	probable active site [active]
281310002400	NTHIp0818B; similar to:  exopolyphosphatase, C-terminal fragment
281310002401	NTHIp0818A; similar to:  exopolyphosphatase, N-terminal fragment
281310002402	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
281310002403	Family of unknown function (DUF490); Region: DUF490; pfam04357
281310002404	Family of unknown function (DUF490); Region: DUF490; pfam04357
281310002405	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
281310002406	Surface antigen; Region: Bac_surface_Ag; pfam01103
281310002407	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737
281310002408	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
281310002409	RNase E inhibitor protein; Provisional; Region: PRK11191
281310002410	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
281310002411	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
281310002412	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
281310002413	Permutation of conserved domain; other site
281310002414	active site
281310002415	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
281310002416	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
281310002417	Predicted membrane protein [Function unknown]; Region: COG1238
281310002418	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
281310002419	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
281310002420	Peptidase family M23; Region: Peptidase_M23; pfam01551
281310002421	tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617
281310002422	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
281310002423	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
281310002424	catalytic residue [active]
281310002425	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222
281310002426	aromatic amino acid transport protein; Region: araaP; TIGR00837
281310002427	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
281310002428	MutS domain I; Region: MutS_I; pfam01624
281310002429	MutS domain II; Region: MutS_II; pfam05188
281310002430	MutS domain III; Region: MutS_III; pfam05192
281310002431	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
281310002432	Walker A/P-loop; other site
281310002433	ATP binding site [chemical binding]; other site
281310002434	Q-loop/lid; other site
281310002435	ABC transporter signature motif; other site
281310002436	Walker B; other site
281310002437	D-loop; other site
281310002438	H-loop/switch region; other site
281310002439	selenocysteine synthase; Provisional; Region: PRK04311
281310002440	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
281310002441	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
281310002442	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
281310002443	catalytic residue [active]
281310002444	selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475
281310002445	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
281310002446	G1 box; other site
281310002447	putative GEF interaction site [polypeptide binding]; other site
281310002448	GTP/Mg2+ binding site [chemical binding]; other site
281310002449	Switch I region; other site
281310002450	G2 box; other site
281310002451	G3 box; other site
281310002452	Switch II region; other site
281310002453	G4 box; other site
281310002454	G5 box; other site
281310002455	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
281310002456	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
281310002457	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
281310002458	DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cl02442
281310002459	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
281310002460	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
281310002461	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
281310002462	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
281310002463	RelB antitoxin; Region: RelB; pfam04221
281310002464	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
281310002465	NTHIp0840B; similar to: hemoglobin-haptoglobin binding protein C, C-terminal fragment
281310002466	NTHIp0840A; similar to: hemoglobin-haptoglobin binding protein C, N-terminal fragment
281310002467	trigger factor; Provisional; Region: tig; PRK01490
281310002468	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
281310002469	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
281310002470	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
281310002471	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
281310002472	oligomer interface [polypeptide binding]; other site
281310002473	active site residues [active]
281310002474	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
281310002475	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
281310002476	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
281310002477	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
281310002478	Walker A motif; other site
281310002479	ATP binding site [chemical binding]; other site
281310002480	Walker B motif; other site
281310002481	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
281310002482	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
281310002483	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
281310002484	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
281310002485	putative homodimer interface [polypeptide binding]; other site
281310002486	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
281310002487	heterodimer interface [polypeptide binding]; other site
281310002488	homodimer interface [polypeptide binding]; other site
281310002489	Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853
281310002490	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
281310002491	homotrimer interaction site [polypeptide binding]; other site
281310002492	putative active site [active]
281310002493	heat shock protein HtpX; Provisional; Region: PRK05457
281310002494	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
281310002495	CPxP  motif; other site
281310002496	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
281310002497	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
281310002498	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
281310002499	Cation transport protein; Region: TrkH; cl17365
281310002500	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
281310002501	rRNA operon region 4; NTHIpnote0013
281310002502	Predicted membrane protein [Function unknown]; Region: COG3223
281310002503	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
281310002504	HemY protein N-terminus; Region: HemY_N; pfam07219
281310002505	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
281310002506	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
281310002507	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
281310002508	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
281310002509	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
281310002510	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
281310002511	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
281310002512	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
281310002513	serine acetyltransferase; Provisional; Region: cysE; PRK11132
281310002514	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
281310002515	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
281310002516	trimer interface [polypeptide binding]; other site
281310002517	active site
281310002518	substrate binding site [chemical binding]; other site
281310002519	CoA binding site [chemical binding]; other site
281310002520	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
281310002521	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
281310002522	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
281310002523	shikimate binding site; other site
281310002524	NAD(P) binding site [chemical binding]; other site
281310002525	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
281310002526	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
281310002527	transmembrane helices; other site
281310002528	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
281310002529	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
281310002530	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
281310002531	homodimer interface [polypeptide binding]; other site
281310002532	NADP binding site [chemical binding]; other site
281310002533	substrate binding site [chemical binding]; other site
281310002534	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
281310002535	L-fucose transporter; Provisional; Region: PRK10133; cl17665
281310002536	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
281310002537	intersubunit interface [polypeptide binding]; other site
281310002538	active site
281310002539	Zn2+ binding site [ion binding]; other site
281310002540	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
281310002541	L-fuculokinase; Region: fuculo_kin_coli; TIGR02628
281310002542	L-fuculose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_FK; cd07773
281310002543	putative N- and C-terminal domain interface [polypeptide binding]; other site
281310002544	putative active site [active]
281310002545	putative MgATP binding site [chemical binding]; other site
281310002546	putative catalytic site [active]
281310002547	metal binding site [ion binding]; metal-binding site
281310002548	putative carbohydrate binding site [chemical binding]; other site
281310002549	L-fucose isomerase; Provisional; Region: fucI; PRK10991
281310002550	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
281310002551	hexamer (dimer of trimers) interface [polypeptide binding]; other site
281310002552	trimer interface [polypeptide binding]; other site
281310002553	substrate binding site [chemical binding]; other site
281310002554	Mn binding site [ion binding]; other site
281310002555	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
281310002556	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
281310002557	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
281310002558	ATP-dependent helicase HepA; Validated; Region: PRK04914
281310002559	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
281310002560	ATP binding site [chemical binding]; other site
281310002561	putative Mg++ binding site [ion binding]; other site
281310002562	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
281310002563	nucleotide binding region [chemical binding]; other site
281310002564	ATP-binding site [chemical binding]; other site
281310002565	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
281310002566	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
281310002567	active site
281310002568	Rhomboid family; Region: Rhomboid; pfam01694
281310002569	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
281310002570	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
281310002571	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
281310002572	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
281310002573	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
281310002574	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310002575	dimer interface [polypeptide binding]; other site
281310002576	conserved gate region; other site
281310002577	ABC-ATPase subunit interface; other site
281310002578	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
281310002579	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
281310002580	Walker A/P-loop; other site
281310002581	ATP binding site [chemical binding]; other site
281310002582	Q-loop/lid; other site
281310002583	ABC transporter signature motif; other site
281310002584	Walker B; other site
281310002585	D-loop; other site
281310002586	H-loop/switch region; other site
281310002587	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
281310002588	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
281310002589	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
281310002590	active site
281310002591	motif I; other site
281310002592	motif II; other site
281310002593	rRNA operon region 5; NTHIpnote0014
281310002594	Der GTPase activator (YihI); Region: YihI; cl01172
281310002595	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
281310002596	transcriptional regulator NarP; Provisional; Region: PRK10403
281310002597	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
281310002598	active site
281310002599	phosphorylation site [posttranslational modification]
281310002600	intermolecular recognition site; other site
281310002601	dimerization interface [polypeptide binding]; other site
281310002602	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
281310002603	DNA binding residues [nucleotide binding]
281310002604	dimerization interface [polypeptide binding]; other site
281310002605	diaminopimelate decarboxylase; Region: lysA; TIGR01048
281310002606	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
281310002607	active site
281310002608	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
281310002609	substrate binding site [chemical binding]; other site
281310002610	catalytic residues [active]
281310002611	dimer interface [polypeptide binding]; other site
281310002612	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
281310002613	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
281310002614	putative iron binding site [ion binding]; other site
281310002615	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
281310002616	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
281310002617	ATP binding site [chemical binding]; other site
281310002618	putative Mg++ binding site [ion binding]; other site
281310002619	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
281310002620	nucleotide binding region [chemical binding]; other site
281310002621	ATP-binding site [chemical binding]; other site
281310002622	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
281310002623	Helicase and RNase D C-terminal; Region: HRDC; smart00341
281310002624	prolyl-tRNA synthetase; Provisional; Region: PRK09194
281310002625	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
281310002626	dimer interface [polypeptide binding]; other site
281310002627	motif 1; other site
281310002628	active site
281310002629	motif 2; other site
281310002630	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
281310002631	putative deacylase active site [active]
281310002632	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
281310002633	active site
281310002634	motif 3; other site
281310002635	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
281310002636	anticodon binding site; other site
281310002637	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
281310002638	OstA-like protein; Region: OstA; pfam03968
281310002639	Organic solvent tolerance protein; Region: OstA_C; pfam04453
281310002640	FtsI repressor; Provisional; Region: PRK10883
281310002641	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
281310002642	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
281310002643	putative acyl-acceptor binding pocket; other site
281310002644	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
281310002645	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
281310002646	putative active site [active]
281310002647	putative metal binding site [ion binding]; other site
281310002648	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
281310002649	Na2 binding site [ion binding]; other site
281310002650	putative substrate binding site 1 [chemical binding]; other site
281310002651	Na binding site 1 [ion binding]; other site
281310002652	putative substrate binding site 2 [chemical binding]; other site
281310002653	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
281310002654	PYR/PP interface [polypeptide binding]; other site
281310002655	dimer interface [polypeptide binding]; other site
281310002656	TPP binding site [chemical binding]; other site
281310002657	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
281310002658	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
281310002659	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
281310002660	threonine dehydratase; Reviewed; Region: PRK09224
281310002661	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
281310002662	tetramer interface [polypeptide binding]; other site
281310002663	pyridoxal 5'-phosphate binding site [chemical binding]; other site
281310002664	catalytic residue [active]
281310002665	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
281310002666	putative Ile/Val binding site [chemical binding]; other site
281310002667	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
281310002668	putative Ile/Val binding site [chemical binding]; other site
281310002669	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
281310002670	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
281310002671	putative active site [active]
281310002672	putative PHP Thumb interface [polypeptide binding]; other site
281310002673	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
281310002674	generic binding surface II; other site
281310002675	generic binding surface I; other site
281310002676	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
281310002677	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
281310002678	active site
281310002679	substrate binding site [chemical binding]; other site
281310002680	metal binding site [ion binding]; metal-binding site
281310002681	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
281310002682	SecA binding site; other site
281310002683	Preprotein binding site; other site
281310002684	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
281310002685	active site residue [active]
281310002686	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
281310002687	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
281310002688	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
281310002689	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
281310002690	Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937
281310002691	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
281310002692	putative acyl-acceptor binding pocket; other site
281310002693	LexA repressor; Validated; Region: PRK00215
281310002694	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
281310002695	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
281310002696	Catalytic site [active]
281310002697	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
281310002698	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
281310002699	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
281310002700	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
281310002701	dimer interface [polypeptide binding]; other site
281310002702	catalytic triad [active]
281310002703	peroxidatic and resolving cysteines [active]
281310002704	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
281310002705	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
281310002706	dimerization interface [polypeptide binding]; other site
281310002707	ATP binding site [chemical binding]; other site
281310002708	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
281310002709	dimerization interface [polypeptide binding]; other site
281310002710	ATP binding site [chemical binding]; other site
281310002711	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
281310002712	putative active site [active]
281310002713	catalytic triad [active]
281310002714	NTHIp0910B; similar to: Lex2A homolog, C-terminal fragment
281310002715	NTHIp0910A; similar to: Lex2A homolog, N-terminal fragment
281310002716	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
281310002717	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
281310002718	NodB motif; other site
281310002719	putative active site [active]
281310002720	putative catalytic site [active]
281310002721	Zn binding site [ion binding]; other site
281310002722	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
281310002723	Peptidase family M23; Region: Peptidase_M23; pfam01551
281310002724	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
281310002725	catalytic core [active]
281310002726	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
281310002727	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
281310002728	adenine DNA glycosylase; Provisional; Region: PRK10880
281310002729	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
281310002730	minor groove reading motif; other site
281310002731	helix-hairpin-helix signature motif; other site
281310002732	substrate binding pocket [chemical binding]; other site
281310002733	active site
281310002734	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
281310002735	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
281310002736	DNA binding and oxoG recognition site [nucleotide binding]
281310002737	oxidative damage protection protein; Provisional; Region: PRK05408
281310002738	murein transglycosylase C; Provisional; Region: mltC; PRK11671
281310002739	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
281310002740	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
281310002741	N-acetyl-D-glucosamine binding site [chemical binding]; other site
281310002742	catalytic residue [active]
281310002743	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
281310002744	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
281310002745	active site
281310002746	metal binding site [ion binding]; metal-binding site
281310002747	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
281310002748	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
281310002749	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
281310002750	active site
281310002751	(T/H)XGH motif; other site
281310002752	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
281310002753	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK01792
281310002754	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
281310002755	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
281310002756	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
281310002757	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
281310002758	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
281310002759	S-adenosylmethionine binding site [chemical binding]; other site
281310002760	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
281310002761	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
281310002762	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
281310002763	P loop; other site
281310002764	GTP binding site [chemical binding]; other site
281310002765	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
281310002766	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
281310002767	Walker A/P-loop; other site
281310002768	ATP binding site [chemical binding]; other site
281310002769	Q-loop/lid; other site
281310002770	ABC transporter signature motif; other site
281310002771	Walker B; other site
281310002772	D-loop; other site
281310002773	H-loop/switch region; other site
281310002774	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
281310002775	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
281310002776	putative acyltransferase; Provisional; Region: PRK05790
281310002777	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
281310002778	dimer interface [polypeptide binding]; other site
281310002779	active site
281310002780	Short chain fatty acid transporter; Region: SCFA_trans; pfam02667
281310002781	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
281310002782	acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920
281310002783	Transcriptional regulator [Transcription]; Region: LysR; COG0583
281310002784	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
281310002785	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
281310002786	dimerization interface [polypeptide binding]; other site
281310002787	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
281310002788	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
281310002789	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
281310002790	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
281310002791	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
281310002792	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
281310002793	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
281310002794	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
281310002795	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
281310002796	protein-rRNA interface [nucleotide binding]; other site
281310002797	putative translocon binding site; other site
281310002798	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
281310002799	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
281310002800	G-X-X-G motif; other site
281310002801	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
281310002802	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
281310002803	23S rRNA interface [nucleotide binding]; other site
281310002804	5S rRNA interface [nucleotide binding]; other site
281310002805	putative antibiotic binding site [chemical binding]; other site
281310002806	L25 interface [polypeptide binding]; other site
281310002807	L27 interface [polypeptide binding]; other site
281310002808	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
281310002809	23S rRNA interface [nucleotide binding]; other site
281310002810	putative translocon interaction site; other site
281310002811	signal recognition particle (SRP54) interaction site; other site
281310002812	L23 interface [polypeptide binding]; other site
281310002813	trigger factor interaction site; other site
281310002814	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
281310002815	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
281310002816	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
281310002817	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
281310002818	RNA binding site [nucleotide binding]; other site
281310002819	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
281310002820	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
281310002821	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
281310002822	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
281310002823	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
281310002824	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
281310002825	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
281310002826	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
281310002827	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
281310002828	5S rRNA interface [nucleotide binding]; other site
281310002829	L27 interface [polypeptide binding]; other site
281310002830	23S rRNA interface [nucleotide binding]; other site
281310002831	L5 interface [polypeptide binding]; other site
281310002832	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
281310002833	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
281310002834	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
281310002835	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
281310002836	23S rRNA binding site [nucleotide binding]; other site
281310002837	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
281310002838	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
281310002839	SecY translocase; Region: SecY; pfam00344
281310002840	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
281310002841	30S ribosomal protein S13; Region: bact_S13; TIGR03631
281310002842	30S ribosomal protein S11; Validated; Region: PRK05309
281310002843	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
281310002844	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
281310002845	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
281310002846	RNA binding surface [nucleotide binding]; other site
281310002847	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
281310002848	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
281310002849	alphaNTD homodimer interface [polypeptide binding]; other site
281310002850	alphaNTD - beta interaction site [polypeptide binding]; other site
281310002851	alphaNTD - beta' interaction site [polypeptide binding]; other site
281310002852	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
281310002853	Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203
281310002854	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
281310002855	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
281310002856	ligand binding site [chemical binding]; other site
281310002857	flexible hinge region; other site
281310002858	putative switch regulator; other site
281310002859	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
281310002860	non-specific DNA interactions [nucleotide binding]; other site
281310002861	DNA binding site [nucleotide binding]
281310002862	sequence specific DNA binding site [nucleotide binding]; other site
281310002863	putative cAMP binding site [chemical binding]; other site
281310002864	product: pseudogene for conserved hypothetical protein, predicted arylsulfatase regulator, Fe-S oxidoreductase, authentic frameshift; This region contains an authentic frameshift or in-frame stop in the coding sequence and is not the result of a sequencing error.
