-- dump date 20140619_103859 -- class Genbank::misc_feature -- table misc_feature_note -- id note 411154000001 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 411154000002 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 411154000003 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 411154000004 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 411154000005 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 411154000006 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 411154000007 putative ligand binding site [chemical binding]; other site 411154000008 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 411154000009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154000010 ATP binding site [chemical binding]; other site 411154000011 Mg2+ binding site [ion binding]; other site 411154000012 G-X-G motif; other site 411154000013 Response regulator receiver domain; Region: Response_reg; pfam00072 411154000014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154000015 active site 411154000016 phosphorylation site [posttranslational modification] 411154000017 intermolecular recognition site; other site 411154000018 dimerization interface [polypeptide binding]; other site 411154000019 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 411154000020 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 411154000021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154000022 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 411154000023 putative substrate translocation pore; other site 411154000024 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 411154000025 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 411154000026 substrate binding [chemical binding]; other site 411154000027 active site 411154000028 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 411154000029 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 411154000030 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154000031 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 411154000032 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 411154000033 starch binding outer membrane protein SusD; Region: SusD; cl17845 411154000034 SusD family; Region: SusD; pfam07980 411154000035 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 411154000036 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 411154000037 putative substrate binding site [chemical binding]; other site 411154000038 putative ATP binding site [chemical binding]; other site 411154000039 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 411154000040 CAAX protease self-immunity; Region: Abi; pfam02517 411154000041 chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242 411154000042 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 411154000043 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 411154000044 DXD motif; other site 411154000045 Tetratricopeptide repeat; Region: TPR_12; pfam13424 411154000046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154000047 TPR motif; other site 411154000048 binding surface 411154000049 Tetratricopeptide repeat; Region: TPR_12; pfam13424 411154000050 Tetratricopeptide repeat; Region: TPR_12; pfam13424 411154000051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 411154000052 binding surface 411154000053 TPR motif; other site 411154000054 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 411154000055 cyclase homology domain; Region: CHD; cd07302 411154000056 nucleotidyl binding site; other site 411154000057 metal binding site [ion binding]; metal-binding site 411154000058 dimer interface [polypeptide binding]; other site 411154000059 Major Facilitator Superfamily; Region: MFS_1; pfam07690 411154000060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154000061 putative substrate translocation pore; other site 411154000062 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 411154000063 conserved repeat domain; Region: B_ant_repeat; TIGR01451 411154000064 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 411154000065 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 411154000066 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 411154000067 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 411154000068 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 411154000069 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 411154000070 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 411154000071 putative DNA binding helix; other site 411154000072 metal binding site 2 [ion binding]; metal-binding site 411154000073 metal binding site 1 [ion binding]; metal-binding site 411154000074 dimer interface [polypeptide binding]; other site 411154000075 structural Zn2+ binding site [ion binding]; other site 411154000076 HlyD family secretion protein; Region: HlyD_2; pfam12700 411154000077 HlyD family secretion protein; Region: HlyD_3; pfam13437 411154000078 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 411154000079 Outer membrane efflux protein; Region: OEP; pfam02321 411154000080 Outer membrane efflux protein; Region: OEP; pfam02321 411154000081 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 411154000082 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 411154000083 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 411154000084 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 411154000085 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 411154000086 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 411154000087 starch binding outer membrane protein SusD; Region: SusD; cd08977 411154000088 SusD family; Region: SusD; pfam07980 411154000089 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 411154000090 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154000091 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154000092 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 411154000093 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 411154000094 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 411154000095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154000096 dimer interface [polypeptide binding]; other site 411154000097 phosphorylation site [posttranslational modification] 411154000098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154000099 ATP binding site [chemical binding]; other site 411154000100 Mg2+ binding site [ion binding]; other site 411154000101 G-X-G motif; other site 411154000102 Response regulator receiver domain; Region: Response_reg; pfam00072 411154000103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154000104 active site 411154000105 phosphorylation site [posttranslational modification] 411154000106 intermolecular recognition site; other site 411154000107 dimerization interface [polypeptide binding]; other site 411154000108 Helix-turn-helix domain; Region: HTH_18; pfam12833 411154000109 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 411154000110 cyclase homology domain; Region: CHD; cd07302 411154000111 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 411154000112 nucleotidyl binding site; other site 411154000113 metal binding site [ion binding]; metal-binding site 411154000114 dimer interface [polypeptide binding]; other site 411154000115 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 411154000116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 411154000117 NAD(P) binding site [chemical binding]; other site 411154000118 active site 411154000119 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 411154000120 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 411154000121 FMN binding site [chemical binding]; other site 411154000122 active site 411154000123 substrate binding site [chemical binding]; other site 411154000124 catalytic residue [active] 411154000125 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 411154000126 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 411154000127 ligand binding site [chemical binding]; other site 411154000128 flexible hinge region; other site 411154000129 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 411154000130 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 411154000131 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 411154000132 putative DNA binding site [nucleotide binding]; other site 411154000133 putative Zn2+ binding site [ion binding]; other site 411154000134 AsnC family; Region: AsnC_trans_reg; pfam01037 411154000135 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248 411154000136 substrate binding site [chemical binding]; other site 411154000137 dimerization interface [polypeptide binding]; other site 411154000138 active site 411154000139 calcium binding site [ion binding]; other site 411154000140 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 411154000141 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 411154000142 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 411154000143 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 411154000144 Mechanosensitive ion channel; Region: MS_channel; pfam00924 411154000145 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 411154000146 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 411154000147 HlyD family secretion protein; Region: HlyD_3; pfam13437 411154000148 Outer membrane efflux protein; Region: OEP; pfam02321 411154000149 Outer membrane efflux protein; Region: OEP; pfam02321 411154000150 Predicted transcriptional regulators [Transcription]; Region: COG1510 411154000151 MarR family; Region: MarR_2; pfam12802 411154000152 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 411154000153 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 411154000154 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 411154000155 Ca2+ binding site [ion binding]; other site 411154000156 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 411154000157 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 411154000158 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 411154000159 Ca2+ binding site [ion binding]; other site 411154000160 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 411154000161 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 411154000162 Ca2+ binding site [ion binding]; other site 411154000163 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 411154000164 Ca2+ binding site [ion binding]; other site 411154000165 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 411154000166 hypothetical protein; Provisional; Region: PRK08201 411154000167 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 411154000168 metal binding site [ion binding]; metal-binding site 411154000169 putative dimer interface [polypeptide binding]; other site 411154000170 Peptidase family M49; Region: Peptidase_M49; pfam03571 411154000171 Transposase; Region: DEDD_Tnp_IS110; pfam01548 411154000172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 411154000173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 411154000174 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 411154000175 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 411154000176 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 411154000177 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 411154000178 PhnA protein; Region: PhnA; pfam03831 411154000179 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 411154000180 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 411154000181 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154000182 Walker A/P-loop; other site 411154000183 ATP binding site [chemical binding]; other site 411154000184 Q-loop/lid; other site 411154000185 ABC transporter signature motif; other site 411154000186 Walker B; other site 411154000187 D-loop; other site 411154000188 H-loop/switch region; other site 411154000189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 411154000190 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 411154000191 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 411154000192 Putative cyclase; Region: Cyclase; pfam04199 411154000193 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 411154000194 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 411154000195 HemN C-terminal domain; Region: HemN_C; pfam06969 411154000196 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 411154000197 active site 411154000198 putative DNA-binding cleft [nucleotide binding]; other site 411154000199 dimer interface [polypeptide binding]; other site 411154000200 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 411154000201 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_e; cd04192 411154000202 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 411154000203 TPR motif; other site 411154000204 binding surface 411154000205 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154000206 binding surface 411154000207 TPR motif; other site 411154000208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154000209 TPR motif; other site 411154000210 binding surface 411154000211 TPR repeat; Region: TPR_11; pfam13414 411154000212 Gram-negative bacterial tonB protein; Region: TonB; cl10048 411154000213 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 411154000214 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 411154000215 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 411154000216 Penicillinase repressor; Region: Pencillinase_R; pfam03965 411154000217 Protein of unknown function (DUF456); Region: DUF456; pfam04306 411154000218 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 411154000219 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 411154000220 YceI-like domain; Region: YceI; pfam04264 411154000221 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 411154000222 iron-sulfur cluster [ion binding]; other site 411154000223 [2Fe-2S] cluster binding site [ion binding]; other site 411154000224 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 411154000225 active site 411154000226 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 411154000227 putative acyl-acceptor binding pocket; other site 411154000228 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 411154000229 active site 411154000230 homodimer interface [polypeptide binding]; other site 411154000231 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 411154000232 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 411154000233 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 411154000234 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 411154000235 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 411154000236 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 411154000237 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 411154000238 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 411154000239 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 411154000240 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 411154000241 RNA binding surface [nucleotide binding]; other site 411154000242 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 411154000243 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 411154000244 active site 411154000245 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 411154000246 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 411154000247 putative dimer interface [polypeptide binding]; other site 411154000248 putative anticodon binding site; other site 411154000249 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 411154000250 homodimer interface [polypeptide binding]; other site 411154000251 motif 1; other site 411154000252 motif 2; other site 411154000253 active site 411154000254 motif 3; other site 411154000255 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 411154000256 Protein export membrane protein; Region: SecD_SecF; cl14618 411154000257 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154000258 ribosome recycling factor; Reviewed; Region: frr; PRK00083 411154000259 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 411154000260 hinge region; other site 411154000261 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 411154000262 putative nucleotide binding site [chemical binding]; other site 411154000263 uridine monophosphate binding site [chemical binding]; other site 411154000264 homohexameric interface [polypeptide binding]; other site 411154000265 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 411154000266 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 411154000267 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 411154000268 putative DNA binding site [nucleotide binding]; other site 411154000269 putative Zn2+ binding site [ion binding]; other site 411154000270 AsnC family; Region: AsnC_trans_reg; pfam01037 411154000271 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 411154000272 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 411154000273 Protein of unknown function (DUF423); Region: DUF423; pfam04241 411154000274 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 411154000275 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 411154000276 active site 411154000277 substrate-binding site [chemical binding]; other site 411154000278 metal-binding site [ion binding] 411154000279 ATP binding site [chemical binding]; other site 411154000280 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 411154000281 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 411154000282 active site 411154000283 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 411154000284 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 411154000285 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 411154000286 Ligand binding site; other site 411154000287 Putative Catalytic site; other site 411154000288 DXD motif; other site 411154000289 dihydroorotase; Reviewed; Region: PRK09236 411154000290 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 411154000291 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 411154000292 active site 411154000293 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 411154000294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 411154000295 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 411154000296 NAD(P) binding site [chemical binding]; other site 411154000297 active site 411154000298 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 411154000299 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 411154000300 active site 411154000301 HIGH motif; other site 411154000302 dimer interface [polypeptide binding]; other site 411154000303 KMSKS motif; other site 411154000304 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 411154000305 RNA binding surface [nucleotide binding]; other site 411154000306 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 411154000307 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 411154000308 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 411154000309 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 411154000310 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154000311 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 411154000312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154000313 active site 411154000314 phosphorylation site [posttranslational modification] 411154000315 intermolecular recognition site; other site 411154000316 dimerization interface [polypeptide binding]; other site 411154000317 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 411154000318 DNA binding site [nucleotide binding] 411154000319 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154000320 dimer interface [polypeptide binding]; other site 411154000321 phosphorylation site [posttranslational modification] 411154000322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154000323 ATP binding site [chemical binding]; other site 411154000324 Mg2+ binding site [ion binding]; other site 411154000325 G-X-G motif; other site 411154000326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154000327 S-adenosylmethionine binding site [chemical binding]; other site 411154000328 LysE type translocator; Region: LysE; cl00565 411154000329 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 411154000330 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 411154000331 DNA binding site [nucleotide binding] 411154000332 active site 411154000333 Domain of unknown function DUF59; Region: DUF59; pfam01883 411154000334 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 411154000335 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 411154000336 Walker A motif; other site 411154000337 NifU-like domain; Region: NifU; cl00484 411154000338 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 411154000339 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 411154000340 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 411154000341 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 411154000342 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 411154000343 catalytic loop [active] 411154000344 iron binding site [ion binding]; other site 411154000345 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 411154000346 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 411154000347 putative hydrophobic ligand binding site [chemical binding]; other site 411154000348 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 411154000349 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 411154000350 active site 411154000351 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 411154000352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154000353 S-adenosylmethionine binding site [chemical binding]; other site 411154000354 elongation factor Ts; Provisional; Region: tsf; PRK09377 411154000355 UBA/TS-N domain; Region: UBA; pfam00627 411154000356 Elongation factor TS; Region: EF_TS; pfam00889 411154000357 Elongation factor TS; Region: EF_TS; pfam00889 411154000358 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 411154000359 rRNA interaction site [nucleotide binding]; other site 411154000360 S8 interaction site; other site 411154000361 putative laminin-1 binding site; other site 411154000362 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 411154000363 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 411154000364 23S rRNA interface [nucleotide binding]; other site 411154000365 L3 interface [polypeptide binding]; other site 411154000366 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 411154000367 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 411154000368 putative ligand binding site [chemical binding]; other site 411154000369 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 411154000370 DNA polymerase I; Provisional; Region: PRK05755 411154000371 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 411154000372 active site 411154000373 metal binding site 1 [ion binding]; metal-binding site 411154000374 putative 5' ssDNA interaction site; other site 411154000375 metal binding site 3; metal-binding site 411154000376 metal binding site 2 [ion binding]; metal-binding site 411154000377 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 411154000378 putative DNA binding site [nucleotide binding]; other site 411154000379 putative metal binding site [ion binding]; other site 411154000380 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 411154000381 active site 411154000382 catalytic site [active] 411154000383 substrate binding site [chemical binding]; other site 411154000384 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 411154000385 active site 411154000386 DNA binding site [nucleotide binding] 411154000387 catalytic site [active] 411154000388 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 411154000389 active site 411154000390 dimer interface [polypeptide binding]; other site 411154000391 catalytic nucleophile [active] 411154000392 phosphodiesterase YaeI; Provisional; Region: PRK11340 411154000393 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 411154000394 putative active site [active] 411154000395 putative metal binding site [ion binding]; other site 411154000396 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 411154000397 catalytic residues [active] 411154000398 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 411154000399 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 411154000400 NodB motif; other site 411154000401 active site 411154000402 catalytic site [active] 411154000403 metal binding site [ion binding]; metal-binding site 411154000404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154000405 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 411154000406 putative substrate translocation pore; other site 411154000407 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 411154000408 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 411154000409 putative NAD(P) binding site [chemical binding]; other site 411154000410 active site 411154000411 putative substrate binding site [chemical binding]; other site 411154000412 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 411154000413 PAS domain S-box; Region: sensory_box; TIGR00229 411154000414 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 411154000415 putative active site [active] 411154000416 heme pocket [chemical binding]; other site 411154000417 PAS domain S-box; Region: sensory_box; TIGR00229 411154000418 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 411154000419 putative active site [active] 411154000420 heme pocket [chemical binding]; other site 411154000421 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 411154000422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154000423 ATP binding site [chemical binding]; other site 411154000424 Mg2+ binding site [ion binding]; other site 411154000425 G-X-G motif; other site 411154000426 Response regulator receiver domain; Region: Response_reg; pfam00072 411154000427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154000428 active site 411154000429 phosphorylation site [posttranslational modification] 411154000430 intermolecular recognition site; other site 411154000431 dimerization interface [polypeptide binding]; other site 411154000432 Homo sapiens 239FB and related proteins, metallophosphatase domain; Region: MPP_239FB; cd07379 411154000433 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 411154000434 putative active site [active] 411154000435 putative metal binding site [ion binding]; other site 411154000436 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 411154000437 Ligand Binding Site [chemical binding]; other site 411154000438 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 411154000439 Ligand Binding Site [chemical binding]; other site 411154000440 hypothetical protein; Validated; Region: PRK02001 411154000441 heptamer interface [polypeptide binding]; other site 411154000442 Sm1 motif; other site 411154000443 hexamer interface [polypeptide binding]; other site 411154000444 RNA binding site [nucleotide binding]; other site 411154000445 Sm2 motif; other site 411154000446 transcription termination factor NusA; Region: NusA; TIGR01953 411154000447 NusA N-terminal domain; Region: NusA_N; pfam08529 411154000448 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 411154000449 RNA binding site [nucleotide binding]; other site 411154000450 homodimer interface [polypeptide binding]; other site 411154000451 NusA-like KH domain; Region: KH_5; pfam13184 411154000452 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 411154000453 G-X-X-G motif; other site 411154000454 translation initiation factor IF-2; Region: IF-2; TIGR00487 411154000455 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 411154000456 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 411154000457 G1 box; other site 411154000458 putative GEF interaction site [polypeptide binding]; other site 411154000459 GTP/Mg2+ binding site [chemical binding]; other site 411154000460 Switch I region; other site 411154000461 G2 box; other site 411154000462 G3 box; other site 411154000463 Switch II region; other site 411154000464 G4 box; other site 411154000465 G5 box; other site 411154000466 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 411154000467 Translation-initiation factor 2; Region: IF-2; pfam11987 411154000468 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 411154000469 Sporulation related domain; Region: SPOR; cl10051 411154000470 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 411154000471 Cytochrome c; Region: Cytochrom_C; pfam00034 411154000472 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 411154000473 heme-binding residues [chemical binding]; other site 411154000474 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 411154000475 molybdopterin cofactor binding site; other site 411154000476 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 411154000477 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 411154000478 4Fe-4S binding domain; Region: Fer4; cl02805 411154000479 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 411154000480 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 411154000481 Uncharacterized conserved protein [Function unknown]; Region: COG3743 411154000482 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 411154000483 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 411154000484 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 411154000485 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 411154000486 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 411154000487 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 411154000488 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 411154000489 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 411154000490 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 411154000491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154000492 Walker A motif; other site 411154000493 ATP binding site [chemical binding]; other site 411154000494 Walker B motif; other site 411154000495 arginine finger; other site 411154000496 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 411154000497 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 411154000498 GIY-YIG motif/motif A; other site 411154000499 putative active site [active] 411154000500 putative metal binding site [ion binding]; other site 411154000501 Cytochrome P450; Region: p450; cl12078 411154000502 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 411154000503 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 411154000504 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 411154000505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 411154000506 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 411154000507 FAD binding domain; Region: FAD_binding_4; pfam01565 411154000508 Berberine and berberine like; Region: BBE; pfam08031 411154000509 NlpE N-terminal domain; Region: NlpE; pfam04170 411154000510 META domain; Region: META; pfam03724 411154000511 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 411154000512 4Fe-4S binding domain; Region: Fer4; pfam00037 411154000513 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 411154000514 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 411154000515 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 411154000516 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 411154000517 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 411154000518 Malic enzyme, N-terminal domain; Region: malic; pfam00390 411154000519 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 411154000520 putative NAD(P) binding site [chemical binding]; other site 411154000521 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 411154000522 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 411154000523 RuvA N terminal domain; Region: RuvA_N; pfam01330 411154000524 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 411154000525 cell surface protein SprA; Region: surface_SprA; TIGR04189 411154000526 Motility related/secretion protein; Region: SprA_N; pfam14349 411154000527 Motility related/secretion protein; Region: SprA_N; pfam14349 411154000528 Motility related/secretion protein; Region: SprA_N; pfam14349 411154000529 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 411154000530 lipoyl attachment site [posttranslational modification]; other site 411154000531 VanZ like family; Region: VanZ; cl01971 411154000532 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 411154000533 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 411154000534 Polyprenyltransferase (cytochrome oxidase assembly factor) [Posttranslational modification, protein turnover, chaperones]; Region: CyoE; COG0109 411154000535 UbiA prenyltransferase family; Region: UbiA; pfam01040 411154000536 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 411154000537 Subunit I/III interface [polypeptide binding]; other site 411154000538 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 411154000539 Subunit I/III interface [polypeptide binding]; other site 411154000540 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 411154000541 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 411154000542 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 411154000543 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 411154000544 Cu(I) binding site [ion binding]; other site 411154000545 Protein of unknown function (DUF420); Region: DUF420; pfam04238 411154000546 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 411154000547 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 411154000548 Walker A/P-loop; other site 411154000549 ATP binding site [chemical binding]; other site 411154000550 Q-loop/lid; other site 411154000551 ABC transporter signature motif; other site 411154000552 Walker B; other site 411154000553 D-loop; other site 411154000554 H-loop/switch region; other site 411154000555 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 411154000556 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 411154000557 FtsX-like permease family; Region: FtsX; pfam02687 411154000558 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 411154000559 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 411154000560 FtsX-like permease family; Region: FtsX; pfam02687 411154000561 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 411154000562 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 411154000563 HlyD family secretion protein; Region: HlyD_3; pfam13437 411154000564 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 411154000565 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 411154000566 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 411154000567 HlyD family secretion protein; Region: HlyD_3; pfam13437 411154000568 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 411154000569 Glycoprotease family; Region: Peptidase_M22; pfam00814 411154000570 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 411154000571 Mechanosensitive ion channel; Region: MS_channel; pfam00924 411154000572 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 411154000573 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 411154000574 catalytic residues [active] 411154000575 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 411154000576 Phosphate transporter family; Region: PHO4; cl00396 411154000577 NifU-like domain; Region: NifU; cl00484 411154000578 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 411154000579 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 411154000580 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 411154000581 glutamate racemase; Provisional; Region: PRK00865 411154000582 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 411154000583 periplasmic chaperone; Provisional; Region: PRK10780 411154000584 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 411154000585 periplasmic chaperone; Provisional; Region: PRK10780 411154000586 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 411154000587 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 411154000588 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 411154000589 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 411154000590 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 411154000591 Surface antigen; Region: Bac_surface_Ag; pfam01103 411154000592 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 411154000593 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 411154000594 catalytic residue [active] 411154000595 putative FPP diphosphate binding site; other site 411154000596 putative FPP binding hydrophobic cleft; other site 411154000597 dimer interface [polypeptide binding]; other site 411154000598 putative IPP diphosphate binding site; other site 411154000599 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 411154000600 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01911 411154000601 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 411154000602 FOG: CBS domain [General function prediction only]; Region: COG0517 411154000603 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 411154000604 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 411154000605 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 411154000606 active site 411154000607 hydrophilic channel; other site 411154000608 dimerization interface [polypeptide binding]; other site 411154000609 catalytic residues [active] 411154000610 active site lid [active] 411154000611 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 411154000612 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 411154000613 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 411154000614 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 411154000615 catalytic triad [active] 411154000616 Membrane protein of unknown function; Region: DUF360; cl00850 411154000617 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 411154000618 Clp protease; Region: CLP_protease; pfam00574 411154000619 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 411154000620 oligomer interface [polypeptide binding]; other site 411154000621 active site residues [active] 411154000622 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 411154000623 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 411154000624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154000625 Walker A motif; other site 411154000626 ATP binding site [chemical binding]; other site 411154000627 Walker B motif; other site 411154000628 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 411154000629 Repair protein; Region: Repair_PSII; pfam04536 411154000630 Repair protein; Region: Repair_PSII; pfam04536 411154000631 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 411154000632 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 411154000633 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 411154000634 DNA binding residues [nucleotide binding] 411154000635 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 411154000636 Peptidase family M23; Region: Peptidase_M23; pfam01551 411154000637 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 411154000638 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 411154000639 motif 1; other site 411154000640 active site 411154000641 motif 2; other site 411154000642 motif 3; other site 411154000643 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 411154000644 GSCFA family; Region: GSCFA; pfam08885 411154000645 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 411154000646 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 411154000647 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 411154000648 cofactor binding site; other site 411154000649 metal binding site [ion binding]; metal-binding site 411154000650 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 411154000651 urocanate hydratase; Provisional; Region: PRK05414 411154000652 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 411154000653 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 411154000654 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 411154000655 catalytic residue [active] 411154000656 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 411154000657 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 411154000658 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 411154000659 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 411154000660 inhibitor-cofactor binding pocket; inhibition site 411154000661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154000662 catalytic residue [active] 411154000663 maltose O-acetyltransferase; Provisional; Region: PRK10092 411154000664 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 411154000665 active site 411154000666 substrate binding site [chemical binding]; other site 411154000667 trimer interface [polypeptide binding]; other site 411154000668 CoA binding site [chemical binding]; other site 411154000669 GH3 auxin-responsive promoter; Region: GH3; pfam03321 411154000670 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 411154000671 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 411154000672 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 411154000673 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 411154000674 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 411154000675 catalytic center binding site [active] 411154000676 ATP binding site [chemical binding]; other site 411154000677 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 411154000678 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 411154000679 Substrate-binding site [chemical binding]; other site 411154000680 Substrate specificity [chemical binding]; other site 411154000681 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 411154000682 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 411154000683 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 411154000684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154000685 Walker A/P-loop; other site 411154000686 ATP binding site [chemical binding]; other site 411154000687 Q-loop/lid; other site 411154000688 ABC transporter signature motif; other site 411154000689 Walker B; other site 411154000690 D-loop; other site 411154000691 H-loop/switch region; other site 411154000692 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 411154000693 MutS domain I; Region: MutS_I; pfam01624 411154000694 MutS domain II; Region: MutS_II; pfam05188 411154000695 MutS domain III; Region: MutS_III; pfam05192 411154000696 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 411154000697 Walker A/P-loop; other site 411154000698 ATP binding site [chemical binding]; other site 411154000699 Q-loop/lid; other site 411154000700 ABC transporter signature motif; other site 411154000701 Walker B; other site 411154000702 D-loop; other site 411154000703 H-loop/switch region; other site 411154000704 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 411154000705 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 411154000706 Methyltransferase domain; Region: Methyltransf_26; pfam13659 411154000707 Helix-turn-helix domain; Region: HTH_17; pfam12728 411154000708 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 411154000709 active site 411154000710 catalytic residues [active] 411154000711 DNA binding site [nucleotide binding] 411154000712 Int/Topo IB signature motif; other site 411154000713 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 411154000714 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 411154000715 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 411154000716 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 411154000717 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 411154000718 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 411154000719 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 411154000720 active site 411154000721 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 411154000722 metal binding site 2 [ion binding]; metal-binding site 411154000723 putative DNA binding helix; other site 411154000724 metal binding site 1 [ion binding]; metal-binding site 411154000725 dimer interface [polypeptide binding]; other site 411154000726 structural Zn2+ binding site [ion binding]; other site 411154000727 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 411154000728 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 411154000729 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 411154000730 Soluble P-type ATPase [General function prediction only]; Region: COG4087 411154000731 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 411154000732 non-specific DNA binding site [nucleotide binding]; other site 411154000733 salt bridge; other site 411154000734 Predicted transcriptional regulator [Transcription]; Region: COG2932 411154000735 sequence-specific DNA binding site [nucleotide binding]; other site 411154000736 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 411154000737 Catalytic site [active] 411154000738 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 411154000739 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 411154000740 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 411154000741 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 411154000742 inhibitor-cofactor binding pocket; inhibition site 411154000743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154000744 catalytic residue [active] 411154000745 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 411154000746 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 411154000747 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 411154000748 active site 411154000749 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 411154000750 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 411154000751 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 411154000752 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 411154000753 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 411154000754 Phosphotransferase enzyme family; Region: APH; pfam01636 411154000755 active site 411154000756 substrate binding site [chemical binding]; other site 411154000757 ATP binding site [chemical binding]; other site 411154000758 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 411154000759 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 411154000760 folate binding site [chemical binding]; other site 411154000761 NADP+ binding site [chemical binding]; other site 411154000762 2TM domain; Region: 2TM; pfam13239 411154000763 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 411154000764 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 411154000765 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 411154000766 catalytic residue [active] 411154000767 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 411154000768 Domain of unknown function (DUF427); Region: DUF427; pfam04248 411154000769 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 411154000770 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 411154000771 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 411154000772 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 411154000773 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 411154000774 thymidylate synthase; Reviewed; Region: thyA; PRK01827 411154000775 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 411154000776 dimerization interface [polypeptide binding]; other site 411154000777 active site 411154000778 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 411154000779 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 411154000780 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 411154000781 Nucleoside recognition; Region: Gate; pfam07670 411154000782 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 411154000783 Bifunctional nuclease; Region: DNase-RNase; pfam02577 411154000784 UvrB/uvrC motif; Region: UVR; pfam02151 411154000785 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 411154000786 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 411154000787 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 411154000788 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 411154000789 Ligand binding site [chemical binding]; other site 411154000790 Electron transfer flavoprotein domain; Region: ETF; pfam01012 411154000791 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 411154000792 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 411154000793 alpha subunit interface [polypeptide binding]; other site 411154000794 TPP binding site [chemical binding]; other site 411154000795 heterodimer interface [polypeptide binding]; other site 411154000796 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 411154000797 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154000798 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 411154000799 dimer interface [polypeptide binding]; other site 411154000800 substrate binding site [chemical binding]; other site 411154000801 metal binding sites [ion binding]; metal-binding site 411154000802 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 411154000803 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 411154000804 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 411154000805 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 411154000806 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 411154000807 putative DNA binding site [nucleotide binding]; other site 411154000808 putative homodimer interface [polypeptide binding]; other site 411154000809 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 411154000810 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 411154000811 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 411154000812 active site 411154000813 DNA binding site [nucleotide binding] 411154000814 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 411154000815 DNA binding site [nucleotide binding] 411154000816 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 411154000817 nucleotide binding site [chemical binding]; other site 411154000818 Uncharacterized conserved protein [Function unknown]; Region: COG4850 411154000819 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 411154000820 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 411154000821 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 411154000822 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 411154000823 Substrate-binding site [chemical binding]; other site 411154000824 Substrate specificity [chemical binding]; other site 411154000825 Domain of unknown function DUF302; Region: DUF302; pfam03625 411154000826 Domain of unknown function DUF302; Region: DUF302; pfam03625 411154000827 Domain of unknown function (DUF202); Region: DUF202; pfam02656 411154000828 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 411154000829 transmembrane helices; other site 411154000830 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 411154000831 TrkA-C domain; Region: TrkA_C; pfam02080 411154000832 TrkA-C domain; Region: TrkA_C; pfam02080 411154000833 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 411154000834 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 411154000835 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 411154000836 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 411154000837 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 411154000838 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 411154000839 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 411154000840 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 411154000841 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 411154000842 active site 411154000843 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 411154000844 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 411154000845 tetramer interface [polypeptide binding]; other site 411154000846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154000847 catalytic residue [active] 411154000848 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 411154000849 Ligand Binding Site [chemical binding]; other site 411154000850 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 411154000851 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 411154000852 putative ligand binding site [chemical binding]; other site 411154000853 NAD binding site [chemical binding]; other site 411154000854 dimerization interface [polypeptide binding]; other site 411154000855 catalytic site [active] 411154000856 acyl-coenzyme A oxidase; Region: PLN02526 411154000857 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 411154000858 active site 411154000859 S-adenosylmethionine synthetase; Validated; Region: PRK05250 411154000860 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 411154000861 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 411154000862 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 411154000863 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 411154000864 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 411154000865 homodimer interface [polypeptide binding]; other site 411154000866 substrate-cofactor binding pocket; other site 411154000867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154000868 catalytic residue [active] 411154000869 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 411154000870 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 411154000871 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 411154000872 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 411154000873 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 411154000874 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 411154000875 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 411154000876 homodimer interface [polypeptide binding]; other site 411154000877 substrate-cofactor binding pocket; other site 411154000878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154000879 catalytic residue [active] 411154000880 Rrf2 family protein; Region: rrf2_super; TIGR00738 411154000881 Transcriptional regulator; Region: Rrf2; pfam02082 411154000882 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 411154000883 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 411154000884 Active Sites [active] 411154000885 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 411154000886 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 411154000887 Active Sites [active] 411154000888 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 411154000889 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 411154000890 CysD dimerization site [polypeptide binding]; other site 411154000891 G1 box; other site 411154000892 putative GEF interaction site [polypeptide binding]; other site 411154000893 GTP/Mg2+ binding site [chemical binding]; other site 411154000894 Switch I region; other site 411154000895 G2 box; other site 411154000896 G3 box; other site 411154000897 Switch II region; other site 411154000898 G4 box; other site 411154000899 G5 box; other site 411154000900 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 411154000901 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 411154000902 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 411154000903 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 411154000904 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 411154000905 HEPN domain; Region: HEPN; pfam05168 411154000906 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 411154000907 active site 411154000908 SAM binding site [chemical binding]; other site 411154000909 homodimer interface [polypeptide binding]; other site 411154000910 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 411154000911 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 411154000912 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 411154000913 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 411154000914 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 411154000915 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 411154000916 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 411154000917 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 411154000918 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 411154000919 substrate binding pocket [chemical binding]; other site 411154000920 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 411154000921 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 411154000922 putative active site [active] 411154000923 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 411154000924 B12 binding site [chemical binding]; other site 411154000925 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 411154000926 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 411154000927 FAD binding site [chemical binding]; other site 411154000928 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 411154000929 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 411154000930 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 411154000931 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 411154000932 Walker A/P-loop; other site 411154000933 ATP binding site [chemical binding]; other site 411154000934 Q-loop/lid; other site 411154000935 ABC transporter signature motif; other site 411154000936 Walker B; other site 411154000937 D-loop; other site 411154000938 H-loop/switch region; other site 411154000939 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 411154000940 Prephenate dehydratase; Region: PDT; pfam00800 411154000941 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 411154000942 putative L-Phe binding site [chemical binding]; other site 411154000943 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 411154000944 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 411154000945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154000946 homodimer interface [polypeptide binding]; other site 411154000947 catalytic residue [active] 411154000948 prephenate dehydrogenase; Validated; Region: PRK08507 411154000949 Prephenate dehydrogenase; Region: PDH; pfam02153 411154000950 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 411154000951 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 411154000952 Chorismate mutase type II; Region: CM_2; smart00830 411154000953 GTPase RsgA; Reviewed; Region: PRK00098 411154000954 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 411154000955 RNA binding site [nucleotide binding]; other site 411154000956 homodimer interface [polypeptide binding]; other site 411154000957 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 411154000958 GTPase/Zn-binding domain interface [polypeptide binding]; other site 411154000959 GTP/Mg2+ binding site [chemical binding]; other site 411154000960 G4 box; other site 411154000961 G5 box; other site 411154000962 G1 box; other site 411154000963 Switch I region; other site 411154000964 G2 box; other site 411154000965 G3 box; other site 411154000966 Switch II region; other site 411154000967 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 411154000968 putative active site [active] 411154000969 dimerization interface [polypeptide binding]; other site 411154000970 putative tRNAtyr binding site [nucleotide binding]; other site 411154000971 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 411154000972 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 411154000973 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 411154000974 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 411154000975 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 411154000976 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 411154000977 homodimer interface [polypeptide binding]; other site 411154000978 metal binding site [ion binding]; metal-binding site 411154000979 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 411154000980 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 411154000981 hinge; other site 411154000982 active site 411154000983 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 411154000984 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 411154000985 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 411154000986 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 411154000987 FeS/SAM binding site; other site 411154000988 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 411154000989 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 411154000990 substrate binding pocket [chemical binding]; other site 411154000991 chain length determination region; other site 411154000992 substrate-Mg2+ binding site; other site 411154000993 catalytic residues [active] 411154000994 aspartate-rich region 1; other site 411154000995 active site lid residues [active] 411154000996 aspartate-rich region 2; other site 411154000997 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 411154000998 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 411154000999 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 411154001000 FeS/SAM binding site; other site 411154001001 Sulfatase; Region: Sulfatase; cl17466 411154001002 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 411154001003 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 411154001004 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 411154001005 DNA binding residues [nucleotide binding] 411154001006 dimerization interface [polypeptide binding]; other site 411154001007 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 411154001008 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154001009 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 411154001010 starch binding outer membrane protein SusD; Region: SusD; cd08977 411154001011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 411154001012 Putative glucoamylase; Region: Glycoamylase; pfam10091 411154001013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 411154001014 Putative glucoamylase; Region: Glycoamylase; pfam10091 411154001015 Predicted peptidase [General function prediction only]; Region: COG4099 411154001016 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 411154001017 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 411154001018 active site 411154001019 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 411154001020 sugar binding site [chemical binding]; other site 411154001021 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 411154001022 Interdomain contacts; other site 411154001023 Cytokine receptor motif; other site 411154001024 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 411154001025 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 411154001026 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 411154001027 beta-D-glucuronidase; Provisional; Region: PRK10150 411154001028 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 411154001029 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 411154001030 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 411154001031 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 411154001032 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 411154001033 active site 411154001034 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 411154001035 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 411154001036 Yqey-like protein; Region: YqeY; pfam09424 411154001037 HYR domain; Region: HYR; pfam02494 411154001038 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 411154001039 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 411154001040 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 411154001041 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 411154001042 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 411154001043 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 411154001044 substrate binding site [chemical binding]; other site 411154001045 hexamer interface [polypeptide binding]; other site 411154001046 metal binding site [ion binding]; metal-binding site 411154001047 Sensors of blue-light using FAD; Region: BLUF; pfam04940 411154001048 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 411154001049 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 411154001050 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 411154001051 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 411154001052 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 411154001053 DNA binding residues [nucleotide binding] 411154001054 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 411154001055 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 411154001056 RNase E interface [polypeptide binding]; other site 411154001057 trimer interface [polypeptide binding]; other site 411154001058 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 411154001059 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 411154001060 RNase E interface [polypeptide binding]; other site 411154001061 trimer interface [polypeptide binding]; other site 411154001062 active site 411154001063 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 411154001064 putative nucleic acid binding region [nucleotide binding]; other site 411154001065 G-X-X-G motif; other site 411154001066 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 411154001067 RNA binding site [nucleotide binding]; other site 411154001068 domain interface; other site 411154001069 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 411154001070 16S/18S rRNA binding site [nucleotide binding]; other site 411154001071 S13e-L30e interaction site [polypeptide binding]; other site 411154001072 25S rRNA binding site [nucleotide binding]; other site 411154001073 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 411154001074 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 411154001075 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 411154001076 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 411154001077 active site 411154001078 intersubunit interface [polypeptide binding]; other site 411154001079 zinc binding site [ion binding]; other site 411154001080 Na+ binding site [ion binding]; other site 411154001081 Surface antigen; Region: Bac_surface_Ag; pfam01103 411154001082 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 411154001083 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 411154001084 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 411154001085 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 411154001086 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 411154001087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 411154001088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154001089 S-adenosylmethionine binding site [chemical binding]; other site 411154001090 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 411154001091 TrkA-N domain; Region: TrkA_N; pfam02254 411154001092 TrkA-C domain; Region: TrkA_C; pfam02080 411154001093 TrkA-N domain; Region: TrkA_N; pfam02254 411154001094 TrkA-C domain; Region: TrkA_C; pfam02080 411154001095 Cation transport protein; Region: TrkH; cl17365 411154001096 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 411154001097 aspartate aminotransferase; Provisional; Region: PRK05764 411154001098 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 411154001099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154001100 homodimer interface [polypeptide binding]; other site 411154001101 catalytic residue [active] 411154001102 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 411154001103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154001104 S-adenosylmethionine binding site [chemical binding]; other site 411154001105 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 411154001106 HYR domain; Region: HYR; pfam02494 411154001107 HYR domain; Region: HYR; pfam02494 411154001108 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 411154001109 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 411154001110 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 411154001111 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 411154001112 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 411154001113 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 411154001114 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 411154001115 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 411154001116 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 411154001117 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 411154001118 Glutamate binding site [chemical binding]; other site 411154001119 NAD binding site [chemical binding]; other site 411154001120 catalytic residues [active] 411154001121 NRDE protein; Region: NRDE; cl01315 411154001122 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 411154001123 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 411154001124 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 411154001125 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 411154001126 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 411154001127 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 411154001128 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 411154001129 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 411154001130 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 411154001131 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 411154001132 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 411154001133 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 411154001134 catalytic loop [active] 411154001135 iron binding site [ion binding]; other site 411154001136 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 411154001137 FAD binding pocket [chemical binding]; other site 411154001138 FAD binding motif [chemical binding]; other site 411154001139 phosphate binding motif [ion binding]; other site 411154001140 beta-alpha-beta structure motif; other site 411154001141 NAD binding pocket [chemical binding]; other site 411154001142 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 411154001143 ApbE family; Region: ApbE; pfam02424 411154001144 Methyltransferase domain; Region: Methyltransf_23; pfam13489 411154001145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154001146 HNH endonuclease; Region: HNH_3; pfam13392 411154001147 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 411154001148 active site 411154001149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 411154001150 active site 411154001151 motif I; other site 411154001152 motif II; other site 411154001153 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 