-- dump date   	20140619_103348
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
634177000001	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
634177000002	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634177000003	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634177000004	catalytic residues [active]
634177000005	catalytic nucleophile [active]
634177000006	Presynaptic Site I dimer interface [polypeptide binding]; other site
634177000007	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634177000008	Synaptic Flat tetramer interface [polypeptide binding]; other site
634177000009	Synaptic Site I dimer interface [polypeptide binding]; other site
634177000010	DNA binding site [nucleotide binding]
634177000011	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393
634177000012	DNA-binding interface [nucleotide binding]; DNA binding site
634177000013	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634177000014	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634177000015	catalytic residue [active]
634177000016	TrbC/VIRB2 family; Region: TrbC; cl01583
634177000017	type IV secretion system protein VirB4; Provisional; Region: PRK13853
634177000018	Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cl00053
634177000019	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
634177000020	AAA domain; Region: AAA_23; pfam13476
634177000021	Domain of unknown function DUF87; Region: DUF87; cl19135
634177000022	Walker A/P-loop; other site
634177000023	ATP binding site [chemical binding]; other site
634177000024	type IV secretion system protein VirB5; Provisional; Region: PRK13860
634177000025	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
634177000026	VirB8 protein; Region: VirB8; cl01500
634177000027	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
634177000028	VirB7 interaction site; other site
634177000029	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
634177000030	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
634177000031	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
634177000032	Walker A motif; other site
634177000033	ATP binding site [chemical binding]; other site
634177000034	Walker B motif; other site
634177000035	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
634177000036	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
634177000037	Walker A motif; other site
634177000038	ATP binding site [chemical binding]; other site
634177000039	Walker B motif; other site
634177000040	T5orf172 domain; Region: T5orf172; pfam10544
634177000041	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
634177000042	dimerization interface [polypeptide binding]; other site
634177000043	putative DNA binding site [nucleotide binding]; other site
634177000044	putative Zn2+ binding site [ion binding]; other site
634177000045	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
634177000046	catalytic residues [active]
634177000047	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
634177000048	transmembrane helices; other site
634177000049	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
634177000050	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
634177000051	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
634177000052	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634177000053	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
634177000054	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
634177000055	Transposase; Region: DEDD_Tnp_IS110; pfam01548
634177000056	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
634177000057	Winged helix-turn helix; Region: HTH_29; pfam13551
634177000058	Integrase core domain; Region: rve; pfam00665
634177000059	Integrase core domain; Region: rve_3; pfam13683
634177000060	Transposase; Region: HTH_Tnp_1; pfam01527
634177000061	HTH-like domain; Region: HTH_21; pfam13276
634177000062	Integrase core domain; Region: rve; pfam00665
634177000063	Integrase core domain; Region: rve_3; pfam13683
634177000064	Transposase; Region: HTH_Tnp_1; cl17663
634177000065	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634177000066	HTH-like domain; Region: HTH_21; pfam13276
634177000067	Integrase core domain; Region: rve; pfam00665
634177000068	Integrase core domain; Region: rve_3; pfam13683
634177000069	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
634177000070	transposase/IS protein; Provisional; Region: PRK09183
634177000071	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177000072	Walker A motif; other site
634177000073	ATP binding site [chemical binding]; other site
634177000074	Walker B motif; other site
634177000075	arginine finger; other site
634177000076	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
634177000077	Transposase; Region: DEDD_Tnp_IS110; pfam01548
634177000078	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
634177000079	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634177000080	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634177000081	Winged helix-turn helix; Region: HTH_29; pfam13551
634177000082	Integrase core domain; Region: rve; pfam00665
634177000083	Integrase core domain; Region: rve_3; pfam13683
634177000084	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634177000085	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
634177000086	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
634177000087	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
634177000088	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
634177000089	K+-transporting ATPase, c chain; Region: KdpC; cl00944
634177000090	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
634177000091	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
634177000092	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
634177000093	Ligand Binding Site [chemical binding]; other site
634177000094	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
634177000095	GAF domain; Region: GAF_3; pfam13492
634177000096	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634177000097	dimer interface [polypeptide binding]; other site
634177000098	phosphorylation site [posttranslational modification]
634177000099	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177000100	ATP binding site [chemical binding]; other site
634177000101	Mg2+ binding site [ion binding]; other site
634177000102	G-X-G motif; other site
634177000103	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634177000104	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177000105	active site
634177000106	phosphorylation site [posttranslational modification]
634177000107	intermolecular recognition site; other site
634177000108	dimerization interface [polypeptide binding]; other site
634177000109	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634177000110	DNA binding site [nucleotide binding]
634177000111	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634177000112	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634177000113	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634177000114	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634177000115	catalytic residues [active]
634177000116	catalytic nucleophile [active]
634177000117	Presynaptic Site I dimer interface [polypeptide binding]; other site
634177000118	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634177000119	Synaptic Flat tetramer interface [polypeptide binding]; other site
634177000120	Synaptic Site I dimer interface [polypeptide binding]; other site
634177000121	DNA binding site [nucleotide binding]
634177000122	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393
634177000123	DNA-binding interface [nucleotide binding]; DNA binding site
634177000124	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
634177000125	TrwC relaxase; Region: TrwC; cl19905
634177000126	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
634177000127	AAA domain; Region: AAA_30; pfam13604
634177000128	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951
634177000129	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
634177000130	Fic/DOC family; Region: Fic; cl00960
634177000131	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634177000132	Transposase; Region: HTH_Tnp_1; cl17663
634177000133	putative transposase OrfB; Reviewed; Region: PHA02517
634177000134	HTH-like domain; Region: HTH_21; pfam13276
634177000135	Integrase core domain; Region: rve; pfam00665
634177000136	Integrase core domain; Region: rve_3; pfam13683
634177000137	Fic/DOC family; Region: Fic; cl00960
634177000138	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
634177000139	FIC domain binding interface [polypeptide binding]; other site
634177000140	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
634177000141	dimer interface [polypeptide binding]; other site
634177000142	ssDNA binding site [nucleotide binding]; other site
634177000143	tetramer (dimer of dimers) interface [polypeptide binding]; other site
634177000144	Zinc ribbon domain; Region: Zn-ribbon_8; pfam09723
634177000145	Domain of unknown function (DUF932); Region: DUF932; cl12129
634177000146	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
634177000147	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
634177000148	ParB-like nuclease domain; Region: ParB; smart00470
634177000149	Abi-like protein; Region: Abi_2; cl01988
634177000150	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
634177000151	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
634177000152	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634177000153	sequence-specific DNA binding site [nucleotide binding]; other site
634177000154	salt bridge; other site
634177000155	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
634177000156	Walker A motif; other site
634177000157	ATP binding site [chemical binding]; other site
634177000158	Walker B motif; other site
634177000159	Replication initiator protein A; Region: RPA; cl19398
634177000160	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04537
634177000161	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
634177000162	DnaA N-terminal domain; Region: DnaA_N; pfam11638
634177000163	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177000164	Walker A motif; other site
634177000165	ATP binding site [chemical binding]; other site
634177000166	Walker B motif; other site
634177000167	arginine finger; other site
634177000168	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
634177000169	DnaA box-binding interface [nucleotide binding]; other site
634177000170	DNA polymerase III subunit beta; Validated; Region: PRK05643
634177000171	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
634177000172	putative DNA binding surface [nucleotide binding]; other site
634177000173	dimer interface [polypeptide binding]; other site
634177000174	beta-clamp/clamp loader binding surface; other site
634177000175	beta-clamp/translesion DNA polymerase binding surface; other site
634177000176	recombination protein F; Reviewed; Region: recF; PRK00064
634177000177	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177000178	Walker A/P-loop; other site
634177000179	ATP binding site [chemical binding]; other site
634177000180	Q-loop/lid; other site
634177000181	ABC transporter signature motif; other site
634177000182	Walker B; other site
634177000183	D-loop; other site
634177000184	H-loop/switch region; other site
634177000185	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
634177000186	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177000187	ATP binding site [chemical binding]; other site
634177000188	Mg2+ binding site [ion binding]; other site
634177000189	G-X-G motif; other site
634177000190	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
634177000191	anchoring element; other site
634177000192	dimer interface [polypeptide binding]; other site
634177000193	ATP binding site [chemical binding]; other site
634177000194	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
634177000195	active site
634177000196	putative metal-binding site [ion binding]; other site
634177000197	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
634177000198	phosphoglycolate phosphatase; Provisional; Region: PRK13222
634177000199	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634177000200	motif II; other site
634177000201	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
634177000202	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
634177000203	Substrate binding site; other site
634177000204	Mg++ binding site; other site
634177000205	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
634177000206	active site
634177000207	substrate binding site [chemical binding]; other site
634177000208	CoA binding site [chemical binding]; other site
634177000209	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
634177000210	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
634177000211	glutaminase active site [active]
634177000212	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
634177000213	dimer interface [polypeptide binding]; other site
634177000214	active site
634177000215	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
634177000216	dimer interface [polypeptide binding]; other site
634177000217	active site
634177000218	FAD dependent oxidoreductase; Region: DAO; pfam01266
634177000219	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177000220	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177000221	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
634177000222	thiS-thiF/thiG interaction site; other site
634177000223	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
634177000224	ThiS interaction site; other site
634177000225	putative active site [active]
634177000226	tetramer interface [polypeptide binding]; other site
634177000227	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
634177000228	thiamine phosphate binding site [chemical binding]; other site
634177000229	active site
634177000230	pyrophosphate binding site [ion binding]; other site
634177000231	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634177000232	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
634177000233	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
634177000234	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
634177000235	ligand binding site [chemical binding]; other site
634177000236	flexible hinge region; other site
634177000237	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
634177000238	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cd00176
634177000239	linker region; other site
634177000240	diaminopimelate decarboxylase; Region: lysA; TIGR01048
634177000241	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
634177000242	active site
634177000243	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
634177000244	substrate binding site [chemical binding]; other site
634177000245	catalytic residues [active]
634177000246	dimer interface [polypeptide binding]; other site
634177000247	Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295
634177000248	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
634177000249	active site
634177000250	catalytic motif [active]
634177000251	Zn binding site [ion binding]; other site
634177000252	argininosuccinate lyase; Provisional; Region: PRK00855
634177000253	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
634177000254	active sites [active]
634177000255	tetramer interface [polypeptide binding]; other site
634177000256	N-formylglutamate amidohydrolase; Region: FGase; cl01522
634177000257	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
634177000258	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
634177000259	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
634177000260	shikimate binding site; other site
634177000261	NAD(P) binding site [chemical binding]; other site
634177000262	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
634177000263	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
634177000264	CoA-binding site [chemical binding]; other site
634177000265	ATP-binding [chemical binding]; other site
634177000266	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
634177000267	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
634177000268	active site
634177000269	catalytic site [active]
634177000270	substrate binding site [chemical binding]; other site
634177000271	Cache domain; Region: Cache_1; pfam02743
634177000272	GAF domain; Region: GAF; pfam01590
634177000273	cyclase homology domain; Region: CHD; cd07302
634177000274	nucleotidyl binding site; other site
634177000275	metal binding site [ion binding]; metal-binding site
634177000276	dimer interface [polypeptide binding]; other site
634177000277	Permease; Region: Permease; pfam02405
634177000278	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177000279	Q-loop/lid; other site
634177000280	ABC transporter signature motif; other site
634177000281	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
634177000282	mce related protein; Region: MCE; pfam02470
634177000283	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
634177000284	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
634177000285	Sulfate transporter family; Region: Sulfate_transp; pfam00916
634177000286	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
634177000287	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
634177000288	active site
634177000289	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
634177000290	Ligand Binding Site [chemical binding]; other site
634177000291	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
634177000292	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634177000293	FeS/SAM binding site; other site
634177000294	biotin synthase; Provisional; Region: PRK15108
634177000295	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634177000296	FeS/SAM binding site; other site
634177000297	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
634177000298	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
634177000299	CoA binding domain; Region: CoA_binding; pfam02629
634177000300	CoA-ligase; Region: Ligase_CoA; pfam00549
634177000301	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
634177000302	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
634177000303	CoA-ligase; Region: Ligase_CoA; pfam00549
634177000304	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
634177000305	dinuclear metal binding motif [ion binding]; other site
634177000306	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
634177000307	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
634177000308	Methyltransferase domain; Region: Methyltransf_31; pfam13847
634177000309	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177000310	S-adenosylmethionine binding site [chemical binding]; other site
634177000311	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
634177000312	putative active site [active]
634177000313	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
634177000314	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
634177000315	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
634177000316	NAD(P) binding site [chemical binding]; other site
634177000317	homotetramer interface [polypeptide binding]; other site
634177000318	homodimer interface [polypeptide binding]; other site
634177000319	active site
634177000320	acyl carrier protein; Provisional; Region: acpP; PRK00982
634177000321	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
634177000322	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
634177000323	dimer interface [polypeptide binding]; other site
634177000324	active site
634177000325	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
634177000326	dimerization interface [polypeptide binding]; other site
634177000327	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
634177000328	putative amphipathic alpha helix; other site
634177000329	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
634177000330	active site
634177000331	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
634177000332	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
634177000333	active site
634177000334	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
634177000335	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
634177000336	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
634177000337	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
634177000338	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
634177000339	active site
634177000340	metal binding site [ion binding]; metal-binding site
634177000341	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
634177000342	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
634177000343	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
634177000344	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634177000345	catalytic residue [active]
634177000346	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
634177000347	acyl-CoA synthetase; Validated; Region: PRK09192
634177000348	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
634177000349	acyl-activating enzyme (AAE) consensus motif; other site
634177000350	active site
634177000351	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; cl19502
634177000352	Transposase domain (DUF772); Region: DUF772; pfam05598
634177000353	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177000354	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177000355	Protein of unknown function DUF262; Region: DUF262; pfam03235
634177000356	Protein of unknown function DUF262; Region: DUF262; pfam03235
634177000357	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
634177000358	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177000359	Transposase domain (DUF772); Region: DUF772; pfam05598
634177000360	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177000361	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177000362	putative transposase OrfB; Reviewed; Region: PHA02517
634177000363	Integrase core domain; Region: rve; pfam00665
634177000364	Integrase core domain; Region: rve_3; cl15866
634177000365	Helix-turn-helix domain; Region: HTH_28; pfam13518
634177000366	Winged helix-turn helix; Region: HTH_29; pfam13551
634177000367	Homeodomain-like domain; Region: HTH_32; pfam13565
634177000368	DDE superfamily endonuclease; Region: DDE_3; cl19249
634177000369	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
634177000370	hypothetical protein; Provisional; Region: PRK08201
634177000371	metal binding site [ion binding]; metal-binding site
634177000372	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
634177000373	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634177000374	NAD(P) binding site [chemical binding]; other site
634177000375	catalytic residues [active]
634177000376	Protein of unknown function (DUF3100); Region: DUF3100; pfam11299
634177000377	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
634177000378	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
634177000379	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
634177000380	trimer interface [polypeptide binding]; other site
634177000381	active site
634177000382	substrate binding site [chemical binding]; other site
634177000383	CoA binding site [chemical binding]; other site
634177000384	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
634177000385	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
634177000386	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
634177000387	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177000388	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177000389	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
634177000390	dimerization interface [polypeptide binding]; other site
634177000391	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
634177000392	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
634177000393	putative metal binding site [ion binding]; other site
634177000394	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
634177000395	Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546
634177000396	metal binding site [ion binding]; metal-binding site
634177000397	dimer interface [polypeptide binding]; other site
634177000398	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
634177000399	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
634177000400	putative DNA binding site [nucleotide binding]; other site
634177000401	putative Zn2+ binding site [ion binding]; other site
634177000402	AsnC family; Region: AsnC_trans_reg; pfam01037
634177000403	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177000404	metabolite-proton symporter; Region: 2A0106; TIGR00883
634177000405	putative substrate translocation pore; other site
634177000406	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
634177000407	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
634177000408	metal binding site [ion binding]; metal-binding site
634177000409	putative dimer interface [polypeptide binding]; other site
634177000410	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
634177000411	GntP family permease; Region: GntP_permease; pfam02447
634177000412	Uncharacterized conserved protein [Function unknown]; Region: COG5476
634177000413	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
634177000414	MlrC C-terminus; Region: MlrC_C; pfam07171
634177000415	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
634177000416	homotrimer interaction site [polypeptide binding]; other site
634177000417	putative active site [active]
634177000418	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
634177000419	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820
634177000420	dimer interface [polypeptide binding]; other site
634177000421	active site
634177000422	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
634177000423	substrate binding site [chemical binding]; other site
634177000424	catalytic residue [active]
634177000425	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177000426	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177000427	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
634177000428	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
634177000429	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177000430	catalytic residue [active]
634177000431	AsnC family; Region: AsnC_trans_reg; pfam01037
634177000432	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
634177000433	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
634177000434	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
634177000435	putative Zn2+ binding site [ion binding]; other site
634177000436	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
634177000437	EamA-like transporter family; Region: EamA; pfam00892
634177000438	Uncharacterized conserved protein [Function unknown]; Region: COG5476
634177000439	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
634177000440	MlrC C-terminus; Region: MlrC_C; pfam07171
634177000441	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
634177000442	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
634177000443	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
634177000444	D-glutamate deacylase; Validated; Region: PRK09061
634177000445	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634177000446	active site
634177000447	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
634177000448	putative active site [active]
634177000449	putative metal binding site [ion binding]; other site
634177000450	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
634177000451	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634177000452	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
634177000453	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177000454	putative substrate translocation pore; other site
634177000455	Integrase core domain; Region: rve; pfam00665
634177000456	Integrase core domain; Region: rve_3; pfam13683
634177000457	Transposase; Region: DEDD_Tnp_IS110; pfam01548
634177000458	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
634177000459	Putative pyruvate format-lyase activating enzyme (DUF1786); Region: DUF1786; cl01638
634177000460	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
634177000461	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
634177000462	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
634177000463	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
634177000464	putative active site [active]
634177000465	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
634177000466	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634177000467	catalytic residue [active]
634177000468	allantoate amidohydrolase; Reviewed; Region: PRK12893
634177000469	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
634177000470	active site
634177000471	metal binding site [ion binding]; metal-binding site
634177000472	dimer interface [polypeptide binding]; other site
634177000473	N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569
634177000474	tetramer interface [polypeptide binding]; other site
634177000475	active site
634177000476	catalytic triad [active]
634177000477	dimer interface [polypeptide binding]; other site
634177000478	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951
634177000479	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
634177000480	FAD dependent oxidoreductase; Region: DAO; pfam01266
634177000481	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177000482	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177000483	D-galactonate transporter; Region: 2A0114; TIGR00893
634177000484	putative substrate translocation pore; other site
634177000485	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634177000486	Transposase; Region: HTH_Tnp_1; cl17663
634177000487	DDE superfamily endonuclease; Region: DDE_3; cl19249
634177000488	Transposase, Mutator family; Region: Transposase_mut; pfam00872
634177000489	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
634177000490	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
634177000491	Transposase; Region: DEDD_Tnp_IS110; pfam01548
634177000492	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
634177000493	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634177000494	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634177000495	non-specific DNA binding site [nucleotide binding]; other site
634177000496	salt bridge; other site
634177000497	sequence-specific DNA binding site [nucleotide binding]; other site
634177000498	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
634177000499	Domain of unknown function (DUF955); Region: DUF955; pfam06114
634177000500	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
634177000501	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
634177000502	acyl-activating enzyme (AAE) consensus motif; other site
634177000503	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
634177000504	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
634177000505	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
634177000506	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177000507	metabolite-proton symporter; Region: 2A0106; TIGR00883
634177000508	putative substrate translocation pore; other site
634177000509	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
634177000510	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
634177000511	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
634177000512	putative ligand binding site [chemical binding]; other site
634177000513	NAD binding site [chemical binding]; other site
634177000514	catalytic site [active]
634177000515	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634177000516	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177000517	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177000518	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177000519	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177000520	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177000521	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177000522	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177000523	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
634177000524	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
634177000525	heme-binding site [chemical binding]; other site
634177000526	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
634177000527	FAD binding pocket [chemical binding]; other site
634177000528	FAD binding motif [chemical binding]; other site
634177000529	phosphate binding motif [ion binding]; other site
634177000530	beta-alpha-beta structure motif; other site
634177000531	NAD binding pocket [chemical binding]; other site
634177000532	Heme binding  pocket [chemical binding]; other site
634177000533	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177000534	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177000535	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634177000536	Protein of unknown function, DUF488; Region: DUF488; pfam04343
634177000537	potential frameshift: common BLAST hit: gi|16263195|ref|NP_435988.1| TRm3 transposase
634177000538	Transposase, Mutator family; Region: Transposase_mut; cl19537
634177000539	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
634177000540	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
634177000541	Transposase, Mutator family; Region: Transposase_mut; cl19537
634177000542	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177000543	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177000544	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
634177000545	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
634177000546	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
634177000547	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655
634177000548	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
634177000549	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
634177000550	putative molybdopterin cofactor binding site [chemical binding]; other site
634177000551	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
634177000552	putative molybdopterin cofactor binding site; other site
634177000553	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
634177000554	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634177000555	FeS/SAM binding site; other site
634177000556	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
634177000557	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
634177000558	GTP binding site; other site
634177000559	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399
634177000560	MoaE homodimer interface [polypeptide binding]; other site
634177000561	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
634177000562	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177000563	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177000564	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
634177000565	dimerization interface [polypeptide binding]; other site
634177000566	DDE superfamily endonuclease; Region: DDE_3; cl19249
634177000567	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151
634177000568	homotrimer interaction site [polypeptide binding]; other site
634177000569	putative active site [active]
634177000570	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634177000571	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
634177000572	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
634177000573	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
634177000574	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
634177000575	NAD binding site [chemical binding]; other site
634177000576	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177000577	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634177000578	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634177000579	N-terminal plug; other site
634177000580	ligand-binding site [chemical binding]; other site
634177000581	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634177000582	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177000583	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634177000584	Transposase; Region: HTH_Tnp_1; cl17663
634177000585	Integrase core domain; Region: rve; pfam00665
634177000586	glycogen synthase; Provisional; Region: PRK14099
634177000587	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
634177000588	ADP-binding pocket [chemical binding]; other site
634177000589	homodimer interface [polypeptide binding]; other site
634177000590	glycogen branching enzyme; Provisional; Region: PRK05402
634177000591	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
634177000592	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
634177000593	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
634177000594	active site
634177000595	catalytic site [active]
634177000596	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
634177000597	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
634177000598	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
634177000599	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
634177000600	active site
634177000601	catalytic site [active]
634177000602	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
634177000603	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
634177000604	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
634177000605	catalytic site [active]
634177000606	active site
634177000607	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
634177000608	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
634177000609	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
634177000610	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
634177000611	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
634177000612	active site
634177000613	catalytic site [active]
634177000614	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
634177000615	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
634177000616	Mechanosensitive ion channel; Region: MS_channel; pfam00924
634177000617	manganese transport protein MntH; Reviewed; Region: PRK00701
634177000618	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
634177000619	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
634177000620	Domain of unknown function DUF21; Region: DUF21; pfam01595
634177000621	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
634177000622	Transporter associated domain; Region: CorC_HlyC; smart01091
634177000623	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
634177000624	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177000625	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
634177000626	dimerization interface [polypeptide binding]; other site
634177000627	peroxiredoxin; Region: AhpC; TIGR03137
634177000628	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
634177000629	dimer interface [polypeptide binding]; other site
634177000630	decamer (pentamer of dimers) interface [polypeptide binding]; other site
634177000631	catalytic triad [active]
634177000632	peroxidatic and resolving cysteines [active]
634177000633	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
634177000634	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
634177000635	catalytic residue [active]
634177000636	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
634177000637	catalytic residues [active]
634177000638	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177000639	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634177000640	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
634177000641	NAD(P) binding site [chemical binding]; other site
634177000642	catalytic residues [active]
634177000643	Putative glucoamylase; Region: Glycoamylase; cl19893
634177000644	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
634177000645	putative active site [active]
634177000646	metal binding site [ion binding]; metal-binding site
634177000647	Phosphate-selective porin O and P; Region: Porin_O_P; cl19535
634177000648	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
634177000649	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634177000650	active site
634177000651	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634177000652	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
634177000653	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
634177000654	potential frameshift: common BLAST hit: gi|209542495|ref|YP_002274724.1| transposase IS630
634177000655	Pyruvate kinase, barrel domain; Region: PK; cl17342
634177000656	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
634177000657	LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541
634177000658	Autoinducer binding domain; Region: Autoind_bind; pfam03472
634177000659	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
634177000660	DNA binding residues [nucleotide binding]
634177000661	dimerization interface [polypeptide binding]; other site
634177000662	CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934
634177000663	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634177000664	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634177000665	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634177000666	Transposase; Region: HTH_Tnp_1; pfam01527
634177000667	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634177000668	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634177000669	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634177000670	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634177000671	zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005
634177000672	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634177000673	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634177000674	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
634177000675	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
634177000676	Outer membrane efflux protein; Region: OEP; pfam02321
634177000677	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
634177000678	HlyD family secretion protein; Region: HlyD_3; pfam13437
634177000679	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
634177000680	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634177000681	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177000682	active site
634177000683	phosphorylation site [posttranslational modification]
634177000684	intermolecular recognition site; other site
634177000685	dimerization interface [polypeptide binding]; other site
634177000686	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634177000687	DNA binding site [nucleotide binding]
634177000688	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634177000689	HAMP domain; Region: HAMP; pfam00672
634177000690	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634177000691	dimer interface [polypeptide binding]; other site
634177000692	phosphorylation site [posttranslational modification]
634177000693	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177000694	ATP binding site [chemical binding]; other site
634177000695	Mg2+ binding site [ion binding]; other site
634177000696	G-X-G motif; other site
634177000697	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
634177000698	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
634177000699	Transposase domain (DUF772); Region: DUF772; pfam05598
634177000700	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177000701	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177000702	Heme NO binding; Region: HNOB; pfam07700
634177000703	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177000704	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177000705	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
634177000706	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
634177000707	putative symporter YagG; Provisional; Region: PRK09669; cl15392
634177000708	MFS/sugar transport protein; Region: MFS_2; pfam13347
634177000709	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
634177000710	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177000711	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
634177000712	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
634177000713	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
634177000714	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
634177000715	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
634177000716	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
634177000717	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
634177000718	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
634177000719	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
634177000720	Transcriptional regulators [Transcription]; Region: PurR; COG1609
634177000721	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
634177000722	DNA binding site [nucleotide binding]
634177000723	domain linker motif; other site
634177000724	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
634177000725	FkbH-like domain; Region: FkbH; TIGR01686
634177000726	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634177000727	active site
634177000728	motif I; other site
634177000729	motif II; other site
634177000730	Protein of unknown function (DUF563); Region: DUF563; pfam04577
634177000731	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634177000732	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177000733	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634177000734	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634177000735	zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005
634177000736	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634177000737	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634177000738	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634177000739	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634177000740	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634177000741	Transposase; Region: HTH_Tnp_1; pfam01527
634177000742	Transposase domain (DUF772); Region: DUF772; pfam05598
634177000743	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177000744	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
634177000745	amphipathic channel; other site
634177000746	Asn-Pro-Ala signature motifs; other site
634177000747	glycerol kinase; Provisional; Region: glpK; PRK00047
634177000748	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
634177000749	nucleotide binding site [chemical binding]; other site
634177000750	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634177000751	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
634177000752	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177000753	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177000754	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
634177000755	putative effector binding pocket; other site
634177000756	dimerization interface [polypeptide binding]; other site
634177000757	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
634177000758	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
634177000759	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
634177000760	EamA-like transporter family; Region: EamA; pfam00892
634177000761	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
634177000762	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634177000763	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
634177000764	PLD-like domain; Region: PLDc_2; pfam13091
634177000765	putative active site [active]
634177000766	catalytic site [active]
634177000767	Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107
634177000768	PLD-like domain; Region: PLDc_2; pfam13091
634177000769	putative active site [active]
634177000770	putative catalytic site [active]
634177000771	Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804
634177000772	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
634177000773	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177000774	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177000775	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
634177000776	catalytic residue [active]
634177000777	murein transglycosylase A; Provisional; Region: mltA; PRK11162
634177000778	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
634177000779	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
634177000780	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
634177000781	putative active site [active]
634177000782	putative substrate binding site [chemical binding]; other site
634177000783	putative cosubstrate binding site; other site
634177000784	catalytic site [active]
634177000785	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
634177000786	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
634177000787	Transposase domain (DUF772); Region: DUF772; pfam05598
634177000788	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177000789	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177000790	Putative lysophospholipase; Region: Hydrolase_4; cl19140
634177000791	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
634177000792	thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840
634177000793	Sulfatase; Region: Sulfatase; cl19157
634177000794	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177000795	Transposase, Mutator family; Region: Transposase_mut; pfam00872
634177000796	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
634177000797	Transposase domain (DUF772); Region: DUF772; pfam05598
634177000798	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177000799	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
634177000800	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634177000801	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634177000802	Flavin Reductases; Region: FlaRed; cl00801
634177000803	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
634177000804	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177000805	putative substrate translocation pore; other site
634177000806	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
634177000807	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
634177000808	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
634177000809	active site
634177000810	dimer interface [polypeptide binding]; other site
634177000811	non-prolyl cis peptide bond; other site
634177000812	insertion regions; other site
634177000813	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
634177000814	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
634177000815	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
634177000816	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
634177000817	active site
634177000818	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932
634177000819	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
634177000820	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
634177000821	active site
634177000822	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177000823	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177000824	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177000825	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177000826	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
634177000827	Serine hydrolase; Region: Ser_hydrolase; cl17834
634177000828	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
634177000829	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634177000830	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
634177000831	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879
634177000832	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
634177000833	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634177000834	Putative glucoamylase; Region: Glycoamylase; pfam10091
634177000835	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
634177000836	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
634177000837	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951
634177000838	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
634177000839	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634177000840	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
634177000841	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177000842	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177000843	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
634177000844	putative effector binding pocket; other site
634177000845	putative dimerization interface [polypeptide binding]; other site
634177000846	short chain dehydrogenase; Provisional; Region: PRK12744
634177000847	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177000848	NAD(P) binding site [chemical binding]; other site
634177000849	active site
634177000850	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
634177000851	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177000852	Walker A/P-loop; other site
634177000853	ATP binding site [chemical binding]; other site
634177000854	Q-loop/lid; other site
634177000855	ABC transporter signature motif; other site
634177000856	Walker B; other site
634177000857	D-loop; other site
634177000858	H-loop/switch region; other site
634177000859	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
634177000860	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
634177000861	DNA binding residues [nucleotide binding]
634177000862	dimerization interface [polypeptide binding]; other site
634177000863	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
634177000864	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
634177000865	active site residue [active]
634177000866	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
634177000867	catalytic residues [active]
634177000868	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
634177000869	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
634177000870	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
634177000871	quinolinate synthetase; Provisional; Region: PRK09375
634177000872	L-aspartate oxidase; Provisional; Region: PRK07512
634177000873	L-aspartate oxidase; Provisional; Region: PRK06175
634177000874	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
634177000875	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
634177000876	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
634177000877	dimerization interface [polypeptide binding]; other site
634177000878	active site
634177000879	AAA domain; Region: AAA_23; pfam13476
634177000880	AAA domain; Region: AAA_27; pfam13514
634177000881	Walker A/P-loop; other site
634177000882	ATP binding site [chemical binding]; other site
634177000883	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
634177000884	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
634177000885	active site
634177000886	metal binding site [ion binding]; metal-binding site
634177000887	DNA binding site [nucleotide binding]
634177000888	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
634177000889	tetramerization interface [polypeptide binding]; other site
634177000890	NAD(P) binding site [chemical binding]; other site
634177000891	catalytic residues [active]
634177000892	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177000893	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
634177000894	dimerization interface [polypeptide binding]; other site
634177000895	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
634177000896	DNA-binding site [nucleotide binding]; DNA binding site
634177000897	RNA-binding motif; other site
634177000898	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
634177000899	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
634177000900	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634177000901	N-terminal plug; other site
634177000902	ligand-binding site [chemical binding]; other site
634177000903	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634177000904	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
634177000905	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634177000906	dimer interface [polypeptide binding]; other site
634177000907	phosphorylation site [posttranslational modification]
634177000908	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177000909	ATP binding site [chemical binding]; other site
634177000910	Mg2+ binding site [ion binding]; other site
634177000911	G-X-G motif; other site
634177000912	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
634177000913	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
634177000914	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
634177000915	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177000916	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177000917	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
634177000918	putative substrate binding pocket [chemical binding]; other site
634177000919	putative dimerization interface [polypeptide binding]; other site
634177000920	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
634177000921	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126
634177000922	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177000923	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
634177000924	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
634177000925	active site
634177000926	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
634177000927	dimer interface [polypeptide binding]; other site
634177000928	substrate binding site [chemical binding]; other site
634177000929	catalytic residues [active]
634177000930	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
634177000931	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
634177000932	putative DNA binding site [nucleotide binding]; other site
634177000933	putative Zn2+ binding site [ion binding]; other site
634177000934	AsnC family; Region: AsnC_trans_reg; pfam01037
634177000935	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
634177000936	amphipathic channel; other site
634177000937	Asn-Pro-Ala signature motifs; other site
634177000938	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
634177000939	FAD dependent oxidoreductase; Region: DAO; pfam01266
634177000940	glycerol kinase; Provisional; Region: glpK; PRK00047
634177000941	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
634177000942	N- and C-terminal domain interface [polypeptide binding]; other site
634177000943	active site
634177000944	MgATP binding site [chemical binding]; other site
634177000945	catalytic site [active]
634177000946	metal binding site [ion binding]; metal-binding site
634177000947	glycerol binding site [chemical binding]; other site
634177000948	homotetramer interface [polypeptide binding]; other site
634177000949	homodimer interface [polypeptide binding]; other site
634177000950	FBP binding site [chemical binding]; other site
634177000951	protein IIAGlc interface [polypeptide binding]; other site
634177000952	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
634177000953	putative active site [active]
634177000954	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
634177000955	active site
634177000956	intersubunit interface [polypeptide binding]; other site
634177000957	zinc binding site [ion binding]; other site
634177000958	Na+ binding site [ion binding]; other site
634177000959	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
634177000960	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
634177000961	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
634177000962	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
634177000963	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177000964	NAD(P) binding site [chemical binding]; other site
634177000965	active site
634177000966	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
634177000967	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177000968	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634177000969	Predicted transcriptional regulator [Transcription]; Region: COG1959
634177000970	Rrf2 family protein; Region: rrf2_super; TIGR00738
634177000971	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
634177000972	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177000973	Walker A/P-loop; other site
634177000974	ATP binding site [chemical binding]; other site
634177000975	Q-loop/lid; other site
634177000976	ABC transporter signature motif; other site
634177000977	Walker B; other site
634177000978	D-loop; other site
634177000979	H-loop/switch region; other site
634177000980	sulfate transport protein; Provisional; Region: cysT; CHL00187
634177000981	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634177000982	dimer interface [polypeptide binding]; other site
634177000983	conserved gate region; other site
634177000984	putative PBP binding loops; other site
634177000985	ABC-ATPase subunit interface; other site
634177000986	sulfate transport protein; Provisional; Region: cysT; CHL00187
634177000987	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634177000988	dimer interface [polypeptide binding]; other site
634177000989	conserved gate region; other site
634177000990	putative PBP binding loops; other site
634177000991	ABC-ATPase subunit interface; other site
634177000992	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
634177000993	Alginate export; Region: Alginate_exp; pfam13372
634177000994	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634177000995	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634177000996	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
634177000997	metal binding site 2 [ion binding]; metal-binding site
634177000998	putative DNA binding helix; other site
634177000999	metal binding site 1 [ion binding]; metal-binding site
634177001000	dimer interface [polypeptide binding]; other site
634177001001	structural Zn2+ binding site [ion binding]; other site
634177001002	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
634177001003	Ferritin-like domain; Region: Ferritin; pfam00210
634177001004	heme binding site [chemical binding]; other site
634177001005	ferroxidase pore; other site
634177001006	ferroxidase diiron center [ion binding]; other site
634177001007	Membrane transport protein; Region: Mem_trans; cl09117
634177001008	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
634177001009	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
634177001010	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
634177001011	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634177001012	dimer interface [polypeptide binding]; other site
634177001013	conserved gate region; other site
634177001014	putative PBP binding loops; other site
634177001015	ABC-ATPase subunit interface; other site
634177001016	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
634177001017	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634177001018	dimer interface [polypeptide binding]; other site
634177001019	conserved gate region; other site
634177001020	putative PBP binding loops; other site
634177001021	ABC-ATPase subunit interface; other site
634177001022	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
634177001023	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
634177001024	Walker A/P-loop; other site
634177001025	ATP binding site [chemical binding]; other site
634177001026	Q-loop/lid; other site
634177001027	ABC transporter signature motif; other site
634177001028	Walker B; other site
634177001029	D-loop; other site
634177001030	H-loop/switch region; other site
634177001031	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
634177001032	PhoU domain; Region: PhoU; pfam01895
634177001033	PhoU domain; Region: PhoU; pfam01895
634177001034	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
634177001035	FAD binding domain; Region: FAD_binding_4; pfam01565
634177001036	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
634177001037	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
634177001038	putative FMN binding site [chemical binding]; other site
634177001039	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634177001040	TPR motif; other site
634177001041	binding surface
634177001042	Tetratricopeptide repeat; Region: TPR_19; pfam14559
634177001043	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634177001044	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
634177001045	Rdx family; Region: Rdx; cl01407
634177001046	hydroperoxidase II; Provisional; Region: katE; PRK11249
634177001047	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
634177001048	heme binding pocket [chemical binding]; other site
634177001049	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
634177001050	domain interactions; other site
634177001051	Creatinine amidohydrolase; Region: Creatininase; pfam02633
634177001052	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
634177001053	Uncharacterized conserved protein [Function unknown]; Region: COG3391
634177001054	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
634177001055	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
634177001056	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
634177001057	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
634177001058	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
634177001059	DNA binding site [nucleotide binding]
634177001060	active site
634177001061	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
634177001062	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
634177001063	Cytochrome c; Region: Cytochrom_C; cl11414
634177001064	Cytochrome c; Region: Cytochrom_C; pfam00034
634177001065	Fusaric acid resistance protein-like; Region: FUSC_2; cl19401
634177001066	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634177001067	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634177001068	Fe2+ transport protein; Region: Iron_transport; cl01377
634177001069	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634177001070	Transposase; Region: HTH_Tnp_1; pfam01527
634177001071	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634177001072	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634177001073	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634177001074	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634177001075	zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005
634177001076	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634177001077	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634177001078	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
634177001079	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
634177001080	Zn binding site [ion binding]; other site
634177001081	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
634177001082	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
634177001083	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
634177001084	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
634177001085	catalytic residues [active]
634177001086	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
634177001087	nucleotide binding site [chemical binding]; other site
634177001088	putative NEF/HSP70 interaction site [polypeptide binding]; other site
634177001089	SBD interface [polypeptide binding]; other site
634177001090	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634177001091	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634177001092	Predicted acyl esterases [General function prediction only]; Region: COG2936
634177001093	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
634177001094	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
634177001095	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177001096	putative substrate translocation pore; other site
634177001097	POT family; Region: PTR2; cl17359