281310002865	NTHIp0968B; similar to: hypothetical protein, predicted arylsulfatase regulator, Fe-S oxidoreductase, C-terminal fragment
281310002866	NTHIp0968A; similar to: hypothetical protein, predicted arylsulfatase regulator, Fe-S oxidoreductase, N-terminal fragment
281310002867	Predicted permeases [General function prediction only]; Region: COG0730
281310002868	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
281310002869	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
281310002870	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
281310002871	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
281310002872	ribosome recycling factor; Reviewed; Region: frr; PRK00083
281310002873	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
281310002874	hinge region; other site
281310002875	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
281310002876	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
281310002877	active site
281310002878	substrate-binding site [chemical binding]; other site
281310002879	metal-binding site [ion binding]
281310002880	ATP binding site [chemical binding]; other site
281310002881	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
281310002882	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
281310002883	dimerization interface [polypeptide binding]; other site
281310002884	domain crossover interface; other site
281310002885	redox-dependent activation switch; other site
281310002886	argininosuccinate lyase; Provisional; Region: PRK04833
281310002887	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
281310002888	active sites [active]
281310002889	tetramer interface [polypeptide binding]; other site
281310002890	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
281310002891	active site
281310002892	tetramer interface; other site
281310002893	carbon storage regulator; Provisional; Region: PRK01712
281310002894	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
281310002895	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
281310002896	motif 1; other site
281310002897	active site
281310002898	motif 2; other site
281310002899	motif 3; other site
281310002900	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
281310002901	DHHA1 domain; Region: DHHA1; pfam02272
281310002902	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
281310002903	Ligand Binding Site [chemical binding]; other site
281310002904	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
281310002905	proline aminopeptidase P II; Provisional; Region: PRK10879
281310002906	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
281310002907	active site
281310002908	hypothetical protein; Reviewed; Region: PRK01736
281310002909	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
281310002910	active site
281310002911	catalytic residues [active]
281310002912	galactokinase; Provisional; Region: PRK05101
281310002913	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
281310002914	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
281310002915	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
281310002916	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
281310002917	dimer interface [polypeptide binding]; other site
281310002918	active site
281310002919	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
281310002920	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
281310002921	DNA binding site [nucleotide binding]
281310002922	domain linker motif; other site
281310002923	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
281310002924	ligand binding site [chemical binding]; other site
281310002925	dimerization interface (closed form) [polypeptide binding]; other site
281310002926	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
281310002927	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
281310002928	ligand binding site [chemical binding]; other site
281310002929	calcium binding site [ion binding]; other site
281310002930	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
281310002931	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
281310002932	Walker A/P-loop; other site
281310002933	ATP binding site [chemical binding]; other site
281310002934	Q-loop/lid; other site
281310002935	ABC transporter signature motif; other site
281310002936	Walker B; other site
281310002937	D-loop; other site
281310002938	H-loop/switch region; other site
281310002939	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
281310002940	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
281310002941	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
281310002942	TM-ABC transporter signature motif; other site
281310002943	Intracellular septation protein A [Cell division and chromosome partitioning]; Region: COG2917
281310002944	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
281310002945	YciI-like protein; Reviewed; Region: PRK11370
281310002946	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
281310002947	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
281310002948	N-acetyl-D-glucosamine binding site [chemical binding]; other site
281310002949	catalytic residue [active]
281310002950	Trp operon repressor; Provisional; Region: PRK01381
281310002951	monofunctional biosynthetic peptidoglycan transglycosylase; Region: mono_pep_trsgly; TIGR02070
281310002952	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
281310002953	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
281310002954	Iron-sulfur protein interface; other site
281310002955	proximal quinone binding site [chemical binding]; other site
281310002956	C-subunit interface; other site
281310002957	distal quinone binding site; other site
281310002958	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
281310002959	D-subunit interface [polypeptide binding]; other site
281310002960	Iron-sulfur protein interface; other site
281310002961	proximal quinone binding site [chemical binding]; other site
281310002962	distal quinone binding site [chemical binding]; other site
281310002963	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
281310002964	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
281310002965	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
281310002966	L-aspartate oxidase; Provisional; Region: PRK06175
281310002967	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
281310002968	poxB regulator PoxA; Provisional; Region: PRK09350
281310002969	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
281310002970	motif 1; other site
281310002971	dimer interface [polypeptide binding]; other site
281310002972	active site
281310002973	motif 2; other site
281310002974	motif 3; other site
281310002975	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
281310002976	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
281310002977	active site
281310002978	phosphorylation site [posttranslational modification]
281310002979	intermolecular recognition site; other site
281310002980	dimerization interface [polypeptide binding]; other site
281310002981	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
281310002982	DNA binding site [nucleotide binding]
281310002983	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
281310002984	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
281310002985	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
281310002986	Nucleoid-associated protein [General function prediction only]; Region: COG3081
281310002987	nucleoid-associated protein NdpA; Validated; Region: PRK00378
281310002988	hypothetical protein; Provisional; Region: PRK13689
281310002989	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
281310002990	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
281310002991	Sulfatase; Region: Sulfatase; cl17466
281310002992	hypothetical protein; Validated; Region: PRK06886
281310002993	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
281310002994	active site
281310002995	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
281310002996	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
281310002997	GTP binding site; other site
281310002998	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3084
281310002999	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
281310003000	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
281310003001	catalytic residues [active]
281310003002	hinge region; other site
281310003003	alpha helical domain; other site
281310003004	hypothetical protein; Provisional; Region: PRK11027
281310003005	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
281310003006	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
281310003007	S-adenosylmethionine binding site [chemical binding]; other site
281310003008	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
281310003009	Positive regulator of sigma E activity [Signal transduction mechanisms]; Region: RseC; COG3086
281310003010	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
281310003011	Walker A motif; other site
281310003012	putative transporter; Provisional; Region: PRK10504
281310003013	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
281310003014	putative substrate translocation pore; other site
281310003015	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
281310003016	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
281310003017	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
281310003018	peptide binding site [polypeptide binding]; other site
281310003019	heme oxygenase, HugZ family; Region: heme_ox_HugZ; TIGR04109
281310003020	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
281310003021	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
281310003022	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
281310003023	DNA polymerase I; Provisional; Region: PRK05755
281310003024	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
281310003025	active site
281310003026	metal binding site 1 [ion binding]; metal-binding site
281310003027	putative 5' ssDNA interaction site; other site
281310003028	metal binding site 3; metal-binding site
281310003029	metal binding site 2 [ion binding]; metal-binding site
281310003030	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
281310003031	putative DNA binding site [nucleotide binding]; other site
281310003032	putative metal binding site [ion binding]; other site
281310003033	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
281310003034	active site
281310003035	catalytic site [active]
281310003036	substrate binding site [chemical binding]; other site
281310003037	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
281310003038	active site
281310003039	DNA binding site [nucleotide binding]
281310003040	catalytic site [active]
281310003041	Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division,    chromosome partitioning]; Region: zapA; COG3027
281310003042	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
281310003043	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
281310003044	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
281310003045	Clp amino terminal domain; Region: Clp_N; pfam02861
281310003046	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
281310003047	Walker A motif; other site
281310003048	ATP binding site [chemical binding]; other site
281310003049	Walker B motif; other site
281310003050	arginine finger; other site
281310003051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
281310003052	Walker A motif; other site
281310003053	ATP binding site [chemical binding]; other site
281310003054	Walker B motif; other site
281310003055	arginine finger; other site
281310003056	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
281310003057	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
281310003058	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
281310003059	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
281310003060	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
281310003061	VacB and RNase II family 3'-5' exoribonucleases; Region: 3_prime_RNase; TIGR00358
281310003062	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
281310003063	RNB domain; Region: RNB; pfam00773
281310003064	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
281310003065	RNA binding site [nucleotide binding]; other site
281310003066	hypothetical protein; Provisional; Region: PRK11212
281310003067	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
281310003068	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
281310003069	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
281310003070	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
281310003071	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
281310003072	G1 box; other site
281310003073	putative GEF interaction site [polypeptide binding]; other site
281310003074	GTP/Mg2+ binding site [chemical binding]; other site
281310003075	Switch I region; other site
281310003076	G2 box; other site
281310003077	G3 box; other site
281310003078	Switch II region; other site
281310003079	G4 box; other site
281310003080	G5 box; other site
281310003081	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
281310003082	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
281310003083	Alpha-2,3-sialyltransferase (CST-I); Region: CST-I; pfam06002
281310003084	glutamine synthetase; Provisional; Region: glnA; PRK09469
281310003085	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
281310003086	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
281310003087	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
281310003088	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
281310003089	NAD binding site [chemical binding]; other site
281310003090	substrate binding site [chemical binding]; other site
281310003091	homodimer interface [polypeptide binding]; other site
281310003092	active site
281310003093	aminopeptidase B; Provisional; Region: PRK05015
281310003094	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
281310003095	interface (dimer of trimers) [polypeptide binding]; other site
281310003096	Substrate-binding/catalytic site; other site
281310003097	Zn-binding sites [ion binding]; other site
281310003098	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
281310003099	active site
281310003100	multimer interface [polypeptide binding]; other site
281310003101	GTPase CgtA; Reviewed; Region: obgE; PRK12298
281310003102	GTP1/OBG; Region: GTP1_OBG; pfam01018
281310003103	Obg GTPase; Region: Obg; cd01898
281310003104	G1 box; other site
281310003105	GTP/Mg2+ binding site [chemical binding]; other site
281310003106	Switch I region; other site
281310003107	G2 box; other site
281310003108	G3 box; other site
281310003109	Switch II region; other site
281310003110	G4 box; other site
281310003111	G5 box; other site
281310003112	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
281310003113	EamA-like transporter family; Region: EamA; pfam00892
281310003114	EamA-like transporter family; Region: EamA; pfam00892
281310003115	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
281310003116	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
281310003117	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
281310003118	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
281310003119	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
281310003120	substrate binding pocket [chemical binding]; other site
281310003121	chain length determination region; other site
281310003122	substrate-Mg2+ binding site; other site
281310003123	catalytic residues [active]
281310003124	aspartate-rich region 1; other site
281310003125	active site lid residues [active]
281310003126	aspartate-rich region 2; other site
281310003127	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
281310003128	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
281310003129	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
281310003130	two-component response regulator; Provisional; Region: PRK11173
281310003131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
281310003132	active site
281310003133	phosphorylation site [posttranslational modification]
281310003134	intermolecular recognition site; other site
281310003135	dimerization interface [polypeptide binding]; other site
281310003136	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
281310003137	DNA binding site [nucleotide binding]
281310003138	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
281310003139	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
281310003140	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
281310003141	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
281310003142	DsbD alpha interface [polypeptide binding]; other site
281310003143	catalytic residues [active]
281310003144	Predicted membrane protein [Function unknown]; Region: COG2259
281310003145	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
281310003146	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
281310003147	purine monophosphate binding site [chemical binding]; other site
281310003148	dimer interface [polypeptide binding]; other site
281310003149	putative catalytic residues [active]
281310003150	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
281310003151	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
281310003152	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
281310003153	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
281310003154	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
281310003155	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
281310003156	NTHIp1053A; similar to: predicted membrane-associated, metal-dependent hydrolase, N-terminal fragment
281310003157	NTHIp1053B; similar to: predicted membrane-associated, metal-dependent hydrolase, C-terminal fragment
281310003158	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
281310003159	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
281310003160	dimer interface [polypeptide binding]; other site
281310003161	active site
281310003162	glycine-pyridoxal phosphate binding site [chemical binding]; other site
281310003163	folate binding site [chemical binding]; other site
281310003164	dephospho-CoA kinase; Region: TIGR00152
281310003165	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
281310003166	CoA-binding site [chemical binding]; other site
281310003167	ATP-binding [chemical binding]; other site
281310003168	DNA gyrase inhibitor; Reviewed; Region: PRK00418
281310003169	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
281310003170	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
281310003171	ATP binding site [chemical binding]; other site
281310003172	Mg++ binding site [ion binding]; other site
281310003173	motif III; other site
281310003174	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
281310003175	nucleotide binding region [chemical binding]; other site
281310003176	ATP-binding site [chemical binding]; other site
281310003177	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
281310003178	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
281310003179	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
281310003180	HlyD family secretion protein; Region: HlyD_3; pfam13437
281310003181	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
281310003182	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
281310003183	Sporulation related domain; Region: SPOR; pfam05036
281310003184	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
281310003185	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
281310003186	putative substrate translocation pore; other site
281310003187	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
281310003188	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
281310003189	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
281310003190	HlyD family secretion protein; Region: HlyD_3; pfam13437
281310003191	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
281310003192	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
281310003193	folate binding site [chemical binding]; other site
281310003194	NADP+ binding site [chemical binding]; other site
281310003195	gamma-glutamyl kinase; Provisional; Region: PRK05429
281310003196	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
281310003197	nucleotide binding site [chemical binding]; other site
281310003198	homotetrameric interface [polypeptide binding]; other site
281310003199	putative phosphate binding site [ion binding]; other site
281310003200	putative allosteric binding site; other site
281310003201	PUA domain; Region: PUA; pfam01472
281310003202	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
281310003203	putative active site [active]
281310003204	Ap4A binding site [chemical binding]; other site
281310003205	nudix motif; other site
281310003206	putative metal binding site [ion binding]; other site
281310003207	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
281310003208	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
281310003209	thymidylate synthase; Reviewed; Region: thyA; PRK01827
281310003210	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
281310003211	dimerization interface [polypeptide binding]; other site
281310003212	active site
281310003213	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
281310003214	nucleoside/Zn binding site; other site
281310003215	dimer interface [polypeptide binding]; other site
281310003216	catalytic motif [active]
281310003217	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701
281310003218	Protein of unknown function (DUF2547); Region: DUF2547; pfam10818
281310003219	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
281310003220	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
281310003221	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
281310003222	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
281310003223	nucleotide binding region [chemical binding]; other site
281310003224	ATP-binding site [chemical binding]; other site
281310003225	SEC-C motif; Region: SEC-C; pfam02810
281310003226	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
281310003227	active site
281310003228	8-oxo-dGMP binding site [chemical binding]; other site
281310003229	nudix motif; other site
281310003230	metal binding site [ion binding]; metal-binding site
281310003231	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
281310003232	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
281310003233	TrkA-N domain; Region: TrkA_N; pfam02254
281310003234	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
281310003235	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
281310003236	rRNA interaction site [nucleotide binding]; other site
281310003237	S8 interaction site; other site
281310003238	putative laminin-1 binding site; other site
281310003239	elongation factor Ts; Provisional; Region: tsf; PRK09377
281310003240	UBA/TS-N domain; Region: UBA; pfam00627
281310003241	Elongation factor TS; Region: EF_TS; pfam00889
281310003242	Elongation factor TS; Region: EF_TS; pfam00889
281310003243	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
281310003244	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
281310003245	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
281310003246	trimer interface [polypeptide binding]; other site
281310003247	active site
281310003248	UDP-GlcNAc binding site [chemical binding]; other site
281310003249	lipid binding site [chemical binding]; lipid-binding site
281310003250	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825
281310003251	periplasmic chaperone; Provisional; Region: PRK10780
281310003252	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
281310003253	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
281310003254	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
281310003255	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
281310003256	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
281310003257	Surface antigen; Region: Bac_surface_Ag; pfam01103
281310003258	zinc metallopeptidase RseP; Provisional; Region: PRK10779
281310003259	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
281310003260	active site
281310003261	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
281310003262	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
281310003263	protein binding site [polypeptide binding]; other site
281310003264	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
281310003265	putative substrate binding region [chemical binding]; other site
281310003266	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
281310003267	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
281310003268	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
281310003269	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
281310003270	catalytic residue [active]
281310003271	putative FPP diphosphate  binding site; other site
281310003272	putative FPP binding hydrophobic cleft; other site
281310003273	dimer interface [polypeptide binding]; other site
281310003274	putative IPP diphosphate binding site; other site
281310003275	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
281310003276	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
281310003277	HIGH motif; other site
281310003278	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
281310003279	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
281310003280	active site
281310003281	KMSKS motif; other site
281310003282	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
281310003283	tRNA binding surface [nucleotide binding]; other site
281310003284	Rare lipoprotein B [Cell envelope biogenesis, outer membrane]; Region: RlpB; COG2980
281310003285	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
281310003286	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
281310003287	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
281310003288	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
281310003289	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
281310003290	putative active site [active]
281310003291	Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545
281310003292	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
281310003293	dimer interface [polypeptide binding]; other site
281310003294	motif 1; other site
281310003295	active site
281310003296	motif 2; other site
281310003297	motif 3; other site
281310003298	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
281310003299	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
281310003300	tetramer interface [polypeptide binding]; other site
281310003301	heme binding pocket [chemical binding]; other site
281310003302	NADPH binding site [chemical binding]; other site
281310003303	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