411154001154 catalytic residues [active] 411154001155 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 411154001156 phosphoglyceromutase; Provisional; Region: PRK05434 411154001157 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 411154001158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 411154001159 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 411154001160 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 411154001161 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 411154001162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 411154001163 Coenzyme A binding pocket [chemical binding]; other site 411154001164 Clp protease; Region: CLP_protease; pfam00574 411154001165 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 411154001166 oligomer interface [polypeptide binding]; other site 411154001167 active site residues [active] 411154001168 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 411154001169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 411154001170 Coenzyme A binding pocket [chemical binding]; other site 411154001171 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 411154001172 transcription termination factor Rho; Provisional; Region: PRK12608 411154001173 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 411154001174 RNA binding site [nucleotide binding]; other site 411154001175 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 411154001176 multimer interface [polypeptide binding]; other site 411154001177 Walker A motif; other site 411154001178 ATP binding site [chemical binding]; other site 411154001179 Walker B motif; other site 411154001180 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 411154001181 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 411154001182 active site 411154001183 metal binding site [ion binding]; metal-binding site 411154001184 homotetramer interface [polypeptide binding]; other site 411154001185 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 411154001186 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 411154001187 dimerization interface 3.5A [polypeptide binding]; other site 411154001188 active site 411154001189 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 411154001190 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 411154001191 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 411154001192 Walker A/P-loop; other site 411154001193 ATP binding site [chemical binding]; other site 411154001194 Q-loop/lid; other site 411154001195 ABC transporter signature motif; other site 411154001196 Walker B; other site 411154001197 D-loop; other site 411154001198 H-loop/switch region; other site 411154001199 Spondin_N; Region: Spond_N; pfam06468 411154001200 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 411154001201 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 411154001202 dihydropteroate synthase; Region: DHPS; TIGR01496 411154001203 substrate binding pocket [chemical binding]; other site 411154001204 dimer interface [polypeptide binding]; other site 411154001205 inhibitor binding site; inhibition site 411154001206 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 411154001207 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 411154001208 Predicted membrane protein [Function unknown]; Region: COG2259 411154001209 triosephosphate isomerase; Provisional; Region: PRK14567 411154001210 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 411154001211 substrate binding site [chemical binding]; other site 411154001212 dimer interface [polypeptide binding]; other site 411154001213 catalytic triad [active] 411154001214 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 411154001215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 411154001216 S-adenosylmethionine binding site [chemical binding]; other site 411154001217 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 411154001218 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 411154001219 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 411154001220 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 411154001221 catalytic loop [active] 411154001222 iron binding site [ion binding]; other site 411154001223 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 411154001224 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 411154001225 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 411154001226 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 411154001227 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 411154001228 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 411154001229 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 411154001230 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 411154001231 catalytic loop [active] 411154001232 iron binding site [ion binding]; other site 411154001233 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 411154001234 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 411154001235 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 411154001236 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 411154001237 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 411154001238 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 411154001239 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 411154001240 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 411154001241 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 411154001242 catalytic residue [active] 411154001243 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 411154001244 XdhC Rossmann domain; Region: XdhC_C; pfam13478 411154001245 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 411154001246 Ligand binding site; other site 411154001247 metal-binding site 411154001248 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 411154001249 MoaE interaction surface [polypeptide binding]; other site 411154001250 MoeB interaction surface [polypeptide binding]; other site 411154001251 thiocarboxylated glycine; other site 411154001252 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 411154001253 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 411154001254 ATP binding site [chemical binding]; other site 411154001255 substrate interface [chemical binding]; other site 411154001256 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 411154001257 active site residue [active] 411154001258 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 411154001259 MoaE homodimer interface [polypeptide binding]; other site 411154001260 MoaD interaction [polypeptide binding]; other site 411154001261 active site residues [active] 411154001262 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 411154001263 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 411154001264 trimer interface [polypeptide binding]; other site 411154001265 dimer interface [polypeptide binding]; other site 411154001266 putative active site [active] 411154001267 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 411154001268 MPT binding site; other site 411154001269 trimer interface [polypeptide binding]; other site 411154001270 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 411154001271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 411154001272 FeS/SAM binding site; other site 411154001273 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 411154001274 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 411154001275 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 411154001276 dimer interface [polypeptide binding]; other site 411154001277 putative functional site; other site 411154001278 putative MPT binding site; other site 411154001279 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 411154001280 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 411154001281 Tetratricopeptide repeat; Region: TPR_12; pfam13424 411154001282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154001283 binding surface 411154001284 TPR motif; other site 411154001285 Tetratricopeptide repeat; Region: TPR_12; pfam13424 411154001286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 411154001287 Histidine kinase; Region: HisKA_3; pfam07730 411154001288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154001289 ATP binding site [chemical binding]; other site 411154001290 Mg2+ binding site [ion binding]; other site 411154001291 G-X-G motif; other site 411154001292 Response regulator receiver domain; Region: Response_reg; pfam00072 411154001293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154001294 active site 411154001295 phosphorylation site [posttranslational modification] 411154001296 intermolecular recognition site; other site 411154001297 dimerization interface [polypeptide binding]; other site 411154001298 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 411154001299 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154001300 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 411154001301 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 411154001302 active site 411154001303 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 411154001304 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 411154001305 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 411154001306 Penicillinase repressor; Region: Pencillinase_R; pfam03965 411154001307 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154001308 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 411154001309 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 411154001310 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 411154001311 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 411154001312 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 411154001313 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 411154001314 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 411154001315 dimerization interface [polypeptide binding]; other site 411154001316 ATP binding site [chemical binding]; other site 411154001317 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14273 411154001318 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154001319 Walker A/P-loop; other site 411154001320 ATP binding site [chemical binding]; other site 411154001321 Q-loop/lid; other site 411154001322 ABC transporter signature motif; other site 411154001323 Walker B; other site 411154001324 D-loop; other site 411154001325 peptide chain release factor 1; Validated; Region: prfA; PRK00591 411154001326 This domain is found in peptide chain release factors; Region: PCRF; smart00937 411154001327 RF-1 domain; Region: RF-1; pfam00472 411154001328 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 411154001329 active site 411154001330 dimer interface [polypeptide binding]; other site 411154001331 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 411154001332 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 411154001333 intersubunit interface [polypeptide binding]; other site 411154001334 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 411154001335 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 411154001336 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 411154001337 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 411154001338 putative active site [active] 411154001339 putative substrate binding site [chemical binding]; other site 411154001340 putative cosubstrate binding site; other site 411154001341 catalytic site [active] 411154001342 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 411154001343 B12 binding site [chemical binding]; other site 411154001344 cobalt ligand [ion binding]; other site 411154001345 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 411154001346 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 411154001347 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 411154001348 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 411154001349 DNA-binding interface [nucleotide binding]; DNA binding site 411154001350 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 411154001351 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 411154001352 dimerization interface [polypeptide binding]; other site 411154001353 putative Zn2+ binding site [ion binding]; other site 411154001354 putative DNA binding site [nucleotide binding]; other site 411154001355 AsnC family; Region: AsnC_trans_reg; pfam01037 411154001356 Protein of unknown function (DUF1328); Region: DUF1328; pfam07043 411154001357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154001358 Major Facilitator Superfamily; Region: MFS_1; pfam07690 411154001359 putative substrate translocation pore; other site 411154001360 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 411154001361 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 411154001362 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 411154001363 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 411154001364 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 411154001365 Nitrogen regulatory protein P-II; Region: P-II; smart00938 411154001366 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 411154001367 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 411154001368 putative hydrophobic ligand binding site [chemical binding]; other site 411154001369 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 411154001370 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 411154001371 metal binding site [ion binding]; metal-binding site 411154001372 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 411154001373 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 411154001374 homodimer interface [polypeptide binding]; other site 411154001375 substrate-cofactor binding pocket; other site 411154001376 catalytic residue [active] 411154001377 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 411154001378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 411154001379 TIGR01777 family protein; Region: yfcH 411154001380 NAD(P) binding site [chemical binding]; other site 411154001381 active site 411154001382 YceI-like domain; Region: YceI; pfam04264 411154001383 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 411154001384 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 411154001385 dimer interface [polypeptide binding]; other site 411154001386 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 411154001387 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 411154001388 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 411154001389 HSP70 interaction site [polypeptide binding]; other site 411154001390 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 411154001391 substrate binding site [polypeptide binding]; other site 411154001392 dimer interface [polypeptide binding]; other site 411154001393 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 411154001394 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 411154001395 Walker A/P-loop; other site 411154001396 ATP binding site [chemical binding]; other site 411154001397 Q-loop/lid; other site 411154001398 ABC transporter signature motif; other site 411154001399 Walker B; other site 411154001400 D-loop; other site 411154001401 H-loop/switch region; other site 411154001402 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 411154001403 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 411154001404 Mechanosensitive ion channel; Region: MS_channel; pfam00924 411154001405 Response regulator receiver domain; Region: Response_reg; pfam00072 411154001406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154001407 active site 411154001408 phosphorylation site [posttranslational modification] 411154001409 intermolecular recognition site; other site 411154001410 dimerization interface [polypeptide binding]; other site 411154001411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154001412 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 411154001413 Walker A motif; other site 411154001414 ATP binding site [chemical binding]; other site 411154001415 Walker B motif; other site 411154001416 arginine finger; other site 411154001417 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 411154001418 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 411154001419 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 411154001420 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 411154001421 PA/protease or protease-like domain interface [polypeptide binding]; other site 411154001422 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 411154001423 Peptidase family M28; Region: Peptidase_M28; pfam04389 411154001424 metal binding site [ion binding]; metal-binding site 411154001425 multidrug efflux protein; Reviewed; Region: PRK01766 411154001426 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 411154001427 cation binding site [ion binding]; other site 411154001428 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 411154001429 active site 411154001430 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 411154001431 membrane ATPase/protein kinase; Provisional; Region: PRK09435 411154001432 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 411154001433 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 411154001434 Walker A; other site 411154001435 G1 box; other site 411154001436 GTP/Mg2+ binding site [chemical binding]; other site 411154001437 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 411154001438 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 411154001439 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 411154001440 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 411154001441 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 411154001442 DNA binding residues [nucleotide binding] 411154001443 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 411154001444 KMSKS motif; other site 411154001445 Peptidase family M23; Region: Peptidase_M23; pfam01551 411154001446 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 411154001447 GIY-YIG motif/motif A; other site 411154001448 putative active site [active] 411154001449 putative metal binding site [ion binding]; other site 411154001450 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 411154001451 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 411154001452 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 411154001453 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 411154001454 DNA binding residues [nucleotide binding] 411154001455 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 411154001456 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 411154001457 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 411154001458 nucleotide binding region [chemical binding]; other site 411154001459 ATP-binding site [chemical binding]; other site 411154001460 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 411154001461 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 411154001462 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 411154001463 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 411154001464 Walker A/P-loop; other site 411154001465 ATP binding site [chemical binding]; other site 411154001466 Q-loop/lid; other site 411154001467 ABC transporter signature motif; other site 411154001468 Walker B; other site 411154001469 D-loop; other site 411154001470 H-loop/switch region; other site 411154001471 Methyltransferase domain; Region: Methyltransf_24; pfam13578 411154001472 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 411154001473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154001474 Walker A/P-loop; other site 411154001475 ATP binding site [chemical binding]; other site 411154001476 Q-loop/lid; other site 411154001477 ABC transporter signature motif; other site 411154001478 Walker B; other site 411154001479 D-loop; other site 411154001480 H-loop/switch region; other site 411154001481 ABC transporter; Region: ABC_tran_2; pfam12848 411154001482 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 411154001483 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 411154001484 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 411154001485 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 411154001486 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 411154001487 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 411154001488 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 411154001489 four helix bundle protein; Region: TIGR02436 411154001490 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 411154001491 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 411154001492 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 411154001493 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 411154001494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154001495 S-adenosylmethionine binding site [chemical binding]; other site 411154001496 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 411154001497 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 411154001498 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 411154001499 Walker A/P-loop; other site 411154001500 ATP binding site [chemical binding]; other site 411154001501 Q-loop/lid; other site 411154001502 ABC transporter signature motif; other site 411154001503 Walker B; other site 411154001504 D-loop; other site 411154001505 H-loop/switch region; other site 411154001506 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 411154001507 putative carbohydrate binding site [chemical binding]; other site 411154001508 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 411154001509 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 411154001510 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 411154001511 inhibitor-cofactor binding pocket; inhibition site 411154001512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154001513 catalytic residue [active] 411154001514 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 411154001515 active site 411154001516 substrate binding site [chemical binding]; other site 411154001517 cosubstrate binding site; other site 411154001518 catalytic site [active] 411154001519 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 411154001520 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 411154001521 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 411154001522 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 411154001523 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 411154001524 NADP-binding site; other site 411154001525 homotetramer interface [polypeptide binding]; other site 411154001526 substrate binding site [chemical binding]; other site 411154001527 homodimer interface [polypeptide binding]; other site 411154001528 active site 411154001529 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 411154001530 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 411154001531 NADP binding site [chemical binding]; other site 411154001532 active site 411154001533 putative substrate binding site [chemical binding]; other site 411154001534 putative glycosyl transferase; Provisional; Region: PRK10063 411154001535 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 411154001536 metal-binding site 411154001537 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 411154001538 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 411154001539 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 411154001540 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 411154001541 GDP-Fucose binding site [chemical binding]; other site 411154001542 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 411154001543 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 411154001544 active site 411154001545 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 411154001546 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 411154001547 active site 411154001548 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 411154001549 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 411154001550 active site 411154001551 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 411154001552 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 411154001553 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 411154001554 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 411154001555 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 411154001556 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 411154001557 active site 411154001558 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 411154001559 NeuB family; Region: NeuB; pfam03102 411154001560 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 411154001561 NeuB binding interface [polypeptide binding]; other site 411154001562 putative substrate binding site [chemical binding]; other site 411154001563 Methyltransferase domain; Region: Methyltransf_18; pfam12847 411154001564 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 411154001565 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 411154001566 active site 411154001567 homodimer interface [polypeptide binding]; other site 411154001568 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 411154001569 ligand binding site; other site 411154001570 tetramer interface; other site 411154001571 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 411154001572 active site 411154001573 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 411154001574 dimer interface [polypeptide binding]; other site 411154001575 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 411154001576 Ligand Binding Site [chemical binding]; other site 411154001577 Molecular Tunnel; other site 411154001578 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 411154001579 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 411154001580 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 411154001581 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 411154001582 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 411154001583 active site 411154001584 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 411154001585 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 411154001586 active site 411154001587 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 411154001588 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 411154001589 active site 411154001590 Methyltransferase domain; Region: Methyltransf_31; pfam13847 411154001591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154001592 S-adenosylmethionine binding site [chemical binding]; other site 411154001593 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 411154001594 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 411154001595 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 411154001596 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 411154001597 putative ADP-binding pocket [chemical binding]; other site 411154001598 O-Antigen ligase; Region: Wzy_C; pfam04932 411154001599 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 411154001600 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 411154001601 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 411154001602 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 411154001603 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 411154001604 Bacterial sugar transferase; Region: Bac_transf; pfam02397 411154001605 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 411154001606 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 411154001607 putative active site [active] 411154001608 catalytic triad [active] 411154001609 putative dimer interface [polypeptide binding]; other site 411154001610 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 411154001611 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 411154001612 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 411154001613 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 411154001614 Walker A/P-loop; other site 411154001615 ATP binding site [chemical binding]; other site 411154001616 Q-loop/lid; other site 411154001617 ABC transporter signature motif; other site 411154001618 Walker B; other site 411154001619 D-loop; other site 411154001620 H-loop/switch region; other site 411154001621 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 411154001622 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 411154001623 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 411154001624 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 411154001625 putative active site [active] 411154001626 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 411154001627 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 411154001628 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 411154001629 ATP binding site [chemical binding]; other site 411154001630 putative Mg++ binding site [ion binding]; other site 411154001631 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 411154001632 nucleotide binding region [chemical binding]; other site 411154001633 ATP-binding site [chemical binding]; other site 411154001634 RQC domain; Region: RQC; pfam09382 411154001635 HRDC domain; Region: HRDC; pfam00570 411154001636 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 411154001637 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 411154001638 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 411154001639 PYR/PP interface [polypeptide binding]; other site 411154001640 dimer interface [polypeptide binding]; other site 411154001641 TPP binding site [chemical binding]; other site 411154001642 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 411154001643 transketolase; Reviewed; Region: PRK05899 411154001644 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 411154001645 TPP-binding site [chemical binding]; other site 411154001646 dimer interface [polypeptide binding]; other site 411154001647 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 411154001648 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 411154001649 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 411154001650 Predicted permeases [General function prediction only]; Region: COG0795 411154001651 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 411154001652 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 411154001653 replicative DNA helicase; Region: DnaB; TIGR00665 411154001654 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 411154001655 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 411154001656 Walker A motif; other site 411154001657 ATP binding site [chemical binding]; other site 411154001658 Walker B motif; other site 411154001659 DNA binding loops [nucleotide binding] 411154001660 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 411154001661 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 411154001662 23S rRNA binding site [nucleotide binding]; other site 411154001663 L21 binding site [polypeptide binding]; other site 411154001664 L13 binding site [polypeptide binding]; other site 411154001665 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 411154001666 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 411154001667 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 411154001668 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 411154001669 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 411154001670 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 411154001671 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 411154001672 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 411154001673 active site 411154001674 dimer interface [polypeptide binding]; other site 411154001675 motif 1; other site 411154001676 motif 2; other site 411154001677 motif 3; other site 411154001678 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 411154001679 anticodon binding site; other site 411154001680 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 411154001681 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154001682 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 411154001683 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154001684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154001685 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 411154001686 putative substrate translocation pore; other site 411154001687 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 411154001688 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 411154001689 ATP binding site [chemical binding]; other site 411154001690 putative Mg++ binding site [ion binding]; other site 411154001691 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 411154001692 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 411154001693 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 411154001694 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 411154001695 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 411154001696 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 411154001697 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 411154001698 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 411154001699 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 411154001700 protein binding site [polypeptide binding]; other site 411154001701 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 411154001702 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 411154001703 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 411154001704 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 411154001705 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 411154001706 YceG-like family; Region: YceG; pfam02618 411154001707 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 411154001708 dimerization interface [polypeptide binding]; other site 411154001709 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 411154001710 putative SAM binding site [chemical binding]; other site 411154001711 homodimer interface [polypeptide binding]; other site 411154001712 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 411154001713 Low molecular weight phosphatase family; Region: LMWPc; cd00115 411154001714 active site 411154001715 DnaA N-terminal domain; Region: DnaA_N; pfam11638 411154001716 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 411154001717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154001718 Walker A motif; other site 411154001719 ATP binding site [chemical binding]; other site 411154001720 Walker B motif; other site 411154001721 arginine finger; other site 411154001722 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 411154001723 DnaA box-binding interface [nucleotide binding]; other site 411154001724 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 411154001725 active site 411154001726 Uncharacterized conserved protein [Function unknown]; Region: COG1739 411154001727 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 411154001728 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 411154001729 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 411154001730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 411154001731 motif II; other site 411154001732 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 411154001733 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 411154001734 catalytic motif [active] 411154001735 Zn binding site [ion binding]; other site 411154001736 RibD C-terminal domain; Region: RibD_C; pfam01872 411154001737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 411154001738 Coenzyme A binding pocket [chemical binding]; other site 411154001739 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 411154001740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154001741 S-adenosylmethionine binding site [chemical binding]; other site 411154001742 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 411154001743 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 411154001744 active site 411154001745 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 411154001746 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 411154001747 nucleotide binding pocket [chemical binding]; other site 411154001748 K-X-D-G motif; other site 411154001749 catalytic site [active] 411154001750 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 411154001751 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 411154001752 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 411154001753 DNA binding site [nucleotide binding] 411154001754 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 411154001755 Dimer interface [polypeptide binding]; other site 411154001756 BRCT sequence motif; other site 411154001757 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 411154001758 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 411154001759 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 411154001760 active site 411154001761 metal binding site [ion binding]; metal-binding site 411154001762 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 411154001763 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 411154001764 dihydrodipicolinate synthase; Region: dapA; TIGR00674 411154001765 dimer interface [polypeptide binding]; other site 411154001766 active site 411154001767 catalytic residue [active] 411154001768 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 411154001769 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 411154001770 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 411154001771 Flavoprotein; Region: Flavoprotein; pfam02441 411154001772 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 411154001773 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 411154001774 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 411154001775 Walker A/P-loop; other site 411154001776 ATP binding site [chemical binding]; other site 411154001777 Q-loop/lid; other site 411154001778 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 411154001779 ABC transporter signature motif; other site 411154001780 Walker B; other site 411154001781 D-loop; other site 411154001782 H-loop/switch region; other site 411154001783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 411154001784 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 411154001785 NAD(P) binding site [chemical binding]; other site 411154001786 active site 411154001787 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 411154001788 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 411154001789 active site 411154001790 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 411154001791 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 411154001792 CoA-binding site [chemical binding]; other site 411154001793 ATP-binding [chemical binding]; other site 411154001794 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 411154001795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154001796 dimer interface [polypeptide binding]; other site 411154001797 phosphorylation site [posttranslational modification] 411154001798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154001799 ATP binding site [chemical binding]; other site 411154001800 Mg2+ binding site [ion binding]; other site 411154001801 G-X-G motif; other site 411154001802 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 411154001803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154001804 active site 411154001805 phosphorylation site [posttranslational modification] 411154001806 intermolecular recognition site; other site 411154001807 dimerization interface [polypeptide binding]; other site 411154001808 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 411154001809 DNA binding site [nucleotide binding] 411154001810 HYR domain; Region: HYR; pfam02494 411154001811 HYR domain; Region: HYR; pfam02494 411154001812 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 411154001813 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 411154001814 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 411154001815 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 411154001816 Ion transport protein; Region: Ion_trans; pfam00520 411154001817 Ion channel; Region: Ion_trans_2; pfam07885 411154001818 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 411154001819 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 411154001820 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 411154001821 active site 411154001822 catalytic site [active] 411154001823 substrate binding site [chemical binding]; other site 411154001824 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 411154001825 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 411154001826 GIY-YIG motif/motif A; other site 411154001827 active site 411154001828 catalytic site [active] 411154001829 putative DNA binding site [nucleotide binding]; other site 411154001830 metal binding site [ion binding]; metal-binding site 411154001831 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 411154001832 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 411154001833 catalytic residue [active] 411154001834 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 411154001835 Uncharacterized conserved protein [Function unknown]; Region: COG4198 411154001836 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 411154001837 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 411154001838 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 411154001839 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 411154001840 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 411154001841 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 411154001842 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 411154001843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154001844 S-adenosylmethionine binding site [chemical binding]; other site 411154001845 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 411154001846 Peptidase family M28; Region: Peptidase_M28; pfam04389 411154001847 metal binding site [ion binding]; metal-binding site 411154001848 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 411154001849 Int/Topo IB signature motif; other site 411154001850 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 411154001851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 411154001852 non-specific DNA binding site [nucleotide binding]; other site 411154001853 salt bridge; other site 411154001854 sequence-specific DNA binding site [nucleotide binding]; other site 411154001855 HsdM N-terminal domain; Region: HsdM_N; pfam12161 411154001856 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 411154001857 Methyltransferase domain; Region: Methyltransf_26; pfam13659 411154001858 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154001859 Walker B; other site 411154001860 D-loop; other site 411154001861 H-loop/switch region; other site 411154001862 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 411154001863 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 411154001864 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 411154001865 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 411154001866 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 411154001867 ATP binding site [chemical binding]; other site 411154001868 putative Mg++ binding site [ion binding]; other site 411154001869 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 411154001870 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 411154001871 Low molecular weight phosphatase family; Region: LMWPc; cl00105 411154001872 active site 411154001873 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 411154001874 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 411154001875 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 411154001876 nudix motif; other site 411154001877 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 411154001878 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 411154001879 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154001880 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 411154001881 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 411154001882 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 411154001883 starch binding outer membrane protein SusD; Region: SusD; cd08977 411154001884 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 411154001885 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 411154001886 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 411154001887 substrate binding site [chemical binding]; other site 411154001888 active site 411154001889 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 411154001890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 411154001891 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 411154001892 substrate binding site [chemical binding]; other site 411154001893 active site 411154001894 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 411154001895 substrate binding site [chemical binding]; other site 411154001896 active site 411154001897 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 411154001898 active site 411154001899 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 411154001900 ribulokinase; Provisional; Region: PRK04123 411154001901 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 411154001902 N- and C-terminal domain interface [polypeptide binding]; other site 411154001903 active site 411154001904 MgATP binding site [chemical binding]; other site 411154001905 catalytic site [active] 411154001906 metal binding site [ion binding]; metal-binding site 411154001907 carbohydrate binding site [chemical binding]; other site 411154001908 homodimer interface [polypeptide binding]; other site 411154001909 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 411154001910 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 411154001911 intersubunit interface [polypeptide binding]; other site 411154001912 active site 411154001913 Zn2+ binding site [ion binding]; other site 411154001914 L-arabinose isomerase; Provisional; Region: PRK02929 411154001915 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 411154001916 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 411154001917 trimer interface [polypeptide binding]; other site 411154001918 putative substrate binding site [chemical binding]; other site 411154001919 putative metal binding site [ion binding]; other site 411154001920 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 411154001921 active site 411154001922 catalytic residues [active] 411154001923 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 411154001924 Na binding site [ion binding]; other site 411154001925 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 411154001926 active site 411154001927 intersubunit interactions; other site 411154001928 catalytic residue [active] 411154001929 transketolase; Reviewed; Region: PRK05899 411154001930 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 411154001931 TPP-binding site [chemical binding]; other site 411154001932 dimer interface [polypeptide binding]; other site 411154001933 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 411154001934 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 411154001935 PYR/PP interface [polypeptide binding]; other site 411154001936 dimer interface [polypeptide binding]; other site 411154001937 TPP binding site [chemical binding]; other site 411154001938 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 411154001939 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 411154001940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154001941 binding surface 411154001942 TPR motif; other site 411154001943 Tetratricopeptide repeat; Region: TPR_16; pfam13432 411154001944 Tetratricopeptide repeat; Region: TPR_16; pfam13432 411154001945 Outer membrane efflux protein; Region: OEP; pfam02321 411154001946 Outer membrane efflux protein; Region: OEP; pfam02321 411154001947 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 411154001948 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 411154001949 Walker A/P-loop; other site 411154001950 ATP binding site [chemical binding]; other site 411154001951 Q-loop/lid; other site 411154001952 ABC transporter signature motif; other site 411154001953 Walker B; other site 411154001954 D-loop; other site 411154001955 H-loop/switch region; other site 411154001956 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 411154001957 FtsX-like permease family; Region: FtsX; pfam02687 411154001958 FtsX-like permease family; Region: FtsX; pfam02687 411154001959 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 411154001960 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 411154001961 FtsX-like permease family; Region: FtsX; pfam02687 411154001962 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 411154001963 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 411154001964 FtsX-like permease family; Region: FtsX; pfam02687 411154001965 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 411154001966 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 411154001967 FtsX-like permease family; Region: FtsX; pfam02687 411154001968 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 411154001969 FtsX-like permease family; Region: FtsX; pfam02687 411154001970 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 411154001971 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 411154001972 FtsX-like permease family; Region: FtsX; pfam02687 411154001973 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 411154001974 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 411154001975 FtsX-like permease family; Region: FtsX; pfam02687 411154001976 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 411154001977 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 411154001978 FtsX-like permease family; Region: FtsX; pfam02687 411154001979 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 411154001980 FtsX-like permease family; Region: FtsX; pfam02687 411154001981 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 411154001982 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 411154001983 Walker A/P-loop; other site 411154001984 ATP binding site [chemical binding]; other site 411154001985 Q-loop/lid; other site 411154001986 ABC transporter signature motif; other site 411154001987 Walker B; other site 411154001988 D-loop; other site 411154001989 H-loop/switch region; other site 411154001990 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 411154001991 HlyD family secretion protein; Region: HlyD_3; pfam13437 411154001992 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 411154001993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154001994 active site 411154001995 phosphorylation site [posttranslational modification] 411154001996 intermolecular recognition site; other site 411154001997 dimerization interface [polypeptide binding]; other site 411154001998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154001999 Walker A motif; other site 411154002000 ATP binding site [chemical binding]; other site 411154002001 Walker B motif; other site 411154002002 arginine finger; other site 411154002003 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 411154002004 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 411154002005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154002006 ATP binding site [chemical binding]; other site 411154002007 Mg2+ binding site [ion binding]; other site 411154002008 G-X-G motif; other site 411154002009 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 411154002010 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 411154002011 conserved cys residue [active] 411154002012 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 411154002013 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 411154002014 Cl- selectivity filter; other site 411154002015 Cl- binding residues [ion binding]; other site 411154002016 pore gating glutamate residue; other site 411154002017 dimer interface [polypeptide binding]; other site 411154002018 Uncharacterized conserved protein [Function unknown]; Region: COG3189 411154002019 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 411154002020 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 411154002021 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 411154002022 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 411154002023 NAD(P) binding site [chemical binding]; other site 411154002024 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 411154002025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154002026 active site 411154002027 phosphorylation site [posttranslational modification] 411154002028 intermolecular recognition site; other site 411154002029 dimerization interface [polypeptide binding]; other site 411154002030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154002031 Walker A motif; other site 411154002032 ATP binding site [chemical binding]; other site 411154002033 Walker B motif; other site 411154002034 arginine finger; other site 411154002035 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 411154002036 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154002037 dimer interface [polypeptide binding]; other site 411154002038 phosphorylation site [posttranslational modification] 411154002039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154002040 ATP binding site [chemical binding]; other site 411154002041 Mg2+ binding site [ion binding]; other site 411154002042 G-X-G motif; other site 411154002043 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 411154002044 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 411154002045 potential catalytic triad [active] 411154002046 conserved cys residue [active] 411154002047 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 411154002048 Ligand Binding Site [chemical binding]; other site 411154002049 phosphoserine phosphatase SerB; Region: serB; TIGR00338 411154002050 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 411154002051 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 411154002052 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 411154002053 ligand binding site [chemical binding]; other site 411154002054 NAD binding site [chemical binding]; other site 411154002055 tetramer interface [polypeptide binding]; other site 411154002056 catalytic site [active] 411154002057 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 411154002058 L-serine binding site [chemical binding]; other site 411154002059 ACT domain interface; other site 411154002060 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 411154002061 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 411154002062 tetrameric interface [polypeptide binding]; other site 411154002063 activator binding site; other site 411154002064 NADP binding site [chemical binding]; other site 411154002065 substrate binding site [chemical binding]; other site 411154002066 catalytic residues [active] 411154002067 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 411154002068 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 411154002069 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 411154002070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154002071 active site 411154002072 phosphorylation site [posttranslational modification] 411154002073 intermolecular recognition site; other site 411154002074 dimerization interface [polypeptide binding]; other site 411154002075 LytTr DNA-binding domain; Region: LytTR; smart00850 411154002076 Histidine kinase; Region: His_kinase; pfam06580 411154002077 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 411154002078 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 411154002079 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 411154002080 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 411154002081 dimerization interface [polypeptide binding]; other site 411154002082 metal binding site [ion binding]; metal-binding site 411154002083 cyanophycin synthetase; Provisional; Region: PRK14016 411154002084 ATP-grasp domain; Region: ATP-grasp_4; cl17255 411154002085 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 411154002086 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 411154002087 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 411154002088 proposed catalytic triad [active] 411154002089 active site nucleophile [active] 411154002090 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 411154002091 catalytic nucleophile [active] 411154002092 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 411154002093 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 411154002094 diaminopimelate decarboxylase; Region: lysA; TIGR01048 411154002095 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 411154002096 active site 411154002097 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 411154002098 substrate binding site [chemical binding]; other site 411154002099 catalytic residues [active] 411154002100 dimer interface [polypeptide binding]; other site 411154002101 MFS transport protein AraJ; Provisional; Region: PRK10091 411154002102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154002103 putative substrate translocation pore; other site 411154002104 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 411154002105 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 411154002106 CoA-ligase; Region: Ligase_CoA; pfam00549 411154002107 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 411154002108 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 411154002109 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 411154002110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 411154002111 Coenzyme A binding pocket [chemical binding]; other site 411154002112 trehalase; Provisional; Region: treF; PRK13270 411154002113 Trehalase; Region: Trehalase; cl17346 411154002114 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 411154002115 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 411154002116 putative active site [active] 411154002117 putative metal binding site [ion binding]; other site 411154002118 imidazolonepropionase; Validated; Region: PRK09356 411154002119 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 411154002120 active site 411154002121 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 411154002122 pentamer interface [polypeptide binding]; other site 411154002123 dodecaamer interface [polypeptide binding]; other site 411154002124 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 411154002125 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 411154002126 putative NAD(P) binding site [chemical binding]; other site 411154002127 putative substrate binding site [chemical binding]; other site 411154002128 catalytic Zn binding site [ion binding]; other site 411154002129 structural Zn binding site [ion binding]; other site 411154002130 dimer interface [polypeptide binding]; other site 411154002131 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 411154002132 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 411154002133 homodimer interface [polypeptide binding]; other site 411154002134 substrate-cofactor binding pocket; other site 411154002135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154002136 catalytic residue [active] 411154002137 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 411154002138 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 411154002139 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 411154002140 homodimer interface [polypeptide binding]; other site 411154002141 metal binding site [ion binding]; metal-binding site 411154002142 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 411154002143 homodimer interface [polypeptide binding]; other site 411154002144 active site 411154002145 putative chemical substrate binding site [chemical binding]; other site 411154002146 metal binding site [ion binding]; metal-binding site 411154002147 Methyltransferase domain; Region: Methyltransf_23; pfam13489 411154002148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154002149 S-adenosylmethionine binding site [chemical binding]; other site 411154002150 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 411154002151 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 411154002152 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 411154002153 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 411154002154 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 411154002155 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 411154002156 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 411154002157 shikimate binding site; other site 411154002158 NAD(P) binding site [chemical binding]; other site 411154002159 Domain of unknown function (DUF368); Region: DUF368; pfam04018 411154002160 Domain of unknown function (DUF368); Region: DUF368; pfam04018 411154002161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 411154002162 TPR repeat; Region: TPR_11; pfam13414 411154002163 binding surface 411154002164 TPR motif; other site 411154002165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154002166 binding surface 411154002167 TPR motif; other site 411154002168 TPR repeat; Region: TPR_11; pfam13414 411154002169 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154002170 binding surface 411154002171 TPR repeat; Region: TPR_11; pfam13414 411154002172 TPR motif; other site 411154002173 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154002174 TPR motif; other site 411154002175 TPR repeat; Region: TPR_11; pfam13414 411154002176 binding surface 411154002177 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 411154002178 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 411154002179 inhibitor-cofactor binding pocket; inhibition site 411154002180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154002181 catalytic residue [active] 411154002182 OstA-like protein; Region: OstA_2; pfam13100 411154002183 Ferritin-like domain; Region: Ferritin_2; pfam13668 411154002184 Ferritin-like domain; Region: Ferritin_2; pfam13668 411154002185 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 411154002186 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 411154002187 GDP-binding site [chemical binding]; other site 411154002188 ACT binding site; other site 411154002189 IMP binding site; other site 411154002190 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 411154002191 metal binding site 2 [ion binding]; metal-binding site 411154002192 putative DNA binding helix; other site 411154002193 metal binding site 1 [ion binding]; metal-binding site 411154002194 dimer interface [polypeptide binding]; other site 411154002195 structural Zn2+ binding site [ion binding]; other site 411154002196 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 411154002197 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 411154002198 Zn2+ binding site [ion binding]; other site 411154002199 Mg2+ binding site [ion binding]; other site 411154002200 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 411154002201 synthetase active site [active] 411154002202 NTP binding site [chemical binding]; other site 411154002203 metal binding site [ion binding]; metal-binding site 411154002204 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 411154002205 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 411154002206 Peptidase family M48; Region: Peptidase_M48; pfam01435 411154002207 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 411154002208 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 411154002209 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 411154002210 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 411154002211 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 411154002212 Amidohydrolase; Region: Amidohydro_4; pfam13147 411154002213 active site 411154002214 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 411154002215 active site 411154002216 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 411154002217 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 411154002218 active site 411154002219 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 411154002220 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 411154002221 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 411154002222 metal binding site [ion binding]; metal-binding site 411154002223 dimer interface [polypeptide binding]; other site 411154002224 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 411154002225 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 411154002226 active site 411154002227 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 411154002228 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 411154002229 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 411154002230 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 411154002231 DHH family; Region: DHH; pfam01368 411154002232 DHHA1 domain; Region: DHHA1; pfam02272 411154002233 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 411154002234 putative active site [active] 411154002235 putative metal binding site [ion binding]; other site 411154002236 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 411154002237 active site 411154002238 multimer interface [polypeptide binding]; other site 411154002239 Protein of unknown function (DUF721); Region: DUF721; pfam05258 411154002240 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 411154002241 recombination protein F; Reviewed; Region: recF; PRK00064 411154002242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154002243 Walker A/P-loop; other site 411154002244 ATP binding site [chemical binding]; other site 411154002245 Q-loop/lid; other site 411154002246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154002247 ABC transporter signature motif; other site 411154002248 Walker B; other site 411154002249 D-loop; other site 411154002250 H-loop/switch region; other site 411154002251 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 411154002252 homopentamer interface [polypeptide binding]; other site 411154002253 active site 411154002254 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 411154002255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154002256 ATP binding site [chemical binding]; other site 411154002257 Mg2+ binding site [ion binding]; other site 411154002258 G-X-G motif; other site 411154002259 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 411154002260 ATP binding site [chemical binding]; other site 411154002261 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 411154002262 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 411154002263 Rhomboid family; Region: Rhomboid; pfam01694 411154002264 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 411154002265 putative catalytic site [active] 411154002266 putative metal binding site [ion binding]; other site 411154002267 putative phosphate binding site [ion binding]; other site 411154002268 WbqC-like protein family; Region: WbqC; pfam08889 411154002269 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 411154002270 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 411154002271 Catalytic site [active] 411154002272 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 411154002273 dihydrodipicolinate reductase; Provisional; Region: PRK00048 411154002274 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 411154002275 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 411154002276 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 411154002277 ParB-like nuclease domain; Region: ParBc; pfam02195 411154002278 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 411154002279 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 411154002280 P-loop; other site 411154002281 Magnesium ion binding site [ion binding]; other site 411154002282 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 411154002283 Magnesium ion binding site [ion binding]; other site 411154002284 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 411154002285 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 411154002286 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 411154002287 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 411154002288 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 411154002289 short chain dehydrogenase; Provisional; Region: PRK07677 411154002290 NAD(P) binding site [chemical binding]; other site 411154002291 substrate binding site [chemical binding]; other site 411154002292 homotetramer interface [polypeptide binding]; other site 411154002293 active site 411154002294 homodimer interface [polypeptide binding]; other site 411154002295 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 411154002296 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 411154002297 active site 411154002298 substrate binding site [chemical binding]; other site 411154002299 coenzyme B12 binding site [chemical binding]; other site 411154002300 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 411154002301 B12 binding site [chemical binding]; other site 411154002302 cobalt ligand [ion binding]; other site 411154002303 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 411154002304 heterodimer interface [polypeptide binding]; other site 411154002305 substrate interaction site [chemical binding]; other site 411154002306 Septum formation initiator; Region: DivIC; pfam04977 411154002307 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 411154002308 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 411154002309 ATP-binding site [chemical binding]; other site 411154002310 Sugar specificity; other site 411154002311 Pyrimidine base specificity; other site 411154002312 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 411154002313 Cytochrome c; Region: Cytochrom_C; pfam00034 411154002314 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 411154002315 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 411154002316 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 411154002317 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 411154002318 TrkA-C domain; Region: TrkA_C; pfam02080 411154002319 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 411154002320 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 411154002321 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 411154002322 short chain dehydrogenase; Validated; Region: PRK08264 411154002323 classical (c) SDR, subgroup 7; Region: SDR_c7; cd05354 411154002324 putative NAD(P) binding site [chemical