634177001098	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
634177001099	classical (c) SDRs; Region: SDR_c; cd05233
634177001100	NAD(P) binding site [chemical binding]; other site
634177001101	active site
634177001102	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
634177001103	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
634177001104	hypothetical protein; Provisional; Region: PRK10316
634177001105	YfdX protein; Region: YfdX; pfam10938
634177001106	General stress protein [General function prediction only]; Region: GsiB; COG3729
634177001107	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
634177001108	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
634177001109	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
634177001110	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
634177001111	Walker A/P-loop; other site
634177001112	ATP binding site [chemical binding]; other site
634177001113	Q-loop/lid; other site
634177001114	ABC transporter signature motif; other site
634177001115	Walker B; other site
634177001116	D-loop; other site
634177001117	H-loop/switch region; other site
634177001118	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
634177001119	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
634177001120	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
634177001121	Walker A/P-loop; other site
634177001122	ATP binding site [chemical binding]; other site
634177001123	Q-loop/lid; other site
634177001124	ABC transporter signature motif; other site
634177001125	Walker B; other site
634177001126	D-loop; other site
634177001127	H-loop/switch region; other site
634177001128	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
634177001129	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
634177001130	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634177001131	dimer interface [polypeptide binding]; other site
634177001132	conserved gate region; other site
634177001133	putative PBP binding loops; other site
634177001134	ABC-ATPase subunit interface; other site
634177001135	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
634177001136	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634177001137	dimer interface [polypeptide binding]; other site
634177001138	conserved gate region; other site
634177001139	putative PBP binding loops; other site
634177001140	ABC-ATPase subunit interface; other site
634177001141	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
634177001142	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
634177001143	substrate binding [chemical binding]; other site
634177001144	active site
634177001145	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
634177001146	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
634177001147	MMPL family; Region: MMPL; cl14618
634177001148	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
634177001149	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634177001150	HlyD family secretion protein; Region: HlyD_3; pfam13437
634177001151	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634177001152	Outer membrane efflux protein; Region: OEP; pfam02321
634177001153	Outer membrane efflux protein; Region: OEP; pfam02321
634177001154	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
634177001155	dimerization interface [polypeptide binding]; other site
634177001156	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221
634177001157	putative active cleft [active]
634177001158	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177001159	oxidoreductase; Provisional; Region: PRK06128
634177001160	NAD(P) binding site [chemical binding]; other site
634177001161	active site
634177001162	Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690
634177001163	Pirin-related protein [General function prediction only]; Region: COG1741
634177001164	Pirin; Region: Pirin; pfam02678
634177001165	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177001166	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177001167	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
634177001168	putative effector binding pocket; other site
634177001169	dimerization interface [polypeptide binding]; other site
634177001170	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
634177001171	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
634177001172	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
634177001173	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
634177001174	active site
634177001175	substrate binding site [chemical binding]; other site
634177001176	metal binding site [ion binding]; metal-binding site
634177001177	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
634177001178	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
634177001179	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
634177001180	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
634177001181	putative NAD(P) binding site [chemical binding]; other site
634177001182	putative substrate binding site [chemical binding]; other site
634177001183	catalytic Zn binding site [ion binding]; other site
634177001184	structural Zn binding site [ion binding]; other site
634177001185	dimer interface [polypeptide binding]; other site
634177001186	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
634177001187	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
634177001188	active site
634177001189	catalytic tetrad [active]
634177001190	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
634177001191	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
634177001192	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634177001193	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
634177001194	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
634177001195	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
634177001196	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
634177001197	Protein of unknown function (DUF1810); Region: DUF1810; cl02370
634177001198	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
634177001199	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
634177001200	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
634177001201	active site
634177001202	catalytic site [active]
634177001203	Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613
634177001204	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
634177001205	active site
634177001206	tetramer interface [polypeptide binding]; other site
634177001207	phenylhydantoinase; Validated; Region: PRK08323
634177001208	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
634177001209	tetramer interface [polypeptide binding]; other site
634177001210	active site
634177001211	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
634177001212	Na binding site [ion binding]; other site
634177001213	putative substrate binding site [chemical binding]; other site
634177001214	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177001215	putative substrate translocation pore; other site
634177001216	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
634177001217	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
634177001218	active site
634177001219	tetramer interface [polypeptide binding]; other site
634177001220	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634177001221	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634177001222	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
634177001223	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
634177001224	Nucleoside recognition; Region: Gate; pfam07670
634177001225	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
634177001226	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
634177001227	putative kinase; Provisional; Region: PRK09954
634177001228	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
634177001229	putative DNA binding site [nucleotide binding]; other site
634177001230	putative Zn2+ binding site [ion binding]; other site
634177001231	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
634177001232	substrate binding site [chemical binding]; other site
634177001233	ATP binding site [chemical binding]; other site
634177001234	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634177001235	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
634177001236	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
634177001237	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
634177001238	DNA-binding site [nucleotide binding]; DNA binding site
634177001239	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634177001240	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177001241	homodimer interface [polypeptide binding]; other site
634177001242	catalytic residue [active]
634177001243	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
634177001244	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
634177001245	inhibitor-cofactor binding pocket; inhibition site
634177001246	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177001247	catalytic residue [active]
634177001248	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
634177001249	Tautomerase enzyme; Region: Tautomerase_2; pfam14552
634177001250	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
634177001251	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
634177001252	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177001253	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634177001254	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
634177001255	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
634177001256	homodimer interface [polypeptide binding]; other site
634177001257	active site
634177001258	FMN binding site [chemical binding]; other site
634177001259	substrate binding site [chemical binding]; other site
634177001260	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
634177001261	allantoate amidohydrolase; Reviewed; Region: PRK09290
634177001262	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
634177001263	active site
634177001264	metal binding site [ion binding]; metal-binding site
634177001265	dimer interface [polypeptide binding]; other site
634177001266	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
634177001267	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
634177001268	Nucleoside recognition; Region: Gate; pfam07670
634177001269	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
634177001270	GrpB protein; Region: GrpB; pfam04229
634177001271	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634177001272	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634177001273	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
634177001274	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
634177001275	Active site cavity [active]
634177001276	catalytic acid [active]
634177001277	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
634177001278	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177001279	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
634177001280	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634177001281	HlyD family secretion protein; Region: HlyD_3; pfam13437
634177001282	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634177001283	Outer membrane efflux protein; Region: OEP; pfam02321
634177001284	Outer membrane efflux protein; Region: OEP; pfam02321
634177001285	Pirin-related protein [General function prediction only]; Region: COG1741
634177001286	Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774
634177001287	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; cl19952
634177001288	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
634177001289	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634177001290	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634177001291	zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005
634177001292	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634177001293	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634177001294	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634177001295	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634177001296	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634177001297	Transposase; Region: HTH_Tnp_1; pfam01527
634177001298	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177001299	Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477
634177001300	putative substrate translocation pore; other site
634177001301	B12 binding domain; Region: B12-binding; pfam02310
634177001302	B12 binding site [chemical binding]; other site
634177001303	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
634177001304	Radical SAM superfamily; Region: Radical_SAM; pfam04055
634177001305	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
634177001306	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
634177001307	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
634177001308	G2 box; other site
634177001309	Switch I region; other site
634177001310	G3 box; other site
634177001311	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
634177001312	Switch II region; other site
634177001313	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
634177001314	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
634177001315	dimer interface [polypeptide binding]; other site
634177001316	ADP-ribose binding site [chemical binding]; other site
634177001317	active site
634177001318	nudix motif; other site
634177001319	metal binding site [ion binding]; metal-binding site
634177001320	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
634177001321	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
634177001322	Probable Catalytic site; other site
634177001323	metal-binding site
634177001324	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634177001325	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
634177001326	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
634177001327	EamA-like transporter family; Region: EamA; pfam00892
634177001328	EamA-like transporter family; Region: EamA; pfam00892
634177001329	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
634177001330	putative deacylase active site [active]
634177001331	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
634177001332	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
634177001333	active site
634177001334	putative substrate binding pocket [chemical binding]; other site
634177001335	Cupin domain; Region: Cupin_2; cl17218
634177001336	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645
634177001337	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
634177001338	PAS fold; Region: PAS_2; pfam08446
634177001339	GAF domain; Region: GAF; pfam01590
634177001340	Phytochrome region; Region: PHY; pfam00360
634177001341	HWE histidine kinase; Region: HWE_HK; pfam07536
634177001342	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177001343	active site
634177001344	phosphorylation site [posttranslational modification]
634177001345	intermolecular recognition site; other site
634177001346	dimerization interface [polypeptide binding]; other site
634177001347	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
634177001348	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
634177001349	putative active site [active]
634177001350	heme pocket [chemical binding]; other site
634177001351	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
634177001352	putative active site [active]
634177001353	heme pocket [chemical binding]; other site
634177001354	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
634177001355	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
634177001356	metal binding site [ion binding]; metal-binding site
634177001357	active site
634177001358	I-site; other site
634177001359	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
634177001360	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634177001361	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
634177001362	active site
634177001363	H+ Antiporter protein; Region: 2A0121; TIGR00900
634177001364	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177001365	putative substrate translocation pore; other site
634177001366	AAA domain; Region: AAA_11; pfam13086
634177001367	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177001368	AAA domain; Region: AAA_22; pfam13401
634177001369	Walker A motif; other site
634177001370	ATP binding site [chemical binding]; other site
634177001371	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
634177001372	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
634177001373	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
634177001374	ligand binding site [chemical binding]; other site
634177001375	flexible hinge region; other site
634177001376	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
634177001377	putative switch regulator; other site
634177001378	non-specific DNA interactions [nucleotide binding]; other site
634177001379	DNA binding site [nucleotide binding]
634177001380	sequence specific DNA binding site [nucleotide binding]; other site
634177001381	putative cAMP binding site [chemical binding]; other site
634177001382	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
634177001383	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
634177001384	putative active site [active]
634177001385	heme pocket [chemical binding]; other site
634177001386	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
634177001387	metal binding site [ion binding]; metal-binding site
634177001388	active site
634177001389	I-site; other site
634177001390	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
634177001391	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
634177001392	PAS domain; Region: PAS_9; pfam13426
634177001393	putative active site [active]
634177001394	heme pocket [chemical binding]; other site
634177001395	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
634177001396	metal binding site [ion binding]; metal-binding site
634177001397	active site
634177001398	I-site; other site
634177001399	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
634177001400	Transcriptional regulator; Region: Rrf2; cl17282
634177001401	Rrf2 family protein; Region: rrf2_super; TIGR00738
634177001402	Transcriptional regulator; Region: Rrf2; cl17282
634177001403	Rrf2 family protein; Region: rrf2_super; TIGR00738
634177001404	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
634177001405	DEC-1 protein, N-terminal region; Region: DEC-1_N; pfam04625
634177001406	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
634177001407	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
634177001408	Trp docking motif [polypeptide binding]; other site
634177001409	putative active site [active]
634177001410	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
634177001411	Domain of unknown function (DUF333); Region: DUF333; pfam03891
634177001412	Putative lysophospholipase; Region: Hydrolase_4; cl19140
634177001413	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634177001414	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
634177001415	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
634177001416	FMN binding site [chemical binding]; other site
634177001417	active site
634177001418	substrate binding site [chemical binding]; other site
634177001419	catalytic residue [active]
634177001420	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
634177001421	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
634177001422	Leucine carboxyl methyltransferase; Region: LCM; cl01306
634177001423	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
634177001424	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177001425	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177001426	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
634177001427	putative dimerization interface [polypeptide binding]; other site
634177001428	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; cl01562
634177001429	YceI-like domain; Region: YceI; pfam04264
634177001430	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634177001431	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634177001432	non-specific DNA binding site [nucleotide binding]; other site
634177001433	salt bridge; other site
634177001434	sequence-specific DNA binding site [nucleotide binding]; other site
634177001435	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634177001436	non-specific DNA binding site [nucleotide binding]; other site
634177001437	salt bridge; other site
634177001438	sequence-specific DNA binding site [nucleotide binding]; other site
634177001439	Predicted transcriptional regulator [Transcription]; Region: COG2932
634177001440	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
634177001441	Catalytic site [active]
634177001442	Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; pfam09250
634177001443	nucleotide binding site [chemical binding]; other site
634177001444	Virulence-associated protein E; Region: VirE; pfam05272
634177001445	EamA-like transporter family; Region: EamA; pfam00892
634177001446	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
634177001447	EamA-like transporter family; Region: EamA; pfam00892
634177001448	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
634177001449	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
634177001450	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
634177001451	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
634177001452	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
634177001453	conserved cys residue [active]
634177001454	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634177001455	Phage terminase large subunit; Region: Terminase_3; cl12054
634177001456	Terminase-like family; Region: Terminase_6; pfam03237
634177001457	Uncharacterized conserved protein [Function unknown]; Region: COG5323
634177001458	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
634177001459	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; cl19531
634177001460	flagellin; Reviewed; Region: PRK12688
634177001461	RecT family; Region: RecT; cl04285
634177001462	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
634177001463	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
634177001464	Baseplate J-like protein; Region: Baseplate_J; cl01294
634177001465	Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582
634177001466	virion protein; Provisional; Region: V; PHA02564
634177001467	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
634177001468	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
634177001469	FMN binding site [chemical binding]; other site
634177001470	substrate binding site [chemical binding]; other site
634177001471	putative catalytic residue [active]
634177001472	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
634177001473	MgtC family; Region: MgtC; pfam02308
634177001474	Protein of unknown function (DUF952); Region: DUF952; pfam06108
634177001475	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
634177001476	classical (c) SDRs; Region: SDR_c; cd05233
634177001477	NAD(P) binding site [chemical binding]; other site
634177001478	active site
634177001479	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177001480	active site
634177001481	Secretory lipase; Region: LIP; pfam03583
634177001482	putative sialic acid transporter; Region: 2A0112; TIGR00891
634177001483	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177001484	putative substrate translocation pore; other site
634177001485	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634177001486	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
634177001487	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
634177001488	putative active site [active]
634177001489	heme pocket [chemical binding]; other site
634177001490	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
634177001491	metal binding site [ion binding]; metal-binding site
634177001492	active site
634177001493	I-site; other site
634177001494	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
634177001495	PAS fold; Region: PAS; pfam00989
634177001496	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
634177001497	putative active site [active]
634177001498	heme pocket [chemical binding]; other site
634177001499	Transposase domain (DUF772); Region: DUF772; pfam05598
634177001500	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177001501	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177001502	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634177001503	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634177001504	catalytic residues [active]
634177001505	catalytic nucleophile [active]
634177001506	Presynaptic Site I dimer interface [polypeptide binding]; other site
634177001507	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634177001508	Synaptic Flat tetramer interface [polypeptide binding]; other site
634177001509	Synaptic Site I dimer interface [polypeptide binding]; other site
634177001510	DNA binding site [nucleotide binding]
634177001511	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393
634177001512	DNA-binding interface [nucleotide binding]; DNA binding site
634177001513	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634177001514	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634177001515	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
634177001516	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634177001517	active site
634177001518	Purine nucleoside permease (NUP); Region: NUP; cl17832
634177001519	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208
634177001520	CAS motifs; other site
634177001521	active site
634177001522	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
634177001523	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
634177001524	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
634177001525	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
634177001526	DNA-binding site [nucleotide binding]; DNA binding site
634177001527	UTRA domain; Region: UTRA; pfam07702
634177001528	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
634177001529	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
634177001530	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634177001531	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634177001532	active site
634177001533	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
634177001534	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
634177001535	Bacterial transcriptional regulator; Region: IclR; pfam01614
634177001536	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
634177001537	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
634177001538	FAD binding site [chemical binding]; other site
634177001539	Secretory lipase; Region: LIP; pfam03583
634177001540	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634177001541	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
634177001542	active site
634177001543	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634177001544	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634177001545	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
634177001546	active site
634177001547	Integrase core domain; Region: rve; pfam00665
634177001548	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
634177001549	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
634177001550	GatB domain; Region: GatB_Yqey; smart00845
634177001551	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
634177001552	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
634177001553	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
634177001554	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
634177001555	amphipathic channel; other site
634177001556	Asn-Pro-Ala signature motifs; other site
634177001557	Dak1 domain; Region: Dak1; cl10557
634177001558	dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361
634177001559	DAK2 domain; Region: Dak2; pfam02734
634177001560	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
634177001561	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
634177001562	PhnA protein; Region: PhnA; pfam03831
634177001563	cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776
634177001564	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
634177001565	phosphoglucomutase; Validated; Region: PRK07564
634177001566	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
634177001567	active site
634177001568	substrate binding site [chemical binding]; other site
634177001569	metal binding site [ion binding]; metal-binding site
634177001570	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
634177001571	metal binding site 2 [ion binding]; metal-binding site
634177001572	putative DNA binding helix; other site
634177001573	metal binding site 1 [ion binding]; metal-binding site
634177001574	dimer interface [polypeptide binding]; other site
634177001575	structural Zn2+ binding site [ion binding]; other site
634177001576	Predicted kinase [General function prediction only]; Region: COG4857; cl17281
634177001577	Phosphotransferase enzyme family; Region: APH; pfam01636
634177001578	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
634177001579	HsdM N-terminal domain; Region: HsdM_N; pfam12161
634177001580	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177001581	S-adenosylmethionine binding site [chemical binding]; other site
634177001582	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
634177001583	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
634177001584	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
634177001585	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
634177001586	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
634177001587	Strabismus protein; Region: Strabismus; pfam06638
634177001588	Superinfection immunity protein; Region: Imm_superinfect; pfam14373
634177001589	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
634177001590	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
634177001591	ligand binding site [chemical binding]; other site
634177001592	NAD binding site [chemical binding]; other site
634177001593	tetramer interface [polypeptide binding]; other site
634177001594	catalytic site [active]
634177001595	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
634177001596	L-serine binding site [chemical binding]; other site
634177001597	ACT domain interface; other site
634177001598	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
634177001599	active site
634177001600	Cytochrome c; Region: Cytochrom_C; cl11414
634177001601	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
634177001602	Ligand binding site; other site
634177001603	oligomer interface; other site
634177001604	prephenate dehydratase; Provisional; Region: PRK11899
634177001605	Prephenate dehydratase; Region: PDT; pfam00800
634177001606	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
634177001607	putative L-Phe binding site [chemical binding]; other site
634177001608	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
634177001609	dimer interface [polypeptide binding]; other site
634177001610	active site
634177001611	catalytic residue [active]
634177001612	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
634177001613	SmpB-tmRNA interface; other site
634177001614	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
634177001615	DNA-binding site [nucleotide binding]; DNA binding site
634177001616	RNA-binding motif; other site
634177001617	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
634177001618	DNA-binding site [nucleotide binding]; DNA binding site
634177001619	RNA-binding motif; other site
634177001620	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634177001621	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634177001622	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
634177001623	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
634177001624	generic binding surface II; other site
634177001625	ssDNA binding site; other site
634177001626	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634177001627	ATP binding site [chemical binding]; other site
634177001628	putative Mg++ binding site [ion binding]; other site
634177001629	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634177001630	nucleotide binding region [chemical binding]; other site
634177001631	ATP-binding site [chemical binding]; other site
634177001632	Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937
634177001633	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
634177001634	Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
634177001635	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
634177001636	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634177001637	ATP binding site [chemical binding]; other site
634177001638	putative Mg++ binding site [ion binding]; other site
634177001639	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634177001640	nucleotide binding region [chemical binding]; other site
634177001641	ATP-binding site [chemical binding]; other site
634177001642	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
634177001643	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
634177001644	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
634177001645	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634177001646	catalytic residue [active]
634177001647	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
634177001648	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
634177001649	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
634177001650	metal ion-dependent adhesion site (MIDAS); other site
634177001651	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
634177001652	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
634177001653	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
634177001654	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
634177001655	HSP70 interaction site [polypeptide binding]; other site
634177001656	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
634177001657	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192
634177001658	lipoate-protein ligase B; Provisional; Region: PRK14341
634177001659	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
634177001660	active site
634177001661	tetramer interface; other site
634177001662	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
634177001663	active site
634177001664	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
634177001665	substrate binding site [chemical binding]; other site
634177001666	metal binding site [ion binding]; metal-binding site
634177001667	Protein of unknown function (DUF3553); Region: DUF3553; pfam12073
634177001668	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
634177001669	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634177001670	FeS/SAM binding site; other site
634177001671	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
634177001672	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
634177001673	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177001674	S-adenosylmethionine binding site [chemical binding]; other site
634177001675	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
634177001676	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634177001677	active site
634177001678	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
634177001679	GSH binding site [chemical binding]; other site
634177001680	catalytic residues [active]
634177001681	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
634177001682	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
634177001683	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
634177001684	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
634177001685	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177001686	S-adenosylmethionine binding site [chemical binding]; other site
634177001687	aspartate kinase; Reviewed; Region: PRK06635
634177001688	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
634177001689	putative nucleotide binding site [chemical binding]; other site
634177001690	putative catalytic residues [active]
634177001691	putative Mg ion binding site [ion binding]; other site
634177001692	putative aspartate binding site [chemical binding]; other site
634177001693	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
634177001694	putative allosteric regulatory site; other site
634177001695	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
634177001696	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
634177001697	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
634177001698	FMN binding site [chemical binding]; other site
634177001699	substrate binding site [chemical binding]; other site
634177001700	putative catalytic residue [active]
634177001701	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
634177001702	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634177001703	non-specific DNA binding site [nucleotide binding]; other site
634177001704	salt bridge; other site
634177001705	sequence-specific DNA binding site [nucleotide binding]; other site
634177001706	Protein of unknown function (DUF3275); Region: DUF3275; pfam11679
634177001707	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
634177001708	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
634177001709	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
634177001710	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
634177001711	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
634177001712	dimer interface [polypeptide binding]; other site
634177001713	motif 1; other site
634177001714	active site
634177001715	motif 2; other site
634177001716	motif 3; other site
634177001717	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
634177001718	anticodon binding site; other site
634177001719	peptide chain release factor 1; Validated; Region: prfA; PRK00591
634177001720	PCRF domain; Region: PCRF; pfam03462
634177001721	RF-1 domain; Region: RF-1; pfam00472
634177001722	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
634177001723	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177001724	S-adenosylmethionine binding site [chemical binding]; other site
634177001725	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
634177001726	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
634177001727	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
634177001728	inhibitor-cofactor binding pocket; inhibition site
634177001729	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177001730	catalytic residue [active]
634177001731	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
634177001732	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
634177001733	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634177001734	catalytic residue [active]
634177001735	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634177001736	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
634177001737	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177001738	S-adenosylmethionine binding site [chemical binding]; other site
634177001739	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
634177001740	AAA domain; Region: AAA_26; pfam13500
634177001741	LexA repressor; Validated; Region: PRK00215
634177001742	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
634177001743	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
634177001744	Catalytic site [active]
634177001745	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
634177001746	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
634177001747	dimer interface [polypeptide binding]; other site
634177001748	putative functional site; other site
634177001749	putative MPT binding site; other site
634177001750	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
634177001751	Septum formation initiator; Region: DivIC; cl17659
634177001752	enolase; Provisional; Region: eno; PRK00077
634177001753	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
634177001754	dimer interface [polypeptide binding]; other site
634177001755	metal binding site [ion binding]; metal-binding site
634177001756	substrate binding pocket [chemical binding]; other site
634177001757	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
634177001758	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
634177001759	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634177001760	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
634177001761	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634177001762	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
634177001763	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634177001764	catalytic loop [active]
634177001765	iron binding site [ion binding]; other site
634177001766	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
634177001767	Cytochrome c; Region: Cytochrom_C; pfam00034
634177001768	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634177001769	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
634177001770	Cytochrome c; Region: Cytochrom_C; pfam00034
634177001771	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
634177001772	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
634177001773	Trp docking motif [polypeptide binding]; other site
634177001774	putative active site [active]
634177001775	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
634177001776	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
634177001777	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
634177001778	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634177001779	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
634177001780	putative ADP-binding pocket [chemical binding]; other site
634177001781	replicative DNA helicase; Provisional; Region: PRK09165
634177001782	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
634177001783	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
634177001784	Walker A motif; other site
634177001785	ATP binding site [chemical binding]; other site
634177001786	Walker B motif; other site
634177001787	DNA binding loops [nucleotide binding]
634177001788	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
634177001789	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
634177001790	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177001791	Walker A motif; other site
634177001792	ATP binding site [chemical binding]; other site
634177001793	Walker B motif; other site
634177001794	arginine finger; other site
634177001795	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
634177001796	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
634177001797	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
634177001798	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
634177001799	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634177001800	ATP binding site [chemical binding]; other site
634177001801	Mg++ binding site [ion binding]; other site
634177001802	motif III; other site
634177001803	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634177001804	nucleotide binding region [chemical binding]; other site
634177001805	ATP-binding site [chemical binding]; other site
634177001806	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
634177001807	active site
634177001808	Zn binding site [ion binding]; other site
634177001809	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
634177001810	dimer interface [polypeptide binding]; other site
634177001811	active site
634177001812	glycine-pyridoxal phosphate binding site [chemical binding]; other site
634177001813	folate binding site [chemical binding]; other site
634177001814	amino acid transporter; Region: 2A0306; TIGR00909
634177001815	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
634177001816	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
634177001817	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
634177001818	dimer interface [polypeptide binding]; other site
634177001819	active site
634177001820	aspartate-rich active site metal binding site; other site
634177001821	allosteric magnesium binding site [ion binding]; other site
634177001822	Schiff base residues; other site
634177001823	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
634177001824	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
634177001825	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
634177001826	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
634177001827	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
634177001828	CAP-like domain; other site
634177001829	active site
634177001830	primary dimer interface [polypeptide binding]; other site
634177001831	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
634177001832	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
634177001833	Recombination protein O N terminal; Region: RecO_N; pfam11967
634177001834	Recombination protein O C terminal; Region: RecO_C; pfam02565
634177001835	elongation factor Ts; Provisional; Region: tsf; PRK09377
634177001836	UBA/TS-N domain; Region: UBA; pfam00627
634177001837	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
634177001838	rRNA interaction site [nucleotide binding]; other site
634177001839	S8 interaction site; other site
634177001840	putative laminin-1 binding site; other site
634177001841	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
634177001842	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
634177001843	Tetramer interface [polypeptide binding]; other site
634177001844	active site
634177001845	FMN-binding site [chemical binding]; other site
634177001846	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
634177001847	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
634177001848	NAD binding site [chemical binding]; other site
634177001849	homotetramer interface [polypeptide binding]; other site
634177001850	homodimer interface [polypeptide binding]; other site
634177001851	substrate binding site [chemical binding]; other site
634177001852	active site
634177001853	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
634177001854	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
634177001855	Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590
634177001856	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
634177001857	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
634177001858	Ligand Binding Site [chemical binding]; other site
634177001859	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
634177001860	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
634177001861	Active Sites [active]
634177001862	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
634177001863	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
634177001864	Active Sites [active]
634177001865	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
634177001866	CysD dimerization site [polypeptide binding]; other site
634177001867	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
634177001868	G1 box; other site
634177001869	putative GEF interaction site [polypeptide binding]; other site
634177001870	GTP/Mg2+ binding site [chemical binding]; other site
634177001871	Switch I region; other site
634177001872	G2 box; other site
634177001873	G3 box; other site
634177001874	Switch II region; other site
634177001875	G4 box; other site
634177001876	G5 box; other site
634177001877	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
634177001878	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
634177001879	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
634177001880	ligand-binding site [chemical binding]; other site
634177001881	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
634177001882	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
634177001883	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
634177001884	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
634177001885	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
634177001886	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
634177001887	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
634177001888	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
634177001889	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
634177001890	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
634177001891	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
634177001892	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
634177001893	putative acyl-acceptor binding pocket; other site
634177001894	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
634177001895	putative ligand binding site [chemical binding]; other site
634177001896	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
634177001897	putative SAM binding site [chemical binding]; other site
634177001898	putative homodimer interface [polypeptide binding]; other site
634177001899	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
634177001900	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
634177001901	diiron binding motif [ion binding]; other site
634177001902	CCC1-related protein family; Region: CCC1_like_1; cd02437
634177001903	glutamate--cysteine ligase; Region: PLN02611
634177001904	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
634177001905	4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959
634177001906	putative active site [active]
634177001907	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
634177001908	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
634177001909	GntP family permease; Region: GntP_permease; pfam02447
634177001910	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
634177001911	catalytic triad [active]
634177001912	metal binding site [ion binding]; metal-binding site
634177001913	conserved cis-peptide bond; other site
634177001914	GTP-binding protein Der; Reviewed; Region: PRK00093
634177001915	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
634177001916	G1 box; other site
634177001917	GTP/Mg2+ binding site [chemical binding]; other site
634177001918	Switch I region; other site
634177001919	G2 box; other site
634177001920	Switch II region; other site
634177001921	G3 box; other site
634177001922	G4 box; other site
634177001923	G5 box; other site
634177001924	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
634177001925	G1 box; other site
634177001926	GTP/Mg2+ binding site [chemical binding]; other site
634177001927	Switch I region; other site
634177001928	G2 box; other site
634177001929	G3 box; other site
634177001930	Switch II region; other site
634177001931	G4 box; other site
634177001932	G5 box; other site
634177001933	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714
634177001934	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
634177001935	Trp docking motif [polypeptide binding]; other site
634177001936	active site
634177001937	PQQ-like domain; Region: PQQ_2; pfam13360
634177001938	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
634177001939	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
634177001940	putative active site [active]
634177001941	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
634177001942	Aminomethyltransferase folate-binding domain; Region: GCV_T; cl01893
634177001943	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
634177001944	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
634177001945	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
634177001946	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
634177001947	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
634177001948	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
634177001949	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
634177001950	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
634177001951	putative tRNA-binding site [nucleotide binding]; other site
634177001952	B3/4 domain; Region: B3_4; pfam03483
634177001953	tRNA synthetase B5 domain; Region: B5; smart00874
634177001954	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
634177001955	dimer interface [polypeptide binding]; other site
634177001956	motif 1; other site
634177001957	motif 3; other site
634177001958	motif 2; other site
634177001959	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
634177001960	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
634177001961	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
634177001962	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
634177001963	dimer interface [polypeptide binding]; other site
634177001964	motif 1; other site
634177001965	active site
634177001966	motif 2; other site
634177001967	motif 3; other site
634177001968	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
634177001969	23S rRNA binding site [nucleotide binding]; other site
634177001970	L21 binding site [polypeptide binding]; other site
634177001971	L13 binding site [polypeptide binding]; other site
634177001972	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
634177001973	oxidoreductase; Provisional; Region: PRK12742
634177001974	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177001975	NAD(P) binding site [chemical binding]; other site
634177001976	active site
634177001977	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
634177001978	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483
634177001979	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177001980	S-adenosylmethionine binding site [chemical binding]; other site
634177001981	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
634177001982	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
634177001983	nucleotide binding site [chemical binding]; other site
634177001984	Glucokinase; Region: Glucokinase; cl17310
634177001985	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
634177001986	CPxP  motif; other site
634177001987	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
634177001988	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
634177001989	substrate binding pocket [chemical binding]; other site
634177001990	chain length determination region; other site
634177001991	active site lid residues [active]
634177001992	substrate-Mg2+ binding site; other site
634177001993	catalytic residues [active]
634177001994	aspartate-rich region 1; other site
634177001995	aspartate-rich region 2; other site
634177001996	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
634177001997	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
634177001998	TPP-binding site; other site
634177001999	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
634177002000	PYR/PP interface [polypeptide binding]; other site
634177002001	dimer interface [polypeptide binding]; other site
634177002002	TPP binding site [chemical binding]; other site
634177002003	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634177002004	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
634177002005	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634177002006	RNA binding surface [nucleotide binding]; other site
634177002007	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177002008	S-adenosylmethionine binding site [chemical binding]; other site
634177002009	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
634177002010	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634177002011	FeS/SAM binding site; other site
634177002012	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
634177002013	ANP binding site [chemical binding]; other site
634177002014	Substrate Binding Site II [chemical binding]; other site
634177002015	Substrate Binding Site I [chemical binding]; other site
634177002016	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
634177002017	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634177002018	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
634177002019	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927
634177002020	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
634177002021	active site
634177002022	HIGH motif; other site
634177002023	dimer interface [polypeptide binding]; other site
634177002024	KMSKS motif; other site
634177002025	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
634177002026	Predicted esterase [General function prediction only]; Region: COG0627
634177002027	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
634177002028	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
634177002029	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
634177002030	substrate binding site [chemical binding]; other site
634177002031	catalytic Zn binding site [ion binding]; other site
634177002032	NAD binding site [chemical binding]; other site
634177002033	structural Zn binding site [ion binding]; other site
634177002034	dimer interface [polypeptide binding]; other site
634177002035	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
634177002036	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
634177002037	putative transporter; Provisional; Region: PRK12382
634177002038	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177002039	putative substrate translocation pore; other site
634177002040	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
634177002041	Family of unknown function (DUF490); Region: DUF490; pfam04357
634177002042	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
634177002043	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634177002044	Surface antigen; Region: Bac_surface_Ag; pfam01103
634177002045	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
634177002046	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
634177002047	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634177002048	FeS/SAM binding site; other site
634177002049	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
634177002050	PhoH-like protein; Region: PhoH; pfam02562
634177002051	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
634177002052	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
634177002053	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
634177002054	Transporter associated domain; Region: CorC_HlyC; smart01091
634177002055	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
634177002056	Thioredoxin; Region: Thioredoxin_4; pfam13462
634177002057	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
634177002058	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
634177002059	Walker A/P-loop; other site
634177002060	ATP binding site [chemical binding]; other site
634177002061	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
634177002062	ABC transporter signature motif; other site
634177002063	Walker B; other site
634177002064	D-loop; other site
634177002065	H-loop/switch region; other site
634177002066	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
634177002067	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
634177002068	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
634177002069	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
634177002070	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
634177002071	active site
634177002072	metal binding site [ion binding]; metal-binding site
634177002073	chorismate mutase; Provisional; Region: PRK09239
634177002074	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634177002075	catalytic core [active]
634177002076	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
634177002077	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
634177002078	dimer interface [polypeptide binding]; other site
634177002079	active site
634177002080	citrylCoA binding site [chemical binding]; other site
634177002081	NADH binding [chemical binding]; other site
634177002082	cationic pore residues; other site
634177002083	oxalacetate/citrate binding site [chemical binding]; other site
634177002084	coenzyme A binding site [chemical binding]; other site
634177002085	catalytic triad [active]
634177002086	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634177002087	active site
634177002088	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
634177002089	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
634177002090	substrate binding pocket [chemical binding]; other site
634177002091	chain length determination region; other site
634177002092	substrate-Mg2+ binding site; other site
634177002093	catalytic residues [active]
634177002094	aspartate-rich region 1; other site
634177002095	active site lid residues [active]
634177002096	aspartate-rich region 2; other site
634177002097	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
634177002098	Methyltransferase domain; Region: Methyltransf_26; pfam13659
634177002099	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
634177002100	dimer interface [polypeptide binding]; other site
634177002101	putative radical transfer pathway; other site
634177002102	diiron center [ion binding]; other site
634177002103	tyrosyl radical; other site
634177002104	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
634177002105	Class I ribonucleotide reductase; Region: RNR_I; cd01679
634177002106	active site
634177002107	dimer interface [polypeptide binding]; other site
634177002108	catalytic residues [active]
634177002109	effector binding site; other site
634177002110	R2 peptide binding site; other site
634177002111	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
634177002112	MoaE homodimer interface [polypeptide binding]; other site
634177002113	MoaD interaction [polypeptide binding]; other site
634177002114	active site residues [active]
634177002115	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
634177002116	MoaE interaction surface [polypeptide binding]; other site
634177002117	MoeB interaction surface [polypeptide binding]; other site
634177002118	thiocarboxylated glycine; other site
634177002119	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
634177002120	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
634177002121	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
634177002122	GIY-YIG motif/motif A; other site
634177002123	active site
634177002124	catalytic site [active]
634177002125	putative DNA binding site [nucleotide binding]; other site
634177002126	metal binding site [ion binding]; metal-binding site
634177002127	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
634177002128	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
634177002129	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
634177002130	putative catalytic site [active]
634177002131	putative phosphate binding site [ion binding]; other site
634177002132	active site
634177002133	metal binding site A [ion binding]; metal-binding site
634177002134	DNA binding site [nucleotide binding]
634177002135	putative AP binding site [nucleotide binding]; other site
634177002136	putative metal binding site B [ion binding]; other site
634177002137	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634177002138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177002139	active site
634177002140	phosphorylation site [posttranslational modification]
634177002141	intermolecular recognition site; other site
634177002142	dimerization interface [polypeptide binding]; other site
634177002143	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634177002144	DNA binding site [nucleotide binding]
634177002145	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
634177002146	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634177002147	TrkA-N domain; Region: TrkA_N; pfam02254
634177002148	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
634177002149	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177002150	S-adenosylmethionine binding site [chemical binding]; other site
634177002151	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
634177002152	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
634177002153	active site
634177002154	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
634177002155	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
634177002156	active site
634177002157	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
634177002158	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
634177002159	active site
634177002160	HIGH motif; other site
634177002161	KMSKS motif; other site
634177002162	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
634177002163	tRNA binding surface [nucleotide binding]; other site
634177002164	anticodon binding site; other site
634177002165	DNA polymerase III subunit delta'; Validated; Region: PRK09112
634177002166	DNA polymerase III subunit delta'; Validated; Region: PRK08485
634177002167	thymidylate kinase; Validated; Region: tmk; PRK00698
634177002168	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
634177002169	TMP-binding site; other site
634177002170	ATP-binding site [chemical binding]; other site
634177002171	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
634177002172	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
634177002173	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
634177002174	lytic murein transglycosylase; Region: MltB_2; TIGR02283
634177002175	Transglycosylase SLT domain; Region: SLT_2; pfam13406
634177002176	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
634177002177	cyanophycin synthetase; Provisional; Region: PRK14016
634177002178	mce related protein; Region: MCE; pfam02470
634177002179	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
634177002180	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
634177002181	Mechanosensitive ion channel; Region: MS_channel; pfam00924
634177002182	EcsC protein family; Region: EcsC; pfam12787
634177002183	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
634177002184	Rhodanese-like domain; Region: Rhodanese; pfam00581
634177002185	active site residue [active]
634177002186	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
634177002187	active site residue [active]
634177002188	CsbD-like; Region: CsbD; pfam05532
634177002189	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
634177002190	Uncharacterized conserved protein [Function unknown]; Region: COG3410
634177002191	Haemolysin-III related; Region: HlyIII; cl03831
634177002192	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
634177002193	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177002194	putative substrate translocation pore; other site
634177002195	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
634177002196	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
634177002197	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
634177002198	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
634177002199	NAD binding site [chemical binding]; other site
634177002200	substrate binding site [chemical binding]; other site
634177002201	catalytic Zn binding site [ion binding]; other site
634177002202	tetramer interface [polypeptide binding]; other site
634177002203	structural Zn binding site [ion binding]; other site
634177002204	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
634177002205	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634177002206	catalytic residue [active]
634177002207	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
634177002208	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
634177002209	active site residue [active]
634177002210	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
634177002211	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
634177002212	active site residue [active]
634177002213	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
634177002214	Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372
634177002215	putative catalytic site [active]
634177002216	putative metal binding site [ion binding]; other site