281310003304	Protein of unknown function (DUF1190); Region: DUF1190; cl10031
281310003305	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4316
281310003306	enolase; Provisional; Region: eno; PRK00077
281310003307	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
281310003308	dimer interface [polypeptide binding]; other site
281310003309	metal binding site [ion binding]; metal-binding site
281310003310	substrate binding pocket [chemical binding]; other site
281310003311	Predicted flavoproteins [General function prediction only]; Region: COG2081
281310003312	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
281310003313	cytochrome c nitrite reductase, accessory protein NrfF; Region: cyt_nit_nrfF; TIGR03147
281310003314	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
281310003315	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
281310003316	binding surface
281310003317	TPR motif; other site
281310003318	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
281310003319	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
281310003320	catalytic residues [active]
281310003321	central insert; other site
281310003322	cytochrome c nitrate reductase biogenesis protein NrfE; Region: cyt_nit_nrfE; TIGR03145
281310003323	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
281310003324	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
281310003325	active site
281310003326	dimerization interface [polypeptide binding]; other site
281310003327	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
281310003328	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
281310003329	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
281310003330	Protein of unknown function (DUF2572); Region: DUF2572; pfam10833
281310003331	Rod binding protein; Region: Rod-binding; cl01626
281310003332	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
281310003333	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
281310003334	transcriptional regulator NrdR; Region: TIGR00244
281310003335	ATP cone domain; Region: ATP-cone; pfam03477
281310003336	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
281310003337	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
281310003338	catalytic motif [active]
281310003339	Zn binding site [ion binding]; other site
281310003340	riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227
281310003341	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
281310003342	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
281310003343	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
281310003344	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
281310003345	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
281310003346	DNA binding site [nucleotide binding]
281310003347	catalytic residue [active]
281310003348	H2TH interface [polypeptide binding]; other site
281310003349	putative catalytic residues [active]
281310003350	turnover-facilitating residue; other site
281310003351	intercalation triad [nucleotide binding]; other site
281310003352	8OG recognition residue [nucleotide binding]; other site
281310003353	putative reading head residues; other site
281310003354	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
281310003355	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
281310003356	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
281310003357	pyridoxal 5'-phosphate binding site [chemical binding]; other site
281310003358	catalytic residue [active]
281310003359	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
281310003360	oligomeric interface; other site
281310003361	putative active site [active]
281310003362	homodimer interface [polypeptide binding]; other site
281310003363	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
281310003364	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931
281310003365	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
281310003366	inhibitor-cofactor binding pocket; inhibition site
281310003367	pyridoxal 5'-phosphate binding site [chemical binding]; other site
281310003368	catalytic residue [active]
281310003369	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
281310003370	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
281310003371	hypothetical protein; Reviewed; Region: PRK00024
281310003372	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
281310003373	MPN+ (JAMM) motif; other site
281310003374	Zinc-binding site [ion binding]; other site
281310003375	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
281310003376	Flavoprotein; Region: Flavoprotein; pfam02441
281310003377	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
281310003378	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
281310003379	trimer interface [polypeptide binding]; other site
281310003380	active site
281310003381	division inhibitor protein; Provisional; Region: slmA; PRK09480
281310003382	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
281310003383	hypothetical protein; Provisional; Region: PRK04966
281310003384	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
281310003385	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
281310003386	ligand binding site [chemical binding]; other site
281310003387	flexible hinge region; other site
281310003388	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
281310003389	putative switch regulator; other site
281310003390	non-specific DNA interactions [nucleotide binding]; other site
281310003391	DNA binding site [nucleotide binding]
281310003392	sequence specific DNA binding site [nucleotide binding]; other site
281310003393	putative cAMP binding site [chemical binding]; other site
281310003394	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
281310003395	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
281310003396	beta-hexosaminidase; Provisional; Region: PRK05337
281310003397	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
281310003398	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
281310003399	putative dimer interface [polypeptide binding]; other site
281310003400	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
281310003401	nucleotide binding site/active site [active]
281310003402	HIT family signature motif; other site
281310003403	catalytic residue [active]
281310003404	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
281310003405	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
281310003406	active site
281310003407	HIGH motif; other site
281310003408	nucleotide binding site [chemical binding]; other site
281310003409	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
281310003410	active site
281310003411	KMSKS motif; other site
281310003412	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
281310003413	tRNA binding surface [nucleotide binding]; other site
281310003414	anticodon binding site; other site
281310003415	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
281310003416	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
281310003417	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
281310003418	active site
281310003419	Riboflavin kinase; Region: Flavokinase; smart00904
281310003420	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
281310003421	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
281310003422	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
281310003423	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
281310003424	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
281310003425	substrate binding site [chemical binding]; other site
281310003426	oxyanion hole (OAH) forming residues; other site
281310003427	trimer interface [polypeptide binding]; other site
281310003428	O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441
281310003429	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
281310003430	active site
281310003431	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
281310003432	Dehydroquinase class II; Region: DHquinase_II; pfam01220
281310003433	active site
281310003434	trimer interface [polypeptide binding]; other site
281310003435	dimer interface [polypeptide binding]; other site
281310003436	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
281310003437	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
281310003438	carboxyltransferase (CT) interaction site; other site
281310003439	biotinylation site [posttranslational modification]; other site
281310003440	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
281310003441	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
281310003442	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
281310003443	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
281310003444	Predicted membrane protein [Function unknown]; Region: COG3924
281310003445	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
281310003446	Na binding site [ion binding]; other site
281310003447	EamA-like transporter family; Region: EamA; pfam00892
281310003448	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
281310003449	EamA-like transporter family; Region: EamA; pfam00892
281310003450	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
281310003451	Methyltransferase domain; Region: Methyltransf_18; pfam12847
281310003452	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
281310003453	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
281310003454	FMN binding site [chemical binding]; other site
281310003455	active site
281310003456	catalytic residues [active]
281310003457	substrate binding site [chemical binding]; other site
281310003458	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
281310003459	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
281310003460	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
281310003461	SmpB-tmRNA interface; other site
281310003462	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
281310003463	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
281310003464	active site
281310003465	ADP/pyrophosphate binding site [chemical binding]; other site
281310003466	dimerization interface [polypeptide binding]; other site
281310003467	allosteric effector site; other site
281310003468	fructose-1,6-bisphosphate binding site; other site
281310003469	hypothetical protein; Validated; Region: PRK02101
281310003470	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
281310003471	DNA protecting protein DprA; Region: dprA; TIGR00732
281310003472	2-isopropylmalate synthase; Validated; Region: PRK00915
281310003473	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
281310003474	active site
281310003475	catalytic residues [active]
281310003476	metal binding site [ion binding]; metal-binding site
281310003477	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
281310003478	tartrate dehydrogenase; Region: TTC; TIGR02089
281310003479	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
281310003480	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
281310003481	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
281310003482	substrate binding site [chemical binding]; other site
281310003483	ligand binding site [chemical binding]; other site
281310003484	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
281310003485	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
281310003486	substrate binding site [chemical binding]; other site
281310003487	Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395
281310003488	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
281310003489	Autotransporter beta-domain; Region: Autotransporter; pfam03797
281310003490	recF protein; Region: recf; TIGR00611
281310003491	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
281310003492	Walker A/P-loop; other site
281310003493	ATP binding site [chemical binding]; other site
281310003494	Q-loop/lid; other site
281310003495	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
281310003496	ABC transporter signature motif; other site
281310003497	Walker B; other site
281310003498	D-loop; other site
281310003499	H-loop/switch region; other site
281310003500	DNA polymerase III subunit beta; Validated; Region: PRK05643
281310003501	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
281310003502	putative DNA binding surface [nucleotide binding]; other site
281310003503	dimer interface [polypeptide binding]; other site
281310003504	beta-clamp/clamp loader binding surface; other site
281310003505	beta-clamp/translesion DNA polymerase binding surface; other site
281310003506	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
281310003507	DnaA N-terminal domain; Region: DnaA_N; pfam11638
281310003508	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
281310003509	Walker A motif; other site
281310003510	ATP binding site [chemical binding]; other site
281310003511	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
281310003512	Walker B motif; other site
281310003513	arginine finger; other site
281310003514	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
281310003515	DnaA box-binding interface [nucleotide binding]; other site
281310003516	TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776
281310003517	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
281310003518	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
281310003519	Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298
281310003520	Protein of unknown function (DUF560); Region: DUF560; pfam04575
281310003521	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
281310003522	ribonuclease P; Reviewed; Region: rnpA; PRK01732
281310003523	hypothetical protein; Validated; Region: PRK00041
281310003524	membrane protein insertase; Provisional; Region: PRK01318
281310003525	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
281310003526	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
281310003527	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
281310003528	trmE is a tRNA modification GTPase; Region: trmE; cd04164
281310003529	G1 box; other site
281310003530	GTP/Mg2+ binding site [chemical binding]; other site
281310003531	Switch I region; other site
281310003532	G2 box; other site
281310003533	Switch II region; other site
281310003534	G3 box; other site
281310003535	G4 box; other site
281310003536	G5 box; other site
281310003537	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
281310003538	periplasmic folding chaperone; Provisional; Region: PRK10788
281310003539	SurA N-terminal domain; Region: SurA_N_3; cl07813
281310003540	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
281310003541	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
281310003542	Sulfatase; Region: Sulfatase; pfam00884
281310003543	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
281310003544	lipoprotein signal peptidase; Provisional; Region: PRK14787
281310003545	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
281310003546	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
281310003547	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
281310003548	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
281310003549	thiamine ABC transporter, periplasmic binding protein; Region: thiB; TIGR01276
281310003550	thiamine ABC transporter, permease protein; Region: thiP; TIGR01253
281310003551	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310003552	dimer interface [polypeptide binding]; other site
281310003553	conserved gate region; other site
281310003554	putative PBP binding loops; other site
281310003555	ABC-ATPase subunit interface; other site
281310003556	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310003557	dimer interface [polypeptide binding]; other site
281310003558	conserved gate region; other site
281310003559	putative PBP binding loops; other site
281310003560	ABC-ATPase subunit interface; other site
281310003561	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
281310003562	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
281310003563	Walker A/P-loop; other site
281310003564	ATP binding site [chemical binding]; other site
281310003565	Q-loop/lid; other site
281310003566	ABC transporter signature motif; other site
281310003567	Walker B; other site
281310003568	D-loop; other site
281310003569	H-loop/switch region; other site
281310003570	biotin synthase; Region: bioB; TIGR00433
281310003571	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
281310003572	FeS/SAM binding site; other site
281310003573	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
281310003574	transketolase; Reviewed; Region: PRK12753
281310003575	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
281310003576	TPP-binding site [chemical binding]; other site
281310003577	dimer interface [polypeptide binding]; other site
281310003578	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
281310003579	PYR/PP interface [polypeptide binding]; other site
281310003580	dimer interface [polypeptide binding]; other site
281310003581	TPP binding site [chemical binding]; other site
281310003582	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
281310003583	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
281310003584	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
281310003585	motif II; other site
281310003586	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
281310003587	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
281310003588	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
281310003589	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
281310003590	Cl binding site [ion binding]; other site
281310003591	oligomer interface [polypeptide binding]; other site
281310003592	YGGT family; Region: YGGT; pfam02325
281310003593	YGGT family; Region: YGGT; pfam02325
281310003594	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
281310003595	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
281310003596	putative active site [active]
281310003597	putative dimer interface [polypeptide binding]; other site
281310003598	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
281310003599	AAA domain; Region: AAA_14; pfam13173
281310003600	ferredoxin-type protein NapF; Region: napF; TIGR00402
281310003601	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
281310003602	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
281310003603	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
281310003604	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
281310003605	4Fe-4S binding domain; Region: Fer4; cl02805
281310003606	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
281310003607	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
281310003608	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
281310003609	putative [Fe4-S4] binding site [ion binding]; other site
281310003610	putative molybdopterin cofactor binding site [chemical binding]; other site
281310003611	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
281310003612	putative molybdopterin cofactor binding site; other site
281310003613	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
281310003614	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
281310003615	MerT mercuric transport protein; Region: MerT; cl03578
281310003616	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
281310003617	metal-binding site [ion binding]
281310003618	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
281310003619	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
281310003620	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
281310003621	Walker A/P-loop; other site
281310003622	ATP binding site [chemical binding]; other site
281310003623	Q-loop/lid; other site
281310003624	ABC transporter signature motif; other site
281310003625	Walker B; other site
281310003626	D-loop; other site
281310003627	H-loop/switch region; other site
281310003628	Cupin; Region: Cupin_6; pfam12852
281310003629	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
281310003630	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
281310003631	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
281310003632	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
281310003633	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421
281310003634	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421
281310003635	NTHIp1217B; similar to:  type III restriction-modification system HindVIP enzyme mod, C-terminal fragment
281310003636	NTHIp1217A; similar to:  type III restriction-modification system HindVIP enzyme mod, N-terminal fragment
281310003637	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
281310003638	RNA/DNA hybrid binding site [nucleotide binding]; other site
281310003639	active site
281310003640	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
281310003641	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
281310003642	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
281310003643	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
281310003644	active site
281310003645	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
281310003646	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
281310003647	Sulfatase; Region: Sulfatase; pfam00884
281310003648	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
281310003649	putative nucleotide binding site [chemical binding]; other site
281310003650	uridine monophosphate binding site [chemical binding]; other site
281310003651	homohexameric interface [polypeptide binding]; other site
281310003652	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
281310003653	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
281310003654	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
281310003655	cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146
281310003656	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
281310003657	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
281310003658	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
281310003659	ATP binding site [chemical binding]; other site
281310003660	putative Mg++ binding site [ion binding]; other site
281310003661	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
281310003662	nucleotide binding region [chemical binding]; other site
281310003663	ATP-binding site [chemical binding]; other site
281310003664	Helicase associated domain (HA2); Region: HA2; pfam04408
281310003665	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
281310003666	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
281310003667	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
281310003668	Predicted membrane protein [Function unknown]; Region: COG2707
281310003669	cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203
281310003670	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
281310003671	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
281310003672	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
281310003673	CTP synthetase; Validated; Region: pyrG; PRK05380
281310003674	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
281310003675	Catalytic site [active]
281310003676	active site
281310003677	UTP binding site [chemical binding]; other site
281310003678	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
281310003679	active site
281310003680	putative oxyanion hole; other site
281310003681	catalytic triad [active]
281310003682	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
281310003683	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
281310003684	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
281310003685	Walker A/P-loop; other site
281310003686	ATP binding site [chemical binding]; other site
281310003687	Q-loop/lid; other site
281310003688	ABC transporter signature motif; other site
281310003689	Walker B; other site
281310003690	D-loop; other site
281310003691	H-loop/switch region; other site
281310003692	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
281310003693	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310003694	dimer interface [polypeptide binding]; other site
281310003695	conserved gate region; other site
281310003696	putative PBP binding loops; other site
281310003697	ABC-ATPase subunit interface; other site
281310003698	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
281310003699	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
281310003700	substrate binding pocket [chemical binding]; other site
281310003701	membrane-bound complex binding site; other site
281310003702	hinge residues; other site
281310003703	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
281310003704	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
281310003705	hinge; other site
281310003706	active site
281310003707	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
281310003708	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
281310003709	anti sigma factor interaction site; other site
281310003710	regulatory phosphorylation site [posttranslational modification]; other site
281310003711	ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; COG2854
281310003712	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
281310003713	mce related protein; Region: MCE; pfam02470
281310003714	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
281310003715	conserved hypothetical integral membrane protein; Region: TIGR00056
281310003716	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
281310003717	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
281310003718	Walker A/P-loop; other site
281310003719	ATP binding site [chemical binding]; other site
281310003720	Q-loop/lid; other site
281310003721	ABC transporter signature motif; other site
281310003722	Walker B; other site
281310003723	D-loop; other site
281310003724	H-loop/switch region; other site
281310003725	superoxide dismutase; Provisional; Region: PRK10925
281310003726	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
281310003727	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
281310003728	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
281310003729	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
281310003730	Walker A/P-loop; other site
281310003731	ATP binding site [chemical binding]; other site
281310003732	Q-loop/lid; other site
281310003733	ABC transporter signature motif; other site
281310003734	Walker B; other site
281310003735	D-loop; other site
281310003736	H-loop/switch region; other site
281310003737	heme exporter protein CcmB; Region: ccmB; TIGR01190
281310003738	heme exporter protein CcmC; Region: ccmC; TIGR01191
281310003739	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
281310003740	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
281310003741	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
281310003742	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
281310003743	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
281310003744	catalytic residues [active]