binding]; other site 411154002325 active site 411154002326 EthD domain; Region: EthD; cl17553 411154002327 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 411154002328 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 411154002329 catalytic residues [active] 411154002330 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 411154002331 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 411154002332 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 411154002333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154002334 active site 411154002335 phosphorylation site [posttranslational modification] 411154002336 intermolecular recognition site; other site 411154002337 dimerization interface [polypeptide binding]; other site 411154002338 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 411154002339 DNA binding site [nucleotide binding] 411154002340 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 411154002341 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 411154002342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154002343 ATP binding site [chemical binding]; other site 411154002344 Mg2+ binding site [ion binding]; other site 411154002345 G-X-G motif; other site 411154002346 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 411154002347 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 411154002348 SdiA-regulated; Region: SdiA-regulated; cd09971 411154002349 putative active site [active] 411154002350 Uncharacterized conserved protein [Function unknown]; Region: COG0398 411154002351 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 411154002352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 411154002353 non-specific DNA binding site [nucleotide binding]; other site 411154002354 salt bridge; other site 411154002355 sequence-specific DNA binding site [nucleotide binding]; other site 411154002356 Sulfatase; Region: Sulfatase; cl17466 411154002357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154002358 binding surface 411154002359 TPR motif; other site 411154002360 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 411154002361 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 411154002362 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 411154002363 DXD motif; other site 411154002364 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 411154002365 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 411154002366 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 411154002367 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 411154002368 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 411154002369 active site 411154002370 catalytic tetrad [active] 411154002371 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 411154002372 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 411154002373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154002374 active site 411154002375 phosphorylation site [posttranslational modification] 411154002376 intermolecular recognition site; other site 411154002377 dimerization interface [polypeptide binding]; other site 411154002378 LytTr DNA-binding domain; Region: LytTR; smart00850 411154002379 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 411154002380 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 411154002381 DXD motif; other site 411154002382 HEAT repeats; Region: HEAT_2; pfam13646 411154002383 Response regulator receiver domain; Region: Response_reg; pfam00072 411154002384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154002385 active site 411154002386 phosphorylation site [posttranslational modification] 411154002387 intermolecular recognition site; other site 411154002388 dimerization interface [polypeptide binding]; other site 411154002389 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 411154002390 PAS domain S-box; Region: sensory_box; TIGR00229 411154002391 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 411154002392 putative active site [active] 411154002393 heme pocket [chemical binding]; other site 411154002394 PAS domain S-box; Region: sensory_box; TIGR00229 411154002395 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 411154002396 putative active site [active] 411154002397 heme pocket [chemical binding]; other site 411154002398 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 411154002399 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 411154002400 putative active site [active] 411154002401 heme pocket [chemical binding]; other site 411154002402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154002403 dimer interface [polypeptide binding]; other site 411154002404 phosphorylation site [posttranslational modification] 411154002405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154002406 ATP binding site [chemical binding]; other site 411154002407 Mg2+ binding site [ion binding]; other site 411154002408 G-X-G motif; other site 411154002409 Response regulator receiver domain; Region: Response_reg; pfam00072 411154002410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154002411 active site 411154002412 phosphorylation site [posttranslational modification] 411154002413 intermolecular recognition site; other site 411154002414 dimerization interface [polypeptide binding]; other site 411154002415 Response regulator receiver domain; Region: Response_reg; pfam00072 411154002416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154002417 active site 411154002418 phosphorylation site [posttranslational modification] 411154002419 intermolecular recognition site; other site 411154002420 dimerization interface [polypeptide binding]; other site 411154002421 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 411154002422 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 411154002423 dimer interface [polypeptide binding]; other site 411154002424 ligand binding site [chemical binding]; other site 411154002425 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 411154002426 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 411154002427 dimer interface [polypeptide binding]; other site 411154002428 active site 411154002429 heme binding site [chemical binding]; other site 411154002430 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 411154002431 proline aminopeptidase P II; Provisional; Region: PRK10879 411154002432 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 411154002433 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 411154002434 active site 411154002435 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 411154002436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 411154002437 ACT domain; Region: ACT_3; pfam10000 411154002438 Family description; Region: ACT_7; pfam13840 411154002439 Transposase; Region: DEDD_Tnp_IS110; pfam01548 411154002440 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 411154002441 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 411154002442 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 411154002443 Predicted esterase [General function prediction only]; Region: COG0400 411154002444 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 411154002445 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 411154002446 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 411154002447 catalytic motif [active] 411154002448 Catalytic residue [active] 411154002449 Transposase; Region: DEDD_Tnp_IS110; pfam01548 411154002450 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 411154002451 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 411154002452 Divergent AAA domain; Region: AAA_4; pfam04326 411154002453 putative transposase OrfB; Reviewed; Region: PHA02517 411154002454 HTH-like domain; Region: HTH_21; pfam13276 411154002455 Integrase core domain; Region: rve; pfam00665 411154002456 Integrase core domain; Region: rve_3; pfam13683 411154002457 DNA methylase; Region: N6_N4_Mtase; cl17433 411154002458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 411154002459 non-specific DNA binding site [nucleotide binding]; other site 411154002460 salt bridge; other site 411154002461 sequence-specific DNA binding site [nucleotide binding]; other site 411154002462 Fic family protein [Function unknown]; Region: COG3177 411154002463 Fic/DOC family; Region: Fic; pfam02661 411154002464 Restriction endonuclease; Region: Mrr_cat; pfam04471 411154002465 Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903 411154002466 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 411154002467 active site 411154002468 Transposase; Region: DEDD_Tnp_IS110; pfam01548 411154002469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 411154002470 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 411154002471 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 411154002472 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154002473 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 411154002474 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 411154002475 non-specific DNA binding site [nucleotide binding]; other site 411154002476 salt bridge; other site 411154002477 sequence-specific DNA binding site [nucleotide binding]; other site 411154002478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154002479 binding surface 411154002480 TPR repeat; Region: TPR_11; pfam13414 411154002481 TPR motif; other site 411154002482 Homeodomain-like domain; Region: HTH_23; cl17451 411154002483 putative transposase OrfB; Reviewed; Region: PHA02517 411154002484 HTH-like domain; Region: HTH_21; pfam13276 411154002485 Integrase core domain; Region: rve; pfam00665 411154002486 Integrase core domain; Region: rve_3; pfam13683 411154002487 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 411154002488 PLD-like domain; Region: PLDc_2; pfam13091 411154002489 putative homodimer interface [polypeptide binding]; other site 411154002490 putative active site [active] 411154002491 catalytic site [active] 411154002492 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 411154002493 Transposase; Region: DEDD_Tnp_IS110; pfam01548 411154002494 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 411154002495 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 411154002496 Erythromycin esterase; Region: Erythro_esteras; pfam05139 411154002497 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 411154002498 Transposase; Region: DEDD_Tnp_IS110; pfam01548 411154002499 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 411154002500 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 411154002501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 411154002502 non-specific DNA binding site [nucleotide binding]; other site 411154002503 salt bridge; other site 411154002504 sequence-specific DNA binding site [nucleotide binding]; other site 411154002505 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 411154002506 Transposase; Region: DEDD_Tnp_IS110; pfam01548 411154002507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 411154002508 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 411154002509 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 411154002510 ATP-grasp domain; Region: ATP-grasp_4; cl17255 411154002511 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 411154002512 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 411154002513 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 411154002514 catalytic residues [active] 411154002515 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 411154002516 Transposase; Region: DEDD_Tnp_IS110; pfam01548 411154002517 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 411154002518 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 411154002519 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 411154002520 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 411154002521 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 411154002522 Pathogenicity locus; Region: Cdd1; pfam11731 411154002523 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 411154002524 active site 411154002525 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 411154002526 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 411154002527 Transposase; Region: DEDD_Tnp_IS110; pfam01548 411154002528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 411154002529 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 411154002530 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 411154002531 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 411154002532 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 411154002533 non-specific DNA binding site [nucleotide binding]; other site 411154002534 salt bridge; other site 411154002535 sequence-specific DNA binding site [nucleotide binding]; other site 411154002536 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 411154002537 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cd00489 411154002538 RNAase interaction site [polypeptide binding]; other site 411154002539 integron integrase; Region: integrase_gron; TIGR02249 411154002540 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 411154002541 active site 411154002542 DNA binding site [nucleotide binding] 411154002543 Int/Topo IB signature motif; other site 411154002544 tellurium resistance terB-like protein; Region: terB_like; cd07177 411154002545 metal binding site [ion binding]; metal-binding site 411154002546 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 411154002547 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 411154002548 NAD(P) binding site [chemical binding]; other site 411154002549 catalytic residues [active] 411154002550 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 411154002551 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 411154002552 ligand binding site [chemical binding]; other site 411154002553 flexible hinge region; other site 411154002554 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 411154002555 putative switch regulator; other site 411154002556 non-specific DNA interactions [nucleotide binding]; other site 411154002557 DNA binding site [nucleotide binding] 411154002558 sequence specific DNA binding site [nucleotide binding]; other site 411154002559 putative cAMP binding site [chemical binding]; other site 411154002560 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 411154002561 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 411154002562 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 411154002563 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 411154002564 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 411154002565 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 411154002566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154002567 S-adenosylmethionine binding site [chemical binding]; other site 411154002568 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 411154002569 human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs; Region: 17beta-HSDXI-like_SDR_c; cd05339 411154002570 putative NAD(P) binding site [chemical binding]; other site 411154002571 homodimer interface [polypeptide binding]; other site 411154002572 active site 411154002573 substrate binding site [chemical binding]; other site 411154002574 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 411154002575 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 411154002576 NAD(P) binding site [chemical binding]; other site 411154002577 catalytic residues [active] 411154002578 Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144 411154002579 putative FMN binding site [chemical binding]; other site 411154002580 putative dimer interface [polypeptide binding]; other site 411154002581 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 411154002582 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 411154002583 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 411154002584 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 411154002585 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 411154002586 active site residue [active] 411154002587 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 411154002588 carboxyltransferase (CT) interaction site; other site 411154002589 biotinylation site [posttranslational modification]; other site 411154002590 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 411154002591 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 411154002592 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 411154002593 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 411154002594 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 411154002595 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 411154002596 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 411154002597 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_9; cd12170 411154002598 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 411154002599 putative ligand binding site [chemical binding]; other site 411154002600 putative NAD binding site [chemical binding]; other site 411154002601 Predicted transporter component [General function prediction only]; Region: COG2391 411154002602 Sulphur transport; Region: Sulf_transp; pfam04143 411154002603 Cupin domain; Region: Cupin_2; cl17218 411154002604 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02986 411154002605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 411154002606 NAD(P) binding site [chemical binding]; other site 411154002607 active site 411154002608 SnoaL-like domain; Region: SnoaL_2; pfam12680 411154002609 cheY-homologous receiver domain; Region: REC; smart00448 411154002610 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 411154002611 active site 411154002612 phosphorylation site [posttranslational modification] 411154002613 intermolecular recognition site; other site 411154002614 LytTr DNA-binding domain; Region: LytTR; smart00850 411154002615 Predicted membrane protein [Function unknown]; Region: COG2860 411154002616 UPF0126 domain; Region: UPF0126; pfam03458 411154002617 UPF0126 domain; Region: UPF0126; pfam03458 411154002618 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 411154002619 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 411154002620 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 411154002621 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 411154002622 PspC domain; Region: PspC; pfam04024 411154002623 Predicted transcriptional regulators [Transcription]; Region: COG1695 411154002624 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 411154002625 putative Zn2+ binding site [ion binding]; other site 411154002626 putative DNA binding site [nucleotide binding]; other site 411154002627 Tic20-like protein; Region: Tic20; pfam09685 411154002628 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 411154002629 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 411154002630 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 411154002631 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 411154002632 dimerization interface [polypeptide binding]; other site 411154002633 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 411154002634 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 411154002635 Protein of unknown function DUF58; Region: DUF58; pfam01882 411154002636 MoxR-like ATPases [General function prediction only]; Region: COG0714 411154002637 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154002638 Walker A motif; other site 411154002639 ATP binding site [chemical binding]; other site 411154002640 Walker B motif; other site 411154002641 arginine finger; other site 411154002642 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 411154002643 Integral membrane protein DUF95; Region: DUF95; pfam01944 411154002644 RDD family; Region: RDD; pfam06271 411154002645 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 411154002646 active site 411154002647 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 411154002648 putative active site [active] 411154002649 putative CoA binding site [chemical binding]; other site 411154002650 nudix motif; other site 411154002651 metal binding site [ion binding]; metal-binding site 411154002652 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 411154002653 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 411154002654 putative acyl-acceptor binding pocket; other site 411154002655 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 411154002656 agmatinase; Region: agmatinase; TIGR01230 411154002657 putative active site [active] 411154002658 Mn binding site [ion binding]; other site 411154002659 Transposase, Mutator family; Region: Transposase_mut; pfam00872 411154002660 MULE transposase domain; Region: MULE; pfam10551 411154002661 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 411154002662 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 411154002663 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 411154002664 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 411154002665 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 411154002666 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 411154002667 Hemerythrin-like domain; Region: Hr-like; cd12108 411154002668 Histidine kinase; Region: His_kinase; pfam06580 411154002669 2TM domain; Region: 2TM; pfam13239 411154002670 2TM domain; Region: 2TM; pfam13239 411154002671 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 411154002672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154002673 active site 411154002674 phosphorylation site [posttranslational modification] 411154002675 intermolecular recognition site; other site 411154002676 dimerization interface [polypeptide binding]; other site 411154002677 LytTr DNA-binding domain; Region: LytTR; smart00850 411154002678 putative anti-sigmaE protein; Provisional; Region: PRK13920 411154002679 Anti-sigma-K factor rskA; Region: RskA; pfam10099 411154002680 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 411154002681 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 411154002682 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 411154002683 DNA binding residues [nucleotide binding] 411154002684 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 411154002685 E-class dimer interface [polypeptide binding]; other site 411154002686 P-class dimer interface [polypeptide binding]; other site 411154002687 active site 411154002688 Cu2+ binding site [ion binding]; other site 411154002689 Zn2+ binding site [ion binding]; other site 411154002690 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 411154002691 PGAP1-like protein; Region: PGAP1; pfam07819 411154002692 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 411154002693 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 411154002694 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 411154002695 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 411154002696 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 411154002697 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 411154002698 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 411154002699 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 411154002700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154002701 putative substrate translocation pore; other site 411154002702 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 411154002703 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 411154002704 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 411154002705 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 411154002706 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 411154002707 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 411154002708 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 411154002709 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154002710 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 411154002711 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154002712 starch binding outer membrane protein SusD; Region: SusD; cd08977 411154002713 SusD family; Region: SusD; pfam07980 411154002714 Family description; Region: VCBS; pfam13517 411154002715 Family description; Region: VCBS; pfam13517 411154002716 Family description; Region: VCBS; pfam13517 411154002717 Family description; Region: VCBS; pfam13517 411154002718 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 411154002719 Family description; Region: VCBS; pfam13517 411154002720 Family description; Region: VCBS; pfam13517 411154002721 Family description; Region: VCBS; pfam13517 411154002722 Family description; Region: VCBS; pfam13517 411154002723 Family description; Region: VCBS; pfam13517 411154002724 Family description; Region: VCBS; pfam13517 411154002725 Family description; Region: VCBS; pfam13517 411154002726 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 411154002727 Family description; Region: VCBS; pfam13517 411154002728 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 411154002729 active site 411154002730 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 411154002731 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 411154002732 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 411154002733 Uncharacterized conserved protein [Function unknown]; Region: COG4850 411154002734 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 411154002735 transcription termination factor Rho; Provisional; Region: PRK12678 411154002736 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 411154002737 putative metal binding site [ion binding]; other site 411154002738 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 411154002739 Interdomain contacts; other site 411154002740 YtxH-like protein; Region: YtxH; cl02079 411154002741 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 411154002742 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 411154002743 active site 411154002744 homotetramer interface [polypeptide binding]; other site 411154002745 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 411154002746 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 411154002747 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 411154002748 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 411154002749 active site 411154002750 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 411154002751 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 411154002752 active site 411154002753 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 411154002754 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 411154002755 dimer interface [polypeptide binding]; other site 411154002756 active site 411154002757 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 411154002758 four helix bundle protein; Region: TIGR02436 411154002759 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 411154002760 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 411154002761 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 411154002762 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 411154002763 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 411154002764 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 411154002765 substrate binding site [chemical binding]; other site 411154002766 oxyanion hole (OAH) forming residues; other site 411154002767 trimer interface [polypeptide binding]; other site 411154002768 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 411154002769 MarR family; Region: MarR; pfam01047 411154002770 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 411154002771 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 411154002772 acyl-activating enzyme (AAE) consensus motif; other site 411154002773 putative AMP binding site [chemical binding]; other site 411154002774 putative active site [active] 411154002775 putative CoA binding site [chemical binding]; other site 411154002776 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 411154002777 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 411154002778 dimerization interface [polypeptide binding]; other site 411154002779 ATP binding site [chemical binding]; other site 411154002780 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 411154002781 dimerization interface [polypeptide binding]; other site 411154002782 ATP binding site [chemical binding]; other site 411154002783 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 411154002784 putative active site [active] 411154002785 catalytic triad [active] 411154002786 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 411154002787 16S rRNA methyltransferase B; Provisional; Region: PRK14902 411154002788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154002789 S-adenosylmethionine binding site [chemical binding]; other site 411154002790 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 411154002791 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 411154002792 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 411154002793 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 411154002794 DNA binding residues [nucleotide binding] 411154002795 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 411154002796 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 411154002797 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 411154002798 Walker A/P-loop; other site 411154002799 ATP binding site [chemical binding]; other site 411154002800 Q-loop/lid; other site 411154002801 ABC transporter signature motif; other site 411154002802 Walker B; other site 411154002803 D-loop; other site 411154002804 H-loop/switch region; other site 411154002805 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 411154002806 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 411154002807 active site 411154002808 substrate binding site [chemical binding]; other site 411154002809 metal binding site [ion binding]; metal-binding site 411154002810 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 411154002811 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 411154002812 Ligand binding site; other site 411154002813 Putative Catalytic site; other site 411154002814 DXD motif; other site 411154002815 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 411154002816 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 411154002817 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 411154002818 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 411154002819 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 411154002820 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 411154002821 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 411154002822 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 411154002823 Pirin; Region: Pirin; pfam02678 411154002824 Pirin-related protein [General function prediction only]; Region: COG1741 411154002825 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 411154002826 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 411154002827 N-acetyl-D-glucosamine binding site [chemical binding]; other site 411154002828 catalytic residue [active] 411154002829 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 411154002830 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 411154002831 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 411154002832 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 411154002833 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 411154002834 ATP-grasp domain; Region: ATP-grasp_4; cl17255 411154002835 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 411154002836 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 411154002837 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 411154002838 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 411154002839 ATP-grasp domain; Region: ATP-grasp_4; cl17255 411154002840 Protein of unknown function (DUF423); Region: DUF423; pfam04241 411154002841 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 411154002842 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 411154002843 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 411154002844 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 411154002845 Beta-lactamase; Region: Beta-lactamase; pfam00144 411154002846 DNA recombination protein RmuC; Provisional; Region: PRK10361 411154002847 RmuC family; Region: RmuC; pfam02646 411154002848 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 411154002849 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 411154002850 Walker A/P-loop; other site 411154002851 ATP binding site [chemical binding]; other site 411154002852 Q-loop/lid; other site 411154002853 ABC transporter signature motif; other site 411154002854 Walker B; other site 411154002855 D-loop; other site 411154002856 H-loop/switch region; other site 411154002857 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 411154002858 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 411154002859 ABC-ATPase subunit interface; other site 411154002860 dimer interface [polypeptide binding]; other site 411154002861 putative PBP binding regions; other site 411154002862 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 411154002863 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 411154002864 putative ligand binding site [chemical binding]; other site 411154002865 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154002866 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 411154002867 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 411154002868 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 411154002869 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 411154002870 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 411154002871 Catalytic dyad [active] 411154002872 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 411154002873 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 411154002874 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 411154002875 DNA binding residues [nucleotide binding] 411154002876 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 411154002877 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 411154002878 adenylosuccinate lyase; Provisional; Region: PRK09285 411154002879 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 411154002880 tetramer interface [polypeptide binding]; other site 411154002881 active site 411154002882 NAD-dependent deacetylase; Provisional; Region: PRK00481 411154002883 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 411154002884 NAD+ binding site [chemical binding]; other site 411154002885 substrate binding site [chemical binding]; other site 411154002886 Zn binding site [ion binding]; other site 411154002887 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 411154002888 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 411154002889 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 411154002890 putative hydrophobic ligand binding site [chemical binding]; other site 411154002891 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154002892 helicase 45; Provisional; Region: PTZ00424 411154002893 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 411154002894 ATP binding site [chemical binding]; other site 411154002895 Mg++ binding site [ion binding]; other site 411154002896 motif III; other site 411154002897 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 411154002898 nucleotide binding region [chemical binding]; other site 411154002899 ATP-binding site [chemical binding]; other site 411154002900 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 411154002901 RNA binding site [nucleotide binding]; other site 411154002902 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 411154002903 active site 411154002904 dimerization interface [polypeptide binding]; other site 411154002905 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 411154002906 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 411154002907 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 411154002908 dimerization interface [polypeptide binding]; other site 411154002909 active site 411154002910 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 411154002911 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 411154002912 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 411154002913 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 411154002914 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 411154002915 ATP binding site [chemical binding]; other site 411154002916 putative Mg++ binding site [ion binding]; other site 411154002917 helicase superfamily c-terminal domain; Region: HELICc; smart00490 411154002918 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 411154002919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154002920 active site 411154002921 phosphorylation site [posttranslational modification] 411154002922 intermolecular recognition site; other site 411154002923 dimerization interface [polypeptide binding]; other site 411154002924 LytTr DNA-binding domain; Region: LytTR; smart00850 411154002925 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 411154002926 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 411154002927 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 411154002928 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 411154002929 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 411154002930 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 411154002931 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 411154002932 FtsX-like permease family; Region: FtsX; pfam02687 411154002933 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 411154002934 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 411154002935 dimer interface [polypeptide binding]; other site 411154002936 motif 1; other site 411154002937 active site 411154002938 motif 2; other site 411154002939 motif 3; other site 411154002940 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 411154002941 anticodon binding site; other site 411154002942 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 411154002943 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 411154002944 active site 411154002945 catalytic tetrad [active] 411154002946 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 411154002947 Domain of unknown function DUF302; Region: DUF302; pfam03625 411154002948 DoxX; Region: DoxX; pfam07681 411154002949 DsrE/DsrF-like family; Region: DrsE; pfam02635 411154002950 Outer membrane efflux protein; Region: OEP; pfam02321 411154002951 Outer membrane efflux protein; Region: OEP; pfam02321 411154002952 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 411154002953 HlyD family secretion protein; Region: HlyD_3; pfam13437 411154002954 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 411154002955 four helix bundle protein; Region: TIGR02436 411154002956 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 411154002957 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 411154002958 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 411154002959 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 411154002960 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 411154002961 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 411154002962 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 411154002963 MerT mercuric transport protein; Region: MerT; cl03578 411154002964 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 411154002965 metal-binding site [ion binding] 411154002966 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 411154002967 dimerization interface [polypeptide binding]; other site 411154002968 putative DNA binding site [nucleotide binding]; other site 411154002969 putative Zn2+ binding site [ion binding]; other site 411154002970 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 411154002971 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 411154002972 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 411154002973 ligand binding site [chemical binding]; other site 411154002974 flexible hinge region; other site 411154002975 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 411154002976 YceI-like domain; Region: YceI; cl01001 411154002977 YceI-like domain; Region: YceI; cl01001 411154002978 Pirin-related protein [General function prediction only]; Region: COG1741 411154002979 Pirin; Region: Pirin; pfam02678 411154002980 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 411154002981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 411154002982 Coenzyme A binding pocket [chemical binding]; other site 411154002983 Pirin-related protein [General function prediction only]; Region: COG1741 411154002984 Pirin; Region: Pirin; pfam02678 411154002985 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 411154002986 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 411154002987 Alginate lyase; Region: Alginate_lyase2; pfam08787 411154002988 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 411154002989 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 411154002990 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 411154002991 Metal-binding active site; metal-binding site 411154002992 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 411154002993 Alginate lyase; Region: Alginate_lyase2; pfam08787 411154002994 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 411154002995 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 411154002996 Cupin domain; Region: Cupin_2; pfam07883 411154002997 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154002998 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 411154002999 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 411154003000 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 411154003001 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 411154003002 starch binding outer membrane protein SusD; Region: SusD; cd08977 411154003003 FOG: PKD repeat [General function prediction only]; Region: COG3291 411154003004 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 411154003005 Alginate lyase; Region: Alginate_lyase2; pfam08787 411154003006 Alginate lyase; Region: Alginate_lyase2; pfam08787 411154003007 transcriptional regulator NanR; Provisional; Region: PRK03837 411154003008 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 411154003009 DNA-binding site [nucleotide binding]; DNA binding site 411154003010 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 411154003011 D-galactonate transporter; Region: 2A0114; TIGR00893 411154003012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154003013 putative substrate translocation pore; other site 411154003014 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 411154003015 classical (c) SDRs; Region: SDR_c; cd05233 411154003016 NAD(P) binding site [chemical binding]; other site 411154003017 active site 411154003018 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 411154003019 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 411154003020 substrate binding site [chemical binding]; other site 411154003021 ATP binding site [chemical binding]; other site 411154003022 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 411154003023 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 411154003024 active site 411154003025 intersubunit interface [polypeptide binding]; other site 411154003026 catalytic residue [active] 411154003027 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 411154003028 AMP binding site [chemical binding]; other site 411154003029 metal binding site [ion binding]; metal-binding site 411154003030 active site 411154003031 Transcriptional regulators [Transcription]; Region: PurR; COG1609 411154003032 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 411154003033 DNA binding site [nucleotide binding] 411154003034 domain linker motif; other site 411154003035 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 411154003036 dimerization interface [polypeptide binding]; other site 411154003037 ligand binding site [chemical binding]; other site 411154003038 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 411154003039 active site 411154003040 catalytic residues [active] 411154003041 DNA binding site [nucleotide binding] 411154003042 Int/Topo IB signature motif; other site 411154003043 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 411154003044 Domain of unknown function (DUF305); Region: DUF305; cl17794 411154003045 Transposase IS200 like; Region: Y1_Tnp; pfam01797 411154003046 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 411154003047 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 411154003048 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 411154003049 Multicopper oxidase; Region: Cu-oxidase; pfam00394 411154003050 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 411154003051 Domain of unknown function DUF302; Region: DUF302; cl01364 411154003052 Ion channel; Region: Ion_trans_2; pfam07885 411154003053 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 411154003054 dimerization interface [polypeptide binding]; other site 411154003055 Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919 411154003056 putative active site [active] 411154003057 redox center [active] 411154003058 Trehalase; Region: Trehalase; cl17346 411154003059 short chain dehydrogenase; Provisional; Region: PRK07109 411154003060 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 411154003061 putative NAD(P) binding site [chemical binding]; other site 411154003062 active site 411154003063 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 411154003064 metal-binding site [ion binding] 411154003065 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 411154003066 metal-binding site [ion binding] 411154003067 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 411154003068 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 411154003069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 411154003070 motif II; other site 411154003071 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 411154003072 Outer membrane efflux protein; Region: OEP; pfam02321 411154003073 Outer membrane efflux protein; Region: OEP; pfam02321 411154003074 HlyD family secretion protein; Region: HlyD_2; pfam12700 411154003075 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 411154003076 HlyD family secretion protein; Region: HlyD_3; pfam13437 411154003077 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 411154003078 Nitrogen regulatory protein P-II; Region: P-II; smart00938 411154003079 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 411154003080 putative DNA binding helix; other site 411154003081 metal binding site 2 [ion binding]; metal-binding site 411154003082 metal binding site 1 [ion binding]; metal-binding site 411154003083 dimer interface [polypeptide binding]; other site 411154003084 structural Zn2+ binding site [ion binding]; other site 411154003085 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 411154003086 Short C-terminal domain; Region: SHOCT; pfam09851 411154003087 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 411154003088 Predicted membrane protein [Function unknown]; Region: COG3462 411154003089 Divergent AAA domain; Region: AAA_4; pfam04326 411154003090 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 411154003091 MgtC family; Region: MgtC; pfam02308 411154003092 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 411154003093 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 411154003094 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 411154003095 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 411154003096 putative DNA binding helix; other site 411154003097 metal binding site 2 [ion binding]; metal-binding site 411154003098 metal binding site 1 [ion binding]; metal-binding site 411154003099 dimer interface [polypeptide binding]; other site 411154003100 structural Zn2+ binding site [ion binding]; other site 411154003101 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 411154003102 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 411154003103 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 411154003104 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 411154003105 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 411154003106 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 411154003107 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 411154003108 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 411154003109 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 411154003110 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 411154003111 amino acid transporter; Region: 2A0306; TIGR00909 411154003112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 411154003113 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 411154003114 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 411154003115 Ligand Binding Site [chemical binding]; other site 411154003116 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 411154003117 active site 411154003118 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 411154003119 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 411154003120 active site 411154003121 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 411154003122 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 411154003123 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 411154003124 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 411154003125 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 411154003126 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 411154003127 Ligand binding site; other site 411154003128 Putative Catalytic site; other site 411154003129 DXD motif; other site 411154003130 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 411154003131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 411154003132 NAD(P) binding site [chemical binding]; other site 411154003133 active site 411154003134 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 411154003135 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 411154003136 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 411154003137 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 411154003138 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 411154003139 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154003140 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154003141 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 411154003142 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 411154003143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154003144 dimer interface [polypeptide binding]; other site 411154003145 phosphorylation site [posttranslational modification] 411154003146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154003147 ATP binding site [chemical binding]; other site 411154003148 Mg2+ binding site [ion binding]; other site 411154003149 G-X-G motif; other site 411154003150 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 411154003151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154003152 active site 411154003153 phosphorylation site [posttranslational modification] 411154003154 intermolecular recognition site; other site 411154003155 dimerization interface [polypeptide binding]; other site 411154003156 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 411154003157 DNA binding site [nucleotide binding] 411154003158 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 411154003159 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 411154003160 active site 411154003161 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 411154003162 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 411154003163 dimer interface [polypeptide binding]; other site 411154003164 ssDNA binding site [nucleotide binding]; other site 411154003165 tetramer (dimer of dimers) interface [polypeptide binding]; other site 411154003166 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 411154003167 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 411154003168 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 411154003169 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 411154003170 Int/Topo IB signature motif; other site 411154003171 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 411154003172 active site 411154003173 DNA binding site [nucleotide binding] 411154003174 Int/Topo IB signature motif; other site 411154003175 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 411154003176 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 411154003177 active site 411154003178 DNA binding site [nucleotide binding] 411154003179 Int/Topo IB signature motif; other site 411154003180 RadC-like JAB domain; Region: RadC; pfam04002 411154003181 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 411154003182 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 411154003183 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 411154003184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 411154003185 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 411154003186 Domain of unknown function (DUF305); Region: DUF305; cl17794 411154003187 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 411154003188 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 411154003189 Multicopper oxidase; Region: Cu-oxidase; pfam00394 411154003190 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 411154003191 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 411154003192 Haem-binding domain; Region: Haem_bd; pfam14376 411154003193 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 411154003194 active site 411154003195 FMN binding site [chemical binding]; other site 411154003196 substrate binding site [chemical binding]; other site 411154003197 3Fe-4S cluster binding site [ion binding]; other site 411154003198 Ion channel; Region: Ion_trans_2; pfam07885 411154003199 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 411154003200 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 411154003201 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 411154003202 dimerization interface [polypeptide binding]; other site 411154003203 DNA binding residues [nucleotide binding] 411154003204 FecR protein; Region: FecR; pfam04773 411154003205 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 411154003206 Secretin and TonB N terminus short domain; Region: STN; pfam07660 411154003207 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 411154003208 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154003209 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154003210 starch binding outer membrane protein SusD; Region: SusD; cl17845 411154003211 starch binding outer membrane protein SusD; Region: SusD; cl17845 411154003212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154003213 Major Facilitator Superfamily; Region: MFS_1; pfam07690 411154003214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154003215 S-adenosylmethionine binding site [chemical binding]; other site 411154003216 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 411154003217 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 411154003218 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 411154003219 FecR protein; Region: FecR; pfam04773 411154003220 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 411154003221 Secretin and TonB N terminus short domain; Region: STN; pfam07660 411154003222 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 411154003223 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154003224 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 411154003225 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154003226 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 411154003227 starch binding outer membrane protein SusD; Region: SusD; cd08977 411154003228 SnoaL-like domain; Region: SnoaL_3; pfam13474 411154003229 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 411154003230 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 411154003231 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 411154003232 active site residue [active] 411154003233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154003234 S-adenosylmethionine binding site [chemical binding]; other site 411154003235 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 411154003236 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 411154003237 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 411154003238 active site residue [active] 411154003239 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 411154003240 Predicted transporter component [General function prediction only]; Region: COG2391 411154003241 Sulphur transport; Region: Sulf_transp; pfam04143 411154003242 Sulphur transport; Region: Sulf_transp; pfam04143 411154003243 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 411154003244 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 411154003245 ligand binding site [chemical binding]; other site 411154003246 flexible hinge region; other site 411154003247 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 411154003248 non-specific DNA interactions [nucleotide binding]; other site 411154003249 DNA binding site [nucleotide binding] 411154003250 sequence specific DNA binding site [nucleotide binding]; other site 411154003251 putative cAMP binding site [chemical binding]; other site 411154003252 DoxX; Region: DoxX; pfam07681 411154003253 DsrE/DsrF-like family; Region: DrsE; cl00672 411154003254 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 411154003255 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 411154003256 active site 411154003257 metal binding site [ion binding]; metal-binding site 411154003258 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 411154003259 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 411154003260 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 411154003261 catalytic residues [active] 411154003262 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 411154003263 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 411154003264 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 411154003265 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 411154003266 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 411154003267 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 411154003268 active site 411154003269 metal binding site [ion binding]; metal-binding site 411154003270 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 411154003271 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 411154003272 DsrE/DsrF-like family; Region: DrsE; pfam02635 411154003273 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 411154003274 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 411154003275 active site 411154003276 metal binding site [ion binding]; metal-binding site 411154003277 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 411154003278 Cytochrome c [Energy production and conversion]; Region: COG3258 411154003279 Cytochrome c [Energy production and conversion]; Region: COG3258 411154003280 Domain of unknown function DUF302; Region: DUF302; pfam03625 411154003281 Domain of unknown function DUF302; Region: DUF302; cl01364 411154003282 DoxX; Region: DoxX; pfam07681 411154003283 DsrE/DsrF-like family; Region: DrsE; pfam02635 411154003284 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 411154003285 Outer membrane efflux protein; Region: OEP; pfam02321 411154003286 Outer membrane efflux protein; Region: OEP; pfam02321 411154003287 HlyD family secretion protein; Region: HlyD_2; pfam12700 411154003288 HlyD family secretion protein; Region: HlyD_3; pfam13437 411154003289 H+ Antiporter protein; Region: 2A0121; TIGR00900 411154003290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154003291 putative substrate translocation pore; other site 411154003292 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 411154003293 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 411154003294 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 411154003295 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 411154003296 HlyD family secretion protein; Region: HlyD_3; pfam13437 411154003297 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 411154003298 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 411154003299 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 411154003300 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 411154003301 iron-sulfur cluster [ion binding]; other site 411154003302 [2Fe-2S] cluster binding site [ion binding]; other site 411154003303 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 411154003304 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 411154003305 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 411154003306 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154003307 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 411154003308 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 411154003309 N-terminal plug; other site 411154003310 ligand-binding site [chemical binding]; other site 411154003311 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 411154003312 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 411154003313 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 411154003314 DNA binding site [nucleotide binding] 411154003315 active site 411154003316 Int/Topo IB signature motif; other site 411154003317 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 411154003318 metal-binding site [ion binding] 411154003319 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 411154003320 Metal-sensitive transcriptional repressor; Region: Trns_repr_metal; pfam02583 411154003321 putative homotetramer interface [polypeptide binding]; other site 411154003322 putative homodimer interface [polypeptide binding]; other site 411154003323 Ligase N family; Region: LIGANc; smart00532 411154003324 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 411154003325 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 411154003326 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 411154003327 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 411154003328 MerT mercuric transport protein; Region: MerT; cl03578 411154003329 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 411154003330 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 411154003331 metal-binding site [ion binding] 411154003332 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 411154003333 dimerization interface [polypeptide binding]; other site 411154003334 putative DNA binding site [nucleotide binding]; other site 411154003335 putative Zn2+ binding site [ion binding]; other site 411154003336 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 411154003337 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 411154003338 dimer interface [polypeptide binding]; other site 411154003339 active site 411154003340 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 411154003341 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 411154003342 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 411154003343 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 411154003344 Outer membrane efflux protein; Region: OEP; pfam02321 411154003345 Outer membrane efflux protein; Region: OEP; pfam02321 411154003346 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 411154003347 HlyD family secretion protein; Region: HlyD_3; pfam13437 411154003348 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 411154003349 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 411154003350 Helix-turn-helix domain; Region: HTH_18; pfam12833 411154003351 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 411154003352 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 411154003353 Nitrogen regulatory protein P-II; Region: P-II; cl00412 411154003354 Nitrogen regulatory protein P-II; Region: P-II; smart00938 411154003355 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 411154003356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 411154003357 NAD(P) binding site [chemical binding]; other site 411154003358 active site 411154003359 Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919 411154003360 putative active site [active] 411154003361 redox center [active] 411154003362 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 411154003363 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 411154003364 Multicopper oxidase; Region: Cu-oxidase; pfam00394 411154003365 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 411154003366 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 411154003367 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 411154003368 Cu(I) binding site [ion binding]; other site 411154003369 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 411154003370 metal-binding site [ion binding] 411154003371 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 411154003372 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 411154003373 Soluble P-type ATPase [General function prediction only]; Region: COG4087 411154003374 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 411154003375 Bacterial PH domain; Region: DUF304; pfam03703 411154003376 Predicted membrane protein [Function unknown]; Region: COG3428 411154003377 Bacterial PH domain; Region: DUF304; pfam03703 411154003378 Bacterial PH domain; Region: DUF304; pfam03703 411154003379 Bacterial PH domain; Region: DUF304; pfam03703 411154003380 Putative phosphatase (DUF442); Region: DUF442; cl17385 411154003381 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 411154003382 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 411154003383 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 411154003384 active site residue [active] 411154003385 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 411154003386 active site residue [active] 411154003387 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 411154003388 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 411154003389 dimer interface [polypeptide binding]; other site 411154003390 ssDNA binding site [nucleotide binding]; other site 411154003391 tetramer (dimer of dimers) interface [polypeptide binding]; other site 411154003392 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 411154003393 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 411154003394 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 411154003395 active site 411154003396 DNA binding site [nucleotide binding] 411154003397 Int/Topo IB signature motif; other site 411154003398 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 411154003399 active site 411154003400 DNA binding site [nucleotide binding] 411154003401 Int/Topo IB signature motif; other site 411154003402 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 411154003403 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 411154003404 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 411154003405 Int/Topo IB signature motif; other site 411154003406 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 411154003407 ATP binding site [chemical binding]; other site 411154003408 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 411154003409 Walker B motif; other site 411154003410 Predicted transcriptional regulator [Transcription]; Region: COG5340 411154003411 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 411154003412 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 411154003413 Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780 411154003414 Domain of unknown function (DUF4138); Region: DUF4138; pfam13595 411154003415 Protein of unknown function (DUF3714); Region: DUF3714; pfam12508 411154003416 Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781 411154003417 Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783 411154003418 Domain of unknown function, B. Theta Gene description (DUF3875); Region: DUF3875; pfam12991 411154003419 Domain of unknown function DUF87; Region: DUF87; pfam01935 411154003420 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 411154003421 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 411154003422 active site 411154003423 metal binding site [ion binding]; metal-binding site 411154003424 RES domain; Region: RES; pfam08808 411154003425 Methyltransferase domain; Region: Methyltransf_26; pfam13659 411154003426 hypothetical protein; Validated; Region: PRK08116 411154003427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154003428 Walker A/P-loop; other site 411154003429 ATP binding site [chemical binding]; other site 411154003430 Helix-turn-helix domain; Region: HTH_17; pfam12728 411154003431 RteC protein; Region: RteC; pfam09357 411154003432 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 411154003433 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 411154003434 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 411154003435 catalytic residue [active] 411154003436 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 411154003437 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 411154003438 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 411154003439 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 411154003440 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 411154003441 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 411154003442 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 411154003443 starch binding outer membrane protein SusD; Region: SusD; cd08977 411154003444 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 411154003445 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 411154003446 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154003447 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 411154003448 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 411154003449 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 411154003450 non-specific DNA binding site [nucleotide binding]; other site 411154003451 salt bridge; other site 411154003452 sequence-specific DNA binding site [nucleotide binding]; other site 411154003453 Transposase; Region: HTH_Tnp_1; cl17663 411154003454 Integrase core domain; Region: rve; pfam00665 411154003455 Integrase core domain; Region: rve_3; pfam13683 411154003456 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 411154003457 aconitate hydratase; Validated; Region: PRK09277 411154003458 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 411154003459 substrate binding site [chemical binding]; other site 411154003460 