634177002217	putative phosphate binding site [ion binding]; other site
634177002218	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
634177002219	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
634177002220	putative active site [active]
634177002221	catalytic site [active]
634177002222	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
634177002223	putative active site [active]
634177002224	catalytic site [active]
634177002225	hypothetical protein; Reviewed; Region: PRK12497
634177002226	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
634177002227	putative GSH binding site [chemical binding]; other site
634177002228	catalytic residues [active]
634177002229	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
634177002230	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
634177002231	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
634177002232	dimerization interface [polypeptide binding]; other site
634177002233	ATP binding site [chemical binding]; other site
634177002234	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
634177002235	dimerization interface [polypeptide binding]; other site
634177002236	ATP binding site [chemical binding]; other site
634177002237	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
634177002238	putative active site [active]
634177002239	catalytic triad [active]
634177002240	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
634177002241	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
634177002242	ATP binding site [chemical binding]; other site
634177002243	active site
634177002244	substrate binding site [chemical binding]; other site
634177002245	NRDE protein; Region: NRDE; cl01315
634177002246	adenylosuccinate lyase; Provisional; Region: PRK07492
634177002247	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
634177002248	tetramer interface [polypeptide binding]; other site
634177002249	active site
634177002250	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
634177002251	Integral membrane protein TerC family; Region: TerC; cl10468
634177002252	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634177002253	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634177002254	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634177002255	catalytic residue [active]
634177002256	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
634177002257	tetramer interfaces [polypeptide binding]; other site
634177002258	binuclear metal-binding site [ion binding]; other site
634177002259	Competence-damaged protein; Region: CinA; pfam02464
634177002260	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
634177002261	putative coenzyme Q binding site [chemical binding]; other site
634177002262	lipoyl synthase; Provisional; Region: PRK05481
634177002263	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634177002264	FeS/SAM binding site; other site
634177002265	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
634177002266	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634177002267	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
634177002268	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634177002269	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
634177002270	E3 interaction surface; other site
634177002271	lipoyl attachment site [posttranslational modification]; other site
634177002272	e3 binding domain; Region: E3_binding; pfam02817
634177002273	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
634177002274	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
634177002275	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634177002276	E3 interaction surface; other site
634177002277	lipoyl attachment site [posttranslational modification]; other site
634177002278	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
634177002279	alpha subunit interface [polypeptide binding]; other site
634177002280	TPP binding site [chemical binding]; other site
634177002281	heterodimer interface [polypeptide binding]; other site
634177002282	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634177002283	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
634177002284	tetramer interface [polypeptide binding]; other site
634177002285	TPP-binding site [chemical binding]; other site
634177002286	heterodimer interface [polypeptide binding]; other site
634177002287	phosphorylation loop region [posttranslational modification]
634177002288	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
634177002289	trimer interface [polypeptide binding]; other site
634177002290	dimer interface [polypeptide binding]; other site
634177002291	putative active site [active]
634177002292	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
634177002293	active site
634177002294	ribulose/triose binding site [chemical binding]; other site
634177002295	phosphate binding site [ion binding]; other site
634177002296	substrate (anthranilate) binding pocket [chemical binding]; other site
634177002297	product (indole) binding pocket [chemical binding]; other site
634177002298	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
634177002299	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
634177002300	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
634177002301	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
634177002302	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
634177002303	glutamine binding [chemical binding]; other site
634177002304	catalytic triad [active]
634177002305	anthranilate synthase component I; Provisional; Region: PRK13573
634177002306	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
634177002307	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
634177002308	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
634177002309	SurA N-terminal domain; Region: SurA_N_3; cl07813
634177002310	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
634177002311	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
634177002312	substrate binding site [chemical binding]; other site
634177002313	dimer interface [polypeptide binding]; other site
634177002314	catalytic triad [active]
634177002315	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
634177002316	CTP synthetase; Validated; Region: pyrG; PRK05380
634177002317	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
634177002318	Catalytic site [active]
634177002319	active site
634177002320	UTP binding site [chemical binding]; other site
634177002321	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
634177002322	active site
634177002323	putative oxyanion hole; other site
634177002324	catalytic triad [active]
634177002325	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
634177002326	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634177002327	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634177002328	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; cl19502
634177002329	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
634177002330	PAS domain; Region: PAS; smart00091
634177002331	PAS domain S-box; Region: sensory_box; TIGR00229
634177002332	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
634177002333	metal binding site [ion binding]; metal-binding site
634177002334	active site
634177002335	I-site; other site
634177002336	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
634177002337	Phosphate-selective porin O and P; Region: Porin_O_P; cl19535
634177002338	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
634177002339	ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505
634177002340	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
634177002341	putative ssRNA endonuclease; Provisional; Region: PRK11558
634177002342	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
634177002343	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
634177002344	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348
634177002345	CT1975-like protein; Region: Cas_CT1975; pfam09344
634177002346	CRISPR-associated protein Cse2 (CRISPR_cse2); Region: CRISPR_Cse2; pfam09485
634177002347	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
634177002348	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
634177002349	CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639
634177002350	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
634177002351	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
634177002352	NAD(P) binding site [chemical binding]; other site
634177002353	catalytic residues [active]
634177002354	Tetratricopeptide repeat; Region: TPR_16; pfam13432
634177002355	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
634177002356	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
634177002357	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
634177002358	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
634177002359	DXD motif; other site
634177002360	PilZ domain; Region: PilZ; pfam07238
634177002361	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
634177002362	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
634177002363	E-class dimer interface [polypeptide binding]; other site
634177002364	P-class dimer interface [polypeptide binding]; other site
634177002365	active site
634177002366	Cu2+ binding site [ion binding]; other site
634177002367	Zn2+ binding site [ion binding]; other site
634177002368	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
634177002369	GMP synthase; Reviewed; Region: guaA; PRK00074
634177002370	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
634177002371	AMP/PPi binding site [chemical binding]; other site
634177002372	candidate oxyanion hole; other site
634177002373	catalytic triad [active]
634177002374	potential glutamine specificity residues [chemical binding]; other site
634177002375	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
634177002376	ATP Binding subdomain [chemical binding]; other site
634177002377	Ligand Binding sites [chemical binding]; other site
634177002378	Dimerization subdomain; other site
634177002379	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
634177002380	nudix motif; other site
634177002381	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177002382	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634177002383	active site
634177002384	phosphorylation site [posttranslational modification]
634177002385	intermolecular recognition site; other site
634177002386	dimerization interface [polypeptide binding]; other site
634177002387	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
634177002388	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
634177002389	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
634177002390	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
634177002391	putative DNA binding site [nucleotide binding]; other site
634177002392	putative Zn2+ binding site [ion binding]; other site
634177002393	AsnC family; Region: AsnC_trans_reg; pfam01037
634177002394	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
634177002395	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177002396	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634177002397	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177002398	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177002399	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
634177002400	dimerization interface [polypeptide binding]; other site
634177002401	Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836
634177002402	dimer interface [polypeptide binding]; other site
634177002403	DNA binding site [nucleotide binding]
634177002404	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
634177002405	tandem repeat interface [polypeptide binding]; other site
634177002406	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
634177002407	oligomer interface [polypeptide binding]; other site
634177002408	active site residues [active]
634177002409	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
634177002410	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
634177002411	dimerization interface [polypeptide binding]; other site
634177002412	putative DNA binding site [nucleotide binding]; other site
634177002413	putative Zn2+ binding site [ion binding]; other site
634177002414	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
634177002415	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
634177002416	Fe-S cluster binding site [ion binding]; other site
634177002417	active site
634177002418	Fusaric acid resistance protein-like; Region: FUSC_2; cl19401
634177002419	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634177002420	guanine deaminase; Provisional; Region: PRK09228
634177002421	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634177002422	active site
634177002423	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
634177002424	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
634177002425	GTPase CgtA; Reviewed; Region: obgE; PRK12299
634177002426	GTP1/OBG; Region: GTP1_OBG; pfam01018
634177002427	Obg GTPase; Region: Obg; cd01898
634177002428	G1 box; other site
634177002429	GTP/Mg2+ binding site [chemical binding]; other site
634177002430	Switch I region; other site
634177002431	G2 box; other site
634177002432	G3 box; other site
634177002433	Switch II region; other site
634177002434	G4 box; other site
634177002435	G5 box; other site
634177002436	gamma-glutamyl kinase; Provisional; Region: PRK05429
634177002437	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
634177002438	nucleotide binding site [chemical binding]; other site
634177002439	homotetrameric interface [polypeptide binding]; other site
634177002440	putative phosphate binding site [ion binding]; other site
634177002441	putative allosteric binding site; other site
634177002442	PUA domain; Region: PUA; pfam01472
634177002443	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
634177002444	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
634177002445	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
634177002446	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
634177002447	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
634177002448	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
634177002449	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
634177002450	cell division protein MraZ; Reviewed; Region: PRK00326
634177002451	MraZ protein; Region: MraZ; pfam02381
634177002452	MraZ protein; Region: MraZ; pfam02381
634177002453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177002454	S-adenosylmethionine binding site [chemical binding]; other site
634177002455	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
634177002456	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
634177002457	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
634177002458	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
634177002459	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
634177002460	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
634177002461	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
634177002462	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
634177002463	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
634177002464	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
634177002465	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
634177002466	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
634177002467	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
634177002468	Mg++ binding site [ion binding]; other site
634177002469	putative catalytic motif [active]
634177002470	putative substrate binding site [chemical binding]; other site
634177002471	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
634177002472	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
634177002473	cell division protein FtsW; Region: ftsW; TIGR02614
634177002474	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
634177002475	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
634177002476	active site
634177002477	homodimer interface [polypeptide binding]; other site
634177002478	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
634177002479	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
634177002480	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
634177002481	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
634177002482	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
634177002483	FAD binding domain; Region: FAD_binding_4; pfam01565
634177002484	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
634177002485	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
634177002486	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
634177002487	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634177002488	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
634177002489	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
634177002490	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
634177002491	Cell division protein FtsQ; Region: FtsQ; pfam03799
634177002492	cell division protein FtsA; Region: ftsA; TIGR01174
634177002493	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
634177002494	nucleotide binding site [chemical binding]; other site
634177002495	Cell division protein FtsA; Region: FtsA; pfam14450
634177002496	cell division protein FtsZ; Validated; Region: PRK09330
634177002497	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
634177002498	nucleotide binding site [chemical binding]; other site
634177002499	SulA interaction site; other site
634177002500	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
634177002501	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
634177002502	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
634177002503	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
634177002504	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
634177002505	Walker A/P-loop; other site
634177002506	ATP binding site [chemical binding]; other site
634177002507	Q-loop/lid; other site
634177002508	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
634177002509	ABC transporter signature motif; other site
634177002510	Walker B; other site
634177002511	D-loop; other site
634177002512	H-loop/switch region; other site
634177002513	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
634177002514	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
634177002515	nucleotide binding pocket [chemical binding]; other site
634177002516	K-X-D-G motif; other site
634177002517	catalytic site [active]
634177002518	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
634177002519	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
634177002520	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
634177002521	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
634177002522	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
634177002523	Dimer interface [polypeptide binding]; other site
634177002524	BRCT sequence motif; other site
634177002525	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
634177002526	putative ligand binding site [chemical binding]; other site
634177002527	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
634177002528	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
634177002529	Walker A/P-loop; other site
634177002530	ATP binding site [chemical binding]; other site
634177002531	Q-loop/lid; other site
634177002532	ABC transporter signature motif; other site
634177002533	Walker B; other site
634177002534	D-loop; other site
634177002535	H-loop/switch region; other site
634177002536	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
634177002537	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
634177002538	TM-ABC transporter signature motif; other site
634177002539	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
634177002540	TM-ABC transporter signature motif; other site
634177002541	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
634177002542	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
634177002543	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
634177002544	Superinfection immunity protein; Region: Imm_superinfect; pfam14373
634177002545	Domain of unknown function (DUF336); Region: DUF336; cl01249
634177002546	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177002547	H+ Antiporter protein; Region: 2A0121; TIGR00900
634177002548	putative substrate translocation pore; other site
634177002549	The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320
634177002550	putative tRNA-binding site [nucleotide binding]; other site
634177002551	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634177002552	active site
634177002553	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
634177002554	Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544
634177002555	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634177002556	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
634177002557	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
634177002558	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
634177002559	O-Antigen ligase; Region: Wzy_C; pfam04932
634177002560	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634177002561	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634177002562	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634177002563	catalytic residue [active]
634177002564	Sporulation related domain; Region: SPOR; pfam05036
634177002565	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634177002566	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
634177002567	Methyltransferase domain; Region: Methyltransf_26; pfam13659
634177002568	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
634177002569	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
634177002570	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
634177002571	DXD motif; other site
634177002572	PilZ domain; Region: PilZ; pfam07238
634177002573	Bacterial cellulose synthase subunit; Region: BcsB; pfam03170
634177002574	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
634177002575	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634177002576	ATP binding site [chemical binding]; other site
634177002577	Mg++ binding site [ion binding]; other site
634177002578	motif III; other site
634177002579	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634177002580	nucleotide binding region [chemical binding]; other site
634177002581	ATP-binding site [chemical binding]; other site
634177002582	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177002583	S-adenosylmethionine binding site [chemical binding]; other site
634177002584	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
634177002585	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
634177002586	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
634177002587	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
634177002588	putative active site [active]
634177002589	putative PHP Thumb interface [polypeptide binding]; other site
634177002590	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
634177002591	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
634177002592	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
634177002593	generic binding surface II; other site
634177002594	generic binding surface I; other site
634177002595	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
634177002596	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
634177002597	Walker A/P-loop; other site
634177002598	ATP binding site [chemical binding]; other site
634177002599	Q-loop/lid; other site
634177002600	ABC transporter signature motif; other site
634177002601	Walker B; other site
634177002602	D-loop; other site
634177002603	H-loop/switch region; other site
634177002604	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
634177002605	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
634177002606	FtsX-like permease family; Region: FtsX; pfam02687
634177002607	prolyl-tRNA synthetase; Provisional; Region: PRK12325
634177002608	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
634177002609	dimer interface [polypeptide binding]; other site
634177002610	motif 1; other site
634177002611	active site
634177002612	motif 2; other site
634177002613	motif 3; other site
634177002614	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
634177002615	anticodon binding site; other site
634177002616	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
634177002617	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
634177002618	RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521
634177002619	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
634177002620	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
634177002621	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
634177002622	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
634177002623	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
634177002624	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
634177002625	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
634177002626	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
634177002627	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
634177002628	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
634177002629	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
634177002630	4Fe-4S binding domain; Region: Fer4; pfam00037
634177002631	4Fe-4S binding domain; Region: Fer4; pfam00037
634177002632	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
634177002633	NADH dehydrogenase subunit G; Validated; Region: PRK09130
634177002634	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634177002635	catalytic loop [active]
634177002636	iron binding site [ion binding]; other site
634177002637	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
634177002638	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
634177002639	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
634177002640	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
634177002641	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
634177002642	SLBB domain; Region: SLBB; pfam10531
634177002643	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
634177002644	Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257
634177002645	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
634177002646	putative dimer interface [polypeptide binding]; other site
634177002647	[2Fe-2S] cluster binding site [ion binding]; other site
634177002648	NADH dehydrogenase subunit D; Validated; Region: PRK06075
634177002649	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
634177002650	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
634177002651	NADH dehydrogenase subunit B; Validated; Region: PRK06411
634177002652	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
634177002653	histone-like DNA-binding protein HU; Region: HU; cd13831
634177002654	dimer interface [polypeptide binding]; other site
634177002655	DNA binding site [nucleotide binding]
634177002656	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
634177002657	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
634177002658	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177002659	Walker A motif; other site
634177002660	ATP binding site [chemical binding]; other site
634177002661	Walker B motif; other site
634177002662	arginine finger; other site
634177002663	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
634177002664	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
634177002665	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
634177002666	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177002667	Walker A motif; other site
634177002668	ATP binding site [chemical binding]; other site
634177002669	Walker B motif; other site
634177002670	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
634177002671	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
634177002672	oligomer interface [polypeptide binding]; other site
634177002673	active site residues [active]
634177002674	trigger factor; Provisional; Region: tig; PRK01490
634177002675	Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697
634177002676	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
634177002677	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
634177002678	Uncharacterized conserved protein [Function unknown]; Region: COG0062
634177002679	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
634177002680	putative substrate binding site [chemical binding]; other site
634177002681	putative ATP binding site [chemical binding]; other site
634177002682	Predicted integral membrane protein [Function unknown]; Region: COG5615
634177002683	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
634177002684	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
634177002685	ATP binding site [chemical binding]; other site
634177002686	Mg++ binding site [ion binding]; other site
634177002687	motif III; other site
634177002688	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634177002689	nucleotide binding region [chemical binding]; other site
634177002690	ATP-binding site [chemical binding]; other site
634177002691	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
634177002692	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
634177002693	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
634177002694	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
634177002695	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
634177002696	trimerization site [polypeptide binding]; other site
634177002697	active site
634177002698	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
634177002699	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634177002700	catalytic residue [active]
634177002701	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
634177002702	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
634177002703	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
634177002704	FeS assembly ATPase SufC; Region: sufC; TIGR01978
634177002705	Walker A/P-loop; other site
634177002706	ATP binding site [chemical binding]; other site
634177002707	Q-loop/lid; other site
634177002708	ABC transporter signature motif; other site
634177002709	Walker B; other site
634177002710	D-loop; other site
634177002711	H-loop/switch region; other site
634177002712	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
634177002713	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
634177002714	Transcriptional regulator; Region: Rrf2; cl17282
634177002715	Rrf2 family protein; Region: rrf2_super; TIGR00738
634177002716	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827
634177002717	Protein of unknown function (DUF445); Region: DUF445; pfam04286
634177002718	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
634177002719	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
634177002720	elongation factor G; Reviewed; Region: PRK12739
634177002721	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
634177002722	G1 box; other site
634177002723	putative GEF interaction site [polypeptide binding]; other site
634177002724	GTP/Mg2+ binding site [chemical binding]; other site
634177002725	Switch I region; other site
634177002726	G2 box; other site
634177002727	G3 box; other site
634177002728	Switch II region; other site
634177002729	G4 box; other site
634177002730	G5 box; other site
634177002731	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
634177002732	Elongation Factor G, domain II; Region: EFG_II; pfam14492
634177002733	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
634177002734	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
634177002735	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
634177002736	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634177002737	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
634177002738	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
634177002739	Walker A/P-loop; other site
634177002740	ATP binding site [chemical binding]; other site
634177002741	Q-loop/lid; other site
634177002742	ABC transporter signature motif; other site
634177002743	Walker B; other site
634177002744	D-loop; other site
634177002745	H-loop/switch region; other site
634177002746	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
634177002747	nudix motif; other site
634177002748	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
634177002749	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
634177002750	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
634177002751	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
634177002752	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
634177002753	DNA binding residues [nucleotide binding]
634177002754	Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835
634177002755	DNA binding site [nucleotide binding]
634177002756	dimer interface [polypeptide binding]; other site
634177002757	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
634177002758	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
634177002759	dimer interface [polypeptide binding]; other site
634177002760	active site
634177002761	CoA binding pocket [chemical binding]; other site
634177002762	putative phosphate acyltransferase; Provisional; Region: PRK05331
634177002763	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
634177002764	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
634177002765	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634177002766	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634177002767	dimer interface [polypeptide binding]; other site
634177002768	phosphorylation site [posttranslational modification]
634177002769	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177002770	ATP binding site [chemical binding]; other site
634177002771	Mg2+ binding site [ion binding]; other site
634177002772	G-X-G motif; other site
634177002773	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
634177002774	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
634177002775	active site
634177002776	catalytic residues [active]
634177002777	metal binding site [ion binding]; metal-binding site
634177002778	Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382
634177002779	Transcriptional regulators [Transcription]; Region: MarR; COG1846
634177002780	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
634177002781	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
634177002782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177002783	active site
634177002784	phosphorylation site [posttranslational modification]
634177002785	intermolecular recognition site; other site
634177002786	dimerization interface [polypeptide binding]; other site
634177002787	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634177002788	DNA binding site [nucleotide binding]
634177002789	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
634177002790	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
634177002791	substrate binding site [chemical binding]; other site
634177002792	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
634177002793	substrate binding site [chemical binding]; other site
634177002794	ligand binding site [chemical binding]; other site
634177002795	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
634177002796	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
634177002797	RimM N-terminal domain; Region: RimM; pfam01782
634177002798	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
634177002799	PRC-barrel domain; Region: PRC; pfam05239
634177002800	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
634177002801	signal recognition particle protein; Provisional; Region: PRK10867
634177002802	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
634177002803	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
634177002804	Signal peptide binding domain; Region: SRP_SPB; pfam02978
634177002805	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
634177002806	dimer interface [polypeptide binding]; other site
634177002807	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
634177002808	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
634177002809	Walker A/P-loop; other site
634177002810	ATP binding site [chemical binding]; other site
634177002811	Q-loop/lid; other site
634177002812	ABC transporter signature motif; other site
634177002813	Walker B; other site
634177002814	D-loop; other site
634177002815	H-loop/switch region; other site
634177002816	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
634177002817	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634177002818	dimer interface [polypeptide binding]; other site
634177002819	conserved gate region; other site
634177002820	putative PBP binding loops; other site
634177002821	ABC-ATPase subunit interface; other site
634177002822	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
634177002823	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634177002824	dimer interface [polypeptide binding]; other site
634177002825	conserved gate region; other site
634177002826	putative PBP binding loops; other site
634177002827	ABC-ATPase subunit interface; other site
634177002828	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
634177002829	active site
634177002830	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
634177002831	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634177002832	dimer interface [polypeptide binding]; other site
634177002833	conserved gate region; other site
634177002834	putative PBP binding loops; other site
634177002835	ABC-ATPase subunit interface; other site
634177002836	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
634177002837	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177002838	Walker A/P-loop; other site
634177002839	ATP binding site [chemical binding]; other site
634177002840	Q-loop/lid; other site
634177002841	ABC transporter signature motif; other site
634177002842	Walker B; other site
634177002843	D-loop; other site
634177002844	H-loop/switch region; other site
634177002845	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
634177002846	RNA/DNA hybrid binding site [nucleotide binding]; other site
634177002847	active site
634177002848	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
634177002849	Phosphotransferase enzyme family; Region: APH; pfam01636
634177002850	putative active site [active]
634177002851	putative substrate binding site [chemical binding]; other site
634177002852	ATP binding site [chemical binding]; other site
634177002853	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944
634177002854	Fe-S cluster binding site [ion binding]; other site
634177002855	substrate binding site [chemical binding]; other site
634177002856	catalytic site [active]
634177002857	Predicted membrane protein [Function unknown]; Region: COG1297
634177002858	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
634177002859	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
634177002860	active site
634177002861	Zn binding site [ion binding]; other site
634177002862	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177002863	S-adenosylmethionine binding site [chemical binding]; other site
634177002864	Protein of unknown function (DUF423); Region: DUF423; cl01008
634177002865	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
634177002866	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
634177002867	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
634177002868	AAA domain; Region: AAA_33; pfam13671
634177002869	ATP-binding site [chemical binding]; other site
634177002870	Gluconate-6-phosphate binding site [chemical binding]; other site
634177002871	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
634177002872	aspartate aminotransferase; Provisional; Region: PRK05764
634177002873	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634177002874	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177002875	homodimer interface [polypeptide binding]; other site
634177002876	catalytic residue [active]
634177002877	aspartate aminotransferase; Provisional; Region: PRK05764
634177002878	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634177002879	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177002880	homodimer interface [polypeptide binding]; other site
634177002881	catalytic residue [active]
634177002882	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634177002883	active site
634177002884	nucleotide binding site [chemical binding]; other site
634177002885	HIGH motif; other site
634177002886	KMSKS motif; other site
634177002887	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
634177002888	active site
634177002889	hopanoid C-3 methylase HpnR; Region: HpnR_B12_rSAM; TIGR04367
634177002890	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
634177002891	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634177002892	FeS/SAM binding site; other site
634177002893	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
634177002894	metal-binding site [ion binding]
634177002895	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
634177002896	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
634177002897	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177002898	Walker A motif; other site
634177002899	ATP binding site [chemical binding]; other site
634177002900	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
634177002901	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
634177002902	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
634177002903	active site
634177002904	HslU subunit interaction site [polypeptide binding]; other site
634177002905	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177002906	active site
634177002907	phosphorylation site [posttranslational modification]
634177002908	intermolecular recognition site; other site
634177002909	dimerization interface [polypeptide binding]; other site
634177002910	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
634177002911	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
634177002912	putative active site [active]
634177002913	heme pocket [chemical binding]; other site
634177002914	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634177002915	dimer interface [polypeptide binding]; other site
634177002916	phosphorylation site [posttranslational modification]
634177002917	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177002918	ATP binding site [chemical binding]; other site
634177002919	Mg2+ binding site [ion binding]; other site
634177002920	G-X-G motif; other site
634177002921	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177002922	active site
634177002923	phosphorylation site [posttranslational modification]
634177002924	intermolecular recognition site; other site
634177002925	dimerization interface [polypeptide binding]; other site
634177002926	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177002927	active site
634177002928	phosphorylation site [posttranslational modification]
634177002929	intermolecular recognition site; other site
634177002930	dimerization interface [polypeptide binding]; other site
634177002931	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078
634177002932	active site
634177002933	phosphorylation site [posttranslational modification]
634177002934	intermolecular recognition site; other site
634177002935	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634177002936	dimerization interface [polypeptide binding]; other site
634177002937	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634177002938	dimer interface [polypeptide binding]; other site
634177002939	phosphorylation site [posttranslational modification]
634177002940	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177002941	ATP binding site [chemical binding]; other site
634177002942	Mg2+ binding site [ion binding]; other site
634177002943	G-X-G motif; other site
634177002944	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
634177002945	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177002946	active site
634177002947	phosphorylation site [posttranslational modification]
634177002948	intermolecular recognition site; other site
634177002949	dimerization interface [polypeptide binding]; other site
634177002950	CheB methylesterase; Region: CheB_methylest; pfam01339
634177002951	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
634177002952	putative binding surface; other site
634177002953	active site
634177002954	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177002955	ATP binding site [chemical binding]; other site
634177002956	Mg2+ binding site [ion binding]; other site
634177002957	G-X-G motif; other site
634177002958	CheW-like domain; Region: CheW; pfam01584
634177002959	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634177002960	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177002961	active site
634177002962	phosphorylation site [posttranslational modification]
634177002963	intermolecular recognition site; other site
634177002964	dimerization interface [polypeptide binding]; other site
634177002965	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
634177002966	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
634177002967	dimerization interface [polypeptide binding]; other site
634177002968	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
634177002969	dimer interface [polypeptide binding]; other site
634177002970	putative CheW interface [polypeptide binding]; other site
634177002971	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
634177002972	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
634177002973	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177002974	S-adenosylmethionine binding site [chemical binding]; other site
634177002975	CheW-like domain; Region: CheW; pfam01584
634177002976	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
634177002977	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177002978	Walker A/P-loop; other site
634177002979	ATP binding site [chemical binding]; other site
634177002980	Q-loop/lid; other site
634177002981	ABC transporter signature motif; other site
634177002982	Walker B; other site
634177002983	D-loop; other site
634177002984	H-loop/switch region; other site
634177002985	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
634177002986	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
634177002987	putative active site [active]
634177002988	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
634177002989	putative acyl-acceptor binding pocket; other site
634177002990	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
634177002991	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
634177002992	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
634177002993	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
634177002994	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
634177002995	Methyltransferase domain; Region: Methyltransf_23; pfam13489
634177002996	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
634177002997	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
634177002998	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
634177002999	CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009
634177003000	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
634177003001	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl19174
634177003002	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
634177003003	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl19689
634177003004	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
634177003005	active site
634177003006	catalytic tetrad [active]
634177003007	DNA polymerase III subunit chi; Validated; Region: PRK05728
634177003008	multifunctional aminopeptidase A; Provisional; Region: PRK00913
634177003009	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
634177003010	interface (dimer of trimers) [polypeptide binding]; other site
634177003011	Substrate-binding/catalytic site; other site
634177003012	Zn-binding sites [ion binding]; other site
634177003013	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
634177003014	active site
634177003015	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
634177003016	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
634177003017	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
634177003018	FAD binding domain; Region: FAD_binding_4; pfam01565
634177003019	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
634177003020	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
634177003021	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
634177003022	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
634177003023	OstA-like protein; Region: OstA; cl00844
634177003024	Organic solvent tolerance protein; Region: OstA_C; pfam04453
634177003025	SurA N-terminal domain; Region: SurA_N; pfam09312
634177003026	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
634177003027	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
634177003028	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
634177003029	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
634177003030	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
634177003031	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
634177003032	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
634177003033	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
634177003034	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634177003035	Coenzyme A binding pocket [chemical binding]; other site
634177003036	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
634177003037	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
634177003038	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
634177003039	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
634177003040	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
634177003041	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
634177003042	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634177003043	DNA binding residues [nucleotide binding]
634177003044	DNA primase, catalytic core; Region: dnaG; TIGR01391
634177003045	CHC2 zinc finger; Region: zf-CHC2; cl17510
634177003046	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
634177003047	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
634177003048	active site
634177003049	metal binding site [ion binding]; metal-binding site
634177003050	interdomain interaction site; other site
634177003051	Yqey-like protein; Region: YqeY; pfam09424
634177003052	DNA-binding transcriptional regulator Cro; Region: P22_Cro; cl18770
634177003053	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
634177003054	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
634177003055	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
634177003056	catalytic site [active]
634177003057	subunit interface [polypeptide binding]; other site
634177003058	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
634177003059	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
634177003060	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634177003061	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
634177003062	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
634177003063	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634177003064	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
634177003065	IMP binding site; other site
634177003066	dimer interface [polypeptide binding]; other site
634177003067	interdomain contacts; other site
634177003068	partial ornithine binding site; other site
634177003069	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
634177003070	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
634177003071	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
634177003072	threonine dehydratase; Provisional; Region: PRK07334
634177003073	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
634177003074	tetramer interface [polypeptide binding]; other site
634177003075	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177003076	catalytic residue [active]
634177003077	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
634177003078	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634177003079	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634177003080	Domain of unknown function (DUF4203); Region: DUF4203; pfam13886
634177003081	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634177003082	active site
634177003083	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177003084	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
634177003085	putative substrate translocation pore; other site
634177003086	Uncharacterized conserved protein [Function unknown]; Region: COG0398
634177003087	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
634177003088	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158
634177003089	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634177003090	active site
634177003091	SelR domain; Region: SelR; cl15841
634177003092	phosphoglyceromutase; Provisional; Region: PRK05434
634177003093	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
634177003094	Peptidase family M23; Region: Peptidase_M23; pfam01551
634177003095	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
634177003096	C-terminal peptidase (prc); Region: prc; TIGR00225
634177003097	Catalytic dyad [active]
634177003098	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
634177003099	putative active site [active]
634177003100	Ap4A binding site [chemical binding]; other site
634177003101	nudix motif; other site
634177003102	putative metal binding site [ion binding]; other site
634177003103	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
634177003104	nudix motif; other site
634177003105	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
634177003106	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177003107	putative substrate translocation pore; other site
634177003108	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
634177003109	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
634177003110	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634177003111	HlyD family secretion protein; Region: HlyD_3; pfam13437
634177003112	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
634177003113	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634177003114	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177003115	Walker A/P-loop; other site
634177003116	ATP binding site [chemical binding]; other site
634177003117	Q-loop/lid; other site
634177003118	ABC transporter signature motif; other site
634177003119	Walker B; other site
634177003120	D-loop; other site
634177003121	H-loop/switch region; other site
634177003122	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
634177003123	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
634177003124	active site
634177003125	NTP binding site [chemical binding]; other site
634177003126	metal binding triad [ion binding]; metal-binding site
634177003127	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
634177003128	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
634177003129	MoxR-like ATPases [General function prediction only]; Region: COG0714
634177003130	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177003131	Walker A motif; other site
634177003132	ATP binding site [chemical binding]; other site
634177003133	Walker B motif; other site
634177003134	arginine finger; other site
634177003135	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
634177003136	Protein of unknown function DUF58; Region: DUF58; pfam01882
634177003137	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
634177003138	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
634177003139	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
634177003140	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
634177003141	metal ion-dependent adhesion site (MIDAS); other site
634177003142	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
634177003143	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
634177003144	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
634177003145	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
634177003146	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
634177003147	Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
634177003148	RNA/DNA hybrid binding site [nucleotide binding]; other site
634177003149	active site
634177003150	CsbD-like; Region: CsbD; pfam05532
634177003151	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
634177003152	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177003153	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634177003154	putative substrate translocation pore; other site
634177003155	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
634177003156	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634177003157	HlyD family secretion protein; Region: HlyD_3; pfam13437
634177003158	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
634177003159	MMPL family; Region: MMPL; cl14618
634177003160	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
634177003161	MMPL family; Region: MMPL; cl14618
634177003162	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634177003163	Outer membrane efflux protein; Region: OEP; pfam02321
634177003164	Outer membrane efflux protein; Region: OEP; pfam02321
634177003165	hypothetical protein; Provisional; Region: PRK13682
634177003166	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
634177003167	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
634177003168	Walker A/P-loop; other site
634177003169	ATP binding site [chemical binding]; other site
634177003170	Q-loop/lid; other site
634177003171	ABC transporter signature motif; other site
634177003172	Walker B; other site
634177003173	D-loop; other site
634177003174	H-loop/switch region; other site
634177003175	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
634177003176	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634177003177	dimer interface [polypeptide binding]; other site
634177003178	conserved gate region; other site
634177003179	putative PBP binding loops; other site
634177003180	ABC-ATPase subunit interface; other site
634177003181	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
634177003182	NMT1-like family; Region: NMT1_2; cl17432
634177003183	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
634177003184	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
634177003185	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
634177003186	alphaNTD - beta interaction site [polypeptide binding]; other site
634177003187	alphaNTD homodimer interface [polypeptide binding]; other site
634177003188	alphaNTD - beta' interaction site [polypeptide binding]; other site
634177003189	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
634177003190	30S ribosomal protein S11; Validated; Region: PRK05309
634177003191	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
634177003192	adenylate kinase; Reviewed; Region: adk; PRK00279
634177003193	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
634177003194	AMP-binding site [chemical binding]; other site
634177003195	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
634177003196	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
634177003197	SecY translocase; Region: SecY; pfam00344
634177003198	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
634177003199	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
634177003200	23S rRNA binding site [nucleotide binding]; other site
634177003201	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
634177003202	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
634177003203	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
634177003204	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
634177003205	5S rRNA interface [nucleotide binding]; other site
634177003206	23S rRNA interface [nucleotide binding]; other site
634177003207	L5 interface [polypeptide binding]; other site
634177003208	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
634177003209	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
634177003210	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
634177003211	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
634177003212	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
634177003213	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
634177003214	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
634177003215	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
634177003216	RNA binding site [nucleotide binding]; other site
634177003217	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
634177003218	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
634177003219	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
634177003220	23S rRNA interface [nucleotide binding]; other site
634177003221	putative translocon interaction site; other site
634177003222	signal recognition particle (SRP54) interaction site; other site
634177003223	L23 interface [polypeptide binding]; other site
634177003224	trigger factor interaction site; other site
634177003225	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
634177003226	23S rRNA interface [nucleotide binding]; other site
634177003227	5S rRNA interface [nucleotide binding]; other site
634177003228	putative antibiotic binding site [chemical binding]; other site
634177003229	L25 interface [polypeptide binding]; other site
634177003230	L27 interface [polypeptide binding]; other site
634177003231	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
634177003232	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
634177003233	G-X-X-G motif; other site
634177003234	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
634177003235	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
634177003236	putative translocon binding site; other site
634177003237	protein-rRNA interface [nucleotide binding]; other site
634177003238	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
634177003239	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
634177003240	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
634177003241	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
634177003242	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
634177003243	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
634177003244	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
634177003245	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
634177003246	elongation factor Tu; Reviewed; Region: PRK00049
634177003247	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
634177003248	G1 box; other site
634177003249	GEF interaction site [polypeptide binding]; other site
634177003250	GTP/Mg2+ binding site [chemical binding]; other site
634177003251	Switch I region; other site
634177003252	G2 box; other site
634177003253	G3 box; other site
634177003254	Switch II region; other site
634177003255	G4 box; other site
634177003256	G5 box; other site
634177003257	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
634177003258	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
634177003259	Antibiotic Binding Site [chemical binding]; other site
634177003260	30S ribosomal protein S7; Validated; Region: PRK05302
634177003261	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
634177003262	S17 interaction site [polypeptide binding]; other site
634177003263	S8 interaction site; other site
634177003264	16S rRNA interaction site [nucleotide binding]; other site
634177003265	streptomycin interaction site [chemical binding]; other site
634177003266	23S rRNA interaction site [nucleotide binding]; other site
634177003267	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
634177003268	Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609
634177003269	beta and beta' interface [polypeptide binding]; other site
634177003270	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
634177003271	beta' and sigma factor interface [polypeptide binding]; other site
634177003272	Zn-binding [ion binding]; other site
634177003273	active site region [active]
634177003274	catalytic site [active]
634177003275	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
634177003276	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
634177003277	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
634177003278	G-loop; other site
634177003279	DNA binding site [nucleotide binding]
634177003280	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
634177003281	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
634177003282	RPB12 interaction site [polypeptide binding]; other site
634177003283	RPB1 interaction site [polypeptide binding]; other site
634177003284	RPB10 interaction site [polypeptide binding]; other site
634177003285	RPB11 interaction site [polypeptide binding]; other site
634177003286	RPB3 interaction site [polypeptide binding]; other site
634177003287	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
634177003288	core dimer interface [polypeptide binding]; other site
634177003289	peripheral dimer interface [polypeptide binding]; other site
634177003290	L10 interface [polypeptide binding]; other site
634177003291	L11 interface [polypeptide binding]; other site
634177003292	putative EF-Tu interaction site [polypeptide binding]; other site
634177003293	putative EF-G interaction site [polypeptide binding]; other site
634177003294	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
634177003295	23S rRNA interface [nucleotide binding]; other site
634177003296	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
634177003297	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
634177003298	mRNA/rRNA interface [nucleotide binding]; other site
634177003299	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
634177003300	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
634177003301	23S rRNA interface [nucleotide binding]; other site
634177003302	L7/L12 interface [polypeptide binding]; other site
634177003303	putative thiostrepton binding site; other site
634177003304	L25 interface [polypeptide binding]; other site
634177003305	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634177003306	Outer membrane efflux protein; Region: OEP; pfam02321
634177003307	Outer membrane efflux protein; Region: OEP; pfam02321
634177003308	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
634177003309	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
634177003310	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
634177003311	NOPS domain, including C-terminal helical extension region, in the p54nrb/PSF/PSP1 family; Region: eNOPS_SF; cl06904
634177003312	HlyD family secretion protein; Region: HlyD_3; pfam13437
634177003313	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
634177003314	MMPL family; Region: MMPL; cl14618
634177003315	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
634177003316	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
634177003317	dimerization interface [polypeptide binding]; other site
634177003318	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634177003319	dimer interface [polypeptide binding]; other site
634177003320	phosphorylation site [posttranslational modification]
634177003321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177003322	ATP binding site [chemical binding]; other site
634177003323	Mg2+ binding site [ion binding]; other site
634177003324	G-X-G motif; other site
634177003325	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634177003326	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177003327	active site
634177003328	phosphorylation site [posttranslational modification]