281310003745	central insert; other site
281310003746	NTHIp1260A; similar to: cytochrome c-type biogenesis protein CcmH precursor, N-terminal fragment
281310003747	NTHIp1260B; similar to: cytochrome c-type biogenesis protein CcmH precursor, C-terminal fragment
281310003748	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
281310003749	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
281310003750	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
281310003751	nucleotide binding pocket [chemical binding]; other site
281310003752	K-X-D-G motif; other site
281310003753	catalytic site [active]
281310003754	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
281310003755	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
281310003756	Helix-hairpin-helix motif; Region: HHH; pfam00633
281310003757	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
281310003758	Dimer interface [polypeptide binding]; other site
281310003759	BRCT sequence motif; other site
281310003760	cell division protein ZipA; Provisional; Region: PRK01741
281310003761	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
281310003762	FtsZ protein binding site [polypeptide binding]; other site
281310003763	putative sulfate transport protein CysZ; Validated; Region: PRK04949
281310003764	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
281310003765	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
281310003766	dimer interface [polypeptide binding]; other site
281310003767	pyridoxal 5'-phosphate binding site [chemical binding]; other site
281310003768	catalytic residue [active]
281310003769	NTHIp1270A; similar to: conserved hypothetical metabolite transport protein, N-terminal fragment
281310003770	NTHIp1270B; similar to: conserved hypothetical metabolite transport protein, C-terminal fragment
281310003771	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
281310003772	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
281310003773	putative active site [active]
281310003774	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
281310003775	putative dimerization interface [polypeptide binding]; other site
281310003776	Transcriptional regulators [Transcription]; Region: PurR; COG1609
281310003777	putative ligand binding site [chemical binding]; other site
281310003778	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
281310003779	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
281310003780	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
281310003781	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
281310003782	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
281310003783	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
281310003784	pyridoxal 5'-phosphate binding site [chemical binding]; other site
281310003785	homodimer interface [polypeptide binding]; other site
281310003786	catalytic residue [active]
281310003787	xylose isomerase; Provisional; Region: PRK05474
281310003788	xylose isomerase; Region: xylose_isom_A; TIGR02630
281310003789	D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809
281310003790	N- and C-terminal domain interface [polypeptide binding]; other site
281310003791	D-xylulose kinase; Region: XylB; TIGR01312
281310003792	active site
281310003793	MgATP binding site [chemical binding]; other site
281310003794	catalytic site [active]
281310003795	metal binding site [ion binding]; metal-binding site
281310003796	xylulose binding site [chemical binding]; other site
281310003797	putative homodimer interface [polypeptide binding]; other site
281310003798	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
281310003799	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
281310003800	NADP binding site [chemical binding]; other site
281310003801	homopentamer interface [polypeptide binding]; other site
281310003802	substrate binding site [chemical binding]; other site
281310003803	active site
281310003804	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
281310003805	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
281310003806	catalytic residues [active]
281310003807	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
281310003808	intersubunit interface [polypeptide binding]; other site
281310003809	active site
281310003810	catalytic residue [active]
281310003811	Mg chelatase-related protein; Region: TIGR00368
281310003812	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
281310003813	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
281310003814	Walker A motif; other site
281310003815	ATP binding site [chemical binding]; other site
281310003816	Walker B motif; other site
281310003817	arginine finger; other site
281310003818	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
281310003819	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
281310003820	G1 box; other site
281310003821	GTP/Mg2+ binding site [chemical binding]; other site
281310003822	Switch I region; other site
281310003823	G2 box; other site
281310003824	G3 box; other site
281310003825	Switch II region; other site
281310003826	G4 box; other site
281310003827	G5 box; other site
281310003828	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
281310003829	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
281310003830	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
281310003831	Walker A/P-loop; other site
281310003832	ATP binding site [chemical binding]; other site
281310003833	Q-loop/lid; other site
281310003834	ABC transporter signature motif; other site
281310003835	Walker B; other site
281310003836	D-loop; other site
281310003837	H-loop/switch region; other site
281310003838	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
281310003839	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
281310003840	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
281310003841	Walker A/P-loop; other site
281310003842	ATP binding site [chemical binding]; other site
281310003843	Q-loop/lid; other site
281310003844	ABC transporter signature motif; other site
281310003845	Walker B; other site
281310003846	D-loop; other site
281310003847	H-loop/switch region; other site
281310003848	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
281310003849	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
281310003850	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
281310003851	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310003852	dimer interface [polypeptide binding]; other site
281310003853	conserved gate region; other site
281310003854	ABC-ATPase subunit interface; other site
281310003855	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
281310003856	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310003857	dimer interface [polypeptide binding]; other site
281310003858	conserved gate region; other site
281310003859	putative PBP binding loops; other site
281310003860	ABC-ATPase subunit interface; other site
281310003861	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
281310003862	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
281310003863	peptide binding site [polypeptide binding]; other site
281310003864	transaldolase-like protein; Provisional; Region: PTZ00411
281310003865	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
281310003866	active site
281310003867	dimer interface [polypeptide binding]; other site
281310003868	catalytic residue [active]
281310003869	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
281310003870	Carbon starvation protein CstA; Region: CstA; pfam02554
281310003871	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
281310003872	mraZ protein; Region: TIGR00242
281310003873	MraZ protein; Region: MraZ; pfam02381
281310003874	MraZ protein; Region: MraZ; pfam02381
281310003875	16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006
281310003876	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
281310003877	Cell division protein [Cell division and chromosome partitioning]; Region: FtsL; COG3116
281310003878	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
281310003879	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
281310003880	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
281310003881	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
281310003882	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
281310003883	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
281310003884	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
281310003885	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
281310003886	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
281310003887	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
281310003888	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
281310003889	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
281310003890	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
281310003891	Mg++ binding site [ion binding]; other site
281310003892	putative catalytic motif [active]
281310003893	putative substrate binding site [chemical binding]; other site
281310003894	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
281310003895	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
281310003896	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
281310003897	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
281310003898	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
281310003899	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
281310003900	active site
281310003901	homodimer interface [polypeptide binding]; other site
281310003902	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
281310003903	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
281310003904	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
281310003905	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
281310003906	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
281310003907	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
281310003908	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
281310003909	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
281310003910	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
281310003911	Cell division protein FtsQ; Region: FtsQ; pfam03799
281310003912	cell division protein FtsA; Region: ftsA; TIGR01174
281310003913	Cell division protein FtsA; Region: FtsA; smart00842
281310003914	Cell division protein FtsA; Region: FtsA; pfam14450
281310003915	cell division protein FtsZ; Validated; Region: PRK09330
281310003916	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
281310003917	nucleotide binding site [chemical binding]; other site
281310003918	SulA interaction site; other site
281310003919	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
281310003920	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
281310003921	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
281310003922	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
281310003923	Prephenate dehydratase; Region: PDT; pfam00800
281310003924	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
281310003925	putative L-Phe binding site [chemical binding]; other site
281310003926	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
281310003927	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
281310003928	active site
281310003929	phosphorylation site [posttranslational modification]
281310003930	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
281310003931	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
281310003932	Walker A/P-loop; other site
281310003933	ATP binding site [chemical binding]; other site
281310003934	Q-loop/lid; other site
281310003935	ABC transporter signature motif; other site
281310003936	Walker B; other site
281310003937	D-loop; other site
281310003938	H-loop/switch region; other site
281310003939	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
281310003940	OstA-like protein; Region: OstA; cl00844
281310003941	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
281310003942	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
281310003943	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3028
281310003944	peptidase PmbA; Provisional; Region: PRK11040
281310003945	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
281310003946	active site
281310003947	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
281310003948	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
281310003949	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
281310003950	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
281310003951	FeS/SAM binding site; other site
281310003952	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
281310003953	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
281310003954	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
281310003955	Walker A/P-loop; other site
281310003956	ATP binding site [chemical binding]; other site
281310003957	Q-loop/lid; other site
281310003958	ABC transporter signature motif; other site
281310003959	Walker B; other site
281310003960	D-loop; other site
281310003961	H-loop/switch region; other site
281310003962	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
281310003963	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
281310003964	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
281310003965	Walker A/P-loop; other site
281310003966	ATP binding site [chemical binding]; other site
281310003967	Q-loop/lid; other site
281310003968	ABC transporter signature motif; other site
281310003969	Walker B; other site
281310003970	D-loop; other site
281310003971	H-loop/switch region; other site
281310003972	thioredoxin reductase; Provisional; Region: PRK10262
281310003973	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
281310003974	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
281310003975	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
281310003976	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
281310003977	ferrochelatase; Region: hemH; TIGR00109
281310003978	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
281310003979	C-terminal domain interface [polypeptide binding]; other site
281310003980	active site
281310003981	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
281310003982	active site
281310003983	N-terminal domain interface [polypeptide binding]; other site
281310003984	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
281310003985	CoenzymeA binding site [chemical binding]; other site
281310003986	subunit interaction site [polypeptide binding]; other site
281310003987	PHB binding site; other site
281310003988	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
281310003989	FAD binding domain; Region: FAD_binding_4; pfam01565
281310003990	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
281310003991	outer membrane protein A; Reviewed; Region: PRK10808
281310003992	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
281310003993	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
281310003994	ligand binding site [chemical binding]; other site
281310003995	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
281310003996	putative GSH binding site [chemical binding]; other site
281310003997	catalytic residues [active]
281310003998	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
281310003999	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
281310004000	pyridoxal 5'-phosphate binding site [chemical binding]; other site
281310004001	homodimer interface [polypeptide binding]; other site
281310004002	catalytic residue [active]
281310004003	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
281310004004	homodimer interface [polypeptide binding]; other site
281310004005	substrate-cofactor binding pocket; other site
281310004006	pyridoxal 5'-phosphate binding site [chemical binding]; other site
281310004007	catalytic residue [active]
281310004008	hypothetical protein; Provisional; Region: PRK05423
281310004009	hypothetical protein; Provisional; Region: PRK07101
281310004010	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
281310004011	substrate-cofactor binding pocket; other site
281310004012	para-aminobenzoate synthase component I; Validated; Region: PRK07093
281310004013	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
281310004014	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
281310004015	Glutamine amidotransferase class-I; Region: GATase; pfam00117
281310004016	glutamine binding [chemical binding]; other site
281310004017	catalytic triad [active]
281310004018	S-adenosylmethionine synthetase; Validated; Region: PRK05250
281310004019	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
281310004020	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
281310004021	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
281310004022	hypothetical protein; Provisional; Region: PRK04860
281310004023	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
281310004024	Opacity family porin protein; Region: Opacity; pfam02462
281310004025	YadA-like C-terminal region; Region: YadA; pfam03895
281310004026	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310004027	dimer interface [polypeptide binding]; other site
281310004028	conserved gate region; other site
281310004029	putative PBP binding loops; other site
281310004030	ABC-ATPase subunit interface; other site
281310004031	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
281310004032	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310004033	dimer interface [polypeptide binding]; other site
281310004034	conserved gate region; other site
281310004035	putative PBP binding loops; other site
281310004036	ABC-ATPase subunit interface; other site
281310004037	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
281310004038	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
281310004039	substrate binding pocket [chemical binding]; other site
281310004040	membrane-bound complex binding site; other site
281310004041	hinge residues; other site
281310004042	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
281310004043	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
281310004044	Walker A/P-loop; other site
281310004045	ATP binding site [chemical binding]; other site
281310004046	Q-loop/lid; other site
281310004047	ABC transporter signature motif; other site
281310004048	Walker B; other site
281310004049	D-loop; other site
281310004050	H-loop/switch region; other site
281310004051	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
281310004052	dimer interface [polypeptide binding]; other site
281310004053	active site
281310004054	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
281310004055	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636
281310004056	DNA binding site [nucleotide binding]
281310004057	active site
281310004058	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
281310004059	DNA binding site [nucleotide binding]
281310004060	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
281310004061	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
281310004062	Walker A/P-loop; other site
281310004063	ATP binding site [chemical binding]; other site
281310004064	Q-loop/lid; other site
281310004065	ABC transporter signature motif; other site
281310004066	Walker B; other site
281310004067	D-loop; other site
281310004068	H-loop/switch region; other site
281310004069	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
281310004070	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
281310004071	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
281310004072	Walker A/P-loop; other site
281310004073	ATP binding site [chemical binding]; other site
281310004074	Q-loop/lid; other site
281310004075	ABC transporter signature motif; other site
281310004076	Walker B; other site
281310004077	D-loop; other site
281310004078	H-loop/switch region; other site
281310004079	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
281310004080	dipeptide transporter; Provisional; Region: PRK10913
281310004081	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
281310004082	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310004083	dimer interface [polypeptide binding]; other site
281310004084	conserved gate region; other site
281310004085	putative PBP binding loops; other site
281310004086	ABC-ATPase subunit interface; other site
281310004087	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
281310004088	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310004089	dimer interface [polypeptide binding]; other site
281310004090	conserved gate region; other site
281310004091	putative PBP binding loops; other site
281310004092	ABC-ATPase subunit interface; other site
281310004093	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
281310004094	Part of AAA domain; Region: AAA_19; pfam13245
281310004095	Family description; Region: UvrD_C_2; pfam13538
281310004096	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
281310004097	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
281310004098	FeS/SAM binding site; other site
281310004099	6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039
281310004100	active site
281310004101	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
281310004102	Ligand Binding Site [chemical binding]; other site
281310004103	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
281310004104	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
281310004105	homodimer interface [polypeptide binding]; other site
281310004106	substrate-cofactor binding pocket; other site
281310004107	catalytic residue [active]
281310004108	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
281310004109	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
281310004110	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
281310004111	dimerization interface [polypeptide binding]; other site
281310004112	substrate binding pocket [chemical binding]; other site
281310004113	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
281310004114	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
281310004115	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
281310004116	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
281310004117	CoA-ligase; Region: Ligase_CoA; pfam00549
281310004118	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
281310004119	CoA binding domain; Region: CoA_binding; pfam02629
281310004120	CoA-ligase; Region: Ligase_CoA; pfam00549
281310004121	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
281310004122	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
281310004123	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
281310004124	RNA binding surface [nucleotide binding]; other site
281310004125	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
281310004126	probable active site [active]
281310004127	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
281310004128	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
281310004129	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
281310004130	substrate binding site [chemical binding]; other site
281310004131	dimerization interface [polypeptide binding]; other site
281310004132	HemK family putative methylases; Region: hemK_fam; TIGR00536
281310004133	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
281310004134	S-adenosylmethionine binding site [chemical binding]; other site
281310004135	hypothetical protein; Provisional; Region: PRK04946
281310004136	Smr domain; Region: Smr; pfam01713
281310004137	phosphate acetyltransferase; Reviewed; Region: PRK05632
281310004138	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
281310004139	DRTGG domain; Region: DRTGG; pfam07085
281310004140	phosphate acetyltransferase; Region: pta; TIGR00651
281310004141	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
281310004142	propionate/acetate kinase; Provisional; Region: PRK12379
281310004143	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3092
281310004144	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
281310004145	Colicin V production protein; Region: Colicin_V; cl00567
281310004146	amidophosphoribosyltransferase; Provisional; Region: PRK09246
281310004147	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
281310004148	active site
281310004149	tetramer interface [polypeptide binding]; other site
281310004150	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
281310004151	active site
281310004152	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
281310004153	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
281310004154	NAD(P) binding site [chemical binding]; other site
281310004155	active site
281310004156	arginine repressor; Provisional; Region: PRK05066
281310004157	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
281310004158	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
281310004159	malate dehydrogenase; Provisional; Region: PRK05086
281310004160	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
281310004161	NAD binding site [chemical binding]; other site
281310004162	dimerization interface [polypeptide binding]; other site
281310004163	Substrate binding site [chemical binding]; other site
281310004164	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
281310004165	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
281310004166	dimer interface [polypeptide binding]; other site
281310004167	putative anticodon binding site; other site
281310004168	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
281310004169	motif 1; other site
281310004170	active site
281310004171	motif 2; other site
281310004172	motif 3; other site
281310004173	peptide chain release factor 2; Provisional; Region: PRK08787
281310004174	This domain is found in peptide chain release factors; Region: PCRF; smart00937
281310004175	RF-1 domain; Region: RF-1; pfam00472
281310004176	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
281310004177	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
281310004178	dimerization domain [polypeptide binding]; other site
281310004179	dimer interface [polypeptide binding]; other site
281310004180	catalytic residues [active]
281310004181	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
281310004182	DHH family; Region: DHH; pfam01368
281310004183	DHHA1 domain; Region: DHHA1; pfam02272
281310004184	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
281310004185	catalytic residues [active]
281310004186	hinge region; other site
281310004187	alpha helical domain; other site
281310004188	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
281310004189	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
281310004190	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
281310004191	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
281310004192	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