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 411154003461 ligand binding site [chemical binding]; other site 411154003462 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 411154003463 substrate binding site [chemical binding]; other site 411154003464 Uncharacterized conserved protein [Function unknown]; Region: COG3189 411154003465 Cupin domain; Region: Cupin_2; cl17218 411154003466 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 411154003467 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 411154003468 heme-binding site [chemical binding]; other site 411154003469 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 411154003470 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 411154003471 Cytochrome c; Region: Cytochrom_C; pfam00034 411154003472 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 411154003473 Low-spin heme binding site [chemical binding]; other site 411154003474 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 411154003475 D-pathway; other site 411154003476 Putative water exit pathway; other site 411154003477 Binuclear center (active site) [active] 411154003478 K-pathway; other site 411154003479 Putative proton exit pathway; other site 411154003480 Rrf2 family protein; Region: rrf2_super; TIGR00738 411154003481 Transcriptional regulator; Region: Rrf2; pfam02082 411154003482 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 411154003483 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 411154003484 Hemerythrin-like domain; Region: Hr-like; cd12108 411154003485 Fe binding site [ion binding]; other site 411154003486 Rrf2 family protein; Region: rrf2_super; TIGR00738 411154003487 Transcriptional regulator; Region: Rrf2; pfam02082 411154003488 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 411154003489 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 411154003490 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 411154003491 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 411154003492 Walker A/P-loop; other site 411154003493 ATP binding site [chemical binding]; other site 411154003494 Q-loop/lid; other site 411154003495 ABC transporter signature motif; other site 411154003496 Walker B; other site 411154003497 D-loop; other site 411154003498 H-loop/switch region; other site 411154003499 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 411154003500 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 411154003501 NosL; Region: NosL; cl01769 411154003502 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 411154003503 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 411154003504 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 411154003505 Fasciclin domain; Region: Fasciclin; pfam02469 411154003506 Cytochrome c; Region: Cytochrom_C; pfam00034 411154003507 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 411154003508 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 411154003509 FeS/SAM binding site; other site 411154003510 HemN C-terminal domain; Region: HemN_C; pfam06969 411154003511 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 411154003512 intersubunit interface [polypeptide binding]; other site 411154003513 active site 411154003514 catalytic residue [active] 411154003515 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 411154003516 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 411154003517 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 411154003518 Ligand Binding Site [chemical binding]; other site 411154003519 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 411154003520 Ligand Binding Site [chemical binding]; other site 411154003521 PAS domain S-box; Region: sensory_box; TIGR00229 411154003522 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 411154003523 putative active site [active] 411154003524 heme pocket [chemical binding]; other site 411154003525 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 411154003526 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154003527 dimer interface [polypeptide binding]; other site 411154003528 phosphorylation site [posttranslational modification] 411154003529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154003530 ATP binding site [chemical binding]; other site 411154003531 Mg2+ binding site [ion binding]; other site 411154003532 G-X-G motif; other site 411154003533 Response regulator receiver domain; Region: Response_reg; pfam00072 411154003534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154003535 active site 411154003536 phosphorylation site [posttranslational modification] 411154003537 intermolecular recognition site; other site 411154003538 dimerization interface [polypeptide binding]; other site 411154003539 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 411154003540 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 411154003541 ligand binding site [chemical binding]; other site 411154003542 flexible hinge region; other site 411154003543 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 411154003544 putative switch regulator; other site 411154003545 non-specific DNA interactions [nucleotide binding]; other site 411154003546 DNA binding site [nucleotide binding] 411154003547 sequence specific DNA binding site [nucleotide binding]; other site 411154003548 putative cAMP binding site [chemical binding]; other site 411154003549 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 411154003550 Ligand Binding Site [chemical binding]; other site 411154003551 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 411154003552 heme-binding site [chemical binding]; other site 411154003553 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 411154003554 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 411154003555 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 411154003556 YceI-like domain; Region: YceI; pfam04264 411154003557 YceI-like domain; Region: YceI; pfam04264 411154003558 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 411154003559 Ligand Binding Site [chemical binding]; other site 411154003560 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 411154003561 Ligand Binding Site [chemical binding]; other site 411154003562 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 411154003563 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 411154003564 Heavy-metal-associated domain; Region: HMA; pfam00403 411154003565 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 411154003566 Soluble P-type ATPase [General function prediction only]; Region: COG4087 411154003567 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 411154003568 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 411154003569 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 411154003570 Low-spin heme binding site [chemical binding]; other site 411154003571 Putative water exit pathway; other site 411154003572 Binuclear center (active site) [active] 411154003573 Putative proton exit pathway; other site 411154003574 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 411154003575 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 411154003576 Cytochrome c; Region: Cytochrom_C; pfam00034 411154003577 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 411154003578 4Fe-4S binding domain; Region: Fer4_5; pfam12801 411154003579 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 411154003580 FixH; Region: FixH; pfam05751 411154003581 Family description; Region: DsbD_2; pfam13386 411154003582 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 411154003583 hydrophobic ligand binding site; other site 411154003584 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 411154003585 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 411154003586 homodimer interface [polypeptide binding]; other site 411154003587 substrate-cofactor binding pocket; other site 411154003588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154003589 catalytic residue [active] 411154003590 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 411154003591 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 411154003592 IHF dimer interface [polypeptide binding]; other site 411154003593 IHF - DNA interface [nucleotide binding]; other site 411154003594 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 411154003595 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 411154003596 putative active site [active] 411154003597 substrate binding site [chemical binding]; other site 411154003598 putative cosubstrate binding site; other site 411154003599 catalytic site [active] 411154003600 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 411154003601 substrate binding site [chemical binding]; other site 411154003602 DEAD-like helicases superfamily; Region: DEXDc; smart00487 411154003603 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 411154003604 ATP binding site [chemical binding]; other site 411154003605 putative Mg++ binding site [ion binding]; other site 411154003606 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 411154003607 nucleotide binding region [chemical binding]; other site 411154003608 ATP-binding site [chemical binding]; other site 411154003609 AAA domain; Region: AAA_28; pfam13521 411154003610 Predicted ATPase [General function prediction only]; Region: COG3911 411154003611 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 411154003612 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 411154003613 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 411154003614 hinge; other site 411154003615 active site 411154003616 putative hydrolase; Provisional; Region: PRK02113 411154003617 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 411154003618 Predicted esterase [General function prediction only]; Region: COG0400 411154003619 putative hydrolase; Provisional; Region: PRK11460 411154003620 Predicted membrane protein [Function unknown]; Region: COG4818 411154003621 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 411154003622 active site 411154003623 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 411154003624 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 411154003625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154003626 dimer interface [polypeptide binding]; other site 411154003627 phosphorylation site [posttranslational modification] 411154003628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154003629 ATP binding site [chemical binding]; other site 411154003630 Mg2+ binding site [ion binding]; other site 411154003631 G-X-G motif; other site 411154003632 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 411154003633 GAF domain; Region: GAF; pfam01590 411154003634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 411154003635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154003636 dimer interface [polypeptide binding]; other site 411154003637 phosphorylation site [posttranslational modification] 411154003638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154003639 ATP binding site [chemical binding]; other site 411154003640 Mg2+ binding site [ion binding]; other site 411154003641 G-X-G motif; other site 411154003642 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 411154003643 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 411154003644 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 411154003645 Walker A/P-loop; other site 411154003646 ATP binding site [chemical binding]; other site 411154003647 Q-loop/lid; other site 411154003648 ABC transporter signature motif; other site 411154003649 Walker B; other site 411154003650 D-loop; other site 411154003651 H-loop/switch region; other site 411154003652 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 411154003653 putative ligand binding site [chemical binding]; other site 411154003654 methionine sulfoxide reductase A; Provisional; Region: PRK14054 411154003655 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 411154003656 homodecamer interface [polypeptide binding]; other site 411154003657 GTP cyclohydrolase I; Provisional; Region: PLN03044 411154003658 active site 411154003659 putative catalytic site residues [active] 411154003660 zinc binding site [ion binding]; other site 411154003661 GTP-CH-I/GFRP interaction surface; other site 411154003662 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154003663 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 411154003664 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154003665 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 411154003666 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 411154003667 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 411154003668 putative ligand binding site [chemical binding]; other site 411154003669 NAD binding site [chemical binding]; other site 411154003670 dimerization interface [polypeptide binding]; other site 411154003671 catalytic site [active] 411154003672 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 411154003673 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 411154003674 catalytic residue [active] 411154003675 4Fe-4S binding domain; Region: Fer4; cl02805 411154003676 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 411154003677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154003678 Methyltransferase domain; Region: Methyltransf_31; pfam13847 411154003679 S-adenosylmethionine binding site [chemical binding]; other site 411154003680 DNA polymerase III DnaE; Validated; Region: dnaE; PRK05898 411154003681 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 411154003682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 411154003683 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154003684 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 411154003685 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154003686 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154003687 GTP-binding protein YchF; Reviewed; Region: PRK09601 411154003688 YchF GTPase; Region: YchF; cd01900 411154003689 G1 box; other site 411154003690 GTP/Mg2+ binding site [chemical binding]; other site 411154003691 Switch I region; other site 411154003692 G2 box; other site 411154003693 Switch II region; other site 411154003694 G3 box; other site 411154003695 G4 box; other site 411154003696 G5 box; other site 411154003697 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 411154003698 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 411154003699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154003700 ATP binding site [chemical binding]; other site 411154003701 Mg2+ binding site [ion binding]; other site 411154003702 G-X-G motif; other site 411154003703 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 411154003704 ATP binding site [chemical binding]; other site 411154003705 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 411154003706 active site 411154003707 putative metal-binding site [ion binding]; other site 411154003708 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 411154003709 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 411154003710 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 411154003711 CAP-like domain; other site 411154003712 active site 411154003713 primary dimer interface [polypeptide binding]; other site 411154003714 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 411154003715 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 411154003716 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 411154003717 non-specific DNA binding site [nucleotide binding]; other site 411154003718 salt bridge; other site 411154003719 sequence-specific DNA binding site [nucleotide binding]; other site 411154003720 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 411154003721 putative active site [active] 411154003722 Zn binding site [ion binding]; other site 411154003723 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 411154003724 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 411154003725 putative DNA binding site [nucleotide binding]; other site 411154003726 putative Zn2+ binding site [ion binding]; other site 411154003727 AsnC family; Region: AsnC_trans_reg; pfam01037 411154003728 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 411154003729 DinB superfamily; Region: DinB_2; pfam12867 411154003730 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 411154003731 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 411154003732 intracellular protease, PfpI family; Region: PfpI; TIGR01382 411154003733 proposed catalytic triad [active] 411154003734 conserved cys residue [active] 411154003735 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 411154003736 active site 411154003737 dimer interface [polypeptide binding]; other site 411154003738 metal binding site [ion binding]; metal-binding site 411154003739 Proline dehydrogenase; Region: Pro_dh; cl03282 411154003740 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 411154003741 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 411154003742 putative acyl-acceptor binding pocket; other site 411154003743 hypothetical protein; Provisional; Region: PRK12378 411154003744 pterin-4-alpha-carbinolamine dehydratase; Validated; Region: phhB; PRK00823 411154003745 aromatic arch; other site 411154003746 DCoH dimer interaction site [polypeptide binding]; other site 411154003747 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 411154003748 DCoH tetramer interaction site [polypeptide binding]; other site 411154003749 substrate binding site [chemical binding]; other site 411154003750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 411154003751 NAD(P) binding site [chemical binding]; other site 411154003752 active site 411154003753 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 411154003754 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 411154003755 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 411154003756 putative carbohydrate kinase; Provisional; Region: PRK10565 411154003757 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 411154003758 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 411154003759 putative substrate binding site [chemical binding]; other site 411154003760 putative ATP binding site [chemical binding]; other site 411154003761 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 411154003762 active sites [active] 411154003763 tetramer interface [polypeptide binding]; other site 411154003764 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 411154003765 Clp amino terminal domain; Region: Clp_N; pfam02861 411154003766 Clp amino terminal domain; Region: Clp_N; pfam02861 411154003767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154003768 Walker A motif; other site 411154003769 ATP binding site [chemical binding]; other site 411154003770 Walker B motif; other site 411154003771 arginine finger; other site 411154003772 UvrB/uvrC motif; Region: UVR; pfam02151 411154003773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154003774 Walker A motif; other site 411154003775 ATP binding site [chemical binding]; other site 411154003776 Walker B motif; other site 411154003777 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 411154003778 DNA gyrase subunit A; Validated; Region: PRK05560 411154003779 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 411154003780 CAP-like domain; other site 411154003781 active site 411154003782 primary dimer interface [polypeptide binding]; other site 411154003783 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 411154003784 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 411154003785 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 411154003786 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 411154003787 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 411154003788 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 411154003789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154003790 binding surface 411154003791 TPR repeat; Region: TPR_11; pfam13414 411154003792 TPR motif; other site 411154003793 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 411154003794 NlpC/P60 family; Region: NLPC_P60; pfam00877 411154003795 acetyl-CoA C-acetyltransferase; Region: PLN02644 411154003796 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 411154003797 dimer interface [polypeptide binding]; other site 411154003798 active site 411154003799 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 411154003800 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 411154003801 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 411154003802 Zn2+ binding site [ion binding]; other site 411154003803 Mg2+ binding site [ion binding]; other site 411154003804 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 411154003805 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 411154003806 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 411154003807 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 411154003808 NAD(P) binding site [chemical binding]; other site 411154003809 catalytic residues [active] 411154003810 Protein of unknown function DUF72; Region: DUF72; pfam01904 411154003811 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 411154003812 nudix motif; other site 411154003813 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 411154003814 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 411154003815 Mechanosensitive ion channel; Region: MS_channel; pfam00924 411154003816 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 411154003817 putative catalytic site [active] 411154003818 putative metal binding site [ion binding]; other site 411154003819 putative phosphate binding site [ion binding]; other site 411154003820 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 411154003821 Mechanosensitive ion channel; Region: MS_channel; pfam00924 411154003822 integral membrane protein; Region: integ_memb_HG; TIGR03954 411154003823 UDP-glucose 4-epimerase; Region: PLN02240 411154003824 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 411154003825 NAD binding site [chemical binding]; other site 411154003826 homodimer interface [polypeptide binding]; other site 411154003827 active site 411154003828 substrate binding site [chemical binding]; other site 411154003829 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 411154003830 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 411154003831 short chain dehydrogenase; Provisional; Region: PRK07326 411154003832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 411154003833 NAD(P) binding site [chemical binding]; other site 411154003834 active site 411154003835 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 411154003836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 411154003837 NAD(P) binding site [chemical binding]; other site 411154003838 active site 411154003839 Prostaglandin dehydrogenases; Region: PGDH; cd05288 411154003840 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 411154003841 NAD(P) binding site [chemical binding]; other site 411154003842 substrate binding site [chemical binding]; other site 411154003843 dimer interface [polypeptide binding]; other site 411154003844 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 411154003845 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 411154003846 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 411154003847 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 411154003848 serine O-acetyltransferase; Region: cysE; TIGR01172 411154003849 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 411154003850 trimer interface [polypeptide binding]; other site 411154003851 active site 411154003852 substrate binding site [chemical binding]; other site 411154003853 CoA binding site [chemical binding]; other site 411154003854 cysteine synthase B; Region: cysM; TIGR01138 411154003855 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 411154003856 dimer interface [polypeptide binding]; other site 411154003857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154003858 catalytic residue [active] 411154003859 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 411154003860 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 411154003861 ligand binding site [chemical binding]; other site 411154003862 flexible hinge region; other site 411154003863 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 411154003864 putative switch regulator; other site 411154003865 non-specific DNA interactions [nucleotide binding]; other site 411154003866 DNA binding site [nucleotide binding] 411154003867 sequence specific DNA binding site [nucleotide binding]; other site 411154003868 putative cAMP binding site [chemical binding]; other site 411154003869 DEAD-like helicases superfamily; Region: DEXDc; smart00487 411154003870 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 411154003871 ATP binding site [chemical binding]; other site 411154003872 putative Mg++ binding site [ion binding]; other site 411154003873 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 411154003874 nucleotide binding region [chemical binding]; other site 411154003875 ATP-binding site [chemical binding]; other site 411154003876 Transglycosylase; Region: Transgly; pfam00912 411154003877 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 411154003878 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 411154003879 SdiA-regulated; Region: SdiA-regulated; cd09971 411154003880 putative active site [active] 411154003881 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 411154003882 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 411154003883 active site 411154003884 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 411154003885 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 411154003886 ATP-grasp domain; Region: ATP-grasp_4; cl17255 411154003887 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 411154003888 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 411154003889 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 411154003890 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 411154003891 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 411154003892 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 411154003893 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 411154003894 3D domain; Region: 3D; cl01439 411154003895 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 411154003896 substrate binding pocket [chemical binding]; other site 411154003897 Ion channel; Region: Ion_trans_2; pfam07885 411154003898 Eukaryotic homologues of bacterial periplasmic substrate binding proteins; Region: PBPe; smart00079 411154003899 aspartate kinase III; Validated; Region: PRK09084 411154003900 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 411154003901 nucleotide binding site [chemical binding]; other site 411154003902 substrate binding site [chemical binding]; other site 411154003903 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 411154003904 dimer interface [polypeptide binding]; other site 411154003905 allosteric regulatory binding pocket; other site 411154003906 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 411154003907 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 411154003908 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 411154003909 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 411154003910 transmembrane helices; other site 411154003911 TrkA-C domain; Region: TrkA_C; pfam02080 411154003912 TrkA-C domain; Region: TrkA_C; pfam02080 411154003913 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 411154003914 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 411154003915 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 411154003916 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 411154003917 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 411154003918 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 411154003919 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 411154003920 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 411154003921 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 411154003922 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 411154003923 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 411154003924 ligand binding site [chemical binding]; other site 411154003925 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 411154003926 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 411154003927 Family of unknown function (DUF490); Region: DUF490; pfam04357 411154003928 Surface antigen; Region: Bac_surface_Ag; pfam01103 411154003929 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 411154003930 active site 411154003931 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 411154003932 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 411154003933 active site 411154003934 SnoaL-like domain; Region: SnoaL_2; pfam12680 411154003935 DinB superfamily; Region: DinB_2; pfam12867 411154003936 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 411154003937 Ligand Binding Site [chemical binding]; other site 411154003938 Dodecin; Region: Dodecin; pfam07311 411154003939 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 411154003940 Domain of unknown function (DUF336); Region: DUF336; pfam03928 411154003941 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 411154003942 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 411154003943 putative NAD(P) binding site [chemical binding]; other site 411154003944 dimer interface [polypeptide binding]; other site 411154003945 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 411154003946 DNA-binding site [nucleotide binding]; DNA binding site 411154003947 RNA-binding motif; other site 411154003948 Fatty acid desaturase; Region: FA_desaturase; pfam00487 411154003949 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 411154003950 putative di-iron ligands [ion binding]; other site 411154003951 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 411154003952 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 411154003953 DNA-binding site [nucleotide binding]; DNA binding site 411154003954 RNA-binding motif; other site 411154003955 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 411154003956 DNA-binding site [nucleotide binding]; DNA binding site 411154003957 RNA-binding motif; other site 411154003958 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 411154003959 DNA-binding site [nucleotide binding]; DNA binding site 411154003960 RNA-binding motif; other site 411154003961 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 411154003962 Cation efflux family; Region: Cation_efflux; pfam01545 411154003963 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 411154003964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 411154003965 Coenzyme A binding pocket [chemical binding]; other site 411154003966 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 411154003967 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 411154003968 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 411154003969 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 411154003970 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 411154003971 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 411154003972 Transposase, Mutator family; Region: Transposase_mut; pfam00872 411154003973 MULE transposase domain; Region: MULE; pfam10551 411154003974 putative transposase OrfB; Reviewed; Region: PHA02517 411154003975 HTH-like domain; Region: HTH_21; pfam13276 411154003976 Integrase core domain; Region: rve; pfam00665 411154003977 Integrase core domain; Region: rve_3; pfam13683 411154003978 Homeodomain-like domain; Region: HTH_23; cl17451 411154003979 WYL domain; Region: WYL; pfam13280 411154003980 hypothetical protein; Provisional; Region: PRK06153 411154003981 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 411154003982 ATP binding site [chemical binding]; other site 411154003983 substrate interface [chemical binding]; other site 411154003984 Domain of unknown function (DUF4251); Region: DUF4251; pfam14059 411154003985 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 411154003986 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 411154003987 nucleoside/Zn binding site; other site 411154003988 dimer interface [polypeptide binding]; other site 411154003989 catalytic motif [active] 411154003990 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 411154003991 30S subunit binding site; other site 411154003992 aconitate hydratase; Validated; Region: PRK07229 411154003993 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 411154003994 substrate binding site [chemical binding]; other site 411154003995 ligand binding site [chemical binding]; other site 411154003996 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 411154003997 substrate binding site [chemical binding]; other site 411154003998 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 411154003999 Phosphopantetheine attachment site; Region: PP-binding; cl09936 411154004000 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 411154004001 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 411154004002 dimer interface [polypeptide binding]; other site 411154004003 active site 411154004004 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 411154004005 active site 2 [active] 411154004006 dimer interface [polypeptide binding]; other site 411154004007 active site 1 [active] 411154004008 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 411154004009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 411154004010 NAD(P) binding site [chemical binding]; other site 411154004011 active site 411154004012 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 411154004013 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 411154004014 malonyl-CoA binding site [chemical binding]; other site 411154004015 dimer interface [polypeptide binding]; other site 411154004016 active site 411154004017 product binding site; other site 411154004018 Methyltransferase domain; Region: Methyltransf_31; pfam13847 411154004019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154004020 S-adenosylmethionine binding site [chemical binding]; other site 411154004021 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 411154004022 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 411154004023 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 411154004024 ligand binding site [chemical binding]; other site 411154004025 murein transglycosylase A; Provisional; Region: mltA; PRK11162 411154004026 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 411154004027 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 411154004028 tetramer interface [polypeptide binding]; other site 411154004029 TPP-binding site [chemical binding]; other site 411154004030 heterodimer interface [polypeptide binding]; other site 411154004031 phosphorylation loop region [posttranslational modification] 411154004032 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 411154004033 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 411154004034 alpha subunit interface [polypeptide binding]; other site 411154004035 TPP binding site [chemical binding]; other site 411154004036 heterodimer interface [polypeptide binding]; other site 411154004037 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 411154004038 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 411154004039 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 411154004040 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 411154004041 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 411154004042 putative rRNA binding site [nucleotide binding]; other site 411154004043 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 411154004044 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 411154004045 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 411154004046 polyphosphate kinase; Provisional; Region: PRK05443 411154004047 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 411154004048 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 411154004049 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 411154004050 domain interface [polypeptide binding]; other site 411154004051 active site 411154004052 catalytic site [active] 411154004053 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 411154004054 domain interface [polypeptide binding]; other site 411154004055 active site 411154004056 catalytic site [active] 411154004057 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 411154004058 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 411154004059 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 411154004060 ligand binding site [chemical binding]; other site 411154004061 active site 411154004062 UGI interface [polypeptide binding]; other site 411154004063 catalytic site [active] 411154004064 MutS domain III; Region: MutS_III; pfam05192 411154004065 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154004066 Walker A/P-loop; other site 411154004067 ATP binding site [chemical binding]; other site 411154004068 Q-loop/lid; other site 411154004069 ABC transporter signature motif; other site 411154004070 Walker B; other site 411154004071 D-loop; other site 411154004072 H-loop/switch region; other site 411154004073 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 411154004074 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 411154004075 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 411154004076 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 411154004077 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 411154004078 Tetramer interface [polypeptide binding]; other site 411154004079 active site 411154004080 FMN-binding site [chemical binding]; other site 411154004081 Response regulator receiver domain; Region: Response_reg; pfam00072 411154004082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154004083 active site 411154004084 phosphorylation site [posttranslational modification] 411154004085 intermolecular recognition site; other site 411154004086 dimerization interface [polypeptide binding]; other site 411154004087 PAS fold; Region: PAS_4; pfam08448 411154004088 PAS fold; Region: PAS_4; pfam08448 411154004089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 411154004090 PAS domain; Region: PAS_9; pfam13426 411154004091 putative active site [active] 411154004092 heme pocket [chemical binding]; other site 411154004093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 411154004094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154004095 dimer interface [polypeptide binding]; other site 411154004096 phosphorylation site [posttranslational modification] 411154004097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154004098 ATP binding site [chemical binding]; other site 411154004099 Mg2+ binding site [ion binding]; other site 411154004100 G-X-G motif; other site 411154004101 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 411154004102 FAD binding domain; Region: FAD_binding_4; pfam01565 411154004103 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 411154004104 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 411154004105 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 411154004106 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 411154004107 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 411154004108 Beta-lactamase; Region: Beta-lactamase; cl17358 411154004109 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 411154004110 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 411154004111 Cysteine-rich domain; Region: CCG; pfam02754 411154004112 Cysteine-rich domain; Region: CCG; pfam02754 411154004113 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 411154004114 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 411154004115 mce related protein; Region: MCE; pfam02470 411154004116 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 411154004117 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 411154004118 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 411154004119 active site 411154004120 metal binding site [ion binding]; metal-binding site 411154004121 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 411154004122 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 411154004123 homotrimer interaction site [polypeptide binding]; other site 411154004124 putative active site [active] 411154004125 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 411154004126 active site 411154004127 dimer interfaces [polypeptide binding]; other site 411154004128 catalytic residues [active] 411154004129 6-phosphofructokinase; Provisional; Region: PRK03202 411154004130 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 411154004131 active site 411154004132 ADP/pyrophosphate binding site [chemical binding]; other site 411154004133 dimerization interface [polypeptide binding]; other site 411154004134 allosteric effector site; other site 411154004135 fructose-1,6-bisphosphate binding site; other site 411154004136 Family of unknown function (DUF490); Region: DUF490; pfam04357 411154004137 UGMP family protein; Validated; Region: PRK09604 411154004138 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 411154004139 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 411154004140 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 411154004141 RNA methyltransferase, RsmE family; Region: TIGR00046 411154004142 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 411154004143 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 411154004144 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 411154004145 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 411154004146 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 411154004147 acyl-activating enzyme (AAE) consensus motif; other site 411154004148 active site 411154004149 AMP binding site [chemical binding]; other site 411154004150 CoA binding site [chemical binding]; other site 411154004151 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 411154004152 active site 411154004153 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 411154004154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154004155 Predicted exporter [General function prediction only]; Region: COG4258 411154004156 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 411154004157 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 411154004158 Ligand binding site; other site 411154004159 Putative Catalytic site; other site 411154004160 DXD motif; other site 411154004161 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 411154004162 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 411154004163 active site 2 [active] 411154004164 active site 1 [active] 411154004165 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 411154004166 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 411154004167 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 411154004168 NodB motif; other site 411154004169 active site 411154004170 catalytic site [active] 411154004171 metal binding site [ion binding]; metal-binding site 411154004172 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 411154004173 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 411154004174 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 411154004175 dimer interface [polypeptide binding]; other site 411154004176 active site 411154004177 Phosphopantetheine attachment site; Region: PP-binding; cl09936 411154004178 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 411154004179 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 411154004180 active site 411154004181 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 411154004182 active site 411154004183 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 411154004184 active site 1 [active] 411154004185 active site 2 [active] 411154004186 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 411154004187 putative acyl-acceptor binding pocket; other site 411154004188 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 411154004189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 411154004190 NAD(P) binding site [chemical binding]; other site 411154004191 active site 411154004192 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 411154004193 active sites [active] 411154004194 tetramer interface [polypeptide binding]; other site 411154004195 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 411154004196 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 411154004197 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 411154004198 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 411154004199 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 411154004200 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 411154004201 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 411154004202 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 411154004203 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 411154004204 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 411154004205 E3 interaction surface; other site 411154004206 lipoyl attachment site [posttranslational modification]; other site 411154004207 e3 binding domain; Region: E3_binding; pfam02817 411154004208 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 411154004209 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 411154004210 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 411154004211 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 411154004212 dimer interface [polypeptide binding]; other site 411154004213 TPP-binding site [chemical binding]; other site 411154004214 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 411154004215 Dodecin; Region: Dodecin; pfam07311 411154004216 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 411154004217 CheB methylesterase; Region: CheB_methylest; pfam01339 411154004218 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 411154004219 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 411154004220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154004221 S-adenosylmethionine binding site [chemical binding]; other site 411154004222 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 411154004223 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 411154004224 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 411154004225 putative active site [active] 411154004226 heme pocket [chemical binding]; other site 411154004227 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 411154004228 putative active site [active] 411154004229 heme pocket [chemical binding]; other site 411154004230 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 411154004231 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154004232 dimer interface [polypeptide binding]; other site 411154004233 phosphorylation site [posttranslational modification] 411154004234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154004235 ATP binding site [chemical binding]; other site 411154004236 Mg2+ binding site [ion binding]; other site 411154004237 G-X-G motif; other site 411154004238 Response regulator receiver domain; Region: Response_reg; pfam00072 411154004239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154004240 active site 411154004241 phosphorylation site [posttranslational modification] 411154004242 intermolecular recognition site; other site 411154004243 dimerization interface [polypeptide binding]; other site 411154004244 Response regulator receiver domain; Region: Response_reg; pfam00072 411154004245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154004246 active site 411154004247 phosphorylation site [posttranslational modification] 411154004248 intermolecular recognition site; other site 411154004249 dimerization interface [polypeptide binding]; other site 411154004250 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 411154004251 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 411154004252 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 411154004253 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 411154004254 active site 411154004255 catalytic tetrad [active] 411154004256 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 411154004257 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 411154004258 ligand binding site [chemical binding]; other site 411154004259 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 411154004260 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 411154004261 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 411154004262 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 411154004263 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 411154004264 Two component regulator propeller; Region: Reg_prop; pfam07494 411154004265 Two component regulator propeller; Region: Reg_prop; pfam07494 411154004266 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 411154004267 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 411154004268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154004269 dimer interface [polypeptide binding]; other site 411154004270 phosphorylation site [posttranslational modification] 411154004271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154004272 ATP binding site [chemical binding]; other site 411154004273 Mg2+ binding site [ion binding]; other site 411154004274 G-X-G motif; other site 411154004275 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 411154004276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154004277 active site 411154004278 phosphorylation site [posttranslational modification] 411154004279 intermolecular recognition site; other site 411154004280 dimerization interface [polypeptide binding]; other site 411154004281 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 411154004282 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 411154004283 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 411154004284 Sulfatase; Region: Sulfatase; cl17466 411154004285 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 411154004286 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 411154004287 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 411154004288 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 411154004289 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 411154004290 Domain of unknown function (DUF718); Region: DUF718; pfam05336 411154004291 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 411154004292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154004293 putative substrate translocation pore; other site 411154004294 short chain dehydrogenase; Provisional; Region: PRK08628 411154004295 classical (c) SDRs; Region: SDR_c; cd05233 411154004296 NAD(P) binding site [chemical binding]; other site 411154004297 active site 411154004298 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 411154004299 Amidohydrolase; Region: Amidohydro_2; pfam04909 411154004300 active site 411154004301 altronate oxidoreductase; Provisional; Region: PRK03643 411154004302 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 411154004303 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 411154004304 galactarate dehydratase; Region: galactar-dH20; TIGR03248 411154004305 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 411154004306 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 411154004307 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 411154004308 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 411154004309 active site 411154004310 intersubunit interface [polypeptide binding]; other site 411154004311 catalytic residue [active] 411154004312 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 411154004313 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 411154004314 substrate binding site [chemical binding]; other site 411154004315 ATP binding site [chemical binding]; other site 411154004316 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 411154004317 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 411154004318 putative NAD(P) binding site [chemical binding]; other site 411154004319 catalytic Zn binding site [ion binding]; other site 411154004320 structural Zn binding site [ion binding]; other site 411154004321 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 411154004322 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 411154004323 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 411154004324 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154004325 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154004326 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 411154004327 starch binding outer membrane protein SusD; Region: SusD; cd08977 411154004328 FOG: PKD repeat [General function prediction only]; Region: COG3291 411154004329 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 411154004330 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 411154004331 Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178 411154004332 calcium binding site [ion binding]; other site 411154004333 active site 411154004334 catalytic residues [active] 411154004335 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 411154004336 active site 411154004337 catalytic residues [active] 411154004338 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 411154004339 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 411154004340 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 411154004341 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 411154004342 NAD binding site [chemical binding]; other site 411154004343 catalytic Zn binding site [ion binding]; other site 411154004344 substrate binding site [chemical binding]; other site 411154004345 structural Zn binding site [ion binding]; other site 411154004346 Putative esterase; Region: Esterase; pfam00756 411154004347 S-formylglutathione hydrolase; Region: PLN02442 411154004348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 411154004349 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 411154004350 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 411154004351 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 411154004352 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 411154004353 active site 411154004354 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 411154004355 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 411154004356 active site 411154004357 NTP binding site [chemical binding]; other site 411154004358 metal binding triad [ion binding]; metal-binding site 411154004359 antibiotic binding site [chemical binding]; other site 411154004360 Protein of unknown function DUF86; Region: DUF86; pfam01934 411154004361 Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178 411154004362 calcium binding site [ion binding]; other site 411154004363 active site 411154004364 catalytic residues [active] 411154004365 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 411154004366 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 411154004367 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 411154004368 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 411154004369 putative metal binding site [ion binding]; other site 411154004370 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 411154004371 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 411154004372 aromatic chitin/cellulose binding site residues [chemical binding]; other site 411154004373 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 411154004374 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 411154004375 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 411154004376 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 411154004377 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 411154004378 Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178 411154004379 calcium binding site [ion binding]; other site 411154004380 active site 411154004381 catalytic residues [active] 411154004382 Beta-lactamase; Region: Beta-lactamase; pfam00144 411154004383 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 411154004384 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 411154004385 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 411154004386 starch binding outer membrane protein SusD; Region: SusD; cl17845 411154004387 SusD family; Region: SusD; pfam07980 411154004388 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 411154004389 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154004390 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 411154004391 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 411154004392 FecR protein; Region: FecR; pfam04773 411154004393 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 411154004394 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 411154004395 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 411154004396 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 411154004397 DNA binding residues [nucleotide binding] 411154004398 Trehalase; Region: Trehalase; cl17346 411154004399 hypothetical protein; Provisional; Region: PRK06148 411154004400 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 411154004401 active site 411154004402 ATP binding site [chemical binding]; other site 411154004403 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 411154004404 inhibitor-cofactor binding pocket; inhibition site 411154004405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154004406 catalytic residue [active] 411154004407 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 411154004408 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 411154004409 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 411154004410 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 411154004411 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 411154004412 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 411154004413 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 411154004414 active site 411154004415 Domain of unknown function (DUF1704); Region: DUF1704; pfam08014 411154004416 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 411154004417 glutathione synthetase; Provisional; Region: PRK12458 411154004418 ATP-grasp domain; Region: ATP-grasp_4; cl17255 411154004419 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily; Region: M14_ASTE_ASPA_like; cd06230 411154004420 active site 411154004421 Zn binding site [ion binding]; other site 411154004422 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 411154004423 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 411154004424 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 411154004425 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 411154004426 oligomer interface [polypeptide binding]; other site 411154004427 metal binding site [ion binding]; metal-binding site 411154004428 metal binding site [ion binding]; metal-binding site 411154004429 Cl binding site [ion binding]; other site 411154004430 aspartate ring; other site 411154004431 basic sphincter; other site 411154004432 putative hydrophobic gate; other site 411154004433 periplasmic entrance; other site 411154004434 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 411154004435 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 411154004436 ATP binding site [chemical binding]; other site 411154004437 putative Mg++ binding site [ion binding]; other site 411154004438 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 411154004439 nucleotide binding region [chemical binding]; other site 411154004440 ATP-binding site [chemical binding]; other site 411154004441 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 411154004442 HRDC domain; Region: HRDC; pfam00570 411154004443 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 411154004444 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 411154004445 active site 411154004446 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 411154004447 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 411154004448 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 411154004449 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 411154004450 Cation efflux family; Region: Cation_efflux; pfam01545 411154004451 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 411154004452 putative metal binding site [ion binding]; other site 411154004453 Uncharacterized conserved protein [Function unknown]; Region: COG1432 411154004454 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 411154004455 Pirin-related protein [General function prediction only]; Region: COG1741 411154004456 Pirin; Region: Pirin; pfam02678 411154004457 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 411154004458 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 411154004459 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 411154004460 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 411154004461 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 411154004462 metal binding site [ion binding]; metal-binding site 411154004463 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 411154004464 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 411154004465 substrate binding site [chemical binding]; other site 411154004466 glutamase interaction surface [polypeptide binding]; other site 411154004467 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 411154004468 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 411154004469 catalytic residues [active] 411154004470 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 411154004471 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 411154004472 putative active site [active] 411154004473 oxyanion strand; other site 411154004474 catalytic triad [active] 411154004475 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 411154004476 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 411154004477 active site 411154004478 motif I; other site 411154004479 motif II; other site 411154004480 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 411154004481 putative active site pocket [active] 411154004482 4-fold oligomerization interface [polypeptide binding]; other site 411154004483 metal binding residues [ion binding]; metal-binding site 411154004484 3-fold/trimer interface [polypeptide binding]; other site 411154004485 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 411154004486 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 411154004487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154004488 homodimer interface [polypeptide binding]; other site 411154004489 catalytic residue [active] 411154004490 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 411154004491 histidinol dehydrogenase; Region: hisD; TIGR00069 411154004492 NAD binding site [chemical binding]; other site 411154004493 dimerization interface [polypeptide binding]; other site 411154004494 product binding site; other site 411154004495 substrate binding site [chemical binding]; other site 411154004496 zinc binding site [ion binding]; other site 411154004497 catalytic residues [active] 411154004498 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 411154004499 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 411154004500 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 411154004501 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 411154004502 SPFH domain / Band 7 family; Region: Band_7; pfam01145 411154004503 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 411154004504 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 411154004505 NAD(P) binding site [chemical binding]; other site 411154004506 homotetramer interface [polypeptide binding]; other site 411154004507 homodimer interface [polypeptide binding]; other site 411154004508 active site 411154004509 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 411154004510 CoA binding domain; Region: CoA_binding; smart00881 411154004511 CoA-ligase; Region: Ligase_CoA; pfam00549 411154004512 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 411154004513 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 411154004514 Penicillinase repressor; Region: Pencillinase_R; pfam03965 411154004515 SnoaL-like domain; Region: SnoaL_2; pfam12680 411154004516 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 411154004517 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 411154004518 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 411154004519 trimer interface [polypeptide binding]; other site 411154004520 active site 411154004521 UDP-GlcNAc binding site [chemical binding]; other site 411154004522 lipid binding site [chemical binding]; lipid-binding site 411154004523 elongation factor P; Validated; Region: PRK00529 411154004524 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 411154004525 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 411154004526 RNA binding site [nucleotide binding]; other site 411154004527 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 411154004528 RNA binding site [nucleotide binding]; other site 411154004529 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 411154004530 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 411154004531 active site 411154004532 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 411154004533 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 411154004534 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 411154004535 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 411154004536 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 411154004537 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 411154004538 trimer interface [polypeptide binding]; other site 411154004539 active site 411154004540 UDP-GlcNAc binding site [chemical binding]; other site 411154004541 lipid binding site [chemical binding]; lipid-binding site 411154004542 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 411154004543 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 411154004544 Zn2+ binding site [ion binding]; other site 411154004545 Mg2+ binding site [ion binding]; other site 411154004546 Response regulator receiver domain; Region: Response_reg; pfam00072 411154004547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154004548 active site 411154004549 phosphorylation site [posttranslational modification] 411154004550 intermolecular recognition site; other site 411154004551 dimerization interface [polypeptide binding]; other site 411154004552 PglZ domain; Region: PglZ; pfam08665 411154004553 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 411154004554 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 411154004555 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 411154004556 hexamer interface [polypeptide binding]; other site 411154004557 ligand binding site [chemical binding]; other site 411154004558 putative active site [active] 411154004559 NAD(P) binding site [chemical binding]; other site 411154004560 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 411154004561 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 411154004562 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 411154004563 catalytic triad [active] 411154004564 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 411154004565 endonuclease III; Region: ENDO3c; smart00478 411154004566 minor groove reading motif; other site 411154004567 helix-hairpin-helix signature motif; other site 411154004568 substrate binding pocket [chemical binding]; other site 411154004569 active site 411154004570 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 411154004571 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 411154004572 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 411154004573 DNA binding residues [nucleotide binding] 411154004574 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 411154004575 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 411154004576 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 411154004577 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 411154004578 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 411154004579 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 411154004580 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 411154004581 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 411154004582 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 411154004583 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 411154004584 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 411154004585 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 411154004586 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 411154004587 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 411154004588 catalytic residue [active] 411154004589 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 411154004590 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 411154004591 dimer interface [polypeptide binding]; other site 411154004592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154004593 catalytic residue [active] 411154004594 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 411154004595 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 411154004596 hypothetical protein; Provisional; Region: PRK14623 411154004597 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 411154004598 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 411154004599 putative catalytic residues [active] 411154004600 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 411154004601 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 411154004602 tetramer interface [polypeptide binding]; other site 411154004603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154004604 catalytic residue [active] 411154004605 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 411154004606 active site 411154004607 peptide chain release factor 2; Validated; Region: prfB; PRK00578 411154004608 PCRF domain; Region: PCRF; pfam03462 411154004609 RF-1 domain; Region: RF-1; pfam00472 411154004610 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 411154004611 ArsC family; Region: ArsC; pfam03960 411154004612 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154004613 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154004614 fumarate hydratase; Reviewed; Region: fumC; PRK00485 411154004615 Class II fumarases; Region: Fumarase_classII; cd01362 411154004616 active site 411154004617 tetramer interface [polypeptide