634177003329	intermolecular recognition site; other site
634177003330	dimerization interface [polypeptide binding]; other site
634177003331	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634177003332	DNA binding site [nucleotide binding]
634177003333	RmuC family; Region: RmuC; pfam02646
634177003334	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
634177003335	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
634177003336	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177003337	putative substrate translocation pore; other site
634177003338	Protein of unknown function; Region: DUF3971; pfam13116
634177003339	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
634177003340	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
634177003341	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
634177003342	metal binding triad; other site
634177003343	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
634177003344	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
634177003345	metal binding triad; other site
634177003346	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627
634177003347	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
634177003348	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
634177003349	catalytic triad [active]
634177003350	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
634177003351	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
634177003352	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
634177003353	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
634177003354	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
634177003355	dimerization interface [polypeptide binding]; other site
634177003356	ligand binding site [chemical binding]; other site
634177003357	NADP binding site [chemical binding]; other site
634177003358	catalytic site [active]
634177003359	EcsC protein family; Region: EcsC; pfam12787
634177003360	EVE domain; Region: EVE; pfam01878
634177003361	YciI-like protein; Reviewed; Region: PRK12863
634177003362	heme exporter protein CcmC; Region: ccmC; TIGR01191
634177003363	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
634177003364	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
634177003365	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
634177003366	catalytic residues [active]
634177003367	central insert; other site
634177003368	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
634177003369	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
634177003370	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
634177003371	Beta-lactamase; Region: Beta-lactamase; pfam00144
634177003372	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
634177003373	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
634177003374	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
634177003375	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
634177003376	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
634177003377	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
634177003378	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
634177003379	RNA binding site [nucleotide binding]; other site
634177003380	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
634177003381	RNA binding site [nucleotide binding]; other site
634177003382	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
634177003383	RNA binding site [nucleotide binding]; other site
634177003384	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
634177003385	RNA binding site [nucleotide binding]; other site
634177003386	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
634177003387	RNA binding site [nucleotide binding]; other site
634177003388	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
634177003389	RNA binding site [nucleotide binding]; other site
634177003390	cytidylate kinase; Provisional; Region: cmk; PRK00023
634177003391	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
634177003392	CMP-binding site; other site
634177003393	The sites determining sugar specificity; other site
634177003394	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
634177003395	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
634177003396	hinge; other site
634177003397	active site
634177003398	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
634177003399	Dihydroneopterin aldolase; Region: FolB; smart00905
634177003400	active site
634177003401	short chain dehydrogenase; Provisional; Region: PRK09134
634177003402	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177003403	NAD(P) binding site [chemical binding]; other site
634177003404	active site
634177003405	recombination protein RecR; Reviewed; Region: recR; PRK00076
634177003406	RecR protein; Region: RecR; pfam02132
634177003407	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
634177003408	putative active site [active]
634177003409	putative metal-binding site [ion binding]; other site
634177003410	tetramer interface [polypeptide binding]; other site
634177003411	hypothetical protein; Validated; Region: PRK00153
634177003412	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
634177003413	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177003414	Walker A motif; other site
634177003415	ATP binding site [chemical binding]; other site
634177003416	Walker B motif; other site
634177003417	arginine finger; other site
634177003418	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
634177003419	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
634177003420	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
634177003421	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
634177003422	active site
634177003423	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
634177003424	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
634177003425	Uncharacterized conserved protein [Function unknown]; Region: COG2127
634177003426	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
634177003427	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177003428	Walker A motif; other site
634177003429	ATP binding site [chemical binding]; other site
634177003430	Walker B motif; other site
634177003431	arginine finger; other site
634177003432	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177003433	Walker A motif; other site
634177003434	ATP binding site [chemical binding]; other site
634177003435	Walker B motif; other site
634177003436	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
634177003437	Uncharacterized conserved protein [Function unknown]; Region: COG1742
634177003438	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
634177003439	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
634177003440	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177003441	malonic semialdehyde reductase; Provisional; Region: PRK10538
634177003442	NAD(P) binding site [chemical binding]; other site
634177003443	active site
634177003444	hypothetical protein; Validated; Region: PRK00228
634177003445	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
634177003446	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
634177003447	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634177003448	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
634177003449	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
634177003450	quinone interaction residues [chemical binding]; other site
634177003451	active site
634177003452	catalytic residues [active]
634177003453	FMN binding site [chemical binding]; other site
634177003454	substrate binding site [chemical binding]; other site
634177003455	Major royal jelly protein; Region: MRJP; pfam03022
634177003456	Cytochrome c; Region: Cytochrom_C; pfam00034
634177003457	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634177003458	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634177003459	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
634177003460	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
634177003461	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177003462	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177003463	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
634177003464	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
634177003465	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
634177003466	cobyric acid synthase; Provisional; Region: PRK00784
634177003467	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
634177003468	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
634177003469	catalytic triad [active]
634177003470	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
634177003471	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
634177003472	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
634177003473	homodimer interface [polypeptide binding]; other site
634177003474	Walker A motif; other site
634177003475	ATP binding site [chemical binding]; other site
634177003476	hydroxycobalamin binding site [chemical binding]; other site
634177003477	Walker B motif; other site
634177003478	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
634177003479	homotrimer interface [polypeptide binding]; other site
634177003480	Walker A motif; other site
634177003481	GTP binding site [chemical binding]; other site
634177003482	Walker B motif; other site
634177003483	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
634177003484	putative dimer interface [polypeptide binding]; other site
634177003485	active site pocket [active]
634177003486	putative cataytic base [active]
634177003487	cobalamin synthase; Reviewed; Region: cobS; PRK00235
634177003488	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634177003489	catalytic core [active]
634177003490	L-asparagine permease; Provisional; Region: PRK15049
634177003491	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
634177003492	active site
634177003493	homotetramer interface [polypeptide binding]; other site
634177003494	homodimer interface [polypeptide binding]; other site
634177003495	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
634177003496	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
634177003497	active site
634177003498	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
634177003499	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177003500	putative substrate translocation pore; other site
634177003501	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
634177003502	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
634177003503	dimer interface [polypeptide binding]; other site
634177003504	PYR/PP interface [polypeptide binding]; other site
634177003505	TPP binding site [chemical binding]; other site
634177003506	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634177003507	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
634177003508	TPP-binding site [chemical binding]; other site
634177003509	dimer interface [polypeptide binding]; other site
634177003510	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
634177003511	pyruvate phosphate dikinase; Provisional; Region: PRK09279
634177003512	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
634177003513	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
634177003514	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
634177003515	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
634177003516	Na binding site [ion binding]; other site
634177003517	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
634177003518	Transcriptional regulator; Region: Rrf2; cl17282
634177003519	Rrf2 family protein; Region: rrf2_super; TIGR00738
634177003520	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
634177003521	NAD(P) binding site [chemical binding]; other site
634177003522	catalytic residues [active]
634177003523	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
634177003524	active site
634177003525	Cytochrome c; Region: Cytochrom_C; pfam00034
634177003526	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634177003527	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634177003528	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
634177003529	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
634177003530	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
634177003531	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177003532	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
634177003533	Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318
634177003534	Iron permease FTR1 family; Region: FTR1; cl00475
634177003535	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
634177003536	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
634177003537	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634177003538	ABC transporter; Region: ABC_tran_2; pfam12848
634177003539	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634177003540	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
634177003541	metal-binding site [ion binding]
634177003542	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
634177003543	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
634177003544	metal-binding site [ion binding]
634177003545	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
634177003546	Soluble P-type ATPase [General function prediction only]; Region: COG4087
634177003547	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
634177003548	putative homodimer interface [polypeptide binding]; other site
634177003549	putative homotetramer interface [polypeptide binding]; other site
634177003550	putative allosteric switch controlling residues; other site
634177003551	putative metal binding site [ion binding]; other site
634177003552	putative homodimer-homodimer interface [polypeptide binding]; other site
634177003553	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
634177003554	Cupredoxin superfamily; Region: Cupredoxin; cl19115
634177003555	The second cupredoxin domain of  CopA copper resistance protein family; Region: CuRO_2_CopA; cd13874
634177003556	putative Domain 1 interface [polypeptide binding]; other site
634177003557	putative Domain 3 interface [polypeptide binding]; other site
634177003558	The third cupredoxin domain of CopA copper resistance protein family; Region: CuRO_3_CopA; cd13896
634177003559	putative Domain 2 interface [polypeptide binding]; other site
634177003560	Type 1 (T1) Cu binding site [ion binding]; other site
634177003561	putative Domain 1 interface [polypeptide binding]; other site
634177003562	trinuclear Cu binding site [ion binding]; other site
634177003563	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
634177003564	glutathionine S-transferase; Provisional; Region: PRK10542
634177003565	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
634177003566	C-terminal domain interface [polypeptide binding]; other site
634177003567	GSH binding site (G-site) [chemical binding]; other site
634177003568	dimer interface [polypeptide binding]; other site
634177003569	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
634177003570	dimer interface [polypeptide binding]; other site
634177003571	N-terminal domain interface [polypeptide binding]; other site
634177003572	substrate binding pocket (H-site) [chemical binding]; other site
634177003573	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
634177003574	potential frameshift: common BLAST hit: gi|209543634|ref|YP_002275863.1| membrane-bound PQQ-dependent dehydrogenase
634177003575	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
634177003576	potential frameshift: common BLAST hit: gi|209543634|ref|YP_002275863.1| membrane-bound PQQ-dependent dehydrogenase
634177003577	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
634177003578	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
634177003579	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634177003580	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559
634177003581	NAD(P) binding site [chemical binding]; other site
634177003582	catalytic residues [active]
634177003583	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
634177003584	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
634177003585	iron-sulfur cluster [ion binding]; other site
634177003586	[2Fe-2S] cluster binding site [ion binding]; other site
634177003587	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
634177003588	hydrophobic ligand binding site; other site
634177003589	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177003590	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177003591	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
634177003592	dimerization interface [polypeptide binding]; other site
634177003593	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
634177003594	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
634177003595	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
634177003596	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
634177003597	ligand binding site [chemical binding]; other site
634177003598	flexible hinge region; other site
634177003599	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
634177003600	non-specific DNA interactions [nucleotide binding]; other site
634177003601	DNA binding site [nucleotide binding]
634177003602	sequence specific DNA binding site [nucleotide binding]; other site
634177003603	putative cAMP binding site [chemical binding]; other site
634177003604	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634177003605	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634177003606	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
634177003607	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177003608	putative substrate translocation pore; other site
634177003609	Domain of unknown function (DUF336); Region: DUF336; cl01249
634177003610	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
634177003611	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177003612	NAD(P) binding site [chemical binding]; other site
634177003613	active site
634177003614	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634177003615	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634177003616	non-specific DNA binding site [nucleotide binding]; other site
634177003617	salt bridge; other site
634177003618	sequence-specific DNA binding site [nucleotide binding]; other site
634177003619	Hint domain; Region: Hint_2; pfam13403
634177003620	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
634177003621	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
634177003622	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
634177003623	putative NAD(P) binding site [chemical binding]; other site
634177003624	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
634177003625	Ligand Binding Site [chemical binding]; other site
634177003626	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
634177003627	Ligand Binding Site [chemical binding]; other site
634177003628	CrcB-like protein; Region: CRCB; cl09114
634177003629	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
634177003630	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634177003631	N-terminal plug; other site
634177003632	ligand-binding site [chemical binding]; other site
634177003633	Transposase domain (DUF772); Region: DUF772; pfam05598
634177003634	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177003635	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177003636	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177003637	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177003638	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
634177003639	putative dimerization interface [polypeptide binding]; other site
634177003640	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177003641	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177003642	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177003643	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177003644	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634177003645	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177003646	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177003647	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177003648	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177003649	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
634177003650	Transposase; Region: DEDD_Tnp_IS110; pfam01548
634177003651	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
634177003652	Transposase; Region: HTH_Tnp_1; pfam01527
634177003653	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
634177003654	substrate binding site [chemical binding]; other site
634177003655	THF binding site; other site
634177003656	zinc-binding site [ion binding]; other site
634177003657	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
634177003658	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
634177003659	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
634177003660	[2Fe-2S] cluster binding site [ion binding]; other site
634177003661	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
634177003662	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
634177003663	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
634177003664	Walker A/P-loop; other site
634177003665	ATP binding site [chemical binding]; other site
634177003666	Q-loop/lid; other site
634177003667	ABC transporter signature motif; other site
634177003668	Walker B; other site
634177003669	D-loop; other site
634177003670	H-loop/switch region; other site
634177003671	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
634177003672	ABC-ATPase subunit  interface; other site
634177003673	dimer interface [polypeptide binding]; other site
634177003674	putative PBP binding regions; other site
634177003675	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
634177003676	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
634177003677	intersubunit interface [polypeptide binding]; other site
634177003678	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
634177003679	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634177003680	N-terminal plug; other site
634177003681	ligand-binding site [chemical binding]; other site
634177003682	cobyric acid synthase; Provisional; Region: PRK00784
634177003683	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
634177003684	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
634177003685	catalytic triad [active]
634177003686	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
634177003687	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
634177003688	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634177003689	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634177003690	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177003691	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177003692	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177003693	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177003694	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634177003695	GntP family permease; Region: GntP_permease; pfam02447
634177003696	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
634177003697	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
634177003698	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
634177003699	NADP binding site [chemical binding]; other site
634177003700	homodimer interface [polypeptide binding]; other site
634177003701	active site
634177003702	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
634177003703	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
634177003704	putative NAD(P) binding site [chemical binding]; other site
634177003705	catalytic Zn binding site [ion binding]; other site
634177003706	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177003707	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
634177003708	AAA domain; Region: AAA_33; pfam13671
634177003709	ATP-binding site [chemical binding]; other site
634177003710	Walker A/P-loop; other site
634177003711	Gluconate-6-phosphate binding site [chemical binding]; other site
634177003712	ATP binding site [chemical binding]; other site
634177003713	Integrase core domain; Region: rve; pfam00665
634177003714	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
634177003715	Integrase core domain; Region: rve_3; pfam13683
634177003716	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
634177003717	Transposase, Mutator family; Region: Transposase_mut; cl19537
634177003718	Transposase, Mutator family; Region: Transposase_mut; pfam00872
634177003719	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
634177003720	Transposase domain (DUF772); Region: DUF772; pfam05598
634177003721	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177003722	DDE superfamily endonuclease; Region: DDE_3; pfam13358
634177003723	Homeodomain-like domain; Region: HTH_23; cl17451
634177003724	Winged helix-turn helix; Region: HTH_29; pfam13551
634177003725	Squalene epoxidase; Region: SE; cl17314
634177003726	hypothetical protein; Provisional; Region: PRK09126
634177003727	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
634177003728	putative FMN binding site [chemical binding]; other site
634177003729	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
634177003730	putative active site pocket [active]
634177003731	4-fold oligomerization interface [polypeptide binding]; other site
634177003732	metal binding residues [ion binding]; metal-binding site
634177003733	3-fold/trimer interface [polypeptide binding]; other site
634177003734	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
634177003735	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
634177003736	putative active site [active]
634177003737	oxyanion strand; other site
634177003738	catalytic triad [active]
634177003739	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
634177003740	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634177003741	Coenzyme A binding pocket [chemical binding]; other site
634177003742	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
634177003743	catalytic residues [active]
634177003744	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
634177003745	substrate binding site [chemical binding]; other site
634177003746	glutamase interaction surface [polypeptide binding]; other site
634177003747	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
634177003748	metal binding site [ion binding]; metal-binding site
634177003749	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
634177003750	nucleotide binding site/active site [active]
634177003751	HIT family signature motif; other site
634177003752	catalytic residue [active]
634177003753	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
634177003754	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634177003755	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177003756	Walker A/P-loop; other site
634177003757	ATP binding site [chemical binding]; other site
634177003758	Q-loop/lid; other site
634177003759	ABC transporter signature motif; other site
634177003760	Walker B; other site
634177003761	D-loop; other site
634177003762	H-loop/switch region; other site
634177003763	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
634177003764	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
634177003765	minor groove reading motif; other site
634177003766	helix-hairpin-helix signature motif; other site
634177003767	substrate binding pocket [chemical binding]; other site
634177003768	active site
634177003769	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
634177003770	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
634177003771	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
634177003772	Competence protein; Region: Competence; pfam03772
634177003773	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
634177003774	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
634177003775	active site
634177003776	HIGH motif; other site
634177003777	KMSKS motif; other site
634177003778	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
634177003779	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
634177003780	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
634177003781	dihydroorotase; Validated; Region: PRK09059
634177003782	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634177003783	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
634177003784	active site
634177003785	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
634177003786	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
634177003787	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
634177003788	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
634177003789	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
634177003790	active site
634177003791	interdomain interaction site; other site
634177003792	putative metal-binding site [ion binding]; other site
634177003793	nucleotide binding site [chemical binding]; other site
634177003794	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
634177003795	domain I; other site
634177003796	DNA binding groove [nucleotide binding]
634177003797	phosphate binding site [ion binding]; other site
634177003798	domain II; other site
634177003799	domain III; other site
634177003800	nucleotide binding site [chemical binding]; other site
634177003801	catalytic site [active]
634177003802	domain IV; other site
634177003803	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
634177003804	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
634177003805	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
634177003806	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
634177003807	ribonuclease R; Region: RNase_R; TIGR02063
634177003808	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
634177003809	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
634177003810	RNA binding site [nucleotide binding]; other site
634177003811	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
634177003812	protein binding site [polypeptide binding]; other site
634177003813	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
634177003814	Catalytic dyad [active]
634177003815	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
634177003816	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
634177003817	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
634177003818	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
634177003819	ligand binding site [chemical binding]; other site
634177003820	cysteine synthase; Region: PLN02565
634177003821	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
634177003822	dimer interface [polypeptide binding]; other site
634177003823	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177003824	catalytic residue [active]
634177003825	Rrf2 family protein; Region: rrf2_super; TIGR00738
634177003826	Transcriptional regulator; Region: Rrf2; pfam02082
634177003827	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
634177003828	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177003829	ATP binding site [chemical binding]; other site
634177003830	Mg2+ binding site [ion binding]; other site
634177003831	G-X-G motif; other site
634177003832	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
634177003833	anchoring element; other site
634177003834	dimer interface [polypeptide binding]; other site
634177003835	ATP binding site [chemical binding]; other site
634177003836	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
634177003837	active site
634177003838	metal binding site [ion binding]; metal-binding site
634177003839	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
634177003840	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
634177003841	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
634177003842	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
634177003843	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177003844	ATP binding site [chemical binding]; other site
634177003845	Mg2+ binding site [ion binding]; other site
634177003846	G-X-G motif; other site
634177003847	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
634177003848	ATP binding site [chemical binding]; other site
634177003849	MutL C terminal dimerization domain; Region: MutL_C; pfam08676
634177003850	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
634177003851	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
634177003852	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
634177003853	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634177003854	active site
634177003855	HIGH motif; other site
634177003856	nucleotide binding site [chemical binding]; other site
634177003857	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
634177003858	active site
634177003859	KMSKS motif; other site
634177003860	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
634177003861	tRNA binding surface [nucleotide binding]; other site
634177003862	anticodon binding site; other site
634177003863	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
634177003864	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
634177003865	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
634177003866	active site
634177003867	Riboflavin kinase; Region: Flavokinase; smart00904
634177003868	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
634177003869	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
634177003870	Cupin domain; Region: Cupin_2; cl17218
634177003871	methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220
634177003872	intersubunit interface [polypeptide binding]; other site
634177003873	active site
634177003874	Zn2+ binding site [ion binding]; other site
634177003875	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
634177003876	CHAP domain; Region: CHAP; cl17642
634177003877	RecX family; Region: RecX; cl00936
634177003878	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
634177003879	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
634177003880	inhibitor-cofactor binding pocket; inhibition site
634177003881	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177003882	catalytic residue [active]
634177003883	ornithine carbamoyltransferase; Provisional; Region: PRK00779
634177003884	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
634177003885	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
634177003886	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
634177003887	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236
634177003888	dimerization interface [polypeptide binding]; other site
634177003889	domain crossover interface; other site
634177003890	redox-dependent activation switch; other site
634177003891	cytoskeletal protein RodZ; Provisional; Region: PRK10856
634177003892	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
634177003893	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
634177003894	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
634177003895	DsbD alpha interface [polypeptide binding]; other site
634177003896	catalytic residues [active]
634177003897	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
634177003898	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634177003899	ATP binding site [chemical binding]; other site
634177003900	putative Mg++ binding site [ion binding]; other site
634177003901	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634177003902	nucleotide binding region [chemical binding]; other site
634177003903	ATP-binding site [chemical binding]; other site
634177003904	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
634177003905	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
634177003906	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
634177003907	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
634177003908	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634177003909	protein binding site [polypeptide binding]; other site
634177003910	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634177003911	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177003912	active site
634177003913	phosphorylation site [posttranslational modification]
634177003914	intermolecular recognition site; other site
634177003915	dimerization interface [polypeptide binding]; other site
634177003916	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634177003917	DNA binding site [nucleotide binding]
634177003918	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634177003919	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
634177003920	dimerization interface [polypeptide binding]; other site
634177003921	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634177003922	dimer interface [polypeptide binding]; other site
634177003923	phosphorylation site [posttranslational modification]
634177003924	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177003925	ATP binding site [chemical binding]; other site
634177003926	Mg2+ binding site [ion binding]; other site
634177003927	G-X-G motif; other site
634177003928	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
634177003929	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
634177003930	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
634177003931	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
634177003932	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
634177003933	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
634177003934	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
634177003935	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
634177003936	active site
634177003937	dimer interface [polypeptide binding]; other site
634177003938	motif 1; other site
634177003939	motif 2; other site
634177003940	motif 3; other site
634177003941	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
634177003942	anticodon binding site; other site
634177003943	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
634177003944	putative active site [active]
634177003945	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634177003946	binding surface
634177003947	TPR motif; other site
634177003948	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634177003949	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
634177003950	putative ADP-binding pocket [chemical binding]; other site
634177003951	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
634177003952	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
634177003953	[2Fe-2S] cluster binding site [ion binding]; other site
634177003954	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
634177003955	trimer interface [polypeptide binding]; other site
634177003956	active site
634177003957	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275
634177003958	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
634177003959	hinge; other site
634177003960	active site
634177003961	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
634177003962	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
634177003963	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
634177003964	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
634177003965	NAD binding site [chemical binding]; other site
634177003966	dimerization interface [polypeptide binding]; other site
634177003967	product binding site; other site
634177003968	substrate binding site [chemical binding]; other site
634177003969	zinc binding site [ion binding]; other site
634177003970	catalytic residues [active]
634177003971	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
634177003972	rRNA binding site [nucleotide binding]; other site
634177003973	predicted 30S ribosome binding site; other site
634177003974	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
634177003975	active site
634177003976	dimer interface [polypeptide binding]; other site
634177003977	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
634177003978	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
634177003979	RNA binding site [nucleotide binding]; other site
634177003980	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
634177003981	Domain of unknown function (DUF329); Region: DUF329; pfam03884
634177003982	dihydroorotase; Validated; Region: PRK09060
634177003983	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634177003984	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
634177003985	active site
634177003986	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
634177003987	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
634177003988	putative active site [active]
634177003989	heme pocket [chemical binding]; other site
634177003990	GAF domain; Region: GAF_2; pfam13185
634177003991	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
634177003992	metal binding site [ion binding]; metal-binding site
634177003993	active site
634177003994	I-site; other site
634177003995	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
634177003996	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
634177003997	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
634177003998	putative active site [active]
634177003999	heme pocket [chemical binding]; other site
634177004000	GAF domain; Region: GAF_2; pfam13185
634177004001	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
634177004002	metal binding site [ion binding]; metal-binding site
634177004003	active site
634177004004	I-site; other site
634177004005	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
634177004006	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
634177004007	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
634177004008	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
634177004009	metal binding site [ion binding]; metal-binding site
634177004010	active site
634177004011	I-site; other site
634177004012	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
634177004013	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
634177004014	conjugal transfer protein TrbL; Provisional; Region: PRK13875
634177004015	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
634177004016	dinuclear metal binding motif [ion binding]; other site
634177004017	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
634177004018	oligomer interface [polypeptide binding]; other site
634177004019	active site residues [active]
634177004020	OmpA family; Region: OmpA; pfam00691
634177004021	ligand binding site [chemical binding]; other site
634177004022	aminotransferase; Validated; Region: PRK09148
634177004023	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634177004024	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177004025	homodimer interface [polypeptide binding]; other site
634177004026	catalytic residue [active]
634177004027	homoserine dehydrogenase; Provisional; Region: PRK06349
634177004028	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
634177004029	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
634177004030	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
634177004031	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
634177004032	DHH family; Region: DHH; pfam01368
634177004033	DHHA1 domain; Region: DHHA1; pfam02272
634177004034	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl19279
634177004035	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
634177004036	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634177004037	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
634177004038	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634177004039	active site
634177004040	DNA polymerase III subunit epsilon; Validated; Region: PRK09182
634177004041	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
634177004042	active site
634177004043	catalytic site [active]
634177004044	substrate binding site [chemical binding]; other site
634177004045	Inward rectifier potassium channel; Region: IRK; pfam01007
634177004046	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
634177004047	inhibitor binding site; inhibition site
634177004048	catalytic motif [active]
634177004049	Catalytic residue [active]
634177004050	Active site flap [active]
634177004051	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
634177004052	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177004053	Walker A/P-loop; other site
634177004054	ATP binding site [chemical binding]; other site
634177004055	Q-loop/lid; other site
634177004056	ABC transporter signature motif; other site
634177004057	Walker B; other site
634177004058	D-loop; other site
634177004059	H-loop/switch region; other site
634177004060	Protein of unknown function (DUF763); Region: DUF763; pfam05559
634177004061	manganese transport regulator MntR; Provisional; Region: PRK11050
634177004062	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
634177004063	Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742
634177004064	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
634177004065	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634177004066	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
634177004067	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
634177004068	Protein of unknown function (DUF1643); Region: DUF1643; pfam07799
634177004069	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
634177004070	active site
634177004071	DNA polymerase IV; Validated; Region: PRK02406
634177004072	DNA binding site [nucleotide binding]
634177004073	hypothetical protein; Provisional; Region: PRK10316
634177004074	YfdX protein; Region: YfdX; pfam10938
634177004075	Protein of unknown function (DUF2757); Region: DUF2757; pfam10955
634177004076	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634177004077	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177004078	active site
634177004079	phosphorylation site [posttranslational modification]
634177004080	intermolecular recognition site; other site
634177004081	dimerization interface [polypeptide binding]; other site
634177004082	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634177004083	DNA binding site [nucleotide binding]
634177004084	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
634177004085	dimer interface [polypeptide binding]; other site
634177004086	substrate binding site [chemical binding]; other site
634177004087	ATP binding site [chemical binding]; other site
634177004088	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
634177004089	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
634177004090	active site
634177004091	substrate binding site [chemical binding]; other site
634177004092	metal binding site [ion binding]; metal-binding site
634177004093	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
634177004094	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
634177004095	substrate binding pocket [chemical binding]; other site
634177004096	dimer interface [polypeptide binding]; other site
634177004097	inhibitor binding site; inhibition site
634177004098	FtsH Extracellular; Region: FtsH_ext; pfam06480
634177004099	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
634177004100	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177004101	Walker A motif; other site
634177004102	ATP binding site [chemical binding]; other site
634177004103	Walker B motif; other site
634177004104	arginine finger; other site
634177004105	Peptidase family M41; Region: Peptidase_M41; pfam01434
634177004106	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
634177004107	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
634177004108	Ligand Binding Site [chemical binding]; other site
634177004109	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
634177004110	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
634177004111	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
634177004112	ligand binding site [chemical binding]; other site
634177004113	translocation protein TolB; Provisional; Region: tolB; PRK05137
634177004114	TolB amino-terminal domain; Region: TolB_N; pfam04052
634177004115	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
634177004116	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
634177004117	TolR protein; Region: tolR; TIGR02801
634177004118	TolQ protein; Region: tolQ; TIGR02796
634177004119	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
634177004120	active site
634177004121	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
634177004122	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
634177004123	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177004124	Walker A motif; other site
634177004125	ATP binding site [chemical binding]; other site
634177004126	Walker B motif; other site
634177004127	arginine finger; other site
634177004128	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
634177004129	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
634177004130	RuvA N terminal domain; Region: RuvA_N; pfam01330
634177004131	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
634177004132	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
634177004133	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
634177004134	active site
634177004135	putative DNA-binding cleft [nucleotide binding]; other site
634177004136	dimer interface [polypeptide binding]; other site
634177004137	hypothetical protein; Validated; Region: PRK00110
634177004138	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
634177004139	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
634177004140	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
634177004141	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634177004142	nucleotide binding region [chemical binding]; other site
634177004143	ATP-binding site [chemical binding]; other site
634177004144	SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516
634177004145	SEC-C motif; Region: SEC-C; pfam02810
634177004146	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
634177004147	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
634177004148	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
634177004149	heterotetramer interface [polypeptide binding]; other site
634177004150	active site pocket [active]
634177004151	cleavage site
634177004152	RDD family; Region: RDD; pfam06271
634177004153	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
634177004154	Mechanosensitive ion channel; Region: MS_channel; pfam00924
634177004155	2OG-Fe dioxygenase; Region: 2OG-Fe_Oxy_2; pfam10014
634177004156	Permease; Region: Permease; pfam02405
634177004157	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
634177004158	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177004159	Walker A/P-loop; other site
634177004160	ATP binding site [chemical binding]; other site
634177004161	Q-loop/lid; other site
634177004162	ABC transporter signature motif; other site
634177004163	Walker B; other site
634177004164	D-loop; other site
634177004165	H-loop/switch region; other site
634177004166	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
634177004167	mce related protein; Region: MCE; pfam02470
634177004168	Protein of unknown function (DUF330); Region: DUF330; pfam03886
634177004169	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
634177004170	homodimer interface [polypeptide binding]; other site
634177004171	substrate-cofactor binding pocket; other site
634177004172	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177004173	catalytic residue [active]
634177004174	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
634177004175	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
634177004176	active site
634177004177	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
634177004178	intracellular protease, PfpI family; Region: PfpI; TIGR01382
634177004179	conserved cys residue [active]
634177004180	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
634177004181	MPT binding site; other site
634177004182	trimer interface [polypeptide binding]; other site
634177004183	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634177004184	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
634177004185	active site
634177004186	substrate binding site [chemical binding]; other site
634177004187	Phosphotransferase enzyme family; Region: APH; pfam01636
634177004188	ATP binding site [chemical binding]; other site
634177004189	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
634177004190	nudix motif; other site
634177004191	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
634177004192	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
634177004193	dimer interface [polypeptide binding]; other site
634177004194	PYR/PP interface [polypeptide binding]; other site
634177004195	TPP binding site [chemical binding]; other site
634177004196	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634177004197	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
634177004198	TPP-binding site [chemical binding]; other site
634177004199	dimer interface [polypeptide binding]; other site
634177004200	D-lactate dehydrogenase; Provisional; Region: PRK11183
634177004201	FAD binding domain; Region: FAD_binding_4; cl19922
634177004202	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
634177004203	acetolactate synthase; Reviewed; Region: PRK08617
634177004204	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
634177004205	PYR/PP interface [polypeptide binding]; other site
634177004206	dimer interface [polypeptide binding]; other site
634177004207	TPP binding site [chemical binding]; other site
634177004208	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634177004209	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
634177004210	TPP-binding site [chemical binding]; other site
634177004211	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
634177004212	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
634177004213	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
634177004214	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
634177004215	HSP70 interaction site [polypeptide binding]; other site
634177004216	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
634177004217	substrate binding site [polypeptide binding]; other site
634177004218	dimer interface [polypeptide binding]; other site
634177004219	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634177004220	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
634177004221	FlgN protein; Region: FlgN; pfam05130
634177004222	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
634177004223	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
634177004224	active site
634177004225	catalytic tetrad [active]
634177004226	Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; pfam10030
634177004227	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
634177004228	active site residue [active]
634177004229	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
634177004230	dimer interface [polypeptide binding]; other site
634177004231	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177004232	catalytic residue [active]
634177004233	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634177004234	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177004235	active site
634177004236	phosphorylation site [posttranslational modification]
634177004237	intermolecular recognition site; other site
634177004238	dimerization interface [polypeptide binding]; other site
634177004239	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634177004240	DNA binding site [nucleotide binding]
634177004241	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
634177004242	dimerization interface [polypeptide binding]; other site
634177004243	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634177004244	dimer interface [polypeptide binding]; other site
634177004245	phosphorylation site [posttranslational modification]
634177004246	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177004247	ATP binding site [chemical binding]; other site
634177004248	Mg2+ binding site [ion binding]; other site
634177004249	G-X-G motif; other site
634177004250	OsmC-like protein; Region: OsmC; cl00767
634177004251	Predicted membrane protein [Function unknown]; Region: COG1238
634177004252	short chain dehydrogenase; Provisional; Region: PRK07109
634177004253	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177004254	NAD(P) binding site [chemical binding]; other site
634177004255	active site
634177004256	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
634177004257	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
634177004258	Tetratricopeptide repeat; Region: TPR_16; pfam13432
634177004259	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634177004260	binding surface
634177004261	TPR repeat; Region: TPR_11; pfam13414
634177004262	TPR motif; other site
634177004263	TPR repeat; Region: TPR_11; pfam13414
634177004264	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634177004265	binding surface
634177004266	TPR motif; other site
634177004267	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
634177004268	Fe-S cluster binding site [ion binding]; other site
634177004269	active site
634177004270	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634177004271	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634177004272	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634177004273	catalytic residue [active]
634177004274	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
634177004275	Domain of unknown function DUF21; Region: DUF21; pfam01595
634177004276	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
634177004277	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
634177004278	Transporter associated domain; Region: CorC_HlyC; smart01091
634177004279	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
634177004280	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634177004281	FeS/SAM binding site; other site
634177004282	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962
634177004283	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
634177004284	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
634177004285	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
634177004286	TPP-binding site; other site
634177004287	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
634177004288	PYR/PP interface [polypeptide binding]; other site
634177004289	dimer interface [polypeptide binding]; other site
634177004290	TPP binding site [chemical binding]; other site
634177004291	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634177004292	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
634177004293	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
634177004294	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
634177004295	ligand binding site; other site
634177004296	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
634177004297	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
634177004298	B12 binding site [chemical binding]; other site
634177004299	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634177004300	FeS/SAM binding site; other site
634177004301	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
634177004302	putative active site [active]
634177004303	YdjC motif; other site
634177004304	Mg binding site [ion binding]; other site
634177004305	putative homodimer interface [polypeptide binding]; other site
634177004306	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
634177004307	catalytic residues [active]
634177004308	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
634177004309	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
634177004310	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402
634177004311	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
634177004312	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
634177004313	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402
634177004314	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
634177004315	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
634177004316	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
634177004317	Substrate binding site; other site
634177004318	metal-binding site
634177004319	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
634177004320	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
634177004321	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177004322	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177004323	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
634177004324	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177004325	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
634177004326	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
634177004327	G1 box; other site
634177004328	putative GEF interaction site [polypeptide binding]; other site
634177004329	GTP/Mg2+ binding site [chemical binding]; other site
634177004330	Switch I region; other site
634177004331	G2 box; other site
634177004332	G3 box; other site
634177004333	Switch II region; other site
634177004334	G4 box; other site
634177004335	G5 box; other site
634177004336	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
634177004337	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
634177004338	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
634177004339	adenosine kinase; Provisional; Region: PTZ00247
634177004340	substrate binding site [chemical binding]; other site
634177004341	ATP binding site [chemical binding]; other site
634177004342	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
634177004343	GcrA cell cycle regulator; Region: GcrA; cl11564
634177004344	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
634177004345	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
634177004346	catalytic site [active]
634177004347	putative active site [active]
634177004348	putative substrate binding site [chemical binding]; other site
634177004349	HRDC domain; Region: HRDC; pfam00570
634177004350	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
634177004351	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
634177004352	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
634177004353	gamma subunit interface [polypeptide binding]; other site
634177004354	epsilon subunit interface [polypeptide binding]; other site
634177004355	LBP interface [polypeptide binding]; other site
634177004356	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
634177004357	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
634177004358	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
634177004359	alpha subunit interaction interface [polypeptide binding]; other site
634177004360	Walker A motif; other site
634177004361	ATP binding site [chemical binding]; other site
634177004362	Walker B motif; other site
634177004363	inhibitor binding site; inhibition site
634177004364	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
634177004365	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
634177004366	core domain interface [polypeptide binding]; other site
634177004367	delta subunit interface [polypeptide binding]; other site
634177004368	epsilon subunit interface [polypeptide binding]; other site
634177004369	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
634177004370	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
634177004371	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
634177004372	beta subunit interaction interface [polypeptide binding]; other site
634177004373	Walker A motif; other site
634177004374	ATP binding site [chemical binding]; other site
634177004375	Walker B motif; other site
634177004376	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
634177004377	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
634177004378	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177004379	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634177004380	putative substrate translocation pore; other site
634177004381	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
634177004382	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
634177004383	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
634177004384	putative homodimer interface [polypeptide binding]; other site
634177004385	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
634177004386	heterodimer interface [polypeptide binding]; other site
634177004387	homodimer interface [polypeptide binding]; other site
634177004388	Protein of unknown function (DUF330); Region: DUF330; pfam03886
634177004389	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
634177004390	mce related protein; Region: MCE; pfam02470
634177004391	mce related protein; Region: MCE; pfam02470
634177004392	mce related protein; Region: MCE; pfam02470
634177004393	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
634177004394	Paraquat-inducible protein A; Region: PqiA; pfam04403
634177004395	Paraquat-inducible protein A; Region: PqiA; pfam04403
634177004396	GntP family permease; Region: GntP_permease; pfam02447
634177004397	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
634177004398	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
634177004399	Outer membrane efflux protein; Region: OEP; pfam02321
634177004400	Outer membrane efflux protein; Region: OEP; pfam02321
634177004401	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
634177004402	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
634177004403	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
634177004404	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
634177004405	Walker A/P-loop; other site
634177004406	ATP binding site [chemical binding]; other site
634177004407	Q-loop/lid; other site
634177004408	ABC transporter signature motif; other site
634177004409	Walker B; other site
634177004410	D-loop; other site
634177004411	H-loop/switch region; other site
634177004412	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177004413	Walker A/P-loop; other site
634177004414	ATP binding site [chemical binding]; other site
634177004415	Q-loop/lid; other site
634177004416	ABC transporter signature motif; other site
634177004417	Walker B; other site
634177004418	D-loop; other site
634177004419	H-loop/switch region; other site
634177004420	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
634177004421	Acyltransferase family; Region: Acyl_transf_3; cl19154
634177004422	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
634177004423	HlyD family secretion protein; Region: HlyD_3; pfam13437
634177004424	Transcriptional regulators [Transcription]; Region: MarR; COG1846
634177004425	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
634177004426	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634177004427	Fusaric acid resistance protein-like; Region: FUSC_2; cl19401
634177004428	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
634177004429	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634177004430	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
634177004431	N-terminal domain interface [polypeptide binding]; other site
634177004432	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
634177004433	iron-sulfur cluster [ion binding]; other site
634177004434	[2Fe-2S] cluster binding site [ion binding]; other site
634177004435	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
634177004436	hydrophobic ligand binding site; other site
634177004437	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
634177004438	Cl- selectivity filter; other site
634177004439	Cl- binding residues [ion binding]; other site
634177004440	pore gating glutamate residue; other site
634177004441	dimer interface [polypeptide binding]; other site
634177004442	Nitrogen regulatory protein P-II; Region: P-II; smart00938
634177004443	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
634177004444	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