281310004193	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
281310004194	L-lactate transport; Region: lctP; TIGR00795
281310004195	NTHIp1392A; similar to: cytidylate kinase, N-terminal fragment
281310004196	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
281310004197	AMP binding site [chemical binding]; other site
281310004198	metal binding site [ion binding]; metal-binding site
281310004199	active site
281310004200	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
281310004201	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
281310004202	dimerization interface 3.5A [polypeptide binding]; other site
281310004203	active site
281310004204	conserved hypothetical integral membrane protein; Region: TIGR00698
281310004205	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167
281310004206	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
281310004207	Walker A/P-loop; other site
281310004208	ATP binding site [chemical binding]; other site
281310004209	Q-loop/lid; other site
281310004210	ABC transporter signature motif; other site
281310004211	Walker B; other site
281310004212	D-loop; other site
281310004213	H-loop/switch region; other site
281310004214	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170
281310004215	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
281310004216	Walker A/P-loop; other site
281310004217	ATP binding site [chemical binding]; other site
281310004218	Q-loop/lid; other site
281310004219	ABC transporter signature motif; other site
281310004220	Walker B; other site
281310004221	D-loop; other site
281310004222	H-loop/switch region; other site
281310004223	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
281310004224	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171
281310004225	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
281310004226	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310004227	dimer interface [polypeptide binding]; other site
281310004228	conserved gate region; other site
281310004229	putative PBP binding loops; other site
281310004230	ABC-ATPase subunit interface; other site
281310004231	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168
281310004232	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310004233	dimer interface [polypeptide binding]; other site
281310004234	conserved gate region; other site
281310004235	putative PBP binding loops; other site
281310004236	ABC-ATPase subunit interface; other site
281310004237	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
281310004238	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
281310004239	peptide binding site [polypeptide binding]; other site
281310004240	Predicted ATPase [General function prediction only]; Region: COG3106
281310004241	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
281310004242	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
281310004243	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
281310004244	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
281310004245	DNA binding site [nucleotide binding]
281310004246	domain linker motif; other site
281310004247	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
281310004248	dimerization interface [polypeptide binding]; other site
281310004249	ligand binding site [chemical binding]; other site
281310004250	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
281310004251	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
281310004252	trimer interface [polypeptide binding]; other site
281310004253	active site
281310004254	substrate binding site [chemical binding]; other site
281310004255	CoA binding site [chemical binding]; other site
281310004256	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
281310004257	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
281310004258	GDP-binding site [chemical binding]; other site
281310004259	ACT binding site; other site
281310004260	IMP binding site; other site
281310004261	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
281310004262	substrate binding site [chemical binding]; other site
281310004263	nucleotide binding site [chemical binding]; other site
281310004264	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
281310004265	dimer interface [polypeptide binding]; other site
281310004266	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
281310004267	5S rRNA interface [nucleotide binding]; other site
281310004268	CTC domain interface [polypeptide binding]; other site
281310004269	L16 interface [polypeptide binding]; other site
281310004270	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
281310004271	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
281310004272	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
281310004273	Protein of unknown function (DUF1043); Region: DUF1043; pfam06295
281310004274	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
281310004275	homotrimer interaction site [polypeptide binding]; other site
281310004276	putative active site [active]
281310004277	YwiC-like protein; Region: YwiC; pfam14256
281310004278	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
281310004279	Sel1-like repeats; Region: SEL1; smart00671
281310004280	Sel1-like repeats; Region: SEL1; smart00671
281310004281	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
281310004282	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
281310004283	DNA binding residues [nucleotide binding]
281310004284	dimer interface [polypeptide binding]; other site
281310004285	putative metal binding site [ion binding]; other site
281310004286	ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
281310004287	cobalt transport protein CbiM; Validated; Region: PRK06265
281310004288	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
281310004289	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
281310004290	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
281310004291	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
281310004292	Walker A/P-loop; other site
281310004293	ATP binding site [chemical binding]; other site
281310004294	Q-loop/lid; other site
281310004295	ABC transporter signature motif; other site
281310004296	Walker B; other site
281310004297	D-loop; other site
281310004298	H-loop/switch region; other site
281310004299	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
281310004300	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
281310004301	pyridoxal 5'-phosphate binding site [chemical binding]; other site
281310004302	homodimer interface [polypeptide binding]; other site
281310004303	catalytic residue [active]
281310004304	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026
281310004305	ATP-grasp domain; Region: ATP-grasp; pfam02222
281310004306	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
281310004307	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
281310004308	HicB family; Region: HicB; pfam05534
281310004309	aminopeptidase N; Provisional; Region: pepN; PRK14015
281310004310	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
281310004311	active site
281310004312	Zn binding site [ion binding]; other site
281310004313	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
281310004314	Lumazine binding domain; Region: Lum_binding; pfam00677
281310004315	Lumazine binding domain; Region: Lum_binding; pfam00677
281310004316	multidrug efflux protein; Reviewed; Region: PRK01766
281310004317	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
281310004318	cation binding site [ion binding]; other site
281310004319	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
281310004320	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
281310004321	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
281310004322	active site
281310004323	HIGH motif; other site
281310004324	dimer interface [polypeptide binding]; other site
281310004325	KMSKS motif; other site
281310004326	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
281310004327	RNA binding surface [nucleotide binding]; other site
281310004328	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
281310004329	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
281310004330	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
281310004331	active site
281310004332	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
281310004333	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
281310004334	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
281310004335	outer membrane lipoprotein LolB; Region: lolB; TIGR00548
281310004336	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
281310004337	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
281310004338	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
281310004339	active site
281310004340	NTP binding site [chemical binding]; other site
281310004341	metal binding triad [ion binding]; metal-binding site
281310004342	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
281310004343	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
281310004344	Zn2+ binding site [ion binding]; other site
281310004345	Mg2+ binding site [ion binding]; other site
281310004346	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
281310004347	Bacterial SH3 domain homologues; Region: SH3b; smart00287
281310004348	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
281310004349	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
281310004350	TIGR00153 family protein; Region: TIGR00153
281310004351	Predicted membrane protein [Function unknown]; Region: COG2259
281310004352	Uncharacterized low-complexity protein [Function unknown]; Region: COG3767
281310004353	Protein of unknown function (DUF692); Region: DUF692; pfam05114
281310004354	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3219
281310004355	Homeodomain-like domain; Region: HTH_23; pfam13384
281310004356	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
281310004357	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
281310004358	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
281310004359	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
281310004360	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
281310004361	Uncharacterized conserved protein [Function unknown]; Region: COG3025
281310004362	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
281310004363	putative active site [active]
281310004364	putative metal binding residues [ion binding]; other site
281310004365	signature motif; other site
281310004366	putative triphosphate binding site [ion binding]; other site
281310004367	DNA repair protein RadA; Region: sms; TIGR00416
281310004368	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
281310004369	Walker A motif/ATP binding site; other site
281310004370	ATP binding site [chemical binding]; other site
281310004371	Walker B motif; other site
281310004372	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
281310004373	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
281310004374	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
281310004375	dimerization interface [polypeptide binding]; other site
281310004376	putative DNA binding site [nucleotide binding]; other site
281310004377	putative Zn2+ binding site [ion binding]; other site
281310004378	AsnC family; Region: AsnC_trans_reg; pfam01037
281310004379	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
281310004380	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
281310004381	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
281310004382	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
281310004383	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
281310004384	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
281310004385	recombination factor protein RarA; Reviewed; Region: PRK13342
281310004386	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
281310004387	Walker A motif; other site
281310004388	ATP binding site [chemical binding]; other site
281310004389	Walker B motif; other site
281310004390	arginine finger; other site
281310004391	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
281310004392	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
281310004393	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
281310004394	cofactor binding site; other site
281310004395	DNA binding site [nucleotide binding]
281310004396	substrate interaction site [chemical binding]; other site
281310004397	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
281310004398	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
281310004399	hinge; other site
281310004400	active site
281310004401	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
281310004402	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
281310004403	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
281310004404	putative active site [active]
281310004405	putative substrate binding site [chemical binding]; other site
281310004406	putative cosubstrate binding site; other site
281310004407	catalytic site [active]
281310004408	DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916
281310004409	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
281310004410	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
281310004411	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06882
281310004412	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
281310004413	PYR/PP interface [polypeptide binding]; other site
281310004414	dimer interface [polypeptide binding]; other site
281310004415	TPP binding site [chemical binding]; other site
281310004416	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
281310004417	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
281310004418	TPP-binding site [chemical binding]; other site
281310004419	dimer interface [polypeptide binding]; other site
281310004420	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
281310004421	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
281310004422	putative valine binding site [chemical binding]; other site
281310004423	dimer interface [polypeptide binding]; other site
281310004424	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
281310004425	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
281310004426	arginyl-tRNA synthetase; Region: argS; TIGR00456
281310004427	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
281310004428	active site
281310004429	HIGH motif; other site
281310004430	KMSK motif region; other site
281310004431	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
281310004432	tRNA binding surface [nucleotide binding]; other site
281310004433	anticodon binding site; other site
281310004434	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
281310004435	putative metal binding site [ion binding]; other site
281310004436	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
281310004437	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
281310004438	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
281310004439	active site
281310004440	NTHIp1474_1B; similar to: IS1016-V6 protein homolog, C-terminal fragment
281310004441	NTHIp1474_1A; similar to: IS1016-V6 protein homolog, N-terminal fragment
281310004442	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
281310004443	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
281310004444	active site
281310004445	dimer interface [polypeptide binding]; other site
281310004446	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
281310004447	dimer interface [polypeptide binding]; other site
281310004448	active site
281310004449	alanine racemase; Reviewed; Region: alr; PRK00053
281310004450	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
281310004451	active site
281310004452	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
281310004453	substrate binding site [chemical binding]; other site
281310004454	catalytic residues [active]
281310004455	dimer interface [polypeptide binding]; other site
281310004456	replicative DNA helicase; Validated; Region: PRK06904
281310004457	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
281310004458	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
281310004459	Walker A motif; other site
281310004460	ATP binding site [chemical binding]; other site
281310004461	Walker B motif; other site
281310004462	DNA binding loops [nucleotide binding]
281310004463	pyruvate kinase; Provisional; Region: PRK05826
281310004464	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
281310004465	domain interfaces; other site
281310004466	active site
281310004467	integrase; Provisional; Region: PRK09692
281310004468	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
281310004469	active site
281310004470	Int/Topo IB signature motif; other site
281310004471	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
281310004472	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
281310004473	cofactor binding site; other site
281310004474	DNA binding site [nucleotide binding]
281310004475	substrate interaction site [chemical binding]; other site
281310004476	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
281310004477	Putative exonuclease, RdgC; Region: RdgC; pfam04381
281310004478	hypothetical protein; Provisional; Region: PRK09946
281310004479	hypothetical protein; Provisional; Region: PRK09946
281310004480	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
281310004481	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
281310004482	dimer interface [polypeptide binding]; other site
281310004483	ssDNA binding site [nucleotide binding]; other site
281310004484	tetramer (dimer of dimers) interface [polypeptide binding]; other site
281310004485	RecT family; Region: RecT; cl04285
281310004486	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
281310004487	DNA methylase; Region: N6_N4_Mtase; pfam01555
281310004488	HNH endonuclease; Region: HNH_3; pfam13392
281310004489	P22AR C-terminal domain; Region: P22_AR_C; pfam10548
281310004490	Uncharacterized conserved protein [Function unknown]; Region: COG4748
281310004491	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
281310004492	tRNA_anti-like; Region: tRNA_anti-like; pfam12869
281310004493	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
281310004494	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
281310004495	DNA binding residues [nucleotide binding]
281310004496	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
281310004497	YcfA-like protein; Region: YcfA; pfam07927
281310004498	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
281310004499	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
281310004500	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442
281310004501	Replication protein P; Region: Phage_lambda_P; pfam06992
281310004502	Helix-turn-helix domain; Region: HTH_36; pfam13730
281310004503	Helix-turn-helix domain; Region: HTH_39; pfam14090
281310004504	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
281310004505	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
281310004506	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
281310004507	non-specific DNA binding site [nucleotide binding]; other site
281310004508	salt bridge; other site
281310004509	sequence-specific DNA binding site [nucleotide binding]; other site
281310004510	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
281310004511	non-specific DNA binding site [nucleotide binding]; other site
281310004512	salt bridge; other site
281310004513	sequence-specific DNA binding site [nucleotide binding]; other site
281310004514	Predicted transcriptional regulator [Transcription]; Region: COG2932
281310004515	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
281310004516	Catalytic site [active]
281310004517	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
281310004518	Protein of unknown function (DUF2570); Region: DUF2570; pfam10828
281310004519	ParB-like nuclease domain; Region: ParBc; pfam02195
281310004520	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
281310004521	DNA methylase; Region: N6_N4_Mtase; cl17433
281310004522	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
281310004523	DNA binding residues [nucleotide binding]
281310004524	Phage terminase large subunit; Region: Terminase_3; cl12054
281310004525	Terminase-like family; Region: Terminase_6; pfam03237
281310004526	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
281310004527	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
281310004528	Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369
281310004529	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
281310004530	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566
281310004531	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
281310004532	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834
281310004533	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
281310004534	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
281310004535	Protein of unknown function (DUF3277); Region: DUF3277; pfam11681
281310004536	tape measure domain; Region: tape_meas_nterm; TIGR02675
281310004537	KilA-N domain; Region: KilA-N; pfam04383
281310004538	Baseplate J-like protein; Region: Baseplate_J; cl01294
281310004539	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
281310004540	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
281310004541	Phage Tail Collar Domain; Region: Collar; pfam07484
281310004542	NTHIp1557A; similar to:  integrase/recombinase, N-terminal fragment
281310004543	NTHIp1557B; similar to:  integrase/recombinase, central fragment
281310004544	NTHIp1557C; similar to:  integrase/recombinase, C-terminal fragment
281310004545	Protein of unknown function (DUF935); Region: DUF935; pfam06074
281310004546	DNA polymerase IV; Validated; Region: PRK02406
281310004547	Protein of unknown function, DUF462; Region: DUF462; cl01190
281310004548	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
281310004549	Sel1-like repeats; Region: SEL1; smart00671
281310004550	Sel1-like repeats; Region: SEL1; smart00671
281310004551	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
281310004552	Sel1-like repeats; Region: SEL1; smart00671
281310004553	Sel1-like repeats; Region: SEL1; smart00671
281310004554	Sel1-like repeats; Region: SEL1; smart00671
281310004555	Sel1-like repeats; Region: SEL1; smart00671
281310004556	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
281310004557	Sel1-like repeats; Region: SEL1; smart00671
281310004558	Sel1-like repeats; Region: SEL1; smart00671
281310004559	Sel1-like repeats; Region: SEL1; smart00671
281310004560	TPR repeat; Region: TPR_11; pfam13414
281310004561	Sel1-like repeats; Region: SEL1; smart00671
281310004562	Sel1-like repeats; Region: SEL1; smart00671
281310004563	Sel1-like repeats; Region: SEL1; smart00671
281310004564	peptide chain release factor 1; Validated; Region: prfA; PRK00591
281310004565	This domain is found in peptide chain release factors; Region: PCRF; smart00937
281310004566	RF-1 domain; Region: RF-1; pfam00472
281310004567	Predicted membrane protein/domain [Function unknown]; Region: COG1714
281310004568	HemK family putative methylases; Region: hemK_fam; TIGR00536
281310004569	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
281310004570	Uncharacterized conserved protein [Function unknown]; Region: COG2912
281310004571	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
281310004572	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
281310004573	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
281310004574	glycerate dehydrogenase; Provisional; Region: PRK06932
281310004575	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
281310004576	putative ligand binding site [chemical binding]; other site
281310004577	putative NAD binding site [chemical binding]; other site
281310004578	catalytic site [active]
281310004579	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
281310004580	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
281310004581	FtsX-like permease family; Region: FtsX; pfam02687
281310004582	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173
281310004583	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
281310004584	inhibitor-cofactor binding pocket; inhibition site
281310004585	pyridoxal 5'-phosphate binding site [chemical binding]; other site
281310004586	catalytic residue [active]
281310004587	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
281310004588	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
281310004589	substrate-cofactor binding pocket; other site
281310004590	pyridoxal 5'-phosphate binding site [chemical binding]; other site
281310004591	catalytic residue [active]
281310004592	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2830
281310004593	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
281310004594	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
281310004595	S-adenosylmethionine binding site [chemical binding]; other site
281310004596	AAA domain; Region: AAA_26; pfam13500
281310004597	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
281310004598	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
281310004599	ADP binding site [chemical binding]; other site
281310004600	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
281310004601	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
281310004602	Walker A/P-loop; other site
281310004603	ATP binding site [chemical binding]; other site
281310004604	Q-loop/lid; other site
281310004605	ABC transporter signature motif; other site
281310004606	Walker B; other site
281310004607	D-loop; other site
281310004608	H-loop/switch region; other site
281310004609	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
281310004610	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
281310004611	FtsX-like permease family; Region: FtsX; pfam02687
281310004612	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
281310004613	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
281310004614	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
281310004615	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
281310004616	Catalytic site [active]
281310004617	serine/threonine transporter SstT; Provisional; Region: PRK13628
281310004618	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
281310004619	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
281310004620	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
281310004621	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
281310004622	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
281310004623	putative FMN binding site [chemical binding]; other site
281310004624	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
281310004625	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
281310004626	tandem repeat interface [polypeptide binding]; other site
281310004627	oligomer interface [polypeptide binding]; other site