binding]; other site 411154004618 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 411154004619 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 411154004620 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 411154004621 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 411154004622 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 411154004623 active site 411154004624 motif I; other site 411154004625 motif II; other site 411154004626 prenyltransferase; Reviewed; Region: ubiA; PRK12872 411154004627 UbiA prenyltransferase family; Region: UbiA; pfam01040 411154004628 Maf-like protein; Region: Maf; pfam02545 411154004629 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 411154004630 active site 411154004631 dimer interface [polypeptide binding]; other site 411154004632 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 411154004633 Mechanosensitive ion channel; Region: MS_channel; pfam00924 411154004634 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 411154004635 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 411154004636 Tho complex subunit 7; Region: THOC7; pfam05615 411154004637 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 411154004638 Na binding site [ion binding]; other site 411154004639 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 411154004640 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 411154004641 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 411154004642 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 411154004643 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 411154004644 putative hydrophobic ligand binding site [chemical binding]; other site 411154004645 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 411154004646 classical (c) SDRs; Region: SDR_c; cd05233 411154004647 NAD(P) binding site [chemical binding]; other site 411154004648 active site 411154004649 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 411154004650 DNA photolyase; Region: DNA_photolyase; pfam00875 411154004651 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 411154004652 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 411154004653 Ligand binding site; other site 411154004654 oligomer interface; other site 411154004655 AAA domain; Region: AAA_30; pfam13604 411154004656 Family description; Region: UvrD_C_2; pfam13538 411154004657 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 411154004658 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 411154004659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154004660 S-adenosylmethionine binding site [chemical binding]; other site 411154004661 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 411154004662 active site 411154004663 catalytic residues [active] 411154004664 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14970 411154004665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154004666 Walker A motif; other site 411154004667 ATP binding site [chemical binding]; other site 411154004668 Walker B motif; other site 411154004669 arginine finger; other site 411154004670 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 411154004671 active site 411154004672 dinuclear metal binding site [ion binding]; other site 411154004673 dimerization interface [polypeptide binding]; other site 411154004674 exopolyphosphatase; Region: exo_poly_only; TIGR03706 411154004675 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 411154004676 polyphosphate kinase; Provisional; Region: PRK05443 411154004677 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 411154004678 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 411154004679 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 411154004680 domain interface [polypeptide binding]; other site 411154004681 active site 411154004682 catalytic site [active] 411154004683 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 411154004684 domain interface [polypeptide binding]; other site 411154004685 active site 411154004686 catalytic site [active] 411154004687 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 411154004688 catalytic core [active] 411154004689 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 411154004690 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 411154004691 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 411154004692 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 411154004693 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 411154004694 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 411154004695 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 411154004696 HYR domain; Region: HYR; pfam02494 411154004697 HYR domain; Region: HYR; pfam02494 411154004698 HYR domain; Region: HYR; pfam02494 411154004699 HYR domain; Region: HYR; pfam02494 411154004700 HYR domain; Region: HYR; pfam02494 411154004701 HYR domain; Region: HYR; pfam02494 411154004702 HYR domain; Region: HYR; pfam02494 411154004703 HYR domain; Region: HYR; pfam02494 411154004704 HYR domain; Region: HYR; pfam02494 411154004705 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 411154004706 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 411154004707 Tetratricopeptide repeat; Region: TPR_16; pfam13432 411154004708 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 411154004709 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 411154004710 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 411154004711 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 411154004712 ligand binding site [chemical binding]; other site 411154004713 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 411154004714 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 411154004715 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 411154004716 Catalytic dyad [active] 411154004717 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 411154004718 ribonuclease Z; Reviewed; Region: PRK00055 411154004719 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 411154004720 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 411154004721 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 411154004722 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 411154004723 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 411154004724 active site 411154004725 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 411154004726 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 411154004727 catalytic site [active] 411154004728 Ferritin-like domain; Region: Ferritin_2; pfam13668 411154004729 Ferritin-like domain; Region: Ferritin_2; pfam13668 411154004730 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 411154004731 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 411154004732 RNA binding site [nucleotide binding]; other site 411154004733 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 411154004734 RNA binding site [nucleotide binding]; other site 411154004735 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 411154004736 RNA binding site [nucleotide binding]; other site 411154004737 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 411154004738 RNA binding site [nucleotide binding]; other site 411154004739 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 411154004740 RNA binding site [nucleotide binding]; other site 411154004741 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 411154004742 RNA binding site [nucleotide binding]; other site 411154004743 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 411154004744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154004745 cytidylate kinase; Provisional; Region: cmk; PRK00023 411154004746 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 411154004747 CMP-binding site; other site 411154004748 The sites determining sugar specificity; other site 411154004749 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 411154004750 Found in ATP-dependent protease La (LON); Region: LON; smart00464 411154004751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154004752 Walker A motif; other site 411154004753 ATP binding site [chemical binding]; other site 411154004754 Walker B motif; other site 411154004755 arginine finger; other site 411154004756 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 411154004757 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 411154004758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 411154004759 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 411154004760 DNA binding residues [nucleotide binding] 411154004761 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 411154004762 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 411154004763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154004764 Peptidase family M48; Region: Peptidase_M48; pfam01435 411154004765 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 411154004766 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 411154004767 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 411154004768 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 411154004769 methionine sulfoxide reductase B; Provisional; Region: PRK05508 411154004770 methionine sulfoxide reductase B; Provisional; Region: PRK00222 411154004771 SelR domain; Region: SelR; pfam01641 411154004772 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 411154004773 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 411154004774 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 411154004775 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 411154004776 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 411154004777 Ligand Binding Site [chemical binding]; other site 411154004778 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 411154004779 Dehydroquinase class II; Region: DHquinase_II; pfam01220 411154004780 active site 411154004781 trimer interface [polypeptide binding]; other site 411154004782 dimer interface [polypeptide binding]; other site 411154004783 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 411154004784 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 411154004785 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 411154004786 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 411154004787 active site 411154004788 Int/Topo IB signature motif; other site 411154004789 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 411154004790 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 411154004791 active site 411154004792 catalytic tetrad [active] 411154004793 phosphodiesterase; Provisional; Region: PRK12704 411154004794 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 411154004795 Zn2+ binding site [ion binding]; other site 411154004796 Mg2+ binding site [ion binding]; other site 411154004797 Cell division protein ZapA; Region: ZapA; pfam05164 411154004798 flagellar capping protein; Validated; Region: fliD; PRK06798 411154004799 Peptidase family M23; Region: Peptidase_M23; pfam01551 411154004800 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 411154004801 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 411154004802 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 411154004803 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 411154004804 catalytic residue [active] 411154004805 Smr domain; Region: Smr; cl02619 411154004806 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 411154004807 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 411154004808 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 411154004809 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 411154004810 inhibitor-cofactor binding pocket; inhibition site 411154004811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154004812 catalytic residue [active] 411154004813 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 411154004814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154004815 S-adenosylmethionine binding site [chemical binding]; other site 411154004816 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 411154004817 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 411154004818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 411154004819 ZIP Zinc transporter; Region: Zip; pfam02535 411154004820 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 411154004821 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 411154004822 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 411154004823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 411154004824 Domain of unknown function (DUF4294); Region: DUF4294; pfam14127 411154004825 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 411154004826 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 411154004827 oligomer interface [polypeptide binding]; other site 411154004828 active site 411154004829 metal binding site [ion binding]; metal-binding site 411154004830 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 411154004831 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 411154004832 active site 411154004833 DNA binding site [nucleotide binding] 411154004834 Int/Topo IB signature motif; other site 411154004835 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 411154004836 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 411154004837 ligand binding site [chemical binding]; other site 411154004838 flexible hinge region; other site 411154004839 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 411154004840 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 411154004841 metal binding triad; other site 411154004842 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 411154004843 active site 411154004844 catalytic site [active] 411154004845 substrate binding site [chemical binding]; other site 411154004846 acetyl-CoA synthetase; Provisional; Region: PRK00174 411154004847 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 411154004848 active site 411154004849 CoA binding site [chemical binding]; other site 411154004850 acyl-activating enzyme (AAE) consensus motif; other site 411154004851 AMP binding site [chemical binding]; other site 411154004852 acetate binding site [chemical binding]; other site 411154004853 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 411154004854 ATP binding site [chemical binding]; other site 411154004855 active site 411154004856 substrate binding site [chemical binding]; other site 411154004857 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 411154004858 PhoH-like protein; Region: PhoH; pfam02562 411154004859 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 411154004860 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 411154004861 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 411154004862 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 411154004863 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 411154004864 DNA polymerase III subunit beta; Validated; Region: PRK05643 411154004865 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 411154004866 putative DNA binding surface [nucleotide binding]; other site 411154004867 dimer interface [polypeptide binding]; other site 411154004868 beta-clamp/clamp loader binding surface; other site 411154004869 beta-clamp/translesion DNA polymerase binding surface; other site 411154004870 Tic20-like protein; Region: Tic20; pfam09685 411154004871 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 411154004872 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 411154004873 trmE is a tRNA modification GTPase; Region: trmE; cd04164 411154004874 G1 box; other site 411154004875 GTP/Mg2+ binding site [chemical binding]; other site 411154004876 Switch I region; other site 411154004877 G2 box; other site 411154004878 Switch II region; other site 411154004879 G3 box; other site 411154004880 G4 box; other site 411154004881 G5 box; other site 411154004882 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 411154004883 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 411154004884 putative catalytic site [active] 411154004885 putative metal binding site [ion binding]; other site 411154004886 putative phosphate binding site [ion binding]; other site 411154004887 Predicted membrane protein [Function unknown]; Region: COG2323 411154004888 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 411154004889 classical (c) SDRs; Region: SDR_c; cd05233 411154004890 NAD(P) binding site [chemical binding]; other site 411154004891 active site 411154004892 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 411154004893 Predicted membrane protein [Function unknown]; Region: COG2323 411154004894 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 411154004895 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 411154004896 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 411154004897 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 411154004898 MgtC family; Region: MgtC; pfam02308 411154004899 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 411154004900 MarR family; Region: MarR; pfam01047 411154004901 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 411154004902 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 411154004903 putative NAD(P) binding site [chemical binding]; other site 411154004904 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 411154004905 NADH(P)-binding; Region: NAD_binding_10; pfam13460 411154004906 NAD(P) binding site [chemical binding]; other site 411154004907 putative active site [active] 411154004908 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 411154004909 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 411154004910 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 411154004911 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 411154004912 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 411154004913 Protein of unknown function DUF58; Region: DUF58; pfam01882 411154004914 MoxR-like ATPases [General function prediction only]; Region: COG0714 411154004915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154004916 Walker A motif; other site 411154004917 ATP binding site [chemical binding]; other site 411154004918 Walker B motif; other site 411154004919 arginine finger; other site 411154004920 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 411154004921 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 411154004922 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 411154004923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154004924 Walker A/P-loop; other site 411154004925 ATP binding site [chemical binding]; other site 411154004926 Q-loop/lid; other site 411154004927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154004928 ABC transporter signature motif; other site 411154004929 Walker B; other site 411154004930 D-loop; other site 411154004931 H-loop/switch region; other site 411154004932 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154004933 Q-loop/lid; other site 411154004934 ABC transporter signature motif; other site 411154004935 Walker B; other site 411154004936 D-loop; other site 411154004937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154004938 Walker A/P-loop; other site 411154004939 ATP binding site [chemical binding]; other site 411154004940 Q-loop/lid; other site 411154004941 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154004942 ABC transporter signature motif; other site 411154004943 Walker B; other site 411154004944 D-loop; other site 411154004945 H-loop/switch region; other site 411154004946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154004947 AAA domain; Region: AAA_21; pfam13304 411154004948 Walker A/P-loop; other site 411154004949 ATP binding site [chemical binding]; other site 411154004950 ABC transporter signature motif; other site 411154004951 Walker B; other site 411154004952 D-loop; other site 411154004953 H-loop/switch region; other site 411154004954 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 411154004955 CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704 411154004956 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 411154004957 active site 411154004958 catalytic triad [active] 411154004959 oxyanion hole [active] 411154004960 switch loop; other site 411154004961 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 411154004962 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 411154004963 Walker A/P-loop; other site 411154004964 ATP binding site [chemical binding]; other site 411154004965 Q-loop/lid; other site 411154004966 ABC transporter signature motif; other site 411154004967 Walker B; other site 411154004968 D-loop; other site 411154004969 H-loop/switch region; other site 411154004970 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 411154004971 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 411154004972 FtsX-like permease family; Region: FtsX; pfam02687 411154004973 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 411154004974 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 411154004975 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 411154004976 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 411154004977 active site 411154004978 Zn binding site [ion binding]; other site 411154004979 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 411154004980 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 411154004981 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 411154004982 pseudouridine synthase; Region: TIGR00093 411154004983 active site 411154004984 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 411154004985 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 411154004986 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 411154004987 heme binding pocket [chemical binding]; other site 411154004988 heme ligand [chemical binding]; other site 411154004989 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 411154004990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154004991 active site 411154004992 phosphorylation site [posttranslational modification] 411154004993 intermolecular recognition site; other site 411154004994 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 411154004995 GAF domain; Region: GAF; pfam01590 411154004996 Phytochrome region; Region: PHY; pfam00360 411154004997 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154004998 dimer interface [polypeptide binding]; other site 411154004999 phosphorylation site [posttranslational modification] 411154005000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154005001 ATP binding site [chemical binding]; other site 411154005002 Mg2+ binding site [ion binding]; other site 411154005003 G-X-G motif; other site 411154005004 CheB methylesterase; Region: CheB_methylest; pfam01339 411154005005 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 411154005006 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 411154005007 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 411154005008 PAS domain; Region: PAS_10; pfam13596 411154005009 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 411154005010 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 411154005011 putative active site [active] 411154005012 heme pocket [chemical binding]; other site 411154005013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154005014 dimer interface [polypeptide binding]; other site 411154005015 phosphorylation site [posttranslational modification] 411154005016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154005017 ATP binding site [chemical binding]; other site 411154005018 Mg2+ binding site [ion binding]; other site 411154005019 G-X-G motif; other site 411154005020 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 411154005021 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 411154005022 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 411154005023 nucleotide binding site [chemical binding]; other site 411154005024 homotetrameric interface [polypeptide binding]; other site 411154005025 putative phosphate binding site [ion binding]; other site 411154005026 putative allosteric binding site; other site 411154005027 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 411154005028 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 411154005029 putative catalytic cysteine [active] 411154005030 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 411154005031 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 411154005032 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 411154005033 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 411154005034 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 411154005035 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 411154005036 TrkA-N domain; Region: TrkA_N; pfam02254 411154005037 TrkA-C domain; Region: TrkA_C; pfam02080 411154005038 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 411154005039 ABC1 family; Region: ABC1; pfam03109 411154005040 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 411154005041 active site 411154005042 ATP binding site [chemical binding]; other site 411154005043 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 411154005044 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 411154005045 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 411154005046 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 411154005047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154005048 catalytic residue [active] 411154005049 homoserine kinase; Provisional; Region: PRK01212 411154005050 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 411154005051 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 411154005052 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 411154005053 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 411154005054 putative catalytic residues [active] 411154005055 putative nucleotide binding site [chemical binding]; other site 411154005056 putative aspartate binding site [chemical binding]; other site 411154005057 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 411154005058 dimer interface [polypeptide binding]; other site 411154005059 putative threonine allosteric regulatory site; other site 411154005060 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 411154005061 putative threonine allosteric regulatory site; other site 411154005062 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 411154005063 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 411154005064 EamA-like transporter family; Region: EamA; pfam00892 411154005065 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 411154005066 HSP70 interaction site [polypeptide binding]; other site 411154005067 KTSC domain; Region: KTSC; pfam13619 411154005068 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 411154005069 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 411154005070 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 411154005071 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 411154005072 metal ion-dependent adhesion site (MIDAS); other site 411154005073 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 411154005074 putative catalytic site [active] 411154005075 putative metal binding site [ion binding]; other site 411154005076 putative phosphate binding site [ion binding]; other site 411154005077 Response regulator receiver domain; Region: Response_reg; pfam00072 411154005078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154005079 active site 411154005080 phosphorylation site [posttranslational modification] 411154005081 intermolecular recognition site; other site 411154005082 dimerization interface [polypeptide binding]; other site 411154005083 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 411154005084 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 411154005085 putative active site [active] 411154005086 heme pocket [chemical binding]; other site 411154005087 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 411154005088 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 411154005089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 411154005090 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 411154005091 putative active site [active] 411154005092 heme pocket [chemical binding]; other site 411154005093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 411154005094 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 411154005095 putative active site [active] 411154005096 heme pocket [chemical binding]; other site 411154005097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 411154005098 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 411154005099 putative active site [active] 411154005100 heme pocket [chemical binding]; other site 411154005101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 411154005102 putative active site [active] 411154005103 heme pocket [chemical binding]; other site 411154005104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154005105 phosphorylation site [posttranslational modification] 411154005106 dimer interface [polypeptide binding]; other site 411154005107 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 411154005108 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 411154005109 Chain length determinant protein; Region: Wzz; cl15801 411154005110 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 411154005111 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 411154005112 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 411154005113 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 411154005114 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 411154005115 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 411154005116 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 411154005117 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 411154005118 NAD(P) binding site [chemical binding]; other site 411154005119 homodimer interface [polypeptide binding]; other site 411154005120 substrate binding site [chemical binding]; other site 411154005121 active site 411154005122 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 411154005123 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 411154005124 inhibitor-cofactor binding pocket; inhibition site 411154005125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154005126 catalytic residue [active] 411154005127 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 411154005128 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 411154005129 putative trimer interface [polypeptide binding]; other site 411154005130 putative CoA binding site [chemical binding]; other site 411154005131 Bacterial sugar transferase; Region: Bac_transf; pfam02397 411154005132 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 411154005133 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 411154005134 putative ADP-binding pocket [chemical binding]; other site 411154005135 Homeodomain-like domain; Region: HTH_23; cl17451 411154005136 putative transposase OrfB; Reviewed; Region: PHA02517 411154005137 HTH-like domain; Region: HTH_21; pfam13276 411154005138 Integrase core domain; Region: rve; pfam00665 411154005139 Integrase core domain; Region: rve_3; pfam13683 411154005140 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 411154005141 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 411154005142 putative transposase OrfB; Reviewed; Region: PHA02517 411154005143 HTH-like domain; Region: HTH_21; pfam13276 411154005144 Integrase core domain; Region: rve; pfam00665 411154005145 Integrase core domain; Region: rve_3; pfam13683 411154005146 Homeodomain-like domain; Region: HTH_23; cl17451 411154005147 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 411154005148 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 411154005149 active site 411154005150 dimer interface [polypeptide binding]; other site 411154005151 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 411154005152 Ligand Binding Site [chemical binding]; other site 411154005153 Molecular Tunnel; other site 411154005154 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u5; cd10929 411154005155 putative active site [active] 411154005156 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 411154005157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 411154005158 Coenzyme A binding pocket [chemical binding]; other site 411154005159 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 411154005160 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 411154005161 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 411154005162 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 411154005163 putative ADP-binding pocket [chemical binding]; other site 411154005164 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 411154005165 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 411154005166 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 411154005167 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 411154005168 putative active site [active] 411154005169 putative metal binding site [ion binding]; other site 411154005170 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 411154005171 Ligand Binding Site [chemical binding]; other site 411154005172 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 411154005173 Ligand Binding Site [chemical binding]; other site 411154005174 HTH-like domain; Region: HTH_21; pfam13276 411154005175 Transposase; Region: DDE_Tnp_ISL3; pfam01610 411154005176 hypothetical protein; Provisional; Region: PRK07588 411154005177 pseudaminic acid synthase; Region: PseI; TIGR03586 411154005178 NeuB family; Region: NeuB; pfam03102 411154005179 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 411154005180 NeuB binding interface [polypeptide binding]; other site 411154005181 putative substrate binding site [chemical binding]; other site 411154005182 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 411154005183 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_1; cd08821 411154005184 putative active site [active] 411154005185 putative substrate binding site [chemical binding]; other site 411154005186 putative cosubstrate binding site; other site 411154005187 catalytic site [active] 411154005188 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 411154005189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 411154005190 Coenzyme A binding pocket [chemical binding]; other site 411154005191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 411154005192 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 411154005193 dimer interaction site [polypeptide binding]; other site 411154005194 substrate-binding tunnel; other site 411154005195 active site 411154005196 catalytic site [active] 411154005197 substrate binding site [chemical binding]; other site 411154005198 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 411154005199 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 411154005200 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 411154005201 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 411154005202 ligand binding site; other site 411154005203 tetramer interface; other site 411154005204 flagellin modification protein A; Provisional; Region: PRK09186 411154005205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 411154005206 NAD(P) binding site [chemical binding]; other site 411154005207 active site 411154005208 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 411154005209 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 411154005210 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 411154005211 active site 411154005212 catalytic tetrad [active] 411154005213 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 411154005214 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 411154005215 inhibitor-cofactor binding pocket; inhibition site 411154005216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154005217 catalytic residue [active] 411154005218 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 411154005219 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 411154005220 NAD(P) binding site [chemical binding]; other site 411154005221 homodimer interface [polypeptide binding]; other site 411154005222 substrate binding site [chemical binding]; other site 411154005223 active site 411154005224 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 411154005225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154005226 Walker A/P-loop; other site 411154005227 ATP binding site [chemical binding]; other site 411154005228 Q-loop/lid; other site 411154005229 ABC transporter signature motif; other site 411154005230 Walker B; other site 411154005231 D-loop; other site 411154005232 H-loop/switch region; other site 411154005233 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 411154005234 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 411154005235 Probable Catalytic site; other site 411154005236 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 411154005237 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 411154005238 active site 411154005239 hypothetical protein; Provisional; Region: PRK07579 411154005240 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 411154005241 active site 411154005242 cosubstrate binding site; other site 411154005243 substrate binding site [chemical binding]; other site 411154005244 catalytic site [active] 411154005245 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 411154005246 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 411154005247 inhibitor-cofactor binding pocket; inhibition site 411154005248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154005249 catalytic residue [active] 411154005250 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 411154005251 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 411154005252 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 411154005253 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 411154005254 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 411154005255 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 411154005256 substrate binding site; other site 411154005257 tetramer interface; other site 411154005258 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 411154005259 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 411154005260 NAD binding site [chemical binding]; other site 411154005261 substrate binding site [chemical binding]; other site 411154005262 homodimer interface [polypeptide binding]; other site 411154005263 active site 411154005264 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 411154005265 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 411154005266 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 411154005267 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 411154005268 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 411154005269 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 411154005270 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 411154005271 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 411154005272 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 411154005273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 411154005274 Coenzyme A binding pocket [chemical binding]; other site 411154005275 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 411154005276 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 411154005277 NAD binding site [chemical binding]; other site 411154005278 substrate binding site [chemical binding]; other site 411154005279 homodimer interface [polypeptide binding]; other site 411154005280 active site 411154005281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 411154005282 Transcriptional regulators [Transcription]; Region: PurR; COG1609 411154005283 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 411154005284 DNA binding site [nucleotide binding] 411154005285 domain linker motif; other site 411154005286 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 411154005287 dimerization interface [polypeptide binding]; other site 411154005288 ligand binding site [chemical binding]; other site 411154005289 Protein of unknown function, DUF393; Region: DUF393; pfam04134 411154005290 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 411154005291 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 411154005292 dimerization interface [polypeptide binding]; other site 411154005293 DPS ferroxidase diiron center [ion binding]; other site 411154005294 ion pore; other site 411154005295 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 411154005296 Mechanosensitive ion channel; Region: MS_channel; pfam00924 411154005297 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 411154005298 active site 411154005299 metal binding site [ion binding]; metal-binding site 411154005300 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 411154005301 Surface antigen; Region: Bac_surface_Ag; pfam01103 411154005302 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 411154005303 Zn2+ binding site [ion binding]; other site 411154005304 Mg2+ binding site [ion binding]; other site 411154005305 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 411154005306 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 411154005307 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 411154005308 catalytic residues [active] 411154005309 Uncharacterized conserved protein [Function unknown]; Region: COG2968 411154005310 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 411154005311 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 411154005312 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 411154005313 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 411154005314 putative acyl-acceptor binding pocket; other site 411154005315 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 411154005316 This PGM-like (phosphoglucomutase-like) domain is located C-terminal to a mannose-1-phosphate guanyltransferase domain in a protein of unknown function that is found in both prokaryotes and eukaryotes. This domain belongs to the alpha-D-phosphohexomutase...; Region: PGM_like4; cd05803 411154005317 active site 411154005318 substrate binding site [chemical binding]; other site 411154005319 metal binding site [ion binding]; metal-binding site 411154005320 Protein of unknown function, DUF479; Region: DUF479; cl01203 411154005321 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 411154005322 Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280 411154005323 active site 411154005324 Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280 411154005325 active site 411154005326 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 411154005327 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 411154005328 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 411154005329 DNA binding residues [nucleotide binding] 411154005330 dimerization interface [polypeptide binding]; other site 411154005331 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 411154005332 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 411154005333 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 411154005334 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 411154005335 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 411154005336 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 411154005337 Zn binding site [ion binding]; other site 411154005338 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 411154005339 tetramer interface [polypeptide binding]; other site 411154005340 TPP-binding site [chemical binding]; other site 411154005341 heterodimer interface [polypeptide binding]; other site 411154005342 phosphorylation loop region [posttranslational modification] 411154005343 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 411154005344 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 411154005345 PYR/PP interface [polypeptide binding]; other site 411154005346 dimer interface [polypeptide binding]; other site 411154005347 TPP binding site [chemical binding]; other site 411154005348 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 411154005349 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 411154005350 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 411154005351 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 411154005352 substrate binding site [chemical binding]; other site 411154005353 oxyanion hole (OAH) forming residues; other site 411154005354 trimer interface [polypeptide binding]; other site 411154005355 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 411154005356 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 411154005357 S1 domain; Region: S1_2; pfam13509 411154005358 S1 domain; Region: S1_2; pfam13509 411154005359 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 411154005360 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 411154005361 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 411154005362 dimer interface [polypeptide binding]; other site 411154005363 tetramer interface [polypeptide binding]; other site 411154005364 PYR/PP interface [polypeptide binding]; other site 411154005365 TPP binding site [chemical binding]; other site 411154005366 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 411154005367 TPP-binding site [chemical binding]; other site 411154005368 chorismate binding enzyme; Region: Chorismate_bind; cl10555 411154005369 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 411154005370 CoenzymeA binding site [chemical binding]; other site 411154005371 subunit interaction site [polypeptide binding]; other site 411154005372 PHB binding site; other site 411154005373 Predicted esterase [General function prediction only]; Region: COG0400 411154005374 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 411154005375 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 411154005376 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 411154005377 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 411154005378 Coenzyme A binding pocket [chemical binding]; other site 411154005379 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 411154005380 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 411154005381 nucleotide binding site [chemical binding]; other site 411154005382 NEF interaction site [polypeptide binding]; other site 411154005383 SBD interface [polypeptide binding]; other site 411154005384 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 411154005385 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 411154005386 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 411154005387 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 411154005388 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 411154005389 putative NAD(P) binding site [chemical binding]; other site 411154005390 putative substrate binding site [chemical binding]; other site 411154005391 catalytic Zn binding site [ion binding]; other site 411154005392 structural Zn binding site [ion binding]; other site 411154005393 Uncharacterized conserved protein [Function unknown]; Region: COG1262 411154005394 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 411154005395 Beta-lactamase; Region: Beta-lactamase; pfam00144 411154005396 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 411154005397 radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261 411154005398 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 411154005399 active site 411154005400 oligomerization interface [polypeptide binding]; other site 411154005401 metal binding site [ion binding]; metal-binding site 411154005402 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 411154005403 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 411154005404 active site 411154005405 Predicted metalloprotease [General function prediction only]; Region: COG2321 411154005406 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 411154005407 EamA-like transporter family; Region: EamA; pfam00892 411154005408 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 411154005409 EamA-like transporter family; Region: EamA; pfam00892 411154005410 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 411154005411 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 411154005412 active site 411154005413 catalytic residues [active] 411154005414 metal binding site [ion binding]; metal-binding site 411154005415 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 411154005416 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 411154005417 substrate binding site [chemical binding]; other site 411154005418 ligand binding site [chemical binding]; other site 411154005419 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 411154005420 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 411154005421 substrate binding site [chemical binding]; other site 411154005422 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 411154005423 tartrate dehydrogenase; Region: TTC; TIGR02089 411154005424 argininosuccinate lyase; Provisional; Region: PRK00855 411154005425 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 411154005426 active sites [active] 411154005427 tetramer interface [polypeptide binding]; other site 411154005428 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 411154005429 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 411154005430 metal binding site [ion binding]; metal-binding site 411154005431 dimer interface [polypeptide binding]; other site 411154005432 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 411154005433 nucleotide binding site [chemical binding]; other site 411154005434 N-acetyl-L-glutamate binding site [chemical binding]; other site 411154005435 HPP family; Region: HPP; pfam04982 411154005436 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 411154005437 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 411154005438 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 411154005439 acetylornithine aminotransferase; Provisional; Region: PRK02627 411154005440 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 411154005441 inhibitor-cofactor binding pocket; inhibition site 411154005442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154005443 catalytic residue [active] 411154005444 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 411154005445 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 411154005446 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 411154005447 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 411154005448 argininosuccinate synthase; Provisional; Region: PRK13820 411154005449 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 411154005450 Ligand Binding Site [chemical binding]; other site 411154005451 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 411154005452 Coenzyme A binding pocket [chemical binding]; other site 411154005453 threonine dehydratase; Validated; Region: PRK08639 411154005454 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 411154005455 tetramer interface [polypeptide binding]; other site 411154005456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154005457 catalytic residue [active] 411154005458 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 411154005459 putative Ile/Val binding site [chemical binding]; other site 411154005460 ketol-acid reductoisomerase; Validated; Region: PRK05225 411154005461 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 411154005462 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 411154005463 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 411154005464 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 411154005465 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 411154005466 putative valine binding site [chemical binding]; other site 411154005467 dimer interface [polypeptide binding]; other site 411154005468 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 411154005469 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 411154005470 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 411154005471 PYR/PP interface [polypeptide binding]; other site 411154005472 dimer interface [polypeptide binding]; other site 411154005473 TPP binding site [chemical binding]; other site 411154005474 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 411154005475 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 411154005476 TPP-binding site [chemical binding]; other site 411154005477 dimer interface [polypeptide binding]; other site 411154005478 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 411154005479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 411154005480 Coenzyme A binding pocket [chemical binding]; other site 411154005481 Predicted amidohydrolase [General function prediction only]; Region: COG0388 411154005482 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 411154005483 putative active site [active] 411154005484 catalytic triad [active] 411154005485 putative dimer interface [polypeptide binding]; other site 411154005486 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 411154005487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154005488 active site 411154005489 phosphorylation site [posttranslational modification] 411154005490 intermolecular recognition site; other site 411154005491 dimerization interface [polypeptide binding]; other site 411154005492 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 411154005493 DNA binding residues [nucleotide binding] 411154005494 dimerization interface [polypeptide binding]; other site 411154005495 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 411154005496 Histidine kinase; Region: HisKA_3; pfam07730 411154005497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154005498 ATP binding site [chemical binding]; other site 411154005499 Mg2+ binding site [ion binding]; other site 411154005500 G-X-G motif; other site 411154005501 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 411154005502 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 411154005503 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 411154005504 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801 411154005505 putative active site [active] 411154005506 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 411154005507 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 411154005508 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 411154005509 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 411154005510 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 411154005511 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 411154005512 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 411154005513 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 411154005514 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154005515 dimer interface [polypeptide binding]; other site 411154005516 phosphorylation site [posttranslational modification] 411154005517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154005518 ATP binding site [chemical binding]; other site 411154005519 Mg2+ binding site [ion binding]; other site 411154005520 G-X-G motif; other site 411154005521 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 411154005522 nucleotide binding site [chemical binding]; other site 411154005523 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 411154005524 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 411154005525 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 411154005526 6-phosphofructokinase; Provisional; Region: PRK03202 411154005527 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 411154005528 active site 411154005529 ADP/pyrophosphate binding site [chemical binding]; other site 411154005530 dimerization interface [polypeptide binding]; other site 411154005531 allosteric effector site; other site 411154005532 fructose-1,6-bisphosphate binding site; other site 411154005533 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 411154005534 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 411154005535 active site 411154005536 catalytic site [active] 411154005537 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 411154005538 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 411154005539 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 411154005540 Ca binding site [ion binding]; other site 411154005541 active site 411154005542 homodimer interface [polypeptide binding]; other site 411154005543 catalytic site [active] 411154005544 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 411154005545 maltose phosphorylase; Provisional; Region: PRK13807 411154005546 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 411154005547 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 411154005548 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 411154005549 beta-phosphoglucomutase; Region: bPGM; TIGR01990 411154005550 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 411154005551 Major Facilitator Superfamily; Region: MFS_1; pfam07690 411154005552 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 411154005553 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 411154005554 Transcriptional regulators [Transcription]; Region: PurR; COG1609 411154005555 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 411154005556 DNA binding site [nucleotide binding] 411154005557 domain linker motif; other site 411154005558 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 411154005559 dimerization interface [polypeptide binding]; other site 411154005560 ligand binding site [chemical binding]; other site 411154005561 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 411154005562 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154005563 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 411154005564 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154005565 starch binding outer membrane protein SusD; Region: SusD; cd08977 411154005566 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 411154005567 SusE outer membrane protein; Region: SusE; pfam14292 411154005568 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 411154005569 starch binding site [chemical binding]; other site 411154005570 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 411154005571 Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314 411154005572 active site 411154005573 Ca binding site [ion binding]; other site 411154005574 catalytic site [active] 411154005575 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 411154005576 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 411154005577 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 411154005578 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 411154005579 active site 411154005580 dimer interface [polypeptide binding]; other site 411154005581 effector binding site; other site 411154005582 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 411154005583 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 411154005584 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 411154005585 nudix motif; other site 411154005586 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 411154005587 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 411154005588 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 411154005589 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 411154005590 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 411154005591 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 411154005592 dimer interface [polypeptide binding]; other site 411154005593 active site 411154005594 Transcriptional regulators [Transcription]; Region: PurR; COG1609 411154005595 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 411154005596 DNA binding site [nucleotide binding] 411154005597 domain linker motif; other site 411154005598 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 411154005599 dimerization interface [polypeptide binding]; other site 411154005600 ligand binding site [chemical binding]; other site 411154005601 putative transporter; Provisional; Region: PRK10484 411154005602 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 411154005603 Na binding site [ion binding]; other site 411154005604 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 411154005605 active site 411154005606 catalytic residues [active] 411154005607 Treponema clustered lipoprotein (Trep_dent_lipo); Region: Trep_dent_lipo; cl09912 411154005608 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 411154005609 Predicted acyl esterases [General function prediction only]; Region: COG2936 411154005610 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 411154005611 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 411154005612 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 411154005613 Ligand Binding Site [chemical binding]; other site 411154005614 TilS substrate C-terminal domain; Region: TilS_C; smart00977 411154005615 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 411154005616 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 411154005617 Predicted flavoprotein [General function prediction only]; Region: COG0431 411154005618 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 411154005619 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 411154005620 active site 411154005621 catalytic residues [active] 411154005622 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 411154005623 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 411154005624 ATP binding site [chemical binding]; other site 411154005625 Mg++ binding site [ion binding]; other site 411154005626 motif III; other site 411154005627 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 411154005628 nucleotide binding region [chemical binding]; other site 411154005629 ATP-binding site [chemical binding]; other site 411154005630 ORF6N domain; Region: ORF6N; pfam10543 411154005631 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 411154005632 Beta-lactamase; Region: Beta-lactamase; pfam00144 411154005633 Histidine kinase; Region: His_kinase; pfam06580 411154005634 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 411154005635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154005636 active site 411154005637 phosphorylation site [posttranslational modification] 411154005638 intermolecular recognition site; other site 411154005639 dimerization interface [polypeptide binding]; other site 411154005640 LytTr DNA-binding domain; Region: LytTR; smart00850 411154005641 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 411154005642 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 411154005643 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 411154005644 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 411154005645 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 411154005646 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 411154005647 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 411154005648 NAD(P) binding site [chemical binding]; other site 411154005649 catalytic residues [active] 411154005650 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 411154005651 active site 411154005652 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 411154005653 biotin carboxylase-like protein; Validated; Region: PRK06524 411154005654 ATP-grasp domain; Region: ATP-grasp_4; cl17255 411154005655 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 411154005656 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 411154005657 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 411154005658 catalytic residue [active] 411154005659 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 411154005660 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 411154005661 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 411154005662 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 411154005663 Predicted amidohydrolase [General function prediction only]; Region: COG0388 411154005664 active site 411154005665 catalytic triad [active] 411154005666 dimer interface [polypeptide binding]; other site 411154005667 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 411154005668 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 411154005669 inhibitor-cofactor binding pocket; inhibition site 411154005670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154005671 catalytic residue [active] 411154005672 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 411154005673 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 411154005674 putative DNA binding site [nucleotide binding]; other site 411154005675 putative Zn2+ binding site [ion binding]; other site 411154005676 AsnC family; Region: AsnC_trans_reg; pfam01037 411154005677 methionine gamma-lyase; Region: PLN02242 411154005678 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 411154005679 homodimer interface [polypeptide binding]; other site 411154005680 substrate-cofactor binding pocket; other site 411154005681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154005682 catalytic residue [active] 411154005683 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 411154005684 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 411154005685 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 411154005686 dimer interface [polypeptide binding]; other site 411154005687 decamer (pentamer of dimers) interface [polypeptide binding]; other site 411154005688 catalytic triad [active] 411154005689 peroxidatic and resolving cysteines [active] 411154005690 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 411154005691 catalytic residues [active] 411154005692 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 411154005693 dimer interface [polypeptide binding]; other site 411154005694 catalytic triad [active] 411154005695 peroxidatic and resolving cysteines [active] 411154005696 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 411154005697 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 411154005698 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 411154005699 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 411154005700 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 411154005701 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 411154005702 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 411154005703 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 411154005704 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 411154005705 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 411154005706 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 411154005707 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 411154005708 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 411154005709 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 411154005710 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 411154005711 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 411154005712 dimerization interface [polypeptide binding]; other site 411154005713 active site 411154005714 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 411154005715 dimer interface [polypeptide binding]; other site 411154005716 FMN binding site [chemical binding]; other site 411154005717 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 411154005718 putative active site [active] 411154005719 Membrane protein of unknown function; Region: DUF360; pfam04020 411154005720 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 411154005721 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 411154005722 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 411154005723 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 411154005724 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154005725 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 411154005726 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 411154005727 N-terminal plug; other site 411154005728 ligand-binding site [chemical binding]; other site 411154005729 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 411154005730 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 411154005731 active site 411154005732 motif I; other site 411154005733 motif II; other site 411154005734 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 411154005735 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 411154005736 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 411154005737 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 411154005738 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 411154005739 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 411154005740 dimerization interface [polypeptide binding]; other site 411154005741 putative DNA binding site [nucleotide binding]; other site 411154005742 putative Zn2+ binding site [ion binding]; other site 411154005743 Low molecular weight phosphatase family; Region: LMWPc; cl00105 411154005744 active site 411154005745 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 411154005746 arsenical-resistance protein; Region: acr3; TIGR00832 411154005747 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 411154005748 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 411154005749 putative metal binding site [ion binding]; other site 411154005750 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 411154005751 putative hydrophobic ligand binding site [chemical binding]; other site 411154005752 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 411154005753 Putative esterase; Region: Esterase; pfam00756 411154005754 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 411154005755 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 411154005756 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 411154005757 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 411154005758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154005759 Major Facilitator Superfamily; Region: MFS_1; pfam07690 411154005760 putative substrate translocation pore; other site 411154005761 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 411154005762 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 411154005763 putative NAD(P) binding site [chemical binding]; other site 411154005764 homodimer interface [polypeptide binding]; other site 411154005765 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 411154005766 GH3 auxin-responsive promoter; Region: GH3; pfam03321 411154005767 Halocarboxylic acid dehydrogenase DehI; Region: DehI; pfam10778 411154005768 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 411154005769 sensor protein