634177004445	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634177004446	Coenzyme A binding pocket [chemical binding]; other site
634177004447	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634177004448	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634177004449	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634177004450	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634177004451	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
634177004452	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634177004453	Outer membrane efflux protein; Region: OEP; pfam02321
634177004454	Outer membrane efflux protein; Region: OEP; pfam02321
634177004455	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
634177004456	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634177004457	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
634177004458	active site
634177004459	catalytic residues [active]
634177004460	DNA binding site [nucleotide binding]
634177004461	Int/Topo IB signature motif; other site
634177004462	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634177004463	ATP binding site [chemical binding]; other site
634177004464	putative Mg++ binding site [ion binding]; other site
634177004465	Nuclear pore protein 84 / 107; Region: Nup84_Nup100; pfam04121
634177004466	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
634177004467	PAS domain; Region: PAS_9; pfam13426
634177004468	putative active site [active]
634177004469	heme pocket [chemical binding]; other site
634177004470	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
634177004471	metal binding site [ion binding]; metal-binding site
634177004472	active site
634177004473	I-site; other site
634177004474	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
634177004475	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
634177004476	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
634177004477	putative active site [active]
634177004478	heme pocket [chemical binding]; other site
634177004479	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
634177004480	metal binding site [ion binding]; metal-binding site
634177004481	active site
634177004482	I-site; other site
634177004483	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
634177004484	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
634177004485	putative acyl-acceptor binding pocket; other site
634177004486	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
634177004487	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
634177004488	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
634177004489	catalytic triad [active]
634177004490	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634177004491	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634177004492	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634177004493	catalytic residue [active]
634177004494	Sporulation related domain; Region: SPOR; pfam05036
634177004495	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
634177004496	active site
634177004497	catalytic tetrad [active]
634177004498	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
634177004499	active site
634177004500	dimer interface [polypeptide binding]; other site
634177004501	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
634177004502	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
634177004503	homotetramer interface [polypeptide binding]; other site
634177004504	ligand binding site [chemical binding]; other site
634177004505	catalytic site [active]
634177004506	NAD binding site [chemical binding]; other site
634177004507	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
634177004508	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
634177004509	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
634177004510	Cl binding site [ion binding]; other site
634177004511	oligomer interface [polypeptide binding]; other site
634177004512	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
634177004513	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
634177004514	putative ligand binding site [chemical binding]; other site
634177004515	NAD binding site [chemical binding]; other site
634177004516	dimerization interface [polypeptide binding]; other site
634177004517	catalytic site [active]
634177004518	EthD domain; Region: EthD; cl17553
634177004519	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634177004520	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634177004521	Amidase; Region: Amidase; cl11426
634177004522	Transposase, Mutator family; Region: Transposase_mut; pfam00872
634177004523	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
634177004524	Amidase; Region: Amidase; cl11426
634177004525	hypothetical protein; Provisional; Region: PRK06486
634177004526	intersubunit interface [polypeptide binding]; other site
634177004527	active site
634177004528	Zn2+ binding site [ion binding]; other site
634177004529	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
634177004530	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177004531	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177004532	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
634177004533	dimerization interface [polypeptide binding]; other site
634177004534	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
634177004535	Na binding site [ion binding]; other site
634177004536	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
634177004537	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
634177004538	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634177004539	catalytic residue [active]
634177004540	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
634177004541	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
634177004542	putative DNA binding site [nucleotide binding]; other site
634177004543	dimerization interface [polypeptide binding]; other site
634177004544	putative Zn2+ binding site [ion binding]; other site
634177004545	AsnC family; Region: AsnC_trans_reg; pfam01037
634177004546	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634177004547	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177004548	Transposase domain (DUF772); Region: DUF772; pfam05598
634177004549	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
634177004550	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
634177004551	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634177004552	binding surface
634177004553	TPR motif; other site
634177004554	Tetratricopeptide repeat; Region: TPR_20; pfam14561
634177004555	ATP-dependent protease La (LON) domain; Region: LON; cl19481
634177004556	Uncharacterized conserved protein [Function unknown]; Region: COG2835
634177004557	Pantoate-beta-alanine ligase; Region: PanC; cd00560
634177004558	active site
634177004559	ATP-binding site [chemical binding]; other site
634177004560	pantoate-binding site; other site
634177004561	HXXH motif; other site
634177004562	siroheme synthase; Provisional; Region: cysG; PRK10637
634177004563	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
634177004564	Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414
634177004565	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
634177004566	active site
634177004567	SAM binding site [chemical binding]; other site
634177004568	homodimer interface [polypeptide binding]; other site
634177004569	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634177004570	Fusaric acid resistance protein-like; Region: FUSC_2; cl19401
634177004571	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
634177004572	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
634177004573	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634177004574	HlyD family secretion protein; Region: HlyD_3; pfam13437
634177004575	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
634177004576	nucleoside/Zn binding site; other site
634177004577	dimer interface [polypeptide binding]; other site
634177004578	catalytic motif [active]
634177004579	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
634177004580	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
634177004581	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558
634177004582	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
634177004583	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177004584	Walker A/P-loop; other site
634177004585	ATP binding site [chemical binding]; other site
634177004586	Q-loop/lid; other site
634177004587	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177004588	ATP binding site [chemical binding]; other site
634177004589	Q-loop/lid; other site
634177004590	ABC transporter signature motif; other site
634177004591	Walker B; other site
634177004592	D-loop; other site
634177004593	H-loop/switch region; other site
634177004594	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177004595	Walker A/P-loop; other site
634177004596	ATP binding site [chemical binding]; other site
634177004597	Q-loop/lid; other site
634177004598	ABC transporter signature motif; other site
634177004599	Walker B; other site
634177004600	D-loop; other site
634177004601	H-loop/switch region; other site
634177004602	fructuronate transporter; Provisional; Region: PRK10034; cl15264
634177004603	GntP family permease; Region: GntP_permease; pfam02447
634177004604	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177004605	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177004606	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
634177004607	active site
634177004608	catalytic residues [active]
634177004609	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
634177004610	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
634177004611	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
634177004612	Restriction endonuclease; Region: Mrr_cat; pfam04471
634177004613	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
634177004614	active site
634177004615	catalytic triad [active]
634177004616	oxyanion hole [active]
634177004617	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
634177004618	Sulfatase; Region: Sulfatase; pfam00884
634177004619	isocitrate dehydrogenase; Validated; Region: PRK08299
634177004620	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
634177004621	Transcriptional regulator; Region: Rrf2; cl17282
634177004622	Rrf2 family protein; Region: rrf2_super; TIGR00738
634177004623	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
634177004624	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
634177004625	FMN binding site [chemical binding]; other site
634177004626	dimer interface [polypeptide binding]; other site
634177004627	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
634177004628	active site
634177004629	catalytic residues [active]
634177004630	CHRD domain; Region: CHRD; pfam07452
634177004631	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177004632	NAD(P) binding site [chemical binding]; other site
634177004633	active site
634177004634	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
634177004635	homotrimer interaction site [polypeptide binding]; other site
634177004636	putative active site [active]
634177004637	potential frameshift: common BLAST hit: gi|209543825|ref|YP_002276054.1| transposase IS1182 family protein
634177004638	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
634177004639	potential frameshift: common BLAST hit: gi|209545168|ref|YP_002277397.1| transposase IS1182 family protein
634177004640	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
634177004641	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
634177004642	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
634177004643	integrase; Provisional; Region: PRK09692
634177004644	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
634177004645	active site
634177004646	Int/Topo IB signature motif; other site
634177004647	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
634177004648	ParB-like nuclease domain; Region: ParBc; pfam02195
634177004649	plasmid partitioning protein; Provisional; Region: PRK13832
634177004650	catabolite control protein A; Region: ccpA; TIGR01481
634177004651	Toprim domain; Region: Toprim_3; pfam13362
634177004652	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
634177004653	active site
634177004654	DNA-binding transcriptional regulator Cro; Region: P22_Cro; cl18770
634177004655	Phage terminase, small subunit; Region: Terminase_4; pfam05119
634177004656	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
634177004657	Phage Terminase; Region: Terminase_1; cl19862
634177004658	Phage portal protein; Region: Phage_portal; pfam04860
634177004659	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
634177004660	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
634177004661	Phage capsid family; Region: Phage_capsid; pfam05065
634177004662	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
634177004663	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
634177004664	oligomerization interface [polypeptide binding]; other site
634177004665	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
634177004666	Protein of unknown function (DUF2635); Region: DUF2635; pfam10948
634177004667	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
634177004668	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
634177004669	Phage tail tube protein; Region: Tail_tube; pfam10618
634177004670	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
634177004671	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
634177004672	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634177004673	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634177004674	catalytic residue [active]
634177004675	DNA circularisation protein N-terminus; Region: DNA_circ_N; cl19561
634177004676	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
634177004677	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410
634177004678	Phage protein GP46; Region: GP46; cl01814
634177004679	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
634177004680	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
634177004681	Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; cl12124
634177004682	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
634177004683	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842
634177004684	Phage Terminase; Region: Terminase_1; cl19862
634177004685	Terminase-like family; Region: Terminase_6; pfam03237
634177004686	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634177004687	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634177004688	catalytic residues [active]
634177004689	catalytic nucleophile [active]
634177004690	Presynaptic Site I dimer interface [polypeptide binding]; other site
634177004691	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634177004692	Synaptic Flat tetramer interface [polypeptide binding]; other site
634177004693	Synaptic Site I dimer interface [polypeptide binding]; other site
634177004694	DNA binding site [nucleotide binding]
634177004695	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
634177004696	DNA-binding interface [nucleotide binding]; DNA binding site
634177004697	hypothetical protein; Provisional; Region: PRK14709
634177004698	D5 N terminal like; Region: D5_N; smart00885
634177004699	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
634177004700	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
634177004701	polymerase nucleotide-binding site; other site
634177004702	DNA-binding residues [nucleotide binding]; DNA binding site
634177004703	nucleotide binding site [chemical binding]; other site
634177004704	primase nucleotide-binding site [nucleotide binding]; other site
634177004705	Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362
634177004706	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
634177004707	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
634177004708	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
634177004709	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
634177004710	active site
634177004711	Int/Topo IB signature motif; other site
634177004712	Cupin domain; Region: Cupin_2; cl17218
634177004713	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
634177004714	PAS domain; Region: PAS_8; pfam13188
634177004715	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
634177004716	putative active site [active]
634177004717	heme pocket [chemical binding]; other site
634177004718	GAF domain; Region: GAF_2; pfam13185
634177004719	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
634177004720	metal binding site [ion binding]; metal-binding site
634177004721	active site
634177004722	I-site; other site
634177004723	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
634177004724	Homeodomain-like domain; Region: HTH_23; cl17451
634177004725	Winged helix-turn helix; Region: HTH_29; pfam13551
634177004726	DDE superfamily endonuclease; Region: DDE_3; cl19249
634177004727	Transposase, Mutator family; Region: Transposase_mut; pfam00872
634177004728	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
634177004729	DDE superfamily endonuclease; Region: DDE_3; pfam13358
634177004730	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634177004731	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634177004732	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
634177004733	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
634177004734	active site
634177004735	catalytic site [active]
634177004736	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
634177004737	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
634177004738	substrate binding site [chemical binding]; other site
634177004739	dimer interface [polypeptide binding]; other site
634177004740	ATP binding site [chemical binding]; other site
634177004741	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634177004742	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
634177004743	active site
634177004744	catalytic residues [active]
634177004745	metal binding site [ion binding]; metal-binding site
634177004746	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
634177004747	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177004748	active site
634177004749	phosphorylation site [posttranslational modification]
634177004750	intermolecular recognition site; other site
634177004751	dimerization interface [polypeptide binding]; other site
634177004752	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634177004753	DNA binding site [nucleotide binding]
634177004754	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
634177004755	PhoU domain; Region: PhoU; pfam01895
634177004756	PhoU domain; Region: PhoU; pfam01895
634177004757	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634177004758	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634177004759	putative symporter YagG; Provisional; Region: PRK09669; cl15392
634177004760	MFS/sugar transport protein; Region: MFS_2; pfam13347
634177004761	active site
634177004762	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
634177004763	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177004764	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
634177004765	Walker A motif; other site
634177004766	ATP binding site [chemical binding]; other site
634177004767	Walker B motif; other site
634177004768	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177004769	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
634177004770	Walker A motif; other site
634177004771	ATP binding site [chemical binding]; other site
634177004772	Walker B motif; other site
634177004773	arginine finger; other site
634177004774	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
634177004775	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
634177004776	active site
634177004777	1,3-beta-glucan synthase component; Region: Glucan_synthase; pfam02364
634177004778	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
634177004779	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
634177004780	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
634177004781	Major royal jelly protein; Region: MRJP; pfam03022
634177004782	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634177004783	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634177004784	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
634177004785	dimer interface [polypeptide binding]; other site
634177004786	active site
634177004787	metal binding site [ion binding]; metal-binding site
634177004788	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
634177004789	NAD(P) binding site [chemical binding]; other site
634177004790	catalytic residues [active]
634177004791	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634177004792	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
634177004793	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
634177004794	[2Fe-2S] cluster binding site [ion binding]; other site
634177004795	glutaredoxin 2; Provisional; Region: PRK10387
634177004796	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
634177004797	C-terminal domain interface [polypeptide binding]; other site
634177004798	GSH binding site (G-site) [chemical binding]; other site
634177004799	catalytic residues [active]
634177004800	putative dimer interface [polypeptide binding]; other site
634177004801	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
634177004802	N-terminal domain interface [polypeptide binding]; other site
634177004803	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
634177004804	DNA photolyase; Region: DNA_photolyase; pfam00875
634177004805	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
634177004806	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
634177004807	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
634177004808	classical (c) SDRs; Region: SDR_c; cd05233
634177004809	NAD(P) binding site [chemical binding]; other site
634177004810	active site
634177004811	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
634177004812	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
634177004813	Strictosidine synthase; Region: Str_synth; cl19733
634177004814	fumarate hydratase; Reviewed; Region: fumC; PRK00485
634177004815	Class II fumarases; Region: Fumarase_classII; cd01362
634177004816	active site
634177004817	tetramer interface [polypeptide binding]; other site
634177004818	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
634177004819	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
634177004820	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
634177004821	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
634177004822	ABC-ATPase subunit  interface; other site
634177004823	dimer interface [polypeptide binding]; other site
634177004824	putative PBP binding regions; other site
634177004825	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
634177004826	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
634177004827	intersubunit interface [polypeptide binding]; other site
634177004828	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
634177004829	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
634177004830	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
634177004831	Protein of unknown function (DUF2501); Region: DUF2501; cl08197
634177004832	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
634177004833	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
634177004834	peptide binding site [polypeptide binding]; other site
634177004835	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
634177004836	Cu(I) binding site [ion binding]; other site
634177004837	DNA polymerase I; Provisional; Region: PRK05755
634177004838	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
634177004839	active site
634177004840	metal binding site 1 [ion binding]; metal-binding site
634177004841	putative 5' ssDNA interaction site; other site
634177004842	metal binding site 3; metal-binding site
634177004843	metal binding site 2 [ion binding]; metal-binding site
634177004844	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
634177004845	putative DNA binding site [nucleotide binding]; other site
634177004846	putative metal binding site [ion binding]; other site
634177004847	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
634177004848	active site
634177004849	catalytic site [active]
634177004850	substrate binding site [chemical binding]; other site
634177004851	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
634177004852	active site
634177004853	DNA binding site [nucleotide binding]
634177004854	catalytic site [active]
634177004855	Zinc-finger domain; Region: zf-CHCC; pfam10276
634177004856	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
634177004857	Putative lysophospholipase; Region: Hydrolase_4; cl19140
634177004858	Putative lysophospholipase; Region: Hydrolase_4; cl19140
634177004859	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634177004860	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634177004861	catalytic residues [active]
634177004862	catalytic nucleophile [active]
634177004863	Presynaptic Site I dimer interface [polypeptide binding]; other site
634177004864	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634177004865	Synaptic Flat tetramer interface [polypeptide binding]; other site
634177004866	Synaptic Site I dimer interface [polypeptide binding]; other site
634177004867	DNA binding site [nucleotide binding]
634177004868	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393
634177004869	DNA-binding interface [nucleotide binding]; DNA binding site
634177004870	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
634177004871	active site
634177004872	metal binding site [ion binding]; metal-binding site
634177004873	interdomain interaction site; other site
634177004874	Domain of unknown function (DUF927); Region: DUF927; pfam06048
634177004875	hypothetical protein; Validated; Region: PRK07078
634177004876	Helix-turn-helix domain; Region: HTH_17; cl17695
634177004877	'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The...; Region: SANT; cl17250
634177004878	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634177004879	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634177004880	non-specific DNA binding site [nucleotide binding]; other site
634177004881	salt bridge; other site
634177004882	sequence-specific DNA binding site [nucleotide binding]; other site
634177004883	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
634177004884	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
634177004885	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
634177004886	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
634177004887	active site
634177004888	Int/Topo IB signature motif; other site
634177004889	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
634177004890	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
634177004891	Sulfate transporter family; Region: Sulfate_transp; pfam00916
634177004892	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
634177004893	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
634177004894	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
634177004895	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
634177004896	putative active site [active]
634177004897	catalytic site [active]
634177004898	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
634177004899	putative active site [active]
634177004900	catalytic site [active]
634177004901	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177004902	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177004903	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177004904	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177004905	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634177004906	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634177004907	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177004908	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177004909	potential frameshift: common BLAST hit: gi|209543607|ref|YP_002275836.1| transposase IS630
634177004910	DDE superfamily endonuclease; Region: DDE_3; cl19249
634177004911	Winged helix-turn helix; Region: HTH_33; pfam13592
634177004912	Transposase, Mutator family; Region: Transposase_mut; pfam00872
634177004913	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
634177004914	Helix-turn-helix domain; Region: HTH_28; pfam13518
634177004915	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634177004916	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634177004917	zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005
634177004918	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634177004919	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634177004920	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634177004921	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634177004922	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
634177004923	DDE superfamily endonuclease; Region: DDE_3; cl19249
634177004924	Homeodomain-like domain; Region: HTH_23; pfam13384
634177004925	Winged helix-turn helix; Region: HTH_29; pfam13551
634177004926	Homeodomain-like domain; Region: HTH_32; pfam13565
634177004927	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
634177004928	Clp amino terminal domain; Region: Clp_N; pfam02861
634177004929	Clp amino terminal domain; Region: Clp_N; pfam02861
634177004930	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177004931	Walker A motif; other site
634177004932	ATP binding site [chemical binding]; other site
634177004933	Walker B motif; other site
634177004934	arginine finger; other site
634177004935	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177004936	Walker A motif; other site
634177004937	ATP binding site [chemical binding]; other site
634177004938	Walker B motif; other site
634177004939	arginine finger; other site
634177004940	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
634177004941	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
634177004942	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
634177004943	active site
634177004944	catalytic tetrad [active]
634177004945	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
634177004946	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
634177004947	ketol-acid reductoisomerase; Provisional; Region: PRK05479
634177004948	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
634177004949	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
634177004950	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
634177004951	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
634177004952	putative valine binding site [chemical binding]; other site
634177004953	dimer interface [polypeptide binding]; other site
634177004954	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
634177004955	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
634177004956	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
634177004957	PYR/PP interface [polypeptide binding]; other site
634177004958	dimer interface [polypeptide binding]; other site
634177004959	TPP binding site [chemical binding]; other site
634177004960	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634177004961	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
634177004962	TPP-binding site [chemical binding]; other site
634177004963	dimer interface [polypeptide binding]; other site
634177004964	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
634177004965	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
634177004966	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
634177004967	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634177004968	motif II; other site
634177004969	Cation efflux family; Region: Cation_efflux; pfam01545
634177004970	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
634177004971	putative active site [active]
634177004972	catalytic triad [active]
634177004973	dimer interface [polypeptide binding]; other site
634177004974	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
634177004975	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
634177004976	hypothetical protein; Provisional; Region: PRK05170
634177004977	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
634177004978	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
634177004979	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177004980	Walker A/P-loop; other site
634177004981	ATP binding site [chemical binding]; other site
634177004982	Q-loop/lid; other site
634177004983	ABC transporter signature motif; other site
634177004984	Walker B; other site
634177004985	D-loop; other site
634177004986	H-loop/switch region; other site
634177004987	TOBE domain; Region: TOBE_2; pfam08402
634177004988	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
634177004989	Transcriptional regulators [Transcription]; Region: MarR; COG1846
634177004990	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
634177004991	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
634177004992	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634177004993	HlyD family secretion protein; Region: HlyD_3; pfam13437
634177004994	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634177004995	Outer membrane efflux protein; Region: OEP; pfam02321
634177004996	Outer membrane efflux protein; Region: OEP; pfam02321
634177004997	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
634177004998	Transposase domain (DUF772); Region: DUF772; pfam05598
634177004999	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177005000	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177005001	AAA ATPase domain; Region: AAA_15; pfam13175
634177005002	AAA domain; Region: AAA_21; pfam13304
634177005003	AAA domain; Region: AAA_21; pfam13304
634177005004	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
634177005005	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634177005006	Transposase domain (DUF772); Region: DUF772; pfam05598
634177005007	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177005008	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177005009	Bpu10I restriction endonuclease; Region: RE_Bpu10I; pfam09549
634177005010	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177005011	S-adenosylmethionine binding site [chemical binding]; other site
634177005012	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177005013	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177005014	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177005015	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177005016	HsdM N-terminal domain; Region: HsdM_N; pfam12161
634177005017	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
634177005018	Transposase; Region: DEDD_Tnp_IS110; pfam01548
634177005019	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
634177005020	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
634177005021	Methyltransferase domain; Region: Methyltransf_26; pfam13659
634177005022	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
634177005023	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
634177005024	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
634177005025	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
634177005026	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
634177005027	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634177005028	ATP binding site [chemical binding]; other site
634177005029	putative Mg++ binding site [ion binding]; other site
634177005030	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634177005031	nucleotide binding region [chemical binding]; other site
634177005032	ATP-binding site [chemical binding]; other site
634177005033	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
634177005034	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177005035	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177005036	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177005037	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177005038	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
634177005039	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
634177005040	aldolase II superfamily protein; Provisional; Region: PRK07044
634177005041	intersubunit interface [polypeptide binding]; other site
634177005042	active site
634177005043	Zn2+ binding site [ion binding]; other site
634177005044	Amidinotransferase; Region: Amidinotransf; cl19186
634177005045	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177005046	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177005047	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
634177005048	dimerization interface [polypeptide binding]; other site
634177005049	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
634177005050	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
634177005051	substrate binding pocket [chemical binding]; other site
634177005052	membrane-bound complex binding site; other site
634177005053	hinge residues; other site
634177005054	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
634177005055	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634177005056	dimer interface [polypeptide binding]; other site
634177005057	conserved gate region; other site
634177005058	putative PBP binding loops; other site
634177005059	ABC-ATPase subunit interface; other site
634177005060	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
634177005061	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177005062	Walker A/P-loop; other site
634177005063	ATP binding site [chemical binding]; other site
634177005064	Q-loop/lid; other site
634177005065	ABC transporter signature motif; other site
634177005066	Walker B; other site
634177005067	D-loop; other site
634177005068	H-loop/switch region; other site
634177005069	putative phosphoketolase; Provisional; Region: PRK05261
634177005070	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
634177005071	TPP-binding site; other site
634177005072	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
634177005073	XFP C-terminal domain; Region: XFP_C; pfam09363
634177005074	Acetokinase family; Region: Acetate_kinase; cl17229
634177005075	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
634177005076	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
634177005077	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
634177005078	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
634177005079	active site lid residues [active]
634177005080	substrate binding pocket [chemical binding]; other site
634177005081	catalytic residues [active]
634177005082	substrate-Mg2+ binding site; other site
634177005083	aspartate-rich region 1; other site
634177005084	aspartate-rich region 2; other site
634177005085	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
634177005086	substrate binding pocket [chemical binding]; other site
634177005087	substrate-Mg2+ binding site; other site
634177005088	aspartate-rich region 1; other site
634177005089	aspartate-rich region 2; other site
634177005090	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
634177005091	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
634177005092	active site
634177005093	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634177005094	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
634177005095	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
634177005096	putative NADP binding site [chemical binding]; other site
634177005097	putative substrate binding site [chemical binding]; other site
634177005098	active site
634177005099	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
634177005100	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
634177005101	prephenate dehydrogenase; Validated; Region: PRK08507
634177005102	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177005103	DNA repair protein RadA; Provisional; Region: PRK11823
634177005104	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
634177005105	Walker A motif; other site
634177005106	ATP binding site [chemical binding]; other site
634177005107	Walker B motif; other site
634177005108	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
634177005109	Uncharacterized conserved protein [Function unknown]; Region: COG1739
634177005110	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
634177005111	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
634177005112	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
634177005113	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
634177005114	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
634177005115	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
634177005116	homopentamer interface [polypeptide binding]; other site
634177005117	active site
634177005118	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
634177005119	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
634177005120	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
634177005121	dimerization interface [polypeptide binding]; other site
634177005122	active site
634177005123	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
634177005124	Lumazine binding domain; Region: Lum_binding; pfam00677
634177005125	Lumazine binding domain; Region: Lum_binding; pfam00677
634177005126	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
634177005127	catalytic motif [active]
634177005128	Zn binding site [ion binding]; other site
634177005129	RibD C-terminal domain; Region: RibD_C; cl17279
634177005130	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
634177005131	amphipathic channel; other site
634177005132	Asn-Pro-Ala signature motifs; other site
634177005133	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
634177005134	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
634177005135	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
634177005136	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
634177005137	ATP binding site [chemical binding]; other site
634177005138	substrate interface [chemical binding]; other site
634177005139	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
634177005140	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
634177005141	Bacterial SH3 domain; Region: SH3_4; pfam06347
634177005142	Bacterial SH3 domain; Region: SH3_4; pfam06347
634177005143	pyruvate kinase; Provisional; Region: PRK06247
634177005144	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
634177005145	domain interfaces; other site
634177005146	active site
634177005147	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951
634177005148	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177005149	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177005150	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
634177005151	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177005152	Walker A/P-loop; other site
634177005153	ATP binding site [chemical binding]; other site
634177005154	Q-loop/lid; other site
634177005155	ABC transporter signature motif; other site
634177005156	Walker B; other site
634177005157	D-loop; other site
634177005158	H-loop/switch region; other site
634177005159	Permease; Region: Permease; pfam02405
634177005160	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177005161	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
634177005162	putative substrate translocation pore; other site
634177005163	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
634177005164	Guanylate kinase; Region: Guanylate_kin; pfam00625
634177005165	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
634177005166	catalytic site [active]
634177005167	G-X2-G-X-G-K; other site
634177005168	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177005169	short chain dehydrogenase; Provisional; Region: PRK07024
634177005170	NAD(P) binding site [chemical binding]; other site
634177005171	active site
634177005172	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
634177005173	cytochrome b; Provisional; Region: CYTB; MTH00145
634177005174	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
634177005175	Qi binding site; other site
634177005176	intrachain domain interface; other site
634177005177	interchain domain interface [polypeptide binding]; other site
634177005178	heme bH binding site [chemical binding]; other site
634177005179	heme bL binding site [chemical binding]; other site
634177005180	Qo binding site; other site
634177005181	interchain domain interface [polypeptide binding]; other site
634177005182	intrachain domain interface; other site
634177005183	Qi binding site; other site
634177005184	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
634177005185	Qo binding site; other site
634177005186	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
634177005187	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
634177005188	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
634177005189	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634177005190	putative oxidoreductase; Provisional; Region: PRK11579
634177005191	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
634177005192	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
634177005193	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
634177005194	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158
634177005195	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
634177005196	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634177005197	active site
634177005198	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
634177005199	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
634177005200	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
634177005201	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
634177005202	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
634177005203	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
634177005204	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
634177005205	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
634177005206	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
634177005207	purine monophosphate binding site [chemical binding]; other site
634177005208	dimer interface [polypeptide binding]; other site
634177005209	putative catalytic residues [active]
634177005210	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
634177005211	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
634177005212	homodimer interface [polypeptide binding]; other site
634177005213	substrate-cofactor binding pocket; other site
634177005214	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177005215	catalytic residue [active]
634177005216	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
634177005217	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
634177005218	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
634177005219	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
634177005220	PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524
634177005221	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
634177005222	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
634177005223	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
634177005224	dimerization domain swap beta strand [polypeptide binding]; other site
634177005225	regulatory protein interface [polypeptide binding]; other site
634177005226	active site
634177005227	regulatory phosphorylation site [posttranslational modification]; other site
634177005228	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
634177005229	active pocket/dimerization site; other site
634177005230	active site
634177005231	phosphorylation site [posttranslational modification]
634177005232	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
634177005233	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
634177005234	Hpr binding site; other site
634177005235	active site
634177005236	homohexamer subunit interaction site [polypeptide binding]; other site
634177005237	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
634177005238	homotrimer interaction site [polypeptide binding]; other site
634177005239	putative active site [active]
634177005240	YGGT family; Region: YGGT; pfam02325
634177005241	Protein of unknown function (DUF2501); Region: DUF2501; cl08197
634177005242	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
634177005243	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
634177005244	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634177005245	active site
634177005246	motif I; other site
634177005247	motif II; other site
634177005248	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
634177005249	substrate binding site [chemical binding]; other site
634177005250	active site
634177005251	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
634177005252	active site
634177005253	dimer interface [polypeptide binding]; other site
634177005254	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
634177005255	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
634177005256	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
634177005257	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
634177005258	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
634177005259	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
634177005260	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
634177005261	Ligand binding site [chemical binding]; other site
634177005262	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
634177005263	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177005264	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
634177005265	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
634177005266	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
634177005267	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
634177005268	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634177005269	FeS/SAM binding site; other site
634177005270	HemN C-terminal domain; Region: HemN_C; pfam06969
634177005271	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
634177005272	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
634177005273	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
634177005274	ligand binding site [chemical binding]; other site
634177005275	flexible hinge region; other site
634177005276	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
634177005277	putative switch regulator; other site
634177005278	non-specific DNA interactions [nucleotide binding]; other site
634177005279	DNA binding site [nucleotide binding]
634177005280	sequence specific DNA binding site [nucleotide binding]; other site
634177005281	putative cAMP binding site [chemical binding]; other site
634177005282	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
634177005283	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
634177005284	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
634177005285	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
634177005286	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
634177005287	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
634177005288	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634177005289	FeS/SAM binding site; other site
634177005290	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
634177005291	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
634177005292	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634177005293	HAMP domain; Region: HAMP; pfam00672
634177005294	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634177005295	dimer interface [polypeptide binding]; other site
634177005296	phosphorylation site [posttranslational modification]
634177005297	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177005298	ATP binding site [chemical binding]; other site
634177005299	Mg2+ binding site [ion binding]; other site
634177005300	G-X-G motif; other site
634177005301	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634177005302	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177005303	active site
634177005304	phosphorylation site [posttranslational modification]
634177005305	intermolecular recognition site; other site
634177005306	dimerization interface [polypeptide binding]; other site
634177005307	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634177005308	DNA binding site [nucleotide binding]
634177005309	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
634177005310	dimer interface [polypeptide binding]; other site
634177005311	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
634177005312	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
634177005313	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
634177005314	nucleotide binding site [chemical binding]; other site
634177005315	chaperone protein DnaJ; Provisional; Region: PRK10767
634177005316	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
634177005317	HSP70 interaction site [polypeptide binding]; other site
634177005318	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
634177005319	substrate binding site [polypeptide binding]; other site
634177005320	dimer interface [polypeptide binding]; other site
634177005321	dihydrodipicolinate reductase; Provisional; Region: PRK00048
634177005322	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
634177005323	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
634177005324	S-adenosylmethionine synthetase; Validated; Region: PRK05250
634177005325	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
634177005326	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
634177005327	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
634177005328	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
634177005329	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177005330	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
634177005331	NAD(P) binding site [chemical binding]; other site
634177005332	active site
634177005333	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
634177005334	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
634177005335	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
634177005336	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
634177005337	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
634177005338	putative ribose interaction site [chemical binding]; other site
634177005339	putative ADP binding site [chemical binding]; other site
634177005340	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634177005341	active site
634177005342	nucleotide binding site [chemical binding]; other site
634177005343	HIGH motif; other site
634177005344	KMSKS motif; other site
634177005345	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
634177005346	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177005347	putative substrate translocation pore; other site
634177005348	hypothetical protein; Validated; Region: PRK00029
634177005349	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
634177005350	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
634177005351	substrate binding site [chemical binding]; other site
634177005352	oxyanion hole (OAH) forming residues; other site
634177005353	trimer interface [polypeptide binding]; other site
634177005354	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
634177005355	Flavin Reductases; Region: FlaRed; cl00801
634177005356	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
634177005357	metal binding site 2 [ion binding]; metal-binding site
634177005358	putative DNA binding helix; other site
634177005359	metal binding site 1 [ion binding]; metal-binding site
634177005360	dimer interface [polypeptide binding]; other site
634177005361	structural Zn2+ binding site [ion binding]; other site
634177005362	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
634177005363	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177005364	putative substrate translocation pore; other site
634177005365	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
634177005366	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
634177005367	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
634177005368	substrate binding site [chemical binding]; other site
634177005369	active site
634177005370	catalytic residues [active]
634177005371	heterodimer interface [polypeptide binding]; other site
634177005372	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
634177005373	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177005374	catalytic residue [active]
634177005375	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
634177005376	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
634177005377	Cl binding site [ion binding]; other site
634177005378	oligomer interface [polypeptide binding]; other site
634177005379	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634177005380	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
634177005381	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634177005382	Vi polysaccharide export protein VexA; Provisional; Region: PRK15175
634177005383	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
634177005384	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; cl19952
634177005385	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; cl19952
634177005386	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634177005387	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177005388	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634177005389	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634177005390	zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005
634177005391	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634177005392	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634177005393	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634177005394	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634177005395	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634177005396	Transposase; Region: HTH_Tnp_1; pfam01527
634177005397	Transposase, Mutator family; Region: Transposase_mut; pfam00872
634177005398	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
634177005399	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
634177005400	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634177005401	Transposase domain (DUF772); Region: DUF772; pfam05598
634177005402	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634177005403	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177005404	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
634177005405	Transposase domain (DUF772); Region: DUF772; pfam05598
634177005406	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177005407	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177005408	Transposase, Mutator family; Region: Transposase_mut; pfam00872
634177005409	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
634177005410	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
634177005411	trimer interface [polypeptide binding]; other site
634177005412	active site
634177005413	substrate binding site [chemical binding]; other site
634177005414	CoA binding site [chemical binding]; other site
634177005415	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177005416	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177005417	potential frameshift: common BLAST hit: gi|258542502|ref|YP_003187935.1| transposase
634177005418	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177005419	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177005420	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634177005421	Transposase domain (DUF772); Region: DUF772; pfam05598
634177005422	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177005423	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177005424	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177005425	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177005426	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634177005427	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177005428	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177005429	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
634177005430	Transposase domain (DUF772); Region: DUF772; pfam05598
634177005431	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177005432	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177005433	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; cl19952
634177005434	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177005435	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177005436	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177005437	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177005438	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
634177005439	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
634177005440	NAD binding site [chemical binding]; other site
634177005441	homodimer interface [polypeptide binding]; other site
634177005442	active site
634177005443	substrate binding site [chemical binding]; other site
634177005444	potential frameshift: common BLAST hit: gi|258542502|ref|YP_003187935.1| transposase
634177005445	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177005446	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177005447	potential frameshift: common BLAST hit: gi|258513050|ref|YP_003189307.1| transposase
634177005448	Transposase domain (DUF772); Region: DUF772; pfam05598
634177005449	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177005450	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177005451	Transposase domain (DUF772); Region: DUF772; pfam05598
634177005452	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
634177005453	dimerization interface [polypeptide binding]; other site
634177005454	putative active cleft [active]
634177005455	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
634177005456	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
634177005457	Walker A/P-loop; other site
634177005458	ATP binding site [chemical binding]; other site
634177005459	Q-loop/lid; other site
634177005460	ABC transporter signature motif; other site
634177005461	Walker B; other site
634177005462	D-loop; other site
634177005463	H-loop/switch region; other site
634177005464	Chain length determinant protein; Region: Wzz; cl19730
634177005465	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524
634177005466	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
634177005467	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
634177005468	potential frameshift: common BLAST hit: gi|28558854|ref|NP_788114.1| putative transposase
634177005469	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
634177005470	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634177005471	ABC-2 type transporter; Region: ABC2_membrane; cl17235
634177005472	transcription termination factor Rho; Provisional; Region: rho; PRK09376
634177005473	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
634177005474	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
634177005475	RNA binding site [nucleotide binding]; other site
634177005476	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
634177005477	multimer interface [polypeptide binding]; other site
634177005478	Walker A motif; other site
634177005479	ATP binding site [chemical binding]; other site
634177005480	Walker B motif; other site
634177005481	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
634177005482	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
634177005483	NADP binding site [chemical binding]; other site
634177005484	dimer interface [polypeptide binding]; other site
634177005485	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
634177005486	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
634177005487	DNA binding site [nucleotide binding]
634177005488	active site
634177005489	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
634177005490	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
634177005491	trmE is a tRNA modification GTPase; Region: trmE; cd04164
634177005492	G1 box; other site
634177005493	GTP/Mg2+ binding site [chemical binding]; other site
634177005494	Switch I region; other site
634177005495	G2 box; other site
634177005496	Switch II region; other site
634177005497	G3 box; other site
634177005498	G4 box; other site
634177005499	G5 box; other site
634177005500	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
634177005501	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
634177005502	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
634177005503	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
634177005504	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
634177005505	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
634177005506	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634177005507	P-loop; other site
634177005508	Magnesium ion binding site [ion binding]; other site
634177005509	ParB-like nuclease domain; Region: ParB; smart00470
634177005510	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
634177005511	KorB domain; Region: KorB; pfam08535
634177005512	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
634177005513	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
634177005514	catalytic triad [active]
634177005515	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
634177005516	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634177005517	RNA binding surface [nucleotide binding]; other site
634177005518	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
634177005519	active site
634177005520	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177005521	S-adenosylmethionine binding site [chemical binding]; other site
634177005522	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
634177005523	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
634177005524	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
634177005525	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
634177005526	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
634177005527	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
634177005528	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
634177005529	active site
634177005530	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634177005531	catalytic core [active]
634177005532	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
634177005533	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
634177005534	nucleoside/Zn binding site; other site
634177005535	dimer interface [polypeptide binding]; other site
634177005536	catalytic motif [active]
634177005537	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
634177005538	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
634177005539	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634177005540	protein binding site [polypeptide binding]; other site
634177005541	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634177005542	protein binding site [polypeptide binding]; other site
634177005543	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
634177005544	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
634177005545	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
634177005546	homodimer interface [polypeptide binding]; other site
634177005547	NADP binding site [chemical binding]; other site
634177005548	substrate binding site [chemical binding]; other site
634177005549	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
634177005550	FAD binding site [chemical binding]; other site
634177005551	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
634177005552	dimer interface [polypeptide binding]; other site
634177005553	ADP-ribose binding site [chemical binding]; other site