281310004628	active site residues [active]
281310004629	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
281310004630	tandem repeat interface [polypeptide binding]; other site
281310004631	oligomer interface [polypeptide binding]; other site
281310004632	active site residues [active]
281310004633	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
281310004634	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
281310004635	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
281310004636	active site
281310004637	metal-binding site
281310004638	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
281310004639	EamA-like transporter family; Region: EamA; pfam00892
281310004640	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
281310004641	active site
281310004642	ATP binding site [chemical binding]; other site
281310004643	Phosphotransferase enzyme family; Region: APH; pfam01636
281310004644	substrate binding site [chemical binding]; other site
281310004645	dimer interface [polypeptide binding]; other site
281310004646	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
281310004647	Uncharacterized conserved protein [Function unknown]; Region: COG4121
281310004648	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
281310004649	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
281310004650	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
281310004651	dimer interface [polypeptide binding]; other site
281310004652	active site
281310004653	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
281310004654	GSH binding site [chemical binding]; other site
281310004655	catalytic residues [active]
281310004656	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
281310004657	RimK-like ATP-grasp domain; Region: RimK; pfam08443
281310004658	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
281310004659	DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062
281310004660	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
281310004661	CAP-like domain; other site
281310004662	active site
281310004663	primary dimer interface [polypeptide binding]; other site
281310004664	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
281310004665	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
281310004666	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
281310004667	ATP binding site [chemical binding]; other site
281310004668	Mg2+ binding site [ion binding]; other site
281310004669	G-X-G motif; other site
281310004670	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
281310004671	anchoring element; other site
281310004672	dimer interface [polypeptide binding]; other site
281310004673	ATP binding site [chemical binding]; other site
281310004674	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
281310004675	active site
281310004676	putative metal-binding site [ion binding]; other site
281310004677	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
281310004678	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
281310004679	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
281310004680	putative acyl-acceptor binding pocket; other site
281310004681	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
281310004682	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
281310004683	putative ribose interaction site [chemical binding]; other site
281310004684	putative ADP binding site [chemical binding]; other site
281310004685	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
281310004686	active site
281310004687	nucleotide binding site [chemical binding]; other site
281310004688	HIGH motif; other site
281310004689	KMSKS motif; other site
281310004690	NTHIp1609A; similar to: Type I restriction enzyme R protein, N-terminal fragment
281310004691	Abortive infection C-terminus; Region: Abi_C; pfam14355
281310004692	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
281310004693	H-loop/switch region; other site
281310004694	ABC transporter; Region: ABC_tran_2; pfam12848
281310004695	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
281310004696	Walker B; other site
281310004697	D-loop; other site
281310004698	H-loop/switch region; other site
281310004699	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
281310004700	active site clefts [active]
281310004701	zinc binding site [ion binding]; other site
281310004702	dimer interface [polypeptide binding]; other site
281310004703	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
281310004704	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
281310004705	putative anticodon binding site; other site
281310004706	putative dimer interface [polypeptide binding]; other site
281310004707	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
281310004708	homodimer interface [polypeptide binding]; other site
281310004709	motif 1; other site
281310004710	motif 2; other site
281310004711	active site
281310004712	motif 3; other site
281310004713	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
281310004714	homopentamer interface [polypeptide binding]; other site
281310004715	active site
281310004716	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
281310004717	putative RNA binding site [nucleotide binding]; other site
281310004718	thiamine-monophosphate kinase; Region: thiL; TIGR01379
281310004719	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
281310004720	ATP binding site [chemical binding]; other site
281310004721	dimerization interface [polypeptide binding]; other site
281310004722	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
281310004723	tetramer interfaces [polypeptide binding]; other site
281310004724	binuclear metal-binding site [ion binding]; other site
281310004725	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
281310004726	dihydrodipicolinate reductase; Region: dapB; TIGR00036
281310004727	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
281310004728	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
281310004729	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
281310004730	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
281310004731	catalytic loop [active]
281310004732	iron binding site [ion binding]; other site
281310004733	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
281310004734	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
281310004735	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
281310004736	dimer interface [polypeptide binding]; other site
281310004737	motif 1; other site
281310004738	active site
281310004739	motif 2; other site
281310004740	motif 3; other site
281310004741	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
281310004742	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
281310004743	putative tRNA-binding site [nucleotide binding]; other site
281310004744	B3/4 domain; Region: B3_4; pfam03483
281310004745	tRNA synthetase B5 domain; Region: B5; smart00874
281310004746	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
281310004747	dimer interface [polypeptide binding]; other site
281310004748	motif 1; other site
281310004749	motif 3; other site
281310004750	motif 2; other site
281310004751	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
281310004752	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
281310004753	IHF dimer interface [polypeptide binding]; other site
281310004754	IHF - DNA interface [nucleotide binding]; other site
281310004755	NlpC/P60 family; Region: NLPC_P60; pfam00877
281310004756	Predicted transcriptional regulator [Transcription]; Region: COG2378
281310004757	WYL domain; Region: WYL; pfam13280
281310004758	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
281310004759	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
281310004760	NAD-dependent deacetylase; Provisional; Region: PRK00481
281310004761	NAD+ binding site [chemical binding]; other site
281310004762	substrate binding site [chemical binding]; other site
281310004763	Zn binding site [ion binding]; other site
281310004764	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
281310004765	Fic/DOC family; Region: Fic; pfam02661
281310004766	Fic/DOC family; Region: Fic; cl00960
281310004767	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
281310004768	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
281310004769	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296
281310004770	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
281310004771	active site
281310004772	Restriction endonuclease; Region: Mrr_cat; pfam04471
281310004773	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
281310004774	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
281310004775	Walker A motif; other site
281310004776	ATP binding site [chemical binding]; other site
281310004777	Walker B motif; other site
281310004778	arginine finger; other site
281310004779	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
281310004780	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
281310004781	Walker A motif; other site
281310004782	ATP binding site [chemical binding]; other site
281310004783	Walker B motif; other site
281310004784	arginine finger; other site
281310004785	Sulfatase; Region: Sulfatase; cl17466
281310004786	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
281310004787	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
281310004788	active site
281310004789	phosphate binding residues; other site
281310004790	catalytic residues [active]
281310004791	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
281310004792	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
281310004793	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
281310004794	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
281310004795	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
281310004796	23S rRNA binding site [nucleotide binding]; other site
281310004797	L21 binding site [polypeptide binding]; other site
281310004798	L13 binding site [polypeptide binding]; other site
281310004799	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
281310004800	Family description; Region: UvrD_C_2; pfam13538
281310004801	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
281310004802	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
281310004803	AAA domain; Region: AAA_30; pfam13604
281310004804	Family description; Region: UvrD_C_2; pfam13538
281310004805	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
281310004806	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
281310004807	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
281310004808	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
281310004809	active site 1 [active]
281310004810	dimer interface [polypeptide binding]; other site
281310004811	active site 2 [active]
281310004812	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
281310004813	ATP binding site [chemical binding]; other site
281310004814	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
281310004815	16S/18S rRNA binding site [nucleotide binding]; other site
281310004816	S13e-L30e interaction site [polypeptide binding]; other site
281310004817	25S rRNA binding site [nucleotide binding]; other site
281310004818	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676
281310004819	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
281310004820	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
281310004821	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
281310004822	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
281310004823	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
281310004824	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
281310004825	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
281310004826	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
281310004827	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
281310004828	S-adenosylmethionine binding site [chemical binding]; other site
281310004829	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
281310004830	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
281310004831	Walker A motif; other site
281310004832	ATP binding site [chemical binding]; other site
281310004833	Walker B motif; other site
281310004834	arginine finger; other site
281310004835	Peptidase family M41; Region: Peptidase_M41; pfam01434
281310004836	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
281310004837	dihydropteroate synthase; Region: DHPS; TIGR01496
281310004838	substrate binding pocket [chemical binding]; other site
281310004839	dimer interface [polypeptide binding]; other site
281310004840	inhibitor binding site; inhibition site
281310004841	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
281310004842	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
281310004843	active site
281310004844	substrate binding site [chemical binding]; other site
281310004845	metal binding site [ion binding]; metal-binding site
281310004846	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
281310004847	catalytic core [active]
281310004848	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
281310004849	NTHIp1672A; similar to: surface protein, autotransporter domain, C-terminal fragment
281310004850	RNA polymerase sigma factor; Provisional; Region: PRK12530
281310004851	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
281310004852	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
281310004853	DNA binding residues [nucleotide binding]
281310004854	Putative zinc-finger; Region: zf-HC2; pfam13490
281310004855	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
281310004856	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
281310004857	EamA-like transporter family; Region: EamA; cl17759
281310004858	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
281310004859	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
281310004860	SelR domain; Region: SelR; pfam01641
281310004861	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
281310004862	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
281310004863	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
281310004864	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
281310004865	catalytic residues [active]
281310004866	dsDNA-mimic protein; Reviewed; Region: PRK05094
281310004867	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
281310004868	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
281310004869	ATP binding site [chemical binding]; other site
281310004870	substrate interface [chemical binding]; other site
281310004871	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
281310004872	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
281310004873	dimer interface [polypeptide binding]; other site
281310004874	putative functional site; other site
281310004875	putative MPT binding site; other site
281310004876	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
281310004877	homodecamer interface [polypeptide binding]; other site
281310004878	GTP cyclohydrolase I; Provisional; Region: PLN03044
281310004879	active site
281310004880	putative catalytic site residues [active]
281310004881	zinc binding site [ion binding]; other site
281310004882	GTP-CH-I/GFRP interaction surface; other site
281310004883	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100
281310004884	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
281310004885	AAA domain; Region: AAA_26; pfam13500
281310004886	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
281310004887	FAD binding site [chemical binding]; other site
281310004888	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
281310004889	23S rRNA interface [nucleotide binding]; other site
281310004890	L3 interface [polypeptide binding]; other site
281310004891	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
281310004892	stringent starvation protein A; Provisional; Region: sspA; PRK09481
281310004893	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
281310004894	C-terminal domain interface [polypeptide binding]; other site
281310004895	putative GSH binding site (G-site) [chemical binding]; other site
281310004896	dimer interface [polypeptide binding]; other site
281310004897	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
281310004898	dimer interface [polypeptide binding]; other site
281310004899	N-terminal domain interface [polypeptide binding]; other site
281310004900	Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969
281310004901	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
281310004902	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
281310004903	TPP-binding site; other site
281310004904	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
281310004905	PYR/PP interface [polypeptide binding]; other site
281310004906	dimer interface [polypeptide binding]; other site
281310004907	TPP binding site [chemical binding]; other site
281310004908	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
281310004909	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
281310004910	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
281310004911	substrate binding pocket [chemical binding]; other site
281310004912	chain length determination region; other site
281310004913	substrate-Mg2+ binding site; other site
281310004914	catalytic residues [active]
281310004915	aspartate-rich region 1; other site
281310004916	active site lid residues [active]
281310004917	aspartate-rich region 2; other site
281310004918	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
281310004919	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
281310004920	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
281310004921	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
281310004922	Ligand Binding Site [chemical binding]; other site
281310004923	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
281310004924	active site residue [active]
281310004925	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098
281310004926	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
281310004927	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
281310004928	probable active site [active]
281310004929	Uncharacterized protein family (UPF0181); Region: UPF0181; pfam03701
281310004930	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
281310004931	DNA-binding site [nucleotide binding]; DNA binding site
281310004932	RNA-binding motif; other site
281310004933	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
281310004934	putative deacylase active site [active]
281310004935	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06901
281310004936	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
281310004937	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
281310004938	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
281310004939	substrate binding site [chemical binding]; other site
281310004940	active site
281310004941	catalytic residues [active]
281310004942	heterodimer interface [polypeptide binding]; other site
281310004943	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
281310004944	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
281310004945	pyridoxal 5'-phosphate binding site [chemical binding]; other site
281310004946	catalytic residue [active]
281310004947	malonic semialdehyde reductase; Provisional; Region: PRK10538
281310004948	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
281310004949	putative NAD(P) binding site [chemical binding]; other site
281310004950	homotetramer interface [polypeptide binding]; other site
281310004951	homodimer interface [polypeptide binding]; other site
281310004952	active site
281310004953	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
281310004954	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
281310004955	dimerization interface [polypeptide binding]; other site
281310004956	putative ATP binding site [chemical binding]; other site
281310004957	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
281310004958	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
281310004959	active site
281310004960	substrate binding site [chemical binding]; other site
281310004961	cosubstrate binding site; other site
281310004962	catalytic site [active]
281310004963	ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
281310004964	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
281310004965	universal stress protein UspE; Provisional; Region: PRK11175
281310004966	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
281310004967	Ligand Binding Site [chemical binding]; other site
281310004968	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
281310004969	Ligand Binding Site [chemical binding]; other site
281310004970	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
281310004971	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
281310004972	ligand binding site [chemical binding]; other site
281310004973	flexible hinge region; other site
281310004974	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
281310004975	putative switch regulator; other site
281310004976	non-specific DNA interactions [nucleotide binding]; other site
281310004977	DNA binding site [nucleotide binding]
281310004978	sequence specific DNA binding site [nucleotide binding]; other site
281310004979	putative cAMP binding site [chemical binding]; other site
281310004980	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
281310004981	DNA binding site [nucleotide binding]
281310004982	active site
281310004983	Int/Topo IB signature motif; other site
281310004984	AntA/AntB antirepressor; Region: AntA; pfam08346
281310004985	Domain of unknown function (DUF4325); Region: DUF4325; pfam14213
281310004986	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
281310004987	non-specific DNA binding site [nucleotide binding]; other site
281310004988	salt bridge; other site
281310004989	sequence-specific DNA binding site [nucleotide binding]; other site
281310004990	Predicted transcriptional regulator [Transcription]; Region: COG2932
281310004991	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
281310004992	Catalytic site [active]
281310004993	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
281310004994	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
281310004995	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
281310004996	Helix-turn-helix domain; Region: HTH_36; pfam13730
281310004997	Replication protein P; Region: Phage_lambda_P; pfam06992
281310004998	NinB protein; Region: NinB; pfam05772
281310004999	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
281310005000	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
281310005001	active site
281310005002	Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530
281310005003	P63C domain; Region: P63C; pfam10546
281310005004	Prophage antirepressor [Transcription]; Region: COG3617
281310005005	BRO family, N-terminal domain; Region: Bro-N; pfam02498
281310005006	P22AR C-terminal domain; Region: P22_AR_C; pfam10548
281310005007	phage holin, lambda family; Region: holin_lambda; TIGR01594
281310005008	Predicted chitinase [General function prediction only]; Region: COG3179
281310005009	catalytic residue [active]
281310005010	Protein of unknown function (DUF2570); Region: DUF2570; pfam10828
281310005011	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
281310005012	non-specific DNA binding site [nucleotide binding]; other site
281310005013	salt bridge; other site
281310005014	sequence-specific DNA binding site [nucleotide binding]; other site
281310005015	Terminase small subunit; Region: Terminase_2; pfam03592
281310005016	Phage terminase large subunit; Region: Terminase_3; cl12054
281310005017	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567
281310005018	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
281310005019	Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369
281310005020	Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233
281310005021	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
281310005022	dihydroorotate dehydrogenase, subfamily 2; Region: pyrD_sub2; TIGR01036
281310005023	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
281310005024	quinone interaction residues [chemical binding]; other site
281310005025	active site
281310005026	catalytic residues [active]
281310005027	FMN binding site [chemical binding]; other site
281310005028	substrate binding site [chemical binding]; other site
281310005029	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
281310005030	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
281310005031	active site
281310005032	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
281310005033	fumarate hydratase; Reviewed; Region: fumC; PRK00485
281310005034	Class II fumarases; Region: Fumarase_classII; cd01362
281310005035	active site
281310005036	tetramer interface [polypeptide binding]; other site
281310005037	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
281310005038	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
281310005039	Ligand binding site; other site
281310005040	metal-binding site
281310005041	NTHIp1751A; similar to: usg protein homolog, N-terminal fragment
281310005042	NTHIp1751B; similar to: usg protein homolog, C-terminal fragment
281310005043	DNA polymerase III subunit chi; Validated; Region: PRK05728
281310005044	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
281310005045	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
281310005046	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
281310005047	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
281310005048	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
281310005049	HIGH motif; other site
281310005050	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
281310005051	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
281310005052	active site
281310005053	KMSKS motif; other site
281310005054	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
281310005055	tRNA binding surface [nucleotide binding]; other site
281310005056	anticodon binding site; other site
281310005057	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
281310005058	HupF/HypC family; Region: HupF_HypC; cl00394
281310005059	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
281310005060	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
281310005061	active site
281310005062	ribulose/triose binding site [chemical binding]; other site
281310005063	phosphate binding site [ion binding]; other site
281310005064	substrate (anthranilate) binding pocket [chemical binding]; other site
281310005065	product (indole) binding pocket [chemical binding]; other site
281310005066	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
281310005067	active site
281310005068	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