ZraS; Provisional; Region: PRK10364 411154005770 Response regulator receiver domain; Region: Response_reg; pfam00072 411154005771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154005772 active site 411154005773 phosphorylation site [posttranslational modification] 411154005774 intermolecular recognition site; other site 411154005775 dimerization interface [polypeptide binding]; other site 411154005776 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 411154005777 CTP synthetase; Validated; Region: pyrG; PRK05380 411154005778 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 411154005779 Catalytic site [active] 411154005780 active site 411154005781 UTP binding site [chemical binding]; other site 411154005782 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 411154005783 active site 411154005784 putative oxyanion hole; other site 411154005785 catalytic triad [active] 411154005786 membrane protein insertase; Provisional; Region: PRK01318 411154005787 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 411154005788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 411154005789 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 411154005790 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 411154005791 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 411154005792 Peptidase S8 family domain, uncharacterized subfamily 9; Region: Peptidases_S8_9; cd07493 411154005793 active site 411154005794 catalytic triad [active] 411154005795 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 411154005796 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 411154005797 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 411154005798 FMN binding site [chemical binding]; other site 411154005799 substrate binding site [chemical binding]; other site 411154005800 putative catalytic residue [active] 411154005801 OsmC-like protein; Region: OsmC; pfam02566 411154005802 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 411154005803 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 411154005804 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 411154005805 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 411154005806 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 411154005807 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 411154005808 ligand binding site [chemical binding]; other site 411154005809 GMP synthase; Reviewed; Region: guaA; PRK00074 411154005810 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 411154005811 AMP/PPi binding site [chemical binding]; other site 411154005812 candidate oxyanion hole; other site 411154005813 catalytic triad [active] 411154005814 potential glutamine specificity residues [chemical binding]; other site 411154005815 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 411154005816 ATP Binding subdomain [chemical binding]; other site 411154005817 Ligand Binding sites [chemical binding]; other site 411154005818 Dimerization subdomain; other site 411154005819 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 411154005820 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 411154005821 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 411154005822 catalytic residue [active] 411154005823 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 411154005824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 411154005825 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 411154005826 putative active site [active] 411154005827 Zn binding site [ion binding]; other site 411154005828 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 411154005829 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 411154005830 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 411154005831 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 411154005832 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 411154005833 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 411154005834 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 411154005835 Uncharacterized conserved protein [Function unknown]; Region: COG0398 411154005836 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 411154005837 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 411154005838 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 411154005839 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 411154005840 FeS/SAM binding site; other site 411154005841 amidase; Provisional; Region: PRK06707 411154005842 Amidase; Region: Amidase; cl11426 411154005843 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 411154005844 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 411154005845 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 411154005846 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 411154005847 ribosomal protein L33; Region: rpl33; CHL00104 411154005848 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 411154005849 competence damage-inducible protein A; Provisional; Region: PRK00549 411154005850 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 411154005851 putative MPT binding site; other site 411154005852 Competence-damaged protein; Region: CinA; pfam02464 411154005853 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 411154005854 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 411154005855 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 411154005856 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 411154005857 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 411154005858 active site 411154005859 catalytic site [active] 411154005860 substrate binding site [chemical binding]; other site 411154005861 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 411154005862 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 411154005863 E3 interaction surface; other site 411154005864 lipoyl attachment site [posttranslational modification]; other site 411154005865 e3 binding domain; Region: E3_binding; pfam02817 411154005866 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 411154005867 recombination protein RecR; Reviewed; Region: recR; PRK00076 411154005868 RecR protein; Region: RecR; pfam02132 411154005869 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 411154005870 putative active site [active] 411154005871 putative metal-binding site [ion binding]; other site 411154005872 tetramer interface [polypeptide binding]; other site 411154005873 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 411154005874 Na binding site [ion binding]; other site 411154005875 CoA binding domain; Region: CoA_binding_2; pfam13380 411154005876 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154005877 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 411154005878 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154005879 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 411154005880 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 411154005881 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 411154005882 ABC transporter; Region: ABC_tran_2; pfam12848 411154005883 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 411154005884 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 411154005885 active site 411154005886 intersubunit interactions; other site 411154005887 catalytic residue [active] 411154005888 short chain dehydrogenase; Provisional; Region: PRK06179 411154005889 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 411154005890 NADP binding site [chemical binding]; other site 411154005891 active site 411154005892 steroid binding site; other site 411154005893 Glutamine cyclotransferase; Region: Glu_cyclase_2; pfam05096 411154005894 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 411154005895 active site 411154005896 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 411154005897 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 411154005898 dimer interface [polypeptide binding]; other site 411154005899 active site 411154005900 glycine-pyridoxal phosphate binding site [chemical binding]; other site 411154005901 folate binding site [chemical binding]; other site 411154005902 fumarylacetoacetase; Region: PLN02856 411154005903 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 411154005904 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 411154005905 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 411154005906 catalytic residues [active] 411154005907 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 411154005908 Clp amino terminal domain; Region: Clp_N; pfam02861 411154005909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154005910 Walker A motif; other site 411154005911 ATP binding site [chemical binding]; other site 411154005912 Walker B motif; other site 411154005913 arginine finger; other site 411154005914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154005915 Walker A motif; other site 411154005916 ATP binding site [chemical binding]; other site 411154005917 Walker B motif; other site 411154005918 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 411154005919 CsbD-like; Region: CsbD; cl17424 411154005920 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 411154005921 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 411154005922 catalytic core [active] 411154005923 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 411154005924 SmpB-tmRNA interface; other site 411154005925 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154005926 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 411154005927 active site 411154005928 catalytic residues [active] 411154005929 metal binding site [ion binding]; metal-binding site 411154005930 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 411154005931 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 411154005932 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 411154005933 trimer interface [polypeptide binding]; other site 411154005934 active site 411154005935 substrate binding site [chemical binding]; other site 411154005936 CoA binding site [chemical binding]; other site 411154005937 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 411154005938 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 411154005939 putative active site [active] 411154005940 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 411154005941 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 411154005942 Substrate binding site; other site 411154005943 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 411154005944 metal-binding site 411154005945 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 411154005946 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 411154005947 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 411154005948 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 411154005949 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 411154005950 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 411154005951 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 411154005952 active site 411154005953 NTP binding site [chemical binding]; other site 411154005954 metal binding triad [ion binding]; metal-binding site 411154005955 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 411154005956 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 411154005957 Zn2+ binding site [ion binding]; other site 411154005958 Mg2+ binding site [ion binding]; other site 411154005959 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 411154005960 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 411154005961 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 411154005962 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 411154005963 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 411154005964 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 411154005965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154005966 Walker A/P-loop; other site 411154005967 ATP binding site [chemical binding]; other site 411154005968 Q-loop/lid; other site 411154005969 ABC transporter signature motif; other site 411154005970 Walker B; other site 411154005971 D-loop; other site 411154005972 H-loop/switch region; other site 411154005973 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 411154005974 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 411154005975 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 411154005976 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 411154005977 excinuclease ABC subunit B; Provisional; Region: PRK05298 411154005978 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 411154005979 ATP binding site [chemical binding]; other site 411154005980 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 411154005981 nucleotide binding region [chemical binding]; other site 411154005982 ATP-binding site [chemical binding]; other site 411154005983 Ultra-violet resistance protein B; Region: UvrB; pfam12344 411154005984 UvrB/uvrC motif; Region: UVR; pfam02151 411154005985 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 411154005986 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 411154005987 putative dimer interface [polypeptide binding]; other site 411154005988 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 411154005989 Predicted membrane protein [Function unknown]; Region: COG4325 411154005990 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 411154005991 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 411154005992 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 411154005993 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 411154005994 ABC transporter; Region: ABC_tran_2; pfam12848 411154005995 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 411154005996 DinB superfamily; Region: DinB_2; pfam12867 411154005997 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 411154005998 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 411154005999 Zn binding site [ion binding]; other site 411154006000 DoxX; Region: DoxX; pfam07681 411154006001 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 411154006002 active site 411154006003 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 411154006004 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 411154006005 acyl-activating enzyme (AAE) consensus motif; other site 411154006006 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 411154006007 AMP binding site [chemical binding]; other site 411154006008 active site 411154006009 CoA binding site [chemical binding]; other site 411154006010 Uncharacterized conserved protein [Function unknown]; Region: COG5276 411154006011 CAAX protease self-immunity; Region: Abi; pfam02517 411154006012 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 411154006013 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 411154006014 active site 411154006015 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 411154006016 four helix bundle protein; Region: TIGR02436 411154006017 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 411154006018 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 411154006019 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 411154006020 UbiA prenyltransferase family; Region: UbiA; pfam01040 411154006021 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 411154006022 DNA polymerase III, delta subunit; Region: holA; TIGR01128 411154006023 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 411154006024 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 411154006025 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 411154006026 Probable Catalytic site; other site 411154006027 metal-binding site 411154006028 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 411154006029 ligand binding site [chemical binding]; other site 411154006030 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 411154006031 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 411154006032 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 411154006033 Part of AAA domain; Region: AAA_19; pfam13245 411154006034 Family description; Region: UvrD_C_2; pfam13538 411154006035 DsrE/DsrF-like family; Region: DrsE; pfam02635 411154006036 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 411154006037 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 411154006038 metal binding site [ion binding]; metal-binding site 411154006039 putative dimer interface [polypeptide binding]; other site 411154006040 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 411154006041 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 411154006042 active site 411154006043 FMN binding site [chemical binding]; other site 411154006044 substrate binding site [chemical binding]; other site 411154006045 3Fe-4S cluster binding site [ion binding]; other site 411154006046 Patatin-like phospholipase; Region: Patatin; pfam01734 411154006047 active site 411154006048 nucleophile elbow; other site 411154006049 Patatin-like phospholipase; Region: Patatin; pfam01734 411154006050 active site 411154006051 nucleophile elbow; other site 411154006052 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 411154006053 Peptidase family M1; Region: Peptidase_M1; pfam01433 411154006054 Zn binding site [ion binding]; other site 411154006055 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 411154006056 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 411154006057 generic binding surface II; other site 411154006058 ssDNA binding site; other site 411154006059 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 411154006060 ATP binding site [chemical binding]; other site 411154006061 putative Mg++ binding site [ion binding]; other site 411154006062 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 411154006063 nucleotide binding region [chemical binding]; other site 411154006064 ATP-binding site [chemical binding]; other site 411154006065 Tetratricopeptide repeat; Region: TPR_12; pfam13424 411154006066 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 411154006067 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 411154006068 putative tRNA-binding site [nucleotide binding]; other site 411154006069 B3/4 domain; Region: B3_4; pfam03483 411154006070 tRNA synthetase B5 domain; Region: B5; pfam03484 411154006071 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 411154006072 dimer interface [polypeptide binding]; other site 411154006073 motif 1; other site 411154006074 motif 3; other site 411154006075 motif 2; other site 411154006076 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 411154006077 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 411154006078 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 411154006079 Fasciclin domain; Region: Fasciclin; pfam02469 411154006080 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 411154006081 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 411154006082 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 411154006083 dimer interface [polypeptide binding]; other site 411154006084 active site 411154006085 CoA binding pocket [chemical binding]; other site 411154006086 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 411154006087 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 411154006088 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 411154006089 ABC1 family; Region: ABC1; cl17513 411154006090 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 411154006091 active site 411154006092 ATP binding site [chemical binding]; other site 411154006093 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 411154006094 heat shock protein 90; Provisional; Region: PRK05218 411154006095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154006096 ATP binding site [chemical binding]; other site 411154006097 Mg2+ binding site [ion binding]; other site 411154006098 G-X-G motif; other site 411154006099 Tetratricopeptide repeat; Region: TPR_12; pfam13424 411154006100 Tetratricopeptide repeat; Region: TPR_12; pfam13424 411154006101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154006102 binding surface 411154006103 TPR motif; other site 411154006104 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 411154006105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154006106 dimer interface [polypeptide binding]; other site 411154006107 phosphorylation site [posttranslational modification] 411154006108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154006109 ATP binding site [chemical binding]; other site 411154006110 Mg2+ binding site [ion binding]; other site 411154006111 G-X-G motif; other site 411154006112 Response regulator receiver domain; Region: Response_reg; pfam00072 411154006113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154006114 active site 411154006115 phosphorylation site [posttranslational modification] 411154006116 intermolecular recognition site; other site 411154006117 dimerization interface [polypeptide binding]; other site 411154006118 Predicted membrane protein [Function unknown]; Region: COG4270 411154006119 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 411154006120 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 411154006121 active site 411154006122 Zn binding site [ion binding]; other site 411154006123 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 411154006124 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 411154006125 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 411154006126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 411154006127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 411154006128 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 411154006129 active site 411154006130 motif I; other site 411154006131 motif II; other site 411154006132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 411154006133 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 411154006134 Protein of unknown function (DUF819); Region: DUF819; cl02317 411154006135 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 411154006136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154006137 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 411154006138 putative substrate translocation pore; other site 411154006139 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 411154006140 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 411154006141 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 411154006142 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 411154006143 catalytic triad [active] 411154006144 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 411154006145 active site 411154006146 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 411154006147 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 411154006148 active site 411154006149 metal binding site [ion binding]; metal-binding site 411154006150 nudix motif; other site 411154006151 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 411154006152 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 411154006153 ligand binding site [chemical binding]; other site 411154006154 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 411154006155 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 411154006156 G1 box; other site 411154006157 putative GEF interaction site [polypeptide binding]; other site 411154006158 GTP/Mg2+ binding site [chemical binding]; other site 411154006159 Switch I region; other site 411154006160 G2 box; other site 411154006161 G3 box; other site 411154006162 Switch II region; other site 411154006163 G4 box; other site 411154006164 G5 box; other site 411154006165 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 411154006166 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 411154006167 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 411154006168 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 411154006169 DinB family; Region: DinB; cl17821 411154006170 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 411154006171 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 411154006172 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 411154006173 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 411154006174 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 411154006175 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 411154006176 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 411154006177 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 411154006178 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 411154006179 DNA binding site [nucleotide binding] 411154006180 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 411154006181 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 411154006182 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 411154006183 RNA polymerase beta subunit; Provisional; Region: rpoB; CHL00207 411154006184 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 411154006185 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 411154006186 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 411154006187 RPB12 interaction site [polypeptide binding]; other site 411154006188 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 411154006189 RPB3 interaction site [polypeptide binding]; other site 411154006190 RPB1 interaction site [polypeptide binding]; other site 411154006191 RPB11 interaction site [polypeptide binding]; other site 411154006192 RPB10 interaction site [polypeptide binding]; other site 411154006193 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 411154006194 core dimer interface [polypeptide binding]; other site 411154006195 peripheral dimer interface [polypeptide binding]; other site 411154006196 L10 interface [polypeptide binding]; other site 411154006197 L11 interface [polypeptide binding]; other site 411154006198 putative EF-Tu interaction site [polypeptide binding]; other site 411154006199 putative EF-G interaction site [polypeptide binding]; other site 411154006200 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 411154006201 23S rRNA interface [nucleotide binding]; other site 411154006202 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 411154006203 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 411154006204 mRNA/rRNA interface [nucleotide binding]; other site 411154006205 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 411154006206 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 411154006207 23S rRNA interface [nucleotide binding]; other site 411154006208 L7/L12 interface [polypeptide binding]; other site 411154006209 putative thiostrepton binding site; other site 411154006210 L25 interface [polypeptide binding]; other site 411154006211 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 411154006212 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 411154006213 putative homodimer interface [polypeptide binding]; other site 411154006214 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 411154006215 heterodimer interface [polypeptide binding]; other site 411154006216 homodimer interface [polypeptide binding]; other site 411154006217 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 411154006218 elongation factor Tu; Reviewed; Region: PRK12735 411154006219 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 411154006220 G1 box; other site 411154006221 GEF interaction site [polypeptide binding]; other site 411154006222 GTP/Mg2+ binding site [chemical binding]; other site 411154006223 Switch I region; other site 411154006224 G2 box; other site 411154006225 G3 box; other site 411154006226 Switch II region; other site 411154006227 G4 box; other site 411154006228 G5 box; other site 411154006229 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 411154006230 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 411154006231 Antibiotic Binding Site [chemical binding]; other site 411154006232 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 411154006233 30S subunit binding site; other site 411154006234 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 411154006235 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 411154006236 active site 411154006237 DNA binding site [nucleotide binding] 411154006238 Int/Topo IB signature motif; other site 411154006239 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 411154006240 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 411154006241 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 411154006242 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 411154006243 active site 411154006244 comEA protein; Region: comE; TIGR01259 411154006245 comEA protein; Region: comE; TIGR01259 411154006246 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 411154006247 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 411154006248 E3 interaction surface; other site 411154006249 lipoyl attachment site [posttranslational modification]; other site 411154006250 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 411154006251 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 411154006252 Ion channel; Region: Ion_trans_2; pfam07885 411154006253 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 411154006254 TrkA-N domain; Region: TrkA_N; pfam02254 411154006255 TrkA-C domain; Region: TrkA_C; pfam02080 411154006256 PspC domain; Region: PspC; cl00864 411154006257 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 411154006258 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 411154006259 active site 411154006260 catalytic triad [active] 411154006261 oxyanion hole [active] 411154006262 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 411154006263 lipoyl-biotinyl attachment site [posttranslational modification]; other site 411154006264 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 411154006265 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 411154006266 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 411154006267 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 411154006268 dimer interface [polypeptide binding]; other site 411154006269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154006270 catalytic residue [active] 411154006271 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 411154006272 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 411154006273 FtsX-like permease family; Region: FtsX; pfam02687 411154006274 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 411154006275 Flagellin N-methylase; Region: FliB; pfam03692 411154006276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154006277 S-adenosylmethionine binding site [chemical binding]; other site 411154006278 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 411154006279 RNA binding surface [nucleotide binding]; other site 411154006280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154006281 S-adenosylmethionine binding site [chemical binding]; other site 411154006282 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 411154006283 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 411154006284 active site 411154006285 shikimate kinase; Reviewed; Region: aroK; PRK00131 411154006286 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 411154006287 ADP binding site [chemical binding]; other site 411154006288 magnesium binding site [ion binding]; other site 411154006289 putative shikimate binding site; other site 411154006290 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 411154006291 non-specific DNA binding site [nucleotide binding]; other site 411154006292 salt bridge; other site 411154006293 sequence-specific DNA binding site [nucleotide binding]; other site 411154006294 Right handed beta helix region; Region: Beta_helix; pfam13229 411154006295 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 411154006296 Interdomain contacts; other site 411154006297 Cytokine receptor motif; other site 411154006298 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 411154006299 Interdomain contacts; other site 411154006300 Cytokine receptor motif; other site 411154006301 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 411154006302 Interdomain contacts; other site 411154006303 Cytokine receptor motif; other site 411154006304 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 411154006305 Interdomain contacts; other site 411154006306 Cytokine receptor motif; other site 411154006307 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 411154006308 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 411154006309 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 411154006310 NUMOD4 motif; Region: NUMOD4; pfam07463 411154006311 NUMOD4 motif; Region: NUMOD4; pfam07463 411154006312 HNH endonuclease; Region: HNH_3; pfam13392 411154006313 Transposase; Region: HTH_Tnp_1; cl17663 411154006314 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 411154006315 YopX protein; Region: YopX; pfam09643 411154006316 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 411154006317 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 411154006318 Terminase-like family; Region: Terminase_6; pfam03237 411154006319 Terminase small subunit; Region: Terminase_2; cl01513 411154006320 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 411154006321 active site 411154006322 Protein of unknown function (DUF551); Region: DUF551; pfam04448 411154006323 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 411154006324 DNA methylase; Region: N6_N4_Mtase; cl17433 411154006325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154006326 S-adenosylmethionine binding site [chemical binding]; other site 411154006327 Methyltransferase domain; Region: Methyltransf_27; pfam13708 411154006328 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 411154006329 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 411154006330 YopX protein; Region: YopX; pfam09643 411154006331 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 411154006332 RecT family; Region: RecT; pfam03837 411154006333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154006334 AAA domain; Region: AAA_23; pfam13476 411154006335 Walker A/P-loop; other site 411154006336 ATP binding site [chemical binding]; other site 411154006337 Helix-turn-helix domain; Region: HTH_17; cl17695 411154006338 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 411154006339 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 411154006340 DNA binding residues [nucleotide binding] 411154006341 dimerization interface [polypeptide binding]; other site 411154006342 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 411154006343 non-specific DNA binding site [nucleotide binding]; other site 411154006344 salt bridge; other site 411154006345 sequence-specific DNA binding site [nucleotide binding]; other site 411154006346 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 411154006347 Catalytic site [active] 411154006348 NUMOD4 motif; Region: NUMOD4; pfam07463 411154006349 HNH endonuclease; Region: HNH_3; pfam13392 411154006350 AP2 domain; Region: AP2; pfam00847 411154006351 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 411154006352 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 411154006353 active site 411154006354 catalytic residues [active] 411154006355 DNA binding site [nucleotide binding] 411154006356 Int/Topo IB signature motif; other site 411154006357 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 411154006358 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 411154006359 DNA binding residues [nucleotide binding] 411154006360 B12 binding domain; Region: B12-binding_2; pfam02607 411154006361 phytoene desaturase; Region: crtI_fam; TIGR02734 411154006362 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 411154006363 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 411154006364 active site lid residues [active] 411154006365 substrate binding pocket [chemical binding]; other site 411154006366 catalytic residues [active] 411154006367 substrate-Mg2+ binding site; other site 411154006368 aspartate-rich region 1; other site 411154006369 aspartate-rich region 2; other site 411154006370 beta-carotene hydroxylase; Region: PLN02601 411154006371 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 411154006372 lycopene cyclase; Region: lycopene_cycl; TIGR01789 411154006373 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 411154006374 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 411154006375 catalytic residues [active] 411154006376 aconitate hydratase; Validated; Region: PRK07229 411154006377 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 411154006378 substrate binding site [chemical binding]; other site 411154006379 ligand binding site [chemical binding]; other site 411154006380 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 411154006381 substrate binding site [chemical binding]; other site 411154006382 MoxR-like ATPases [General function prediction only]; Region: COG0714 411154006383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154006384 Walker A motif; other site 411154006385 ATP binding site [chemical binding]; other site 411154006386 Walker B motif; other site 411154006387 arginine finger; other site 411154006388 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 411154006389 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 411154006390 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 411154006391 hydrophobic ligand binding site; other site 411154006392 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 411154006393 periplasmic chaperone; Provisional; Region: PRK10780 411154006394 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 411154006395 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 411154006396 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 411154006397 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 411154006398 active site 411154006399 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154006400 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 411154006401 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154006402 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 411154006403 Imelysin; Region: Peptidase_M75; pfam09375 411154006404 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 411154006405 active site 411154006406 catalytic residues [active] 411154006407 metal binding site [ion binding]; metal-binding site 411154006408 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 411154006409 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 411154006410 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 411154006411 quinone interaction residues [chemical binding]; other site 411154006412 active site 411154006413 catalytic residues [active] 411154006414 FMN binding site [chemical binding]; other site 411154006415 substrate binding site [chemical binding]; other site 411154006416 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154006417 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 411154006418 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154006419 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154006420 peptidase T; Region: peptidase-T; TIGR01882 411154006421 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 411154006422 metal binding site [ion binding]; metal-binding site 411154006423 dimer interface [polypeptide binding]; other site 411154006424 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 411154006425 Preprotein translocase subunit; Region: YajC; pfam02699 411154006426 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 411154006427 transcription antitermination factor NusB; Region: nusB; TIGR01951 411154006428 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 411154006429 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 411154006430 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 411154006431 NAD binding site [chemical binding]; other site 411154006432 Phe binding site; other site 411154006433 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 411154006434 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 411154006435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154006436 Walker A/P-loop; other site 411154006437 ATP binding site [chemical binding]; other site 411154006438 Q-loop/lid; other site 411154006439 ABC transporter signature motif; other site 411154006440 Walker B; other site 411154006441 D-loop; other site 411154006442 H-loop/switch region; other site 411154006443 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 411154006444 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 411154006445 putative active site [active] 411154006446 Zn binding site [ion binding]; other site 411154006447 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 411154006448 conserved cys residue [active] 411154006449 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 411154006450 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 411154006451 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 411154006452 TrkA-N domain; Region: TrkA_N; pfam02254 411154006453 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 411154006454 dimer interface [polypeptide binding]; other site 411154006455 putative tRNA-binding site [nucleotide binding]; other site 411154006456 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 411154006457 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 411154006458 putative catalytic residue [active] 411154006459 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 411154006460 dimer interface [polypeptide binding]; other site 411154006461 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 411154006462 decamer (pentamer of dimers) interface [polypeptide binding]; other site 411154006463 catalytic triad [active] 411154006464 metal-dependent hydrolase; Provisional; Region: PRK13291 411154006465 DinB superfamily; Region: DinB_2; pfam12867 411154006466 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 411154006467 active site 411154006468 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 411154006469 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 411154006470 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 411154006471 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 411154006472 active site 411154006473 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 411154006474 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 411154006475 putative ligand binding pocket/active site [active] 411154006476 putative metal binding site [ion binding]; other site 411154006477 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 411154006478 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 411154006479 Amidohydrolase; Region: Amidohydro_4; pfam13147 411154006480 active site 411154006481 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154006482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154006483 binding surface 411154006484 TPR motif; other site 411154006485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154006486 TPR motif; other site 411154006487 binding surface 411154006488 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 411154006489 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 411154006490 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154006491 binding surface 411154006492 TPR motif; other site 411154006493 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 411154006494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154006495 binding surface 411154006496 TPR motif; other site 411154006497 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 411154006498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154006499 Walker A/P-loop; other site 411154006500 ATP binding site [chemical binding]; other site 411154006501 Q-loop/lid; other site 411154006502 ABC transporter signature motif; other site 411154006503 Walker B; other site 411154006504 D-loop; other site 411154006505 H-loop/switch region; other site 411154006506 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 411154006507 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 411154006508 nucleotide binding site [chemical binding]; other site 411154006509 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 411154006510 EamA-like transporter family; Region: EamA; pfam00892 411154006511 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 411154006512 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 411154006513 G1 box; other site 411154006514 putative GEF interaction site [polypeptide binding]; other site 411154006515 GTP/Mg2+ binding site [chemical binding]; other site 411154006516 Switch I region; other site 411154006517 G2 box; other site 411154006518 G3 box; other site 411154006519 Switch II region; other site 411154006520 G4 box; other site 411154006521 G5 box; other site 411154006522 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 411154006523 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 411154006524 DinB family; Region: DinB; cl17821 411154006525 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 411154006526 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 411154006527 BCCT family transporter; Region: BCCT; pfam02028 411154006528 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 411154006529 Ligand Binding Site [chemical binding]; other site 411154006530 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 411154006531 Ligand Binding Site [chemical binding]; other site 411154006532 Conserved TM helix; Region: TM_helix; pfam05552 411154006533 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 411154006534 putative catalytic site [active] 411154006535 putative metal binding site [ion binding]; other site 411154006536 putative phosphate binding site [ion binding]; other site 411154006537 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 411154006538 dimerization interface [polypeptide binding]; other site 411154006539 putative DNA binding site [nucleotide binding]; other site 411154006540 Transcriptional regulators [Transcription]; Region: MarR; COG1846 411154006541 putative Zn2+ binding site [ion binding]; other site 411154006542 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 411154006543 Inner membrane protein CreD; Region: CreD; pfam06123 411154006544 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 411154006545 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 411154006546 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 411154006547 PemK-like protein; Region: PemK; pfam02452 411154006548 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 411154006549 Conserved TM helix; Region: TM_helix; pfam05552 411154006550 Mechanosensitive ion channel; Region: MS_channel; pfam00924 411154006551 Saccharopine Dehydrogenase like proteins; Region: SDH_like; cd05199 411154006552 active site 411154006553 ligand binding site [chemical binding]; other site 411154006554 NAD(P) binding site [chemical binding]; other site 411154006555 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 411154006556 WYL domain; Region: WYL; pfam13280 411154006557 PIN domain; Region: PIN; pfam01850 411154006558 putative active site [active] 411154006559 WYL domain; Region: WYL; pfam13280 411154006560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154006561 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 411154006562 Walker A motif; other site 411154006563 ATP binding site [chemical binding]; other site 411154006564 Walker B motif; other site 411154006565 arginine finger; other site 411154006566 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 411154006567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154006568 S-adenosylmethionine binding site [chemical binding]; other site 411154006569 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 411154006570 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 411154006571 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 411154006572 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 411154006573 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 411154006574 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 411154006575 ATP binding site [chemical binding]; other site 411154006576 putative Mg++ binding site [ion binding]; other site 411154006577 Protein of unknown function DUF262; Region: DUF262; pfam03235 411154006578 Uncharacterized conserved protein [Function unknown]; Region: COG1479 411154006579 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 411154006580 Protein of unknown function DUF262; Region: DUF262; pfam03235 411154006581 Uncharacterized conserved protein [Function unknown]; Region: COG1479 411154006582 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 411154006583 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 411154006584 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 411154006585 HsdM N-terminal domain; Region: HsdM_N; pfam12161 411154006586 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 411154006587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 411154006588 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 411154006589 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 411154006590 Short C-terminal domain; Region: SHOCT; pfam09851 411154006591 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 411154006592 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 411154006593 HSP70 interaction site [polypeptide binding]; other site 411154006594 Protein of unknown function (DUF805); Region: DUF805; pfam05656 411154006595 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 411154006596 HSP70 interaction site [polypeptide binding]; other site 411154006597 Staphylococcal nuclease homologues; Region: SNc; smart00318 411154006598 Catalytic site; other site 411154006599 Staphylococcal nuclease homologue; Region: SNase; pfam00565 411154006600 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 411154006601 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 411154006602 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 411154006603 nucleotide binding site [chemical binding]; other site 411154006604 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 411154006605 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 411154006606 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 411154006607 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 411154006608 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 411154006609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 411154006610 active site 411154006611 phosphorylation site [posttranslational modification] 411154006612 intermolecular recognition site; other site 411154006613 dimerization interface [polypeptide binding]; other site 411154006614 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 411154006615 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 411154006616 Two component regulator propeller; Region: Reg_prop; pfam07494 411154006617 Histidine kinase; Region: His_kinase; pfam06580 411154006618 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 411154006619 ATP binding site [chemical binding]; other site 411154006620 Mg2+ binding site [ion binding]; other site 411154006621 G-X-G motif; other site 411154006622 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 411154006623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154006624 active site 411154006625 phosphorylation site [posttranslational modification] 411154006626 intermolecular recognition site; other site 411154006627 dimerization interface [polypeptide binding]; other site 411154006628 LytTr DNA-binding domain; Region: LytTR; smart00850 411154006629 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 411154006630 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 411154006631 substrate binding pocket [chemical binding]; other site 411154006632 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 411154006633 Tetratricopeptide repeat; Region: TPR_12; pfam13424 411154006634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154006635 binding surface 411154006636 TPR motif; other site 411154006637 Histidine kinase; Region: HisKA_3; pfam07730 411154006638 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 411154006639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154006640 ATP binding site [chemical binding]; other site 411154006641 Mg2+ binding site [ion binding]; other site 411154006642 G-X-G motif; other site 411154006643 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 411154006644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154006645 active site 411154006646 phosphorylation site [posttranslational modification] 411154006647 intermolecular recognition site; other site 411154006648 dimerization interface [polypeptide binding]; other site 411154006649 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 411154006650 DNA binding residues [nucleotide binding] 411154006651 dimerization interface [polypeptide binding]; other site 411154006652 ATPase involved in DNA repair; Region: DUF3686; pfam12458 411154006653 AAA domain; Region: AAA_22; pfam13401 411154006654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154006655 Walker A motif; other site 411154006656 ATP binding site [chemical binding]; other site 411154006657 Walker B motif; other site 411154006658 arginine finger; other site 411154006659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 411154006660 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 411154006661 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 411154006662 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 411154006663 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 411154006664 non-specific DNA binding site [nucleotide binding]; other site 411154006665 salt bridge; other site 411154006666 sequence-specific DNA binding site [nucleotide binding]; other site 411154006667 Tetratricopeptide repeat; Region: TPR_12; pfam13424 411154006668 Tetratricopeptide repeat; Region: TPR_12; pfam13424 411154006669 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154006670 binding surface 411154006671 TPR motif; other site 411154006672 Tetratricopeptide repeat; Region: TPR_12; pfam13424 411154006673 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154006674 binding surface 411154006675 TPR motif; other site 411154006676 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 411154006677 Histidine kinase; Region: HisKA_2; pfam07568 411154006678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154006679 ATP binding site [chemical binding]; other site 411154006680 Mg2+ binding site [ion binding]; other site 411154006681 G-X-G motif; other site 411154006682 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 411154006683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154006684 active site 411154006685 phosphorylation site [posttranslational modification] 411154006686 intermolecular recognition site; other site 411154006687 dimerization interface [polypeptide binding]; other site 411154006688 LytTr DNA-binding domain; Region: LytTR; smart00850 411154006689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 411154006690 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 411154006691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154006692 putative substrate translocation pore; other site 411154006693 Protein of unknown function (DUF808); Region: DUF808; cl01002 411154006694 Mechanosensitive ion channel; Region: MS_channel; pfam00924 411154006695 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 411154006696 hydroperoxidase II; Provisional; Region: katE; PRK11249 411154006697 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 411154006698 tetramer interface [polypeptide binding]; other site 411154006699 heme binding pocket [chemical binding]; other site 411154006700 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 411154006701 domain interactions; other site 411154006702 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154006703 von Willebrand factor; Region: vWF_A; pfam12450 411154006704 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 411154006705 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 411154006706 metal ion-dependent adhesion site (MIDAS); other site 411154006707 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 411154006708 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 411154006709 active site 411154006710 catalytic site [active] 411154006711 substrate binding site [chemical binding]; other site 411154006712 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 411154006713 GIY-YIG motif/motif A; other site 411154006714 active site 411154006715 catalytic site [active] 411154006716 putative DNA binding site [nucleotide binding]; other site 411154006717 metal binding site [ion binding]; metal-binding site 411154006718 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 411154006719 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 411154006720 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 411154006721 ATP binding site [chemical binding]; other site 411154006722 putative Mg++ binding site [ion binding]; other site 411154006723 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 411154006724 nucleotide binding region [chemical binding]; other site 411154006725 ATP-binding site [chemical binding]; other site 411154006726 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 411154006727 RNA binding site [nucleotide binding]; other site 411154006728 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 411154006729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154006730 S-adenosylmethionine binding site [chemical binding]; other site 411154006731 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 411154006732 DNA binding residues [nucleotide binding] 411154006733 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 411154006734 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 411154006735 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 411154006736 Zn2+ binding site [ion binding]; other site 411154006737 Mg2+ binding site [ion binding]; other site 411154006738 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 411154006739 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 411154006740 active site residue [active] 411154006741 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 411154006742 MarR family; Region: MarR; pfam01047 411154006743 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 411154006744 FMN binding site [chemical binding]; other site 411154006745 dimer interface [polypeptide binding]; other site 411154006746 YceI-like domain; Region: YceI; pfam04264 411154006747 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 411154006748 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 411154006749 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 411154006750 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 411154006751 Glutamine amidotransferase class-I; Region: GATase; pfam00117 411154006752 glutamine binding [chemical binding]; other site 411154006753 catalytic triad [active] 411154006754 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 411154006755 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 411154006756 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 411154006757 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 411154006758 active site 411154006759 ribulose/triose binding site [chemical binding]; other site 411154006760 phosphate binding site [ion binding]; other site 411154006761 substrate (anthranilate) binding pocket [chemical binding]; other site 411154006762 product (indole) binding pocket [chemical binding]; other site 411154006763 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 411154006764 active site 411154006765 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 411154006766 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 411154006767 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154006768 catalytic residue [active] 411154006769 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 411154006770 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 411154006771 substrate binding site [chemical binding]; other site 411154006772 active site 411154006773 catalytic residues [active] 411154006774 heterodimer interface [polypeptide binding]; other site 411154006775 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 411154006776 putative active site [active] 411154006777 pyruvate carboxylase; Reviewed; Region: PRK12999 411154006778 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 411154006779 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 411154006780 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 411154006781 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 411154006782 active site 411154006783 catalytic residues [active] 411154006784 metal binding site [ion binding]; metal-binding site 411154006785 homodimer binding site [polypeptide binding]; other site 411154006786 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 411154006787 carboxyltransferase (CT) interaction site; other site 411154006788 biotinylation site [posttranslational modification]; other site 411154006789 hypothetical protein; Validated; Region: PRK02101 411154006790 RES domain; Region: RES; pfam08808 411154006791 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 411154006792 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 411154006793 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 411154006794 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 411154006795 RNA binding surface [nucleotide binding]; other site 411154006796 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 411154006797 active site 411154006798 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 411154006799 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 411154006800 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 411154006801 ATP-grasp domain; Region: ATP-grasp_4; cl17255 411154006802 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 411154006803 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 411154006804 active site 411154006805 (T/H)XGH motif; other site 411154006806 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154006807 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 411154006808 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154006809 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 411154006810 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 411154006811 putative active site [active] 411154006812 Zn binding site [ion binding]; other site 411154006813 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 411154006814 active site 411154006815 Ap6A binding site [chemical binding]; other site 411154006816 nudix motif; other site 411154006817 metal binding site [ion binding]; metal-binding site 411154006818 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 411154006819 active site 411154006820 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 411154006821 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 411154006822 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 411154006823 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 411154006824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154006825 Walker A motif; other site 411154006826 ATP binding site [chemical binding]; other site 411154006827 Walker B motif; other site 411154006828 arginine finger; other site 411154006829 Peptidase family M41; Region: Peptidase_M41; pfam01434 411154006830 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 411154006831 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 411154006832 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 411154006833 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 411154006834 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 411154006835 acyl-CoA binding pocket [chemical binding]; other site 411154006836 CoA binding site [chemical binding]; other site 411154006837 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 411154006838 Fasciclin domain; Region: Fasciclin; pfam02469 411154006839 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 411154006840 active site 411154006841 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 411154006842 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 411154006843 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 411154006844 lipoyl synthase; Provisional; Region: PRK05481 411154006845 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 411154006846 FeS/SAM binding site; other site 411154006847 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 411154006848 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 411154006849 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 411154006850 Tetratricopeptide repeat; Region: TPR_12; pfam13424 411154006851 Tetratricopeptide repeat; Region: TPR_12; pfam13424 411154006852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154006853 dimer interface [polypeptide binding]; other site 411154006854 phosphorylation site [posttranslational modification] 411154006855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154006856 ATP binding site [chemical binding]; other site 411154006857 Mg2+ binding site [ion binding]; other site 411154006858 G-X-G motif; other site 411154006859 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 411154006860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154006861 active site 411154006862 phosphorylation site [posttranslational modification] 411154006863 intermolecular recognition site; other site 411154006864 dimerization interface [polypeptide binding]; other site 411154006865 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 411154006866 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 411154006867 Uncharacterized conserved protein [Function unknown]; Region: COG0327 411154006868 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 411154006869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 411154006870 Uncharacterized conserved protein [Function unknown]; Region: COG0327 411154006871 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 411154006872 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 411154006873 Putative zinc ribbon domain; Region: DUF164; pfam02591 411154006874 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 411154006875 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 411154006876 FAD binding domain; Region: FAD_binding_3; pfam01494 411154006877 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 411154006878 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 411154006879 FMN binding site [chemical binding]; other site 411154006880 active site 411154006881 substrate binding site [chemical binding]; other site 411154006882 catalytic residue [active] 411154006883 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 411154006884 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 411154006885 DNA photolyase; Region: DNA_photolyase; pfam00875 411154006886 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 411154006887 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 411154006888 tropinone reductase; Provisional; Region: PRK09242 411154006889 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 411154006890 NAD(P) binding site [chemical binding]; other site 411154006891 active site 411154006892 kynureninase; Region: kynureninase; TIGR01814 411154006893 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 411154006894 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 411154006895 catalytic residue [active] 411154006896 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 411154006897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154006898 S-adenosylmethionine binding site [chemical binding]; other site 411154006899 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 411154006900 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 411154006901 active site 411154006902 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 411154006903 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 411154006904 Zn binding site [ion binding]; other site 411154006905 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154006906 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154006907 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154006908 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 411154006909 active site pocket [active] 411154006910 oxyanion hole [active] 411154006911 catalytic triad [active] 411154006912 active site nucleophile [active] 411154006913 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 411154006914 glutaminase; Provisional; Region: PRK00971 411154006915 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 411154006916 prolyl-tRNA synthetase; Provisional; Region: PRK08661 411154006917 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 411154006918 dimer interface [polypeptide binding]; other site 411154006919 motif 1; other site 411154006920 active site 411154006921 motif 2; other site 411154006922 motif 3; other site 411154006923 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 411154006924 anticodon binding site; other site 411154006925 zinc-binding site [ion binding]; other site 411154006926 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 411154006927 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 411154006928 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 411154006929 GTP cyclohydrolase I; Provisional; Region: PLN03044 411154006930 active site 411154006931 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 411154006932 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 411154006933 active site 411154006934 HIGH motif; other site 411154006935 nucleotide binding site [chemical binding]; other site 411154006936 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 411154006937 KMSKS motif; other site 411154006938 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 411154006939 tRNA binding surface [nucleotide binding]; other site 411154006940 anticodon binding site; other site 411154006941 Haemolytic domain; Region: Haemolytic; pfam01809 411154006942 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 411154006943 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 411154006944 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 411154006945 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 411154006946 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 411154006947 Protein export membrane protein; Region: SecD_SecF; pfam02355 411154006948 malate dehydrogenase; Reviewed; Region: PRK06223 411154006949 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 411154006950 NAD(P) binding site [chemical binding]; other site 411154006951 dimer interface [polypeptide binding]; other site 411154006952 tetramer (dimer of dimers) interface [polypeptide binding]; other site 411154006953 substrate binding site [chemical binding]; other site 411154006954 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 411154006955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154006956 ATP binding site [chemical binding]; other site 411154006957 Mg2+ binding site [ion binding]; other site 411154006958 G-X-G motif; other site 411154006959 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 411154006960 anchoring element; other site 411154006961 dimer interface [polypeptide binding]; other site 411154006962 ATP binding site [chemical binding]; other site 411154006963 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 411154006964 active site 411154006965 putative metal-binding site [ion binding]; other site 411154006966 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 411154006967 asparagine synthetase B; Provisional; Region: asnB; PRK09431 411154006968 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 411154006969 active site 411154006970 dimer interface [polypeptide binding]; other site 411154006971 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 411154006972 Ligand Binding Site [chemical binding]; other site 411154006973 Molecular Tunnel; other site 411154006974 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 411154006975 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 411154006976 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 411154006977 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 411154006978 putative active site [active] 411154006979 Zn binding site [ion binding]; other site 411154006980 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 411154006981 amidase catalytic site [active] 411154006982 Zn binding residues [ion binding]; other site 411154006983 substrate binding site [chemical binding]; other site 411154006984 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 411154006985 starch binding outer membrane protein SusD; Region: SusD; cd08977 411154006986 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154006987 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 411154006988 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154006989 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 411154006990 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 411154006991 dimer interface [polypeptide binding]; other site 411154006992 catalytic triad [active] 411154006993 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 411154006994 Domain of unknown function DUF87; Region: DUF87; pfam01935 411154006995 Zonular occludens toxin (Zot); Region: Zot; cl17485 411154006996 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719 411154006997 dimer interface [polypeptide binding]; other site 411154006998 substrate binding site [chemical binding]; other site 411154006999 metal binding sites [ion binding]; metal-binding site 411154007000 cell division protein FtsZ; Validated; Region: PRK09330 411154007001 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 411154007002 nucleotide binding site [chemical binding]; other site 411154007003 SulA interaction site; other site 411154007004 cell division protein FtsA; Region: ftsA; TIGR01174 411154007005 Cell division protein FtsA; Region: FtsA; smart00842 411154007006 Cell division protein FtsA; Region: FtsA; pfam14450 411154007007 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 411154007008 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 411154007009 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 411154007010 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 411154007011 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 411154007012 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 411154007013 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 411154007014 active site 411154007015 homodimer interface [polypeptide binding]; other site 411154007016 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 411154007017 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 411154007018 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 411154007019 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 411154007020 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 411154007021 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 411154007022 Mg++ binding site [ion binding]; other site 411154007023 putative catalytic motif [active] 411154007024 putative substrate binding site [chemical binding]; other site 411154007025 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 411154007026 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 411154007027 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 411154007028 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 411154007029 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 411154007030 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 411154007031 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 411154007032 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 411154007033 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 411154007034 MraW methylase family; Region: Methyltransf_5; cl17771 411154007035 cell division protein MraZ; Reviewed; Region: PRK00326 411154007036 MraZ protein; Region: MraZ; pfam02381 411154007037 MraZ protein; Region: MraZ; pfam02381 411154007038 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 411154007039 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 411154007040 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 411154007041 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 411154007042 G1 box; other site 411154007043 GTP/Mg2+ binding site [chemical binding]; other site 411154007044 Switch I region; other site 411154007045 G2 box; other site 411154007046 G3 box; other site 411154007047 Switch II region; other site 411154007048 G4 box; other site 411154007049 G5 box; other site 411154007050 gliding motility-associated protein GldC; Region: GldC; TIGR03515 411154007051 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 411154007052 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 411154007053 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 411154007054 homodimer interface [polypeptide binding]; other site 411154007055 NAD binding pocket [chemical binding]; other site 411154007056 ATP binding pocket [chemical binding]; other site 411154007057 Mg binding site [ion binding]; other site 411154007058 active-site loop [active] 411154007059 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 411154007060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154007061 active site 411154007062 phosphorylation site [posttranslational modification] 411154007063 intermolecular recognition site; other site 411154007064 dimerization interface [polypeptide binding]; other site 411154007065 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 411154007066 DNA binding residues [nucleotide binding] 411154007067 dimerization interface [polypeptide binding]; other site 411154007068 DNA primase; Validated; Region: dnaG; PRK05667 411154007069 CHC2 zinc finger; Region: zf-CHC2; cl17510 411154007070 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 411154007071 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 411154007072 active site 411154007073 metal binding site [ion binding]; metal-binding site 411154007074 interdomain interaction site; other site 411154007075 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 411154007076 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 411154007077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 411154007078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 411154007079 DNA binding residues [nucleotide binding] 411154007080 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 411154007081 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 411154007082 RNA binding surface [nucleotide binding]; other site 411154007083 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 411154007084 probable active site [active] 411154007085 hydroxylamine reductase; Provisional; Region: PRK12310 411154007086 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 411154007087 Domain of unknown function DUF20; Region: UPF0118; pfam01594 411154007088 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 411154007089 Uncharacterized conserved protein [Function unknown]; Region: COG3339 411154007090 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 411154007091 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 411154007092 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 411154007093 homodimer interface [polypeptide binding]; other site 411154007094 NADP binding site [chemical binding]; other site 411154007095 substrate binding site [chemical binding]; other site 411154007096 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 411154007097 four helix bundle protein; Region: TIGR02436 411154007098 signal recognition particle protein; Provisional; Region: PRK10867 411154007099 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 411154007100 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 411154007101 P loop; other site 411154007102 GTP binding site [chemical binding]; other site 411154007103 Signal peptide binding domain; Region: SRP_SPB; pfam02978 411154007104 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 411154007105 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 411154007106 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 411154007107 active site 411154007108 HIGH motif; other site 411154007109 nucleotide binding site [chemical binding]; other site 411154007110 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 411154007111 KMSK motif region; other site 411154007112 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 411154007113 tRNA binding surface [nucleotide binding]; other site 411154007114 anticodon binding site; other site 411154007115 MarC family integral membrane protein; Region: MarC; cl00919 411154007116 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 411154007117 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 411154007118 putative NAD(P) binding site [chemical binding]; other site 411154007119 putative active site [active] 411154007120 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 411154007121 BCCT family transporter; Region: BCCT; pfam02028 411154007122 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 411154007123 Amidinotransferase; Region: Amidinotransf; pfam02274 411154007124 Amidinotransferase; Region: Amidinotransf; cl12043 411154007125 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 411154007126 dimer interface [polypeptide binding]; other site 411154007127 Citrate synthase; Region: Citrate_synt; pfam00285 411154007128 active site 411154007129 citrylCoA binding site [chemical binding]; other site 411154007130 NADH binding [chemical binding]; other site 411154007131 cationic pore residues; other site 411154007132 oxalacetate/citrate binding site [chemical binding]; other site 411154007133 coenzyme A binding site [chemical binding]; other site 411154007134 catalytic triad [active] 411154007135 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 411154007136 glycogen synthase; Provisional; Region: glgA; PRK00654 411154007137 ADP-binding pocket [chemical binding]; other site 411154007138 homodimer interface [polypeptide binding]; other site 411154007139 enolase; Provisional; Region: eno; PRK00077 411154007140 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 411154007141 dimer interface [polypeptide binding]; other site 411154007142 metal binding site [ion binding]; metal-binding site 411154007143 substrate binding pocket [chemical binding]; other site 411154007144 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 411154007145 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 411154007146 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 411154007147 catalytic site [active] 411154007148 subunit interface [polypeptide binding]; other site 411154007149 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 411154007150 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 411154007151 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 411154007152 alphaNTD homodimer interface [polypeptide binding]; other site 411154007153 alphaNTD - beta interaction site [polypeptide binding]; other site 411154007154 alphaNTD - beta' interaction site [polypeptide binding]; other site 411154007155 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 411154007156 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 411154007157 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 411154007158 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 411154007159 RNA binding surface [nucleotide binding]; other site 411154007160 30S ribosomal protein S11; Validated; Region: PRK05309 411154007161 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 411154007162 30S ribosomal protein S13; Region: bact_S13; TIGR03631 411154007163 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 411154007164 rRNA binding site [nucleotide binding]; other site 411154007165 predicted 30S ribosome binding site; other site 411154007166 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 411154007167 SecY translocase; Region: SecY; pfam00344 411154007168 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 411154007169 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 411154007170 23S rRNA binding site [nucleotide binding]; other site 411154007171 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 411154007172 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 411154007173 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 411154007174 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 411154007175 5S rRNA interface [nucleotide binding]; other site 411154007176 23S rRNA interface [nucleotide binding]; other site 411154007177 L5 interface [polypeptide binding]; other site 411154007178 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 411154007179 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 411154007180 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 411154007181 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 411154007182 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 411154007183 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 411154007184 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 411154007185 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 411154007186 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 411154007187 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 411154007188 RNA binding site [nucleotide binding]; other site 411154007189 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 411154007190 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 411154007191 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 411154007192 23S rRNA interface [nucleotide binding]; other site 411154007193 putative translocon interaction site; other site 411154007194 signal recognition particle (SRP54) interaction site; other site 411154007195 L23 interface [polypeptide binding]; other site 411154007196 trigger factor interaction site; other site 411154007197 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 411154007198 23S rRNA interface [nucleotide binding]; other site 411154007199 5S rRNA interface [nucleotide binding]; other site 411154007200 putative antibiotic binding site [chemical binding]; other site 411154007201 L25 interface [polypeptide binding]; other site 411154007202 L27 interface [polypeptide binding]; other site 411154007203 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 411154007204 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 411154007205 G-X-X-G motif; other site 411154007206 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 411154007207 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 411154007208 putative translocon binding site; other site 411154007209 protein-rRNA interface [nucleotide binding]; other site 411154007210 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 411154007211 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 411154007212 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 411154007213 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 411154007214 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 411154007215 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 411154007216 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 411154007217 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 411154007218 elongation factor G; Reviewed; Region: PRK12739 411154007219 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 411154007220 G1 box; other site 411154007221 putative GEF interaction site [polypeptide binding]; other site 411154007222 GTP/Mg2+ binding site [chemical binding]; other site 411154007223 Switch I region; other site 411154007224 G2 box; other site 411154007225 G3 box; other site 411154007226 Switch II region; other site 411154007227 G4 box; other site 411154007228 G5 box; other site 411154007229 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 411154007230 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 411154007231 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 411154007232 30S ribosomal protein S7; Validated; Region: PRK05302 411154007233 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 411154007234 S17 interaction site [polypeptide binding]; other site 411154007235 S8 interaction site; other site 411154007236 16S rRNA interaction site [nucleotide binding]; other site 411154007237 streptomycin interaction site [chemical binding]; other site 411154007238 23S rRNA interaction site [nucleotide binding]; other site 411154007239 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 411154007240 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 411154007241 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154007242 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 411154007243 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154007244 starch binding outer membrane protein SusD; Region: SusD; cl17845 411154007245 SusD family; Region: SusD; pfam07980 411154007246 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154007247 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 411154007248 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154007249 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 411154007250 starch binding outer membrane protein SusD; Region: SusD; cd08977 411154007251 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 411154007252 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154007253 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 411154007254 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154007255 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 411154007256 starch binding outer membrane protein SusD; Region: SusD; cd08977 411154007257 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 411154007258 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 411154007259 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 411154007260 Rhomboid family; Region: Rhomboid; cl11446 411154007261 recombination factor protein RarA; Reviewed; Region: PRK13342 411154007262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154007263 Walker A motif; other site 411154007264 ATP binding site [chemical binding]; other site 411154007265 Walker B motif; other site 411154007266 arginine finger; other site 411154007267 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 411154007268 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 411154007269 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 411154007270 motif II; other site 411154007271 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 411154007272 putative active site [active] 411154007273 hypothetical protein; Reviewed; Region: PRK00024 411154007274 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 411154007275 MPN+ (JAMM) motif; other site 411154007276 Zinc-binding site [ion binding]; other site 411154007277 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 411154007278 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 411154007279 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 411154007280 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 411154007281 TPR repeat; Region: TPR_11; pfam13414 411154007282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 411154007283 binding surface 411154007284 TPR motif; other site 411154007285 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 411154007286 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 411154007287 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 411154007288 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 411154007289 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 411154007290 ligand binding site [chemical binding]; other site 411154007291 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 411154007292 GTPase CgtA; Reviewed; Region: obgE; PRK12299 411154007293 GTP1/OBG; Region: GTP1_OBG; pfam01018 411154007294 Obg GTPase; Region: Obg; cd01898 411154007295 G1 box; other site 411154007296 GTP/Mg2+ binding site [chemical binding]; other site 411154007297 Switch I region; other site 411154007298 G2 box; other site 411154007299 G3 box; other site 411154007300 Switch II region; other site 411154007301 G4 box; other site 411154007302 G5 box; other site 411154007303 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 411154007304 active site 411154007305 adenylate kinase; Reviewed; Region: adk; PRK00279 411154007306 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 411154007307 AMP-binding site [chemical binding]; other site 411154007308 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 411154007309 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 411154007310 ATP-grasp domain; Region: ATP-grasp; pfam02222 411154007311 AIR carboxylase; Region: AIRC; pfam00731 411154007312 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 411154007313 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 411154007314 active site 411154007315 Zn binding site [ion binding]; other site 411154007316 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 411154007317 RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1 411154007318 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 411154007319 DNA binding residues [nucleotide binding] 411154007320 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 411154007321 glycine dehydrogenase; Provisional; Region: PRK05367 411154007322 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 411154007323 tetramer interface [polypeptide binding]; other site 411154007324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154007325 catalytic residue [active] 411154007326 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 411154007327 tetramer interface [polypeptide binding]; other site 411154007328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154007329 catalytic residue [active] 411154007330 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 411154007331 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 411154007332 dimer interface [polypeptide binding]; other site 411154007333 active site 411154007334 CoA binding pocket [chemical binding]; other site 411154007335 Methyltransferase domain; Region: Methyltransf_23; pfam13489 411154007336 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 411154007337 Family description; Region: VCBS; pfam13517 411154007338 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 411154007339 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 411154007340 FG-GAP repeat; Region: FG-GAP_2; pfam14312 411154007341 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 411154007342 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 411154007343 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 411154007344 DXD motif; other site 411154007345 Sulfatase; Region: Sulfatase; cl17466 411154007346 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 411154007347 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 411154007348 Permease; Region: Permease; pfam02405 411154007349 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 411154007350 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 411154007351 Walker A/P-loop; other site 411154007352 ATP binding site [chemical binding]; other site 411154007353 Q-loop/lid; other site 411154007354 ABC transporter signature motif; other site 411154007355 Walker B; other site 411154007356 D-loop; other site 411154007357 H-loop/switch region; other site 411154007358 Major Facilitator Superfamily; Region: MFS_1; pfam07690 411154007359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154007360 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 411154007361 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 411154007362 Substrate binding site; other site 411154007363 SprT homologues; Region: SprT; cl01182 411154007364 short chain dehydrogenase; Provisional; Region: PRK12828 411154007365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 411154007366 NAD(P) binding site [chemical binding]; other site 411154007367 active site 411154007368 M28 Zn-Peptidase IAP aminopeptidase may contain PA domain insert; Region: M28_like_5; cd08021 411154007369 Peptidase family M28; Region: Peptidase_M28; pfam04389 411154007370 metal binding site [ion binding]; metal-binding site 411154007371 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 411154007372 E3 interaction surface; other site 411154007373 lipoyl attachment site [posttranslational modification]; other site 411154007374 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 411154007375 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 411154007376 E3 interaction surface; other site 411154007377 lipoyl attachment site [posttranslational modification]; other site 411154007378 e3 binding domain; Region: E3_binding; pfam02817 411154007379 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 411154007380 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 411154007381 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 411154007382 tetramer interface [polypeptide binding]; other site 411154007383 TPP-binding site [chemical binding]; other site 411154007384 heterodimer interface [polypeptide binding]; other site 411154007385 phosphorylation loop region [posttranslational modification] 411154007386 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 411154007387 active site 411154007388 catalytic motif [active] 411154007389 Zn binding site [ion binding]; other site 411154007390 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 411154007391 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 411154007392 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 411154007393 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 411154007394 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 411154007395 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 411154007396 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 411154007397 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 411154007398 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 411154007399 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 411154007400 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 411154007401 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 411154007402 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 411154007403 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 411154007404 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 411154007405 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 411154007406 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 411154007407 FAD binding site [chemical binding]; other site 411154007408 homotetramer interface [polypeptide binding]; other site 411154007409 substrate binding pocket [chemical binding]; other site 411154007410 catalytic base [active] 411154007411 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 411154007412 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 411154007413 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 411154007414 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 411154007415 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 411154007416 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 411154007417 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 411154007418 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 411154007419 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 411154007420 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 411154007421 active site 411154007422 dimer interface [polypeptide binding]; other site 411154007423 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 411154007424 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 411154007425 active site 411154007426 FMN binding site [chemical binding]; other site 411154007427 substrate binding site [chemical binding]; other site 411154007428 3Fe-4S cluster binding site [ion binding]; other site 411154007429 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 411154007430 domain interface; other site 411154007431 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 411154007432 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 411154007433 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 411154007434 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 411154007435 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 411154007436 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 411154007437 starch binding outer membrane protein SusD; Region: SusD; cd08977 411154007438 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 411154007439 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154007440 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 411154007441 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154007442 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 411154007443 RNA/DNA hybrid binding site [nucleotide binding]; other site 411154007444 active site 411154007445 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 411154007446 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 411154007447 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 411154007448 dimer interface [polypeptide binding]; other site 411154007449 putative anticodon binding site; other site 411154007450 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 411154007451 motif 1; other site 411154007452 active site 411154007453 motif 2; other site 411154007454 motif 3; other site 411154007455 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 411154007456 active site 411154007457 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 411154007458 FAD binding domain; Region: FAD_binding_4; pfam01565 411154007459 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 411154007460 aspartate aminotransferase; Provisional; Region: PRK07568 411154007461 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 411154007462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154007463 homodimer interface [polypeptide binding]; other site 411154007464 catalytic residue [active] 411154007465 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 411154007466 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 411154007467 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 411154007468 active site 411154007469 HIGH motif; other site 411154007470 nucleotide binding site [chemical binding]; other site 411154007471 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 411154007472 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 411154007473 active site 411154007474 KMSKS motif; other site 411154007475 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 411154007476 tRNA binding surface [nucleotide binding]; other site 411154007477 anticodon binding site; other site 411154007478 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 411154007479 Predicted permease; Region: DUF318; cl17795 411154007480 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 411154007481 metal-binding site [ion binding] 411154007482 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 411154007483 metal-binding site [ion binding] 411154007484 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 411154007485 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 411154007486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 411154007487 motif II; other site 411154007488 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 411154007489 dimerization interface [polypeptide binding]; other site 411154007490 Ion channel; Region: Ion_trans_2; pfam07885 411154007491 Helix-turn-helix domain; Region: HTH_18; pfam12833 411154007492 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 411154007493 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 411154007494 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 411154007495 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 411154007496 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 411154007497 Multicopper oxidase; Region: Cu-oxidase; pfam00394 411154007498 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 411154007499 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 411154007500 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 411154007501 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 411154007502 Domain of unknown function (DUF305); Region: DUF305; cl17794 411154007503 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 411154007504 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 411154007505 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 411154007506 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 411154007507 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 411154007508 HlyD family secretion protein; Region: HlyD_3; pfam13437 411154007509 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 411154007510 Outer membrane efflux protein; Region: OEP; pfam02321 411154007511 Outer membrane efflux protein; Region: OEP; pfam02321 411154007512 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 411154007513 CCC1-related family of proteins; Region: CCC1_like; cd01059 411154007514 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 411154007515 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 411154007516 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 411154007517 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 411154007518 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 411154007519 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 411154007520 FtsX-like permease family; Region: FtsX; pfam02687 411154007521 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 411154007522 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 411154007523 purine monophosphate binding site [chemical binding]; other site 411154007524 dimer interface [polypeptide binding]; other site 411154007525 putative catalytic residues [active] 411154007526 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 411154007527 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 411154007528 rod shape-determining protein MreB; Provisional; Region: PRK13927 411154007529 MreB and similar proteins; Region: MreB_like; cd10225 411154007530 nucleotide binding site [chemical binding]; other site 411154007531 Mg binding site [ion binding]; other site 411154007532 putative protofilament interaction site [polypeptide binding]; other site 411154007533 RodZ interaction site [polypeptide binding]; other site 411154007534 rod shape-determining protein MreC; Provisional; Region: PRK13922 411154007535 rod shape-determining protein MreC; Region: MreC; pfam04085 411154007536 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 411154007537 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 411154007538 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 411154007539 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 411154007540 C-terminal peptidase (prc); Region: prc; TIGR00225 411154007541 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 411154007542 protein binding site [polypeptide binding]; other site 411154007543 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 411154007544 Catalytic dyad [active] 411154007545 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 411154007546 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 411154007547 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 411154007548 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 411154007549 NlpC/P60 family; Region: NLPC_P60; pfam00877 411154007550 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 411154007551 Competence protein; Region: Competence; pfam03772 411154007552 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 411154007553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154007554 putative substrate translocation pore; other site 411154007555 POT family; Region: PTR2; cl17359 411154007556 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 411154007557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154007558 putative substrate translocation pore; other site 411154007559 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 411154007560 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 411154007561 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 411154007562 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 411154007563 homodimer interface [polypeptide binding]; other site 411154007564 catalytic residues [active] 411154007565 NAD binding site [chemical binding]; other site 411154007566 substrate binding pocket [chemical binding]; other site 411154007567 flexible flap; other site 411154007568 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 411154007569 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 411154007570 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 411154007571 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 411154007572 Domain of unknown function DUF21; Region: DUF21; pfam01595 411154007573 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 411154007574 Transporter associated domain; Region: CorC_HlyC; smart01091 411154007575 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 411154007576 Tetratricopeptide repeat; Region: TPR_12; pfam13424 411154007577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154007578 binding surface 411154007579 TPR motif; other site 411154007580 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 411154007581 pantothenate kinase; Reviewed; Region: PRK13320 411154007582 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 411154007583 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 411154007584 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154007585 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154007586 GTP-binding protein Der; Reviewed; Region: PRK00093 411154007587 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 411154007588 G1 box; other site 411154007589 GTP/Mg2+ binding site [chemical binding]; other site 411154007590 Switch I region; other site 411154007591 G2 box; other site 411154007592 Switch II region; other site 411154007593 G3 box; other site 411154007594 G4 box; other site 411154007595 G5 box; other site 411154007596 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 411154007597 G1 box; other site 411154007598 GTP/Mg2+ binding site [chemical binding]; other site 411154007599 Switch I region; other site 411154007600 G2 box; other site 411154007601 G3 box; other site 411154007602 Switch II region; other site 411154007603 G4 box; other site 411154007604 G5 box; other site 411154007605 GTPase Era; Reviewed; Region: era; PRK00089 411154007606 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 411154007607 G1 box; other site 411154007608 GTP/Mg2+ binding site [chemical binding]; other site 411154007609 Switch I region; other site 411154007610 G2 box; other site 411154007611 Switch II region; other site 411154007612 G3 box; other site 411154007613 G4 box; other site 411154007614 G5 box; other site 411154007615 KH domain; Region: KH_2; pfam07650 411154007616 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 411154007617 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 411154007618 Sulfate transporter family; Region: Sulfate_transp; pfam00916 411154007619 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 411154007620 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154007621 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 411154007622 glycogen branching enzyme; Provisional; Region: PRK12313 411154007623 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 411154007624 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 411154007625 active site 411154007626 catalytic site [active] 411154007627 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 411154007628 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 411154007629 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 411154007630 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 411154007631 trimer interface [polypeptide binding]; other site 411154007632 active site 411154007633 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 411154007634 catalytic site [active] 411154007635 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 411154007636 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 411154007637 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 411154007638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154007639 ATP binding site [chemical binding]; other site 411154007640 Mg2+ binding site [ion binding]; other site 411154007641 G-X-G motif; other site 411154007642 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 411154007643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154007644 active site 411154007645 phosphorylation site [posttranslational modification] 411154007646 intermolecular recognition site; other site 411154007647 dimerization interface [polypeptide binding]; other site 411154007648 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 411154007649 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 411154007650 intersubunit interface [polypeptide binding]; other site 411154007651 active site 411154007652 catalytic residue [active] 411154007653 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 411154007654 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 411154007655 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 411154007656 active site 411154007657 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 411154007658 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 411154007659 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 411154007660 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 411154007661 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 411154007662 HlyD family secretion protein; Region: HlyD_3; pfam13437 411154007663 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 411154007664 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 411154007665 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 411154007666 ABC transporter; Region: ABC_tran_2; pfam12848 411154007667 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 411154007668 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 411154007669 gliding motility associated protien GldN; Region: GldN; TIGR03523 411154007670 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 411154007671 GldM N-terminal domain; Region: GldM_N; pfam12081 411154007672 GldM C-terminal domain; Region: GldM_C; pfam12080 411154007673 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 411154007674 gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525 411154007675 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 411154007676 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 411154007677 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 411154007678 putative active site [active] 411154007679 putative metal binding site [ion binding]; other site 411154007680 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 411154007681 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 411154007682 active site 411154007683 interdomain interaction site; other site 411154007684 putative metal-binding site [ion binding]; other site 411154007685 nucleotide binding site [chemical binding]; other site 411154007686 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 411154007687 domain I; other site 411154007688 DNA binding groove [nucleotide binding] 411154007689 phosphate binding site [ion binding]; other site 411154007690 domain II; other site 411154007691 domain III; other site 411154007692 nucleotide binding site [chemical binding]; other site 411154007693 catalytic site [active] 411154007694 domain IV; other site 411154007695 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 411154007696 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 411154007697 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 411154007698 classical (c) SDRs; Region: SDR_c; cd05233 411154007699 NAD(P) binding site [chemical binding]; other site 411154007700 active site 411154007701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154007702 putative substrate translocation pore; other site 411154007703 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 411154007704 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 411154007705 Protein of unknown function DUF58; Region: DUF58; pfam01882 411154007706 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 411154007707 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 411154007708 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 411154007709 catalytic residues [active] 411154007710 DJ-1 family protein; Region: not_thiJ; TIGR01383 411154007711 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 411154007712 conserved cys residue [active] 411154007713 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 411154007714 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 411154007715 active site 411154007716 catalytic site [active] 411154007717 substrate binding site [chemical binding]; other site 411154007718 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 411154007719 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 411154007720 active site 411154007721 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 411154007722 generic binding surface II; other site 411154007723 generic binding surface I; other site 411154007724 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 411154007725 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 411154007726 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 411154007727 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 411154007728 RimM N-terminal domain; Region: RimM; pfam01782 411154007729 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 411154007730 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 411154007731 active site 411154007732 HIGH motif; other site 411154007733 nucleotide binding site [chemical binding]; other site 411154007734 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 411154007735 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 411154007736 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 411154007737 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 411154007738 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 411154007739 active site 411154007740 KMSKS motif; other site 411154007741 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 411154007742 tRNA binding surface [nucleotide binding]; other site 411154007743 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 411154007744 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 411154007745 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 411154007746 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 411154007747 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 411154007748 Bacitracin resistance protein BacA; Region: BacA; pfam02673 411154007749 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 411154007750 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 411154007751 RNA binding site [nucleotide binding]; other site 411154007752 active site 411154007753 Gram-negative bacterial tonB protein; Region: TonB; cl10048 411154007754 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 411154007755 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 411154007756 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 411154007757 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 411154007758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 411154007759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154007760 phosphorylation site [posttranslational modification] 411154007761 dimer interface [polypeptide binding]; other site 411154007762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154007763 ATP binding site [chemical binding]; other site 411154007764 Mg2+ binding site [ion binding]; other site 411154007765 G-X-G motif; other site 411154007766 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 411154007767 active site 411154007768 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 411154007769 nucleotide binding site/active site [active] 411154007770 HIT family signature motif; other site 411154007771 catalytic residue [active] 411154007772 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 411154007773 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 411154007774 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 411154007775 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 411154007776 iron-sulfur cluster [ion binding]; other site 411154007777 [2Fe-2S] cluster binding site [ion binding]; other site 411154007778 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154007779 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 411154007780 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154007781 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154007782 dimer interface [polypeptide binding]; other site 411154007783 phosphorylation site [posttranslational modification] 411154007784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154007785 ATP binding site [chemical binding]; other site 411154007786 Mg2+ binding site [ion binding]; other site 411154007787 G-X-G motif; other site 411154007788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154007789 Response regulator receiver domain; Region: Response_reg; pfam00072 411154007790 active site 411154007791 phosphorylation site [posttranslational modification] 411154007792 intermolecular recognition site; other site 411154007793 dimerization interface [polypeptide binding]; other site 411154007794 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 411154007795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154007796 active site 411154007797 phosphorylation site [posttranslational modification] 411154007798 intermolecular recognition site; other site 411154007799 dimerization interface [polypeptide binding]; other site 411154007800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154007801 Walker A motif; other site 411154007802 ATP binding site [chemical binding]; other site 411154007803 Walker B motif; other site 411154007804 arginine finger; other site 411154007805 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 411154007806 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 411154007807 hypothetical protein; Provisional; Region: PRK09256 411154007808 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 411154007809 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 411154007810 AAA domain; Region: AAA_28; pfam13521 411154007811 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 411154007812 Domain of unknown function DUF77; Region: DUF77; cl00307 411154007813 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 411154007814 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 411154007815 PcrB family; Region: PcrB; pfam01884 411154007816 geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169 411154007817 phosphate binding site [ion binding]; other site 411154007818 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 411154007819 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 411154007820 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 411154007821 homotetramer interface [polypeptide binding]; other site 411154007822 ligand binding site [chemical binding]; other site 411154007823 catalytic site [active] 411154007824 NAD binding site [chemical binding]; other site 411154007825 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 411154007826 PEGA domain; Region: PEGA; pfam08308 411154007827 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 411154007828 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 411154007829 active site 411154007830 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 411154007831 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 411154007832 nudix motif; other site 411154007833 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 411154007834 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 411154007835 active site 411154007836 DNA binding site [nucleotide binding] 411154007837 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 411154007838 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 411154007839 active site 411154007840 PHP Thumb interface [polypeptide binding]; other site 411154007841 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 411154007842 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 411154007843 generic binding surface I; other site 411154007844 generic binding surface II; other site 411154007845 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 411154007846 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 411154007847 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 411154007848 catalytic motif [active] 411154007849 Catalytic residue [active] 411154007850 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 411154007851 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 411154007852 E3 interaction surface; other site 411154007853 lipoyl attachment site [posttranslational modification]; other site 411154007854 e3 binding domain; Region: E3_binding; pfam02817 411154007855 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 411154007856 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 411154007857 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 411154007858 TPP-binding site [chemical binding]; other site 411154007859 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 411154007860 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 411154007861 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 411154007862 substrate binding pocket [chemical binding]; other site 411154007863 chain length determination region; other site 411154007864 substrate-Mg2+ binding site; other site 411154007865 catalytic residues [active] 411154007866 aspartate-rich region 1; other site 411154007867 active site lid residues [active] 411154007868 aspartate-rich region 2; other site 411154007869 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 411154007870 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 411154007871 Outer membrane efflux protein; Region: OEP; pfam02321 411154007872 Outer membrane efflux protein; Region: OEP; pfam02321 411154007873 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 411154007874 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 411154007875 E3 interaction surface; other site 411154007876 lipoyl attachment site [posttranslational modification]; other site 411154007877 HlyD family secretion protein; Region: HlyD_3; pfam13437 411154007878 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 411154007879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 411154007880 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 411154007881 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 411154007882 dimer interface [polypeptide binding]; other site 411154007883 anticodon binding site; other site 411154007884 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 411154007885 homodimer interface [polypeptide binding]; other site 411154007886 motif 1; other site 411154007887 active site 411154007888 motif 2; other site 411154007889 GAD domain; Region: GAD; pfam02938 411154007890 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 411154007891 motif 3; other site 411154007892 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 411154007893 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 411154007894 Cl- selectivity filter; other site 411154007895 Cl- binding residues [ion binding]; other site 411154007896 pore gating glutamate residue; other site 411154007897 dimer interface [polypeptide binding]; other site 411154007898 FOG: CBS domain [General function prediction only]; Region: COG0517 411154007899 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 411154007900 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 411154007901 DNA-binding site [nucleotide binding]; DNA binding site 411154007902 RNA-binding motif; other site 411154007903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 411154007904 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 411154007905 NAD(P) binding site [chemical binding]; other site 411154007906 active site 411154007907 SnoaL-like domain; Region: SnoaL_3; pfam13474 411154007908 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 411154007909 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 411154007910 active site 411154007911 Zn binding site [ion binding]; other site 411154007912 hypothetical protein; Provisional; Region: PRK14686 411154007913 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 411154007914 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 411154007915 active site 411154007916 HIGH motif; other site 411154007917 KMSKS motif; other site 411154007918 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 411154007919 tRNA binding surface [nucleotide binding]; other site 411154007920 anticodon binding site; other site 411154007921 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 411154007922 dimer interface [polypeptide binding]; other site 411154007923 putative tRNA-binding site [nucleotide binding]; other site 411154007924 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 411154007925 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 411154007926 putative active site [active] 411154007927 Zn binding site [ion binding]; other site 411154007928 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 411154007929 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 411154007930 dimer interface [polypeptide binding]; other site 411154007931 ssDNA binding site [nucleotide binding]; other site 411154007932 tetramer (dimer of dimers) interface [polypeptide binding]; other site 411154007933 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 411154007934 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 411154007935 Methyltransferase domain; Region: Methyltransf_23; pfam13489 411154007936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154007937 S-adenosylmethionine binding site [chemical binding]; other site 411154007938 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 411154007939 FOG: CBS domain [General function prediction only]; Region: COG0517 411154007940 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 411154007941 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 411154007942 Peptidase family M28; Region: Peptidase_M28; pfam04389 411154007943 metal binding site [ion binding]; metal-binding site 411154007944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 411154007945 NADH(P)-binding; Region: NAD_binding_10; pfam13460 411154007946 NAD(P) binding site [chemical binding]; other site 411154007947 active site 411154007948 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 411154007949 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 411154007950 HflX GTPase family; Region: HflX; cd01878 411154007951 G1 box; other site 411154007952 GTP/Mg2+ binding site [chemical binding]; other site 411154007953 Switch I region; other site 411154007954 G2 box; other site 411154007955 G3 box; other site 411154007956 Switch II region; other site 411154007957 G4 box; other site 411154007958 G5 box; other site 411154007959 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 411154007960 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 411154007961 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 411154007962 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 411154007963 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 411154007964 active site 411154007965 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 411154007966 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 411154007967 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 411154007968 catalytic residue [active] 411154007969 FeS assembly protein SufD; Region: sufD; TIGR01981 411154007970 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 411154007971 FeS assembly ATPase SufC; Region: sufC; TIGR01978 411154007972 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 411154007973 Walker A/P-loop; other site 411154007974 ATP binding site [chemical binding]; other site 411154007975 Q-loop/lid; other site 411154007976 ABC transporter signature motif; other site 411154007977 Walker B; other site 411154007978 D-loop; other site 411154007979 H-loop/switch region; other site 411154007980 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 411154007981 putative ABC transporter; Region: ycf24; CHL00085 411154007982 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 411154007983 four helix bundle protein; Region: TIGR02436 411154007984 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 411154007985 thiamine-monophosphate kinase; Region: thiL; TIGR01379 411154007986 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 411154007987 ATP binding site [chemical binding]; other site 411154007988 dimerization interface [polypeptide binding]; other site 411154007989 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 411154007990 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 411154007991 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 411154007992 proline aminopeptidase P II; Provisional; Region: PRK10879 411154007993 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 411154007994 active site 411154007995 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 411154007996 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 411154007997 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 411154007998 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 411154007999 chaperone protein DnaJ; Provisional; Region: PRK14299 411154008000 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 411154008001 HSP70 interaction site [polypeptide binding]; other site 411154008002 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 411154008003 substrate binding site [polypeptide binding]; other site 411154008004 dimer interface [polypeptide binding]; other site 411154008005 DinB superfamily; Region: DinB_2; pfam12867 411154008006 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 411154008007 proximal heme binding site [chemical binding]; other site 411154008008 distal heme binding site [chemical binding]; other site 411154008009 putative dimer interface [polypeptide binding]; other site 411154008010 putative Iron-sulfur protein interface [polypeptide binding]; other site 411154008011 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 411154008012 L-aspartate oxidase; Provisional; Region: PRK06175 411154008013 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 411154008014 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 411154008015 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 411154008016 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 411154008017 methionine aminotransferase; Validated; Region: PRK09082 411154008018 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 411154008019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154008020 homodimer interface [polypeptide binding]; other site 411154008021 catalytic residue [active] 411154008022 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 411154008023 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 411154008024 putative active site [active] 411154008025 putative metal binding site [ion binding]; other site 411154008026 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 411154008027 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 411154008028 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 411154008029 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 411154008030 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 411154008031 classical (c) SDRs; Region: SDR_c; cd05233 411154008032 NAD(P) binding site [chemical binding]; other site 411154008033 active site 411154008034 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 411154008035 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 411154008036 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 411154008037 ATP binding site [chemical binding]; other site 411154008038 putative Mg++ binding site [ion binding]; other site 411154008039 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 411154008040 nucleotide binding region [chemical binding]; other site 411154008041 ATP-binding site [chemical binding]; other site 411154008042 TRCF domain; Region: TRCF; pfam03461 411154008043 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154008044 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154008045 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 411154008046 putative catalytic site [active] 411154008047 putative metal binding site [ion binding]; other site 411154008048 putative phosphate binding site [ion binding]; other site 411154008049 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154008050 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 411154008051 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154008052 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154008053 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 411154008054 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 411154008055 active site 411154008056 dimer interface [polypeptide binding]; other site 411154008057 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 411154008058 dimer interface [polypeptide binding]; other site 411154008059 active site 411154008060 putative peptidase; Provisional; Region: PRK11649 411154008061 Peptidase family M23; Region: Peptidase_M23; pfam01551 411154008062 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 411154008063 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 411154008064 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 411154008065 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 411154008066 dimer interface [polypeptide binding]; other site 411154008067 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 411154008068 active site 411154008069 Fe binding site [ion binding]; other site 411154008070 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 411154008071 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 411154008072 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 411154008073 active site 411154008074 nucleophile elbow; other site 411154008075 Surface antigen; Region: Bac_surface_Ag; pfam01103 411154008076 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 411154008077 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 411154008078 GIY-YIG motif/motif A; other site 411154008079 active site 411154008080 catalytic site [active] 411154008081 putative DNA binding site [nucleotide binding]; other site 411154008082 metal binding site [ion binding]; metal-binding site 411154008083 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 411154008084 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 411154008085 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 411154008086 ATP-grasp domain; Region: ATP-grasp_4; cl17255 411154008087 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 411154008088 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 411154008089 putative active site [active] 411154008090 Zn binding site [ion binding]; other site 411154008091 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 411154008092 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 411154008093 PAS fold; Region: PAS_3; pfam08447 411154008094 PAS fold; Region: PAS_3; pfam08447 411154008095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 411154008096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154008097 ATP binding site [chemical binding]; other site 411154008098 Mg2+ binding site [ion binding]; other site 411154008099 G-X-G motif; other site 411154008100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154008101 Response regulator receiver domain; Region: Response_reg; pfam00072 411154008102 active site 411154008103 phosphorylation site [posttranslational modification] 411154008104 intermolecular recognition site; other site 411154008105 dimerization interface [polypeptide binding]; other site 411154008106 lipoprotein signal peptidase; Provisional; Region: PRK14788 411154008107 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 411154008108 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 411154008109 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 411154008110 active site 411154008111 HIGH motif; other site 411154008112 nucleotide binding site [chemical binding]; other site 411154008113 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 411154008114 active site 411154008115 KMSKS motif; other site 411154008116 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 411154008117 tRNA binding surface [nucleotide binding]; other site 411154008118 anticodon binding site; other site 411154008119 