634177005554	active site
634177005555	nudix motif; other site
634177005556	metal binding site [ion binding]; metal-binding site
634177005557	major facilitator superfamily transporter; Provisional; Region: PRK05122
634177005558	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177005559	putative substrate translocation pore; other site
634177005560	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
634177005561	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
634177005562	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
634177005563	Ligand binding site; other site
634177005564	Putative Catalytic site; other site
634177005565	DXD motif; other site
634177005566	Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751
634177005567	Trehalase; Region: Trehalase; cl17346
634177005568	Putative modulator of DNA gyrase; Region: PmbA_TldD; cl19356
634177005569	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
634177005570	active site
634177005571	hydrophilic channel; other site
634177005572	dimerization interface [polypeptide binding]; other site
634177005573	catalytic residues [active]
634177005574	active site lid [active]
634177005575	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
634177005576	hypothetical protein; Validated; Region: PRK09104
634177005577	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
634177005578	metal binding site [ion binding]; metal-binding site
634177005579	putative dimer interface [polypeptide binding]; other site
634177005580	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
634177005581	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
634177005582	active site
634177005583	dimer interface [polypeptide binding]; other site
634177005584	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
634177005585	active site
634177005586	Protein of unknown function (DUF721); Region: DUF721; pfam05258
634177005587	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
634177005588	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
634177005589	minor groove reading motif; other site
634177005590	helix-hairpin-helix signature motif; other site
634177005591	substrate binding pocket [chemical binding]; other site
634177005592	active site
634177005593	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
634177005594	DNA binding and oxoG recognition site [nucleotide binding]
634177005595	ferrochelatase; Reviewed; Region: hemH; PRK00035
634177005596	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
634177005597	C-terminal domain interface [polypeptide binding]; other site
634177005598	active site
634177005599	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
634177005600	active site
634177005601	N-terminal domain interface [polypeptide binding]; other site
634177005602	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
634177005603	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
634177005604	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634177005605	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
634177005606	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
634177005607	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
634177005608	carboxyltransferase (CT) interaction site; other site
634177005609	biotinylation site [posttranslational modification]; other site
634177005610	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
634177005611	trimer interface [polypeptide binding]; other site
634177005612	active site
634177005613	dimer interface [polypeptide binding]; other site
634177005614	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
634177005615	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
634177005616	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
634177005617	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
634177005618	dimer interface [polypeptide binding]; other site
634177005619	active site
634177005620	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
634177005621	catalytic residues [active]
634177005622	substrate binding site [chemical binding]; other site
634177005623	CopC domain; Region: CopC; cl01012
634177005624	CcmB protein; Region: CcmB; cl17444
634177005625	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
634177005626	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177005627	Walker A/P-loop; other site
634177005628	ATP binding site [chemical binding]; other site
634177005629	Q-loop/lid; other site
634177005630	ABC transporter signature motif; other site
634177005631	Walker B; other site
634177005632	D-loop; other site
634177005633	H-loop/switch region; other site
634177005634	aconitate hydratase; Validated; Region: PRK09277
634177005635	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
634177005636	substrate binding site [chemical binding]; other site
634177005637	ligand binding site [chemical binding]; other site
634177005638	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
634177005639	substrate binding site [chemical binding]; other site
634177005640	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177005641	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177005642	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
634177005643	putative effector binding pocket; other site
634177005644	dimerization interface [polypeptide binding]; other site
634177005645	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177005646	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
634177005647	Walker A motif; other site
634177005648	ATP binding site [chemical binding]; other site
634177005649	Walker B motif; other site
634177005650	arginine finger; other site
634177005651	Sm and related proteins; Region: Sm_like; cl00259
634177005652	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
634177005653	putative oligomer interface [polypeptide binding]; other site
634177005654	putative RNA binding site [nucleotide binding]; other site
634177005655	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
634177005656	NusA N-terminal domain; Region: NusA_N; pfam08529
634177005657	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
634177005658	RNA binding site [nucleotide binding]; other site
634177005659	homodimer interface [polypeptide binding]; other site
634177005660	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
634177005661	G-X-X-G motif; other site
634177005662	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
634177005663	G-X-X-G motif; other site
634177005664	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
634177005665	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
634177005666	hypothetical protein; Provisional; Region: PRK09190
634177005667	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
634177005668	putative RNA binding cleft [nucleotide binding]; other site
634177005669	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
634177005670	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
634177005671	translation initiation factor IF-2; Validated; Region: infB; PRK05306
634177005672	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
634177005673	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
634177005674	G1 box; other site
634177005675	putative GEF interaction site [polypeptide binding]; other site
634177005676	GTP/Mg2+ binding site [chemical binding]; other site
634177005677	Switch I region; other site
634177005678	G2 box; other site
634177005679	G3 box; other site
634177005680	Switch II region; other site
634177005681	G4 box; other site
634177005682	G5 box; other site
634177005683	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
634177005684	Translation-initiation factor 2; Region: IF-2; pfam11987
634177005685	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
634177005686	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
634177005687	mce related protein; Region: MCE; pfam02470
634177005688	CcdB protein; Region: CcdB; cl03380
634177005689	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
634177005690	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
634177005691	RNA binding site [nucleotide binding]; other site
634177005692	active site
634177005693	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
634177005694	16S/18S rRNA binding site [nucleotide binding]; other site
634177005695	S13e-L30e interaction site [polypeptide binding]; other site
634177005696	25S rRNA binding site [nucleotide binding]; other site
634177005697	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
634177005698	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
634177005699	RNase E interface [polypeptide binding]; other site
634177005700	trimer interface [polypeptide binding]; other site
634177005701	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
634177005702	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
634177005703	RNase E interface [polypeptide binding]; other site
634177005704	trimer interface [polypeptide binding]; other site
634177005705	active site
634177005706	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
634177005707	putative nucleic acid binding region [nucleotide binding]; other site
634177005708	G-X-X-G motif; other site
634177005709	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
634177005710	RNA binding site [nucleotide binding]; other site
634177005711	domain interface; other site
634177005712	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
634177005713	phosphate binding site [ion binding]; other site
634177005714	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
634177005715	active site
634177005716	dimerization interface [polypeptide binding]; other site
634177005717	ribonuclease PH; Reviewed; Region: rph; PRK00173
634177005718	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
634177005719	oligomer interface [polypeptide binding]; other site
634177005720	RNA binding site [nucleotide binding]; other site
634177005721	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
634177005722	HrcA protein C terminal domain; Region: HrcA; pfam01628
634177005723	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
634177005724	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
634177005725	active site
634177005726	catalytic tetrad [active]
634177005727	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
634177005728	Transglycosylase; Region: Transgly; pfam00912
634177005729	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
634177005730	peptide chain release factor 2; Provisional; Region: PRK07342
634177005731	This domain is found in peptide chain release factors; Region: PCRF; smart00937
634177005732	RF-1 domain; Region: RF-1; pfam00472
634177005733	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
634177005734	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
634177005735	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634177005736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177005737	active site
634177005738	phosphorylation site [posttranslational modification]
634177005739	intermolecular recognition site; other site
634177005740	dimerization interface [polypeptide binding]; other site
634177005741	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634177005742	DNA binding site [nucleotide binding]
634177005743	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
634177005744	dimerization interface [polypeptide binding]; other site
634177005745	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634177005746	dimer interface [polypeptide binding]; other site
634177005747	phosphorylation site [posttranslational modification]
634177005748	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177005749	ATP binding site [chemical binding]; other site
634177005750	Mg2+ binding site [ion binding]; other site
634177005751	G-X-G motif; other site
634177005752	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
634177005753	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
634177005754	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
634177005755	putative FMN binding site [chemical binding]; other site
634177005756	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
634177005757	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
634177005758	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634177005759	Coenzyme A binding pocket [chemical binding]; other site
634177005760	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
634177005761	CPxP  motif; other site
634177005762	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
634177005763	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
634177005764	metal binding site 2 [ion binding]; metal-binding site
634177005765	putative DNA binding helix; other site
634177005766	metal binding site 1 [ion binding]; metal-binding site
634177005767	dimer interface [polypeptide binding]; other site
634177005768	structural Zn2+ binding site [ion binding]; other site
634177005769	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
634177005770	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
634177005771	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
634177005772	putative active site [active]
634177005773	catalytic triad [active]
634177005774	putative dimer interface [polypeptide binding]; other site
634177005775	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634177005776	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634177005777	non-specific DNA binding site [nucleotide binding]; other site
634177005778	salt bridge; other site
634177005779	sequence-specific DNA binding site [nucleotide binding]; other site
634177005780	Tyrosine phosphatase family; Region: Y_phosphatase3; cl19170
634177005781	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
634177005782	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
634177005783	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
634177005784	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
634177005785	L-aspartate oxidase; Provisional; Region: PRK06175
634177005786	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
634177005787	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
634177005788	putative SdhC subunit interface [polypeptide binding]; other site
634177005789	putative proximal heme binding site [chemical binding]; other site
634177005790	putative Iron-sulfur protein interface [polypeptide binding]; other site
634177005791	putative proximal quinone binding site; other site
634177005792	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
634177005793	Iron-sulfur protein interface; other site
634177005794	proximal quinone binding site [chemical binding]; other site
634177005795	SdhD (CybS) interface [polypeptide binding]; other site
634177005796	proximal heme binding site [chemical binding]; other site
634177005797	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
634177005798	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
634177005799	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
634177005800	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
634177005801	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
634177005802	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
634177005803	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
634177005804	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
634177005805	Predicted ATPase [General function prediction only]; Region: COG1485
634177005806	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
634177005807	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
634177005808	TPP-binding site [chemical binding]; other site
634177005809	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
634177005810	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
634177005811	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634177005812	E3 interaction surface; other site
634177005813	lipoyl attachment site [posttranslational modification]; other site
634177005814	e3 binding domain; Region: E3_binding; pfam02817
634177005815	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
634177005816	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634177005817	E3 interaction surface; other site
634177005818	lipoyl attachment site [posttranslational modification]; other site
634177005819	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
634177005820	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177005821	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634177005822	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
634177005823	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
634177005824	PAS domain; Region: PAS_9; pfam13426
634177005825	putative active site [active]
634177005826	heme pocket [chemical binding]; other site
634177005827	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
634177005828	metal binding site [ion binding]; metal-binding site
634177005829	active site
634177005830	I-site; other site
634177005831	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
634177005832	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
634177005833	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
634177005834	putative active site [active]
634177005835	heme pocket [chemical binding]; other site
634177005836	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
634177005837	metal binding site [ion binding]; metal-binding site
634177005838	active site
634177005839	I-site; other site
634177005840	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
634177005841	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
634177005842	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
634177005843	G1 box; other site
634177005844	GTP/Mg2+ binding site [chemical binding]; other site
634177005845	Switch I region; other site
634177005846	G2 box; other site
634177005847	G3 box; other site
634177005848	Switch II region; other site
634177005849	G4 box; other site
634177005850	G5 box; other site
634177005851	Nucleoside recognition; Region: Gate; pfam07670
634177005852	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
634177005853	Nucleoside recognition; Region: Gate; pfam07670
634177005854	FeoA domain; Region: FeoA; pfam04023
634177005855	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
634177005856	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
634177005857	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
634177005858	conserved cys residue [active]
634177005859	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
634177005860	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
634177005861	active site
634177005862	SAM binding site [chemical binding]; other site
634177005863	homodimer interface [polypeptide binding]; other site
634177005864	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
634177005865	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
634177005866	active site
634177005867	putative homodimer interface [polypeptide binding]; other site
634177005868	SAM binding site [chemical binding]; other site
634177005869	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177005870	S-adenosylmethionine binding site [chemical binding]; other site
634177005871	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
634177005872	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
634177005873	active site
634177005874	SAM binding site [chemical binding]; other site
634177005875	homodimer interface [polypeptide binding]; other site
634177005876	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
634177005877	active site
634177005878	SAM binding site [chemical binding]; other site
634177005879	homodimer interface [polypeptide binding]; other site
634177005880	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
634177005881	precorrin-3B synthase; Region: CobG; TIGR02435
634177005882	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
634177005883	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
634177005884	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
634177005885	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
634177005886	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
634177005887	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
634177005888	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
634177005889	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
634177005890	dimer interface [polypeptide binding]; other site
634177005891	[2Fe-2S] cluster binding site [ion binding]; other site
634177005892	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
634177005893	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
634177005894	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
634177005895	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
634177005896	NADP binding site [chemical binding]; other site
634177005897	dimer interface [polypeptide binding]; other site
634177005898	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
634177005899	dimer interface [polypeptide binding]; other site
634177005900	FMN binding site [chemical binding]; other site
634177005901	NADPH bind site [chemical binding]; other site
634177005902	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
634177005903	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
634177005904	homodimer interface [polypeptide binding]; other site
634177005905	substrate-cofactor binding pocket; other site
634177005906	catalytic residue [active]
634177005907	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
634177005908	ThiC-associated domain; Region: ThiC-associated; pfam13667
634177005909	ThiC family; Region: ThiC; pfam01964
634177005910	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
634177005911	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634177005912	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
634177005913	active site
634177005914	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634177005915	active site
634177005916	DNA binding site [nucleotide binding]
634177005917	Int/Topo IB signature motif; other site
634177005918	ScpA/B protein; Region: ScpA_ScpB; cl00598
634177005919	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
634177005920	Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544
634177005921	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
634177005922	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634177005923	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634177005924	Sulfate transporter family; Region: Sulfate_transp; cl19250
634177005925	xanthine permease; Region: pbuX; TIGR03173
634177005926	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177005927	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634177005928	putative substrate translocation pore; other site
634177005929	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
634177005930	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
634177005931	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
634177005932	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
634177005933	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
634177005934	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
634177005935	generic binding surface II; other site
634177005936	generic binding surface I; other site
634177005937	Helix-turn-helix domain; Region: HTH_17; pfam12728
634177005938	Protein of unknown function (DUF3137); Region: DUF3137; pfam11335
634177005939	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
634177005940	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
634177005941	putative deacylase active site [active]
634177005942	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177005943	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
634177005944	NAD(P) binding site [chemical binding]; other site
634177005945	active site
634177005946	amidophosphoribosyltransferase; Provisional; Region: PRK09123
634177005947	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
634177005948	active site
634177005949	tetramer interface [polypeptide binding]; other site
634177005950	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634177005951	active site
634177005952	Colicin V production protein; Region: Colicin_V; pfam02674
634177005953	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
634177005954	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
634177005955	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
634177005956	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
634177005957	substrate binding pocket [chemical binding]; other site
634177005958	dimer interface [polypeptide binding]; other site
634177005959	inhibitor binding site; inhibition site
634177005960	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
634177005961	B12 binding site [chemical binding]; other site
634177005962	cobalt ligand [ion binding]; other site
634177005963	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
634177005964	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
634177005965	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
634177005966	putative active site [active]
634177005967	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634177005968	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177005969	Walker A/P-loop; other site
634177005970	ATP binding site [chemical binding]; other site
634177005971	Q-loop/lid; other site
634177005972	ABC transporter signature motif; other site
634177005973	Walker B; other site
634177005974	D-loop; other site
634177005975	H-loop/switch region; other site
634177005976	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
634177005977	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634177005978	HlyD family secretion protein; Region: HlyD_3; pfam13437
634177005979	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
634177005980	Sel1-like repeats; Region: SEL1; smart00671
634177005981	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
634177005982	Sel1-like repeats; Region: SEL1; smart00671
634177005983	Sel1-like repeats; Region: SEL1; smart00671
634177005984	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
634177005985	Sel1-like repeats; Region: SEL1; smart00671
634177005986	Sel1-like repeats; Region: SEL1; smart00671
634177005987	Sel1-like repeats; Region: SEL1; smart00671
634177005988	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
634177005989	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634177005990	active site
634177005991	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
634177005992	putative ADP-binding pocket [chemical binding]; other site
634177005993	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634177005994	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
634177005995	dimer interface [polypeptide binding]; other site
634177005996	substrate binding site [chemical binding]; other site
634177005997	metal binding sites [ion binding]; metal-binding site
634177005998	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
634177005999	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634177006000	ABC transporter; Region: ABC_tran_2; pfam12848
634177006001	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634177006002	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
634177006003	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
634177006004	VacJ like lipoprotein; Region: VacJ; cl01073
634177006005	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
634177006006	Stringent starvation protein B; Region: SspB; pfam04386
634177006007	fumarate hydratase; Provisional; Region: PRK15389
634177006008	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
634177006009	Fumarase C-terminus; Region: Fumerase_C; pfam05683
634177006010	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
634177006011	dimer interface [polypeptide binding]; other site
634177006012	metal binding site [ion binding]; metal-binding site
634177006013	TM2 domain; Region: TM2; pfam05154
634177006014	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
634177006015	substrate binding site [chemical binding]; other site
634177006016	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
634177006017	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
634177006018	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
634177006019	epoxyqueuosine reductase; Region: TIGR00276
634177006020	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
634177006021	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
634177006022	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
634177006023	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
634177006024	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
634177006025	putative metal binding site [ion binding]; other site
634177006026	Domain of unknown function DUF59; Region: DUF59; cl00941
634177006027	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
634177006028	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
634177006029	Walker A motif; other site
634177006030	OpgC protein; Region: OpgC_C; pfam10129
634177006031	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
634177006032	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
634177006033	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634177006034	protein binding site [polypeptide binding]; other site
634177006035	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634177006036	protein binding site [polypeptide binding]; other site
634177006037	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634177006038	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
634177006039	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
634177006040	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
634177006041	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634177006042	Coenzyme A binding pocket [chemical binding]; other site
634177006043	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
634177006044	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
634177006045	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
634177006046	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
634177006047	Ligand binding site; other site
634177006048	DXD motif; other site
634177006049	polyol permease family; Region: 2A0118; TIGR00897
634177006050	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177006051	putative substrate translocation pore; other site
634177006052	paraquat-inducible protein B; Provisional; Region: PRK10807
634177006053	histidinol-phosphate aminotransferase; Provisional; Region: PRK05387
634177006054	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634177006055	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177006056	homodimer interface [polypeptide binding]; other site
634177006057	catalytic residue [active]
634177006058	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
634177006059	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
634177006060	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
634177006061	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
634177006062	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
634177006063	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
634177006064	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
634177006065	TPP-binding site [chemical binding]; other site
634177006066	dimer interface [polypeptide binding]; other site
634177006067	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
634177006068	PYR/PP interface [polypeptide binding]; other site
634177006069	dimer interface [polypeptide binding]; other site
634177006070	TPP binding site [chemical binding]; other site
634177006071	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634177006072	bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
634177006073	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
634177006074	putative active site [active]
634177006075	catalytic residue [active]
634177006076	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
634177006077	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
634177006078	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
634177006079	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
634177006080	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
634177006081	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
634177006082	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
634177006083	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
634177006084	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634177006085	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
634177006086	active site
634177006087	motif I; other site
634177006088	motif II; other site
634177006089	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
634177006090	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634177006091	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
634177006092	active site
634177006093	motif I; other site
634177006094	motif II; other site
634177006095	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
634177006096	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
634177006097	putative active site [active]
634177006098	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
634177006099	tetramer (dimer of dimers) interface [polypeptide binding]; other site
634177006100	active site
634177006101	dimer interface [polypeptide binding]; other site
634177006102	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
634177006103	AAA domain; Region: AAA_33; pfam13671
634177006104	ATP-binding site [chemical binding]; other site
634177006105	Gluconate-6-phosphate binding site [chemical binding]; other site
634177006106	Low molecular weight phosphatase family; Region: LMWPc; cd00115
634177006107	active site
634177006108	Phosphotransferase enzyme family; Region: APH; pfam01636
634177006109	Fructosamine kinase; Region: Fructosamin_kin; cl17579
634177006110	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
634177006111	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
634177006112	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
634177006113	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
634177006114	dimer interface [polypeptide binding]; other site
634177006115	decamer (pentamer of dimers) interface [polypeptide binding]; other site
634177006116	catalytic triad [active]
634177006117	peroxidatic and resolving cysteines [active]
634177006118	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177006119	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
634177006120	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
634177006121	dimerization interface [polypeptide binding]; other site
634177006122	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
634177006123	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634177006124	binding surface
634177006125	TPR repeat; Region: TPR_11; pfam13414
634177006126	TPR motif; other site
634177006127	hypothetical protein; Validated; Region: PRK09039
634177006128	HemX; Region: HemX; cl19375
634177006129	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
634177006130	ligand binding site [chemical binding]; other site
634177006131	Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442
634177006132	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
634177006133	ligand binding site [chemical binding]; other site
634177006134	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
634177006135	active site
634177006136	dimerization interface [polypeptide binding]; other site
634177006137	elongation factor P; Validated; Region: PRK00529
634177006138	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
634177006139	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
634177006140	RNA binding site [nucleotide binding]; other site
634177006141	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
634177006142	RNA binding site [nucleotide binding]; other site
634177006143	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634177006144	FeS/SAM binding site; other site
634177006145	Radical SAM superfamily; Region: Radical_SAM; pfam04055
634177006146	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
634177006147	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
634177006148	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
634177006149	motif 1; other site
634177006150	dimer interface [polypeptide binding]; other site
634177006151	active site
634177006152	motif 2; other site
634177006153	motif 3; other site
634177006154	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
634177006155	thiamine phosphate binding site [chemical binding]; other site
634177006156	active site
634177006157	pyrophosphate binding site [ion binding]; other site
634177006158	Cell division protein ZapA; Region: ZapA; pfam05164
634177006159	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
634177006160	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
634177006161	putative active site [active]
634177006162	metal binding site [ion binding]; metal-binding site
634177006163	homodimer binding site [polypeptide binding]; other site
634177006164	AMP nucleosidase; Provisional; Region: PRK08292
634177006165	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
634177006166	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
634177006167	Ebola nucleoprotein; Region: Ebola_NP; pfam05505
634177006168	Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544
634177006169	Putative lysophospholipase; Region: Hydrolase_4; cl19140
634177006170	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634177006171	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
634177006172	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
634177006173	NAD(P) binding site [chemical binding]; other site
634177006174	glutamine synthetase; Provisional; Region: glnA; PRK09469
634177006175	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
634177006176	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
634177006177	Nitrogen regulatory protein P-II; Region: P-II; smart00938
634177006178	hypothetical protein; Provisional; Region: PRK08912
634177006179	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634177006180	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177006181	homodimer interface [polypeptide binding]; other site
634177006182	catalytic residue [active]
634177006183	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177006184	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
634177006185	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177006186	active site
634177006187	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
634177006188	23S rRNA interface [nucleotide binding]; other site
634177006189	L3 interface [polypeptide binding]; other site
634177006190	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
634177006191	DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864
634177006192	active site
634177006193	substrate binding site [chemical binding]; other site
634177006194	Mg2+ binding site [ion binding]; other site
634177006195	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
634177006196	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
634177006197	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
634177006198	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
634177006199	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
634177006200	Phage protein GP46; Region: GP46; cl01814
634177006201	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410
634177006202	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
634177006203	DNA circularisation protein N-terminus; Region: DNA_circ_N; cl19561
634177006204	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
634177006205	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634177006206	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634177006207	catalytic residue [active]
634177006208	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
634177006209	Phage tail tube protein; Region: Tail_tube; pfam10618
634177006210	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
634177006211	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
634177006212	Protein of unknown function (DUF2635); Region: DUF2635; pfam10948
634177006213	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
634177006214	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
634177006215	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
634177006216	oligomerization interface [polypeptide binding]; other site
634177006217	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
634177006218	Phage capsid family; Region: Phage_capsid; pfam05065
634177006219	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
634177006220	Phage portal protein; Region: Phage_portal; pfam04860
634177006221	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
634177006222	Phage Terminase; Region: Terminase_1; cl19862
634177006223	Phage terminase, small subunit; Region: Terminase_4; pfam05119
634177006224	DNA-binding transcriptional regulator Cro; Region: P22_Cro; cl18770
634177006225	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
634177006226	active site
634177006227	Toprim domain; Region: Toprim_3; pfam13362
634177006228	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634177006229	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634177006230	non-specific DNA binding site [nucleotide binding]; other site
634177006231	salt bridge; other site
634177006232	sequence-specific DNA binding site [nucleotide binding]; other site
634177006233	ParB-like nuclease domain; Region: ParBc; pfam02195
634177006234	plasmid partitioning protein; Provisional; Region: PRK13832
634177006235	integrase; Provisional; Region: int; PHA02601
634177006236	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
634177006237	active site
634177006238	catalytic residues [active]
634177006239	DNA binding site [nucleotide binding]
634177006240	Int/Topo IB signature motif; other site
634177006241	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
634177006242	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
634177006243	active site
634177006244	putative substrate binding pocket [chemical binding]; other site
634177006245	short chain dehydrogenase; Region: adh_short; pfam00106
634177006246	classical (c) SDRs; Region: SDR_c; cd05233
634177006247	NAD(P) binding site [chemical binding]; other site
634177006248	active site
634177006249	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
634177006250	active site
634177006251	catalytic triad [active]
634177006252	oxyanion hole [active]
634177006253	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634177006254	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634177006255	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634177006256	catalytic residue [active]
634177006257	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
634177006258	active site
634177006259	oxyanion hole [active]
634177006260	catalytic triad [active]
634177006261	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
634177006262	GTP-binding protein LepA; Provisional; Region: PRK05433
634177006263	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
634177006264	G1 box; other site
634177006265	putative GEF interaction site [polypeptide binding]; other site
634177006266	GTP/Mg2+ binding site [chemical binding]; other site
634177006267	Switch I region; other site
634177006268	G2 box; other site
634177006269	G3 box; other site
634177006270	Switch II region; other site
634177006271	G4 box; other site
634177006272	G5 box; other site
634177006273	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
634177006274	Elongation Factor G, domain II; Region: EFG_II; pfam14492
634177006275	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
634177006276	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
634177006277	Predicted transcriptional regulator [Transcription]; Region: COG2932
634177006278	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
634177006279	Catalytic site [active]
634177006280	putative internal virion protein; Provisional; Region: PHA03415
634177006281	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
634177006282	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
634177006283	ATP binding site [chemical binding]; other site
634177006284	Mg++ binding site [ion binding]; other site
634177006285	motif III; other site
634177006286	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634177006287	nucleotide binding region [chemical binding]; other site
634177006288	ATP-binding site [chemical binding]; other site
634177006289	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
634177006290	RNA binding site [nucleotide binding]; other site
634177006291	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
634177006292	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
634177006293	putative NAD(P) binding site [chemical binding]; other site
634177006294	putative substrate binding site [chemical binding]; other site
634177006295	catalytic Zn binding site [ion binding]; other site
634177006296	structural Zn binding site [ion binding]; other site
634177006297	Protein of unknown function, DUF482; Region: DUF482; pfam04339
634177006298	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
634177006299	homotrimer interaction site [polypeptide binding]; other site
634177006300	putative active site [active]
634177006301	TSCPD domain; Region: TSCPD; cl14834
634177006302	NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; cl01534
634177006303	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
634177006304	mce related protein; Region: MCE; pfam02470
634177006305	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970
634177006306	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
634177006307	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634177006308	active site
634177006309	motif I; other site
634177006310	motif II; other site
634177006311	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
634177006312	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
634177006313	active site
634177006314	homotetramer interface [polypeptide binding]; other site
634177006315	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
634177006316	hypothetical protein; Provisional; Region: PRK13682
634177006317	NAD synthetase; Reviewed; Region: nadE; PRK02628
634177006318	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
634177006319	multimer interface [polypeptide binding]; other site
634177006320	active site
634177006321	catalytic triad [active]
634177006322	protein interface 1 [polypeptide binding]; other site
634177006323	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
634177006324	homodimer interface [polypeptide binding]; other site
634177006325	NAD binding pocket [chemical binding]; other site
634177006326	ATP binding pocket [chemical binding]; other site
634177006327	Mg binding site [ion binding]; other site
634177006328	active-site loop [active]
634177006329	Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216
634177006330	DNA binding site [nucleotide binding]
634177006331	dimer interface [polypeptide binding]; other site
634177006332	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
634177006333	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
634177006334	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
634177006335	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
634177006336	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
634177006337	Cysteine-rich domain; Region: CCG; pfam02754
634177006338	Cysteine-rich domain; Region: CCG; pfam02754
634177006339	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
634177006340	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177006341	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
634177006342	putative dimerization interface [polypeptide binding]; other site
634177006343	putative substrate binding pocket [chemical binding]; other site
634177006344	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
634177006345	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
634177006346	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
634177006347	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
634177006348	Uncharacterized conserved protein [Function unknown]; Region: COG2308
634177006349	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
634177006350	Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382
634177006351	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
634177006352	Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748
634177006353	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
634177006354	Membrane fusogenic activity; Region: BMFP; pfam04380
634177006355	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
634177006356	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
634177006357	NADP binding site [chemical binding]; other site
634177006358	homopentamer interface [polypeptide binding]; other site
634177006359	substrate binding site [chemical binding]; other site
634177006360	active site
634177006361	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
634177006362	Uncharacterized conserved protein [Function unknown]; Region: COG1565
634177006363	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
634177006364	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
634177006365	ribonuclease E; Reviewed; Region: rne; PRK10811
634177006366	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
634177006367	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
634177006368	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634177006369	active site
634177006370	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634177006371	catalytic core [active]
634177006372	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
634177006373	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
634177006374	5S rRNA interface [nucleotide binding]; other site
634177006375	CTC domain interface [polypeptide binding]; other site
634177006376	L16 interface [polypeptide binding]; other site
634177006377	Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693
634177006378	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
634177006379	putative active site [active]
634177006380	catalytic residue [active]
634177006381	GTP-binding protein YchF; Reviewed; Region: PRK09601
634177006382	YchF GTPase; Region: YchF; cd01900
634177006383	G1 box; other site
634177006384	GTP/Mg2+ binding site [chemical binding]; other site
634177006385	Switch I region; other site
634177006386	G2 box; other site
634177006387	Switch II region; other site
634177006388	G3 box; other site
634177006389	G4 box; other site
634177006390	G5 box; other site
634177006391	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
634177006392	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
634177006393	putative catalytic cysteine [active]
634177006394	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
634177006395	active site
634177006396	(T/H)XGH motif; other site
634177006397	Oligomerization domain; Region: Oligomerization; pfam02410
634177006398	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
634177006399	CHAP domain; Region: CHAP; cl17642
634177006400	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
634177006401	homotrimer interaction site [polypeptide binding]; other site
634177006402	putative active site [active]
634177006403	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
634177006404	Ligand binding site; other site
634177006405	metal-binding site
634177006406	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
634177006407	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
634177006408	XdhC Rossmann domain; Region: XdhC_C; pfam13478
634177006409	Protein required for attachment to host cells; Region: Host_attach; cl02398
634177006410	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
634177006411	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
634177006412	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634177006413	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
634177006414	catalytic residues [active]
634177006415	catalytic nucleophile [active]
634177006416	Recombinase; Region: Recombinase; pfam07508
634177006417	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
634177006418	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
634177006419	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634177006420	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
634177006421	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
634177006422	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
634177006423	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
634177006424	HsdM N-terminal domain; Region: HsdM_N; pfam12161
634177006425	Methyltransferase domain; Region: Methyltransf_26; pfam13659
634177006426	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
634177006427	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
634177006428	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
634177006429	Abortive infection C-terminus; Region: Abi_C; pfam14355
634177006430	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
634177006431	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
634177006432	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634177006433	ATP binding site [chemical binding]; other site
634177006434	putative Mg++ binding site [ion binding]; other site
634177006435	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
634177006436	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634177006437	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
634177006438	catalytic residues [active]
634177006439	catalytic nucleophile [active]
634177006440	Recombinase; Region: Recombinase; pfam07508
634177006441	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
634177006442	Iron-containing redox enzyme; Region: Haem_oxygenas_2; pfam14518
634177006443	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634177006444	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634177006445	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
634177006446	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
634177006447	Walker A motif; other site
634177006448	ATP binding site [chemical binding]; other site
634177006449	Walker B motif; other site
634177006450	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
634177006451	Walker A motif; other site
634177006452	ATP binding site [chemical binding]; other site
634177006453	Walker B motif; other site
634177006454	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
634177006455	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
634177006456	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
634177006457	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
634177006458	Domain of unknown function DUF87; Region: DUF87; cl19135
634177006459	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
634177006460	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
634177006461	conjugal transfer protein TrbL; Provisional; Region: PRK13875
634177006462	conjugal transfer protein TrbF; Provisional; Region: PRK13872
634177006463	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
634177006464	VirB7 interaction site; other site
634177006465	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
634177006466	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
634177006467	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
634177006468	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
634177006469	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
634177006470	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
634177006471	EamA-like transporter family; Region: EamA; pfam00892
634177006472	EamA-like transporter family; Region: EamA; pfam00892
634177006473	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
634177006474	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
634177006475	putative C-terminal domain interface [polypeptide binding]; other site
634177006476	putative GSH binding site (G-site) [chemical binding]; other site
634177006477	putative dimer interface [polypeptide binding]; other site
634177006478	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
634177006479	putative N-terminal domain interface [polypeptide binding]; other site
634177006480	putative dimer interface [polypeptide binding]; other site
634177006481	putative substrate binding pocket (H-site) [chemical binding]; other site
634177006482	ParB-like nuclease domain; Region: ParBc; pfam02195
634177006483	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
634177006484	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844
634177006485	histone-like DNA-binding protein HU; Region: HU; cd13831
634177006486	dimer interface [polypeptide binding]; other site
634177006487	DNA binding site [nucleotide binding]
634177006488	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177006489	S-adenosylmethionine binding site [chemical binding]; other site
634177006490	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634177006491	ATP binding site [chemical binding]; other site
634177006492	putative Mg++ binding site [ion binding]; other site
634177006493	Helicase_C-like; Region: Helicase_C_4; pfam13871
634177006494	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
634177006495	active site
634177006496	metal binding site [ion binding]; metal-binding site
634177006497	interdomain interaction site; other site
634177006498	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
634177006499	Predicted periplasmic protein [Function unknown]; Region: COG3904
634177006500	Uncharacterized conserved protein [Function unknown]; Region: COG5489
634177006501	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
634177006502	Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074
634177006503	Replication initiator protein A; Region: RPA; cl19398
634177006504	DNA methylase; Region: N6_N4_Mtase; cl17433
634177006505	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
634177006506	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
634177006507	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
634177006508	Protein of unknown function (DUF736); Region: DUF736; pfam05284
634177006509	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634177006510	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634177006511	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634177006512	catalytic residue [active]
634177006513	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
634177006514	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
634177006515	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
634177006516	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634177006517	N-terminal plug; other site
634177006518	ligand-binding site [chemical binding]; other site
634177006519	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
634177006520	DNA binding residues [nucleotide binding]
634177006521	dimerization interface [polypeptide binding]; other site
634177006522	Transcriptional regulators [Transcription]; Region: FadR; COG2186
634177006523	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
634177006524	DNA-binding site [nucleotide binding]; DNA binding site
634177006525	FCD domain; Region: FCD; pfam07729
634177006526	Guanine nucleotide exchange factor synembryn; Region: Ric8; pfam10165
634177006527	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
634177006528	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177006529	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
634177006530	putative substrate binding pocket [chemical binding]; other site
634177006531	putative dimerization interface [polypeptide binding]; other site
634177006532	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
634177006533	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177006534	putative substrate translocation pore; other site
634177006535	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
634177006536	dinuclear metal binding motif [ion binding]; other site
634177006537	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
634177006538	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634177006539	HlyD family secretion protein; Region: HlyD_3; pfam13437
634177006540	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634177006541	Outer membrane efflux protein; Region: OEP; pfam02321
634177006542	Outer membrane efflux protein; Region: OEP; pfam02321
634177006543	Pirin-related protein [General function prediction only]; Region: COG1741
634177006544	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
634177006545	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
634177006546	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
634177006547	enoyl-CoA hydratase; Provisional; Region: PRK06688
634177006548	substrate binding site [chemical binding]; other site
634177006549	oxyanion hole (OAH) forming residues; other site
634177006550	trimer interface [polypeptide binding]; other site
634177006551	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
634177006552	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
634177006553	acyl-activating enzyme (AAE) consensus motif; other site
634177006554	AMP binding site [chemical binding]; other site
634177006555	active site
634177006556	CoA binding site [chemical binding]; other site
634177006557	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
634177006558	Phenylacetic acid degradation B; Region: PaaB; cl01371
634177006559	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
634177006560	Domain of unknown function DUF59; Region: DUF59; cl00941
634177006561	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
634177006562	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
634177006563	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
634177006564	FAD binding pocket [chemical binding]; other site
634177006565	conserved FAD binding motif [chemical binding]; other site
634177006566	phosphate binding motif [ion binding]; other site
634177006567	beta-alpha-beta structure motif; other site
634177006568	NAD binding pocket [chemical binding]; other site
634177006569	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634177006570	catalytic loop [active]
634177006571	iron binding site [ion binding]; other site
634177006572	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
634177006573	active site 2 [active]
634177006574	active site 1 [active]
634177006575	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
634177006576	active site
634177006577	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
634177006578	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932
634177006579	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
634177006580	active site
634177006581	Prephenate dehydratase; Region: PDT; pfam00800
634177006582	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
634177006583	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
634177006584	dimer interface [polypeptide binding]; other site
634177006585	PYR/PP interface [polypeptide binding]; other site
634177006586	TPP binding site [chemical binding]; other site
634177006587	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634177006588	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
634177006589	TPP-binding site [chemical binding]; other site
634177006590	dimer interface [polypeptide binding]; other site
634177006591	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177006592	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177006593	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
634177006594	Transposase; Region: DEDD_Tnp_IS110; pfam01548
634177006595	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
634177006596	Transposase; Region: HTH_Tnp_1; cl17663
634177006597	Winged helix-turn helix; Region: HTH_29; pfam13551
634177006598	Integrase core domain; Region: rve; pfam00665
634177006599	Integrase core domain; Region: rve_3; pfam13683
634177006600	Transposase domain (DUF772); Region: DUF772; pfam05598
634177006601	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634177006602	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177006603	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634177006604	catalytic core [active]
634177006605	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
634177006606	dimerization interface [polypeptide binding]; other site
634177006607	putative DNA binding site [nucleotide binding]; other site
634177006608	putative Zn2+ binding site [ion binding]; other site
634177006609	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
634177006610	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177006611	putative substrate translocation pore; other site
634177006612	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177006613	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177006614	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
634177006615	putative substrate binding pocket [chemical binding]; other site
634177006616	putative dimerization interface [polypeptide binding]; other site
634177006617	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177006618	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
634177006619	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
634177006620	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634177006621	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
634177006622	HlyD family secretion protein; Region: HlyD_3; pfam13437
634177006623	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634177006624	Outer membrane efflux protein; Region: OEP; pfam02321
634177006625	Outer membrane efflux protein; Region: OEP; pfam02321
634177006626	Pirin-related protein [General function prediction only]; Region: COG1741
634177006627	Pirin; Region: Pirin; pfam02678
634177006628	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177006629	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177006630	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
634177006631	putative effector binding pocket; other site
634177006632	dimerization interface [polypeptide binding]; other site
634177006633	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
634177006634	Uncharacterized conserved protein [Function unknown]; Region: COG2353
634177006635	multidrug efflux system protein MdtE; Provisional; Region: PRK09859
634177006636	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634177006637	HlyD family secretion protein; Region: HlyD_3; pfam13437
634177006638	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
634177006639	MMPL family; Region: MMPL; cl14618
634177006640	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634177006641	Outer membrane efflux protein; Region: OEP; pfam02321
634177006642	Outer membrane efflux protein; Region: OEP; pfam02321
634177006643	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634177006644	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634177006645	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177006646	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177006647	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
634177006648	putative effector binding pocket; other site
634177006649	putative dimerization interface [polypeptide binding]; other site
634177006650	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
634177006651	active site
634177006652	FMN binding site [chemical binding]; other site
634177006653	substrate binding site [chemical binding]; other site
634177006654	homotetramer interface [polypeptide binding]; other site
634177006655	catalytic residue [active]
634177006656	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
634177006657	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177006658	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