281310005069	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
281310005070	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
281310005071	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
281310005072	Glutamine amidotransferase class-I; Region: GATase; pfam00117
281310005073	glutamine binding [chemical binding]; other site
281310005074	catalytic triad [active]
281310005075	anthranilate synthase component I; Provisional; Region: PRK13564
281310005076	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
281310005077	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
281310005078	NTHIp1769B; similar to: conserved hypothetical glycosyltransferase, C-terminal fragment
281310005079	NTHIp1769A; similar to: conserved hypothetical glycosyltransferase, N-terminal fragment
281310005080	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
281310005081	Ferritin-like domain; Region: Ferritin; pfam00210
281310005082	ferroxidase diiron center [ion binding]; other site
281310005083	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
281310005084	Ferritin-like domain; Region: Ferritin; pfam00210
281310005085	ferroxidase diiron center [ion binding]; other site
281310005086	PBP superfamily domain; Region: PBP_like_2; cl17296
281310005087	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
281310005088	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310005089	dimer interface [polypeptide binding]; other site
281310005090	conserved gate region; other site
281310005091	putative PBP binding loops; other site
281310005092	ABC-ATPase subunit interface; other site
281310005093	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
281310005094	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310005095	dimer interface [polypeptide binding]; other site
281310005096	conserved gate region; other site
281310005097	putative PBP binding loops; other site
281310005098	ABC-ATPase subunit interface; other site
281310005099	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
281310005100	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
281310005101	Walker A/P-loop; other site
281310005102	ATP binding site [chemical binding]; other site
281310005103	Q-loop/lid; other site
281310005104	ABC transporter signature motif; other site
281310005105	Walker B; other site
281310005106	D-loop; other site
281310005107	H-loop/switch region; other site
281310005108	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
281310005109	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
281310005110	active site
281310005111	phosphorylation site [posttranslational modification]
281310005112	intermolecular recognition site; other site
281310005113	dimerization interface [polypeptide binding]; other site
281310005114	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
281310005115	DNA binding site [nucleotide binding]
281310005116	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
281310005117	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
281310005118	putative active site [active]
281310005119	heme pocket [chemical binding]; other site
281310005120	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
281310005121	dimer interface [polypeptide binding]; other site
281310005122	phosphorylation site [posttranslational modification]
281310005123	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
281310005124	ATP binding site [chemical binding]; other site
281310005125	Mg2+ binding site [ion binding]; other site
281310005126	G-X-G motif; other site
281310005127	exonuclease I; Provisional; Region: sbcB; PRK11779
281310005128	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
281310005129	active site
281310005130	catalytic site [active]
281310005131	substrate binding site [chemical binding]; other site
281310005132	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
281310005133	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
281310005134	Uncharacterized conserved protein [Function unknown]; Region: COG3586
281310005135	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
281310005136	P-loop containing region of AAA domain; Region: AAA_29; cl17516
281310005137	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
281310005138	condesin subunit E; Provisional; Region: PRK05256
281310005139	HaeII restriction endonuclease; Region: RE_HaeII; pfam09554
281310005140	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
281310005141	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
281310005142	cofactor binding site; other site
281310005143	DNA binding site [nucleotide binding]
281310005144	substrate interaction site [chemical binding]; other site
281310005145	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukF; COG3006
281310005146	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
281310005147	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
281310005148	Ligand Binding Site [chemical binding]; other site
281310005149	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
281310005150	DsrC like protein; Region: DsrC; pfam04358
281310005151	molybdenum-pterin binding domain; Region: Mop; TIGR00638
281310005152	NTHIp1794A; similar to: conserved hypothetical protein, N-terminal fragment
281310005153	NTHIp1794B; similar to: conserved hypothetical protein, central fragment
281310005154	NTHIp1794C; similar to: conserved hypothetical protein, C-terminal fragment
281310005155	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
281310005156	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
281310005157	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
281310005158	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
281310005159	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
281310005160	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
281310005161	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
281310005162	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
281310005163	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
281310005164	active site
281310005165	dimer interface [polypeptide binding]; other site
281310005166	motif 1; other site
281310005167	motif 2; other site
281310005168	motif 3; other site
281310005169	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
281310005170	anticodon binding site; other site
281310005171	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
281310005172	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
281310005173	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
281310005174	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
281310005175	active site
281310005176	interdomain interaction site; other site
281310005177	putative metal-binding site [ion binding]; other site
281310005178	nucleotide binding site [chemical binding]; other site
281310005179	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
281310005180	domain I; other site
281310005181	DNA binding groove [nucleotide binding]
281310005182	phosphate binding site [ion binding]; other site
281310005183	domain II; other site
281310005184	domain III; other site
281310005185	nucleotide binding site [chemical binding]; other site
281310005186	catalytic site [active]
281310005187	domain IV; other site
281310005188	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
281310005189	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
281310005190	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
281310005191	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
281310005192	Transcriptional regulator [Transcription]; Region: LysR; COG0583
281310005193	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
281310005194	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
281310005195	putative effector binding pocket; other site
281310005196	dimerization interface [polypeptide binding]; other site
281310005197	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
281310005198	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
281310005199	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
281310005200	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
281310005201	ligand binding site [chemical binding]; other site
281310005202	homodimer interface [polypeptide binding]; other site
281310005203	NAD(P) binding site [chemical binding]; other site
281310005204	trimer interface B [polypeptide binding]; other site
281310005205	trimer interface A [polypeptide binding]; other site
281310005206	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
281310005207	glycogen phosphorylase; Provisional; Region: PRK14986
281310005208	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
281310005209	homodimer interface [polypeptide binding]; other site
281310005210	active site pocket [active]
281310005211	glycogen synthase; Provisional; Region: glgA; PRK00654
281310005212	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
281310005213	ADP-binding pocket [chemical binding]; other site
281310005214	homodimer interface [polypeptide binding]; other site
281310005215	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
281310005216	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
281310005217	ligand binding site; other site
281310005218	oligomer interface; other site
281310005219	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
281310005220	dimer interface [polypeptide binding]; other site
281310005221	N-terminal domain interface [polypeptide binding]; other site
281310005222	sulfate 1 binding site; other site
281310005223	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
281310005224	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
281310005225	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
281310005226	active site
281310005227	catalytic site [active]
281310005228	glycogen branching enzyme; Provisional; Region: PRK05402
281310005229	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
281310005230	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
281310005231	active site
281310005232	catalytic site [active]
281310005233	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
281310005234	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
281310005235	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
281310005236	Uncharacterized conserved protein [Function unknown]; Region: COG2983
281310005237	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
281310005238	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
281310005239	active site
281310005240	HIGH motif; other site
281310005241	nucleotide binding site [chemical binding]; other site
281310005242	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
281310005243	KMSKS motif; other site
281310005244	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
281310005245	ribonuclease G; Provisional; Region: PRK11712
281310005246	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
281310005247	homodimer interface [polypeptide binding]; other site
281310005248	oligonucleotide binding site [chemical binding]; other site
281310005249	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
281310005250	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
281310005251	Na binding site [ion binding]; other site
281310005252	Methyltransferase domain; Region: Methyltransf_23; pfam13489
281310005253	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
281310005254	S-adenosylmethionine binding site [chemical binding]; other site
281310005255	cytidine deaminase; Provisional; Region: PRK09027
281310005256	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
281310005257	active site
281310005258	catalytic motif [active]
281310005259	Zn binding site [ion binding]; other site
281310005260	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
281310005261	active site
281310005262	catalytic motif [active]
281310005263	Zn binding site [ion binding]; other site
281310005264	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
281310005265	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
281310005266	dimerization interface [polypeptide binding]; other site
281310005267	DPS ferroxidase diiron center [ion binding]; other site
281310005268	ion pore; other site
281310005269	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
281310005270	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
281310005271	metal binding site [ion binding]; metal-binding site
281310005272	dimer interface [polypeptide binding]; other site
281310005273	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
281310005274	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
281310005275	Walker A/P-loop; other site
281310005276	ATP binding site [chemical binding]; other site
281310005277	Q-loop/lid; other site
281310005278	ABC transporter signature motif; other site
281310005279	Walker B; other site
281310005280	D-loop; other site
281310005281	H-loop/switch region; other site
281310005282	TOBE domain; Region: TOBE_2; pfam08402
281310005283	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
281310005284	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310005285	dimer interface [polypeptide binding]; other site
281310005286	conserved gate region; other site
281310005287	putative PBP binding loops; other site
281310005288	ABC-ATPase subunit interface; other site
281310005289	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
281310005290	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310005291	dimer interface [polypeptide binding]; other site
281310005292	conserved gate region; other site
281310005293	ABC-ATPase subunit interface; other site
281310005294	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
281310005295	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
281310005296	ABC transporter ATPase component; Reviewed; Region: PRK11147
281310005297	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
281310005298	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
281310005299	ABC transporter; Region: ABC_tran_2; pfam12848
281310005300	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
281310005301	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
281310005302	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
281310005303	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
281310005304	TIGR00659 family protein; Region: TIGR00659
281310005305	hypothetical protein; Provisional; Region: PRK01821
281310005306	Staphylococcal nuclease homologues; Region: SNc; smart00318
281310005307	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
281310005308	Catalytic site; other site
281310005309	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
281310005310	Aminotransferase class-V; Region: Aminotran_5; pfam00266
281310005311	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
281310005312	catalytic residue [active]
281310005313	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
281310005314	Zn-ribbon-containing, possibly nucleic-acid-binding protein [General function prediction only]; Region: COG5595
281310005315	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
281310005316	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
281310005317	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
281310005318	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
281310005319	chorismate mutase domain of T-protein; Region: CM_T; TIGR01799
281310005320	prephenate dehydrogenase; Validated; Region: PRK08507
281310005321	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
281310005322	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
281310005323	RNA binding site [nucleotide binding]; other site
281310005324	active site
281310005325	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
281310005326	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
281310005327	HsdM N-terminal domain; Region: HsdM_N; pfam12161
281310005328	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
281310005329	Methyltransferase domain; Region: Methyltransf_26; pfam13659
281310005330	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
281310005331	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
281310005332	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
281310005333	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
281310005334	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
281310005335	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
281310005336	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
281310005337	ATP binding site [chemical binding]; other site
281310005338	putative Mg++ binding site [ion binding]; other site
281310005339	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
281310005340	translation initiation factor IF-2; Region: IF-2; TIGR00487
281310005341	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
281310005342	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
281310005343	G1 box; other site
281310005344	putative GEF interaction site [polypeptide binding]; other site
281310005345	GTP/Mg2+ binding site [chemical binding]; other site
281310005346	Switch I region; other site
281310005347	G2 box; other site
281310005348	G3 box; other site
281310005349	Switch II region; other site
281310005350	G4 box; other site
281310005351	G5 box; other site
281310005352	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
281310005353	Translation-initiation factor 2; Region: IF-2; pfam11987
281310005354	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
281310005355	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
281310005356	NusA N-terminal domain; Region: NusA_N; pfam08529
281310005357	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
281310005358	RNA binding site [nucleotide binding]; other site
281310005359	homodimer interface [polypeptide binding]; other site
281310005360	NusA-like KH domain; Region: KH_5; pfam13184
281310005361	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
281310005362	G-X-X-G motif; other site
281310005363	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
281310005364	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
281310005365	ribosome maturation protein RimP; Reviewed; Region: PRK00092
281310005366	Sm and related proteins; Region: Sm_like; cl00259
281310005367	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
281310005368	putative oligomer interface [polypeptide binding]; other site
281310005369	putative RNA binding site [nucleotide binding]; other site
281310005370	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
281310005371	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
281310005372	Phage Tail Collar Domain; Region: Collar; pfam07484
281310005373	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
281310005374	baseplate assembly protein; Provisional; Region: J; PHA02568
281310005375	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
281310005376	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
281310005377	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
281310005378	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
281310005379	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
281310005380	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
281310005381	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
281310005382	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
281310005383	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
281310005384	DksA-like zinc finger domain containing protein; Region: PHA00080
281310005385	phage lambda Rz1-like protein; Region: PHA02047
281310005386	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
281310005387	catalytic residues [active]
281310005388	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
281310005389	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
281310005390	terminase endonuclease subunit; Provisional; Region: M; PHA02537
281310005391	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
281310005392	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
281310005393	capsid-scaffolding protein; Provisional; Region: O; PHA02529
281310005394	terminase ATPase subunit; Provisional; Region: P; PHA02535
281310005395	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
281310005396	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
281310005397	portal vertex protein; Provisional; Region: Q; PHA02536
281310005398	Phage portal protein; Region: Phage_portal; pfam04860
281310005399	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
281310005400	ligand binding site; other site
281310005401	tetramer interface; other site
281310005402	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
281310005403	dimer interface [polypeptide binding]; other site
281310005404	FMN binding site [chemical binding]; other site
281310005405	antiporter inner membrane protein; Provisional; Region: PRK11670
281310005406	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
281310005407	Walker A motif; other site
281310005408	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
281310005409	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
281310005410	active site
281310005411	HIGH motif; other site
281310005412	KMSKS motif; other site
281310005413	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
281310005414	tRNA binding surface [nucleotide binding]; other site
281310005415	anticodon binding site; other site
281310005416	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
281310005417	dimer interface [polypeptide binding]; other site
281310005418	putative tRNA-binding site [nucleotide binding]; other site
281310005419	tellurite resistance protein TehB; Provisional; Region: PRK12335
281310005420	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
281310005421	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
281310005422	S-adenosylmethionine binding site [chemical binding]; other site
281310005423	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
281310005424	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
281310005425	S-adenosylmethionine binding site [chemical binding]; other site
281310005426	uncharacterized domain; Region: TIGR00702
281310005427	YcaO-like family; Region: YcaO; pfam02624
281310005428	DNA gyrase subunit A; Validated; Region: PRK05560
281310005429	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
281310005430	CAP-like domain; other site
281310005431	active site
281310005432	primary dimer interface [polypeptide binding]; other site
281310005433	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
281310005434	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
281310005435	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
281310005436	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
281310005437	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
281310005438	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
281310005439	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
281310005440	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
281310005441	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
281310005442	putative active site [active]
281310005443	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
281310005444	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
281310005445	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
281310005446	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
281310005447	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
281310005448	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
281310005449	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
281310005450	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
281310005451	protein binding site [polypeptide binding]; other site
281310005452	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
281310005453	transcription-repair coupling factor; Provisional; Region: PRK10689
281310005454	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
281310005455	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
281310005456	ATP binding site [chemical binding]; other site
281310005457	putative Mg++ binding site [ion binding]; other site
281310005458	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
281310005459	nucleotide binding region [chemical binding]; other site
281310005460	ATP-binding site [chemical binding]; other site
281310005461	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
281310005462	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
281310005463	Domain of unknown function (DUF1726); Region: DUF1726; pfam08351
281310005464	Helicase; Region: Helicase_RecD; pfam05127
281310005465	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
281310005466	Coenzyme A binding pocket [chemical binding]; other site
281310005467	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
281310005468	Invasion gene expression up-regulator, SirB; Region: SirB; cl01184
281310005469	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
281310005470	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
281310005471	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
281310005472	ABC transporter; Region: ABC_tran_2; pfam12848
281310005473	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
281310005474	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
281310005475	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
281310005476	non-specific DNA binding site [nucleotide binding]; other site
281310005477	salt bridge; other site
281310005478	sequence-specific DNA binding site [nucleotide binding]; other site
281310005479	Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549
281310005480	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
281310005481	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
281310005482	excinuclease ABC subunit B; Provisional; Region: PRK05298
281310005483	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
281310005484	ATP binding site [chemical binding]; other site
281310005485	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
281310005486	nucleotide binding region [chemical binding]; other site
281310005487	ATP-binding site [chemical binding]; other site
281310005488	Ultra-violet resistance protein B; Region: UvrB; pfam12344
281310005489	UvrB/uvrC motif; Region: UVR; pfam02151
281310005490	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
281310005491	Sulfatase; Region: Sulfatase; pfam00884
281310005492	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
281310005493	Malic enzyme, N-terminal domain; Region: malic; pfam00390
281310005494	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
281310005495	putative NAD(P) binding site [chemical binding]; other site
281310005496	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
281310005497	Exopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3955
281310005498	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
281310005499	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