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154008120 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 411154008121 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 411154008122 N-terminal plug; other site 411154008123 ligand-binding site [chemical binding]; other site 411154008124 Recombination protein O N terminal; Region: RecO_N; pfam11967 411154008125 DNA repair protein RecO; Region: reco; TIGR00613 411154008126 Recombination protein O C terminal; Region: RecO_C; pfam02565 411154008127 glutamate dehydrogenase; Provisional; Region: PRK09414 411154008128 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 411154008129 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 411154008130 NAD(P) binding site [chemical binding]; other site 411154008131 OmpW family; Region: OmpW; cl17427 411154008132 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 411154008133 Isochorismatase family; Region: Isochorismatase; pfam00857 411154008134 catalytic triad [active] 411154008135 metal binding site [ion binding]; metal-binding site 411154008136 conserved cis-peptide bond; other site 411154008137 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 411154008138 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 411154008139 active site 411154008140 Phosphate transporter family; Region: PHO4; pfam01384 411154008141 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 411154008142 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 411154008143 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 411154008144 active site 411154008145 catalytic site [active] 411154008146 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 411154008147 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 411154008148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 411154008149 binding surface 411154008150 TPR motif; other site 411154008151 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 411154008152 RIP metalloprotease RseP; Region: TIGR00054 411154008153 active site 411154008154 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 411154008155 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 411154008156 protein binding site [polypeptide binding]; other site 411154008157 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 411154008158 putative substrate binding region [chemical binding]; other site 411154008159 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 411154008160 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 411154008161 Cu(I) binding site [ion binding]; other site 411154008162 FeoA domain; Region: FeoA; pfam04023 411154008163 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 411154008164 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 411154008165 G1 box; other site 411154008166 GTP/Mg2+ binding site [chemical binding]; other site 411154008167 Switch I region; other site 411154008168 G2 box; other site 411154008169 G3 box; other site 411154008170 Switch II region; other site 411154008171 G4 box; other site 411154008172 G5 box; other site 411154008173 Nucleoside recognition; Region: Gate; pfam07670 411154008174 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 411154008175 Nucleoside recognition; Region: Gate; pfam07670 411154008176 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 411154008177 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 411154008178 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 411154008179 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 411154008180 FeoA domain; Region: FeoA; pfam04023 411154008181 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154008182 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 411154008183 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 411154008184 N-terminal plug; other site 411154008185 ligand-binding site [chemical binding]; other site 411154008186 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 411154008187 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 411154008188 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 411154008189 putative metal binding site [ion binding]; other site 411154008190 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 411154008191 HSP70 interaction site [polypeptide binding]; other site 411154008192 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 411154008193 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 411154008194 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 411154008195 putative acyl-acceptor binding pocket; other site 411154008196 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 411154008197 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 411154008198 Zn2+ binding site [ion binding]; other site 411154008199 Mg2+ binding site [ion binding]; other site 411154008200 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 411154008201 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 411154008202 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 411154008203 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_4; cd08976 411154008204 putative DNA binding site [nucleotide binding]; other site 411154008205 catalytic residue [active] 411154008206 putative H2TH interface [polypeptide binding]; other site 411154008207 putative catalytic residues [active] 411154008208 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 411154008209 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 411154008210 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 411154008211 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 411154008212 FeS/SAM binding site; other site 411154008213 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 411154008214 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 411154008215 substrate binding site [chemical binding]; other site 411154008216 oxyanion hole (OAH) forming residues; other site 411154008217 trimer interface [polypeptide binding]; other site 411154008218 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 411154008219 HAMP domain; Region: HAMP; pfam00672 411154008220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 411154008221 dimer interface [polypeptide binding]; other site 411154008222 phosphorylation site [posttranslational modification] 411154008223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 411154008224 ATP binding site [chemical binding]; other site 411154008225 Mg2+ binding site [ion binding]; other site 411154008226 G-X-G motif; other site 411154008227 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 411154008228 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 411154008229 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 411154008230 Asp-box motif; other site 411154008231 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 411154008232 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 411154008233 ferrochelatase; Reviewed; Region: hemH; PRK00035 411154008234 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 411154008235 C-terminal domain interface [polypeptide binding]; other site 411154008236 active site 411154008237 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 411154008238 active site 411154008239 N-terminal domain interface [polypeptide binding]; other site 411154008240 Trehalose utilisation; Region: ThuA; pfam06283 411154008241 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 411154008242 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 411154008243 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 411154008244 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 411154008245 tRNA; other site 411154008246 putative tRNA binding site [nucleotide binding]; other site 411154008247 putative NADP binding site [chemical binding]; other site 411154008248 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 411154008249 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 411154008250 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 411154008251 domain interfaces; other site 411154008252 active site 411154008253 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 411154008254 active site 411154008255 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 411154008256 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 411154008257 substrate binding site [chemical binding]; other site 411154008258 active site 411154008259 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 411154008260 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 411154008261 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 411154008262 four helix bundle protein; Region: TIGR02436 411154008263 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 411154008264 dimer interface [polypeptide binding]; other site 411154008265 allosteric magnesium binding site [ion binding]; other site 411154008266 active site 411154008267 aspartate-rich active site metal binding site; other site 411154008268 Schiff base residues; other site 411154008269 Domain of unknown function DUF21; Region: DUF21; pfam01595 411154008270 FOG: CBS domain [General function prediction only]; Region: COG0517 411154008271 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 411154008272 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 411154008273 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 411154008274 DNA binding site [nucleotide binding] 411154008275 active site 411154008276 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 411154008277 Beta-lactamase; Region: Beta-lactamase; pfam00144 411154008278 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 411154008279 active site 411154008280 catalytic site [active] 411154008281 substrate binding site [chemical binding]; other site 411154008282 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 411154008283 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 411154008284 four helix bundle protein; Region: TIGR02436 411154008285 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 411154008286 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 411154008287 Transglycosylase; Region: Transgly; pfam00912 411154008288 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 411154008289 GldH lipoprotein; Region: GldH_lipo; pfam14109 411154008290 PSP1 C-terminal conserved region; Region: PSP1; cl00770 411154008291 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 411154008292 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 411154008293 active site residue [active] 411154008294 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 411154008295 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 411154008296 hexamer interface [polypeptide binding]; other site 411154008297 Walker A motif; other site 411154008298 ATP binding site [chemical binding]; other site 411154008299 Walker B motif; other site 411154008300 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 411154008301 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 411154008302 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 411154008303 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 411154008304 DNA binding residues [nucleotide binding] 411154008305 Anti-sigma-K factor rskA; Region: RskA; pfam10099 411154008306 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 411154008307 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 411154008308 putative acyl-acceptor binding pocket; other site 411154008309 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 411154008310 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 411154008311 active site 411154008312 HIGH motif; other site 411154008313 dimer interface [polypeptide binding]; other site 411154008314 KMSKS motif; other site 411154008315 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 411154008316 DNA protecting protein DprA; Region: dprA; TIGR00732 411154008317 Sporulation related domain; Region: SPOR; cl10051 411154008318 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 411154008319 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 411154008320 Peptidase family M23; Region: Peptidase_M23; pfam01551 411154008321 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 411154008322 TPR repeat; Region: TPR_11; pfam13414 411154008323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154008324 binding surface 411154008325 TPR motif; other site 411154008326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 411154008327 TPR motif; other site 411154008328 binding surface 411154008329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154008330 binding surface 411154008331 TPR motif; other site 411154008332 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 411154008333 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 411154008334 active site 411154008335 Substrate binding site; other site 411154008336 Mg++ binding site; other site 411154008337 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 411154008338 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 411154008339 trimer interface [polypeptide binding]; other site 411154008340 active site 411154008341 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 411154008342 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 411154008343 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 411154008344 core domain interface [polypeptide binding]; other site 411154008345 delta subunit interface [polypeptide binding]; other site 411154008346 epsilon subunit interface [polypeptide binding]; other site 411154008347 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 411154008348 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 411154008349 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 411154008350 beta subunit interaction interface [polypeptide binding]; other site 411154008351 Walker A motif; other site 411154008352 ATP binding site [chemical binding]; other site 411154008353 Walker B motif; other site 411154008354 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 411154008355 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 411154008356 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 411154008357 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471 411154008358 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 411154008359 ATP synthase subunit C; Region: ATP-synt_C; cl00466 411154008360 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 411154008361 ATP synthase A chain; Region: ATP-synt_A; cl00413 411154008362 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 411154008363 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 411154008364 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 411154008365 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 411154008366 Walker A/P-loop; other site 411154008367 ATP binding site [chemical binding]; other site 411154008368 Q-loop/lid; other site 411154008369 ABC transporter signature motif; other site 411154008370 Walker B; other site 411154008371 D-loop; other site 411154008372 H-loop/switch region; other site 411154008373 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 411154008374 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 411154008375 FAD binding pocket [chemical binding]; other site 411154008376 FAD binding motif [chemical binding]; other site 411154008377 phosphate binding motif [ion binding]; other site 411154008378 beta-alpha-beta structure motif; other site 411154008379 NAD(p) ribose binding residues [chemical binding]; other site 411154008380 NAD binding pocket [chemical binding]; other site 411154008381 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 411154008382 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 411154008383 catalytic loop [active] 411154008384 iron binding site [ion binding]; other site 411154008385 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 411154008386 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 411154008387 putative active site [active] 411154008388 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 411154008389 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 411154008390 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 411154008391 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 411154008392 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 411154008393 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 411154008394 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 411154008395 AMP binding site [chemical binding]; other site 411154008396 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 411154008397 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 411154008398 active site 411154008399 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 411154008400 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 411154008401 NAD binding site [chemical binding]; other site 411154008402 putative substrate binding site 2 [chemical binding]; other site 411154008403 putative substrate binding site 1 [chemical binding]; other site 411154008404 active site 411154008405 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 411154008406 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 411154008407 NADP binding site [chemical binding]; other site 411154008408 active site 411154008409 putative substrate binding site [chemical binding]; other site 411154008410 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 411154008411 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 411154008412 GH3 auxin-responsive promoter; Region: GH3; pfam03321 411154008413 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 411154008414 Peptidase family M23; Region: Peptidase_M23; pfam01551 411154008415 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 411154008416 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 411154008417 N-acetyl-D-glucosamine binding site [chemical binding]; other site 411154008418 catalytic residue [active] 411154008419 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 411154008420 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 411154008421 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 411154008422 Phosphoglycerate kinase; Region: PGK; pfam00162 411154008423 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 411154008424 substrate binding site [chemical binding]; other site 411154008425 hinge regions; other site 411154008426 ADP binding site [chemical binding]; other site 411154008427 catalytic site [active] 411154008428 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 411154008429 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 411154008430 DNA polymerase III subunit delta'; Validated; Region: PRK08485 411154008431 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 411154008432 Methyltransferase domain; Region: Methyltransf_23; pfam13489 411154008433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154008434 S-adenosylmethionine binding site [chemical binding]; other site 411154008435 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 411154008436 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 411154008437 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 411154008438 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 411154008439 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 411154008440 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 411154008441 HIGH motif; other site 411154008442 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 411154008443 active site 411154008444 KMSKS motif; other site 411154008445 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 411154008446 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 411154008447 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 411154008448 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 411154008449 active site 411154008450 HIGH motif; other site 411154008451 nucleotide binding site [chemical binding]; other site 411154008452 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 411154008453 active site 411154008454 KMSKS motif; other site 411154008455 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 411154008456 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 411154008457 Dihydroneopterin aldolase; Region: FolB; smart00905 411154008458 active site 411154008459 LysE type translocator; Region: LysE; cl00565 411154008460 ribonuclease R; Region: RNase_R; TIGR02063 411154008461 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 411154008462 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 411154008463 RNB domain; Region: RNB; pfam00773 411154008464 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 411154008465 RNA binding site [nucleotide binding]; other site 411154008466 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 411154008467 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 411154008468 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 411154008469 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 411154008470 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 411154008471 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 411154008472 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 411154008473 protein binding site [polypeptide binding]; other site 411154008474 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 411154008475 Catalytic dyad [active] 411154008476 ribonuclease P; Reviewed; Region: rnpA; PRK01903 411154008477 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 411154008478 Zn binding site [ion binding]; other site 411154008479 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 411154008480 Peptidase S8 family domain in Subtilisin_Novo-like proteins; Region: Peptidases_S8_Subtilisin_Novo-like; cd07483 411154008481 active site 411154008482 catalytic triad [active] 411154008483 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 411154008484 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 411154008485 TrkA-N domain; Region: TrkA_N; pfam02254 411154008486 hypothetical protein; Validated; Region: PRK00110 411154008487 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 411154008488 four helix bundle protein; Region: TIGR02436 411154008489 GTP-binding protein LepA; Provisional; Region: PRK05433 411154008490 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 411154008491 G1 box; other site 411154008492 putative GEF interaction site [polypeptide binding]; other site 411154008493 GTP/Mg2+ binding site [chemical binding]; other site 411154008494 Switch I region; other site 411154008495 G2 box; other site 411154008496 G3 box; other site 411154008497 Switch II region; other site 411154008498 G4 box; other site 411154008499 G5 box; other site 411154008500 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 411154008501 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 411154008502 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 411154008503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154008504 glucose/galactose transporter; Region: gluP; TIGR01272 411154008505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 411154008506 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 411154008507 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 411154008508 putative active site [active] 411154008509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 411154008510 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 411154008511 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 411154008512 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 411154008513 active site 411154008514 Bacterial SH3 domain; Region: SH3_4; pfam06347 411154008515 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 411154008516 NlpC/P60 family; Region: NLPC_P60; pfam00877 411154008517 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 411154008518 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154008519 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 411154008520 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 411154008521 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 411154008522 FMN binding site [chemical binding]; other site 411154008523 active site 411154008524 catalytic residues [active] 411154008525 substrate binding site [chemical binding]; other site 411154008526 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 411154008527 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 411154008528 FtsX-like permease family; Region: FtsX; pfam02687 411154008529 Ribosome-binding factor A; Region: RBFA; pfam02033 411154008530 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 411154008531 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 411154008532 dimer interface [polypeptide binding]; other site 411154008533 substrate binding site [chemical binding]; other site 411154008534 metal binding site [ion binding]; metal-binding site 411154008535 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 411154008536 Lumazine binding domain; Region: Lum_binding; pfam00677 411154008537 Lumazine binding domain; Region: Lum_binding; pfam00677 411154008538 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 411154008539 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 411154008540 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 411154008541 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 411154008542 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 411154008543 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 411154008544 dimer interface [polypeptide binding]; other site 411154008545 active site 411154008546 CoA binding pocket [chemical binding]; other site 411154008547 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 411154008548 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 411154008549 carboxyltransferase (CT) interaction site; other site 411154008550 biotinylation site [posttranslational modification]; other site 411154008551 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 411154008552 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 411154008553 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 411154008554 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 411154008555 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 411154008556 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 411154008557 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 411154008558 Transglycosylase; Region: Transgly; cl17702 411154008559 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 411154008560 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 411154008561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 411154008562 Walker A/P-loop; other site 411154008563 ATP binding site [chemical binding]; other site 411154008564 Q-loop/lid; other site 411154008565 ABC transporter signature motif; other site 411154008566 Walker B; other site 411154008567 D-loop; other site 411154008568 H-loop/switch region; other site 411154008569 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 411154008570 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 411154008571 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 411154008572 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 411154008573 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 411154008574 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 411154008575 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 411154008576 active site 411154008577 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 411154008578 dimer interface [polypeptide binding]; other site 411154008579 substrate binding site [chemical binding]; other site 411154008580 catalytic residues [active] 411154008581 thymidine kinase; Provisional; Region: PRK04296 411154008582 Predicted methyltransferases [General function prediction only]; Region: COG0313 411154008583 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 411154008584 putative SAM binding site [chemical binding]; other site 411154008585 putative homodimer interface [polypeptide binding]; other site 411154008586 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 411154008587 putative uracil binding site [chemical binding]; other site 411154008588 putative active site [active] 411154008589 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 411154008590 AAA domain; Region: AAA_14; pfam13173 411154008591 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 411154008592 DHH family; Region: DHH; pfam01368 411154008593 DHHA1 domain; Region: DHHA1; pfam02272 411154008594 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 411154008595 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 411154008596 putative active site [active] 411154008597 putative metal binding site [ion binding]; other site 411154008598 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 411154008599 active site 411154008600 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 411154008601 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 411154008602 Man1-Src1p-C-terminal domain; Region: MSC; pfam09402 411154008603 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 411154008604 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 411154008605 substrate binding site [chemical binding]; other site 411154008606 oxyanion hole (OAH) forming residues; other site 411154008607 trimer interface [polypeptide binding]; other site 411154008608 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 411154008609 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 411154008610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 411154008611 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 411154008612 Coenzyme A binding pocket [chemical binding]; other site 411154008613 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 411154008614 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 411154008615 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 411154008616 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 411154008617 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 411154008618 ligand binding site [chemical binding]; other site 411154008619 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 411154008620 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 411154008621 substrate-cofactor binding pocket; other site 411154008622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154008623 catalytic residue [active] 411154008624 Part of AAA domain; Region: AAA_19; pfam13245 411154008625 putative recombination protein RecB; Provisional; Region: PRK13909 411154008626 Family description; Region: UvrD_C_2; pfam13538 411154008627 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 411154008628 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 411154008629 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 411154008630 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 411154008631 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 411154008632 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 411154008633 active site 411154008634 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 411154008635 active site 411154008636 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 411154008637 Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946 411154008638 substrate binding site [chemical binding]; other site 411154008639 ATP binding site [chemical binding]; other site 411154008640 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 411154008641 RNA/DNA hybrid binding site [nucleotide binding]; other site 411154008642 active site 411154008643 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 411154008644 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 411154008645 active site 411154008646 substrate binding site [chemical binding]; other site 411154008647 cosubstrate binding site; other site 411154008648 catalytic site [active] 411154008649 acyl carrier protein; Provisional; Region: acpP; PRK00982 411154008650 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 411154008651 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 411154008652 dimer interface [polypeptide binding]; other site 411154008653 active site 411154008654 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 411154008655 dimerization interface [polypeptide binding]; other site 411154008656 active site 411154008657 metal binding site [ion binding]; metal-binding site 411154008658 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 411154008659 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 411154008660 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 411154008661 domain interfaces; other site 411154008662 active site 411154008663 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 411154008664 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 411154008665 active site 411154008666 DNA polymerase IV; Validated; Region: PRK02406 411154008667 DNA binding site [nucleotide binding] 411154008668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 411154008669 NADH(P)-binding; Region: NAD_binding_10; pfam13460 411154008670 NAD(P) binding site [chemical binding]; other site 411154008671 active site 411154008672 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 411154008673 putative active site [active] 411154008674 putative metal binding residues [ion binding]; other site 411154008675 signature motif; other site 411154008676 putative dimer interface [polypeptide binding]; other site 411154008677 putative phosphate binding site [ion binding]; other site 411154008678 YCII-related domain; Region: YCII; cl00999 411154008679 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 411154008680 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 411154008681 catalytic residues [active] 411154008682 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 411154008683 PAP2 superfamily; Region: PAP2; pfam01569 411154008684 active site 411154008685 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 411154008686 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 411154008687 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 411154008688 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 411154008689 HlyD family secretion protein; Region: HlyD_3; pfam13437 411154008690 Predicted transcriptional regulators [Transcription]; Region: COG1510 411154008691 MarR family; Region: MarR_2; cl17246 411154008692 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 411154008693 catalytic nucleophile [active] 411154008694 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 411154008695 aldehyde dehydrogenase family 7 member; Region: PLN02315 411154008696 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 411154008697 tetrameric interface [polypeptide binding]; other site 411154008698 NAD binding site [chemical binding]; other site 411154008699 catalytic residues [active] 411154008700 Uncharacterized conserved protein [Function unknown]; Region: COG3339 411154008701 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 411154008702 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 411154008703 homodimer interface [polypeptide binding]; other site 411154008704 putative substrate binding pocket [chemical binding]; other site 411154008705 diiron center [ion binding]; other site 411154008706 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 411154008707 active site 411154008708 metal binding site [ion binding]; metal-binding site 411154008709 Divergent AAA domain; Region: AAA_4; pfam04326 411154008710 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 411154008711 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 411154008712 putative NAD(P) binding site [chemical binding]; other site 411154008713 homotetramer interface [polypeptide binding]; other site 411154008714 homodimer interface [polypeptide binding]; other site 411154008715 active site 411154008716 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 411154008717 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 411154008718 MoxR-like ATPases [General function prediction only]; Region: COG0714 411154008719 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 411154008720 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 411154008721 Protein of unknown function DUF58; Region: DUF58; pfam01882 411154008722 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 411154008723 metal ion-dependent adhesion site (MIDAS); other site 411154008724 Oxygen tolerance; Region: BatD; pfam13584 411154008725 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 411154008726 metal ion-dependent adhesion site (MIDAS); other site 411154008727 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 411154008728 metal ion-dependent adhesion site (MIDAS); other site 411154008729 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154008730 binding surface 411154008731 TPR motif; other site 411154008732 Tetratricopeptide repeat; Region: TPR_12; pfam13424 411154008733 Oxygen tolerance; Region: BatD; pfam13584 411154008734 TPR repeat; Region: TPR_11; pfam13414 411154008735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154008736 binding surface 411154008737 TPR motif; other site 411154008738 Bacterial SH3 domain homologues; Region: SH3b; smart00287 411154008739 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 411154008740 Sulfate transporter family; Region: Sulfate_transp; pfam00916 411154008741 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 411154008742 active site clefts [active] 411154008743 zinc binding site [ion binding]; other site 411154008744 dimer interface [polypeptide binding]; other site 411154008745 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 411154008746 Colicin V production protein; Region: Colicin_V; pfam02674 411154008747 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 411154008748 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 411154008749 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 411154008750 dimer interface [polypeptide binding]; other site 411154008751 motif 1; other site 411154008752 active site 411154008753 motif 2; other site 411154008754 motif 3; other site 411154008755 LVIVD repeat; Region: LVIVD; pfam08309 411154008756 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 411154008757 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 411154008758 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 411154008759 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 411154008760 BON domain; Region: BON; pfam04972 411154008761 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 411154008762 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 411154008763 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 411154008764 active site 411154008765 (T/H)XGH motif; other site 411154008766 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 411154008767 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 411154008768 catalytic site [active] 411154008769 G-X2-G-X-G-K; other site 411154008770 hypothetical protein; Provisional; Region: PRK11820 411154008771 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 411154008772 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 411154008773 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 411154008774 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 411154008775 active site 411154008776 EamA-like transporter family; Region: EamA; pfam00892 411154008777 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 411154008778 EamA-like transporter family; Region: EamA; pfam00892 411154008779 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 411154008780 ArsC family; Region: ArsC; pfam03960 411154008781 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 411154008782 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 411154008783 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 411154008784 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 411154008785 homodimer interface [polypeptide binding]; other site 411154008786 substrate-cofactor binding pocket; other site 411154008787 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154008788 catalytic residue [active] 411154008789 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 411154008790 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 411154008791 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 411154008792 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 411154008793 catalytic residue [active] 411154008794 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 411154008795 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 411154008796 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 411154008797 oligomer interface [polypeptide binding]; other site 411154008798 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 411154008799 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 411154008800 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 411154008801 Peptidase family M28; Region: Peptidase_M28; pfam04389 411154008802 metal binding site [ion binding]; metal-binding site 411154008803 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 411154008804 Uncharacterized conserved protein [Function unknown]; Region: COG3342 411154008805 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 411154008806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154008807 binding surface 411154008808 TPR motif; other site 411154008809 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 411154008810 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 411154008811 active site 411154008812 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 411154008813 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 411154008814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 411154008815 active site 411154008816 phosphorylation site [posttranslational modification] 411154008817 intermolecular recognition site; other site 411154008818 dimerization interface [polypeptide binding]; other site 411154008819 LytTr DNA-binding domain; Region: LytTR; smart00850 411154008820 Histidine kinase; Region: His_kinase; pfam06580 411154008821 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 411154008822 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 411154008823 motif II; other site 411154008824 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 411154008825 Surface antigen; Region: Bac_surface_Ag; pfam01103 411154008826 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 411154008827 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 411154008828 dimerization interface [polypeptide binding]; other site 411154008829 DNA binding residues [nucleotide binding] 411154008830 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 411154008831 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154008832 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 411154008833 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 411154008834 starch binding outer membrane protein SusD; Region: SusD; cd08977 411154008835 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 411154008836 active site 411154008837 catalytic residues [active] 411154008838 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 411154008839 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 411154008840 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 411154008841 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 411154008842 active site 411154008843 catalytic residues [active] 411154008844 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 411154008845 nucleoside/Zn binding site; other site 411154008846 dimer interface [polypeptide binding]; other site 411154008847 catalytic motif [active] 411154008848 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 411154008849 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 411154008850 TPP-binding site; other site 411154008851 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 411154008852 PYR/PP interface [polypeptide binding]; other site 411154008853 dimer interface [polypeptide binding]; other site 411154008854 TPP binding site [chemical binding]; other site 411154008855 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 411154008856 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 411154008857 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 411154008858 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 411154008859 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 411154008860 putative active site [active] 411154008861 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 411154008862 ATP cone domain; Region: ATP-cone; pfam03477 411154008863 Class I ribonucleotide reductase; Region: RNR_I; cd01679 411154008864 active site 411154008865 dimer interface [polypeptide binding]; other site 411154008866 catalytic residues [active] 411154008867 effector binding site; other site 411154008868 R2 peptide binding site; other site 411154008869 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 411154008870 dimer interface [polypeptide binding]; other site 411154008871 putative radical transfer pathway; other site 411154008872 diiron center [ion binding]; other site 411154008873 tyrosyl radical; other site 411154008874 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 411154008875 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 411154008876 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 411154008877 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 411154008878 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 411154008879 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 411154008880 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 411154008881 protein binding site [polypeptide binding]; other site 411154008882 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 411154008883 Catalytic dyad [active] 411154008884 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 411154008885 catalytic motif [active] 411154008886 Zn binding site [ion binding]; other site 411154008887 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 411154008888 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 411154008889 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 411154008890 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 411154008891 DNA binding residues [nucleotide binding] 411154008892 dimerization interface [polypeptide binding]; other site 411154008893 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 411154008894 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 411154008895 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 411154008896 Ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding domain of the alpha/beta class and a discrete (usually N-terminal) domain which varies in orientation with respect to the NAD(P) binding domain. The N-terminal region...; Region: FNR_like_1; cd06196 411154008897 FAD binding pocket [chemical binding]; other site 411154008898 FAD binding motif [chemical binding]; other site 411154008899 phosphate binding motif [ion binding]; other site 411154008900 beta-alpha-beta structure motif; other site 411154008901 NAD binding pocket [chemical binding]; other site 411154008902 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 411154008903 putative hydrophobic ligand binding site [chemical binding]; other site 411154008904 Methyltransferase domain; Region: Methyltransf_31; pfam13847 411154008905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154008906 S-adenosylmethionine binding site [chemical binding]; other site 411154008907 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 411154008908 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 411154008909 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 411154008910 active site 411154008911 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 411154008912 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 411154008913 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 411154008914 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 411154008915 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 411154008916 5S rRNA interface [nucleotide binding]; other site 411154008917 CTC domain interface [polypeptide binding]; other site 411154008918 L16 interface [polypeptide binding]; other site 411154008919 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 411154008920 putative active site [active] 411154008921 catalytic residue [active] 411154008922 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 411154008923 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 411154008924 active site 411154008925 Riboflavin kinase; Region: Flavokinase; pfam01687 411154008926 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 411154008927 seryl-tRNA synthetase; Provisional; Region: PRK05431 411154008928 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 411154008929 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 411154008930 dimer interface [polypeptide binding]; other site 411154008931 active site 411154008932 motif 1; other site 411154008933 motif 2; other site 411154008934 motif 3; other site 411154008935 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 411154008936 binding surface 411154008937 TPR motif; other site 411154008938 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 411154008939 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 411154008940 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 411154008941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154008942 S-adenosylmethionine binding site [chemical binding]; other site 411154008943 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 411154008944 MgtE intracellular N domain; Region: MgtE_N; smart00924 411154008945 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 411154008946 Divalent cation transporter; Region: MgtE; pfam01769 411154008947 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 411154008948 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_14; cd12179 411154008949 putative ligand binding site [chemical binding]; other site 411154008950 putative NAD binding site [chemical binding]; other site 411154008951 catalytic site [active] 411154008952 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 411154008953 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 411154008954 NADH(P)-binding; Region: NAD_binding_10; pfam13460 411154008955 NAD(P) binding site [chemical binding]; other site 411154008956 putative active site [active] 411154008957 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 411154008958 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 411154008959 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 411154008960 putative acyl-acceptor binding pocket; other site 411154008961 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 411154008962 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 411154008963 Pyrococcus aspartate kinase subunit, putative; Region: AspKin_pair; TIGR02078 411154008964 nucleotide binding site [chemical binding]; other site 411154008965 substrate binding site [chemical binding]; other site 411154008966 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 411154008967 Coenzyme A binding pocket [chemical binding]; other site 411154008968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 411154008969 Coenzyme A binding pocket [chemical binding]; other site 411154008970 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 411154008971 AMP binding site [chemical binding]; other site 411154008972 metal binding site [ion binding]; metal-binding site 411154008973 active site 411154008974 tellurium resistance terB-like protein; Region: terB_like; cd07177 411154008975 metal binding site [ion binding]; metal-binding site 411154008976 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 411154008977 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 411154008978 ATP-dependent DNA ligase; Validated; Region: PRK09247 411154008979 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 411154008980 active site 411154008981 DNA binding site [nucleotide binding] 411154008982 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 411154008983 DNA binding site [nucleotide binding] 411154008984 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 411154008985 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 411154008986 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 411154008987 ATP binding site [chemical binding]; other site 411154008988 putative Mg++ binding site [ion binding]; other site 411154008989 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 411154008990 nucleotide binding region [chemical binding]; other site 411154008991 ATP-binding site [chemical binding]; other site 411154008992 DEAD/H associated; Region: DEAD_assoc; pfam08494 411154008993 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 411154008994 C-N hydrolase family amidase; Provisional; Region: PRK10438 411154008995 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 411154008996 putative active site [active] 411154008997 catalytic triad [active] 411154008998 dimer interface [polypeptide binding]; other site 411154008999 multimer interface [polypeptide binding]; other site 411154009000 Bacterial Ig-like domain; Region: Big_5; pfam13205 411154009001 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 411154009002 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 411154009003 active site 411154009004 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 411154009005 glycyl-tRNA synthetase; Provisional; Region: PRK04173 411154009006 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 411154009007 motif 1; other site 411154009008 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 411154009009 active site 411154009010 motif 2; other site 411154009011 motif 3; other site 411154009012 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 411154009013 anticodon binding site; other site 411154009014 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 411154009015 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 411154009016 putative active site [active] 411154009017 putative catalytic site [active] 411154009018 putative DNA binding site [nucleotide binding]; other site 411154009019 putative phosphate binding site [ion binding]; other site 411154009020 metal binding site A [ion binding]; metal-binding site 411154009021 putative AP binding site [nucleotide binding]; other site 411154009022 putative metal binding site B [ion binding]; other site 411154009023 hypothetical protein; Validated; Region: PRK09039 411154009024 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 411154009025 ligand binding site [chemical binding]; other site 411154009026 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 411154009027 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 411154009028 active site 411154009029 catalytic tetrad [active] 411154009030 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 411154009031 Peptidase family M23; Region: Peptidase_M23; pfam01551 411154009032 DNA repair protein RadA; Provisional; Region: PRK11823 411154009033 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 411154009034 Walker A motif/ATP binding site; other site 411154009035 ATP binding site [chemical binding]; other site 411154009036 Walker B motif; other site 411154009037 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 411154009038 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 411154009039 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 411154009040 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 411154009041 tetramerization interface [polypeptide binding]; other site 411154009042 active site 411154009043 pantoate--beta-alanine ligase; Region: panC; TIGR00018 411154009044 Pantoate-beta-alanine ligase; Region: PanC; cd00560 411154009045 active site 411154009046 ATP-binding site [chemical binding]; other site 411154009047 pantoate-binding site; other site 411154009048 HXXH motif; other site 411154009049 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 411154009050 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 411154009051 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 411154009052 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 411154009053 glutaminase active site [active] 411154009054 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 411154009055 dimer interface [polypeptide binding]; other site 411154009056 active site 411154009057 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 411154009058 dimer interface [polypeptide binding]; other site 411154009059 active site 411154009060 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 411154009061 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 411154009062 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 411154009063 alpha subunit interaction interface [polypeptide binding]; other site 411154009064 Walker A motif; other site 411154009065 ATP binding site [chemical binding]; other site 411154009066 Walker B motif; other site 411154009067 inhibitor binding site; inhibition site 411154009068 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 411154009069 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 411154009070 gamma subunit interface [polypeptide binding]; other site 411154009071 LBP interface [polypeptide binding]; other site 411154009072 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 411154009073 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 411154009074 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 411154009075 protein binding site [polypeptide binding]; other site 411154009076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 411154009077 non-specific DNA binding site [nucleotide binding]; other site 411154009078 salt bridge; other site 411154009079 sequence-specific DNA binding site [nucleotide binding]; other site 411154009080 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 411154009081 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 411154009082 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 411154009083 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 411154009084 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509 411154009085 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12659 411154009086 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 411154009087 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 411154009088 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 411154009089 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 411154009090 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 411154009091 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 411154009092 MgtC family; Region: MgtC; pfam02308 411154009093 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 411154009094 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 411154009095 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 411154009096 catalytic residue [active] 411154009097 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 411154009098 AAA domain; Region: AAA_26; pfam13500 411154009099 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 411154009100 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 411154009101 inhibitor-cofactor binding pocket; inhibition site 411154009102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 411154009103 catalytic residue [active] 411154009104 SET domain; Region: SET; pfam00856 411154009105 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 411154009106 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 411154009107 active site 411154009108 biotin synthase; Region: bioB; TIGR00433 411154009109 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 411154009110 FeS/SAM binding site; other site 411154009111 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 411154009112 Cupin-like domain; Region: Cupin_8; pfam13621 411154009113 Cupin-like domain; Region: Cupin_8; pfam13621 411154009114 RecX family; Region: RecX; pfam02631 411154009115 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 411154009116 dimerization interface [polypeptide binding]; other site 411154009117 metal binding site [ion binding]; metal-binding site 411154009118 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 411154009119 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 411154009120 homodimer interface [polypeptide binding]; other site 411154009121 oligonucleotide binding site [chemical binding]; other site 411154009122 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 411154009123 IHF - DNA interface [nucleotide binding]; other site 411154009124 IHF dimer interface [polypeptide binding]; other site 411154009125 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 411154009126 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 411154009127 minor groove reading motif; other site 411154009128 helix-hairpin-helix signature motif; other site 411154009129 substrate binding pocket [chemical binding]; other site 411154009130 active site 411154009131 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 411154009132 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 411154009133 DNA binding and oxoG recognition site [nucleotide binding] 411154009134 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 411154009135 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 411154009136 dimer interface [polypeptide binding]; other site 411154009137 ssDNA binding site [nucleotide binding]; other site 411154009138 tetramer (dimer of dimers) interface [polypeptide binding]; other site 411154009139 gliding motility-associated protein GldE; Region: GldE; TIGR03520 411154009140 Domain of unknown function DUF21; Region: DUF21; pfam01595 411154009141 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 411154009142 Transporter associated domain; Region: CorC_HlyC; smart01091 411154009143 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 411154009144 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154009145 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 411154009146 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 411154009147 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154009148 starch binding outer membrane protein SusD; Region: SusD; cd08977 411154009149 EamA-like transporter family; Region: EamA; pfam00892 411154009150 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 411154009151 EamA-like transporter family; Region: EamA; pfam00892 411154009152 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 411154009153 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 411154009154 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 411154009155 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 411154009156 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 411154009157 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 411154009158 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 411154009159 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 411154009160 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 411154009161 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 411154009162 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 411154009163 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 411154009164 Uncharacterized conserved protein [Function unknown]; Region: COG5276 411154009165 Uncharacterized conserved protein [Function unknown]; Region: COG5276 411154009166 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 411154009167 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 411154009168 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 411154009169 FeS/SAM binding site; other site 411154009170 TRAM domain; Region: TRAM; pfam01938 411154009171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 411154009172 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 411154009173 Walker A motif; other site 411154009174 ATP binding site [chemical binding]; other site 411154009175 Walker B motif; other site 411154009176 arginine finger; other site 411154009177 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 411154009178 Lipopolysaccharide-assembly; Region: LptE; pfam04390 411154009179 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 411154009180 oligomerisation interface [polypeptide binding]; other site 411154009181 mobile loop; other site 411154009182 roof hairpin; other site 411154009183 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 411154009184 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 411154009185 ring oligomerisation interface [polypeptide binding]; other site 411154009186 ATP/Mg binding site [chemical binding]; other site 411154009187 stacking interactions; other site 411154009188 hinge regions; other site 411154009189 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 411154009190 putative hydrophobic ligand binding site [chemical binding]; other site 411154009191 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 411154009192 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 411154009193 transmembrane helices; other site 411154009194 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 411154009195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 411154009196 alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169 411154009197 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 411154009198 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 411154009199 FeS/SAM binding site; other site 411154009200 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 411154009201 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; pfam09837 411154009202 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 411154009203 Cna protein B-type domain; Region: Cna_B_2; pfam13715 411154009204 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 411154009205 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 411154009206 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 411154009207 starch binding outer membrane protein SusD; Region: SusD; cl17845 411154009208 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 411154009209 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 411154009210 active site 411154009211 metal binding site [ion binding]; metal-binding site 411154009212 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 411154009213 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 411154009214 active site residue [active] 411154009215 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 411154009216 purine nucleoside phosphorylase; Provisional; Region: PRK08202 411154009217 Methyltransferase domain; Region: Methyltransf_31; pfam13847 411154009218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 411154009219 S-adenosylmethionine binding site [chemical binding]; other site 411154009220 Protein of unknown function, DUF547; Region: DUF547; pfam04784 411154009221 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 411154009222 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 411154009223 Probable Catalytic site; other site 411154009224 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 411154009225 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 411154009226 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 411154009227 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 411154009228 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 411154009229 4Fe-4S binding domain; Region: Fer4_5; pfam12801 411154009230 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 411154009231 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 411154009232 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 411154009233 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 411154009234 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 411154009235 Ligand binding site; other site 411154009236 Putative Catalytic site; other site 411154009237 DXD motif; other site 411154009238 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 411154009239 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 411154009240 DXD motif; other site 411154009241 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 411154009242 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 411154009243 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 411154009244 deoxyhypusine synthase; Region: dhys; TIGR00321 411154009245 Deoxyhypusine synthase; Region: DS; cl00826 411154009246 Deoxyhypusine synthase; Region: DS; cl00826 411154009247 agmatinase; Region: agmatinase; TIGR01230 411154009248 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 411154009249 putative active site [active] 411154009250 Mn binding site [ion binding]; other site 411154009251 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 411154009252 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 411154009253 dimer interface [polypeptide binding]; other site 411154009254 active site 411154009255 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 411154009256 catalytic residues [active] 411154009257 substrate binding site [chemical binding]; other site 411154009258 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 411154009259 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 411154009260 RNA binding surface [nucleotide binding]; other site 411154009261 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 411154009262 active site 411154009263 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 411154009264 UbiA prenyltransferase family; Region: UbiA; pfam01040 411154009265 mevalonate kinase; Region: mevalon_kin; TIGR00549 411154009266 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 411154009267 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 411154009268 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 411154009269 diphosphomevalonate decarboxylase; Region: PLN02407 411154009270 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 411154009271 TspO/MBR family; Region: TspO_MBR; pfam03073 411154009272 flavoprotein, HI0933 family; Region: TIGR00275 411154009273 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 411154009274 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 411154009275 active site 411154009276 catalytic site [active] 411154009277 short chain dehydrogenase; Provisional; Region: PRK06701 411154009278 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 411154009279 NAD binding site [chemical binding]; other site 411154009280 metal binding site [ion binding]; metal-binding site 411154009281 active site 411154009282 Predicted membrane protein [Function unknown]; Region: COG2323