634177006659	NAD(P) binding site [chemical binding]; other site
634177006660	active site
634177006661	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
634177006662	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
634177006663	oligomeric interface; other site
634177006664	putative active site [active]
634177006665	homodimer interface [polypeptide binding]; other site
634177006666	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177006667	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177006668	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
634177006669	dimerization interface [polypeptide binding]; other site
634177006670	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
634177006671	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634177006672	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
634177006673	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
634177006674	potential frameshift: common BLAST hit: gi|162145855|ref|YP_001600313.1| transposase
634177006675	LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541
634177006676	Autoinducer binding domain; Region: Autoind_bind; pfam03472
634177006677	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
634177006678	DNA binding residues [nucleotide binding]
634177006679	dimerization interface [polypeptide binding]; other site
634177006680	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
634177006681	Prostaglandin dehydrogenases; Region: PGDH; cd05288
634177006682	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
634177006683	NAD(P) binding site [chemical binding]; other site
634177006684	substrate binding site [chemical binding]; other site
634177006685	dimer interface [polypeptide binding]; other site
634177006686	chaperone protein HchA; Provisional; Region: PRK04155
634177006687	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
634177006688	conserved cys residue [active]
634177006689	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
634177006690	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
634177006691	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
634177006692	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177006693	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177006694	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
634177006695	putative effector binding pocket; other site
634177006696	dimerization interface [polypeptide binding]; other site
634177006697	Transposase domain (DUF772); Region: DUF772; pfam05598
634177006698	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177006699	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177006700	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
634177006701	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
634177006702	putative C-terminal domain interface [polypeptide binding]; other site
634177006703	putative GSH binding site (G-site) [chemical binding]; other site
634177006704	putative dimer interface [polypeptide binding]; other site
634177006705	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
634177006706	putative N-terminal domain interface [polypeptide binding]; other site
634177006707	putative dimer interface [polypeptide binding]; other site
634177006708	putative substrate binding pocket (H-site) [chemical binding]; other site
634177006709	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177006710	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634177006711	putative substrate translocation pore; other site
634177006712	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
634177006713	transmembrane helices; other site
634177006714	Transcriptional regulators [Transcription]; Region: MarR; COG1846
634177006715	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
634177006716	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
634177006717	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177006718	Helix-turn-helix domain; Region: HTH_18; pfam12833
634177006719	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634177006720	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
634177006721	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177006722	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177006723	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177006724	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
634177006725	Diaminopimelate epimerase; Region: DAP_epimerase; cl19724
634177006726	maltose O-acetyltransferase; Provisional; Region: PRK10092
634177006727	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
634177006728	active site
634177006729	substrate binding site [chemical binding]; other site
634177006730	trimer interface [polypeptide binding]; other site
634177006731	CoA binding site [chemical binding]; other site
634177006732	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
634177006733	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634177006734	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634177006735	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
634177006736	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634177006737	HlyD family secretion protein; Region: HlyD_3; pfam13437
634177006738	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
634177006739	MMPL family; Region: MMPL; cl14618
634177006740	MMPL family; Region: MMPL; cl14618
634177006741	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634177006742	Outer membrane efflux protein; Region: OEP; pfam02321
634177006743	Outer membrane efflux protein; Region: OEP; pfam02321
634177006744	hypothetical protein; Provisional; Region: PRK09256
634177006745	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634177006746	active site
634177006747	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
634177006748	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
634177006749	active site
634177006750	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
634177006751	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
634177006752	Substrate binding site; other site
634177006753	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
634177006754	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
634177006755	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634177006756	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
634177006757	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177006758	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
634177006759	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912
634177006760	Lipopolysaccharide-assembly; Region: LptE; pfam04390
634177006761	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
634177006762	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
634177006763	active site
634177006764	HIGH motif; other site
634177006765	KMSKS motif; other site
634177006766	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
634177006767	tRNA binding surface [nucleotide binding]; other site
634177006768	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
634177006769	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
634177006770	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; cl08459
634177006771	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
634177006772	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634177006773	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634177006774	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634177006775	catalytic residue [active]
634177006776	Sporulation related domain; Region: SPOR; pfam05036
634177006777	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
634177006778	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
634177006779	active site
634177006780	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
634177006781	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634177006782	FeS/SAM binding site; other site
634177006783	HemN C-terminal domain; Region: HemN_C; pfam06969
634177006784	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
634177006785	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
634177006786	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
634177006787	catalytic residue [active]
634177006788	NusB family; Region: NusB; pfam01029
634177006789	putative RNA binding site [nucleotide binding]; other site
634177006790	16S rRNA methyltransferase B; Provisional; Region: PRK10901
634177006791	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177006792	S-adenosylmethionine binding site [chemical binding]; other site
634177006793	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
634177006794	substrate binding site [chemical binding]; other site
634177006795	hexamer interface [polypeptide binding]; other site
634177006796	metal binding site [ion binding]; metal-binding site
634177006797	Radical SAM superfamily; Region: Radical_SAM; pfam04055
634177006798	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
634177006799	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
634177006800	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634177006801	putative ADP-binding pocket [chemical binding]; other site
634177006802	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
634177006803	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
634177006804	iron-sulfur cluster [ion binding]; other site
634177006805	[2Fe-2S] cluster binding site [ion binding]; other site
634177006806	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
634177006807	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
634177006808	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
634177006809	active site
634177006810	HIGH motif; other site
634177006811	dimer interface [polypeptide binding]; other site
634177006812	KMSKS motif; other site
634177006813	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634177006814	RNA binding surface [nucleotide binding]; other site
634177006815	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
634177006816	Putative lysophospholipase; Region: Hydrolase_4; cl19140
634177006817	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
634177006818	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
634177006819	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634177006820	catalytic residue [active]
634177006821	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
634177006822	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634177006823	catalytic residue [active]
634177006824	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634177006825	catalytic loop [active]
634177006826	iron binding site [ion binding]; other site
634177006827	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
634177006828	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
634177006829	Ligand Binding Site [chemical binding]; other site
634177006830	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
634177006831	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
634177006832	putative C-terminal domain interface [polypeptide binding]; other site
634177006833	putative GSH binding site (G-site) [chemical binding]; other site
634177006834	putative dimer interface [polypeptide binding]; other site
634177006835	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
634177006836	putative substrate binding pocket (H-site) [chemical binding]; other site
634177006837	putative N-terminal domain interface [polypeptide binding]; other site
634177006838	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634177006839	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634177006840	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
634177006841	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
634177006842	P-loop, Walker A motif; other site
634177006843	Base recognition motif; other site
634177006844	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
634177006845	FOG: WD40 repeat [General function prediction only]; Region: COG2319
634177006846	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
634177006847	structural tetrad; other site
634177006848	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634177006849	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
634177006850	putative ADP-binding pocket [chemical binding]; other site
634177006851	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
634177006852	putative ion selectivity filter; other site
634177006853	putative pore gating glutamate residue; other site
634177006854	putative H+/Cl- coupling transport residue; other site
634177006855	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
634177006856	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
634177006857	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177006858	primosome assembly protein PriA; Validated; Region: PRK05580
634177006859	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634177006860	ATP binding site [chemical binding]; other site
634177006861	putative Mg++ binding site [ion binding]; other site
634177006862	helicase superfamily c-terminal domain; Region: HELICc; smart00490
634177006863	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
634177006864	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634177006865	active site
634177006866	DNA binding site [nucleotide binding]
634177006867	Int/Topo IB signature motif; other site
634177006868	Putative lysophospholipase; Region: Hydrolase_4; cl19140
634177006869	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
634177006870	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
634177006871	catalytic motif [active]
634177006872	Catalytic residue [active]
634177006873	Aspartyl protease; Region: Asp_protease_2; pfam13650
634177006874	inhibitor binding site; inhibition site
634177006875	catalytic motif [active]
634177006876	Catalytic residue [active]
634177006877	Active site flap [active]
634177006878	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
634177006879	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177006880	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
634177006881	serine acetyltransferase; Provisional; Region: cysE; PRK11132
634177006882	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
634177006883	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
634177006884	trimer interface [polypeptide binding]; other site
634177006885	active site
634177006886	substrate binding site [chemical binding]; other site
634177006887	CoA binding site [chemical binding]; other site
634177006888	HI0933-like protein; Region: HI0933_like; pfam03486
634177006889	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634177006890	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177006891	Domain of unknown function DUF87; Region: DUF87; cl19135
634177006892	HerA helicase [Replication, recombination, and repair]; Region: COG0433
634177006893	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
634177006894	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
634177006895	homodimer interface [polypeptide binding]; other site
634177006896	oligonucleotide binding site [chemical binding]; other site
634177006897	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
634177006898	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
634177006899	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
634177006900	active site
634177006901	metal binding site [ion binding]; metal-binding site
634177006902	2-isopropylmalate synthase; Validated; Region: PRK00915
634177006903	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
634177006904	active site
634177006905	catalytic residues [active]
634177006906	metal binding site [ion binding]; metal-binding site
634177006907	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
634177006908	rod shape-determining protein MreB; Provisional; Region: PRK13927
634177006909	MreB and similar proteins; Region: MreB_like; cd10225
634177006910	nucleotide binding site [chemical binding]; other site
634177006911	Mg binding site [ion binding]; other site
634177006912	putative protofilament interaction site [polypeptide binding]; other site
634177006913	RodZ interaction site [polypeptide binding]; other site
634177006914	rod shape-determining protein MreC; Provisional; Region: PRK13922
634177006915	rod shape-determining protein MreD; Region: MreD; cl01087
634177006916	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
634177006917	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
634177006918	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
634177006919	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
634177006920	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
634177006921	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
634177006922	Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092
634177006923	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
634177006924	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
634177006925	dimer interface [polypeptide binding]; other site
634177006926	motif 1; other site
634177006927	active site
634177006928	motif 2; other site
634177006929	motif 3; other site
634177006930	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
634177006931	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3416
634177006932	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; cl17321
634177006933	Entner-Doudoroff aldolase; Region: eda; TIGR01182
634177006934	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
634177006935	active site
634177006936	intersubunit interface [polypeptide binding]; other site
634177006937	catalytic residue [active]
634177006938	phosphogluconate dehydratase; Validated; Region: PRK09054
634177006939	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
634177006940	active site
634177006941	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
634177006942	active site
634177006943	(T/H)XGH motif; other site
634177006944	DNA gyrase subunit A; Validated; Region: PRK05560
634177006945	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
634177006946	CAP-like domain; other site
634177006947	active site
634177006948	primary dimer interface [polypeptide binding]; other site
634177006949	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
634177006950	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
634177006951	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
634177006952	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
634177006953	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
634177006954	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
634177006955	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
634177006956	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
634177006957	dimer interface [polypeptide binding]; other site
634177006958	ssDNA binding site [nucleotide binding]; other site
634177006959	tetramer (dimer of dimers) interface [polypeptide binding]; other site
634177006960	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
634177006961	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
634177006962	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
634177006963	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
634177006964	S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330
634177006965	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177006966	S-adenosylmethionine binding site [chemical binding]; other site
634177006967	Uncharacterized conserved protein [Function unknown]; Region: COG1359
634177006968	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
634177006969	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
634177006970	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
634177006971	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
634177006972	lipoyl attachment site [posttranslational modification]; other site
634177006973	glycine dehydrogenase; Provisional; Region: PRK05367
634177006974	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
634177006975	tetramer interface [polypeptide binding]; other site
634177006976	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177006977	catalytic residue [active]
634177006978	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
634177006979	tetramer interface [polypeptide binding]; other site
634177006980	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177006981	catalytic residue [active]
634177006982	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
634177006983	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
634177006984	intersubunit interface [polypeptide binding]; other site
634177006985	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
634177006986	ABC-ATPase subunit  interface; other site
634177006987	dimer interface [polypeptide binding]; other site
634177006988	putative PBP binding regions; other site
634177006989	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
634177006990	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
634177006991	Walker A/P-loop; other site
634177006992	ATP binding site [chemical binding]; other site
634177006993	Q-loop/lid; other site
634177006994	ABC transporter signature motif; other site
634177006995	Walker B; other site
634177006996	D-loop; other site
634177006997	H-loop/switch region; other site
634177006998	Double-stranded DNA-binding domain; Region: dsDNA_bind; cl00928
634177006999	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177007000	S-adenosylmethionine binding site [chemical binding]; other site
634177007001	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
634177007002	dimer interface [polypeptide binding]; other site
634177007003	active site
634177007004	metal binding site [ion binding]; metal-binding site
634177007005	glutathione binding site [chemical binding]; other site
634177007006	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
634177007007	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
634177007008	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
634177007009	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
634177007010	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
634177007011	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634177007012	FeS/SAM binding site; other site
634177007013	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
634177007014	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
634177007015	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
634177007016	P loop; other site
634177007017	GTP binding site [chemical binding]; other site
634177007018	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
634177007019	substrate binding site [chemical binding]; other site
634177007020	hinge regions; other site
634177007021	ADP binding site [chemical binding]; other site
634177007022	catalytic site [active]
634177007023	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
634177007024	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
634177007025	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
634177007026	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
634177007027	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
634177007028	TPP-binding site [chemical binding]; other site
634177007029	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
634177007030	PYR/PP interface [polypeptide binding]; other site
634177007031	dimer interface [polypeptide binding]; other site
634177007032	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634177007033	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
634177007034	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
634177007035	substrate-cofactor binding pocket; other site
634177007036	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177007037	catalytic residue [active]
634177007038	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
634177007039	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
634177007040	catalytic residues [active]
634177007041	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223
634177007042	recombinase A; Provisional; Region: recA; PRK09354
634177007043	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
634177007044	hexamer interface [polypeptide binding]; other site
634177007045	Walker A motif; other site
634177007046	ATP binding site [chemical binding]; other site
634177007047	Walker B motif; other site
634177007048	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
634177007049	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
634177007050	MOFRL family; Region: MOFRL; pfam05161
634177007051	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
634177007052	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
634177007053	ATP-binding site [chemical binding]; other site
634177007054	CoA-binding site [chemical binding]; other site
634177007055	Mg2+-binding site [ion binding]; other site
634177007056	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
634177007057	NAD binding site [chemical binding]; other site
634177007058	catalytic residues [active]
634177007059	substrate binding site [chemical binding]; other site
634177007060	Ferritin-like domain; Region: Ferritin; pfam00210
634177007061	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
634177007062	dinuclear metal binding motif [ion binding]; other site
634177007063	Transcriptional regulators [Transcription]; Region: GntR; COG1802
634177007064	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
634177007065	DNA-binding site [nucleotide binding]; DNA binding site
634177007066	FCD domain; Region: FCD; pfam07729
634177007067	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
634177007068	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
634177007069	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
634177007070	P-loop; other site
634177007071	ADP binding residues [chemical binding]; other site
634177007072	Switch I; other site
634177007073	Switch II; other site
634177007074	septum formation inhibitor; Reviewed; Region: minC; PRK05177
634177007075	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
634177007076	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
634177007077	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
634177007078	C-terminal domain interface [polypeptide binding]; other site
634177007079	GSH binding site (G-site) [chemical binding]; other site
634177007080	dimer interface [polypeptide binding]; other site
634177007081	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
634177007082	N-terminal domain interface [polypeptide binding]; other site
634177007083	dimer interface [polypeptide binding]; other site
634177007084	substrate binding pocket (H-site) [chemical binding]; other site
634177007085	HI0933-like protein; Region: HI0933_like; pfam03486
634177007086	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177007087	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
634177007088	recombination factor protein RarA; Reviewed; Region: PRK13342
634177007089	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177007090	Walker A motif; other site
634177007091	ATP binding site [chemical binding]; other site
634177007092	Walker B motif; other site
634177007093	arginine finger; other site
634177007094	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
634177007095	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
634177007096	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634177007097	RNA binding surface [nucleotide binding]; other site
634177007098	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
634177007099	active site
634177007100	AsmA family; Region: AsmA; pfam05170
634177007101	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
634177007102	ATP12 chaperone protein; Region: ATP12; cl02228
634177007103	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
634177007104	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
634177007105	substrate binding site; other site
634177007106	dimer interface; other site
634177007107	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
634177007108	homotrimer interaction site [polypeptide binding]; other site
634177007109	zinc binding site [ion binding]; other site
634177007110	CDP-binding sites; other site
634177007111	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
634177007112	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
634177007113	FMN binding site [chemical binding]; other site
634177007114	active site
634177007115	catalytic residues [active]
634177007116	substrate binding site [chemical binding]; other site
634177007117	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
634177007118	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
634177007119	putative active site [active]
634177007120	heme pocket [chemical binding]; other site
634177007121	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634177007122	dimer interface [polypeptide binding]; other site
634177007123	phosphorylation site [posttranslational modification]
634177007124	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177007125	ATP binding site [chemical binding]; other site
634177007126	Mg2+ binding site [ion binding]; other site
634177007127	G-X-G motif; other site
634177007128	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
634177007129	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177007130	active site
634177007131	phosphorylation site [posttranslational modification]
634177007132	intermolecular recognition site; other site
634177007133	dimerization interface [polypeptide binding]; other site
634177007134	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177007135	Walker A motif; other site
634177007136	ATP binding site [chemical binding]; other site
634177007137	Walker B motif; other site
634177007138	arginine finger; other site
634177007139	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
634177007140	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
634177007141	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
634177007142	dimerization interface [polypeptide binding]; other site
634177007143	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634177007144	dimer interface [polypeptide binding]; other site
634177007145	phosphorylation site [posttranslational modification]
634177007146	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177007147	ATP binding site [chemical binding]; other site
634177007148	Mg2+ binding site [ion binding]; other site
634177007149	G-X-G motif; other site
634177007150	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
634177007151	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177007152	active site
634177007153	phosphorylation site [posttranslational modification]
634177007154	intermolecular recognition site; other site
634177007155	dimerization interface [polypeptide binding]; other site
634177007156	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177007157	Walker A motif; other site
634177007158	ATP binding site [chemical binding]; other site
634177007159	Walker B motif; other site
634177007160	arginine finger; other site
634177007161	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
634177007162	bacterial Hfq-like; Region: Hfq; cd01716
634177007163	hexamer interface [polypeptide binding]; other site
634177007164	Sm1 motif; other site
634177007165	RNA binding site [nucleotide binding]; other site
634177007166	Sm2 motif; other site
634177007167	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
634177007168	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
634177007169	HflX GTPase family; Region: HflX; cd01878
634177007170	G1 box; other site
634177007171	GTP/Mg2+ binding site [chemical binding]; other site
634177007172	Switch I region; other site
634177007173	G2 box; other site
634177007174	G3 box; other site
634177007175	Switch II region; other site
634177007176	G4 box; other site
634177007177	G5 box; other site
634177007178	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
634177007179	active site
634177007180	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
634177007181	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
634177007182	homodimer interface [polypeptide binding]; other site
634177007183	metal binding site [ion binding]; metal-binding site
634177007184	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
634177007185	homodimer interface [polypeptide binding]; other site
634177007186	active site
634177007187	putative chemical substrate binding site [chemical binding]; other site
634177007188	metal binding site [ion binding]; metal-binding site
634177007189	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
634177007190	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
634177007191	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
634177007192	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634177007193	catalytic residue [active]
634177007194	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
634177007195	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
634177007196	motif 1; other site
634177007197	dimer interface [polypeptide binding]; other site
634177007198	active site
634177007199	motif 2; other site
634177007200	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
634177007201	GDP-binding site [chemical binding]; other site
634177007202	ACT binding site; other site
634177007203	IMP binding site; other site
634177007204	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
634177007205	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
634177007206	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
634177007207	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634177007208	DNA binding residues [nucleotide binding]
634177007209	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
634177007210	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634177007211	RNA binding surface [nucleotide binding]; other site
634177007212	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
634177007213	active site
634177007214	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
634177007215	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
634177007216	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
634177007217	DXD motif; other site
634177007218	PilZ domain; Region: PilZ; pfam07238
634177007219	potential frameshift: common BLAST hit: gi|339322686|ref|YP_004681580.1| cellulose synthase subunit B
634177007220	Bacterial cellulose synthase subunit; Region: BcsB; pfam03170
634177007221	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
634177007222	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
634177007223	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634177007224	binding surface
634177007225	TPR motif; other site
634177007226	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634177007227	TPR motif; other site
634177007228	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634177007229	binding surface
634177007230	TPR motif; other site
634177007231	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
634177007232	Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500
634177007233	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
634177007234	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
634177007235	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
634177007236	Cupin superfamily (DUF985); Region: Cupin_5; cl01418
634177007237	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
634177007238	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
634177007239	nudix motif; other site
634177007240	heat shock protein 90; Provisional; Region: PRK05218
634177007241	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177007242	ATP binding site [chemical binding]; other site
634177007243	Mg2+ binding site [ion binding]; other site
634177007244	G-X-G motif; other site
634177007245	Hsp90 protein; Region: HSP90; pfam00183
634177007246	potential frameshift: common BLAST hit: gi|53719350|ref|YP_108336.1| putative methyltransferase
634177007247	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
634177007248	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177007249	S-adenosylmethionine binding site [chemical binding]; other site
634177007250	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
634177007251	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
634177007252	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
634177007253	dimer interface [polypeptide binding]; other site
634177007254	anticodon binding site; other site
634177007255	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
634177007256	homodimer interface [polypeptide binding]; other site
634177007257	motif 1; other site
634177007258	active site
634177007259	motif 2; other site
634177007260	motif 3; other site
634177007261	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
634177007262	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
634177007263	putative catalytic site [active]
634177007264	putative phosphate binding site [ion binding]; other site
634177007265	active site
634177007266	metal binding site A [ion binding]; metal-binding site
634177007267	DNA binding site [nucleotide binding]
634177007268	putative AP binding site [nucleotide binding]; other site
634177007269	putative metal binding site B [ion binding]; other site
634177007270	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
634177007271	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
634177007272	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
634177007273	Zn2+ binding site [ion binding]; other site
634177007274	Mg2+ binding site [ion binding]; other site
634177007275	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
634177007276	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
634177007277	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
634177007278	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
634177007279	active site
634177007280	HIGH motif; other site
634177007281	KMSK motif region; other site
634177007282	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
634177007283	tRNA binding surface [nucleotide binding]; other site
634177007284	anticodon binding site; other site
634177007285	Sporulation related domain; Region: SPOR; pfam05036
634177007286	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
634177007287	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
634177007288	sec-independent translocase; Provisional; Region: tatB; PRK00404
634177007289	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
634177007290	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
634177007291	seryl-tRNA synthetase; Provisional; Region: PRK05431
634177007292	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
634177007293	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
634177007294	dimer interface [polypeptide binding]; other site
634177007295	active site
634177007296	motif 1; other site
634177007297	motif 2; other site
634177007298	motif 3; other site
634177007299	P-loop containing region of AAA domain; Region: AAA_29; cl17516
634177007300	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634177007301	nucleotide binding region [chemical binding]; other site
634177007302	ATP-binding site [chemical binding]; other site
634177007303	Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513
634177007304	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
634177007305	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
634177007306	FAD binding pocket [chemical binding]; other site
634177007307	FAD binding motif [chemical binding]; other site
634177007308	phosphate binding motif [ion binding]; other site
634177007309	beta-alpha-beta structure motif; other site
634177007310	NAD binding pocket [chemical binding]; other site
634177007311	glutathione reductase; Validated; Region: PRK06116
634177007312	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177007313	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634177007314	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
634177007315	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
634177007316	nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662
634177007317	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
634177007318	active site
634177007319	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
634177007320	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634177007321	active site
634177007322	nucleotide binding site [chemical binding]; other site
634177007323	HIGH motif; other site
634177007324	KMSKS motif; other site
634177007325	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
634177007326	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
634177007327	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
634177007328	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
634177007329	active site
634177007330	HIGH motif; other site
634177007331	KMSKS motif; other site
634177007332	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
634177007333	tRNA binding surface [nucleotide binding]; other site
634177007334	anticodon binding site; other site
634177007335	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
634177007336	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
634177007337	G1 box; other site
634177007338	putative GEF interaction site [polypeptide binding]; other site
634177007339	GTP/Mg2+ binding site [chemical binding]; other site
634177007340	Switch I region; other site
634177007341	G2 box; other site
634177007342	G3 box; other site
634177007343	Switch II region; other site
634177007344	G4 box; other site
634177007345	G5 box; other site
634177007346	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
634177007347	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
634177007348	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
634177007349	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634177007350	RNA binding surface [nucleotide binding]; other site
634177007351	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
634177007352	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
634177007353	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
634177007354	Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372
634177007355	putative catalytic site [active]
634177007356	putative metal binding site [ion binding]; other site
634177007357	putative catalytic site [active]
634177007358	putative phosphate binding site [ion binding]; other site
634177007359	putative phosphate binding site [ion binding]; other site
634177007360	putative metal binding site [ion binding]; other site
634177007361	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
634177007362	active site clefts [active]
634177007363	zinc binding site [ion binding]; other site
634177007364	dimer interface [polypeptide binding]; other site
634177007365	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
634177007366	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
634177007367	motif 1; other site
634177007368	active site
634177007369	motif 2; other site
634177007370	motif 3; other site
634177007371	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
634177007372	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
634177007373	DHHA1 domain; Region: DHHA1; pfam02272
634177007374	Putative transcription activator [Transcription]; Region: TenA; COG0819
634177007375	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
634177007376	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
634177007377	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
634177007378	ligand binding site [chemical binding]; other site
634177007379	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
634177007380	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
634177007381	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
634177007382	ligand binding site [chemical binding]; other site
634177007383	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
634177007384	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
634177007385	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
634177007386	ligand binding site [chemical binding]; other site
634177007387	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
634177007388	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021
634177007389	ADP binding site [chemical binding]; other site
634177007390	magnesium binding site [ion binding]; other site
634177007391	putative shikimate binding site; other site
634177007392	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
634177007393	active site
634177007394	dimer interface [polypeptide binding]; other site
634177007395	metal binding site [ion binding]; metal-binding site
634177007396	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
634177007397	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634177007398	active site
634177007399	DNA binding site [nucleotide binding]
634177007400	Int/Topo IB signature motif; other site
634177007401	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
634177007402	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
634177007403	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
634177007404	putative MPT binding site; other site
634177007405	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
634177007406	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634177007407	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
634177007408	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
634177007409	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
634177007410	active site
634177007411	8-oxo-dGMP binding site [chemical binding]; other site
634177007412	nudix motif; other site
634177007413	metal binding site [ion binding]; metal-binding site
634177007414	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
634177007415	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
634177007416	[2Fe-2S] cluster binding site [ion binding]; other site
634177007417	Protein of unknown function (DUF815); Region: DUF815; pfam05673
634177007418	Walker A motif; other site
634177007419	ATP binding site [chemical binding]; other site
634177007420	Walker B motif; other site
634177007421	Preprotein translocase subunit; Region: YajC; pfam02699
634177007422	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
634177007423	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177007424	putative substrate translocation pore; other site
634177007425	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
634177007426	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
634177007427	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
634177007428	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
634177007429	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
634177007430	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
634177007431	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
634177007432	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
634177007433	malate:quinone oxidoreductase; Validated; Region: PRK05257
634177007434	Predicted dehydrogenase [General function prediction only]; Region: COG0579
634177007435	Uncharacterized conserved protein [Function unknown]; Region: COG1432
634177007436	LabA_like proteins; Region: LabA; cd10911
634177007437	putative metal binding site [ion binding]; other site
634177007438	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
634177007439	catalytic center binding site [active]
634177007440	ATP binding site [chemical binding]; other site
634177007441	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
634177007442	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
634177007443	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
634177007444	Zn2+ binding site [ion binding]; other site
634177007445	Mg2+ binding site [ion binding]; other site
634177007446	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
634177007447	synthetase active site [active]
634177007448	NTP binding site [chemical binding]; other site
634177007449	metal binding site [ion binding]; metal-binding site
634177007450	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
634177007451	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
634177007452	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
634177007453	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
634177007454	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
634177007455	Catalytic site [active]
634177007456	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
634177007457	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
634177007458	dimerization interface [polypeptide binding]; other site
634177007459	active site
634177007460	metal binding site [ion binding]; metal-binding site
634177007461	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
634177007462	dsRNA binding site [nucleotide binding]; other site
634177007463	GTPase Era; Reviewed; Region: era; PRK00089
634177007464	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
634177007465	G1 box; other site
634177007466	GTP/Mg2+ binding site [chemical binding]; other site
634177007467	Switch I region; other site
634177007468	G2 box; other site
634177007469	Switch II region; other site
634177007470	G3 box; other site
634177007471	G4 box; other site
634177007472	G5 box; other site
634177007473	KH domain; Region: KH_2; pfam07650
634177007474	G-X-X-G motif; other site
634177007475	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
634177007476	putative nucleotide binding site [chemical binding]; other site
634177007477	uridine monophosphate binding site [chemical binding]; other site
634177007478	homohexameric interface [polypeptide binding]; other site
634177007479	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
634177007480	hinge region; other site
634177007481	Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475
634177007482	active site
634177007483	dimer interface [polypeptide binding]; other site
634177007484	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
634177007485	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
634177007486	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
634177007487	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
634177007488	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
634177007489	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
634177007490	RIP metalloprotease RseP; Region: TIGR00054
634177007491	active site
634177007492	putative substrate binding region [chemical binding]; other site
634177007493	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
634177007494	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634177007495	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634177007496	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634177007497	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634177007498	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634177007499	Surface antigen; Region: Bac_surface_Ag; pfam01103
634177007500	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
634177007501	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
634177007502	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
634177007503	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
634177007504	trimer interface [polypeptide binding]; other site
634177007505	active site
634177007506	UDP-GlcNAc binding site [chemical binding]; other site
634177007507	lipid binding site [chemical binding]; lipid-binding site
634177007508	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
634177007509	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
634177007510	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
634177007511	active site
634177007512	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
634177007513	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
634177007514	dimer interface [polypeptide binding]; other site
634177007515	active site
634177007516	metal binding site [ion binding]; metal-binding site
634177007517	glutathione binding site [chemical binding]; other site
634177007518	Ribonuclease P; Region: Ribonuclease_P; pfam00825
634177007519	Haemolytic domain; Region: Haemolytic; pfam01809
634177007520	membrane protein insertase; Provisional; Region: PRK01318
634177007521	YidC periplasmic domain; Region: YidC_periplas; pfam14849
634177007522	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
634177007523	Predicted GTPase [General function prediction only]; Region: COG0218
634177007524	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
634177007525	G1 box; other site
634177007526	GTP/Mg2+ binding site [chemical binding]; other site
634177007527	Switch I region; other site
634177007528	G2 box; other site
634177007529	G3 box; other site
634177007530	Switch II region; other site
634177007531	G4 box; other site
634177007532	G5 box; other site
634177007533	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
634177007534	feedback inhibition sensing region; other site
634177007535	homohexameric interface [polypeptide binding]; other site
634177007536	nucleotide binding site [chemical binding]; other site
634177007537	N-acetyl-L-glutamate binding site [chemical binding]; other site
634177007538	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
634177007539	Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805
634177007540	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
634177007541	trimer interface [polypeptide binding]; other site
634177007542	active site
634177007543	substrate binding site [chemical binding]; other site
634177007544	CoA binding site [chemical binding]; other site
634177007545	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
634177007546	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
634177007547	metal binding site [ion binding]; metal-binding site
634177007548	dimer interface [polypeptide binding]; other site
634177007549	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
634177007550	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
634177007551	dimerization interface 3.5A [polypeptide binding]; other site
634177007552	active site
634177007553	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
634177007554	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
634177007555	putative active site [active]
634177007556	substrate binding site [chemical binding]; other site
634177007557	putative cosubstrate binding site; other site
634177007558	catalytic site [active]
634177007559	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
634177007560	substrate binding site [chemical binding]; other site
634177007561	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
634177007562	active site
634177007563	catalytic residues [active]
634177007564	metal binding site [ion binding]; metal-binding site
634177007565	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
634177007566	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
634177007567	putative dimer interface [polypeptide binding]; other site
634177007568	Protein of unknown function (DUF1150); Region: DUF1150; pfam06620
634177007569	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
634177007570	30S subunit binding site; other site
634177007571	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
634177007572	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
634177007573	Walker A/P-loop; other site
634177007574	ATP binding site [chemical binding]; other site
634177007575	Q-loop/lid; other site
634177007576	ABC transporter signature motif; other site
634177007577	Walker B; other site
634177007578	D-loop; other site
634177007579	H-loop/switch region; other site
634177007580	OstA-like protein; Region: OstA; cl00844
634177007581	OstA-like protein; Region: OstA; cl00844
634177007582	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
634177007583	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
634177007584	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
634177007585	putative active site [active]
634177007586	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
634177007587	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
634177007588	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
634177007589	catalytic site [active]
634177007590	putative active site [active]
634177007591	putative substrate binding site [chemical binding]; other site
634177007592	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
634177007593	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
634177007594	putative NAD(P) binding site [chemical binding]; other site
634177007595	active site
634177007596	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
634177007597	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
634177007598	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634177007599	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
634177007600	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
634177007601	active site
634177007602	dimer interface [polypeptide binding]; other site
634177007603	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
634177007604	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
634177007605	active site
634177007606	FMN binding site [chemical binding]; other site
634177007607	substrate binding site [chemical binding]; other site
634177007608	3Fe-4S cluster binding site [ion binding]; other site
634177007609	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
634177007610	domain interface; other site
634177007611	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
634177007612	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
634177007613	active site
634177007614	Zn binding site [ion binding]; other site
634177007615	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
634177007616	active site
634177007617	ATP binding site [chemical binding]; other site
634177007618	excinuclease ABC subunit B; Provisional; Region: PRK05298
634177007619	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634177007620	ATP binding site [chemical binding]; other site
634177007621	Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
634177007622	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634177007623	nucleotide binding region [chemical binding]; other site
634177007624	ATP-binding site [chemical binding]; other site
634177007625	Ultra-violet resistance protein B; Region: UvrB; pfam12344
634177007626	UvrB/uvrC motif; Region: UVR; pfam02151
634177007627	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
634177007628	active site
634177007629	catalytic residues [active]
634177007630	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
634177007631	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
634177007632	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
634177007633	glutathione synthetase; Provisional; Region: PRK05246
634177007634	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
634177007635	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
634177007636	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177007637	S-adenosylmethionine binding site [chemical binding]; other site
634177007638	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
634177007639	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
634177007640	Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957
634177007641	putative active site [active]
634177007642	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
634177007643	Tim44-like domain; Region: Tim44; pfam04280
634177007644	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
634177007645	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
634177007646	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
634177007647	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
634177007648	threonine synthase; Validated; Region: PRK09225
634177007649	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
634177007650	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177007651	catalytic residue [active]
634177007652	Major royal jelly protein; Region: MRJP; pfam03022
634177007653	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
634177007654	active site
634177007655	Zn binding site [ion binding]; other site
634177007656	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634177007657	binding surface
634177007658	TPR motif; other site
634177007659	Tetratricopeptide repeat; Region: TPR_19; pfam14559
634177007660	TPR repeat; Region: TPR_11; pfam13414
634177007661	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634177007662	binding surface
634177007663	TPR motif; other site
634177007664	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634177007665	PII uridylyl-transferase; Provisional; Region: PRK05092
634177007666	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
634177007667	metal binding triad; other site
634177007668	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
634177007669	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
634177007670	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
634177007671	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
634177007672	MutS domain I; Region: MutS_I; pfam01624
634177007673	MutS domain II; Region: MutS_II; pfam05188
634177007674	MutS domain III; Region: MutS_III; pfam05192
634177007675	MutS domain V; Region: MutS_V; pfam00488
634177007676	Walker A/P-loop; other site
634177007677	ATP binding site [chemical binding]; other site
634177007678	Q-loop/lid; other site
634177007679	ABC transporter signature motif; other site
634177007680	Walker B; other site
634177007681	D-loop; other site
634177007682	H-loop/switch region; other site
634177007683	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
634177007684	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
634177007685	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
634177007686	catalytic residues [active]
634177007687	dimer interface [polypeptide binding]; other site
634177007688	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
634177007689	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
634177007690	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
634177007691	UGMP family protein; Validated; Region: PRK09604
634177007692	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
634177007693	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
634177007694	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
634177007695	domain interfaces; other site
634177007696	active site
634177007697	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
634177007698	active site
634177007699	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
634177007700	SecA binding site; other site
634177007701	Preprotein binding site; other site
634177007702	Tim44-like domain; Region: Tim44; pfam04280
634177007703	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
634177007704	MltA specific insert domain; Region: MltA; smart00925
634177007705	3D domain; Region: 3D; cl01439
634177007706	DNA methylase; Region: N6_N4_Mtase; pfam01555
634177007707	Haem-binding domain; Region: Haem_bd; pfam14376
634177007708	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
634177007709	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
634177007710	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
634177007711	Smr domain; Region: Smr; pfam01713
634177007712	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
634177007713	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
634177007714	Cytochrome c; Region: Cytochrom_C; cl11414
634177007715	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
634177007716	Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005
634177007717	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634177007718	Dienelactone hydrolase family; Region: DLH; pfam01738
634177007719	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
634177007720	oligomerisation interface [polypeptide binding]; other site
634177007721	mobile loop; other site
634177007722	roof hairpin; other site
634177007723	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
634177007724	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
634177007725	ring oligomerisation interface [polypeptide binding]; other site
634177007726	ATP/Mg binding site [chemical binding]; other site
634177007727	stacking interactions; other site
634177007728	hinge regions; other site
634177007729	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177007730	S-adenosylmethionine binding site [chemical binding]; other site
634177007731	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
634177007732	DNA-binding site [nucleotide binding]; DNA binding site
634177007733	RNA-binding motif; other site
634177007734	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
634177007735	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
634177007736	ATP binding site [chemical binding]; other site
634177007737	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
634177007738	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
634177007739	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634177007740	active site
634177007741	nucleotide binding site [chemical binding]; other site
634177007742	HIGH motif; other site
634177007743	KMSKS motif; other site
634177007744	Predicted integral membrane protein [Function unknown]; Region: COG0392
634177007745	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
634177007746	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
634177007747	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
634177007748	ligand binding site [chemical binding]; other site
634177007749	active site
634177007750	NAD-dependent deacetylase; Provisional; Region: PRK00481
634177007751	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634177007752	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634177007753	Cytochrome c; Region: Cytochrom_C; pfam00034
634177007754	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
634177007755	PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279
634177007756	Trp docking motif [polypeptide binding]; other site
634177007757	cytochrome domain interface [polypeptide binding]; other site
634177007758	active site
634177007759	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634177007760	Cytochrome c; Region: Cytochrom_C; pfam00034
634177007761	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
634177007762	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
634177007763	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
634177007764	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
634177007765	The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212
634177007766	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
634177007767	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
634177007768	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
634177007769	D-pathway; other site
634177007770	Putative ubiquinol binding site [chemical binding]; other site
634177007771	Low-spin heme (heme b) binding site [chemical binding]; other site
634177007772	Putative water exit pathway; other site
634177007773	Binuclear center (heme o3/CuB) [ion binding]; other site
634177007774	K-pathway; other site
634177007775	Putative proton exit pathway; other site
634177007776	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
634177007777	Subunit I/III interface [polypeptide binding]; other site
634177007778	Subunit III/IV interface [polypeptide binding]; other site
634177007779	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
634177007780	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
634177007781	4Fe-4S binding domain; Region: Fer4; pfam00037
634177007782	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
634177007783	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634177007784	RNA binding surface [nucleotide binding]; other site