281310005500	RNA binding surface [nucleotide binding]; other site
281310005501	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
281310005502	active site
281310005503	uracil binding [chemical binding]; other site
281310005504	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
281310005505	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
281310005506	putative substrate translocation pore; other site
281310005507	Predicted membrane protein [Function unknown]; Region: COG2860
281310005508	UPF0126 domain; Region: UPF0126; pfam03458
281310005509	UPF0126 domain; Region: UPF0126; pfam03458
281310005510	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
281310005511	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
281310005512	putative catalytic cysteine [active]
281310005513	chaperone protein DnaJ; Provisional; Region: PRK10767
281310005514	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
281310005515	HSP70 interaction site [polypeptide binding]; other site
281310005516	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
281310005517	substrate binding site [polypeptide binding]; other site
281310005518	dimer interface [polypeptide binding]; other site
281310005519	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
281310005520	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
281310005521	nucleotide binding site [chemical binding]; other site
281310005522	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
281310005523	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
281310005524	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
281310005525	active site
281310005526	dimer interfaces [polypeptide binding]; other site
281310005527	catalytic residues [active]
281310005528	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
281310005529	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
281310005530	dimer interface [polypeptide binding]; other site
281310005531	TPP-binding site [chemical binding]; other site
281310005532	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
281310005533	E3 interaction surface; other site
281310005534	lipoyl attachment site [posttranslational modification]; other site
281310005535	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508
281310005536	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
281310005537	E3 interaction surface; other site
281310005538	lipoyl attachment site [posttranslational modification]; other site
281310005539	e3 binding domain; Region: E3_binding; pfam02817
281310005540	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
281310005541	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
281310005542	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
281310005543	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
281310005544	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
281310005545	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
281310005546	active site
281310005547	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
281310005548	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
281310005549	Walker A motif; other site
281310005550	ATP binding site [chemical binding]; other site
281310005551	Walker B motif; other site
281310005552	DNA polymerase III subunit delta'; Validated; Region: PRK08485
281310005553	arginine finger; other site
281310005554	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
281310005555	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
281310005556	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
281310005557	active site
281310005558	uracil-xanthine permease; Region: ncs2; TIGR00801
281310005559	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
281310005560	DNA replication initiation factor; Validated; Region: PRK06893
281310005561	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
281310005562	putative rRNA binding site [nucleotide binding]; other site
281310005563	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
281310005564	active site
281310005565	dimer interface [polypeptide binding]; other site
281310005566	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
281310005567	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
281310005568	binding surface
281310005569	TPR motif; other site
281310005570	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
281310005571	Predicted membrane protein [Function unknown]; Region: COG3771
281310005572	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
281310005573	IHF dimer interface [polypeptide binding]; other site
281310005574	IHF - DNA interface [nucleotide binding]; other site
281310005575	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
281310005576	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
281310005577	RNA binding site [nucleotide binding]; other site
281310005578	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
281310005579	RNA binding site [nucleotide binding]; other site
281310005580	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
281310005581	RNA binding site [nucleotide binding]; other site
281310005582	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
281310005583	RNA binding site [nucleotide binding]; other site
281310005584	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
281310005585	RNA binding site [nucleotide binding]; other site
281310005586	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
281310005587	RNA binding site [nucleotide binding]; other site
281310005588	cytidylate kinase; Provisional; Region: cmk; PRK00023
281310005589	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
281310005590	CMP-binding site; other site
281310005591	The sites determining sugar specificity; other site
281310005592	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
281310005593	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
281310005594	active site
281310005595	multimer interface [polypeptide binding]; other site
281310005596	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
281310005597	predicted active site [active]
281310005598	catalytic triad [active]
281310005599	D-lactate dehydrogenase; Provisional; Region: PRK11183
281310005600	FAD binding domain; Region: FAD_binding_4; pfam01565
281310005601	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
281310005602	Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
281310005603	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
281310005604	NlpC/P60 family; Region: NLPC_P60; pfam00877
281310005605	protease TldD; Provisional; Region: tldD; PRK10735
281310005606	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
281310005607	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
281310005608	putative SAM binding site [chemical binding]; other site
281310005609	putative homodimer interface [polypeptide binding]; other site
281310005610	LppC putative lipoprotein; Region: LppC; pfam04348
281310005611	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
281310005612	putative ligand binding site [chemical binding]; other site
281310005613	TIGR00252 family protein; Region: TIGR00252
281310005614	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
281310005615	dimer interface [polypeptide binding]; other site
281310005616	active site
281310005617	outer membrane lipoprotein; Provisional; Region: PRK11023
281310005618	BON domain; Region: BON; pfam04972
281310005619	BON domain; Region: BON; cl02771
281310005620	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
281310005621	ATP cone domain; Region: ATP-cone; pfam03477
281310005622	Class I ribonucleotide reductase; Region: RNR_I; cd01679
281310005623	active site
281310005624	dimer interface [polypeptide binding]; other site
281310005625	catalytic residues [active]
281310005626	effector binding site; other site
281310005627	R2 peptide binding site; other site
281310005628	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
281310005629	dimer interface [polypeptide binding]; other site
281310005630	putative radical transfer pathway; other site
281310005631	diiron center [ion binding]; other site
281310005632	tyrosyl radical; other site
281310005633	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
281310005634	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
281310005635	E3 interaction surface; other site
281310005636	lipoyl attachment site [posttranslational modification]; other site
281310005637	e3 binding domain; Region: E3_binding; pfam02817
281310005638	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
281310005639	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
281310005640	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
281310005641	TPP-binding site [chemical binding]; other site
281310005642	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
281310005643	PYR/PP interface [polypeptide binding]; other site
281310005644	dimer interface [polypeptide binding]; other site
281310005645	TPP binding site [chemical binding]; other site
281310005646	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
281310005647	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
281310005648	active site
281310005649	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
281310005650	Peptidase M15; Region: Peptidase_M15_3; cl01194
281310005651	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
281310005652	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
281310005653	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
281310005654	carboxy-terminal protease; Provisional; Region: PRK11186
281310005655	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
281310005656	protein binding site [polypeptide binding]; other site
281310005657	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
281310005658	Catalytic dyad [active]
281310005659	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
281310005660	ProP expression regulator; Provisional; Region: PRK04950
281310005661	ProQ/FINO family; Region: ProQ; smart00945
281310005662	KOW motif; Region: KOW; pfam00467
281310005663	integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155
281310005664	Paraquat-inducible protein A; Region: PqiA; pfam04403
281310005665	Paraquat-inducible protein A; Region: PqiA; pfam04403
281310005666	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
281310005667	mce related protein; Region: MCE; pfam02470
281310005668	mce related protein; Region: MCE; pfam02470
281310005669	mce related protein; Region: MCE; pfam02470
281310005670	mce related protein; Region: MCE; pfam02470
281310005671	mce related protein; Region: MCE; pfam02470
281310005672	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
281310005673	MoaE homodimer interface [polypeptide binding]; other site
281310005674	MoaD interaction [polypeptide binding]; other site
281310005675	active site residues [active]
281310005676	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
281310005677	MoaE interaction surface [polypeptide binding]; other site
281310005678	MoeB interaction surface [polypeptide binding]; other site
281310005679	thiocarboxylated glycine; other site
281310005680	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
281310005681	trimer interface [polypeptide binding]; other site
281310005682	dimer interface [polypeptide binding]; other site
281310005683	putative active site [active]
281310005684	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
281310005685	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
281310005686	FeS/SAM binding site; other site
281310005687	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
281310005688	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
281310005689	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
281310005690	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
281310005691	KpsF/GutQ family protein; Region: kpsF; TIGR00393
281310005692	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
281310005693	putative active site [active]
281310005694	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
281310005695	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
281310005696	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
281310005697	active site
281310005698	motif I; other site
281310005699	motif II; other site
281310005700	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
281310005701	haemagglutination activity domain; Region: Haemagg_act; pfam05860
281310005702	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
281310005703	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
281310005704	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
281310005705	TIGR01666 family membrane protein; Region: YCCS
281310005706	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
281310005707	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
281310005708	hypothetical protein; Provisional; Region: PRK01904
281310005709	hypothetical protein; Provisional; Region: PRK03641
281310005710	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
281310005711	putative inner membrane peptidase; Provisional; Region: PRK11778
281310005712	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
281310005713	tandem repeat interface [polypeptide binding]; other site
281310005714	oligomer interface [polypeptide binding]; other site
281310005715	active site residues [active]
281310005716	electron transport complex protein RsxA; Provisional; Region: PRK05151
281310005717	electron transport complex protein RnfB; Provisional; Region: PRK05113
281310005718	Putative Fe-S cluster; Region: FeS; pfam04060
281310005719	4Fe-4S binding domain; Region: Fer4; pfam00037
281310005720	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
281310005721	SLBB domain; Region: SLBB; pfam10531
281310005722	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
281310005723	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
281310005724	electron transport complex protein RnfG; Validated; Region: PRK01908
281310005725	electron transport complex RsxE subunit; Provisional; Region: PRK12405
281310005726	endonuclease III; Provisional; Region: PRK10702
281310005727	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
281310005728	minor groove reading motif; other site
281310005729	helix-hairpin-helix signature motif; other site
281310005730	substrate binding pocket [chemical binding]; other site
281310005731	active site
281310005732	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
281310005733	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
281310005734	Na2 binding site [ion binding]; other site
281310005735	putative substrate binding site 1 [chemical binding]; other site
281310005736	Na binding site 1 [ion binding]; other site
281310005737	putative substrate binding site 2 [chemical binding]; other site
281310005738	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
281310005739	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
281310005740	Walker A/P-loop; other site
281310005741	ATP binding site [chemical binding]; other site
281310005742	Q-loop/lid; other site
281310005743	ABC transporter signature motif; other site
281310005744	Walker B; other site
281310005745	D-loop; other site
281310005746	H-loop/switch region; other site
281310005747	molybdenum-pterin binding domain; Region: Mop; TIGR00638
281310005748	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
281310005749	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
281310005750	dimer interface [polypeptide binding]; other site
281310005751	conserved gate region; other site
281310005752	putative PBP binding loops; other site
281310005753	ABC-ATPase subunit interface; other site
281310005754	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
281310005755	molybdenum ABC transporter, periplasmic molybdate-binding protein; Region: modA; TIGR01256
281310005756	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
281310005757	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
281310005758	molybdenum-pterin binding domain; Region: Mop; TIGR00638
281310005759	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
281310005760	GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195
281310005761	colanic acid biosynthesis glycosyl transferase WcaA; Region: WcaA; TIGR04017
281310005762	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
281310005763	active site
281310005764	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
281310005765	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298
281310005766	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
281310005767	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
281310005768	putative ADP-binding pocket [chemical binding]; other site
281310005769	Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922
281310005770	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
281310005771	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
281310005772	Uncharacterized conserved protein [Function unknown]; Region: COG1434
281310005773	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
281310005774	putative active site [active]
281310005775	NTHIp2009B; similar to: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, C-terminal fragment
281310005776	NTHIp2009A; similar to: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, N-terminal fragment
281310005777	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
281310005778	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
281310005779	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
281310005780	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
281310005781	multifunctional aminopeptidase A; Provisional; Region: PRK00913
281310005782	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
281310005783	interface (dimer of trimers) [polypeptide binding]; other site
281310005784	Substrate-binding/catalytic site; other site
281310005785	Zn-binding sites [ion binding]; other site
281310005786	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
281310005787	sensor protein QseC; Provisional; Region: PRK10337
281310005788	HAMP domain; Region: HAMP; pfam00672
281310005789	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
281310005790	dimer interface [polypeptide binding]; other site
281310005791	phosphorylation site [posttranslational modification]
281310005792	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
281310005793	ATP binding site [chemical binding]; other site
281310005794	Mg2+ binding site [ion binding]; other site
281310005795	G-X-G motif; other site
281310005796	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
281310005797	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
281310005798	active site
281310005799	phosphorylation site [posttranslational modification]
281310005800	intermolecular recognition site; other site
281310005801	dimerization interface [polypeptide binding]; other site
281310005802	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
281310005803	DNA binding site [nucleotide binding]
281310005804	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
281310005805	NTHIp2018B; similar to: mannose-6-phosphate isomerase, C-terminal fragment
281310005806	NTHIp2018A; similar to: mannose-6-phosphate isomerase, N-terminal fragment
281310005807	PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439
281310005808	HPr interaction site; other site
281310005809	glycerol kinase (GK) interaction site [polypeptide binding]; other site
281310005810	active site
281310005811	phosphorylation site [posttranslational modification]
281310005812	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
281310005813	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
281310005814	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
281310005815	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
281310005816	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
281310005817	dimerization domain swap beta strand [polypeptide binding]; other site
281310005818	regulatory protein interface [polypeptide binding]; other site
281310005819	active site
281310005820	regulatory phosphorylation site [posttranslational modification]; other site
281310005821	GTPase RsgA; Reviewed; Region: PRK12288
281310005822	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
281310005823	RNA binding site [nucleotide binding]; other site
281310005824	homodimer interface [polypeptide binding]; other site
281310005825	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
281310005826	GTPase/Zn-binding domain interface [polypeptide binding]; other site
281310005827	GTP/Mg2+ binding site [chemical binding]; other site
281310005828	G4 box; other site
281310005829	G5 box; other site
281310005830	G1 box; other site
281310005831	Switch I region; other site
281310005832	G2 box; other site
281310005833	G3 box; other site
281310005834	Switch II region; other site
281310005835	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
281310005836	catalytic site [active]
281310005837	putative active site [active]
281310005838	putative substrate binding site [chemical binding]; other site
281310005839	dimer interface [polypeptide binding]; other site
281310005840	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
281310005841	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
281310005842	Mg++ binding site [ion binding]; other site
281310005843	putative catalytic motif [active]
281310005844	substrate binding site [chemical binding]; other site
281310005845	PII uridylyl-transferase; Provisional; Region: glnD; PRK01759
281310005846	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
281310005847	metal binding triad; other site
281310005848	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
281310005849	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
281310005850	Zn2+ binding site [ion binding]; other site
281310005851	Mg2+ binding site [ion binding]; other site
281310005852	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
281310005853	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
281310005854	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
281310005855	active site
281310005856	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
281310005857	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3112
281310005858	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
281310005859	Transglycosylase; Region: Transgly; pfam00912
281310005860	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
281310005861	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
281310005862	ATP binding site [chemical binding]; other site
281310005863	active site
281310005864	substrate binding site [chemical binding]; other site
281310005865	argininosuccinate synthase; Provisional; Region: PRK13820
281310005866	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
281310005867	ANP binding site [chemical binding]; other site
281310005868	Substrate Binding Site II [chemical binding]; other site
281310005869	Substrate Binding Site I [chemical binding]; other site
281310005870	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
281310005871	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
281310005872	putative active site [active]
281310005873	biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724
281310005874	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
281310005875	sensor histidine kinase inhibitor, KipI family; Region: TIGR00370
281310005876	exoribonuclease II; Provisional; Region: PRK05054
281310005877	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
281310005878	RNB domain; Region: RNB; pfam00773
281310005879	S1 RNA binding domain; Region: S1; pfam00575
281310005880	RNA binding site [nucleotide binding]; other site
281310005881	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
281310005882	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
281310005883	NAD binding site [chemical binding]; other site
281310005884	homotetramer interface [polypeptide binding]; other site
281310005885	homodimer interface [polypeptide binding]; other site
281310005886	substrate binding site [chemical binding]; other site
281310005887	active site
281310005888	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
281310005889	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
281310005890	G1 box; other site
281310005891	putative GEF interaction site [polypeptide binding]; other site
281310005892	GTP/Mg2+ binding site [chemical binding]; other site
281310005893	Switch I region; other site
281310005894	G2 box; other site
281310005895	G3 box; other site
281310005896	Switch II region; other site
281310005897	G4 box; other site
281310005898	G5 box; other site
281310005899	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
281310005900	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
281310005901	AzlC protein; Region: AzlC; cl00570
281310005902	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
281310005903	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
281310005904	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
281310005905	putative dimerization interface [polypeptide binding]; other site
281310005906	rRNA operon region 6; NTHIpnote0027
281310005907	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
281310005908	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
281310005909	phosphate binding site [ion binding]; other site
281310005910	Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796
281310005911	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
281310005912	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
281310005913	generic binding surface II; other site
281310005914	ssDNA binding site; other site
281310005915	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
281310005916	ATP binding site [chemical binding]; other site
281310005917	putative Mg++ binding site [ion binding]; other site
281310005918	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
281310005919	nucleotide binding region [chemical binding]; other site
281310005920	ATP-binding site [chemical binding]; other site
281310005921	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
281310005922	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
281310005923	Zn2+ binding site [ion binding]; other site
281310005924	Mg2+ binding site [ion binding]; other site
281310005925	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
281310005926	synthetase active site [active]
281310005927	NTP binding site [chemical binding]; other site
281310005928	metal binding site [ion binding]; metal-binding site
281310005929	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
281310005930	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
281310005931	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
281310005932	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
281310005933	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
281310005934	catalytic site [active]