634177007785	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634177007786	ATP binding site [chemical binding]; other site
634177007787	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
634177007788	putative Mg++ binding site [ion binding]; other site
634177007789	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634177007790	nucleotide binding region [chemical binding]; other site
634177007791	ATP-binding site [chemical binding]; other site
634177007792	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
634177007793	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
634177007794	interface (dimer of trimers) [polypeptide binding]; other site
634177007795	Substrate-binding/catalytic site; other site
634177007796	Zn-binding sites [ion binding]; other site
634177007797	Transcriptional regulators [Transcription]; Region: MarR; COG1846
634177007798	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
634177007799	putative DNA binding site [nucleotide binding]; other site
634177007800	putative Zn2+ binding site [ion binding]; other site
634177007801	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
634177007802	Mg++ binding site [ion binding]; other site
634177007803	putative catalytic motif [active]
634177007804	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
634177007805	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
634177007806	NAD(P) binding site [chemical binding]; other site
634177007807	homodimer interface [polypeptide binding]; other site
634177007808	substrate binding site [chemical binding]; other site
634177007809	active site
634177007810	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
634177007811	inhibitor-cofactor binding pocket; inhibition site
634177007812	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177007813	catalytic residue [active]
634177007814	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
634177007815	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634177007816	active site
634177007817	motif I; other site
634177007818	motif II; other site
634177007819	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
634177007820	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
634177007821	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177007822	putative substrate translocation pore; other site
634177007823	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
634177007824	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634177007825	ABC transporter; Region: ABC_tran_2; pfam12848
634177007826	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634177007827	Nucleoside diphosphate kinase; Region: NDK; pfam00334
634177007828	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
634177007829	active site
634177007830	multimer interface [polypeptide binding]; other site
634177007831	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
634177007832	active site
634177007833	substrate binding site [chemical binding]; other site
634177007834	cosubstrate binding site; other site
634177007835	catalytic site [active]
634177007836	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
634177007837	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
634177007838	dimerization interface [polypeptide binding]; other site
634177007839	putative ATP binding site [chemical binding]; other site
634177007840	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
634177007841	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
634177007842	polyphosphate kinase; Provisional; Region: PRK05443
634177007843	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
634177007844	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
634177007845	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
634177007846	putative domain interface [polypeptide binding]; other site
634177007847	putative active site [active]
634177007848	catalytic site [active]
634177007849	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
634177007850	putative domain interface [polypeptide binding]; other site
634177007851	putative active site [active]
634177007852	catalytic site [active]
634177007853	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
634177007854	exopolyphosphatase; Region: exo_poly_only; TIGR03706
634177007855	phenylhydantoinase; Validated; Region: PRK08323
634177007856	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634177007857	active site
634177007858	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
634177007859	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634177007860	catalytic loop [active]
634177007861	iron binding site [ion binding]; other site
634177007862	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
634177007863	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
634177007864	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
634177007865	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
634177007866	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
634177007867	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634177007868	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
634177007869	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
634177007870	XdhC Rossmann domain; Region: XdhC_C; pfam13478
634177007871	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177007872	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177007873	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
634177007874	dimerization interface [polypeptide binding]; other site
634177007875	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
634177007876	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
634177007877	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
634177007878	amidase; Provisional; Region: PRK09201
634177007879	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
634177007880	allantoate amidohydrolase; Reviewed; Region: PRK09290
634177007881	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
634177007882	active site
634177007883	metal binding site [ion binding]; metal-binding site
634177007884	dimer interface [polypeptide binding]; other site
634177007885	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
634177007886	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634177007887	catalytic residue [active]
634177007888	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
634177007889	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
634177007890	active site
634177007891	catalytic site [active]
634177007892	tetramer interface [polypeptide binding]; other site
634177007893	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
634177007894	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
634177007895	active site
634177007896	homotetramer interface [polypeptide binding]; other site
634177007897	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
634177007898	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
634177007899	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
634177007900	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
634177007901	active site
634177007902	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
634177007903	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634177007904	Coenzyme A binding pocket [chemical binding]; other site
634177007905	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
634177007906	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
634177007907	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177007908	S-adenosylmethionine binding site [chemical binding]; other site
634177007909	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
634177007910	Part of AAA domain; Region: AAA_19; pfam13245
634177007911	RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570
634177007912	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
634177007913	DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003
634177007914	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
634177007915	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
634177007916	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634177007917	motif II; other site
634177007918	DNA repair protein radc; Region: radc; TIGR00608
634177007919	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
634177007920	MPN+ (JAMM) motif; other site
634177007921	Zinc-binding site [ion binding]; other site
634177007922	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
634177007923	ATP-grasp domain; Region: ATP-grasp; pfam02222
634177007924	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
634177007925	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
634177007926	Protein of unknown function (DUF465); Region: DUF465; cl01070
634177007927	Protein of unknown function (DUF1013); Region: DUF1013; cl11533
634177007928	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
634177007929	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
634177007930	putative dimer interface [polypeptide binding]; other site
634177007931	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
634177007932	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
634177007933	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
634177007934	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
634177007935	Protein export membrane protein; Region: SecD_SecF; pfam02355
634177007936	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
634177007937	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
634177007938	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
634177007939	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
634177007940	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
634177007941	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
634177007942	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634177007943	ABC transporter ATPase component; Reviewed; Region: PRK11147
634177007944	ABC transporter; Region: ABC_tran_2; pfam12848
634177007945	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634177007946	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
634177007947	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
634177007948	active site
634177007949	homotetramer interface [polypeptide binding]; other site
634177007950	two-component response regulator; Provisional; Region: PRK09191
634177007951	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177007952	active site
634177007953	phosphorylation site [posttranslational modification]
634177007954	intermolecular recognition site; other site
634177007955	dimerization interface [polypeptide binding]; other site
634177007956	RNA polymerase sigma factor; Provisional; Region: PRK12547
634177007957	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
634177007958	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634177007959	DNA binding residues [nucleotide binding]
634177007960	RNA polymerase sigma factor; Provisional; Region: PRK12547
634177007961	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
634177007962	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634177007963	DNA binding residues [nucleotide binding]
634177007964	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
634177007965	Histidine kinase; Region: HisKA_2; pfam07568
634177007966	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177007967	ATP binding site [chemical binding]; other site
634177007968	Mg2+ binding site [ion binding]; other site
634177007969	G-X-G motif; other site
634177007970	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
634177007971	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634177007972	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
634177007973	Walker A/P-loop; other site
634177007974	ATP binding site [chemical binding]; other site
634177007975	Q-loop/lid; other site
634177007976	ABC transporter signature motif; other site
634177007977	Walker B; other site
634177007978	D-loop; other site
634177007979	H-loop/switch region; other site
634177007980	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634177007981	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
634177007982	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177007983	Walker A/P-loop; other site
634177007984	ATP binding site [chemical binding]; other site
634177007985	Q-loop/lid; other site
634177007986	ABC transporter signature motif; other site
634177007987	Walker B; other site
634177007988	D-loop; other site
634177007989	H-loop/switch region; other site
634177007990	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
634177007991	ligand binding site [chemical binding]; other site
634177007992	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
634177007993	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634177007994	ATP binding site [chemical binding]; other site
634177007995	putative Mg++ binding site [ion binding]; other site
634177007996	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634177007997	nucleotide binding region [chemical binding]; other site
634177007998	ATP-binding site [chemical binding]; other site
634177007999	RQC domain; Region: RQC; pfam09382
634177008000	HRDC domain; Region: HRDC; pfam00570
634177008001	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
634177008002	Transcription elongation factor Elf1 like; Region: Elf1; cl02038
634177008003	ATP cone domain; Region: ATP-cone; pfam03477
634177008004	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
634177008005	putative RNA binding site [nucleotide binding]; other site
634177008006	thiamine monophosphate kinase; Provisional; Region: PRK05731
634177008007	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
634177008008	ATP binding site [chemical binding]; other site
634177008009	dimerization interface [polypeptide binding]; other site
634177008010	short chain dehydrogenase; Provisional; Region: PRK06181
634177008011	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177008012	NAD(P) binding site [chemical binding]; other site
634177008013	active site
634177008014	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
634177008015	nucleotide binding site [chemical binding]; other site
634177008016	benzoylformate decarboxylase; Reviewed; Region: PRK07092
634177008017	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
634177008018	PYR/PP interface [polypeptide binding]; other site
634177008019	dimer interface [polypeptide binding]; other site
634177008020	TPP binding site [chemical binding]; other site
634177008021	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634177008022	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
634177008023	TPP-binding site [chemical binding]; other site
634177008024	dimer interface [polypeptide binding]; other site
634177008025	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
634177008026	substrate binding site [chemical binding]; other site
634177008027	multimerization interface [polypeptide binding]; other site
634177008028	ATP binding site [chemical binding]; other site
634177008029	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
634177008030	Transposase domain (DUF772); Region: DUF772; pfam05598
634177008031	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177008032	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177008033	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
634177008034	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563
634177008035	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
634177008036	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
634177008037	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
634177008038	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634177008039	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
634177008040	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
634177008041	DXD motif; other site
634177008042	PilZ domain; Region: PilZ; pfam07238
634177008043	Bacterial cellulose synthase subunit; Region: BcsB; pfam03170
634177008044	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
634177008045	active site
634177008046	catalytic triad [active]
634177008047	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
634177008048	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634177008049	Transposase; Region: HTH_Tnp_1; pfam01527
634177008050	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634177008051	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634177008052	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634177008053	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634177008054	zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005
634177008055	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634177008056	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634177008057	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634177008058	binding surface
634177008059	TPR motif; other site
634177008060	Tetratricopeptide repeat; Region: TPR_19; pfam14559
634177008061	TPR repeat; Region: TPR_11; pfam13414
634177008062	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634177008063	binding surface
634177008064	TPR motif; other site
634177008065	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634177008066	TPR motif; other site
634177008067	binding surface
634177008068	Tetratricopeptide repeat; Region: TPR_19; pfam14559
634177008069	Tetratricopeptide repeat; Region: TPR_19; pfam14559
634177008070	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
634177008071	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
634177008072	active site
634177008073	catalytic triad [active]
634177008074	oxyanion hole [active]
634177008075	TMAO/DMSO reductase; Reviewed; Region: PRK05363
634177008076	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
634177008077	Moco binding site; other site
634177008078	metal coordination site [ion binding]; other site
634177008079	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
634177008080	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
634177008081	Bacterial transcriptional regulator; Region: IclR; pfam01614
634177008082	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
634177008083	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
634177008084	tetramer interface [polypeptide binding]; other site
634177008085	TPP-binding site [chemical binding]; other site
634177008086	heterodimer interface [polypeptide binding]; other site
634177008087	phosphorylation loop region [posttranslational modification]
634177008088	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
634177008089	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
634177008090	alpha subunit interface [polypeptide binding]; other site
634177008091	TPP binding site [chemical binding]; other site
634177008092	heterodimer interface [polypeptide binding]; other site
634177008093	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634177008094	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
634177008095	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634177008096	E3 interaction surface; other site
634177008097	lipoyl attachment site [posttranslational modification]; other site
634177008098	Putative lysophospholipase; Region: Hydrolase_4; cl19140
634177008099	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
634177008100	N- and C-terminal domain interface [polypeptide binding]; other site
634177008101	D-xylulose kinase; Region: XylB; TIGR01312
634177008102	active site
634177008103	MgATP binding site [chemical binding]; other site
634177008104	catalytic site [active]
634177008105	metal binding site [ion binding]; metal-binding site
634177008106	xylulose binding site [chemical binding]; other site
634177008107	homodimer interface [polypeptide binding]; other site
634177008108	Major royal jelly protein; Region: MRJP; pfam03022
634177008109	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
634177008110	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177008111	putative substrate translocation pore; other site
634177008112	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177008113	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
634177008114	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634177008115	catalytic residue [active]
634177008116	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
634177008117	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
634177008118	NADP binding site [chemical binding]; other site
634177008119	active site
634177008120	putative substrate binding site [chemical binding]; other site
634177008121	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
634177008122	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
634177008123	Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107
634177008124	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
634177008125	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
634177008126	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
634177008127	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634177008128	active site
634177008129	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844
634177008130	putative ADP-binding pocket [chemical binding]; other site
634177008131	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634177008132	putative glycosyl transferase; Provisional; Region: PRK10073
634177008133	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
634177008134	active site
634177008135	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
634177008136	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
634177008137	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
634177008138	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
634177008139	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
634177008140	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
634177008141	Substrate binding site; other site
634177008142	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
634177008143	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
634177008144	CoA binding domain; Region: CoA_binding; cl17356
634177008145	Bacterial sugar transferase; Region: Bac_transf; pfam02397
634177008146	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
634177008147	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
634177008148	Chain length determinant protein; Region: Wzz; pfam02706
634177008149	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
634177008150	AAA domain; Region: AAA_31; pfam13614
634177008151	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634177008152	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
634177008153	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
634177008154	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
634177008155	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl19246
634177008156	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
634177008157	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
634177008158	SLBB domain; Region: SLBB; pfam10531
634177008159	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
634177008160	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
634177008161	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
634177008162	NAD binding site [chemical binding]; other site
634177008163	substrate binding site [chemical binding]; other site
634177008164	homodimer interface [polypeptide binding]; other site
634177008165	active site
634177008166	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
634177008167	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
634177008168	substrate binding site; other site
634177008169	tetramer interface; other site
634177008170	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
634177008171	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177008172	NAD(P) binding site [chemical binding]; other site
634177008173	active site
634177008174	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
634177008175	Ferritin-like domain; Region: Ferritin; pfam00210
634177008176	dimerization interface [polypeptide binding]; other site
634177008177	DPS ferroxidase diiron center [ion binding]; other site
634177008178	ion pore; other site
634177008179	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370
634177008180	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
634177008181	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634177008182	major facilitator superfamily transporter; Provisional; Region: PRK05122
634177008183	putative substrate translocation pore; other site
634177008184	Uncharacterized conserved protein [Function unknown]; Region: COG1359
634177008185	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
634177008186	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
634177008187	DNA-binding site [nucleotide binding]; DNA binding site
634177008188	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634177008189	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177008190	homodimer interface [polypeptide binding]; other site
634177008191	catalytic residue [active]
634177008192	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
634177008193	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
634177008194	Na binding site [ion binding]; other site
634177008195	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177008196	S-adenosylmethionine binding site [chemical binding]; other site
634177008197	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
634177008198	Outer membrane efflux protein; Region: OEP; pfam02321
634177008199	Outer membrane efflux protein; Region: OEP; pfam02321
634177008200	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
634177008201	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
634177008202	active site
634177008203	HIGH motif; other site
634177008204	KMSKS motif; other site
634177008205	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
634177008206	tRNA binding surface [nucleotide binding]; other site
634177008207	anticodon binding site; other site
634177008208	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
634177008209	methionine sulfoxide reductase A; Provisional; Region: PRK14054
634177008210	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
634177008211	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
634177008212	Walker A/P-loop; other site
634177008213	ATP binding site [chemical binding]; other site
634177008214	Q-loop/lid; other site
634177008215	ABC transporter signature motif; other site
634177008216	Walker B; other site
634177008217	D-loop; other site
634177008218	H-loop/switch region; other site
634177008219	C-terminal AAA-associated domain; Region: AAA_assoc_C; pfam09821
634177008220	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
634177008221	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634177008222	dimer interface [polypeptide binding]; other site
634177008223	conserved gate region; other site
634177008224	putative PBP binding loops; other site
634177008225	ABC-ATPase subunit interface; other site
634177008226	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634177008227	dimer interface [polypeptide binding]; other site
634177008228	conserved gate region; other site
634177008229	putative PBP binding loops; other site
634177008230	ABC-ATPase subunit interface; other site
634177008231	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
634177008232	trimer interface [polypeptide binding]; other site
634177008233	active site
634177008234	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
634177008235	Flavoprotein; Region: Flavoprotein; cl19190
634177008236	DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127
634177008237	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
634177008238	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177008239	S-adenosylmethionine binding site [chemical binding]; other site
634177008240	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
634177008241	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
634177008242	DNA binding site [nucleotide binding]
634177008243	catalytic residue [active]
634177008244	H2TH interface [polypeptide binding]; other site
634177008245	putative catalytic residues [active]
634177008246	turnover-facilitating residue; other site
634177008247	intercalation triad [nucleotide binding]; other site
634177008248	8OG recognition residue [nucleotide binding]; other site
634177008249	putative reading head residues; other site
634177008250	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
634177008251	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
634177008252	Replication initiator protein A; Region: RPA; pfam10134
634177008253	ParA-like protein; Provisional; Region: PHA02518
634177008254	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634177008255	P-loop; other site
634177008256	Magnesium ion binding site [ion binding]; other site
634177008257	Resolvase, N terminal domain; Region: Resolvase; pfam00239
634177008258	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634177008259	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634177008260	catalytic residues [active]
634177008261	catalytic nucleophile [active]
634177008262	Presynaptic Site I dimer interface [polypeptide binding]; other site
634177008263	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634177008264	Synaptic Flat tetramer interface [polypeptide binding]; other site
634177008265	Synaptic Site I dimer interface [polypeptide binding]; other site
634177008266	DNA binding site [nucleotide binding]
634177008267	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393
634177008268	DNA-binding interface [nucleotide binding]; DNA binding site
634177008269	putative Mg(2+) transport ATPase; Provisional; Region: PRK09977
634177008270	MgtC family; Region: MgtC; pfam02308
634177008271	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
634177008272	DNA binding residues [nucleotide binding]
634177008273	alkylmercury lyase; Provisional; Region: PRK13239
634177008274	Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324
634177008275	Alkylmercury lyase; Region: MerB; pfam03243
634177008276	mercuric reductase; Region: MerA; TIGR02053
634177008277	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177008278	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634177008279	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
634177008280	Membrane transport protein MerF; Region: Transport_MerF; pfam11431
634177008281	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
634177008282	metal-binding site [ion binding]
634177008283	MerT mercuric transport protein; Region: MerT; cl03578
634177008284	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
634177008285	DNA binding residues [nucleotide binding]
634177008286	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
634177008287	dimer interface [polypeptide binding]; other site
634177008288	putative metal binding site [ion binding]; other site
634177008289	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634177008290	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634177008291	catalytic residues [active]
634177008292	catalytic nucleophile [active]
634177008293	Presynaptic Site I dimer interface [polypeptide binding]; other site
634177008294	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634177008295	Synaptic Flat tetramer interface [polypeptide binding]; other site
634177008296	Synaptic Site I dimer interface [polypeptide binding]; other site
634177008297	DNA binding site [nucleotide binding]
634177008298	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393
634177008299	DNA-binding interface [nucleotide binding]; DNA binding site
634177008300	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
634177008301	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
634177008302	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
634177008303	inner capsid protein lambda-1 or VP3; Region: lambda-1; cd11674
634177008304	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634177008305	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634177008306	catalytic residues [active]
634177008307	catalytic nucleophile [active]
634177008308	Presynaptic Site I dimer interface [polypeptide binding]; other site
634177008309	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634177008310	Synaptic Flat tetramer interface [polypeptide binding]; other site
634177008311	Synaptic Site I dimer interface [polypeptide binding]; other site
634177008312	DNA binding site [nucleotide binding]
634177008313	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
634177008314	DNA-binding interface [nucleotide binding]; DNA binding site
634177008315	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
634177008316	Methyltransferase domain; Region: Methyltransf_26; pfam13659
634177008317	transposase/IS protein; Provisional; Region: PRK09183
634177008318	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634177008319	Walker A motif; other site
634177008320	ATP binding site [chemical binding]; other site
634177008321	Walker B motif; other site
634177008322	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
634177008323	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393
634177008324	Integrase core domain; Region: rve; pfam00665
634177008325	Integrase core domain; Region: rve_3; cl15866
634177008326	Fic family protein [Function unknown]; Region: COG3177
634177008327	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
634177008328	Fic/DOC family; Region: Fic; pfam02661
634177008329	Winged helix-turn-helix; Region: HTH_45; cl01362
634177008330	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
634177008331	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
634177008332	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
634177008333	putative active site [active]
634177008334	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
634177008335	conjugal transfer relaxase TraA; Provisional; Region: PRK13889
634177008336	Conjugal transfer protein TraD; Region: TraD; pfam06412
634177008337	Conjugal transfer protein TraD; Region: TraD; pfam06412
634177008338	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
634177008339	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
634177008340	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
634177008341	putative active site [active]
634177008342	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
634177008343	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
634177008344	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
634177008345	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
634177008346	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
634177008347	DNA binding site [nucleotide binding]
634177008348	dimer interface [polypeptide binding]; other site
634177008349	active site
634177008350	Int/Topo IB signature motif; other site
634177008351	Helix-turn-helix domain; Region: HTH_36; pfam13730
634177008352	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634177008353	salt bridge; other site
634177008354	non-specific DNA binding site [nucleotide binding]; other site
634177008355	sequence-specific DNA binding site [nucleotide binding]; other site
634177008356	RelB antitoxin; Region: RelB; cl01171
634177008357	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
634177008358	Pou domain - N-terminal to homeobox domain; Region: Pou; cl02582
634177008359	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
634177008360	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634177008361	P-loop; other site
634177008362	Magnesium ion binding site [ion binding]; other site
634177008363	ParB-like nuclease domain; Region: ParB; smart00470
634177008364	KorB domain; Region: KorB; pfam08535
634177008365	Replication initiator protein A; Region: RPA; pfam10134
634177008366	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
634177008367	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177008368	S-adenosylmethionine binding site [chemical binding]; other site
634177008369	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
634177008370	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634177008371	Uncharacterized protein conserved in archaea (DUF2240); Region: DUF2240; cl01449
634177008372	helicase superfamily c-terminal domain; Region: HELICc; smart00490
634177008373	plasmid partitioning protein; Provisional; Region: PRK13832
634177008374	ParB-like nuclease domain; Region: ParB; smart00470
634177008375	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
634177008376	Ligand Binding Site [chemical binding]; other site
634177008377	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
634177008378	Transposase; Region: DEDD_Tnp_IS110; pfam01548
634177008379	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
634177008380	Protein of unknown function (DUF3085); Region: DUF3085; pfam11284
634177008381	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
634177008382	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
634177008383	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
634177008384	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
634177008385	dimer interface [polypeptide binding]; other site
634177008386	ssDNA binding site [nucleotide binding]; other site
634177008387	tetramer (dimer of dimers) interface [polypeptide binding]; other site
634177008388	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
634177008389	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
634177008390	active site
634177008391	metal binding site [ion binding]; metal-binding site
634177008392	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
634177008393	Part of AAA domain; Region: AAA_19; pfam13245
634177008394	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
634177008395	Nuclease-related domain; Region: NERD; pfam08378
634177008396	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
634177008397	dimerization interface [polypeptide binding]; other site
634177008398	putative DNA binding site [nucleotide binding]; other site
634177008399	Transcriptional regulators [Transcription]; Region: MarR; COG1846
634177008400	putative Zn2+ binding site [ion binding]; other site
634177008401	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
634177008402	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
634177008403	putative NAD(P) binding site [chemical binding]; other site
634177008404	dimer interface [polypeptide binding]; other site
634177008405	Cupin domain; Region: Cupin_2; cl17218
634177008406	BRO family, N-terminal domain; Region: Bro-N; smart01040
634177008407	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
634177008408	Transposase; Region: DEDD_Tnp_IS110; pfam01548
634177008409	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
634177008410	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177008411	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177008412	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634177008413	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
634177008414	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634177008415	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177008416	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634177008417	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177008418	TrwC relaxase; Region: TrwC; cl19905
634177008419	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
634177008420	AAA domain; Region: AAA_30; pfam13604
634177008421	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
634177008422	Fic/DOC family; Region: Fic; pfam02661
634177008423	Fic family protein [Function unknown]; Region: COG3177
634177008424	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl19880
634177008425	Protein of unknown function (DUF1173); Region: DUF1173; pfam06666
634177008426	Domain of unknown function DUF87; Region: DUF87; cl19135
634177008427	AAA-like domain; Region: AAA_10; pfam12846
634177008428	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634177008429	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634177008430	catalytic residue [active]
634177008431	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
634177008432	Walker A motif; other site
634177008433	ATP binding site [chemical binding]; other site
634177008434	Walker B motif; other site
634177008435	PLD-like domain; Region: PLDc_2; pfam13091
634177008436	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177008437	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177008438	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634177008439	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634177008440	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634177008441	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634177008442	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634177008443	zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005
634177008444	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634177008445	aspartate aminotransferase; Provisional; Region: PRK05764
634177008446	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634177008447	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177008448	homodimer interface [polypeptide binding]; other site
634177008449	catalytic residue [active]
634177008450	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634177008451	non-specific DNA binding site [nucleotide binding]; other site
634177008452	salt bridge; other site
634177008453	sequence-specific DNA binding site [nucleotide binding]; other site
634177008454	HipA N-terminal domain; Region: Couple_hipA; cl11853
634177008455	HipA-like N-terminal domain; Region: HipA_N; pfam07805
634177008456	HipA-like C-terminal domain; Region: HipA_C; pfam07804
634177008457	AAA-like domain; Region: AAA_10; pfam12846
634177008458	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634177008459	non-specific DNA binding site [nucleotide binding]; other site
634177008460	salt bridge; other site
634177008461	sequence-specific DNA binding site [nucleotide binding]; other site
634177008462	Protein of unknown function (DUF497); Region: DUF497; pfam04365
634177008463	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323
634177008464	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
634177008465	Protein of unknown function (DUF3625); Region: DUF3625; pfam12293
634177008466	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
634177008467	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634177008468	non-specific DNA binding site [nucleotide binding]; other site
634177008469	salt bridge; other site
634177008470	sequence-specific DNA binding site [nucleotide binding]; other site
634177008471	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634177008472	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634177008473	non-specific DNA binding site [nucleotide binding]; other site
634177008474	salt bridge; other site
634177008475	sequence-specific DNA binding site [nucleotide binding]; other site
634177008476	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
634177008477	Protein of unknown function (DUF1043); Region: DUF1043; cl11473
634177008478	phage lambda Rz1-like protein; Region: PHA02047
634177008479	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177008480	active site
634177008481	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634177008482	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
634177008483	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
634177008484	PemK-like protein; Region: PemK; cl00995
634177008485	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634177008486	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177008487	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
634177008488	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
634177008489	Outer membrane efflux protein; Region: OEP; pfam02321
634177008490	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
634177008491	HlyD family secretion protein; Region: HlyD_3; pfam13437
634177008492	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
634177008493	MMPL family; Region: MMPL; cl14618
634177008494	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634177008495	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177008496	active site
634177008497	phosphorylation site [posttranslational modification]
634177008498	intermolecular recognition site; other site
634177008499	dimerization interface [polypeptide binding]; other site
634177008500	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634177008501	DNA binding site [nucleotide binding]
634177008502	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634177008503	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
634177008504	dimerization interface [polypeptide binding]; other site
634177008505	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634177008506	dimer interface [polypeptide binding]; other site
634177008507	phosphorylation site [posttranslational modification]
634177008508	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177008509	ATP binding site [chemical binding]; other site
634177008510	Mg2+ binding site [ion binding]; other site
634177008511	G-X-G motif; other site
634177008512	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634177008513	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634177008514	zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005
634177008515	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634177008516	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634177008517	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634177008518	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634177008519	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634177008520	Transposase; Region: HTH_Tnp_1; pfam01527
634177008521	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177008522	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177008523	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
634177008524	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
634177008525	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
634177008526	dimerization interface [polypeptide binding]; other site
634177008527	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634177008528	dimer interface [polypeptide binding]; other site
634177008529	phosphorylation site [posttranslational modification]
634177008530	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634177008531	ATP binding site [chemical binding]; other site
634177008532	Mg2+ binding site [ion binding]; other site
634177008533	G-X-G motif; other site
634177008534	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634177008535	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634177008536	active site
634177008537	phosphorylation site [posttranslational modification]
634177008538	intermolecular recognition site; other site
634177008539	dimerization interface [polypeptide binding]; other site
634177008540	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634177008541	DNA binding site [nucleotide binding]
634177008542	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
634177008543	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
634177008544	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634177008545	potential frameshift: common BLAST hit: gi|260753362|ref|YP_003226255.1| carbohydrate-selective porin OprB
634177008546	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
634177008547	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634177008548	B12 binding domain; Region: B12-binding; pfam02310
634177008549	B12 binding site [chemical binding]; other site
634177008550	Radical SAM superfamily; Region: Radical_SAM; pfam04055
634177008551	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634177008552	FeS/SAM binding site; other site
634177008553	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
634177008554	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
634177008555	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
634177008556	transmembrane helices; other site
634177008557	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
634177008558	catalytic residues [active]
634177008559	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
634177008560	dimerization interface [polypeptide binding]; other site
634177008561	putative DNA binding site [nucleotide binding]; other site
634177008562	putative Zn2+ binding site [ion binding]; other site
634177008563	potential frameshift: common BLAST hit: gi|116620864|ref|YP_823020.1| multicopper oxidase, type 2
634177008564	Cupredoxin superfamily; Region: Cupredoxin; cl19115
634177008565	Cupredoxin superfamily; Region: Cupredoxin; cl19115
634177008566	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
634177008567	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634177008568	Walker A/P-loop; other site
634177008569	ATP binding site [chemical binding]; other site
634177008570	ABC transporter signature motif; other site
634177008571	Walker B; other site
634177008572	D-loop; other site
634177008573	H-loop/switch region; other site
634177008574	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
634177008575	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634177008576	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
634177008577	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634177008578	S-adenosylmethionine binding site [chemical binding]; other site
634177008579	Iron-containing redox enzyme; Region: Haem_oxygenas_2; pfam14518
634177008580	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
634177008581	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
634177008582	HTH-like domain; Region: HTH_21; pfam13276
634177008583	Integrase core domain; Region: rve; pfam00665
634177008584	Transposase; Region: HTH_Tnp_1; pfam01527
634177008585	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
634177008586	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
634177008587	THF binding site; other site
634177008588	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
634177008589	substrate binding site [chemical binding]; other site
634177008590	THF binding site; other site
634177008591	zinc-binding site [ion binding]; other site
634177008592	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177008593	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177008594	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
634177008595	putative dimerization interface [polypeptide binding]; other site
634177008596	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
634177008597	short chain dehydrogenase; Provisional; Region: PRK07074
634177008598	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
634177008599	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
634177008600	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
634177008601	[2Fe-2S] cluster binding site [ion binding]; other site
634177008602	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
634177008603	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
634177008604	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
634177008605	Walker A/P-loop; other site
634177008606	ATP binding site [chemical binding]; other site
634177008607	Q-loop/lid; other site
634177008608	ABC transporter signature motif; other site
634177008609	Walker B; other site
634177008610	D-loop; other site
634177008611	H-loop/switch region; other site
634177008612	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
634177008613	ABC-ATPase subunit  interface; other site
634177008614	dimer interface [polypeptide binding]; other site
634177008615	putative PBP binding regions; other site
634177008616	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
634177008617	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
634177008618	intersubunit interface [polypeptide binding]; other site
634177008619	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
634177008620	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634177008621	N-terminal plug; other site
634177008622	ligand-binding site [chemical binding]; other site
634177008623	cobyric acid synthase; Provisional; Region: PRK00784
634177008624	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
634177008625	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
634177008626	catalytic triad [active]
634177008627	Transposase; Region: HTH_Tnp_1; cl17663
634177008628	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634177008629	putative transposase OrfB; Reviewed; Region: PHA02517
634177008630	HTH-like domain; Region: HTH_21; pfam13276
634177008631	Integrase core domain; Region: rve; pfam00665
634177008632	Integrase core domain; Region: rve_3; pfam13683
634177008633	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
634177008634	[2Fe-2S] cluster binding site [ion binding]; other site
634177008635	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
634177008636	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634177008637	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
634177008638	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
634177008639	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
634177008640	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
634177008641	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
634177008642	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; cl19160
634177008643	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
634177008644	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
634177008645	generic binding surface I; other site
634177008646	generic binding surface II; other site
634177008647	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
634177008648	putative active site [active]
634177008649	putative PHP Thumb interface [polypeptide binding]; other site
634177008650	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
634177008651	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
634177008652	Transposase; Region: DEDD_Tnp_IS110; pfam01548
634177008653	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
634177008654	DNA Polymerase Y-family; Region: PolY_like; cd03468
634177008655	active site
634177008656	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
634177008657	DNA binding site [nucleotide binding]
634177008658	Uncharacterized conserved protein [Function unknown]; Region: COG4544
634177008659	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
634177008660	Predicted helicase [General function prediction only]; Region: COG4889
634177008661	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
634177008662	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634177008663	ATP binding site [chemical binding]; other site
634177008664	putative Mg++ binding site [ion binding]; other site
634177008665	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
634177008666	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177008667	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177008668	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634177008669	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
634177008670	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177008671	RES domain; Region: RES; pfam08808
634177008672	ScpA/B protein; Region: ScpA_ScpB; cl00598
634177008673	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
634177008674	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
634177008675	DNA binding site [nucleotide binding]
634177008676	dimer interface [polypeptide binding]; other site
634177008677	active site
634177008678	Int/Topo IB signature motif; other site
634177008679	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
634177008680	DNA binding residues [nucleotide binding]
634177008681	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
634177008682	dimer interface [polypeptide binding]; other site
634177008683	putative metal binding site [ion binding]; other site
634177008684	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
634177008685	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
634177008686	Outer membrane efflux protein; Region: OEP; pfam02321
634177008687	Outer membrane efflux protein; Region: OEP; pfam02321
634177008688	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
634177008689	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
634177008690	HTH-like domain; Region: HTH_21; pfam13276
634177008691	Integrase core domain; Region: rve; pfam00665
634177008692	Integrase core domain; Region: rve_3; pfam13683
634177008693	Transposase; Region: HTH_Tnp_1; cl17663
634177008694	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634177008695	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
634177008696	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
634177008697	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
634177008698	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
634177008699	catalytic triad [active]
634177008700	conserved cis-peptide bond; other site
634177008701	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634177008702	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634177008703	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
634177008704	Putative lysophospholipase; Region: Hydrolase_4; cl19140
634177008705	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
634177008706	DDE superfamily endonuclease; Region: DDE_3; cl19249
634177008707	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177008708	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177008709	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634177008710	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177008711	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
634177008712	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634177008713	active site
634177008714	DNA binding site [nucleotide binding]
634177008715	Int/Topo IB signature motif; other site
634177008716	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
634177008717	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
634177008718	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
634177008719	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
634177008720	FMN binding site [chemical binding]; other site
634177008721	active site
634177008722	substrate binding site [chemical binding]; other site
634177008723	catalytic residue [active]
634177008724	Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_4; cl17873
634177008725	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
634177008726	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
634177008727	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
634177008728	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
634177008729	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
634177008730	acyl-activating enzyme (AAE) consensus motif; other site
634177008731	AMP binding site [chemical binding]; other site
634177008732	active site
634177008733	CoA binding site [chemical binding]; other site
634177008734	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
634177008735	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
634177008736	MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042
634177008737	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
634177008738	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
634177008739	AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049
634177008740	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
634177008741	dimerization interface [polypeptide binding]; other site
634177008742	putative ATP binding site [chemical binding]; other site
634177008743	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634177008744	Coenzyme A binding pocket [chemical binding]; other site
634177008745	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
634177008746	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634177008747	FeS/SAM binding site; other site
634177008748	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
634177008749	putative active site [active]
634177008750	catalytic triad [active]
634177008751	putative dimer interface [polypeptide binding]; other site
634177008752	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
634177008753	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
634177008754	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
634177008755	DNA-binding site [nucleotide binding]; DNA binding site
634177008756	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634177008757	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634177008758	homodimer interface [polypeptide binding]; other site
634177008759	catalytic residue [active]
634177008760	Transposase domain (DUF772); Region: DUF772; pfam05598
634177008761	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177008762	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177008763	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
634177008764	Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544
634177008765	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634177008766	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
634177008767	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
634177008768	Transposase domain (DUF772); Region: DUF772; pfam05598
634177008769	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177008770	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177008771	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
634177008772	potential frameshift: common BLAST hit: gi|162146821|ref|YP_001601282.1| glutathione S-transferase
634177008773	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
634177008774	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
634177008775	N-terminal domain interface [polypeptide binding]; other site
634177008776	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
634177008777	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
634177008778	putative C-terminal domain interface [polypeptide binding]; other site
634177008779	putative GSH binding site (G-site) [chemical binding]; other site
634177008780	putative dimer interface [polypeptide binding]; other site
634177008781	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634177008782	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634177008783	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
634177008784	AAA domain; Region: AAA_33; pfam13671
634177008785	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
634177008786	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
634177008787	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
634177008788	Walker A motif; other site
634177008789	ATP binding site [chemical binding]; other site
634177008790	Walker B motif; other site
634177008791	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634177008792	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177008793	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177008794	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177008795	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177008796	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634177008797	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
634177008798	dimer interface [polypeptide binding]; other site
634177008799	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177008800	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177008801	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634177008802	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
634177008803	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177008804	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
634177008805	Cl- selectivity filter; other site
634177008806	Cl- binding residues [ion binding]; other site
634177008807	pore gating glutamate residue; other site
634177008808	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
634177008809	dimer interface [polypeptide binding]; other site
634177008810	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634177008811	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177008812	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177008813	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177008814	Protein of unknown function, DUF488; Region: DUF488; cl01246
634177008815	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
634177008816	PAS domain; Region: PAS_9; pfam13426
634177008817	putative active site [active]
634177008818	heme pocket [chemical binding]; other site
634177008819	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
634177008820	Protein of unknown function, DUF488; Region: DUF488; pfam04343
634177008821	Transposase domain (DUF772); Region: DUF772; pfam05598
634177008822	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177008823	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177008824	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634177008825	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634177008826	myosin-cross-reactive antigen; Provisional; Region: PRK13977
634177008827	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; pfam06100
634177008828	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634177008829	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634177008830	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
634177008831	putative effector binding pocket; other site
634177008832	dimerization interface [polypeptide binding]; other site
634177008833	Pirin; Region: Pirin; pfam02678
634177008834	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
634177008835	Transposase domain (DUF772); Region: DUF772; pfam05598
634177008836	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177008837	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177008838	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
634177008839	HNH endonuclease; Region: HNH_2; pfam13391
634177008840	Transposase domain (DUF772); Region: DUF772; pfam05598
634177008841	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
634177008842	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177008843	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
634177008844	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634177008845	NAD(P) binding site [chemical binding]; other site
634177008846	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
634177008847	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634177008848	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634177008849	Predicted transcriptional regulator [Transcription]; Region: COG2378
634177008850	HTH domain; Region: HTH_11; pfam08279
634177008851	WYL domain; Region: WYL; pfam13280
634177008852	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
634177008853	active site
634177008854	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634177008855	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634177008856	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634177008857	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634177008858	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
634177008859	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634177008860	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634177008861	MobA/MobL family; Region: MobA_MobL; pfam03389
634177008862	Preprotein translocase subunit Sec66; Region: Sec66; cl02341
634177008863	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
634177008864	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
634177008865	non-specific DNA interactions [nucleotide binding]; other site
634177008866	DNA binding site [nucleotide binding]
634177008867	sequence specific DNA binding site [nucleotide binding]; other site
634177008868	putative cAMP binding site [chemical binding]; other site
634177008869	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270
634177008870	Conjugal transfer protein TraD; Region: TraD; cl05753